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<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCQ3</accession>
    <name>A0A1D8PCQ3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C102430CA</name>
        <name evidence="11" type="ordered locus">orf19.10447</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721430.2">
        <property type="nucleotide sequence ID" value="XM_716337.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCQ3"/>
    <dbReference type="SMR" id="A0A1D8PCQ3"/>
    <dbReference type="FunCoup" id="A0A1D8PCQ3">
        <property type="interactions" value="1250"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCQ3"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PCQ3"/>
    <dbReference type="GeneID" id="3636846"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102430CA"/>
    <dbReference type="CGD" id="CAL0000199029">
        <property type="gene designation" value="orf19.10447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02430C_A"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCQ3"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="221"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000199029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW25927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="643" mass="71092" checksum="936A4F0A9D638736" modified="2017-01-18" version="1">MSKTTEIFCRLPKSVELIQDFKDITPSPKANAECRAALYSKNGDFFAYTQPQEVVILDTTGEAKVYHRIEIPEVFDIYFSPEGTYLCLWCKPIQLNKENGTWNNNLKIFNIKTKTIIAEWSAKHQNAWKPQFTSEENLFARSINQKEIHFFELDPTSDSTVNINQPSFKYKVNDPKATLQAFQISPGRNPSVAIFIPEKSGKPANVSIYNIPNFNQPICFKNFFKAEKCQLKWNSLGTALLALASTDHDTTNKSYYGETNLYLLGIAGSYDSRIDLKREGPIHDITWSPTAREFAVSYGYMPSETTFFDSRGNAIHSLPTAPRNTILYSPHAKFVLVAGFGNLQGTVDVYDRQNKFSKVVTFEASNTSVCEWSPCGRFILTATTSPRLRVDNGCKIWHASGKLIYLKEFPELFSIGWKPQPLDCFPPIRNLEPAPEAHESTKEYLEKRQALASAAAKKPAGAYRPPHARGGGAGSGSGVASSLYQKELQNNLRSNGSTPSPPPGLSRAAGNIPRVRTVVGAPPPVEKESKAAAKNRKKREAKKQAQEKNNSPAPEATTSASPVPAQAQAPASTPAPTPATAGVIGGVASLEEKKIRSLLKKLRAIEQLKMKQASGETLEDTQVIKISKEDEIRSELQTLGWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PD21</accession>
    <name>A0A1D8PD21_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SIP3</name>
        <name evidence="10" type="ordered locus">CAALFM_C103450CA</name>
        <name evidence="9" type="ordered locus">orf19.10565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721545.2">
        <property type="nucleotide sequence ID" value="XM_716452.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PD21"/>
    <dbReference type="SMR" id="A0A1D8PD21"/>
    <dbReference type="FunCoup" id="A0A1D8PD21">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PD21"/>
    <dbReference type="GeneID" id="3636910"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103450CA"/>
    <dbReference type="CGD" id="CAL0000193067">
        <property type="gene designation" value="SIP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03450C_A"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PD21"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000186">
        <property type="entry name" value="Transcription modulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR004148">
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    <dbReference type="InterPro" id="IPR011993">
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    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
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    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
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    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="327"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="783"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000193067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1209" mass="138532" checksum="81D9D787841D6401" modified="2017-01-18" version="1">MPSTSSVESGPDPNILSSMVKSPKSDKSKPLSSQPHQETLLHHFKLISVNFKEAALDSPSFRASMNHLDLQINTIEQWLTALASSFKKIPKYLKEVQSYSNSFLEHLVPTFIQDGIIDQEYTVTGLNTTLDGLKTVWGLSIQALSVDAKNLKSIELFKRHHVIKYKETRKRYEDYQAKYDKYLSIYLSSSKSKDPLMVIEDAKQLYQVRKEYIHASLDLVIEIQNLSKNLNKLLVGVNTDLWRNKWNIFGSRGVGDAIKEEWDKIQRIQSWNDSYTLAIEKLNSDMLAARNQVEEGCHIQFQPSTNVNDYKSTIINNRTLRDIDEPGVEKHGYLFMKTWTEKSSKPIWVHRWAFIKNGVFGLLVVSPSQTFVQETDKIGILLCNVRYAPNEDRRFCFEIRTNDFTAVFQAESLVELKSWLKVFENEKFRISGPEALSNGLFNIASGRFPPIISEFSSTVDTVIDQQLTNAKVTLAGGQIVAASSLSNHLERFEDFFKKYMYFEIPKICPPFMTDTTKSSIMAYCLTSPTQIPNALTANIWGSVNWGLYYLHDTARDSSTYLTGKDAEMIKFQEEHFENDKFYPDFYPKEYVNLDIQMRALFETAVEPGEYCVLSYSCIWSPNSKQELSGRCFVTNYHMYFYMQALGFVALFKGFLGHLVSVEFVSQKNYDLMKVYNIDGVIKMKVFLDDAICIKKKLVYLINNIVSDKPKSLEGVLADFSDIEKEIAVEKSDQKNLREISQLSKGLSSKSLASEKLLLSGETSSILPGKSGRMIKHRVNFTPDYNLISDRTYPAPPKAIFHALLGDNSVVFRSQLSFASTKYFLQKPWATSSKGTLYRDFNVPAMYDGKDCFVQVRQEIDNMEDNTYYTFTHEMSKFELLLGSPYKTVFKIVIVEHISKRSKVFVYSKTYFDRLSVWNPLVIRLNNQVDVNKVRKLEKSISEAVKEIGTHGMIVRAIYLYGKLSHTSKPEAVTSTSVIKFGIVSLFKLGLGKAFSKAYSFAVKSFIKPFQLVVLLLKSLRMNVFLVFIIVLLSFLNLFLAGKTATSYWNTRSASKLAQEYVTKEPRMLQRSVYLKDLESILNENISIAESRPFSLFKQNSFIFNLDADSDWSNYFGSNARDVARSLKSSFQDIGIKRHELLVKLKILKSMEEEIIQAEWQNWLMSEAQKCDYVMDNVVGQIDEVDNYQEGVDNIIEYCHECKKILANLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PD80</accession>
    <name>A0A1D8PD80_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysophosphatidic acid acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C104110WA</name>
        <name evidence="8" type="ordered locus">orf19.8645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713648.2">
        <property type="nucleotide sequence ID" value="XM_708555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PD80"/>
    <dbReference type="FunCoup" id="A0A1D8PD80">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PD80"/>
    <dbReference type="GeneID" id="3644699"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104110WA"/>
    <dbReference type="CGD" id="CAL0000184512">
        <property type="gene designation" value="orf19.8645"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04110W_A"/>
    <dbReference type="eggNOG" id="ENOG502SABN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PD80"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000184512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="305" mass="34866" checksum="821A65EB8E1FE4F7" modified="2017-01-18" version="1">MEKFSSWRDKGTGISPFMPQKLPTFQKNNSLLSVASKSPIFLIKLPFFIITYLIYTITGFAFILKFILTILFGFNRIDFGVDGIKKSQIDKLTSYKPKKGDLIVTNYITPLDGYFLFLLSGTFSSSSSSSSSSQIVILIPNESGDLYQYSPLGLFNHSFTYSNSNSNSSSSGKLVEDVSKLQNKIVFLFLEGTLSNNKSILPFIKLNSKYSFDDFNIKSLVVKLIPNYFTLPIPHVSKLQYFFELLTNLSQKSVRYKMYKFDEFDIAKIRNSFELNSLTSMSQDLNIDSKNKFIDYYFDHSIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDE1</accession>
    <name>A0A1D8PDE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C104800CA</name>
        <name evidence="13" type="ordered locus">orf19.8382</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713572.2">
        <property type="nucleotide sequence ID" value="XM_708479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDE1"/>
    <dbReference type="SMR" id="A0A1D8PDE1"/>
    <dbReference type="STRING" id="237561.A0A1D8PDE1"/>
    <dbReference type="DNASU" id="3644789"/>
    <dbReference type="GeneID" id="3644789"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104800CA"/>
    <dbReference type="CGD" id="CAL0000194369">
        <property type="gene designation" value="orf19.8382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04800C_A"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDE1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000164">
        <property type="entry name" value="Acid sphingomyelin phosphodiesterase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111024" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="328"/>
            <end position="537"/>
        </location>
    </feature>
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                <person name="Martchenko M."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_713748.2"/>
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        <property type="resolution" value="2.32 A"/>
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        <property type="interactions" value="866"/>
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    <dbReference type="STRING" id="237561.A0A1D8PDU3"/>
    <dbReference type="EnsemblFungi" id="C1_06580W_A-T">
        <property type="protein sequence ID" value="C1_06580W_A-T-p1"/>
        <property type="gene ID" value="C1_06580W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639515"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106580WA"/>
    <dbReference type="CGD" id="CAL0000197722">
        <property type="gene designation" value="RPS23A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06580W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PDU3"/>
    <dbReference type="OMA" id="KFRWSQR"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:translation"/>
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        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
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        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
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    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
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        <property type="entry name" value="RIBOSOMAL_S12"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456560" description="Small ribosomal subunit protein uS12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
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    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="145" mass="15966" checksum="EADDAF0A9E657E06" modified="2017-01-18" version="1">MGKGKPRGLNSARKLRVHRRNNRWADQAYKARLLGTAFKSSPFGGSSHAKGIVLEKIGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRRGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE64</accession>
    <name>A0A1D8PE64_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C107640CA</name>
        <name evidence="7" type="ordered locus">orf19.10297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711723.2">
        <property type="nucleotide sequence ID" value="XM_706631.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE64"/>
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        <property type="gene designation" value="orf19.10297"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_07640C_A"/>
    <dbReference type="eggNOG" id="KOG0032">
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="67"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="679"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000195277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="838" mass="94663" checksum="1B3561F3CE9287E7" modified="2017-01-18" version="1">MSISSTASTSTTTFYPTSNRTSIDTTATSINNDYVNTNKPTRLSTTSSLFTIDSELNDLYPELPSNFKLIELLGEGAFSSVYKAIDISKNNMIVAIKIINKINLNSKQLQNIINEINILKQINYHHHPNIIELLGVIDGINQTFLILEYCDGGEIFDQILKYTYLSEPLSYHVFKQILNALQYLHNTLNIVHRDLKPENLLFNKIPFFKRGINDNNLEKYLRKSDDINEKIDEGEFKYGIGGGTIGVIKLADFGLAKQLNDKNIAQTPCGTTGYTAPEVFQCRNNNNNNNNNNNNNNSNNSNKSSGGSGSGSGSIYHQLFKSSKSKVKTKSKQLSITNYSKSVDIWSLGCVLYTLLCGFPPFYNDDIEILTNNVINGKFEFLKPWWDEISNDAKDLVSKMLIIDPNERITIDEIWNHPWILKHMNNESKQRQQKQEEEEEEVPGYFPNHNKNTNIIKQTIFENVHEDIINPINKEKEEEDDDYSLSLAPPPPSQQIFSKSPRAIAIKKVFDNPAMTTNKSIKNKASICHGDNNDDDIYFANQEEEKEPLSFFIEDIAELDEEDEEIESEVTNDSDDSDSDSDEDVNVNVNEINEHLKIMGDLPFKTRKNHHDYIKTPYPKLISFKDVFNLNKINSPQEDNEEEEEEEEDLKNQFHRFKLSSQNLNSLNKSNGIDNLHKNSINDNDSDDTTSTTTTNSSILSNTPTYTTTNNNNNNNNSIDNYGRSPLRTNNNDNQLIDNHDEHDDTTTTNIPNHETRSSSIISGLNGDFKFTLNLTNSNLLTRRKNSNNIISPITSSSSSTTSSSIIINPIKSIKPTTSNIGDATTTIINTNATATII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEF5</accession>
    <name>A0A1D8PEF5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C108630WA</name>
        <name evidence="3" type="ordered locus">orf19.12184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723408.2">
        <property type="nucleotide sequence ID" value="XM_718315.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEF5"/>
    <dbReference type="SMR" id="A0A1D8PEF5"/>
    <dbReference type="STRING" id="237561.A0A1D8PEF5"/>
    <dbReference type="GeneID" id="3634928"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108630WA"/>
    <dbReference type="CGD" id="CAL0000189535">
        <property type="gene designation" value="orf19.12184"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08630W_A"/>
    <dbReference type="eggNOG" id="ENOG502RXV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEF5"/>
    <dbReference type="OMA" id="NRRISHH"/>
    <dbReference type="OrthoDB" id="4084661at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="196"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000189535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="445" mass="51809" checksum="38C67842BE2EEAA2" modified="2017-01-18" version="1">MRSPNGFLSSQWTRLLVSNRRISHHYTCIRWNHSSSDSQQTRQQVPISPEISGEIDAIGKKSTEKSFEGLSYDLSQLLDEDTLVGKQKDQNQSSEQLPIGSMMESSSDSEPMDFQQLSNFIKEAYEKNPNYKEMERSPSAKRRQVDYFEALFSKYGGTSDRGKKTKTKSSVSDSESDRISSLKEKLRGELTSRCTVALEPTLTHFRTYKTSHELFQTAQTILNNFAKKLQNVGKKTRKTNTSETDSVKLTQIREEIFVQHLFSPIDKNSWLDVHEEYVNNVETQSRLSPENPICDVITLPIIFNEIIDCLAFKFNQGQLAMSLFDLIEKDFSFHTIAVNQDTYNLILRLVWVYYGNTNLDQFYRRYHRMTSLGFTGDVKTLNILKTVYNEYDRLKNGKSIFNNSNSPIYTPEDNIRMEYFEKEYNKLKRRLEHGVQHKDFMLNNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEJ0</accession>
    <name>MNN47_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannosyltransferase regulator 47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MNN47</name>
        <name type="ordered locus">CAALFM_C109130WA</name>
        <name type="ordered locus">orf19.12234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2017" name="Front. Microbiol." volume="8" first="2156" last="2156">
            <title>Phosphomannosylation and the Functional Analysis of the Extended Candida albicans MNN4-Like Gene Family.</title>
            <authorList>
                <person name="Gonzalez-Hernandez R.J."/>
                <person name="Jin K."/>
                <person name="Hernandez-Chavez M.J."/>
                <person name="Diaz-Jimenez D.F."/>
                <person name="Trujillo-Esquivel E."/>
                <person name="Clavijo-Giraldo D.M."/>
                <person name="Tamez-Castrellon A.K."/>
                <person name="Franco B."/>
                <person name="Gow N.A.R."/>
                <person name="Mora-Montes H.M."/>
            </authorList>
            <dbReference type="PubMed" id="29163439"/>
            <dbReference type="DOI" id="10.3389/fmicb.2017.02156"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Golgi apparatus protein involved in phosphomannosylation, a modification of cell wall proteins that occurs in some species of yeast-like organisms and confers a negative charge to the wall, which is important for the interactions with phagocytic cells of the immune systems and cationic antimicrobial peptides (PubMed:29163439). While MNN47 seems to have a regulatory role in N-glycan mannosylphosphorylation, a transferase activity of MNN47 cannot be ruled out.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is induced during biofilm formation.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Slightly reduces the ability to bind the charged cationic dye Alcian Blue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MNN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723457.2">
        <property type="nucleotide sequence ID" value="XM_718364.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEJ0"/>
    <dbReference type="STRING" id="237561.A0A1D8PEJ0"/>
    <dbReference type="EnsemblFungi" id="C1_09130W_A-T">
        <property type="protein sequence ID" value="C1_09130W_A-T-p1"/>
        <property type="gene ID" value="C1_09130W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634943"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109130WA"/>
    <dbReference type="CGD" id="CAL0000176316">
        <property type="gene designation" value="MNN47"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09130W_A"/>
    <dbReference type="eggNOG" id="ENOG502SD1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEJ0"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000463377" description="Mannosyltransferase regulator 47">
        <location>
            <begin position="1"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
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        </location>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="29163439"/>
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        <source>
            <dbReference type="PubMed" id="29163439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26547.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Ketopantoate reductase C-terminal domain-containing protein</fullName>
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        <name evidence="4" type="ordered locus">CAALFM_C111770CA</name>
        <name evidence="3" type="ordered locus">orf19.8732</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="entry name" value="KPR-Related"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFD4"/>
    <dbReference type="FunCoup" id="A0A1D8PFD4">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFD4"/>
    <dbReference type="GeneID" id="30515061"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112320CA"/>
    <dbReference type="CGD" id="CAL0000179071">
        <property type="gene designation" value="ATP19"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12320C_A"/>
    <dbReference type="eggNOG" id="ENOG502S99W">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFD4"/>
    <dbReference type="OMA" id="FQPHQLA"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
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    <dbReference type="Proteomes" id="UP000000559">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
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                <person name="Dungan J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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</entry>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
    </reference>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000183039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="71" mass="7648" checksum="0B99727A3DB8B5CE" modified="2017-01-18" version="1">MLYALATPGSAFKPSIKKAKNTWRLQKFKKLYIQKGGYISSSPTDSSINSNDSISSSSSVITASSSAPRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG20</accession>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="3638828"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200340CA"/>
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        <property type="gene designation" value="ARO8"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C2_00340C_A"/>
    <dbReference type="eggNOG" id="KOG0634">
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    <dbReference type="InParanoid" id="A0A1D8PG20"/>
    <dbReference type="OMA" id="FMPGEPF"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
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        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
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        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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            <end position="438"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000187633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW27088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="491" mass="54744" checksum="143B9786B1B3F3C2" modified="2017-01-18" version="1">MTSDTKPQAKDLTHLLSNESKARQTSPLKGIFKYYKQPGITFLGGGLPLSDYFPFEKVTADIPTPSFSGGIGAPIEGENKTTIEVFKKAADNVPDQIELARSLQYGSTFGSPEFLQFIKEHTDMVHKVPYENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEEYTFSSALESANGQGVNTVPVTMDEFGIIPEKLEELMSRWVGNKPKFLYTICTGQNPTGSSLSAERRKQIYDIACKYDFLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVVRLDSFSKVLAPGLRLGWIVGQKDLLERYVRLHEVSVQNPSGLSEALANALLRKWGHSGYLDWLIGLRAEYTHKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDASKHPKYKEFLEDPLKVEAAVHEQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQLVVGLEKFGKAVRAEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHC5</accession>
    <name>A0A1D8PHC5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C205220CA</name>
        <name evidence="10" type="ordered locus">orf19.11035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714911.2">
        <property type="nucleotide sequence ID" value="XM_709818.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHC5"/>
    <dbReference type="SMR" id="A0A1D8PHC5"/>
    <dbReference type="FunCoup" id="A0A1D8PHC5">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHC5"/>
    <dbReference type="GeneID" id="3643466"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205220CA"/>
    <dbReference type="CGD" id="CAL0000181901">
        <property type="gene designation" value="orf19.11035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05220C_A"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHC5"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="8">
        <location>
            <begin position="689"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000181901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1032" mass="117912" checksum="61A6210904EF1C9A" modified="2017-01-18" version="1">MSIFKPRTIVKQSSTLPTATIHELTKNQHYCVSKLPALPSVFKSQADSFTNAYSDSESNYSLVINEDSIFVWCYKSTDATPLSIEFPIDKSIFQLPMAILTRPSSGTGQDPGLVILDSVSGLIKFYESVQHAPTLGLINDKSLEIDIPLKKDEYITLAENVEPAGIVIATSLQRCILISLRDFKSKPQLGYMELLNNEGFLQRFFKPETNEIVAIRSGKITNHGTIQEILVLDSSGNFYLYNYNLFSATASPYVDKKKSFRQCIRVEFDAYPGSNQFATFLDIWPVDDIYLALCQIEQSLYLVTLRIDKSGALPFGSHKLKTANFPSSKPKLYLPKPGKTAFVIIDNSVILTDLNTSYIESKNTLTYYKPRWEDVVRFKSSVEFVGSGFENQSPNSNPAVILISKNFGVVRIEKFPESQTDTAIEPLAIVRSHIEQAIFYSDVHEIDFDLSQRFGKDVIQRAIETIIEEILTSTSSYFPKTLPSISDLTNLKVKLYRKLIEYVKRNFDISIIPQIVENLEKTDVAHQMWTIVDANQEMKTVLETQLGDIREFFTHNVADINPVLTKFIENLVEKDLPTVPLVVKTLYNGVYLNEVEYVTQISKSWVFTTNLIIRAEEIFTRNFVESEGDPIVAYHLVQVLYYFVNSAIAYMRLTPENKAHLQDYQIWYNNRKQYWIGVLLKAGLEKEATEIAEKYHDFASLARILDIHQEETNSTDQSNYSKYFEEYGYSFASCVYDYYLEKNKIQELLLSFTNYKHFLLQYFKENPKKTANVSWIRYLLDTEFAEASNSLIVAAEENDSLDNQHIKYSLAKLSSVASGNGDNLKDINHELLIIKYQKIIKHSTADNGRIEAIKKPTFTKNFVNQEIDKQFIEPIVDIYFDRFVGGFELNNSEIINLLTTVKPSISNKSGFSYAFKIAESIYNKSIANYYSSMVLVRLLVLGDEKLYQVNDNDKTTKRKAKESALYKTLKQNPGAISKLDQLLNNPEINNAEYEDSITIKEFNESLLSQLTKQLGNAKFKSWVEAVKEQARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHH0</accession>
    <name>A0A1D8PHH0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EFM4</name>
        <name evidence="10" type="ordered locus">CAALFM_C205520WA</name>
        <name evidence="9" type="ordered locus">orf19.11066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330778.1">
        <property type="nucleotide sequence ID" value="XM_019475233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHH0"/>
    <dbReference type="SMR" id="A0A1D8PHH0"/>
    <dbReference type="FunCoup" id="A0A1D8PHH0">
        <property type="interactions" value="780"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHH0"/>
    <dbReference type="GeneID" id="3643421"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205520WA"/>
    <dbReference type="CGD" id="CAL0000200297">
        <property type="gene designation" value="orf19.11066"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05520W_A"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHH0"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000287">
        <property type="entry name" value="Protein-lysine N-methyltransferase EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="8">
        <location>
            <begin position="73"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000200297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="246" mass="28081" checksum="81E5B13B31FCB0F9" modified="2017-01-18" version="1">MTEEIRLNSSKLGSKEYWNNFYKKEQDNFNENEEDTGECWFDDSDAESKMIQFIIDKLNEEELPEEISSQSVVRFLDLGTGNGHLLFQLSEDINEEYEGDKTFEYTGIDYSPDSVKFASGVAKRKYSELKVNFEQVDLLQESCSFLQNKFDILLDKGTLDAIALNQESLADFNGKIGMDVYASQVEKMMVQGSILLITSCNFTKDELIKIITKDTNLEVWDEINYPSFQFGGVKGSTVVSIAFVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIB7</accession>
    <name>A0A1D8PIB7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C208620WA</name>
        <name evidence="3" type="ordered locus">orf19.11098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714459.2">
        <property type="nucleotide sequence ID" value="XM_709366.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIB7"/>
    <dbReference type="SMR" id="A0A1D8PIB7"/>
    <dbReference type="FunCoup" id="A0A1D8PIB7">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIB7"/>
    <dbReference type="GeneID" id="3643912"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208620WA"/>
    <dbReference type="CGD" id="CAL0000175986">
        <property type="gene designation" value="orf19.11098"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08620W_A"/>
    <dbReference type="eggNOG" id="KOG2427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIB7"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000175986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="493" mass="56402" checksum="AFC2DA37046EC2E1" modified="2017-01-18" version="1">MVEDSILLVDNSQPVESSYSTNPPVASGSTSSSRPTPTDTVQFPIKLINWSLDPQNQTIITTPILLQEINGPCPLIALCNTLLLNNDIRTNSFISDEGEGEGEDEDKGVDQLKFEALNNFKTNIINKYHSLGKIDLQQVLEYIGDLLLIHTENKTDWNRNHQNYNNSSQKEFTIDELLLKLPLLHTGLNVNPILISGDFEYDLATQLFELFELKFKHGWIIDPINQHGHHHQEEEGNSQDSQNSQNSQIWTNQEYGKLVNLFDQLENFDKIQDYLLLDQQQDKEVLGNKLLIEKWLNLNQTQLTLQGLNKLNDELDINQFIIFFRNNHFNTLFKKSNQEFYILLTDSSFVNSNKSSKIIWQSLNSVSGKDDLFFMGDFTPVLDIDQDLPNVNTSKLGGDIYSQDQNPDYLLLKQLQEEEDQKYAERLQNNYNNKSRQSKSKSKSSSTTKSSLSSNLNPSDPTTTTTTITEKLNSKEVINKDEKKKKKLNCTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
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        <name evidence="4" type="ordered locus">CAALFM_C208990CA</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707497.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PID2"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C208990CA"/>
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        <property type="gene designation" value="orf19.7836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08990C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PID2"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <end position="1048"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="5 6">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475268.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PIE8"/>
    <dbReference type="STRING" id="237561.A0A1D8PIE8"/>
    <dbReference type="GeneID" id="3647713"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209460CA"/>
    <dbReference type="CGD" id="CAL0000183461">
        <property type="gene designation" value="RHA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09460C_A"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIE8"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="PHI-base" id="PHI:12095"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:1900430">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000183461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="989" mass="113959" checksum="EC9EC0F06252F3CC" modified="2017-01-18" version="1">MKERKTRRSHTNSRDGCPNCKSKRIKCTEELPSCYNCIKKNYRCGYLDFPEHKLQIIRNKNNKRLLQEQRLLEMVTPGIPQQILQPLPPLPQQLQPPPPIAAAAVVQPPISSLIPPLQPPLQQQLQPPAPPFLSMPRPYHNITEQHSLQSNNDVFNHDNPTSYSHTPVPLHLNDQAQLIENNTGFSMPAATSGPQYHSNSASLYSSPLSTTPNCSNELIPNFQPPTIPNEENSITPPNIFEAVSNDKIDYSIEVPGSKSDLKIALYKDSVRKISLARNDLQLPSYSSDSPIYDKQTPKNEDYLVDSQQQQQNCVSHQSPSQHSKSNHNHQHQHHRDNNQNSLQYNNNTPIDRLSEFDTGYESQSSDGFGNTRHIFAEHFGIVITNDDHGIGRNNNIVHNRSMGDTISGNVGKPLPNARNSPISINLLNPTEHCGISLNQQHQAFENKMLVPTINWTSADNKSLWNSMFNGAVSSRYSFFSFFMDRSLNVILKACIKAINSGSNETCFNQHVQDILLKKSYIYYGTLIKDLRESMANDSIENSTILSWFANWSLFIHRSSTLKAENLILTGSASLLWNCLNQYQSTTQLNPTLSFIIHSIKWHTLACTTPDYKFNVIEELFDDFKHFKRFILFNQELTTKNNGYILKSFVDLENFLQQLIENIYPRMVKLDNDYKKKYEVPSEQMDRGIQFFSPEELFSIVVNWFNIVPGYALSVGKTMTPLKRTYYLFYAAIAVALAAVFPSIRGVFLVDPWNMIFARTDFDNSIYKISPSDLPKDEQYQYLSQLSKKLLRVINFFTTRRKLLLNYLGVKPHPFSHFKYMEKVEPLNDYDNVVRFKTEKMDFQEVMITSFNVNNIINVSNYPLMRMLYNNSDDNYQTFKRVIEKENHDQKVRITKFRANYERKEGKNIDTFNSYDRIRRTQSEGSQDSNELDDFDYDRGMFLYDYNIEHALTCVFDIFGREGKVFDDIGTIKQGLENFELAQKEIAKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIP2</accession>
    <name>A0A1D8PIP2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">KIP2</name>
        <name evidence="19" type="ordered locus">CAALFM_C210310CA</name>
        <name evidence="18" type="ordered locus">orf19.9315</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714393.2">
        <property type="nucleotide sequence ID" value="XM_709300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIP2"/>
    <dbReference type="SMR" id="A0A1D8PIP2"/>
    <dbReference type="FunCoup" id="A0A1D8PIP2">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIP2"/>
    <dbReference type="GeneID" id="3643954"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210310CA"/>
    <dbReference type="CGD" id="CAL0000197710">
        <property type="gene designation" value="KIP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10310C_A"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIP2"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903754">
        <property type="term" value="C:cortical microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01374">
        <property type="entry name" value="KISc_CENP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="76"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="424"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000197710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW28008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="665" mass="74859" checksum="3FB332FB03DD1554" modified="2017-01-18" version="1">MSHKTPTRARSCYANSSTTSMNSTPSRNSFRPPSRLSLIPRSSSPIQPPRSRPSSAMSISRPSTPSMKSQEPYTGAITVSIRPNPNTIDNKNWSIDEFNNSIINTTDGTRFVFDNVFPMDRQLSNIQVYNKSCYNVVNKFLEEGYNGTIFAYGMTGSGKTFSMKGCENDPGFVELAINDIFQKINDNTTTKKYKMDISYLEIYNEKIIDLLSGSASSPTTSQSNQDLKIRDDVDFGTKVVGLTSANISSKPQLLQLIKYGDTNRKTSATDFNARSSRSHSILQIRLQVIDLLTETELKSTLSLCDLAGSERAATSLERRKEGSFINKSLLALSNVINKLSSSTLEHIPYRDSKLTRLLQPALSGSSLVSILCTIHMGGNQQNSQQCVAETYKTLRFAARAKDIVINVEKNMSHKLDGGDSSKMIQELNEIISKQRQEIIKLQSNTGVSSEKFENSRIVQLESENRVLIEKLDHLTRLTDLQKTETAIIKNDILNDILASGLDNSQILMTNIEDFYKKMTYEANEYKSYICRLETQLRLESINSTQQQQSSSPTSSIPMTNTTNDSSELMDALKEQEEEILMLKEQLKDKDQIIKSLSQTTRLRRLVGNNNNSTANSHNTYNTLDNDFKRHTTIVNFDKENYEPELRDFKLSPKKPKSNCDILESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIS5</accession>
    <name>A0A1D8PIS5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">HEM4</name>
        <name evidence="3" type="ordered locus">CAALFM_C210340WA</name>
        <name evidence="2" type="ordered locus">orf19.9311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="20 21 22" key="4">
        <citation type="journal article" date="2018" name="Proc. Natl. Acad. Sci. U.S.A." volume="115" first="E9649" last="E9658">
            <title>Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.</title>
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                <person name="Chua S.M.H."/>
                <person name="Low Y.S."/>
                <person name="Lee Y.T."/>
                <person name="Agnew-Francis K."/>
                <person name="Wang J.G."/>
                <person name="Nouwens A."/>
                <person name="Lonhienne T."/>
                <person name="Williams C.M."/>
                <person name="Fraser J.A."/>
                <person name="Guddat L.W."/>
            </authorList>
            <dbReference type="PubMed" id="30249642"/>
            <dbReference type="DOI" id="10.1073/pnas.1809422115"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 47-683 IN COMPLEX WITH FAD; MG(2+) AND THIAMINE DIPHOSPHATE</scope>
    </reference>
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            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
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    <sequence length="683" mass="74334" checksum="8A833DE0DE43E13C" modified="2017-01-18" version="1">MISRNLRTSSTKTFYGSILRSQIRSISKNNSQQATAQSTSRPQPSPAFNTADTSTQPIINDPTLNKHQSSAISRKKKEQLMDDSFIGLTGGEIFHEMMLRHKVDTVFGYAGGAILPVFDAIYNSDKFKFVLPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMADALMDGVPLVVFSGQVPTTAIGTDAFQEADIVGISRSCTKWNVMVKNVAELPRRINEAFEIATTGRPGPVLVDLPKDVTASILRESIPINTTLPSNALSQITKKAVSEFTSEAIKRAANILNKAKKPIIYAGAGILNNEQGPKLLKELADKANIPVTTTLQGLGAFDQRDPKSLDMLGMHGSAAANTAIQNADCIIALGARFDDRVTGNISKFAPEAKLAASEGRGGILHFEISPKNINKVVEATEAIEGDVTANLQSFIPLVDSIENRPEWFNKINEWKKKYPYSYQLETPGSLIKPQTLIKEISDQAQTYNKEVIVTTGVGQHQMWAAQHFTWTQPRTMITSGGLGTMGYGLPAAIGAQVAKPDAIVIDIDGDASFNMTLTELSSAVQAGAPIKVCVLNNEEQGMVTQWQSLFYEHRYSHTHQSNPDFMKLAESMNVKGIRITNQQELKSGVKEFLDATEPVLLEVIVEKKVPVLPMVPAGKALDDFILWDAEVEKQQNDLRKERTGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKJ7</accession>
    <name>A0A1D8PKJ7_CANAL</name>
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        <name evidence="12" type="ordered locus">CAALFM_C306430WA</name>
        <name evidence="11" type="ordered locus">orf19.7428</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <name>Zn(2+)</name>
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        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
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        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
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        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="40"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000192941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="364" mass="40887" checksum="C8BDC0052D387F9D" modified="2017-01-18" version="1">MPPKIKSVKPFKYERSGLSKFKFGAHVGMSGGISNAVLNAMDIGANSFALFLKSPRKWVSPDIKEEEIKKFHELCEKYGYNSRTDILPHGSYFINLGNPDPEKEEKAYGSFLDDLKRCEKLNIGMYNFHPGSSLDGDHKESLARLAKNINKAIEETEFVKIVIENMAGHGNLIGSNLQDIKDVIDMVEEKSRVGVCLDTCHSFAAGYDISDKEKFEDFLKQFDEIIGAEYLSAIHLNDSKAPLGANRDLHQKLGYGFLGLEVFRVIANSDRLKNIPIILETPVGNDDSVYGEEIKLLEWLEGRPIDNPEFIAKKDELSKLGSKERAEHLKKFEAKNAKAEKKSAKRKNGEDIMSALTKKAKKKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLA4</accession>
    <name>ZCF27_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc cluster transcription factor ZCF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ZCF27</name>
        <name type="ordered locus">CAALFM_C401380WA</name>
        <name type="ordered locus">orf19.12118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Front. Microbiol." volume="6" first="367" last="367">
            <title>Examining the virulence of Candida albicans transcription factor mutants using Galleria mellonella and mouse infection models.</title>
            <authorList>
                <person name="Amorim-Vaz S."/>
                <person name="Delarze E."/>
                <person name="Ischer F."/>
                <person name="Sanglard D."/>
                <person name="Coste A.T."/>
            </authorList>
            <dbReference type="PubMed" id="25999923"/>
            <dbReference type="DOI" id="10.3389/fmicb.2015.00367"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor required for full virulence in mice.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Affects virulence towards mice.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722720.2">
        <property type="nucleotide sequence ID" value="XM_717627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLA4"/>
    <dbReference type="SMR" id="A0A1D8PLA4"/>
    <dbReference type="STRING" id="237561.A0A1D8PLA4"/>
    <dbReference type="EnsemblFungi" id="C4_01380W_A-T">
        <property type="protein sequence ID" value="C4_01380W_A-T-p1"/>
        <property type="gene ID" value="C4_01380W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635631"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401380WA"/>
    <dbReference type="CGD" id="CAL0000179708">
        <property type="gene designation" value="ZCF27"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01380W_A"/>
    <dbReference type="eggNOG" id="ENOG502QR47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLA4"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070786">
        <property type="term" value="P:positive regulation of growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463355" description="Zinc cluster transcription factor ZCF27">
        <location>
            <begin position="1"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2 3">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25999923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="25999923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1196" mass="137114" checksum="5F4FB54EB27C2508" modified="2017-01-18" version="1">MSTPVKNDSITATSSTSSSTPSQPPMQNNSPYPMQPIPQPPSSQQQQQQHLQQPIPPIPVQIMPQPVQPQQQQQQQQQQQQQVPPQYAGNYYQQRPAPGYYTPSSSLDFYQVGAQRGNSVSFQPTQGSPLQHQQHASGNTTHLPLPQPPQRPLSQQQVGIPQPAPAPQLQLQPRPQHQASPPPPVQQPVQQPVQQPVQQPVQQPGQEQWKENRKRNHSSMQQTTRVAATYPRKRALTACDTCRLKKIKCDNVRPRCGSCIKNGNLNCHYRTDDQQKDYSSYDPASLNILSKLDVILKDLKEIKSGNSNTGTISTNSTDKPSPDDPSSMSSTFSPAPTQQQQQQQQQHPQRLTKAQGKKFTFDKCIWDMSVLSIFKWDFFKNTFNLSSKDIEDIERQLKNDYDTDNSKNIGVIRHNSLIESIKQYEILEKLVSNNFLTIMNSFFVNAYTKVPILESYEFFDILETFQILLQHLPNMSFSRLVELYIDDNTIPPEVQQVFCIDDDDDNNNSQSNEKRKLTVEQYIRLIKSIPLILIISALGIISVPVQLDNLTKYKNSQEEAKSISVGCLSGDNVFNDIPADFPRQRNVIAFMLKDYAQLLCNVFSFILENNTIESVQYYLFLSQLHLQQNSIILAQRACLTASQNVMYLLEKTDLTKVSQLKLEVINRLYWTCLKLECELNVELSPFVPLSGITQVDPPSTFPKIPESPKNDELKSKFNYSDNAIRLSQYYNDRYSWYYFLTEIAVRKVDNEMFDEIYSLENNLNHLWDSQIFADKTIWSSFIEYLNRYNGIINSLTPEIRNFVLHEVNVEQIFHRLKKKYERKQLQENKTNNTATATAVNADEIIDNLDDFLIDEDLIVRAQSENIMFIKTRVVVSKLLLFRPLVYLFLQDKIPFIDIVQAVISVMGDSMNINPNPNTNTNTTSGISSSTFAIDNFNFMDSPNSSIGSATGSATGSKSRSSSTIFNLINDNESNGDLEMDYFNLINAPLFYQKQFPDEDFSKLIEYDYDYDNNEQQQQQQPTTTITIKNLSLVKQRILRIFISNLISIPKLNIPKLGTHRHPGSWYYIRNLFIGNVFQYLIYKKIQQMIYKATADVELQSILKSQLEQAQKENNDSSSSSSSSSQQPKSMEEIIGLINMVIDVKGIIASLEHSVILMEYWKLEIKDCQIYQDFIKKILNDLQNHQQQQQQFSTQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLS6</accession>
    <name>A0A1D8PLS6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C403310CA</name>
        <name evidence="1" type="ordered locus">orf19.1440.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330919.1">
        <property type="nucleotide sequence ID" value="XM_019475374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLS6"/>
    <dbReference type="SMR" id="A0A1D8PLS6"/>
    <dbReference type="GeneID" id="30515255"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403310CA"/>
    <dbReference type="CGD" id="CAL0000193990">
        <property type="gene designation" value="orf19.1440.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03310C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PLS6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000193990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="66" mass="7946" checksum="67D12B23969827E5" modified="2017-01-18" version="1">MNGLMPLRIMGYRKINKGVLLRFLFEGKIIKWLKLQDALEEYPDITDDYLDDYPDLQDYHLDHTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLY4</accession>
    <name>A0A1D8PLY4_CANAL</name>
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        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">PYC2</name>
        <name evidence="23" type="ordered locus">CAALFM_C403940CA</name>
        <name evidence="22" type="ordered locus">orf19.8408</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720913.2">
        <property type="nucleotide sequence ID" value="XM_715820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLY4"/>
    <dbReference type="SMR" id="A0A1D8PLY4"/>
    <dbReference type="FunCoup" id="A0A1D8PLY4">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLY4"/>
    <dbReference type="GeneID" id="3637323"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403940CA"/>
    <dbReference type="CGD" id="CAL0000188525">
        <property type="gene designation" value="PYC2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03940C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PLY4"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="26"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="148"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="21">
        <location>
            <begin position="566"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="1102"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="773"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="907"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0000188525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1177" mass="129699" checksum="09E5C29A6828AE7A" modified="2017-01-18" version="1">MTSIQKATSQDARINQMRRESTVLGPMNKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSMHRLKADESYVIGKKGQFSPVGAYLQIDEIIQIALKHNVNMIHPGYGFLSENSEFARKVEENGLIWIGPSYKTIDSVGDKVSARTLAIENDVPVVPGTPGPIESVDEAKKFVEKYGLPVIIKAAFGGGGRGMRVVREGDDIEDAFKRATSEAKTAFGNGTCFIERFLDKPKHIEVQLLADNYGNVIHLFERDCSVQRRHQKVVEIAPAKNLPKSVRDAILTDAVKLAKSANYRNAGTAEFLVDEQNRHYFIEINPRIQVEHTITEEITGVDIVAAQIQIAAGASLQQLGLLQDKITTRGFAIQCRITTEDPTKNFQPDTGKIEVYRSAGGNGVRLDGGNGFVGSIISPHYDSMLVKCSCSGSTYEIARRKMLRALIEFRIRGVKTNIPFLLALLTNEVFITGDCWTTFIDDTPSLFQMISSQNRATKMLSYLADLVVNGSSIKGQVGYPKLDTDAIIPEIHEPKTGITIDVDHTPPPRGWRQVLLEEGPEVFAKKVRQFNGTLITDTTWRDAHQSLLATRVRTIDLLNIAPTTAHALKGAFSLECWGGATFDVCMRFLYEDPWARLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDQFVKEAKENGVDIFRVFDALNDLEQLKVGIDAVKKAGGVVEATVCYSGDMMKPGKKYNLQYYLKVVDEIVKMGTHFLGIKDMAGTLKPAAARLLVGEIRSRYPDLPIHVHTHDSAGTGVASMTACAIAGADVVDAASNSMSGLTSQPSISAILASLEGSIETGLSESMVRELDNYWAQMRLLYSCFDADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGTKWVQTKETYKVANQILGDLVKVTPTSKVVGDLAQFMVSNTLTEEDVNRLASELDFPDSVLDFFQGLMGTPYGGFPEPLRTNILGNKRQKLNQRPGLTLPPIDFIAIKEELTSRYGTQITETDIASYVMYPKVFEQFRKIVDKYGDLSVLPTRYFLKPCNIGEELTVDIEQGKTLIIKLMAVGDVSEKTGTREVFFELNGEMRSVSVEDKTVSVESKTRPKASASNEVGAPMAGVVIEIRAHKHQQIAKGDPIAVLSAMKMEMVISAPCSGEIGDILIHEGDSVDANDLITSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM30</accession>
    <name>A0A1D8PM30_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C404380CA</name>
        <name evidence="3" type="ordered locus">orf19.1409.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330925.1">
        <property type="nucleotide sequence ID" value="XM_019475380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM30"/>
    <dbReference type="SMR" id="A0A1D8PM30"/>
    <dbReference type="GeneID" id="30515266"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404380CA"/>
    <dbReference type="CGD" id="CAL0000193435">
        <property type="gene designation" value="orf19.1409.2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04380C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PM30"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000193435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="94" mass="10723" checksum="2F910884E281E64C" modified="2017-01-18" version="1">MFVNNTRYLLQSSSTASPSAIPSKDSSHGIFSISQEYTGLVIFFALCCLFVLLAIFYFQENSNNPLMLSTTYQELKQEYNSNHNNDNESNDNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMD0</accession>
    <name>A0A1D8PMD0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C405640CA</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716557.2">
        <property type="nucleotide sequence ID" value="XM_711464.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMD0"/>
    <dbReference type="SMR" id="A0A1D8PMD0"/>
    <dbReference type="FunCoup" id="A0A1D8PMD0">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMD0"/>
    <dbReference type="GeneID" id="3641813"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405640CA"/>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05640C_A"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMD0"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="279" mass="30824" checksum="D796F68A246C3959" modified="2017-01-18" version="1">MTKFRGCIDIHSGQVKQIVGGTLTQDDSASSETSSTKENFVSTKPSSHYAQLYKDYNVKGCHVIKLGSNPANDDAAKLALSTWPHNLQVGGGINLDNAQYWLDQGASHVILTSWLFTKNEQDKMELDFGKLREINKLIGKEKLIVDLSCRTVIENGKTNWYVAMNKWQTITDTILSAEFLLKVSAYCDEFLIHAADVEGLCKGIDEKLVENLGEWCPVGFEEKIVYAGGAKSINDLDTVAKLSKGKVDLTYGSSLDIFGGKLVNFTDLVEWNKANSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMS3</accession>
    <name>A0A1D8PMS3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C407210WA</name>
        <name evidence="3" type="ordered locus">orf19.10596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715394.2">
        <property type="nucleotide sequence ID" value="XM_710301.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMS3"/>
    <dbReference type="SMR" id="A0A1D8PMS3"/>
    <dbReference type="STRING" id="237561.A0A1D8PMS3"/>
    <dbReference type="GeneID" id="3642959"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407210WA"/>
    <dbReference type="CGD" id="CAL0000178242">
        <property type="gene designation" value="orf19.10596"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07210W_A"/>
    <dbReference type="eggNOG" id="ENOG502RYH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMS3"/>
    <dbReference type="OMA" id="LQKHENW"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="75"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="293" mass="35028" checksum="BF696C233BB98297" modified="2017-01-18" version="1">MESRKLRSKSSKVESKALFDFDNVNEYLYSDKEIAIGGNGAVYHYYGCGMPELPKLKSNTKIVERQLPRRPPKEDPLPDTTYDIFYRRMKKNEKQMSNEERIKNLWELDTLQSQLERLTQYDWIRSLPDITVIKDMKDYDELERKKELTIKEIERLLQKHENWRKRKEVHSQEMKEWYGGSDSEYDVPIEELRERRKLEKRQRYGPVIRLNLGNDYCLVIDPLATPKIEKCEEPPKPKGKPITKLEDVEDISQIDIQTKDNILFGTNFEDIPTYRNGFQLPLHMRRMMHKQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN61</accession>
    <name>A0A1D8PN61_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carbon catabolite-derepressing protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">SNF1</name>
        <name evidence="19" type="ordered locus">CAALFM_C501320WA</name>
        <name evidence="18" type="ordered locus">orf19.9491</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715699.1">
        <property type="nucleotide sequence ID" value="XM_710606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN61"/>
    <dbReference type="SMR" id="A0A1D8PN61"/>
    <dbReference type="FunCoup" id="A0A1D8PN61">
        <property type="interactions" value="1080"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PN61"/>
    <dbReference type="GeneID" id="3642643"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501320WA"/>
    <dbReference type="CGD" id="CAL0000201729">
        <property type="gene designation" value="SNF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01320W_A"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN61"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061762">
        <property type="term" value="P:CAMKK-AMPK signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:fungal-type cell wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:invasive growth in response to glucose limitation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of inositol phosphate biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of TORC1 signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000222">
        <property type="term" value="P:positive regulation of pseudohyphal growth"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:response to unfolded protein"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090606">
        <property type="term" value="P:single-species surface biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
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        <property type="entry name" value="KA1/Ssp2_C"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
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    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="53"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000201729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="618" mass="69763" checksum="17C20B65B433E948" modified="2017-01-18" version="1">MSEQAQTQVSADQQQHQHNHHHHHHHHHHNENQSQQQVPIDPAANPANRIGRYQILKTLGEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPENLLLDDQLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSAGVILYVMLCGRLPFDDEFIPALFKKISNGVYTLPNYLSAGAKHLLTRMLVVNPLNRITIHEIMEDEWFKQDMPDYLLPPDLSKNKNSKIDVDEDVIRALSVTMGYDRDEIVNVIEKANKQVAAGNSSSQQSKSSNEILDAYLLMKENHALVKDLKKSKSENIESFLSQSPPPSPFPNAGSTSSAPGVQQSLTYQTLATVPDLSTLPNSTIAILPTSLPSIHRAYMAETKQNGDPSQQHAPPPTKKSKTRWHFGIRSRSYPLDVMGEIYRALKNLGAEWAKPTEEELWTIRVRWKYDTSAQFECGSAPNLMKMQIQLFQLEPNNYLVDFKFDGWESAHGNAGTDSPQSHRQQDLDEVGSFSAYPFLHLATRLIMELAVNSQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNF0</accession>
    <name>A0A1D8PNF0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C502310CA</name>
        <name evidence="1" type="ordered locus">orf19.11714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330963.1">
        <property type="nucleotide sequence ID" value="XM_019475418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNF0"/>
    <dbReference type="GeneID" id="3637787"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502310CA"/>
    <dbReference type="CGD" id="CAL0000192342">
        <property type="gene designation" value="orf19.11714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02310C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PNF0"/>
    <dbReference type="OrthoDB" id="4019681at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000192342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="643" mass="73955" checksum="B34D5377B6F4C835" modified="2017-01-18" version="1">MIETLKINRSTSIALHDLIQIKPVRVSLSGPIPYELNAVKYTVKCENPISKSNTGFKNTIRRTHWYPDITINSTYNIKDLQLEFIESYLPPPFQSLQSEMKKWRHLDFKVDIPMIVHPSHKRLLIHAPPKWSLPDSIDLFDVSRDNLSSHIPKHSIPEREVLLIEDKSASSKYFCQHQFLFTPPQPCINRMRYHTWAYNDSSLATPCTEDITQYLLDQNRVTESGKYLVLPVACPNIKMKNSPATTISQFIFSHLKLEKHNWKLPSHVLIENMSWNPFKVDVANFVDKYLMETITRKKSFMTTIDKTIISSVQMVLLPKTTATFPKISKIESSHELKPVNIRDSKRNNTPTKSDGLTNTQIQTNIATYHNDTDIMNELISSRKRKRKKLGTVSNVVLPPEISTLSFVEPKTPPQHNETTEETQNCAELSISTNKSAFAATQHIIINETLWDTNNQLAKSLSDVVHIFEMKIKLPIDIIVNVTTGIYCTSSDYLLQSDGHCEFLILKTLLLLKKHFHSLFVFATVSTPIFLKHSTEKIQKLQVLCMSLNIKLFLIPPHDLIVWILQVLRVEGPEKSSRFIDTDNPDGNFLSECGLSYFQVNQVLQRCSFNEFLVMDTKEKINQFREIVTSELIYQLESILSQEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNF7</accession>
    <name>ZCF22_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc cluster transcription factor ZCF22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ZCF22</name>
        <name type="ordered locus">CAALFM_C502430WA</name>
        <name type="ordered locus">orf19.11726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probably acts as a transcritpion regulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720560.2">
        <property type="nucleotide sequence ID" value="XM_715467.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNF7"/>
    <dbReference type="SMR" id="A0A1D8PNF7"/>
    <dbReference type="STRING" id="237561.A0A1D8PNF7"/>
    <dbReference type="EnsemblFungi" id="C5_02430W_A-T">
        <property type="protein sequence ID" value="C5_02430W_A-T-p1"/>
        <property type="gene ID" value="C5_02430W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637727"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502430WA"/>
    <dbReference type="CGD" id="CAL0000188293">
        <property type="gene designation" value="ZCF22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02430W_A"/>
    <dbReference type="eggNOG" id="ENOG502S484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNF7"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463351" description="Zinc cluster transcription factor ZCF22">
        <location>
            <begin position="1"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000188293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="699" mass="79216" checksum="BAADEC2F85A56C0C" modified="2017-01-18" version="1">MNSEISTNNDDIDPLLSLDQQQQQIRNPNPKRRKHNRVRTGCFTCRKRKKKCDEHQPNCENCIRNKLKCQYPSQWNEALPLNFKLETFQYDELVPLHYKRKKISTNLKSQKVPQDLFGVFLLNTSSLDVSNSNRKNNGIPAIGETVDTENVEEEVIDTKLGNSTSYESVEIITQSPIKSSSSTPSTSLSLLTHNDNQAAEHKTIEVDHPDNALSWVFAGPVTNLHLFGKYIPNIELSPQDAELYVHCARDFMQQVSLPHAHPSLSPPNVWVNLVLESSILIDVYLSCGATYLACLHQNSKVDPLHEQSSQQLQINDNAQLSQKYRELSEIKYNLAVKSLMSAISTNSIDLDSDWLMTAGLSLCLRDRANGLNGSRCTKHVSFVYNLIKRRIDKKRQSQSLGNASPLLSSITPVERLLIDSFLFNYTCSLLTCGKQDYASLPSPYSFFPDIENWFDAPIVQNCEVKWMNNPVLGAARNSFQTLAKLIYLLRSHYEFDGDADDNSHYTNDETFWELILALNDQEIDQVEKDNVLKLNQLLKIFPLGSKTMVTSHTGEQLSYSVLRSNLAVSIITIHACKILAAKLINPKIPAYLPEIQHSVSIILEELSLYIPQDNYSSSICIASLFFCGVAIINKPQQDLLCYKLSNLKNNLSQIVANNLISILKKCWDRETTERAIFGDKCYKCFDTIFDREILESVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNP8</accession>
    <name>A0A1D8PNP8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C503560WA</name>
        <name evidence="3" type="ordered locus">orf19.6667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711419.1">
        <property type="nucleotide sequence ID" value="XM_706327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNP8"/>
    <dbReference type="SMR" id="A0A1D8PNP8"/>
    <dbReference type="FunCoup" id="A0A1D8PNP8">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNP8"/>
    <dbReference type="GeneID" id="3646975"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503560WA"/>
    <dbReference type="CGD" id="CAL0000179768">
        <property type="gene designation" value="orf19.6667"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03560W_A"/>
    <dbReference type="eggNOG" id="ENOG502RZ9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNP8"/>
    <dbReference type="OMA" id="THITNNH"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000219">
        <property type="term" value="P:positive regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000179768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="168" mass="19200" checksum="88033A8BD107221B" modified="2017-01-18" version="1">MAIRNSHKESASESESNTNTHTRHTAGSSSNSKISQKARNQLALQQQQQYLAKHINSNGPQDKPKLQPLDFTTYSDTALLKYSERYGFHNFSRIDSLNSDILNSEIGKKTYSKRSKKNQKDTGRISKLEIANHVKNHFSSLPAKENDIITGFLYKVKHQDKEFKLTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNS1</accession>
    <name>A0A1D8PNS1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C503770CA</name>
        <name evidence="9" type="ordered locus">orf19.8714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29787.1"/>
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        <property type="nucleotide sequence ID" value="XM_706077.1"/>
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        <property type="interactions" value="500"/>
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    <dbReference type="STRING" id="237561.A0A1D8PNS1"/>
    <dbReference type="GeneID" id="3647233"/>
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        <property type="gene designation" value="orf19.8714"/>
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    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="130"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="244"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="5">
        <location>
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            <end position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
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            <position position="272"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000191596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="379" mass="42073" checksum="8142DA6CDEFB28C4" modified="2017-01-18" version="1">MGKPKVLMVLYSGGKHAKEEPRLLGTTENELGIRKLVEEHGYELVTTDDKDPYPTSTFDKNLPDAEIIITTPFFPAYVTKERIAKAPNLKLCITAGVGSDHYDLDALNERGVAVLEVTGSNVQSVAEHAIMTMLILLRNYGEGHAQATQGTWDIAAVAKDEFDMEDKVFATIGAGRIGYRILERLIAFNPKKLLYYDYQPLPEEAINKLNAASKLFNGVDNIIERVESLEDLVSQADVVTLNCPLYEKSKGMFNKELISKMKKGSYVINTARGALTDPQAIADAVNSGHIAYGGDVWPVQPAPKDMPWRTMHNPYGKDYGNAMTVHVSGTSLDAQARYANGVKQILTEYFDKTYKYRPQDVIIIDGHYATKAYGQRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPA3</accession>
    <name>A0A1D8PPA3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vam7p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C600240CA</name>
        <name evidence="8" type="ordered locus">orf19.8773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712300.1">
        <property type="nucleotide sequence ID" value="XM_707207.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PPA3"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C600240CA"/>
    <dbReference type="CGD" id="CAL0000193320">
        <property type="gene designation" value="orf19.8773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00240C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPA3"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="234"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000193320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34665" checksum="D5F017D763C1A267" modified="2017-01-18" version="1">MSTITIPQDIEIGGSTYYQINIKLPLRSFTIKKRYSEFQQLVSDLSRSLGIDSRDFPYELPGKRINWLNKTSIVEERKVGLAEFLNNLIQDSTLQNEREVLSFLQLPSNFRFTKDMLQNNRADLDSVQNNWYDVYRKLKSDILNESSSSISEQIHIRDRISRVYQPRILDLVRAIGTDKEEALKKKQLVSQLQESIDNLLVQEVPRSKRVLGGAVKETPETLPLNNKELLQHQVQIHQNQDKELDQLRVLIARQKQIGELINAEVEEQNEMLDRFNEEVDYTSSKIKQARRRAKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPF7</accession>
    <name>A0A1D8PPF7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C600770CA</name>
        <name evidence="2" type="ordered locus">orf19.11132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330992.1">
        <property type="nucleotide sequence ID" value="XM_019475447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPF7"/>
    <dbReference type="FunCoup" id="A0A1D8PPF7">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPF7"/>
    <dbReference type="GeneID" id="3647079"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600770CA"/>
    <dbReference type="CGD" id="CAL0000198284">
        <property type="gene designation" value="orf19.11132"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00770C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPF7"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000198284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="587" mass="66343" checksum="4BB804A0D583742B" modified="2017-01-18" version="1">MEPTPLIELSDDEDEIDFKVNITRKPISLTTNEPEVIELLSDSCTEDPPILTSIQSSQTKDFRSSPNPKPNQTFISTNNQTSISKPTYTSTEQITDVIVIESDEEETSIVQKISGTSKIVASTRLPSSPVSIANQEPEKTMNDSIVDSSFSFSMDNLVTTIRNGGPKLSSSKPVSQPVSAGSGLSSGPNPVSSSFKMPPFVKWLSSDDDDDDEKEEDPIVPTSQPVPHETNFDAQPAKRSRTVQEPPQSAPKPVKRSKTVDQVIDLPRIDNFQYTSKDLKEANRATRKKEELLAEMELHMAESVYSRLEDLVKDFQSRVIKASYTLPVIFWKRNINAAYDKERDIFIPCHPRRVLEKTFVLYYHASVFFEKLRNHTLKVDVSAAKQQALAITPNEYNVILVVEGYDILLNKIKAYEQRLFKNQVLQGLNVEEQRRRRKDDTEMSKYPSSSEIEHLVNKAQIDLKANIFMVRAKQESIMWLNSFTHMIGQSLYDKFERNQGLANLGNVKSGADTKSTFLQSMKQFNLMTQAKADILYVSHQSLHSMYTKLRSHGTLGKDNLKRNIVPPSVDSSMKKFFTADDPDMVIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPK1</accession>
    <name>EBP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable NADPH dehydrogenase</fullName>
            <ecNumber evidence="1">1.6.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Estrogen-binding protein</fullName>
            <shortName evidence="1">EBP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EBP1</name>
        <name evidence="5" type="ordered locus">orf19.125</name>
        <name evidence="6" type="ORF">CAALFM_C601180CA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Cell Rep." volume="38" first="110183" last="110183">
            <title>Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system.</title>
            <authorList>
                <person name="Kumwenda P."/>
                <person name="Cottier F."/>
                <person name="Hendry A.C."/>
                <person name="Kneafsey D."/>
                <person name="Keevan B."/>
                <person name="Gallagher H."/>
                <person name="Tsai H.J."/>
                <person name="Hall R.A."/>
            </authorList>
            <dbReference type="PubMed" id="34986357"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2021.110183"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Oxidoreductase that binds mammalian estrogens with high affinity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>A + NADPH + H(+) = AH2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:13149"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="induction">
        <text evidence="3">Induced by estrogen (17beta-estradiol).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Decreases phagocytosis of the fungus by host cells (PubMed:34986357). Increases expression of GPD2 (PubMed:34986357).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714331.2">
        <property type="nucleotide sequence ID" value="XM_709238.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPK1"/>
    <dbReference type="SMR" id="A0A1D8PPK1"/>
    <dbReference type="FunCoup" id="A0A1D8PPK1">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPK1"/>
    <dbReference type="EnsemblFungi" id="C6_01180C_A-T">
        <property type="protein sequence ID" value="C6_01180C_A-T-p1"/>
        <property type="gene ID" value="C6_01180C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644060"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601180CA"/>
    <dbReference type="CGD" id="CAL0000199513">
        <property type="gene designation" value="EBP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01180C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPK1"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099130">
        <property type="term" value="F:estrogen binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0000314"/>
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    </dbReference>
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        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
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    </dbReference>
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    <keyword id="KW-0285">Flavoprotein</keyword>
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    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
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            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
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        <ligand>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000199513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30064.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="407" mass="46089" checksum="9E19211953CA83D5" modified="2017-01-18" version="1">MTIESTNSFVVPSDTELIDVTPLGSTKLFQPIKVGNNVLPQRIAYVPTTRFRASKDHIPSDLQLNYYNARSQYPGTLIITEATFASERGGIDLHVPGIYNDAQAKSWKKINEAIHGNGSFSSVQLWYLGRVANAKDLKDSGLPLIAPSAVYWDENSEKLAKEAGNELRALTEEEIDHIVEVEYPNAAKHALEAGFDYVEIHGAHGYLLDQFLNLASNKRTDKYGCGSIENRARLLLRVVDKLIEVVGANRLALRLSPWASFQGMEIEGEEIHSYILQQLQQRADNGQQLAYISLVEPRVTGIYDVSLKDQQGRSNEFAYKIWKGNFIRAGNYTYDAPEFKTLINDLKNDRTIIGFSRFFTSNPDLVEKLKLGKPLNYYNREEFYKYYNYGYNSYDESEKQVIGKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPZ7</accession>
    <name>A0A1D8PPZ7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
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    <gene>
        <name evidence="10 11" type="primary">MIF2</name>
        <name evidence="11" type="ordered locus">CAALFM_C602780CA</name>
        <name evidence="10" type="ordered locus">orf19.12997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_714021.2"/>
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    <dbReference type="SMR" id="A0A1D8PPZ7"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S47H">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Centromere protein C 1"/>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
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        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
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        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="426"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000174202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="520" mass="58396" checksum="7BD222DF74A03120" modified="2017-01-18" version="1">MYLSNLGGQSRKTGIRPKTNLKTDKYGMEDVDDFFEDDDDDGINKSKGQKSTIALSRGEEVSNYKSTISQPFNNIARKINFNQEDDETFNLPSTSSSSATVTASSVSNKKSPVTTQQSPLRSPLPEQDYDYNQFDVEEDYGNITEEDKQPSPPPPVPKTKSKAKTKAKASTTNNTNTKSTKAASSFTKKMALGKTKRLPSSFDSVNTSSVTEYYDEDDEDNDRDYGESQQDSIEDSMVDSTFNDYSQPSSNNNKTRRKIIKESPLPSPPPDNPNGLRRSKRTRIKPLAFWRNERIIYSKDLDYDDEQDTTLARDIHNIPLQSIKEVVHIPDNESVDNSGSPNTRTGAAGSTKTRSNRKRTYKQTTTTAPTDYDYESDPEISGSEWFKEDNLSLEVNDNGESKLRKIAYNHKGGNYVKPTDDNYLVASLFDEDKSFFAGGMLQLPSDGFKPPVTVTGSTYMFNVMKGLIQVTLNENMFVVTKGCKVQIPEGNEYSLRNIGQGDAYLFFVQIRKPEEIDTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQA3</accession>
    <name>A0A1D8PQA3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U2 snRNP complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C603910CA</name>
        <name evidence="4" type="ordered locus">orf19.13190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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            <dbReference type="CGD" id="CAL0000186095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="861" mass="97826" checksum="8BDEEDB73E28122F" modified="2017-01-18" version="1">MSGSFWKFSNGFTSLSNISTLLENYNRDSESGKVEEEGQLEVLKKLLDENDLLQELLSNNPMLMSFLREDKILGMLVNLVILEGAVDEDNPSIKDSKNKIDTKESTSDRKTVEKKSSKSDSKKDKTVDNVKEKGDEKEKGDEKDNEEEDDDEDDDDDDEEKNDEIDEQDLEESAEQKATRRATIAAEILSADVWSLTDAVMASTENLNRLWEILDDKEPLSISLSTYFMKIMEHLLDMKCEDMITYLIENQPNLVEKFVNHLSNPPLMDFLLKLISTDKPDNSTGIIDFLQNQDLITHLVDALDISGGKEEDYEMLLVRQSSTADFLKALITISANSTTDNSTIGPNELTRELVSHEQMKRLCNIMLKGGYALANGVGIIIEIIRKNNSDYDVVPILHIRLENHPPTGRDPIYLGYLLRVFGEKIEEFNKLLIKEDPDCKLRTPFGDIEPLGFERFKICELIAELLHCSNMALLNENRGFDIVKERDELRIKMKEFDPISFKYNETIVLPDDDNNNDNSNNNNNNNTASNANDTIDDFNADDSIDEEEPHANANLTEEQLRSSPVVGDFLKIALFDTQIISNILSMFFRFPWNNFLHNVVFDIVQQVLNGSMEIGFNKFLAIDLFASGDITNKIIEGQKLCADYESSHNGLRLGFMGHLTLIAEEVVKFVQLYPSNTLSDLIDIKVESDVWEEYVNNVLYDTREKYNAILGGGDEDDEDDEEDDENTTFEEGLGEIIEEVKTGLVFEEPQKKKDFLDGDESGSDDDDHFSNYMSQQLTNPSTTPNHEHEDELETSSEDDEDEEEYIDPNDDGRSYKKSNSLYDSKGSLKKPENEDEISDESDSSDEEEKQDTKLTRSASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRE2</accession>
    <name>A0A1D8PRE2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">PNC1</name>
        <name evidence="10" type="ordered locus">CAALFM_C703520WA</name>
        <name evidence="9" type="ordered locus">orf19.13976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712137.2">
        <property type="nucleotide sequence ID" value="XM_707044.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRE2"/>
    <dbReference type="SMR" id="A0A1D8PRE2"/>
    <dbReference type="FunCoup" id="A0A1D8PRE2">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRE2"/>
    <dbReference type="GeneID" id="3646232"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703520WA"/>
    <dbReference type="CGD" id="CAL0000183035">
        <property type="gene designation" value="PNC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03520W_A"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRE2"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904524">
        <property type="term" value="P:negative regulation of DNA amplification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006769">
        <property type="term" value="P:nicotinamide metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.850:FF:000013">
        <property type="entry name" value="Pyrazinamidase and NiCotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000183035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="244" mass="27878" checksum="97D9511E73A37D5C" modified="2017-01-18" version="1">MKKTALIVVDLQEDFLPPNGSLAIKNGRSVIPKINQLLPSQDNHSKFDWSLIVATQDWHPPNHTSFASQHENVAPFTEIEFIHPEKKLDPKTNQPIVMNQIVWPDHCVQGTKGAQLEPSFANQFEKLTKQDDNNTAPCKIVKKGYLPDREYYSCFQDCWGLHHTELIDLLHEYDIENVVFVGLAYDFCVLSSAIDSAKNGFKTFVLKNYCESVYPEKINDTDKLFIDNGVTIVDNDEKFDSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRE6</accession>
    <name>A0A1D8PRE6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAALFM_C703470WA</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711669.2">
        <property type="nucleotide sequence ID" value="XM_706577.2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRE6"/>
    <dbReference type="GeneID" id="3646711"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703470WA"/>
    <dbReference type="InParanoid" id="A0A1D8PRE6"/>
    <dbReference type="OrthoDB" id="4021105at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AOW30690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="225" mass="25997" checksum="977AFE9D60BEC39A" modified="2017-01-18" version="1">MYTIIQKIKWPLVLCDFVFKNFNTNYRTLELLNLKESRLQEIRFSGGHVKELSIDLFPVSVENLTLMEMGIHELSASFESLKNLYRLSLMGNQLRNVNSVKLPVSSLEVLNVRQCNLRLISPFLVSMLEEKNQNANLRVEATGNLNVNINDXRKVMKAIKGLSLELNRLNDSILKISNHSYRLEAVYRDFDPYFETPQSSETEEVVSDYDSDDLYNGSVFYSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRF6</accession>
    <name>A0A1D8PRF6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C703760WA</name>
        <name evidence="1" type="ordered locus">orf19.5502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710530.1">
        <property type="nucleotide sequence ID" value="XM_705438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRF6"/>
    <dbReference type="GeneID" id="3647865"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703760WA"/>
    <dbReference type="CGD" id="CAL0000177515">
        <property type="gene designation" value="orf19.5502"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03760W_A"/>
    <dbReference type="eggNOG" id="ENOG502RQ8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRF6"/>
    <dbReference type="OMA" id="FFEIKDP"/>
    <dbReference type="OrthoDB" id="3997115at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000177515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="245" mass="26687" checksum="AFF2717493F14B0C" modified="2017-01-18" version="1">MKRNNSESQLLYYYNNTTPTATANPTANPTVTTLSLSTSSPTTNTIVKKFKTREFINKPPSNYISLNNASIIPINILQLLNSINPMNDDSTSSSSSSSSSCYFKFIFFLGAQGKEFIPTIQYQFPFNISVTFITSNNDSSGGGSSGGGSSGGGGGGGCGCTNDQCKQLMKFFEIKDPMGAGLYPLDYLIIIHQNKVHCKIPIKFNNNSTYTKHFKVVGGMSGHLKFGIDLNELPSLIEEYINYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRI2</accession>
    <name>A0A1D8PRI2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ENV7</name>
        <name evidence="13" type="ordered locus">CAALFM_C704110WA</name>
        <name evidence="12" type="ordered locus">orf19.7164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715213.1">
        <property type="nucleotide sequence ID" value="XM_710120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRI2"/>
    <dbReference type="SMR" id="A0A1D8PRI2"/>
    <dbReference type="FunCoup" id="A0A1D8PRI2">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRI2"/>
    <dbReference type="GeneID" id="3643133"/>
    <dbReference type="KEGG" id="cal:CAALFM_C704110WA"/>
    <dbReference type="CGD" id="CAL0000190373">
        <property type="gene designation" value="ENV7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_04110W_A"/>
    <dbReference type="eggNOG" id="KOG2345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRI2"/>
    <dbReference type="OMA" id="AMHQYKV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001663">
        <property type="entry name" value="Putative serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000860">
        <property type="entry name" value="Serine/threonine-protein kinase ENV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000190373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW30749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="364" mass="41229" checksum="41D39834A9CC193B" modified="2017-01-18" version="1">MDVLLSIFGTCLPCFPTLSSPSIIINNNKYRIIRLLGEGGFSYVYLVSSQSQPSSQYALKKIRCPYGIQDESFKNAVREIKNYHRFKSPYIISSIDELIQSETDGSKNIYILLPFFQKSLQDIINELVLNNSKMEESEILRVFIGTCRGLKVMHNHKKTATSTTRLDDDEQDVLLPTSEDDEYEDFTNSTDNNNNNNVQMQELVPFAHHDLKPANVMLSAEGLPVLCDLGSCSRARISVRNRQQALTVQEFAQEHCTLPYRAPELVDVATNCEITEKTDIWSLGCLLYCCCFGYSPFEKLEIEQGANLNLAILQGKYEIPKGNNGYDSKLIELIKKCLQLNPDSRPDIDELLNDVLELTRQLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRR3</accession>
    <name>A0A1D8PRR3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">NTH1</name>
        <name evidence="9" type="ordered locus">CAALFM_CR00560WA</name>
        <name evidence="8" type="ordered locus">orf19.7479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718636.1">
        <property type="nucleotide sequence ID" value="XM_713543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRR3"/>
    <dbReference type="SMR" id="A0A1D8PRR3"/>
    <dbReference type="FunCoup" id="A0A1D8PRR3">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRR3"/>
    <dbReference type="GeneID" id="3639665"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00560WA"/>
    <dbReference type="CGD" id="CAL0000200632">
        <property type="gene designation" value="NTH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00560W_A"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRR3"/>
    <dbReference type="OMA" id="WLFMMTK"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="term" value="F:trehalase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
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        <property type="project" value="CGD"/>
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        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
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    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="39"/>
            <end position="172"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
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            <begin position="111"/>
            <end position="120"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00005615"/>
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    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000200632"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="907" mass="104072" checksum="9711101A6B941C6E" modified="2017-01-18" version="1">MFTKNHRRMSSTSSDDDPFDVAEKYYGEERKKKLNRVRTFSAFESTKYGAGPISPLRPTYEPPPVIKETSEPLSSSSSTSSPPTLTPQTSQVQFNLGVGKTKNGSAIHSDSEEEEEDEDPVSNTKKGEADEKDPFDTTDSKLENENSTPSSITGKEIIPHPTGFRGSSEESAIRRKPSIIPIYHDNISQESVIRNANTPTTYNREKFHLRRGSLDESTFIRPKKYYINDVQGTLRELLANEDTDNNCQITIEDTGPKVLRLGTANSLGINQSSIRGTYRLSNLLQELTIASRFGRHQIVLDEARLSENPVDRMKRLISTSFWNNLTRIITKENIVDMAKDTKIKESWIDDQGKLHENQESHRIYVPYNRKDQYEFFQLIKKQRSDIQLDVQYLPQKIDADYIKSINKKPGLLSIATRPDPQAPDSGSLISWPYVVPGGRFNELYGWDSYMETLGLLTDVKIDPSGNPRNLRHLELARGMAENFIYEIHHYGKILNANRSYYLGRSQPPFLTDMALRIFNKTIEVTPELMDEAIDFLKRATLAAIKEYETIWCAHPRLDDKTGLSCYHPEGKGIPPETEPTHFNALLKPYLAKYNDIDQLDFIEKYNSGEIKEPELDEYFLHDRAVRESGHDTSYRLEGKCAYLATVDLNSLLYKYENDIAFILQSFFNDNLQDPYDDNNSYKIHSSKIWLERSHQRKLNVDKYLWNEQDGIYYDYNVKLQQQTNYESATTFWPLYAKLASSNQAAKLIDQSLHKFEEHGGLVAGTLKSRGEVGLTRPSRQWDYPFGWAPQQILAWIGLVNYGYDGIARRLAYRWLFMMTKSFVDYNGVIVEKYNVTKGAVPHRVDAEYGNQGLDFKGVATEGFGWVNASYVFGLTFLNLYAQRALGSLTPPEIFLRNMHPEQRKQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS32</accession>
    <name>A0A1D8PS32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR01820WA</name>
        <name evidence="10" type="ordered locus">orf19.10114</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718248.2">
        <property type="nucleotide sequence ID" value="XM_713155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS32"/>
    <dbReference type="SMR" id="A0A1D8PS32"/>
    <dbReference type="FunCoup" id="A0A1D8PS32">
        <property type="interactions" value="1050"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS32"/>
    <dbReference type="GeneID" id="3640164"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01820WA"/>
    <dbReference type="CGD" id="CAL0000200790">
        <property type="gene designation" value="orf19.10114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01820W_A"/>
    <dbReference type="eggNOG" id="KOG2030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS32"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904678">
        <property type="term" value="F:alpha-aminoacyl-tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140708">
        <property type="term" value="P:CAT tailing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043043">
        <property type="term" value="P:peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="567"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="889"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000200790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116829" checksum="6B77B803038A69D3" modified="2017-01-18" version="1">MKQRITGLDLQILTSELSKELSNYRLQNIYNVASNSRQYLFKFSIPDSKKVVVLEYGNRIHLTDFERPTTQQPTNFVTKLRKHLKTRRLSGIKQISNDRILVLEFSDGKYYLVLEFFSAGNILLLDESQRILALQRLVSAKQENDRYAVNEEYKMFDKSLFQQDFHYEKRSYDLDEVESWIQTHKLKLSQNSDNKKAKVFSIHKLAFINASHLSGELIQKWFFESGIDPSQSCLSFEKNQEALQRVVNALGVCEDKYIDLINGAIATEGYIVAKKNNKVSEKSDLEYIYDEFHPFEPYKPNQEGIKFISVSGYNKTLDKFFSNIESTKFSMKIEQQKENAAKRLEKARSERDKQIDSLVAQQRLNAKKGELIQYHSELVEECRSYVQSFIDQQMDWTNIETVISLEQKKKNELAQHIQLPLNLKENKIKVLLEDFDDYEEITESASATETGSETETESESESSSESESDNDEDKIPVKRTQRKTNTKEKPKRKTIPTWIDLSQSAFANARSYFDSKKTAETKQVKVENSTSMALKNAERKITQDLTRSLKQENDTLKEIRPKYWFEKFFWFVSSEGYLCLAGKDASQTDMIYYRHFSDNDSIVSADMEGSLKVFIKNPLKGEALPPSTLMQAGIFAMSASSAWNGKVTTSAWVLHGTEISKRDFDGSIVPEGEFNYLVQKEYLPPAQLVMGFGFYCLLDDESTKRYGEIRTKRELEHGFAIVVDNKKKELEEIRLAQKASAKENTAQEQRVDESSESDDNEDDGGEDADSPDTDTVSVDANGEEKPVIVQQLPRGKRSKLKKIAAKYRDQDEEERKLRMDALGTLKQVEERLSKTQIENSEKSESVKKQQQKEVILERKKKQKERELQKYLLGDDNNDEETNNESHIVNYLEILDSFTAKPSTKDTIVGLVPVFAPWSALQKFKYKVKIQPGSGKKGKCIGDSINYFVNRKMDSSSRDVDLDWPQEREFINNFKTNDIVGIFTVGKVKLVLPGGSGDSNKSGKSNNKKPASKKGNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSX6</accession>
    <name>A0A1D8PSX6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hgt9p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">HGT9</name>
        <name evidence="11" type="ordered locus">CAALFM_CR05090CA</name>
        <name evidence="10" type="ordered locus">orf19.8258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331088.1">
        <property type="nucleotide sequence ID" value="XM_019475543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSX6"/>
    <dbReference type="SMR" id="A0A1D8PSX6"/>
    <dbReference type="STRING" id="237561.A0A1D8PSX6"/>
    <dbReference type="GeneID" id="3646404"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05090CA"/>
    <dbReference type="CGD" id="CAL0000199955">
        <property type="gene designation" value="HGT9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05090C_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSX6"/>
    <dbReference type="OMA" id="YMSLITD"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000199955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="573" mass="62826" checksum="E1AB84EC8490DCB6" modified="2017-01-18" version="1">MSKGDLEELDIQKLIVEKRLEQSNGSGFATMKRNKRALGTCLFVSLGGILYGYNQGMFGQVSSMHSFGETVGIGKIQDNPTLQGLLTSILELGAWVGVLMNGYVADALGRRASVVIGCILFNIGVIIQAVARDADYGYILGGRFVIGLGVGVLSMVVPLYNSEISRAEIRGANTAIYQLSITFGIMISYWITYGTNFIGGTGDNQSQASWLVPMCIQAAPAIILAVFIYSFPESPRWLINVGQEDKALEVLAWLRETEQENVGLQIEFLEMKAQKIFEQTLETEAYPHLQDGTKMSKFKINLNQYKSMVTHLPTFKRVSVACLTMVFQQWTGANFILYYAPFIFASLGLSGNTTSLLASGVVGIVMFLCTIPAVMWVDKVGRKPLLISGALVMGLCHFVVAGILGGYSDNIGSHKAAGWVAVVFIWIFAGAFGYSWGPCAWVIVAEVFPLGMRAKGVSLGSSFNWLMNFSVAISTPKFVANAKYGAYIFLGLMCVIGSMYVYFMVPETKNKTLDELDEVFGDFTGTSKKESELREKILKQVGLVDLLVGSDKELDSFRSKPEVEYKEKEAHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT80</accession>
    <name>A0A1D8PT80_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_CR06520CA</name>
        <name evidence="5" type="ordered locus">orf19.8333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713074.1">
        <property type="nucleotide sequence ID" value="XM_707981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT80"/>
    <dbReference type="SMR" id="A0A1D8PT80"/>
    <dbReference type="FunCoup" id="A0A1D8PT80">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PT80"/>
    <dbReference type="GeneID" id="3645263"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06520CA"/>
    <dbReference type="CGD" id="CAL0000189481">
        <property type="gene designation" value="orf19.8333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06520C_A"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT80"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000185383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="77597" checksum="F36AB7B9E7FB2C0B" modified="2017-01-18" version="1">MGIFSSLDASIDGDEYIQKLATYIRKNEESLANGLLCFSKIQENQPSLSKIKPLRLSFTMHHLYYITERISRSSLDVDVGPLNIKSDNPNHEPTFISFMANKSRSSNRHFDSDNRSITSIDSVRSIVSNASFYWRSFRVSKDPKVINKDIKYLYSSFTKIPCLIFNPKTKINTISSYEEYPCDTSVPIQMFKNLQVLEIIEYDPNEIFGWHILSEQLRILIIRKANITSVEEVMFQLVDDDALGRQSFNSTSSSLSSSSFSSAGISRANTITANSTIPENASFYSNHNKFRPKKTYTTNNGLERINSRHSTGKNKATSSSSSTSRDTRWSLLKQLTISETSISSVNRQSFKNLTNLVKLNLSSNLLESVPEGLEQLTNLRYLNLADNKITNLKGVENIISLIKLDIRKNPIKNLQPLIKLATKTQYQVYISSASTSSSSSSSSSIPIDSMRLLELEIGLRQKVKKHQSLSQNVISTSSSEMKLSSITTSKPNHEANNNTTTTTTTTTNFDPNPNHNHNNSIDKSITTKPTTTTTNTKNQNSTTNINHSPSLKSISISTDNNISSDKGIVSKPTTTTSSTTTPSTTSTTTPTMAKSPRFSSQFMHHLNDSNSSIPSNNSIKRSTTSSTLIDHEHNNNHSDGTSNSNSNSNNNGSSNSNSNGNSNGNSNGNSNGNSNGNSNNNNNNNNGAAPNIVTTVQVTVHMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU74</accession>
    <name>A0A1D8PU74_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">SPT3</name>
        <name evidence="9" type="ordered locus">CAALFM_CR10450CA</name>
        <name evidence="8" type="ordered locus">orf19.7622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719383.1">
        <property type="nucleotide sequence ID" value="XM_714290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU74"/>
    <dbReference type="SMR" id="A0A1D8PU74"/>
    <dbReference type="FunCoup" id="A0A1D8PU74">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU74"/>
    <dbReference type="GeneID" id="3638977"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10450CA"/>
    <dbReference type="CGD" id="CAL0000183199">
        <property type="gene designation" value="SPT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10450C_A"/>
    <dbReference type="eggNOG" id="KOG3902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU74"/>
    <dbReference type="OMA" id="QFMFNEQ"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000183199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="328" mass="38127" checksum="54942F52B41813DB" modified="2017-01-18" version="1">MASDNKYKYRIEISQMMFVSGEANDPPIETTSIIEDIVRGQVIEILRQSTKTANSRGSRSIIPEDVIFLIRHDKAKVNRLRTYLSWKDVRKNAKDQEGGGTESLIENTNDVGVGAGGPSQSQSNDSSKMLSRYKKSKIRLPWELQFMFSEQHLETQEENELIDDEEKAASIARLKKLKMADDRTKNMTREEYVHWSECRQASFTFRKGKRFREWAQMSQLCDTRPNDDVIDILGFLTFEIVCSLTEEAMNIKNSEDKLHHIQRLKQIVDNKEKPVKRKYLFDKPDEFTTPIMPYHIEEAWRRLQSTDFKHKAARAFGGGVLKTRTRLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>P78595</accession>
    <accession>A0A1D8PK27</accession>
    <accession>Q5ANE5</accession>
    <name>CDR2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Multidrug resistance protein CDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDR2</name>
        <name type="ordered locus">CAALFM_C304890WA</name>
        <name type="ORF">CaO19.13379</name>
        <name type="ORF">CaO19.5958</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Microbiology" volume="143" first="405" last="416">
            <title>Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.</title>
            <authorList>
                <person name="Sanglard D."/>
                <person name="Ischer F."/>
                <person name="Monod M."/>
                <person name="Bille J."/>
            </authorList>
            <dbReference type="PubMed" id="9043118"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Multidrug efflux transporter. Confers resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U63812">
        <property type="protein sequence ID" value="AAB96797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723169.1">
        <property type="nucleotide sequence ID" value="XM_718076.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P78595"/>
    <dbReference type="SMR" id="P78595"/>
    <dbReference type="BioGRID" id="1218359">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="FunCoup" id="P78595">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P78595"/>
    <dbReference type="BindingDB" id="P78595"/>
    <dbReference type="ChEMBL" id="CHEMBL1163105"/>
    <dbReference type="TCDB" id="3.A.1.205.5">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_04890W_A-T">
        <property type="protein sequence ID" value="C3_04890W_A-T-p1"/>
        <property type="gene ID" value="C3_04890W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635265"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304890WA"/>
    <dbReference type="CGD" id="CAL0000197349">
        <property type="gene designation" value="CDR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04890W_A"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="P78595"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphatidylcholine floppase activity"/>
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        <property type="term" value="F:phosphatidylethanolamine floppase activity"/>
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        <property type="term" value="F:phosphatidylserine floppase activity"/>
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        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
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    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC transporter CDR4"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="ABCG_PDR_1"/>
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        <property type="entry name" value="ABCG_PDR_2"/>
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        <property type="entry name" value="Drug-R_PDR/CDR"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
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    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC2_membrane"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000093436" description="Multidrug resistance protein CDR2">
        <location>
            <begin position="1"/>
            <end position="1499"/>
        </location>
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    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="784"/>
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    <feature type="binding site" evidence="2">
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        <ligand>
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    <feature type="sequence conflict" description="In Ref. 1; AAB96797." evidence="3" ref="1">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="15"/>
        </location>
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    <feature type="sequence conflict" description="In Ref. 1; AAB96797." evidence="3" ref="1">
        <original>A</original>
        <variation>G</variation>
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            <position position="475"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB96797." evidence="3" ref="1">
        <original>M</original>
        <variation>S</variation>
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            <position position="788"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000305" key="3"/>
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</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2025-06-18" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>P83777</accession>
    <accession>A0A1D8PI90</accession>
    <accession>Q59Y59</accession>
    <accession>Q59YB5</accession>
    <name>IPYR_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Inorganic pyrophosphatase</fullName>
            <ecNumber>3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pyrophosphate phospho-hydrolase</fullName>
            <shortName>PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IPP1</name>
        <name type="ordered locus">CAALFM_C208810CA</name>
        <name type="ORF">CaO19.11072</name>
        <name type="ORF">CaO19.3590</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proteomics" volume="4" first="3084" last="3106">
            <title>Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Abian J."/>
                <person name="Carrascal M."/>
                <person name="Sanchez M."/>
                <person name="Nombela C."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="15378761"/>
            <dbReference type="DOI" id="10.1002/pmic.200400903"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 186-192</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ANTIGENICITY</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
            <tissue>Protoplast</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714437.2">
        <property type="nucleotide sequence ID" value="XM_709344.2"/>
    </dbReference>
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        <property type="interactions" value="2"/>
    </dbReference>
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        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P83777"/>
    <dbReference type="EnsemblFungi" id="C2_08810C_A-T">
        <property type="protein sequence ID" value="C2_08810C_A-T-p1"/>
        <property type="gene ID" value="C2_08810C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643874"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208810CA"/>
    <dbReference type="CGD" id="CAL0000192002">
        <property type="gene designation" value="IPP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08810C_A"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040684_0_1_1"/>
    <dbReference type="InParanoid" id="P83777"/>
    <dbReference type="OMA" id="LYANEQK"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="PRO" id="PR:P83777"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137580" description="Inorganic pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
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            <position position="122"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
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            <position position="122"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>2</label>
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    <feature type="binding site" evidence="1">
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            <position position="154"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15378761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="288" mass="32144" checksum="3EFBB85446F5D1C3" modified="2017-03-15" version="3">MSSYSTRQVGAANTLDYKVYIEKDGKLVSPFHDIPLYANEEKTILNMIVEVPRWTNAKLEISKEQKLNPIIQDTKKGKLRFVRNCFPHHGYIHNYGAFPQTWEDPNQSHPETKAKGDNDPLDVCEIGEKVATVGEVKQVKVLGVMALLDEGETDWKVIVIDVNDPLAPKLNDIEDVETHLPGLLRATNEWFRIYKIPDGKPENQFAFSGECKNKKYAEEVIGECAEAWEKLIKGESVDSKGIDLTNTTLSSTPSYSDAAAQEIPSASPAPAAPIDKSIDKWFFISGAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KI0</accession>
    <accession>A0A1D8PST7</accession>
    <name>UGP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber>2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>UDP-glucose pyrophosphorylase</fullName>
            <shortName>UDPGP</shortName>
            <shortName>UGPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">UGP1</name>
        <name type="ordered locus">CAALFM_CR04660CA</name>
        <name type="ORF">CaO19.1738</name>
        <name type="ORF">CaO19.9305</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Proteomics" volume="7" first="686" last="697">
            <title>Proteomic analysis of the oxidative stress response in Candida albicans.</title>
            <authorList>
                <person name="Kusch H."/>
                <person name="Engelmann S."/>
                <person name="Albrecht D."/>
                <person name="Morschhauser J."/>
                <person name="Hecker M."/>
            </authorList>
            <dbReference type="PubMed" id="17285563"/>
            <dbReference type="DOI" id="10.1002/pmic.200600575"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="FEBS Lett." volume="544" first="228" last="235">
            <title>Identification of cell surface determinants in Candida albicans reveals Tsa1p, a protein differentially localized in the cell.</title>
            <authorList>
                <person name="Urban C."/>
                <person name="Sohn K."/>
                <person name="Lottspeich F."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="12782322"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(03)00455-1"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Int. J. Med. Microbiol." volume="298" first="291" last="318">
            <title>A proteomic view of Candida albicans yeast cell metabolism in exponential and stationary growth phases.</title>
            <authorList>
                <person name="Kusch H."/>
                <person name="Engelmann S."/>
                <person name="Bode R."/>
                <person name="Albrecht D."/>
                <person name="Morschhauser J."/>
                <person name="Hecker M."/>
            </authorList>
            <dbReference type="PubMed" id="17588813"/>
            <dbReference type="DOI" id="10.1016/j.ijmm.2007.03.020"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="896" last="904">
            <title>Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo.</title>
            <authorList>
                <person name="Fanning S."/>
                <person name="Xu W."/>
                <person name="Solis N."/>
                <person name="Woolford C.A."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22544909"/>
            <dbReference type="DOI" id="10.1128/EC.00103-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="Eukaryot. Cell" volume="12" first="875" last="888">
            <title>Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/alpha biofilms.</title>
            <authorList>
                <person name="Srikantha T."/>
                <person name="Daniels K.J."/>
                <person name="Pujol C."/>
                <person name="Kim E."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="23563485"/>
            <dbReference type="DOI" id="10.1128/EC.00071-13"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
        <text>Localizes to yeast but not hyphal cell surface.</text>
    </comment>
    <comment type="induction">
        <text evidence="6 7 8 9">Expression is up-regulated during oropharyngeal candidiasis (OPC) infection and during stationary phase. Repressed by HOG1, BCR1 and hydrogen peroxide.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Present with 17200 molecules/cell in log phase SD medium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331084.1">
        <property type="nucleotide sequence ID" value="XM_019475539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KI0"/>
    <dbReference type="SMR" id="Q59KI0"/>
    <dbReference type="FunCoup" id="Q59KI0">
        <property type="interactions" value="956"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59KI0"/>
    <dbReference type="EnsemblFungi" id="CR_04660C_A-T">
        <property type="protein sequence ID" value="CR_04660C_A-T-p1"/>
        <property type="gene ID" value="CR_04660C_A"/>
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    <dbReference type="GeneID" id="3648144"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04660CA"/>
    <dbReference type="CGD" id="CAL0000175518">
        <property type="gene designation" value="UGP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04660C_A"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="Q59KI0"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="PRO" id="PR:Q59KI0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:glycogen biosynthetic process"/>
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        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
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        <property type="project" value="CGD"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
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        <property type="entry name" value="Intein_N"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
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    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
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    <dbReference type="Pfam" id="PF01704">
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    <dbReference type="PIRSF" id="PIRSF000806">
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    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000424335" description="UTP--glucose-1-phosphate uridylyltransferase">
        <location>
            <begin position="1"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Oligomerization" evidence="2">
        <location>
            <begin position="449"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="388"/>
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    <feature type="binding site" evidence="4">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
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        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q16851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q9M9P3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12782322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17285563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="17588813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="22544909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="23563485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <sequence length="500" mass="55552" checksum="476B07B548695192" modified="2017-03-15" version="2">MATTGKRHAKSQSTYAFDNTATNVTASQMRNALNNLADTVENPEQTTRFENEMDNFFTLFRRYLTEKASGSTLDWDKIRSPSSDEVVEYGDLNSANNSANLSKLAVLKLNGGLGTSMGCVGPKSVIEVRDGNNFLDLAVRQIEHLNRKYDADVPLLLMNSFNTDADTEKIIKKYQSHRIRVKTFNQSRFPRIYKDSLLPVPESFDDSLEAWYPPGHGDLFEALVQSGELDALLAQGREILFVSNGDNLGATVDSKILDHMIETGAEYIMELTPKTRADVKGGTLINYQGEVRLLEIAQVPKEHVEEFKSIKKFKYFNTNNLWINLRAIKKLVEANAIEVEIIPNQKTISHGKSDINVLQLETAVGAAIRHFKGAHGVVVPRSRFLPVKTCSDLLLVKSDLFYLEHGALVLDPTRDGFSNPLIKLGSHFKKVSGFQSRIPYIPKILELDHLTITGNVTIGKGVQLKGTVIIVCNDGDKIDIPNGAILENVVVTGNLTILEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KY7</accession>
    <name>Q59KY7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C104370CA</name>
        <name evidence="6" type="ordered locus">orf19.12668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710409.1">
        <property type="nucleotide sequence ID" value="XM_705317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KY7"/>
    <dbReference type="SMR" id="Q59KY7"/>
    <dbReference type="STRING" id="237561.Q59KY7"/>
    <dbReference type="GeneID" id="3647994"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104370CA"/>
    <dbReference type="CGD" id="CAL0000192931">
        <property type="gene designation" value="orf19.12668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04370C_A"/>
    <dbReference type="eggNOG" id="KOG3162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082177_1_0_1"/>
    <dbReference type="InParanoid" id="Q59KY7"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000192931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="200" mass="22464" checksum="80D34AE97F427A34" modified="2005-04-26" version="1">MLSSLRLSSIRAVNSGSIRFVSSTVPKLNAKLSVGDSNDTSSKTNIDDMKSKTSWNESYASGSSIQVNLNENLNKITENISSSDPPIYVSPNLHRHFTMGDTYNPFDFSMNRFDMEKKMKSTKKLSDPFEKSGIDPKNLYLMPEILSKFLTSTGQILPRQVTGCNAKNQKRLSMAIEYARSLGLLSSQHRHARYMPTRNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LS1</accession>
    <name>RL3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPL3</name>
        <name type="ordered locus">orf19.1601</name>
        <name type="ORF">CAALFM_C209430WA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPL3 plays a role in coordinating processes of accommodating the aminoacyl-tRNA in the PTC.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710682.1">
        <property type="nucleotide sequence ID" value="XM_705590.2"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8CQ7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8CQW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.05 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8CRE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8OEQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="AX/k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="8Q5I">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="k=1-389"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
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            <taxon>Candida</taxon>
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            <title>The diploid genome sequence of Candida albicans.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="2">
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                <person name="van het Hoog M."/>
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            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="3">
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                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    </reference>
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            <dbReference type="PubMed" id="12388749"/>
            <dbReference type="DOI" id="10.1091/mbc.E02-05-0272"/>
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        <scope>INDUCTION</scope>
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        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1128/EC.3.5.1076-1087.2004"/>
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        <scope>INDUCTION</scope>
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            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
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                <person name="Lan C.Y."/>
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            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
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        <scope>INDUCTION</scope>
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    <reference key="8">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="1837" last="1843">
            <title>Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin.</title>
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                <person name="Helmick R.A."/>
                <person name="Fletcher A.E."/>
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            <dbReference type="DOI" id="10.1128/AAC.49.5.1837-1843.2005"/>
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        <scope>ACTIVITY REGULATION</scope>
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        <scope>INDUCTION</scope>
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                <person name="Hromatka B.S."/>
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        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
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        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pone.0052850"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="5 9 11 13 15 16">Nitric oxide dioxygenase involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Plays a role in virulence since nitric oxide is generated by macrophages of the host immune system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text>Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text>Binds 1 heme b group per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Inhibited by imidazoles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 6 7 9 10 11 12 14 15 16">Expression is under the control of the CDA4 transcription factor. Induced by nitric oxide, high-iron conditions, during transition to filamentous growth, by contact with host macrophages, and during oral infection. Expression is repressed by HAP43 and CWT1.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="16">Leads to increased susceptibility to neutrophils.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711046.1">
        <property type="nucleotide sequence ID" value="XM_705954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MV9"/>
    <dbReference type="SMR" id="Q59MV9"/>
    <dbReference type="BioGRID" id="1230425">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59MV9">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MV9"/>
    <dbReference type="EnsemblFungi" id="CR_07790C_A-T">
        <property type="protein sequence ID" value="CR_07790C_A-T-p1"/>
        <property type="gene ID" value="CR_07790C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647353"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07790CA"/>
    <dbReference type="CGD" id="CAL0000179202">
        <property type="gene designation" value="YHB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07790C_A"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="InParanoid" id="Q59MV9"/>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="PHI-base" id="PHI:500"/>
    <dbReference type="PRO" id="PR:Q59MV9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd19754">
        <property type="entry name" value="FHb_fungal-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000076">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0216">Detoxification</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000422070" description="Flavohemoprotein">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Reductase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Involved in heme-bound ligand stabilization and O-O bond activation" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Influences the redox potential of the prosthetic heme and FAD groups" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12388749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15189992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15387822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15470236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="15855504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="16030247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="17645752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="18083829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="18625733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="19897505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="21131439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="15">
        <source>
            <dbReference type="PubMed" id="22952822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="16">
        <source>
            <dbReference type="PubMed" id="23285201"/>
        </source>
    </evidence>
    <sequence length="398" mass="45819" checksum="3E3827CC14DF04BA" modified="2005-04-26" version="1">MTVEYETKQLTPAQIKIILDTVPILEEAGETLTQKFYQRMIGNYDEVKPFFNTTDQKLLRQPKILAFALLNYAKNIEDLTPLTDFVKQIVVKHIGLQVLPEHYPIVGTCLIQTMVELLPPEIANKDFLEAWTIAYGNLAKLLIDLEAAEYAKQPWRWFKDFKVTRIVQECKDVKSVYFTPVDKDLLPLPKPERGQYLCFRWKLPGEEFEISREYSVSEFPKENEYRISVRHVPGGKISGYIHNNLKVGDILKVAPPAGNFVYDPATDKELIFVAGGIGITPLLSMIERALEEGKNVKLLYSNRSAETRAFGNLFKEYKSKFGDKFQAIEYFSEDNNTDDKIVIDKAFNRKLTTDDLDFIAPEHDVYLVGPREFMKDIKEHLGKKNVPVKLEYFGPYDP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PE7</accession>
    <accession>A0A1D8PFG7</accession>
    <accession>Q59PL8</accession>
    <name>BCP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BCP1</name>
        <name type="ordered locus">CAALFM_C112760WA</name>
        <name type="ORF">CaO19.13702</name>
        <name type="ORF">CaO19.6346</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711564.1">
        <property type="nucleotide sequence ID" value="XM_706472.1"/>
    </dbReference>
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        <property type="interactions" value="1035"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PE7"/>
    <dbReference type="EnsemblFungi" id="C1_12760W_A-T">
        <property type="protein sequence ID" value="C1_12760W_A-T-p1"/>
        <property type="gene ID" value="C1_12760W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646817"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112760WA"/>
    <dbReference type="CGD" id="CAL0000174555">
        <property type="gene designation" value="orf19.13702"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
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        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13862">
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    </dbReference>
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        <property type="entry name" value="BCP1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000249698" description="Protein BCP1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q06338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="321" mass="37455" checksum="D04883F37E452B16" modified="2005-04-26" version="1">MGKRRVDEESDSDIDVSSTDSETELESTQQQQQQQEGATTIQETVDVDFDFFDLNPQIDFHATKNFLRQLFGDDNGEFNLSEIADLILRENSVGTSIKTEGMESDPFAILSVINLTNNLNVAVIKQLIEYILNKTKSKTEFNIILKKLLTNQNDTTRDRKFKTGLIISERFINMPVEVIPPMYKMLLQEMEKAEDAHENYEFDYFLIISRVYQLVDPVEREDEDHEKESNRKKKNKNKKKKLANNEPKPIEMDYFHLEDQILESNTQFKGIFEYNNENKQETDSRRVFTEYGIDPKLSLILIDKDNLAKSVIEMEQQFPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PP1</accession>
    <name>Q59PP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C703460WA</name>
        <name evidence="1" type="ordered locus">orf19.8910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711670.1">
        <property type="nucleotide sequence ID" value="XM_706578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PP1"/>
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    <dbReference type="STRING" id="237561.Q59PP1"/>
    <dbReference type="PeptideAtlas" id="Q59PP1"/>
    <dbReference type="GeneID" id="3646712"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703460WA"/>
    <dbReference type="CGD" id="CAL0000184770">
        <property type="gene designation" value="orf19.8910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03460W_A"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="InParanoid" id="Q59PP1"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF3">
        <property type="entry name" value="OS09G0267800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000184770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="69278" checksum="B1F9DC9028469B6E" modified="2005-04-26" version="1">MMPSIDTDIDIFVVLGKLPSDIVGLILDYLPKCMLHELLYFPPIREVVASAILSKMLISNVLQRNTDYSECNCDLLDITPKKLKRAIDQWNIFPKFVVIKDFNLFKAVLDLSPQVLHNAINLYGVFCVKSDADRQKSLEILVNSNVKFSHFALMNFGHVTTLPAVTTSLTLGDTTLASYMVDGLKRLHVSQGFIEERVTSYNFPSSLEDLEIEGPRSPKVILPPNLRKLNIGTISVSIESATGQAGKLEELSLALPHIESFDEIGIVAPNLKILNIEYCGKLINYDGLKKFQNLKELSIKYCNYPIGVFAGNLFPELKKFEYMGTDYDFGIPDFIPTDLFGTTLEFPPNLKYLSIKFASFMRVDLSTLVLPSKLKHLELWGVKLGFGYLHLSENLEYVRIRSPELEFDDNFRIPQKMKYFQVTANYFYFETPDFMYHLPDGLEHLQLVSRKDGDMGQLYNKVQWPKSLKIFRLHYFSFNSRSLAFLKLSKSCLEEIDIRGGHYKRLNADSLPKSVRVLILKKMGIQELCGSFERLNNLNKLLVTHTNLRNQAPIKLPVSSLSLIDLRYCKLDTKSPFVVSIRQEKNKNTCLKVKESDFWGMSDMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Q44</accession>
    <name>Q59Q44_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">RTS1</name>
        <name evidence="4" type="ordered locus">CAALFM_C206420CA</name>
        <name evidence="3" type="ordered locus">orf19.7691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711827.1">
        <property type="nucleotide sequence ID" value="XM_706735.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Q44"/>
    <dbReference type="SMR" id="Q59Q44"/>
    <dbReference type="FunCoup" id="Q59Q44">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Q44"/>
    <dbReference type="GeneID" id="3646557"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206420CA"/>
    <dbReference type="CGD" id="CAL0000194680">
        <property type="gene designation" value="RTS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06420C_A"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_0_1"/>
    <dbReference type="InParanoid" id="Q59Q44"/>
    <dbReference type="OMA" id="QYIDHEF"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine protein phosphatase 2A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="685"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
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        </location>
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            <begin position="87"/>
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        <location>
            <begin position="98"/>
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        </location>
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            <begin position="215"/>
            <end position="232"/>
        </location>
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        <location>
            <begin position="706"/>
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        </location>
    </feature>
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        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
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        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000194680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="850" mass="94688" checksum="DA280C4CE9628409" modified="2005-04-26" version="1">MMKGFKNRLTRNKGQSTNKKTEKKDKEREKEREKPEKRSSSPSSLSLNTSSSSSQSSKNLMTNTSGSLKSNSPSPSRNNSSTSAGSIKSTASNITMTSASSPQGSPSQSSPKIVVNNEEDISGNVFGSPSQPTDNNPSTSSGSTTTGTGTGAASALSPGSSTPLNASANAHTSNVPSISASGPAPSFNLNHPITPTPTSPNSSLGFHNQFEGKATHSQHSAQPHYSQLTPNIASPGKENIDIDLIVTPKRHSSSRFEPTSSDRYQEIVKLPNFDEVLPEEQIQLFIQKIDQCNTMFDFSDPTFDIRGKEIKRITLQELIGFISNNRFTYTDEMYKHVVTMFKKNLFRPIPPPVNPIGDIYDPDEDEPVSELAWPHMQAIYEFFLRFIESPDFQHQVAKQYIDHEFILRILELFDSEDPRERDCLKTTLHRIYGKFLSLRSFIRKSINNVFLQFVYETERFNGIGELLEILGSIINGFALPLKEEHKIFLVRVLIPLHKVKCLSLYHPQLAYCIVQFLEKDPSLTEDVIMGLLRYWPKVNSPKEVMFLNEIEDIFEVMEPNEFIKIQIPLFAQLSKCISSPHFQVSEKVLCYWSNEYFLTLITENAEVVLPIIFASLYELTNATQAGIENGIMNQKLAQFPNATTDANGNLIDNGLVLQDLQQGIAPSMNNPSHPHYNIFQVHASINNNNNNNGNNNNNNDGSINNPDSMNIHTDSNGNEMSDEEYYDSFTGMGGGNGGPGGTNPNNPLGDDFGGAFDDGTGGLLQHNSATSNWNRSIHSLAYGALKVFMDHNPILYDHCTVLYHQSLAEQKQREANRKEGWKRVEELVRQIKNKKNLESQQPQHPASGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SC9</accession>
    <name>Q59SC9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C208920WA</name>
        <name evidence="6" type="ordered locus">orf19.7847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712599.1">
        <property type="nucleotide sequence ID" value="XM_707506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SC9"/>
    <dbReference type="SMR" id="Q59SC9"/>
    <dbReference type="FunCoup" id="Q59SC9">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SC9"/>
    <dbReference type="GeneID" id="3645797"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208920WA"/>
    <dbReference type="CGD" id="CAL0000187870">
        <property type="gene designation" value="orf19.7847"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08920W_A"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468501_0_0_1"/>
    <dbReference type="InParanoid" id="Q59SC9"/>
    <dbReference type="OMA" id="LHLCFQY"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
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        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
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        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000187870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="582" mass="64030" checksum="4507EFB055F78195" modified="2005-04-26" version="1">MLEPSQRIRNAIIEGNLPIVKRILSRFSELWLNIDPKNQGWSNLHYASYYGHYLICIHLISYINKTLGSLEQHYTKLDLVAFDDTTVLHLCMEKKHAQTLHYLLQEFPGKIWLNSLGGSSRQTPLHYSCIHDFKEGTKLLLEFGAQWSIQDAHGDTCLHLCFQFGSVGCLYELLKYIIIHSKTKEDASEKIEELENVKNKQNWVAKDYSSSFDLITQYEEMKRDLLSQDYTGAVSEIKFSAESTTSPNPEVASIDTLGNKVLASPIVSMTSQQSVANNDKNFEGRQHSQSLPSAFKAQPQPQPLVRQRSNTTYVYKPPAALTIATEGLTGRSPSSNSSPLSPMTPQPTTSNRAPSLKSVTISPSVRTNGTTNYNAGTDDEPISPQSAISTTSSFNASPNYKLGSRKKSFSFSKSVPLPSINSENVLWPSVNEEGVTESPPQQISPIKRSAADYKLRKNSSASSIAAKLAFNSSHSSPNHNEILRKRAASKSNSVHSNSLNSASSVSSSISSGSVSTIDTEIVRKARSSGTLPSSPSHKNNSHNNGIKIPITLNNNSVTSLNSNGSDNLKKYSVHSISFSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SS1</accession>
    <name>Q59SS1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ccc1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">CCC1</name>
        <name evidence="8" type="ordered locus">CAALFM_C303710WA</name>
        <name evidence="7" type="ordered locus">orf19.14210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712749.1">
        <property type="nucleotide sequence ID" value="XM_707656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SS1"/>
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                <person name="Dungan J."/>
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    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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    </evidence>
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        <source>
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    <sequence length="446" mass="49537" checksum="F86A832B0035E47D" modified="2005-04-26" version="1">MGYSLSALVSTNPSALSYFDISFLTFEAVLEVVIICCAGFVAAKTGLLTTQGQKTLSSLNVDLFTPCLIFTKLAPNLSFSKLVEIIIIPIFYAVSTGVSYWSSRIVSKALSLNSPETDFVTAMAVFGNSNSLPVSLVLTLSYTLPDLLWDDVEDDNTDKVAGRGILYLLIFQQLGQILRWSWGFNTLLRKRSQLELNTYHTKHGKIVLHENCRLIDGEDEQFLYMDSNQQQEEQQTETTREISLSEDEDNINSKPLTAYICQLPGVKQFLSFMNPPLYAMLVAIIVASIPYLKNLIFDSEQNSIVYNTFTKAITTLGGVSIPLILIVLGSNLYLSNDIPPPSKHYNRILFGSLLSRMILPSAVLLPIIALCVKYIKASILDDPIFLIVAFILTVSPPAIQLSQITQLNNVYQKEMSGVLFWGYVVLVVPTTIAIVVCSLKVLEWAK</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="CinA_C"/>
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        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000176170"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26097.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    <sequence length="189" mass="20443" checksum="305B000794561DD8" modified="2005-04-26" version="1">MAFPPEDIAQIVLEIATILRTRNQTLAVSEAACGGLISAYLVSVPGASDFYIGGKLLYSMKTRLKLSGWSENEINNYMGPSEQVALKLARTTKYELGSTFVLSETGFAGPSTALHLKKDEETKDNNNNESGVVDADGVGTVYIGLSGPNGDASTSYHTGKTDRNVNMSEFAKLGLQFLLEQLQQQQQQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XA7</accession>
    <accession>A0A1D8PN06</accession>
    <name>HYR3_CANAL</name>
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        <recommendedName>
            <fullName>Hyphally regulated cell wall protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Adhesin-like protein HYR3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HYR3</name>
        <name type="synonym">IFF2</name>
        <name type="ordered locus">CAALFM_C500730WA</name>
        <name type="ORF">CaO19.575</name>
        <name type="ORF">CaO19.8206</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Saccharomycotina</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="1451" last="1469">
            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
            <authorList>
                <person name="Lan C.Y."/>
                <person name="Rodarte G."/>
                <person name="Murillo L.A."/>
                <person name="Jones T."/>
                <person name="Davis R.W."/>
                <person name="Dungan J."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="15387822"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Infect. Immun." volume="75" first="2922" last="2928">
            <title>Candida albicans Iff11, a secreted protein required for cell wall structure and virulence.</title>
            <authorList>
                <person name="Bates S."/>
                <person name="de la Rosa J.M."/>
                <person name="MacCallum D.M."/>
                <person name="Brown A.J."/>
                <person name="Gow N.A."/>
                <person name="Odds F.C."/>
            </authorList>
            <dbReference type="PubMed" id="17371861"/>
            <dbReference type="DOI" id="10.1128/IAI.00102-07"/>
        </citation>
        <scope>IDENTIFICATION IN THE HYR1/IFF FAMILY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1317" last="1330">
            <title>Unexpected role for a serine/threonine-rich domain in the Candida albicans Iff protein family.</title>
            <authorList>
                <person name="Boisrame A."/>
                <person name="Cornu A."/>
                <person name="Da Costa G."/>
                <person name="Richard M.L."/>
            </authorList>
            <dbReference type="PubMed" id="21841123"/>
            <dbReference type="DOI" id="10.1128/EC.05044-11"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <topology evidence="6">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Induced in high iron conditions.</text>
    </comment>
    <comment type="PTM">
        <text>The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HYR1/IFF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709110.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XA7"/>
    <dbReference type="STRING" id="237561.Q59XA7"/>
    <dbReference type="GlyCosmos" id="Q59XA7">
        <property type="glycosylation" value="48 sites, No reported glycans"/>
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        <property type="protein sequence ID" value="C5_00730W_A-T-p1"/>
        <property type="gene ID" value="C5_00730W_A"/>
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    <dbReference type="GeneID" id="3644119"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500730WA"/>
    <dbReference type="CGD" id="CAL0000179043">
        <property type="gene designation" value="HYR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00730W_A"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006199_0_0_1"/>
    <dbReference type="InParanoid" id="Q59XA7"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="PRO" id="PR:Q59XA7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031573">
        <property type="entry name" value="Cell_wall_rpt"/>
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    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903:SF1">
        <property type="entry name" value="HYPHALLY REGULATED CELL WALL PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15789">
        <property type="entry name" value="Hyr1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424754" description="Hyphally regulated cell wall protein 3">
        <location>
            <begin position="21"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424755" description="Removed in mature form" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="883"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="883"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1217"/>
        </location>
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    <feature type="lipid moiety-binding region" description="GPI-anchor amidated asparagine" evidence="2">
        <location>
            <position position="1225"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="891"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="940"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="944"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="952"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="966"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="970"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="974"/>
        </location>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="992"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="996"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1000"/>
        </location>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1010"/>
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    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1014"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1018"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="1026"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="1032"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1046"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="1050"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1058"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="1062"/>
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    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1072"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1076"/>
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    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1080"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1086"/>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1090"/>
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    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1094"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1098"/>
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    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1114"/>
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            <position position="1122"/>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="1128"/>
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            <position position="1136"/>
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            <position position="1140"/>
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            <position position="1150"/>
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            <position position="1154"/>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="1158"/>
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            <position position="1172"/>
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            <position position="1180"/>
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            <position position="1225"/>
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    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
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            <dbReference type="PubMed" id="15387822"/>
        </source>
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    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21841123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1249" mass="123069" checksum="AA0FB5AD92818CFA" modified="2005-04-26" version="1" precursor="true">MHLFKRIALTLWLIISSTLAVVITEDRVDRGTISVNLGEVTVNSGASWSIINNAVTAFAGKINVQSGGGLYISSTSPLLALQVTLTSLLDSITNDGVISLDSRASLTASNYNLIGLSFTNNGEMYLAASGVLPSTMDLTAASWTNNGLIVAYQNQRSSGVLNLGTPLGAITNNGQICLYNQVYQQQTRIEGSGCITANKNSAIYISNAVLPVATTQNFYLQDSKSSMIVQAVSSTQTFNVYGFGNGNKIGITLPAVGIPPNPAYSYDVDTGILTVRAGLLSQKFNIGLGYYSLFFSVVTDNGAGLPSTILGSISYSGPVPSRNLPASCKIACKPVPTAPGTNPTEYTTTITTTNSAGNPLTETGVVDISTDSNGSWFTTTSIFPTTSQSSSSETVASSSQPDSSSTEPSAFPSSTGDSSAEPSITSDYSSSELSVVPSSASESASESSAEPSSASESASESGSESVASETSASESASEQSSTSESVSSEFASSDSSSEPSSASESSVESSSASEFVVPSSATETSVSESASESSAEPSSASESVASESAVSETSASESAAPSSASETSVSESAASSSASESFASESSVESSAVPSSASEFSTSESVASETPASETPASETPASESASEQSSTSESSAEISSASESSAEPSSAKSAISESASEFSAAPSSASQSSASQSSTNESSSQQSSAESSSTGTSSVSASAATSEYTATWTTTNSDGSVSTESGIISQSGSSFTTITTFVPDATSEYTTTWTTTNSDGSVSTESGIVSQSGSSFTTITTFAPDATSEYTTTWTTTNSDGSVSTESGVVSQSGTSLTTITTFAPDVTSEYTTTWTTTNSDGSVSTESGIVSQSGSSFTTITTFEPPVVCKRDDVNCGSSIGLSTPYYGNSSQPLSSTKMTDTSATQTVDSSLSSITDATTTQSVNSLETPVPTSGSGNGSNNGSDNGSNNGSNNGSNNGSGSGNGSNNGSNNGSGSGNGFNNGSDNGSNNGSGNASNNGSASGSGSDNGSDNGSDNGSDNGSNNGSNTDNGSNSGSDSGNGIDNGSGNGSSDGSDNGTTNGSGSGGESNNGSGNGSDNGSSPDNGSNNGSNNGSNNGSGDGIGTGSNSDTDNGSGNGSNNGSGSVNGSANGSGNGSNNGSNSGSNSDNGSNNSSGNGSSSDLGSVSGTGNGSNEGSSNESGANNGSNNGAGALPAATLSVVPSPSADSGSTSSASAMVIPNTNGSGKLLNGKVLTLSVLSSMVVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A283</accession>
    <name>Q5A283_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Bifunctional AAA family ATPase chaperone/translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_CR05970CA</name>
        <name evidence="14" type="ordered locus">orf19.8089</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715892.1">
        <property type="nucleotide sequence ID" value="XM_710799.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A283"/>
    <dbReference type="SMR" id="Q5A283"/>
    <dbReference type="FunCoup" id="Q5A283">
        <property type="interactions" value="1156"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A283"/>
    <dbReference type="GeneID" id="3642502"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05970CA"/>
    <dbReference type="CGD" id="CAL0000200745">
        <property type="gene designation" value="orf19.8089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05970C_A"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </evidence>
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    <sequence length="444" mass="50120" checksum="9381AAE31E39AA59" modified="2005-04-26" version="1">MAQTPQSIDFEKIKESSDGTLKGMLTQGFNEIVVNNPYFAAGGGLMLLGTGLALARSGVVKGSGFIYRQLLVDLEIPSKDKSYLWFLEWMSQYKHRTSRHLSVETNVITHDNGAITTNFSLVPGPGKHLIRYKGAYMLVNRERSGKLLDMTSGTPFETVTLTTLYRDRKLFNDLLSEAKSLALKAREGKTVIFTSWGPEWRPFGQPRSKRLLGSVILDEGIAENIVNDVKDFLTSGEWYHKRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNHIPNRSILLLEDVDAAFNKREQTNDQGFNNGVTFSGLLNALDGVASAEECITFMTTNHPEKLDPALLRPGRVDYKVMIDNATEHQVKRMFLRFYENEEELCEKFLAKYRKLNMQHVSTAQLQGLFVYNKRDPEAAIAMIETLQNPNTVF</sequence>
</entry>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="344" mass="40197" checksum="8ED2CCC8D04401BC" modified="2005-04-26" version="1">MSQQEKSTFRSYTKEELHDLLTKLELPVKSKTTKKAMVEILDDFVEKHPEELDNIEKILQTEEDEDDDDDEEDEDIVEVVKIDGEEDEDEDDEEEEEEEAEDDEEEEEDDKDYEAPPPLNLKEWVVDPIIAQSETFIEKFYEFTDNVGITYLNQSEKLRDQLSSTVTLNYLQIGVELLIFIYTFIRVVPLNENNLIHQIFHDNIPYLSIITWPSLEISSIFQYKSIITFIIWSITSIIIPSIVSYFINFTSRVIEIEDDEYLFRVYSFDPFIFALSKILTFYFIGQFALIEFATCECFISAIFNKTLLNIGLYQSFATNNLGTLPYVLGGVNVLIALYAQFEEY</sequence>
</entry>
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    <accession>Q5A4Z5</accession>
    <name>Q5A4Z5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C500390CA</name>
        <name evidence="2" type="ordered locus">orf19.8566</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716790.1">
        <property type="nucleotide sequence ID" value="XM_711697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4Z5"/>
    <dbReference type="STRING" id="237561.Q5A4Z5"/>
    <dbReference type="GeneID" id="3641552"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500390CA"/>
    <dbReference type="CGD" id="CAL0000199693">
        <property type="gene designation" value="orf19.8566"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00390C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQJ7">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618783_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A4Z5"/>
    <dbReference type="OMA" id="CDCKNET"/>
    <dbReference type="OrthoDB" id="4024210at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="162" mass="18284" checksum="54554BB08920F2E7" modified="2005-04-26" version="1">MALRNYLYAKHDHDTSIDIKINKDNSLMSNITEKVSPSSPSPSDPSDSQKQQRSPMQIQQSRRRIIRIVHKKSSNKLKLNPSVNSIEKLTNNIENVHIEKKKKENCLNDCNLCDCKNETNDNEKDNPLIQVEVDNRVNSGGVGDGGHNEIVSNNEIDFTSSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2025-04-09" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A651</accession>
    <accession>A0A1D8PM25</accession>
    <name>CAR10_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Secreted aspartic protease 10</fullName>
            <shortName evidence="10">ACP 10</shortName>
            <shortName evidence="10">Aspartate protease 10</shortName>
            <ecNumber evidence="8">3.4.23.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Candidapepsin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SAP10</name>
        <name type="synonym">YPS3</name>
        <name type="ordered locus">CAALFM_C404470WA</name>
        <name type="ORF">CaO19.11320</name>
        <name type="ORF">CaO19.3839</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="J. Biol. Chem." volume="281" first="688" last="694">
            <title>Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.</title>
            <authorList>
                <person name="Albrecht A."/>
                <person name="Felk A."/>
                <person name="Pichova I."/>
                <person name="Naglik J.R."/>
                <person name="Schaller M."/>
                <person name="de Groot P."/>
                <person name="Maccallum D."/>
                <person name="Odds F.C."/>
                <person name="Schafer W."/>
                <person name="Klis F."/>
                <person name="Monod M."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="16269404"/>
            <dbReference type="DOI" id="10.1074/jbc.M509297200"/>
        </citation>
        <scope>GLYCOSYLATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="J. Biochem." volume="150" first="431" last="438">
            <title>Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.</title>
            <authorList>
                <person name="Aoki W."/>
                <person name="Kitahara N."/>
                <person name="Miura N."/>
                <person name="Morisaka H."/>
                <person name="Yamamoto Y."/>
                <person name="Kuroda K."/>
                <person name="Ueda M."/>
            </authorList>
            <dbReference type="PubMed" id="21646240"/>
            <dbReference type="DOI" id="10.1093/jb/mvr073"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:16269404, PubMed:21646240). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Required for cell surface integrity and cell separation during budding (PubMed:16269404, PubMed:21646240).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="8">Optimum pH is 6.0.</text>
        </phDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="8"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717243.1">
        <property type="nucleotide sequence ID" value="XM_712150.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A651"/>
    <dbReference type="SMR" id="Q5A651"/>
    <dbReference type="STRING" id="237561.Q5A651"/>
    <dbReference type="MEROPS" id="A01.085"/>
    <dbReference type="GlyCosmos" id="Q5A651">
        <property type="glycosylation" value="8 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_04470W_A-T">
        <property type="protein sequence ID" value="C4_04470W_A-T-p1"/>
        <property type="gene ID" value="C4_04470W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641126"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404470WA"/>
    <dbReference type="CGD" id="CAL0000201140">
        <property type="gene designation" value="SAP10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04470W_A"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="Q5A651"/>
    <dbReference type="OMA" id="QCYLAIM"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PRO" id="PR:Q5A651"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424306" description="Secreted aspartic protease 10">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424307" description="Removed in mature form" evidence="3">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="3">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0CY27"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0CY29"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="16269404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="21646240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="16269404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <sequence length="453" mass="49333" checksum="D26DDFF460BCFC37" modified="2005-04-26" version="1" precursor="true">MDLVIMNFVFLLYLTSVVKCSIKLDFNKVSTPSKYTKRDALPMPLINDKILYTTELEIGSNKDKVSVSIDTGSYDLWVMSNDAVCYKVSEFQTEGAPQLPDIFNDIDQDYSCTFNGTYNSKSSKTFKNTSEDFSIGYVDGSAAQGVWGYDSVQFGQYGVTGLKIGIANRSSVSDGILGIGIANGYDNFPVLLQKQGLINKIAYSVYLNSSNSTTGTILFGAIDHAKYKGALSTVPVDSKSQLSVNVTNLKTKNGNVASGGHSILLDTGSTFSIFPDEWIDALGHSLNATYDEDESVYEIECDGYDEHFFGFSIGDSDFSVPIQDLKTEKDGQCYLAIMSNSVIGGGGILFGDDILRQIYLVYDLQDMTISVAPVVYTEDEDIEEILNPNEDQNEVPTSTSFTQSASSSGSQPSSTISGENMDKNTTSSSSGNCQTRSWIAILSALFLVYIHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6L4</accession>
    <name>Q5A6L4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_CR04490CA</name>
        <name evidence="9" type="ordered locus">orf19.8173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717403.1">
        <property type="nucleotide sequence ID" value="XM_712310.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6L4"/>
    <dbReference type="SMR" id="Q5A6L4"/>
    <dbReference type="STRING" id="237561.Q5A6L4"/>
    <dbReference type="ESTHER" id="canal-q5a6l4">
        <property type="family name" value="Palmitoyl-protein_thioesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="3641013"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04490CA"/>
    <dbReference type="CGD" id="CAL0000191043">
        <property type="gene designation" value="orf19.8173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04490C_A"/>
    <dbReference type="eggNOG" id="KOG2541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050129_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A6L4"/>
    <dbReference type="OMA" id="KFVMVMF"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000191043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="316" mass="36417" checksum="CF70745C5CD5E772" modified="2005-04-26" version="1">MLLSNLFNVQQTILSLIPATNFDVSTSFPEPVLSTTDTYRPVVIWHGLGDNYNTSGIHKVHEILDSMYPGIFVYAIRLDDNPSSDEQKSFFGDANKQIDEVCQQLRNITELSHGFDSIGFSQGGVFMRGLIERCPLEVNNLITFGSPHLGVSELPLCKDRFDWLCKRRNALLKKQVWHDSVQKRVIPAQYFRDPANIDQYLEHSNYLADINNERDEKNATYKENFSKLNKLVLVSFTEDTTLVPKESSQFHDFDPEHKRSIPFLYTELYKNDYIGLKTLYEKNSVDFLSIEAEHMHIDEDFIKNIAQEYLGGKLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A868</accession>
    <name>Q5A868_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphopantothenoylcysteine decarboxylase complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CAB3</name>
        <name evidence="6" type="ordered locus">CAALFM_CR00980CA</name>
        <name evidence="5" type="ordered locus">orf19.10770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717950.1">
        <property type="nucleotide sequence ID" value="XM_712857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A868"/>
    <dbReference type="SMR" id="Q5A868"/>
    <dbReference type="STRING" id="237561.Q5A868"/>
    <dbReference type="GeneID" id="3640426"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00980CA"/>
    <dbReference type="CGD" id="CAL0000174890">
        <property type="gene designation" value="CAB3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00980C_A"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014402_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A868"/>
    <dbReference type="OMA" id="HILLGCT"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="BRENDA" id="4.1.1.36">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="364"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000174890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="731" mass="80391" checksum="B522A5E3BB7F27E0" modified="2005-04-26" version="1">MSQDSSDQRPPQSESLQTISSDNTTTTTKHTEKRISETKLENGNHCLSDIARGHNPSSIKGNGSTKNSVASGIKVNTNSASGIAPPTKILTNSSKEVTSPVLQNSNTPILGSANTSGTNIPVRNQSVSFSDIDNQERSRRFTISAKPSTVNVPQEVQLPQSSRHPSSAAPSRQSSVKTKRVTSPVNSGEGNVYNDVLTFMTNHSHGKLNTALPSNVHVGAIRSDNSSPITPEGAIDPGFNFDYNKNSLNRIASPSPPPFSRSNGSSSTSSPKRSKTPNTQEPVPPQEPITTTEKLISEPSSQSAIKPLPSSQIVQPIKITGTGSANSSRRGSLKKSNKTIVSSPIGPPVPFQQFLSKQDDGKFHILLACTGSVATIKVPLIIDKLFQIFTTSKISIQLVLTKSSSHFLRGCKIHEDVKIWRDEDEWANFSDAYNSASTTVCSTMGNDGLNVVNKKPKNPFEKLILHNELRKWADIMLIAPLSANTLAKIANGIADNLLTSIVRSWCPSTFQQVKKPIIVAPAMNTFMYTHPITAKQLNIISSPDFGIEVLKPVEKILVCGDIGMGGMREWAEIVDVLRRRVHSIKAEQKKLLDEEQRLNEEEEEEEEDDDNDEEGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDVEEDNEEEDVDDTNKRKLVRNNTSNSEELPKKDDDEMIFEITDQEQSEQDDEGEIVTNESRTISPVPSHRQQKIKIPKETQNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8L5</accession>
    <name>Q5A8L5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCR4-NOT core DEDD family RNase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">POP2</name>
        <name evidence="4" type="ordered locus">CAALFM_C603650CA</name>
        <name evidence="3" type="ordered locus">orf19.13156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718072.1">
        <property type="nucleotide sequence ID" value="XM_712979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8L5"/>
    <dbReference type="SMR" id="Q5A8L5"/>
    <dbReference type="STRING" id="237561.Q5A8L5"/>
    <dbReference type="GeneID" id="3640301"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603650CA"/>
    <dbReference type="CGD" id="CAL0000180752">
        <property type="gene designation" value="POP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03650C_A"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027974_3_2_1"/>
    <dbReference type="InParanoid" id="Q5A8L5"/>
    <dbReference type="OMA" id="WQFNFLY"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:P-body"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:phospholipid homeostasis"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000107">
        <property type="entry name" value="Poly(A) ribonuclease POP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000180752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="492" mass="55471" checksum="33B1F5A87AB726F0" modified="2005-04-26" version="1">MNVNPHLQYLQQQQQQQQQQQQQQQQSQPSQSNQSQSNQSPQFSQLQLQQLQRQQLLNQHLQQQQSQSQSSQVPPQLTQQSMGTPTSTNPLLAVLNGGANSNATSTGNGSLSSNPVLQQLQLQQLQQQVQLQQLQAQQQQQQQQQQQQQAIPIIKEVWSSNLEHEFQALRTFINDKTSKVFIAIHQEIPGIVARPVGTFKSSSDYHFQTLRANSDLLNLIQLSLCVIKISKNETISTPVIWQFNFLYDLTKEMYNEEHLAMLAQTSQINFQLLSTHGIPHFEFAELMIESGLILDDNINWVSFHAGYDLGFFVSLLSNDDLPVDEPDFYWWCAKYFPNFYDLKYIGNQILNKSTTNGAGGTNSNTLDEKTNKPSIEYLAEELHLLPISPAIRQHFTNSTFHSQQLTSTLHAYLSMECFKELLRRSNMTLLSSFKGTIWGLGTFSGGTSINNTNNNGVTEDEIVASRINGISTPSTPVGIISKSGMVHFGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A9E7</accession>
    <name>Q5A9E7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_CR01350CA</name>
        <name evidence="8" type="ordered locus">orf19.10054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718186.1">
        <property type="nucleotide sequence ID" value="XM_713093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A9E7"/>
    <dbReference type="SMR" id="Q5A9E7"/>
    <dbReference type="FunCoup" id="Q5A9E7">
        <property type="interactions" value="938"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A9E7"/>
    <dbReference type="GeneID" id="3640166"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01350CA"/>
    <dbReference type="CGD" id="CAL0000189503">
        <property type="gene designation" value="orf19.10054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01350C_A"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046329_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A9E7"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000189503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="293" mass="33024" checksum="DDB2567A9A58316C" modified="2005-04-26" version="1">MPDPRSLIAEAEKLLKPQSGFFSFLSGSSASMRKEDATDLYIQAANSYRLKKDFNLAGAQFVKAAEIQESLGNHNDTANHLVEAYKCFKGVSPTDAISSLSKAIHIFLTQNGQFRRAANFTMDLAELYESVNDYENASKSYEQAGDYFTTDHAEALANKAFLKCADLYALNGNYKRAVELYDNIIKNSLGNSLSRWSLKDYFFKVVLCVLCMDDVIEAHKRKDQFLQDDPSWGQSREYKLVEGILESIDQGDVEGFSDKVFDFDQFSKLDKLKTQLLLKVKNSVVAKDDDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAS9</accession>
    <name>Q5AAS9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">MRPL19</name>
        <name evidence="12" type="ordered locus">CAALFM_C106790CA</name>
        <name evidence="11" type="ordered locus">orf19.13611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718820.1">
        <property type="nucleotide sequence ID" value="XM_713727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AAS9"/>
    <dbReference type="SMR" id="Q5AAS9"/>
    <dbReference type="FunCoup" id="Q5AAS9">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AAS9"/>
    <dbReference type="GeneID" id="3639497"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106790CA"/>
    <dbReference type="CGD" id="CAL0000178684">
        <property type="gene designation" value="MRPL19"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06790C_A"/>
    <dbReference type="eggNOG" id="KOG3257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AAS9"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000178684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="143" mass="15124" checksum="0219C84465CC677A" modified="2005-04-26" version="1">MSAKGALVKLVVEAGKAAPAPPVGPALGSKGVKAIDFCKEFNARTAIYNQGVPIPVIIQVKPDRTFTFEMKSPPTSWLLMKAAGVEKGSGKALKEPVGEVSLKHIWEIAKIKKTDDRHKSVDLKAIVGSVISTAKVVGIKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAT6</accession>
    <name>Q5AAT6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C106860WA</name>
        <name evidence="10" type="ordered locus">orf19.13604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718813.1">
        <property type="nucleotide sequence ID" value="XM_713720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AAT6"/>
    <dbReference type="FunCoup" id="Q5AAT6">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AAT6"/>
    <dbReference type="GeneID" id="3639530"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106860WA"/>
    <dbReference type="CGD" id="CAL0000199366">
        <property type="gene designation" value="orf19.13604"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06860W_A"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_3_1"/>
    <dbReference type="InParanoid" id="Q5AAT6"/>
    <dbReference type="OMA" id="YLCQIIC"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000199366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="497" mass="55830" checksum="DCABC48863BD1C78" modified="2005-04-26" version="1">MDGVSLLNQYLPSWTPTSLPTSTSISTINPTNTAGLALTLLELQNAIQTETNTISLYFLSRAARGVAASYTIISGQQYLATATATQDFPEVTSAMVNATLSLKQLEWKANLYAINLSVPFNAFFAAMFGVTLICLLGIGFSTKTKYFTICLACGTILEVIGYVARTLAHYSWSDPNLFLCQIVSLTVAPAFIMAGVYYLLSQMIIIHGEQYAILKPIMVSIIFIFCDVVSLFVQASGGAAAAVSLRSFKDTELGTYIMVGGIGFQVVSMTLFLYFLFDFVYRSFFTANSNIKYSFSTYCSLLFNTKKGRLLRQDLEPFYDVGYKHIRQRSLFNYMPLVIIISVGFIYIRCIYRVIELSEGWRGYLITHEEYIFALDALMVLLTCITYVFFHPGLVFGKQMTAQISVSANKSESAADHESHCGNSRMYNYSKNHSNSPQSSHDEKFIMDQRQKYYNPYFLPTKFSQYNSHSCPSSETYTYSSYNSKLETKSESSWQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB97</accession>
    <name>Q5AB97_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hmx1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">HMX1</name>
        <name evidence="7" type="ordered locus">CAALFM_C100350CA</name>
        <name evidence="6" type="ordered locus">orf19.13494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719035.1">
        <property type="nucleotide sequence ID" value="XM_713942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AB97"/>
    <dbReference type="SMR" id="Q5AB97"/>
    <dbReference type="FunCoup" id="Q5AB97">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AB97"/>
    <dbReference type="GeneID" id="3639294"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100350CA"/>
    <dbReference type="CGD" id="CAL0000188588">
        <property type="gene designation" value="HMX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00350C_A"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049906_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AB97"/>
    <dbReference type="OMA" id="FAFAFQM"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034465">
        <property type="term" value="P:response to carbon monoxide"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000188588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW25733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="291" mass="33972" checksum="9462A7A7BA47BF9D" modified="2005-04-26" version="1">MQYKSSGATSKLSQVEIIPAKTDVGALANRINLETRSLHDRADKTVTLKFALALRNYKVYRQGLQAFYHVFASIEKALYRQLEKKDEWSEMLEQVWKPEIARAGKAEQDLLFFYDDNKEKFIKPIMPAQIEFCKHILEVTEEKPYLLFAYLHVMYLALFAGGRIMRSSVLKATGMYPQRDGLSHDDVVRMGTNFFTFDVPDEDLLRLTYKRDYELVTRNGLTEEQKLEIIEESKYIFEHDVKCVAELEKHNMDKLSGTWTYFLVTRGYYAALVLFSLLALIYLRRVVNKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABD5</accession>
    <name>Q5ABD5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C100700WA</name>
        <name evidence="10" type="ordered locus">orf19.13456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718997.1">
        <property type="nucleotide sequence ID" value="XM_713904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABD5"/>
    <dbReference type="SMR" id="Q5ABD5"/>
    <dbReference type="STRING" id="237561.Q5ABD5"/>
    <dbReference type="GeneID" id="3639330"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100700WA"/>
    <dbReference type="CGD" id="CAL0000176204">
        <property type="gene designation" value="orf19.13456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00700W_A"/>
    <dbReference type="eggNOG" id="KOG3426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111660_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ABD5"/>
    <dbReference type="OMA" id="FWKQTTH"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000176204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW25768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="121" mass="14674" checksum="1D9133082E9E29E7" modified="2005-04-26" version="1">MTLATQFAETTRYSVSNTELKRRVLHLYRKYIRNANEFADLYELDMPVSNIKTKIRQEFERQRFGNDLSVNNVLLMKGQMEFQELINFWKQQCHVMRYFDEQNSYNVVDKNDFVKNFLRGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD78</accession>
    <accession>A0A1D8PGD3</accession>
    <name>DCW1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mannan endo-1,6-alpha-mannosidase DCW1</fullName>
            <ecNumber>3.2.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Defective cell wall 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Endo-alpha-1-&gt;6-D-mannanase DCW1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GPI-anchored protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DCW1</name>
        <name type="synonym">PGA51</name>
        <name type="ordered locus">CAALFM_C201360CA</name>
        <name type="ORF">CaO19.1989</name>
        <name type="ORF">CaO19.9540</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Eukaryot. Cell" volume="2" first="746" last="755">
            <title>Roles of Candida albicans Dfg5p and Dcw1p cell surface proteins in growth and hypha formation.</title>
            <authorList>
                <person name="Spreghini E."/>
                <person name="Davis D.A."/>
                <person name="Subaran R."/>
                <person name="Kim M."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="12912894"/>
            <dbReference type="DOI" id="10.1128/EC.2.4.746-755.2003"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Mol. Biol. Cell" volume="15" first="4490" last="4499">
            <title>Transcription profiling of cyclic AMP signaling in Candida albicans.</title>
            <authorList>
                <person name="Harcus D."/>
                <person name="Nantel A."/>
                <person name="Marcil A."/>
                <person name="Rigby T."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="15269278"/>
            <dbReference type="DOI" id="10.1091/mbc.E04-02-0144"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable mannosidase required for normal synthesis of the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Induced by HAP43 and up-regulated in absence of CYR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719439.1">
        <property type="nucleotide sequence ID" value="XM_714346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD78"/>
    <dbReference type="SMR" id="Q5AD78"/>
    <dbReference type="FunCoup" id="Q5AD78">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AD78"/>
    <dbReference type="GlyCosmos" id="Q5AD78">
        <property type="glycosylation" value="10 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C2_01360C_A-T">
        <property type="protein sequence ID" value="C2_01360C_A-T-p1"/>
        <property type="gene ID" value="C2_01360C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638842"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201360CA"/>
    <dbReference type="CGD" id="CAL0000197643">
        <property type="gene designation" value="DCW1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01360C_A"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AD78"/>
    <dbReference type="OMA" id="WAPHTYD"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="PRO" id="PR:Q5AD78"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010570">
        <property type="term" value="P:regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424805" description="Mannan endo-1,6-alpha-mannosidase DCW1">
        <location>
            <begin position="19"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424806" description="Removed in mature form" evidence="2">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="2">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12912894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15269278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="452" mass="50348" checksum="12A17AC5718B65B0" modified="2005-04-26" version="1" precursor="true">MKFSIYLIISLFSSFSHAIWLDTNNETTIREDCNIIAKGLLDYYEGTKYGGVIGMFSWPYYWWEAGGAWGSLIDYTFYFDNDTLVPLITDALLYQTGDDDNYIPLNQSTTEGNDDQAFWGIAVMAAAERNFTNPKDPTKAWLTLAQAVFNTMQARWDTETCNGGLRWQIFQWNSGYDYKNSVSNGALFHLAARLARYTGNDSYVVWAERVWDWMYGVGLLTEQNWWFVYDGVKIANNCSNITKYQWSYNQGLMLAGCAYLYNYTEEEKWYNYTIKLLESAQVFFKNISGSMVMYEAACQPSNSCNNDQRSFKAYFSRFLGLTSVLVPQTEPVITKWLVDSANGAAGSCSGGSDGVTCGLSWTDWSQGWDGKWGLGEQMSALEVMQNLMVHKRPAPYTADTGGSSIGNPAAGYGKLTSDATPLSIDGGDKAGAGIITAIIGASLVGSCVWLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEG1</accession>
    <name>Q5AEG1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional coactivator HFI1/ADA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C303100CA</name>
        <name evidence="6" type="ordered locus">orf19.7939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AOW28341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C303100CA"/>
    <dbReference type="CGD" id="CAL0000198062">
        <property type="gene designation" value="orf19.7939"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03100C_A"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_033254_0_0_1"/>
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    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="382"/>
            <end position="469"/>
        </location>
    </feature>
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            <end position="391"/>
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        <location>
            <begin position="414"/>
            <end position="423"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000198062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54237" checksum="6184DBF8D3F52E1B" modified="2005-04-26" version="1">MTSQIADGSSTTTINPLKNGLAALKPTHQAHGTSTTTHLTNGSPKKIKSYKRLELERLIREFQNKLGKNWEKYHETLSLFLIGKLSRAELISTITPILKGKNLLKYHNKLLLLNFANSLKDNSSDLSTEFAGFWNKKAGKVTKNKNTQFERFKSVIMGLPVKERKRIIDISRDSGKKGKIATDIILTRHAILPKIPMIQDKEQQQLQVNNLVQWQQDVLNGINTPIATENYEIPDYDNLSRMMLMIMREHGLTGGLNPGVMEVMLLGLESHLKNIVETAIDVAKYRKNKYTNDNYIPYIKPNEDAQNISNENALPSSKDITLCIEDLHDTLEMYPHLVESEGPKLRLSNVMLENDDMINDDLNYYLPPKSIEYLAKERQAATTNDASTGTTKPGNNKGSSAGGSSAGATTNSPVVNKTDSTAAVSEKTDTNQPLQTPTATQTPVQTSAQAPASAPAQTPAPVSTPILRPDAHIGTTDELKWVLHDLVSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEL8</accession>
    <name>Q5AEL8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">SLC1</name>
        <name evidence="9" type="ordered locus">CAALFM_C302600CA</name>
        <name evidence="8" type="ordered locus">orf19.7881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719949.1">
        <property type="nucleotide sequence ID" value="XM_714856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEL8"/>
    <dbReference type="SMR" id="Q5AEL8"/>
    <dbReference type="FunCoup" id="Q5AEL8">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AEL8"/>
    <dbReference type="GeneID" id="3638324"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302600CA"/>
    <dbReference type="CGD" id="CAL0000193373">
        <property type="gene designation" value="SLC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02600C_A"/>
    <dbReference type="eggNOG" id="KOG2848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="InParanoid" id="Q5AEL8"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="80"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000193373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="293" mass="32220" checksum="A870A0D147F2BA06" modified="2005-04-26" version="1">MSAVSSFFTKLKFYLKSGLYGTLVAGCAIYGVLASIILRIVNKAEYAQYAVAKACYYVVSLFLGLKINIKNEKYLQNLPAIVVANHQSALDIYVLGKVFQPGYTVTSKKSLKYVPFLGWFMALSGTFFLDRSKSASAKKVLDGALTGLKNQGKALFIFPEGTRSATEDLTMLPFKKGAFHLARQAGIPIIPVVVSNTSTIFNSKRKIFNTGEINIEVLPPVSTSDWETHEDVTNACNNIRDDMIKTLKKLGNSKIPGSKPREDFYPSESEDTSETDVEIINEQTPLKATAVSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2025-04-09" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEM6</accession>
    <accession>A0A1D8PJG6</accession>
    <name>CARP8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Secreted aspartic protease 8</fullName>
            <shortName evidence="16">ACP 8</shortName>
            <shortName evidence="16">Aspartate protease 8</shortName>
            <ecNumber evidence="9 13">3.4.23.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Candidapepsin-8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SAP8</name>
        <name type="ordered locus">CAALFM_C302510CA</name>
        <name type="ORF">CaO19.242</name>
        <name type="ORF">CaO19.7872</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="J. Biochem." volume="150" first="431" last="438">
            <title>Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.</title>
            <authorList>
                <person name="Aoki W."/>
                <person name="Kitahara N."/>
                <person name="Miura N."/>
                <person name="Morisaka H."/>
                <person name="Yamamoto Y."/>
                <person name="Kuroda K."/>
                <person name="Ueda M."/>
            </authorList>
            <dbReference type="PubMed" id="21646240"/>
            <dbReference type="DOI" id="10.1093/jb/mvr073"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Mycopathologia" volume="174" first="11" last="19">
            <title>In vitro Candida albicans biofilm induced proteinase activity and SAP8 expression correlates with in vivo denture stomatitis severity.</title>
            <authorList>
                <person name="Ramage G."/>
                <person name="Coco B."/>
                <person name="Sherry L."/>
                <person name="Bagg J."/>
                <person name="Lappin D.F."/>
            </authorList>
            <dbReference type="PubMed" id="22302440"/>
            <dbReference type="DOI" id="10.1007/s11046-012-9522-2"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1998" name="Microbiology" volume="144" first="2731" last="2737">
            <title>Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans.</title>
            <authorList>
                <person name="Monod M."/>
                <person name="Hube B."/>
                <person name="Hess D."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="9802014"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E46020" last="E46020">
            <title>Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.</title>
            <authorList>
                <person name="Puri S."/>
                <person name="Kumar R."/>
                <person name="Chadha S."/>
                <person name="Tati S."/>
                <person name="Conti H.R."/>
                <person name="Hube B."/>
                <person name="Cullen P.J."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="23139737"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0046020"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="Peptides" volume="48" first="49" last="58">
            <title>Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.</title>
            <authorList>
                <person name="Bochenska O."/>
                <person name="Rapala-Kozik M."/>
                <person name="Wolak N."/>
                <person name="Bras G."/>
                <person name="Kozik A."/>
                <person name="Dubin A."/>
                <person name="Aoki W."/>
                <person name="Ueda M."/>
                <person name="Mak P."/>
            </authorList>
            <dbReference type="PubMed" id="23927842"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2013.07.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2016" name="Acta Biochim. Pol." volume="63" first="403" last="410">
            <title>The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5.</title>
            <authorList>
                <person name="Bochenska O."/>
                <person name="Rapala-Kozik M."/>
                <person name="Wolak N."/>
                <person name="Aoki W."/>
                <person name="Ueda M."/>
                <person name="Kozik A."/>
            </authorList>
            <dbReference type="PubMed" id="27390786"/>
            <dbReference type="DOI" id="10.18388/abp.2016_1318"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="10 11 12">Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:22302440, PubMed:23139737). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (PubMed:22302440, PubMed:23139737). Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein (PubMed:23927842).</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a key role in defense against host by cleaving histatin-5 (Hst 5), a peptide from human saliva that carries out fungicidal activity (PubMed:27390786). The cleavage rate decreases in an order of SAP2 &gt; SAP9 &gt; SAP3 &gt; SAP7 &gt; SAP4 &gt; SAP1 &gt; SAP8 (PubMed:27390786). The hydrolysis of Hst 5 by SAP8 causes production of the DSHAKRHHGY, HHSHRGY and FHEKHHSHRGY peptides (PubMed:27390786).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="9 13">Optimum pH is 2.5 using casein-resorufin as substrate, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5.</text>
        </phDependence>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="10 14">Expressed in greater amounts in the mature biofilms compared to early biofilms during inflammatory disorder of the palatal mucosa among denture wearers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="9 13"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719941.1">
        <property type="nucleotide sequence ID" value="XM_714848.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEM6"/>
    <dbReference type="SMR" id="Q5AEM6"/>
    <dbReference type="STRING" id="237561.Q5AEM6"/>
    <dbReference type="MEROPS" id="A01.066"/>
    <dbReference type="EnsemblFungi" id="C3_02510C_A-T">
        <property type="protein sequence ID" value="C3_02510C_A-T-p1"/>
        <property type="gene ID" value="C3_02510C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638371"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302510CA"/>
    <dbReference type="CGD" id="CAL0000190503">
        <property type="gene designation" value="SAP8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02510C_A"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="Q5AEM6"/>
    <dbReference type="OMA" id="TSGETWI"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="BRENDA" id="3.4.23.24">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="PRO" id="PR:Q5AEM6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000023">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424302" description="Activation peptide" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424303" description="Secreted aspartic protease 8">
        <location>
            <begin position="76"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="292"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0CS83"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P0CY27"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="P0CY29"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="21646240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="22302440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="23139737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="23927842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="27390786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="9802014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="15">
        <source>
            <dbReference type="PubMed" id="9802014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="16"/>
    <sequence length="405" mass="43037" checksum="A667BD901C6860A1" modified="2005-04-26" version="1" precursor="true">MVSIITFTKNVLVTLAFALLAQGLAIPEDIDKRAEKVVSLDFTVTRKPFNATAHGQHHQSQQQQQQQQQQPAQKRGTVQTSLINEGPSYAATITVGSNKQQQTVIVDTGSSDLWVVDSAAVCQVTYPGQSPTFCKQDGTYKPSSSTTSQNLGKAFSIRYEDGSSSQGTVYKDTVGLGGASITNQQFADVTTTSVDQGILGIGFTGDESSPTYDNVPVTLKKQGIINKNAYSLYLNSASASSGTIIFGGVDNAKYTGSLTALPITSSNELRVQLSTINIAGTTVSASTTPVLDSGTTLTYFSQTIADKLAAAVGAKWNSYYQLYTSSCNLAGNIVFNFAKGVTISVPLSEFVLQDGNSCYFGVSRDSATILGDNFLRRAYAVYDLDGNTISLAQVKYTTSSSISTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGF6</accession>
    <name>Q5AGF6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">GCD11</name>
        <name evidence="13" type="ordered locus">CAALFM_C502170CA</name>
        <name evidence="12" type="ordered locus">orf19.11699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720534.1">
        <property type="nucleotide sequence ID" value="XM_715441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGF6"/>
    <dbReference type="SMR" id="Q5AGF6"/>
    <dbReference type="FunCoup" id="Q5AGF6">
        <property type="interactions" value="1213"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AGF6"/>
    <dbReference type="GeneID" id="3637755"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502170CA"/>
    <dbReference type="CGD" id="CAL0000197613">
        <property type="gene designation" value="GCD11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02170C_A"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AGF6"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="104"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000197613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="534" mass="58577" checksum="64F2F694ECB0DEF6" modified="2005-04-26" version="1">MSYDDIENATPDIVIGSTIEEPEEDYQVESDNELQAADHESSQINEESAKGKKSVAFTGLDEDEENAEELARKEFEEGGGLPEQPENPDFNELTPLSPEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCDNPECPEPDCYRSFKSDKEIRPKCQRAGCDGRYKLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHEKSIIQFIRGTIADNAPIVPISAQLKYNIDAVNQFIVNYIPVPMRDFTASPRLIVIRSFDVNKPGADVDELKGGVAGGSILTGVFKIGDEIEIRPGIVTKDDQGKIQCKPIFSNVVSLFAEHNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGNLPSIYADIEINYFLLRRLLGVKTEGQKQGAKVRKLEQSEVLMVNIGSTATGARVVAVKADMARLQLTTPACTEINEKIALSRRIEKHWRLIGWATIKKGTALEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGW9</accession>
    <accession>Q3MPI3</accession>
    <name>Q5AGW9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C701570CA</name>
        <name evidence="3" type="ordered locus">orf19.13922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721405.1">
        <property type="nucleotide sequence ID" value="XM_716312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGW9"/>
    <dbReference type="SMR" id="Q5AGW9"/>
    <dbReference type="STRING" id="237561.Q5AGW9"/>
    <dbReference type="GeneID" id="3637040"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701570CA"/>
    <dbReference type="CGD" id="CAL0000178814">
        <property type="gene designation" value="orf19.13922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01570C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031475_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AGW9"/>
    <dbReference type="OMA" id="GRFVMTN"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971228" evidence="2">
        <location>
            <begin position="18"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="378" mass="42460" checksum="EF3B539DD3E2595C" modified="2005-04-26" version="1">MITLLIFIFAFLGNVLCYPQAILSHQISPKVMIVSMFQPEEEAWTSKVDFQHNITVPGLHPLYPNVHCTSNFDICQFTTGEGEINAASSIAFLISNSKFDFSKTYWLLAGIGGGDPAKVTTGSVTFAKYAIQVGLQYQIDSRELTNTNHKEGWTSGYFSYGTKHPQDYPDSVYGTEVFEVNEKLRDRAMELSRKNEKLLKLGDDDNVSLRKLYSSPANKIPTILACDVLTSDNYFTGHVLNDYFSSYSQLITNSSANYCSSAQEENATLESFIRVAKNGLIDYERIVILRTISNFVAKPKDLSIDPIEFFNEYPKGGIQHALDNLYIGGWPFVEDVVNNWDSLYKDGQSFRAENYLGDILNTLDGQGKDFGKDSYHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGZ0</accession>
    <accession>Q3MPG6</accession>
    <name>Q5AGZ0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">ISU1</name>
        <name evidence="11" type="ordered locus">CAALFM_C701760CA</name>
        <name evidence="10" type="ordered locus">orf19.13901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721384.1">
        <property type="nucleotide sequence ID" value="XM_716291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGZ0"/>
    <dbReference type="SMR" id="Q5AGZ0"/>
    <dbReference type="FunCoup" id="Q5AGZ0">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AGZ0"/>
    <dbReference type="GeneID" id="3637007"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701760CA"/>
    <dbReference type="CGD" id="CAL0000192594">
        <property type="gene designation" value="ISU1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01760C_A"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AGZ0"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000192594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="187" mass="19959" checksum="74D98DCADDB3ADF2" modified="2005-04-26" version="1">MFTRTILPTTRRILTQQSRVLVPRLAIPTSTFTRSYHEKVIDHYENPRNVGSLNKESSDVGTGLVGAPACGDVMRLQIQVDEETGKIKDVKFKTFGCGSAIASSSYATELIRGKTLDEALDIKNTLIAKELSLPPVKLHCSMLAEDAIKAAVKDYQSKRKTTTLGATAASTVSSSSASAAAPATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH29</accession>
    <accession>Q3MPD5</accession>
    <name>Q5AH29_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C702080WA</name>
        <name evidence="9" type="ordered locus">orf19.13862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721347.1">
        <property type="nucleotide sequence ID" value="XM_716254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH29"/>
    <dbReference type="SMR" id="Q5AH29"/>
    <dbReference type="STRING" id="237561.Q5AH29"/>
    <dbReference type="GeneID" id="3637025"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702080WA"/>
    <dbReference type="CGD" id="CAL0000200475">
        <property type="gene designation" value="orf19.13862"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02080W_A"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1686316_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AH29"/>
    <dbReference type="OMA" id="YACYELD"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF26">
        <property type="entry name" value="GRX1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTAREDOXIN"/>
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    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="74"/>
            <end position="136"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000200475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="156" mass="17779" checksum="6BA47C9B9702F6D8" modified="2005-04-26" version="1">MDYFQTEKTTETRQQRQQKKRPVRNSIICTLSLSYQPNFVMSSLIGWLSSWFQNEPITPELKKEIESNINSHKVLVYSKSYCPYCTSTKTLLQSLNQDYKVIELDQIPKGSAIQNGLQELTGQRTVPNVFINGKHIGGNSDIQALHSQGKLKPLFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI48</accession>
    <accession>A0A1D8PCZ0</accession>
    <name>YFAS1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>FAS1 domain-containing protein CaO19.3004</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C103120WA</name>
        <name type="ORF">CaO19.10522</name>
        <name type="ORF">CaO19.3004</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721502.1">
        <property type="nucleotide sequence ID" value="XM_716409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI48"/>
    <dbReference type="SMR" id="Q5AI48"/>
    <dbReference type="STRING" id="237561.Q5AI48"/>
    <dbReference type="EnsemblFungi" id="C1_03120W_A-T">
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        <property type="gene ID" value="C1_03120W_A"/>
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    <dbReference type="GeneID" id="3636926"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103120WA"/>
    <dbReference type="CGD" id="CAL0000186184">
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    <dbReference type="VEuPathDB" id="FungiDB:C1_03120W_A"/>
    <dbReference type="eggNOG" id="ENOG502S3U5">
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    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="PRO" id="PR:Q5AI48"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Mug57-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1">
        <location>
            <begin position="247"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="410" mass="46453" checksum="A4FBE83C214F1BAB" modified="2005-04-26" version="1" precursor="true">MKLSKLLQLAVFSSLVTSKNIFDLESLKQGLQDEETVNNDKREPVNLLYLDRFKMGVSDEAKGNAKFKRDPKNVIDPASLKEGSAEEEQKDKREPKNLFNLQALHEGLKDEETKSKREAKNLPNLEALEEALKGGSLPKKDAKNLIDLVALKQSLEKEAAKRDAKNIPDLEALKTGIEEEEGQVAKRDAKNVINLSNFIETPSKREGKNLFDLTKFQQSGQPIKKRDQKILKQEKSLFVLNSVDCFNNLLQSILPQLSSISIFSSYIRQFASIDARTANPQKVMLIVAPDNDSLETKLSDLKPWEFPEQITPEQSEQEQDKTLKNNLLHFLNGHLINNFEENLVIDKSSTDAVTIISKLNNGKFLKIKQDQLSQKFSIRLLDSENWIDVETIKQVENGFVLIINDSLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AIA8</accession>
    <name>Q5AIA8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Put4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">PUT4</name>
        <name evidence="9" type="ordered locus">CAALFM_C102570CA</name>
        <name evidence="8" type="ordered locus">orf19.10462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721444.1">
        <property type="nucleotide sequence ID" value="XM_716351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AIA8"/>
    <dbReference type="SMR" id="Q5AIA8"/>
    <dbReference type="STRING" id="237561.Q5AIA8"/>
    <dbReference type="GeneID" id="3636801"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102570CA"/>
    <dbReference type="CGD" id="CAL0000183611">
        <property type="gene designation" value="PUT4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02570C_A"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="Q5AIA8"/>
    <dbReference type="OMA" id="FWIFFPG"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000128">
        <property type="entry name" value="Proline-specific permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="49"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000183611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="564" mass="63565" checksum="3D1D463DB5F97858" modified="2005-04-26" version="1">MSKKNDNITYDVEKISIENPLPAKEFNDFHDKLDVEKYGETKRKLNSRHVNLLMIGQSIGSALFVSIKNPLHNSGSLSFFLAFAIWACLVIYPLMQAIGEMCSYLPIKGSFFHFSARYVDPALGFASSLIYTYTALMFVCIEATACAGLISFWTDINPGVFITIALVLFFLLNLFGAQFYGEFESIFSSFKVILILGLMLFSLISMCGGNPQHNAYGFQHWKEGGLFRPYLVGGTTGKFLGTYNCLIWAGFAAGGPDVLALIAAEVKMPRKNIGIVAKRSYIRIYLFYLGGIFFLNCLIASNDPSLVKSLKSSTVSPWTLGIQNVGVRGLGSVVNGAVLTSAFSCGNAFFFLGTRSLYSASLAGYVPRFFSKCLKSGVPINCVIFTGVVSLISYLNVSQSTGVVFNWFVNLATTGLLCSYICMWLAYFKFRKAYVVQTGKQMKKGEYPYYLAPKFIHPYFTYFGFFINVVVLFFNGFWIFFPGQFSVSNLFTSYFAPVFFICLFVFWKVFKKTHWRNAMEADITTGKQYIDEEEERDIEFELNRERRKGWFFVACRKASDFCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKX4</accession>
    <name>Q5AKX4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ran-specific GTPase-activating protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C113650CA</name>
        <name evidence="1" type="ordered locus">orf19.12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722207.1">
        <property type="nucleotide sequence ID" value="XM_717114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKX4"/>
    <dbReference type="SMR" id="Q5AKX4"/>
    <dbReference type="FunCoup" id="Q5AKX4">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="3636191"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113650CA"/>
    <dbReference type="CGD" id="CAL0000195642">
        <property type="gene designation" value="orf19.12470"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13650C_A"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014536_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AKX4"/>
    <dbReference type="OMA" id="QSMFFTA"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000195642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW26967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50418" checksum="8F99B29AE76703B0" modified="2005-04-26" version="1">MDQILLKASNQAVSFAIRSGISLASGYAIKTISTFLDKIPESSKLHQKIIIKQKKLKSKIDIITITIDLIKLAAIKGGGNGNGNSGGNTILQNSLQLINDLQIEFNEFDNNINELIKNLSGNNEKESIKQVENYMNSLLDDINEAIPILNLVLVTSGVNFNGNVNIHGISPGRLLQAANYINNSSGGGDNDDDNDNSTIGPVFDLVTYSIFYNPSRLKYIDGEIDELACINWKETYARSSVSIKKLKDYHYQLTIIEDFNDGRYHDDEDDKENKPGEMVIDLNSVQSMFFTASGKLLRLEERSSPVLIIKILKNGVEEWIALGELNQGEFDDDEDEDEDSQDEDTKKPVNKINAKLIKNSSLSLLEYLIRLCRLQEIECKSILEIPDEILSFYLHDKVNDLSDSGYLPKSLSQRQKDELKKMNKENTMTMDSNINRLKNLDIKEPKKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AL27</accession>
    <accession>A0A1D8PFK8</accession>
    <name>AKR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase AKR1</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ankyrin repeat-containing protein AKR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AKR1</name>
        <name type="ordered locus">CAALFM_C113220CA</name>
        <name type="ORF">CaO19.12414</name>
        <name type="ORF">CaO19.4950</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Early endosome membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722161.1">
        <property type="nucleotide sequence ID" value="XM_717068.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AL27"/>
    <dbReference type="SMR" id="Q5AL27"/>
    <dbReference type="FunCoup" id="Q5AL27">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AL27"/>
    <dbReference type="EnsemblFungi" id="C1_13220C_A-T">
        <property type="protein sequence ID" value="C1_13220C_A-T-p1"/>
        <property type="gene ID" value="C1_13220C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636166"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113220CA"/>
    <dbReference type="CGD" id="CAL0000187472">
        <property type="gene designation" value="AKR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13220C_A"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AL27"/>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="PRO" id="PR:Q5AL27"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0040">ANK repeat</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212919" description="Palmitoyltransferase AKR1">
        <location>
            <begin position="1"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="507"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="664"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 3">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 5">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 6">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="536"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="1">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="813" mass="91741" checksum="6A27A94506E7AA90" modified="2005-04-26" version="1">MAKKKSKSKSSSPKPKVSSTAAKPVEIDNQQNIENVQDSPSALQQQSATAEESENTATTATPSEGTTATTESSPVTTSNETDPIELSVLDNADHAIDSNSIKSTEAVLETLDSELNTIADTKTEPPTEQELNPTLAKYMRSCQEGNLTIVKELISSGQVLVNDTFSDEITGLHWACINNRLSLVKFLIANGANPNQLGGELKASPLHWACRNGLVYIVDYLMRNSDADPNLRDAQTYNALHLAVHSSNIMLVIYLLLSCCSTDSVKKVYIDEPDGSNRTALHWASYQNDIFTINALLRFGADVSKVDNSLFIPLHWAFMKGYKSVLKALVEAGSDIYFKNDQNKNSFDIAKDMNCSNTWEKVLIETGRDPKNNWAPLKPWVSAKLGKIITFLTPYFLLPLSFNVLSMGGDQGGFIIPKLILAIGILGGGIYLLNKLIISQYIFDDKKLAKSPILAGVFSATAFWSVLVWLYNILPTTFIHNFFANVIMAILIAIFTWSFFKAMFINPGFVPTPADNNVILSQVAQLIELGKFDTDHFCVNSFVRKPLRSRYSKHNKRLIARFDHSCPWVYNDIGVRNHKIFITFVYSLNMAIFVFLYLSLQYFDKVKDQYDSDDEGEGEGFVCSILGDDMCYGYKNHHFHFNVFMWDLFQCVWVSFLCIVQTFQILKGLTTWEFSSLNKQLQTNRFNHSTVPRDFEAGEGISLDQTQPSDGQHRHNHNEFQTCMNLLGIDQFILTLKMSLKSLFSNTRHGNNNTNYDPLTSLHIPTDHGIKQNWLDFWIIGEEKWRNVFYLPIDGENNLNGKVVDYYTLYSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALP4</accession>
    <name>Q5ALP4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAM complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">SAM37</name>
        <name evidence="9" type="ordered locus">CAALFM_C202160WA</name>
        <name evidence="8" type="ordered locus">orf19.9107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722576.1">
        <property type="nucleotide sequence ID" value="XM_717483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALP4"/>
    <dbReference type="SMR" id="Q5ALP4"/>
    <dbReference type="STRING" id="237561.Q5ALP4"/>
    <dbReference type="GeneID" id="3635750"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202160WA"/>
    <dbReference type="CGD" id="CAL0000191785">
        <property type="gene designation" value="SAM37"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02160W_A"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078884_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ALP4"/>
    <dbReference type="OMA" id="PMWYNTP"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000191785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="356" mass="41621" checksum="50DDCA5ABAD580AB" modified="2005-04-26" version="1">MLQLHVWGKDNEISIISPSCIASAYLLNQVLTPQNIEFEIIPSNNTNLSDINQLPVLIDNETKEKYNGYNEIIRFIESKYLSTSTKLSLVSYLPSDSLKTTKEKLINKGLINLLINKFEYINQYNLYLNNKNYENYTRKLFSSYLPFPMMYNQPSKYYAQAQEQVKILGLSKQKVSFFDFTTGNNEQGSIDVAPTELINDEDDEEGDEDEDGANVAISSLHERQLLKKSKSKQVLKESRNSMKCLILITQYIERFKTIFQHQQRDSDEEFGFIFNNQNPSSSEILFYAYIFCLTYEKLPDRFIFNYLKLKQDYTLKFITEIMNKNQISKNKFRNPIGNEIPSLTNEVKYWIGSIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMM1</accession>
    <name>Q5AMM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">TOA2</name>
        <name evidence="12" type="ordered locus">CAALFM_C401680WA</name>
        <name evidence="11" type="ordered locus">orf19.12095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722697.1">
        <property type="nucleotide sequence ID" value="XM_717604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMM1"/>
    <dbReference type="SMR" id="Q5AMM1"/>
    <dbReference type="FunCoup" id="Q5AMM1">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AMM1"/>
    <dbReference type="GeneID" id="3635710"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401680WA"/>
    <dbReference type="CGD" id="CAL0000177370">
        <property type="gene designation" value="TOA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01680W_A"/>
    <dbReference type="HOGENOM" id="CLU_112964_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AMM1"/>
    <dbReference type="OMA" id="QYYELYR"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000009">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="10">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000177370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="130" mass="14654" checksum="1B0F9E9ED58B4180" modified="2005-04-26" version="1">MSAPAYYELYRRSTIGVTLMDALDTLISDEKIQPQLANRILINFDRIIAENLKNENIVGKSKLIFKGDLDTYRFCDDVWTFIIKNVIIKLNDVSSKDSGGGDKDKDSGDLELNVDKFKIVACNSRKAGEM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AND1</accession>
    <accession>A0A1D8PK41</accession>
    <name>MTC6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MTC6</name>
        <name type="ordered locus">CAALFM_C305020WA</name>
        <name type="ORF">CaO19.13392</name>
        <name type="ORF">CaO19.5971</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MTC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723182.1">
        <property type="nucleotide sequence ID" value="XM_718089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AND1"/>
    <dbReference type="FunCoup" id="Q5AND1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AND1"/>
    <dbReference type="GlyCosmos" id="Q5AND1">
        <property type="glycosylation" value="18 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_05020W_A-T">
        <property type="protein sequence ID" value="C3_05020W_A-T-p1"/>
        <property type="gene ID" value="C3_05020W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635170"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305020WA"/>
    <dbReference type="CGD" id="CAL0000178984">
        <property type="gene designation" value="orf19.13392"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05020W_A"/>
    <dbReference type="eggNOG" id="ENOG502QVFP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033723_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AND1"/>
    <dbReference type="OMA" id="WGTIDPQ"/>
    <dbReference type="OrthoDB" id="5573651at2759"/>
    <dbReference type="PRO" id="PR:Q5AND1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407772" description="Maintenance of telomere capping protein 6">
        <location>
            <begin position="18"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="18"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="614" mass="69768" checksum="AD1BD65A2A796A2E" modified="2005-04-26" version="1" precursor="true">MTSLLFAFSLFLSFSVGSIFPFSISNGPAVNDTLQNAIRSQRDVSKPIPIDRVGFSGVSLSLFFESEGYSSDSLSNLNGLLKENVDGVMIDLYWNEFTSKWQLCPAPFPNNITYTTASNRIVDVSWNNKTYKCDPNLSTDNIMSILNSFIRDTNTDVEANFMHVMYNLKSIHYEKSNQTISLENIYKEKNSNLNVVGMDTLNDTVSLLSSYIFTPTLLKQYQSTSNKYTNSSSSIRYIDSLNETQAIQDFYSQSTILMPSLQTVLLTQYKRLMVHVVTNDMAESSRSYQISSSDKDTIFFNSDLPASIFHTDNASADELCYELSDAYNGTDVNIAEFNKVSLNATLRLVVDDDKTPFTTKSLSKYVRCGYCPIFNSTEYSSQKVTEGNSSIISREFASNLFWSWAPGQPSGPDNCINCTRPTTNNTSKHSDDNGEEEEEGNNIAYKCVALTEEGWEVSNCYEKYLFACQNKLSRNEWKLNNSTKRNYFDIDDDDCPEGYFFSLPRSNIEMLSLMTTVKQENVNYPIWIDLNDITVENCFVSGGPYAQCPYQETVTTDKFVRMIAPSFVVAMVVLVLIFIEKVFRKTPIQTNRKRYWKKAIHEYYAKNDYEGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANG9</accession>
    <name>Q5ANG9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C304740CA</name>
        <name evidence="9" type="ordered locus">orf19.13355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723146.1">
        <property type="nucleotide sequence ID" value="XM_718053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANG9"/>
    <dbReference type="SMR" id="Q5ANG9"/>
    <dbReference type="FunCoup" id="Q5ANG9">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANG9"/>
    <dbReference type="GeneID" id="3635251"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304740CA"/>
    <dbReference type="CGD" id="CAL0000178060">
        <property type="gene designation" value="orf19.13355"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04740C_A"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ANG9"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="PRTPISMRASEI"/>
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        <property type="entry name" value="TOP1Ac"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="PROSITE" id="PS52039"/>
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            <dbReference type="CGD" id="CAL0000178060"/>
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        <source>
            <dbReference type="EMBL" id="AOW28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="629" mass="71869" checksum="54D11B4857AF8689" modified="2005-04-26" version="1">MRILCVAEKPSISKEVANILGGGRKKVRNSREKFIKNYDFTFTFNSEDGPCQVTMTSVAGHITGLDFGSAFSWGNCVPGRLFEADIKTIITKKSIYENIAEEARNADKLMIWTDCDREGEYIGFEIMNAARKYNRNLGLNNIWRARFSHLERNHIIRAAKNPVNLDMSAVSAVSCRMEIDLRVGTSFTRLLTDQLRQKGIIEKNELASYGTCQFPTLGFVVDRYKRVKSFTPEPFWYIEIETRKENKKTIFNWVRGHFFDKMYVVMLYDRCCKSGEFGTISKIESKRKPNFRPFPLTTVELQKDCARFFKMSAKTALAAAERLYNLGYLSYPRTETDRFAKETDFKSLLEVHKQDPRWGSYTTKLLNEGFETPRSGSHDDKAHPPIHPIKYVSLDTLNTLDEKKVYEYVVRRFIACCSKDAVGTQTVVTLKWGDEFFTASGLMVHEKNYLEVYTYKKWESSKQLPKFTEGEQVKLSSGILKDGKTSPPNHMTEPELIALMDANGIGTDATIAEHINKIETRHYINKLKKGKNEYILPTPLGMGLIEGLEKMEFEDVSLSKPFLRKSLERSLEDIATGSRPKVDVLNTTIGVYVDAYSVCSHQILVLCNECRRIILGNSSNNNNNNNNNT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AP87</accession>
    <accession>A0A1D8PEW4</accession>
    <name>AIM21_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM21</name>
        <name type="ordered locus">CAALFM_C110090CA</name>
        <name type="ORF">CaO19.12342</name>
        <name type="ORF">CaO19.4878</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mitochondrial migration along actin filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <text evidence="1">Cortical actin patches.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723562.2">
        <property type="nucleotide sequence ID" value="XM_718469.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AP87"/>
    <dbReference type="FunCoup" id="Q5AP87">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AP87"/>
    <dbReference type="EnsemblFungi" id="C1_10090C_A-T">
        <property type="protein sequence ID" value="C1_10090C_A-T-p1"/>
        <property type="gene ID" value="C1_10090C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634817"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110090CA"/>
    <dbReference type="CGD" id="CAL0000178029">
        <property type="gene designation" value="orf19.12342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10090C_A"/>
    <dbReference type="eggNOG" id="ENOG502S25J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336152_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AP87"/>
    <dbReference type="OrthoDB" id="4096963at2759"/>
    <dbReference type="PRO" id="PR:Q5AP87"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000399514" description="Altered inheritance of mitochondria protein 21">
        <location>
            <begin position="1"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
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        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="377"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="424"/>
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        <location>
            <begin position="475"/>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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    </feature>
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        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="848" mass="93190" checksum="DF9B68FF63EF2A27" modified="2017-05-10" version="2">MPDSEPLEPLNQESSSNTEQLKLSTTPNIPARPQTRPQKQSTTTTTTVPTDQDSTTETSLEKPLDNPQDELDELAHEIEKVLSDPVIPPRPQHGSSTKSSETQTEHKEHDFEPAHPAIPQRPTNKKETIQSEVGDHNNGLESKSDLKVNKETSDDSVSTDKDKVHIKPSIPTIPSRPQSRNLDFSEVDNTKPSTTPSIPARPQRQSTTTQDEYKPQASNTPDIVTRPQTKTEKSVSNEELDKPGDEPSSKDQDNERHTDDSNASKSILETEKAVAQEEKKAKKSDVDNKPSEPTTSTDSSTEPTAPARGFRLPLHMQQGSGPISTSTPVAGSEAELNSLNNSNTFGDGEVTPGNSDTKATFKNDEDVENENRTDSSSFDDDMETISQDNEDGEQDRRNRQETATEENAQESEAPQFETTIIESGETEERDGDDTDSGELYSEQQQNKEKEETVPATSTPKIPQRPPKKSSLSRATTNDSLTSLNSTSKPPKPVISKRPTTEESLSNIEPTIPSRPAINQIPSVGESQHEPIVPNRPGNKDLASSQKDTQVSVKSKPPPPKPKKLSSKIAAFQQQLFNPANASSEEDVSSTGSKQPESGIRKRSTENSVLSRFGGKAIPLPGMFNPNQMPKPSISHGEETSDDKEEKQESATANAPVRRTRGPRGKKLPKAVADAEVKTESRFAIESGKLWSIEFKKKIVEEKEIISTSVEDLKKPKILSENDEAGDESKETAVENEVIDNPEIPVKDELQHDVVDVVGHPEKDVVTGLDDDDEDVPPEVNERFIKDEEISNVGVERTIASETTTEKHSTDEEEVEEEAEVDSVDIPIRRVAVNTVDSTEVQKDVEDEP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-06-20" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q8X1E6</accession>
    <accession>A0A1D8PPZ3</accession>
    <accession>Q5AC19</accession>
    <name>CDC37_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Hsp90 co-chaperone Cdc37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cell division control protein 37</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CDC37</name>
        <name type="ordered locus">CAALFM_C602610CA</name>
        <name type="ORF">CaO19.5531</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2001-07" db="EMBL/GenBank/DDBJ databases">
            <title>A Cdc37 homolog in Candida albicans interacting with Crk1 kinase domain.</title>
            <authorList>
                <person name="Ni J."/>
                <person name="Chen J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.</text>
    </comment>
    <comment type="subunit">
        <text>Forms a complex with Hsp90. Interacts with a number of kinases such as crk1.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-7148504">
            <id>Q8X1E6</id>
        </interactant>
        <interactant intactId="EBI-7148532">
            <id>Q9Y7W4</id>
            <label>CRK1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF397024">
        <property type="protein sequence ID" value="AAL56555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719095.1">
        <property type="nucleotide sequence ID" value="XM_714002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8X1E6"/>
    <dbReference type="SMR" id="Q8X1E6"/>
    <dbReference type="FunCoup" id="Q8X1E6">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="IntAct" id="Q8X1E6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="MINT" id="Q8X1E6"/>
    <dbReference type="STRING" id="237561.Q8X1E6"/>
    <dbReference type="EnsemblFungi" id="C6_02610C_A-T">
        <property type="protein sequence ID" value="C6_02610C_A-T-p1"/>
        <property type="gene ID" value="C6_02610C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639210"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602610CA"/>
    <dbReference type="CGD" id="CAL0000192456">
        <property type="gene designation" value="CDC37"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02610C_A"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033261_1_0_1"/>
    <dbReference type="InParanoid" id="Q8X1E6"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000195065" description="Hsp90 co-chaperone Cdc37">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="508" mass="58564" checksum="89E4EDDEBF322868" modified="2002-03-01" version="1">MPIDYSKWDKIEISDDSDVEVHPNVDKQSFIRWKQRDIHEKRMQRNIEIKSILIQLTMYAKLNERVDYLLEKLTSTELLDSEKVMSKLNSEFDPQEKFDYDKLIKDKGSTLRKGLKDLKFDREEIENTPCYNEMIEDLFVQIKDDHPETKTDGDKLIEYLKEHRNRIDDVLSKQTIKLDDLLYQKAQLIVSDDLHTGFDRSFLNKDKPEEKEENQDKPKAPEAKKTTVTTTETINSPKPVEENTDKEILDELEILPATKEFAKIPSDNLSKAAEFLIKHPSICTEQQKDALIMTAFDLQLENKSDEAKHIVHQSLLLQYVGQLSDNGKAAPANVINAIKLFFSKIAAESSPAKHAFLEDVNQTFNHIKGRCEIIKEEQKQNAANKEGTGEEEEEEALIQLKALDDNTELSVNIPQEGTKEYEIFTTKLPIEFQNAIKTESIDEVNKEFAKLKIEDAERILEIFNECGVIGISGYIEDEKEFEELKKEYAHETANQEEDQSASVEDTVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q9UW23</accession>
    <accession>A0A1D8PN95</accession>
    <accession>Q59YH9</accession>
    <name>MATA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mating-type-like protein A1</fullName>
            <shortName>MTLa1 protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MTLA1</name>
        <name type="ordered locus">CAALFM_C501740CA</name>
        <name type="ORF">CaO19.3201</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Science" volume="285" first="1271" last="1275">
            <title>Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Hull C.M."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="10455055"/>
            <dbReference type="DOI" id="10.1126/science.285.5431.1271"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION IN TRANSCRIPTIONAL REPRESSION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Cell" volume="115" first="389" last="399">
            <title>Evolution of a combinatorial transcriptional circuit: a case study in yeasts.</title>
            <authorList>
                <person name="Tsong A.E."/>
                <person name="Miller M.G."/>
                <person name="Raisner R.M."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="14622594"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(03)00885-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2002" name="Cell" volume="110" first="293" last="302">
            <title>White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating.</title>
            <authorList>
                <person name="Miller M.G."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="12176317"/>
            <dbReference type="DOI" id="10.1016/S0092-8674(02)00837-1"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="764" last="775">
            <title>Hemoglobin regulates expression of an activator of mating-type locus alpha genes in Candida albicans.</title>
            <authorList>
                <person name="Pendrak M.L."/>
                <person name="Yan S.S."/>
                <person name="Roberts D.D."/>
            </authorList>
            <dbReference type="PubMed" id="15189997"/>
            <dbReference type="DOI" id="10.1128/EC.3.3.764-775.2004"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription both of homozygote-specific genes and of genes necessary for the white-opaque switch, a prerequisite for mating.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with ALPHA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Moderately repressed by HBR1 in response to hemoglobin and growth signals.</text>
    </comment>
    <comment type="miscellaneous">
        <text>The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).</text>
    </comment>
    <comment type="miscellaneous">
        <text>Most C.albicans strains are heterozygous at the MTL locus and do not readily undergo white-opaque switching and mating, but mating occurs in hemi- or homozygous strains. Mating takes place in opaque cells, produces tetraploid progeny and seems to occur rarely, if at all, in nature. Conservation of mating capacity is rather thought to be due to the simultaneously regulated white-opaque switch, which seems to play an important role in host commensalism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MATA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF167162">
        <property type="protein sequence ID" value="AAD51404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330959.1">
        <property type="nucleotide sequence ID" value="XM_019475414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9UW23"/>
    <dbReference type="SMR" id="Q9UW23"/>
    <dbReference type="FunCoup" id="Q9UW23">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9UW23"/>
    <dbReference type="EnsemblFungi" id="C5_01740C_A-T">
        <property type="protein sequence ID" value="C5_01740C_A-T-p1"/>
        <property type="gene ID" value="C5_01740C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643729"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501740CA"/>
    <dbReference type="CGD" id="CAL0000200104">
        <property type="gene designation" value="MTLA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01740C_A"/>
    <dbReference type="HOGENOM" id="CLU_1669146_0_0_1"/>
    <dbReference type="InParanoid" id="Q9UW23"/>
    <dbReference type="OMA" id="QIRVWFT"/>
    <dbReference type="OrthoDB" id="4026277at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900239">
        <property type="term" value="P:regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000049172" description="Mating-type-like protein A1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD51404." evidence="7" ref="1">
        <original>L</original>
        <variation>F</variation>
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10455055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12176317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="14622594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15189997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="210" mass="24712" checksum="5C29262F177BD4DC" modified="2011-10-19" version="2">MNSEIESSLTLLKSVEKLVQATSVYKNEDNEEIFLQLKRERQENSNSHEETETLFHESLDRLMKLSSIAGSKVQYELSLNNLYNLLLRTRKQEEEEAFIFPTVSTEEFALEQITFEVSDQMDDDKDSEDDILIKGEEIKKSKKKRQRLDNSTKEFLEKVFEKNKQPNRRERELIAEKHGVSLSQIRVWFTNKRMRKKEPKSKAKSSSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCA8</accession>
    <name>A0A1D8PCA8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">CMP1</name>
        <name evidence="17" type="ordered locus">CAALFM_C100730CA</name>
        <name evidence="16" type="ordered locus">orf19.13454</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718995.2">
        <property type="nucleotide sequence ID" value="XM_713902.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCA8"/>
    <dbReference type="SMR" id="A0A1D8PCA8"/>
    <dbReference type="FunCoup" id="A0A1D8PCA8">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCA8"/>
    <dbReference type="GeneID" id="3639328"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100730CA"/>
    <dbReference type="CGD" id="CAL0000201614">
        <property type="gene designation" value="CMP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00730C_A"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCA8"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004723">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071473">
        <property type="term" value="P:cellular response to cation stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="196"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="438"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000201614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW25770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="609" mass="69624" checksum="76983B3F4F4BEDFC" modified="2017-01-18" version="1">MSGNTVQRNTEQINNALNAIQHRRTTTGNESNTNTNQRQILQNPTGRDYTIYVTDDGEKYSTVERAVKSVDPPATFKPKDEQVFYPNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKEPNLLSVPAPVTICGDVHGQYYDLMKLFEVGGDPASTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEELYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDDDNLDQEYVTNVVRGCSFAFTYKAACKFLDRTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSEAEIGVTPTTTTTGATPVSPKAYPPSSRITSPHKSTKLVESRANEEEKSNDGDDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGADGLKNTINSFEEAKAADRVNEALPPSPEDLQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCI9</accession>
    <name>A0A1D8PCI9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ABC1</name>
        <name evidence="8" type="ordered locus">CAALFM_C101450WA</name>
        <name evidence="7" type="ordered locus">orf19.10842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718154.2">
        <property type="nucleotide sequence ID" value="XM_713061.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCI9"/>
    <dbReference type="SMR" id="A0A1D8PCI9"/>
    <dbReference type="FunCoup" id="A0A1D8PCI9">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCI9"/>
    <dbReference type="GeneID" id="3640239"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101450WA"/>
    <dbReference type="CGD" id="CAL0000176669">
        <property type="gene designation" value="ABC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01450W_A"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCI9"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="220"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000176669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW25836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="566" mass="63995" checksum="151C33F594539620" modified="2017-01-18" version="1">MSISKSIYELAVIANSLGKVLEGSSKIVQNEAYQWYKSSFVSKIIQDSCDNSQPMYEEMQNISTTIRNQVSPNINQKENPFQSQSQKRSYSTKSYSPGDEVELETESTSSNTVPDIKPKLTKTFEMSQSEVPSSRLARIFHYGSLAAGIGLNAATQGLRHYASGNSDAITMKSLVLSPQNIERMARKFSKMRGAALKLGQMLSFQDASILPKEIQQILLRVQNSAHYMPPGQLERVMSKELGLNWRERLFTSFDDVPIAAASIGQVHTAVAEDLTPVVVKVQYPGVVDSIDSDLNNILMLLTASSLLPPGLFLDKTIANARVELKWECDYIREARNLVRMREFLKDDDAFEVPRVFHQLCGEHVLTMERMRGIEIVKGDWGQSTKDWIATNIMRLCLLEIKEFKFMQTDPNWANFLYNEKTHKIELLDFGAARDFGDHFIDNYVKLLRAAVKKDRKRVEEISKDLGYLTGLESPQMVKAHVDSVMCLGEAFSPVDNNGEPFNFKKQTISDRVRGNVGLMLNERLTPPPEETYSLHRKLSGVFLLCSRLNATVPCEDLFREIIGYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCJ9</accession>
    <name>A0A1D8PCJ9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arp8p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ARP8</name>
        <name evidence="3" type="ordered locus">CAALFM_C101700WA</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718182.2">
        <property type="nucleotide sequence ID" value="XM_713089.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCJ9"/>
    <dbReference type="SMR" id="A0A1D8PCJ9"/>
    <dbReference type="FunCoup" id="A0A1D8PCJ9">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCJ9"/>
    <dbReference type="GeneID" id="3640200"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101700WA"/>
    <dbReference type="eggNOG" id="KOG0797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCJ9"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="772"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1066" mass="121353" checksum="54385203CD70B3D7" modified="2017-01-18" version="1">MRKTKLNANSLKHSTTNQKITQYEEKNRQHHCHHQNNNNLLIQLKQSNSLTMSDAINPPTSPYSVDIDMIDDSGAATPILSSQADDIILPSEDPESPTNPNATGTSSSTTTNTATNKINAGGATTTSTTKSSSSSSSSGGGVIGDSESSAQKRHKPGPTAGKRPSAETLQRRKEGRIKAAATLAQNLAKTGIGRFENENGFNLTSIKPISVINQKNYFTDYLKKDEQVSFIRNWRQERALQQKMKKLKQQQQQNNQQNNQQQLDNGEKKETKNFDDFNLNDIELEMKKEMAVSGGTTTTGAGNDDDEEVDDEENETEEVRQEKAKIGEDVIVLQPGSRYIRIGKATDAVPLVIPNVIAVKKNLTNIVNPHGDDSGIKYPKRKLKQPKPSSSTNKHDQDDENEEELEYYIDEEFDEQKAIVTKDFRARMRYYKRRILPNSRETVINFNKRQVSEKIEDHNDPNKKEWINPDKQTNKRFFVGEDALNLATKNPNQVNTSKDGESQWILRYPMINGNFNENSYYYESREEILGDICNIIFDALNQLEITTDVNKYKVMLLIPDLYDKAYVETWCQLLLKFIGFGKVGIIQESIATTFGATMSTACVVDVGAQTTKISCVDEGMIISDSRVLLNYGGDNITETFVKLLIEDQFPYRDINLINAIDWELAQNLKEKYITFQDADIAIQLYEFYKRKPFESTEKFTFKIFDEVMLAPMGLFFPKLFQITGNKHPSIPNYYTSKNPTKSTVENLFSKSLDQYNNKPNNPKSKSQDQLKSKNQLNYCDLTDEELLLKLINQNDNENDTTEKDDEHQHQSQVNGTSTTTTSKTKNNEDQLLSSNFDGEDERLVEVPLEKAIIESITNAGLSSDLTKLKKFYDNIIIVGGGLSKINGYDLILNDRLNIWRPRILSTSAIDLIIKYLNEEIKKNLLKKENLIEIEQERIKQEMESTMSGDNNNSTTNNNNNQEETTAQNNNINVSEIEVPEDIMERINNETELKLDLDYIEELIEENGQFLSMNIVPTPREFDPSMINWKGGSVYSRLKVVNEMWITQNDWDLLGSRSLYYKSIFNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCQ5</accession>
    <name>RL26B_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L26-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL26B</name>
        <name type="ordered locus">orf19.3690.2</name>
        <name type="ORF">CAALFM_C102330CA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330618.1">
        <property type="nucleotide sequence ID" value="XM_019475073.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="9=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="9=1-127"/>
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    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="9=1-127"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="9=1-127"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="9=1-127"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="9/BT=1-127"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="9/BT=1-127"/>
    </dbReference>
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        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="9/BT=1-127"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
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        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="9=1-127"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="9=1-127"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
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    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCQ5"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PCQ5"/>
    <dbReference type="FunCoup" id="A0A1D8PCQ5">
        <property type="interactions" value="953"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCQ5"/>
    <dbReference type="EnsemblFungi" id="C1_02330C_A-T">
        <property type="protein sequence ID" value="C1_02330C_A-T-p1"/>
        <property type="gene ID" value="C1_02330C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30514969"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102330CA"/>
    <dbReference type="CGD" id="CAL0000201086">
        <property type="gene designation" value="orf19.3690.2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02330C_A"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCQ5"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456511" description="Large ribosomal subunit protein uL24">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW25918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="127" mass="14185" checksum="CF9CB3FAEE3B597E" modified="2017-01-18" version="1">MAKISQDVSSSRSKARKAYFTASSVERRVLLSAPLSKELRQQYNVKSLPIRQNDEVLVVRGSKKGSEGKVNSVYRLKFAIQVDKLQKEKSNGASVPINIHPSKVVITKLHLDKDRKALIQRKGGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCZ5</accession>
    <name>A0A1D8PCZ5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ARP7</name>
        <name evidence="3" type="ordered locus">CAALFM_C103310WA</name>
        <name evidence="2" type="ordered locus">orf19.10545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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                <person name="Weissman J.S."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="5 6" key="2">
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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        <scope>GENOME REANNOTATION</scope>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713633.2">
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    <dbReference type="AlphaFoldDB" id="A0A1D8PD64"/>
    <dbReference type="STRING" id="237561.A0A1D8PD64"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C103810CA"/>
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    <dbReference type="InParanoid" id="A0A1D8PD64"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000185343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="392" mass="43978" checksum="C027194B7C44EE0C" modified="2017-01-18" version="1">MESLRPLTQIKKSNKKLPSLVDISLSTIKKHIHSITDIGTTPYHLLEPILQQIPAKQLNELELNCSQLLPYSDKLWMKLILKDFPDRPPPPPPSAATSPIKLNQKHGGGSGGICGLDMPYKSLYYKYCQDRDEFRKDSAKRLRHANKSLERQKSKNKIVAIDEVLRDPTIKSRRFYDLPAYTNNRKSYGMMGNKNSILQKAKRDTIVNRTLIFGGNNGSGTNRHLNRYDPFDAFKVDKKSSISSLSTGSKFIRPPKTTTTNNNNVRPGVRRTTFFNSAGSGQSTATTTKRAQPFDSNNNNEPNKVNPSIASDTKSNLNSAPDSKQNCETNNTTTTARQPSIFLQFKRKSSIMTNDLTSTKKKKAKKSNNQSELLEVNETPSKLKPLKSSIFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDB5</accession>
    <name>DUR3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spermidine transporter DUR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DUR3</name>
        <name type="ordered locus">CAALFM_C104650WA</name>
        <name type="ordered locus">orf19.8403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="43748" last="43758">
            <title>Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins.</title>
            <authorList>
                <person name="Kumar R."/>
                <person name="Chadha S."/>
                <person name="Saraswat D."/>
                <person name="Bajwa J.S."/>
                <person name="Li R.A."/>
                <person name="Conti H.R."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="22033918"/>
            <dbReference type="DOI" id="10.1074/jbc.m111.311175"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>TRANSPORTER ACTIVITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="e61480" last="e61480">
            <title>Histatin 5 resistance of Candida glabrata can be reversed by insertion of Candida albicans polyamine transporter-encoding genes DUR3 and DUR31.</title>
            <authorList>
                <person name="Tati S."/>
                <person name="Jang W.S."/>
                <person name="Li R."/>
                <person name="Kumar R."/>
                <person name="Puri S."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="23613860"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0061480"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="Antimicrob. Agents Chemother." volume="58" first="756" last="766">
            <title>Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis.</title>
            <authorList>
                <person name="Tati S."/>
                <person name="Li R."/>
                <person name="Puri S."/>
                <person name="Kumar R."/>
                <person name="Davidow P."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="24247141"/>
            <dbReference type="DOI" id="10.1128/aac.01851-13"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Major spermidine uptake transporter that is also used by salivary gland-secreted histatin 5 (Hst 5) to enter into candidal cells (PubMed:22033918, PubMed:23613860). A major component of host nonimmune defense systems is salivary histatins, a family of small (3-4 kDa), histidine-rich, cationic proteins secreted by major salivary glands in humans and higher primates. Hst 5 is the most potent of the 12 histatin family members and has fungicidal activity against blastoconidial and filamentous forms of Candida albicans (PubMed:22033918). Hst 5 cojugates to spermidine to be uptaken by DUR3 (PubMed:24247141).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>spermidine(in) = spermidine(out)</text>
            <dbReference type="Rhea" id="RHEA:35039"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:35041"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 5">Decreases significantly spermidine uptake (PubMed:22033918). Reduces significantly salivary gland-secreted histatin 5 (Hst 5) mediated killing (PubMed:22033918, PubMed:24247141).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713591.2">
        <property type="nucleotide sequence ID" value="XM_708498.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDB5"/>
    <dbReference type="SMR" id="A0A1D8PDB5"/>
    <dbReference type="FunCoup" id="A0A1D8PDB5">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDB5"/>
    <dbReference type="EnsemblFungi" id="C1_04650W_A-T">
        <property type="protein sequence ID" value="C1_04650W_A-T-p1"/>
        <property type="gene ID" value="C1_04650W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644760"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104650WA"/>
    <dbReference type="CGD" id="CAL0000194064">
        <property type="gene designation" value="DUR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04650W_A"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDB5"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015847">
        <property type="term" value="P:putrescine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015848">
        <property type="term" value="P:spermidine transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015840">
        <property type="term" value="P:urea transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000459182" description="Spermidine transporter DUR3">
        <location>
            <begin position="1"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22033918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23613860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="24247141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="22033918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="725" mass="79568" checksum="8345A17F62A02FE8" modified="2017-01-18" version="1">MADSYVPLPQSAGYAVVVGLGFVFAFGMMLTTYILRRYNKEVMTAEEFATAGRSVKTGLIAACIVSSWTWSATLNGSTSQVYNNGVCGSIFYAMGATVQITLFACLAIKARERAPAAHTYLEIVKGRYGTTTHFVYIFWGIVTNILVTSMLLSGGSATVNDLTGMNIVAAILLLPLGVVIYTLFGGIKATFLTDYAHTVVLIVIIFIFAFTTWATSSKLGSPQAVWEIVTKLAESNPREGNAGGSYFTMHSRSGGMFFVINIIGNFGTVFLDNGYFNKAFAANPSSTYKGYIFGSLAWCAIPALCSLTMGFAALALEHTEYWPLGRPMTAAEVASGLVLPNAASALLGKAGAVLALLMVFMAVTSAMSAELIAVSTIATYDIYRTYINPNASGKKLIWVSHLSTVIFAYTMAGFAIGLYYAKVSMGYLYEMMGVIIGGAVLSSALTILSKRQNWHAATFSPIISTALAIMAWLVCTKKKFGSVTYLKTFEDDAMLTGNCVALLTPFIIVPILTFIFKPQNFDWKLLDQRITRVDEEEELAEALGGTVSSDPERLHPIKSQISVIASQLVEGEREQYQKEKEILNKSFKICCIVCCTLAICLVVLFPMPLYGTKYIFSKKFFTGWVVVFIIWLFYSAFQVIIFPIWESRTDLYHTFRGIYWDLTGQTYKLKAWQNEHPEEMHAVRSQLQAQLSRTAVTHEIVDGKAFGDGYVTPANIDDALEEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDH0</accession>
    <name>A0A1D8PDH0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidyl synthase</fullName>
        </recommendedName>
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Magee B.B."/>
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    <reference evidence="14 15" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
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        <text evidence="2">Belongs to the NCBP1 family.</text>
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        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:nuclear cap binding complex"/>
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        <property type="term" value="C:nucleus"/>
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    </dbReference>
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        <property type="term" value="P:filamentous growth of a unicellular organism"/>
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        <property type="project" value="CGD"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CaGCR3 protein"/>
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        <property type="entry name" value="Sto1p"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="CBP80"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007413"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022664"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
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            <dbReference type="ARBA" id="ARBA00022884"/>
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            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00030965"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000190077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW26480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="886" mass="103128" checksum="BEB223BDC8864B4E" modified="2017-01-18" version="1">MEFSNKRSRDDFEQDEGQFHDGPSHDSFDHKRHHIDPAQELINNICKDIRRLGEAGDIENLIADTNYISNPIVAEFEKIDNLRNSILSTIYALITEQPHKISAIANLILICNAKNFVIAKYVIEYLHSKMQTMLDSQEGSVFNDIKNILKFLSTLTPIIEDNGIIQIFKQFLNFAIELQEQTEVRNGLAQEIYYNVLIAIPYVLSNDNSDDLKKSINELIELARNFKIVAESATVLLPFDTRMGNFELPYIPKQMVDLILPALIKLQNDDWNFRLFLDFKTHLDPVIQSALENNSISSELVKHKLPQLSFPSVENASFKSTSIDKLWNDNPRYLFQVYNNTTEYETVPPIETYLGLFFKDIAFDILTNLSFNKNETAIELSILDMFFDNKLFAPPGTSIDQLNAIYEDNKSGTNDPSLSTWKIEDVAVESILTMIFQLPNPLEVEIYYYTVLISCCRESPESIAPVFGRAIRYFYNHLETLDYELKIRFLDWMSIQLSNFEFSWKWEEWVSDSKKLKDLKYHPKKNFIKNLIAKEIRLSNKKRIKDSFIDIVDGEVVNLDEFYQYLDISMVPDVKSYIISYDTELYGESSRDTLIQLYEQKQEQLNSKSNIGAQNEIFFNFTNSELPFHETASKVYDFILTHWKSNTDFNELYKSVLESITAPNNERFAINLIIQTYAYIGSRSIYSVVSILSRDINKLKFLSGAPIDYVGDEARFEDLHFTEEEKQNRQNWIIEAVFRIWIHQPQVVFLILEYLIEFGIIDPKYILVKALESNLIIDNVSCMESINRILSKAESKELIIQLFTAIIDNLNKLELDKEKRVEIEEVTESNATEVDKQWLFYEYLGLLKSYYRKYIIGDVECHDKVKEIVGQLENASAKDEILKWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEE7</accession>
    <name>A0A1D8PEE7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">CTR2</name>
        <name evidence="6" type="ordered locus">CAALFM_C108620WA</name>
        <name evidence="5" type="ordered locus">orf19.12183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_709974.1">
        <property type="nucleotide sequence ID" value="XM_704882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEE7"/>
    <dbReference type="SMR" id="A0A1D8PEE7"/>
    <dbReference type="FunCoup" id="A0A1D8PEE7">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEE7"/>
    <dbReference type="GeneID" id="3648427"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108620WA"/>
    <dbReference type="CGD" id="CAL0000189658">
        <property type="gene designation" value="CTR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08620W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PEE7"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000189658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="162" mass="18579" checksum="A10050DA65006FBA" modified="2017-01-18" version="1">MDHFEHSDVGSTVSYHNMDHNMPGMEDKCSMNMLFTWDWKNTCIVFKWWHVKTEIGFVLSLLAIVLLGALYEFVKAWFSKWERNELATLGASNASTITQEKRFKIKRGVLYGFQVIYSFWLMLVFMTYNGWYMLAVGVGAGLGNCIWGSSSESSSSRSLSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEH3</accession>
    <name>A0A1D8PEH3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Stress-responsive transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">MSN4</name>
        <name evidence="11" type="ordered locus">CAALFM_C108940CA</name>
        <name evidence="10" type="ordered locus">orf19.12215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Weissman J.S."/>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716288.2">
        <property type="nucleotide sequence ID" value="XM_711195.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFE8"/>
    <dbReference type="SMR" id="A0A1D8PFE8"/>
    <dbReference type="FunCoup" id="A0A1D8PFE8">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFE8"/>
    <dbReference type="GeneID" id="3642011"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112450CA"/>
    <dbReference type="CGD" id="CAL0000177461">
        <property type="gene designation" value="IRA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12450C_A"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFE8"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900233">
        <property type="term" value="P:positive regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000177461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2643" mass="304867" checksum="2C6D16BF8736B8B0" modified="2017-01-18" version="1">MSDSIMKDDHFIFIQALAKRIESLLPNHTGRSIEEVELDQQFSITRKLLLENNSKDPRTVTYILVTFASILKTINTEFTNNKLKYRDDKSRNSILLICKLLADVLKVSWDRESTIVDDKDFLSNYSKFYYYDTPNRIESSVVSDLVDTFVNMISSSVVRKVVSLVRNEQTLTTLIVAKEESEILREDQLMTKEEETELVIGKIDFYLDTIIRYIATANPEDYYDVLKAKIFRYSQRDATIPLPVLQTYLPLLKFIFFAKVNSVTIVDDTLKALPCIRSNTWKQVYLHFLASSIKAQSFSRTLDYNVLVDLNDTHQTQVARSLFDISFSLFSDESSTNSFNSPFVLIWFFVICLEDVIEVSSDKPLNKLKLTFNKRLKFIMSQLKESSNASSLGSFDSFIHLFHLGARLQAYNQLWHPIYKFSMKFLDEIHQNLIKFGEVRKDDLLVDDDLLFRYDLLTVNFYLAAILINSDKYIRIVINNYKQNQEDLRFNKIFVKIIKGLSEIQTAKKSFFATMKQVTPTLRLMVYGASKILYQYEIRRSINQISQGSINGSSDASTASYIDNEQNSDEVTAATQEAFSRIKTSLDHYTADLFDTDLKKLNSSKNFTTSSSSVLSTSTYRFRVVNGAEELLSDIFRIFAAAPEFYFNDEKLMSKKVYETKPLSESLPPIIRFCHDAIIPIRLAFKSKWIIQGDTRLLDSTKELSLKMVEPTTSLIDIRTDLSVFANFQICCCIIYVTCEACLSISLLNPKFKSCFLFLNSFLQKRTYFNKFVIENPILTNPDTRVYLGFCGDIIHSVEKVLLLSLCTHDISFYNYALQGIDWYLDEVETNKPFYPSEDVRDTLVDTFQKISEDKAVFTGFVSLHKRHRNILRNSKPTKSLYQTWVTIYHRWVRILDTKSSLGNDKTLILRHFTGFLVSTSGCFLSGSLVSEELAANTWPTAPISEFFDKCIELLTSPDMVIQMIIKEALASESQAEVYCLTARKLMETATHYFENNKSDEIAVFLDRAIIVMTSMINVKSEGALYLSTLLPEICQDFIKFINAIDDPCERFKLQLRFCKLGCALELDRTNAGLNGAYKLRNLYSRASLEWLEPAVFYDSALEENIKADDSSSVKTNKEVELSHLALDFAVECSILLRGQVENLLLEVPDGIKEDEINKYKDLSFSVYFSLFYKVIQKYTKATPTNREKHKHHIIIDNILQSITNILQYDSQIGMRFILPMGYHESKKIRSIFLNVFSKMLVHQSKISNREEYPDKLINELTDQFEIFGSIAECASSFEHNLLASAFFEVFSYTGKLNNLFNVLLNTEVALSSRSTDLFRRNSTLTKFLSFYAQTNGVDYLNEVLLPVIKELVDNDVQFEVEKQDNSDTADLFILYLSRIIDSIVNSTDKLPHAFKSVSKAIYDSVSNKFPEAALTAVSSFVFLRFLCPAIISPEQHFKLPINNPKVKRSLMQLVKVLQNMANGTLTSIKWPAIAGKTEELNFYNQKIDGFLKIISTDVTTENQSAELYKPEKPLTSLRYLHKFIYHYFAKIRYNFLFQHSWRCNYSLHDKAVKFKKFDYLVMQMGQPNPGVKLQMSSKLKLLDTNNLDEEEIKLNDFMTKMSIKFSDTPPDAIDVIHSSIFKDGTPAVVVNLKKLSGRPHDFEYLAYKLIETASQVWDNKFYLVYDFTEYYYYIETVTIEYANLIANSGTKLLFSNCQRVYYFNIPRIENPGIMEGVKLVRSKGEKYGTKVYIYSLADPDSIIKNLCLDSETLAINRENKVTFKDVLLYDATTEKFMPVQFKIGRRFVTLCFTNRVKFDYIASVTDGFNPVEVYRISEMNKCEVSNFTGNNDEFTIYLNRGVQLTFRSQDRLEILRYLYFTISRLPREPFSLNNELDYQNERHTMHWFGRLYNIVFQGLLSHDEELKSKAGVLFGSLSTYFEIDFGIRENHASNVPFPADATNFVVTVSAHLAKTFPQMTYRFFKAFFDNFDRIDRETRFTSILYLSPWIQNIYEYVFSNDENGADKTADLLRLFCRLTSIYKDRIPFINDYIWSKLFQEARLVSTLVEEVVAFAIDSKNDNPDWTFIIAVICPSIEVCGEVTSRLLQRINKVVTTDSSIALQSKLFEISVLIKICSSLFFNSYNLAKTYLAELIFFVTLFIDNPVLDVGEDLQKLLMTAIQSFLHKPNLTEAQRAEIDKAIAYFSTPRAKMIFGTSRDVTKRNDAAQAFNKITNIEQFADYLNVFIKAFALHGDRTNWRARWSSNTIDVAFNNYSVFQDRAFLMVGILSKEGISDSNACRTIKLVSNGELNSIDITICVAVAVARILDGLPDSSILPPILIWPQLCFTLLNHAVLYPSGLENVIASITKIMRLGPNYLDTIFEQQQYLEPDLSKFQERHGYIITKENFGVHIFFILGQGLRISQYRHLAIACIKRYFKQRYLMREGKTMDGKFITNNTYAYIFYLYLCCDAKEVEDYLKELEIDRSFISLDDNQKIPKLLIDLLFDNTEVSKILMIHVGFLFCDIQGVDISFKARFIQIYLYMLKNNRELALLVYHIIKPTLMHDLLNTVSVEVVKNISEIVEIVSQCTDYDPEYHKNVVDDILISKKITILKTLRHLKPLSETIDENQIFKPEFDSDIKPIQSMLYRAACSYISGSKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFV0</accession>
    <name>A0A1D8PFV0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">FTR1</name>
        <name evidence="9" type="ordered locus">CAALFM_C114130WA</name>
        <name evidence="8" type="ordered locus">orf19.7219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715020.1">
        <property type="nucleotide sequence ID" value="XM_709927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFV0"/>
    <dbReference type="FunCoup" id="A0A1D8PFV0">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFV0"/>
    <dbReference type="GeneID" id="3643318"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114130WA"/>
    <dbReference type="CGD" id="CAL0000185056">
        <property type="gene designation" value="FTR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14130W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFV0"/>
    <dbReference type="OMA" id="SVWHLDC"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000185056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="381" mass="42505" checksum="9C9FAF9A9557690F" modified="2017-01-18" version="1">MVDVFNVQIFFIVFRESLEAIIVVSVLLAFVKQSMGGSSDPQLKKRLYRQIWLGAGLGVLVCLIIGCAFIGAFYGLGKDIWGNSEDLWEGIFCIIATVLITAMGIPMLRINKMKEKWRVKLAQALIKSPTNKKDRFKLGYLGKKYALFILPFITCLREGLEAVVFVGGVGLNSPATSFPIPVIVGLIAGIVVGALLYYFGSSMSMQIFLIISTCILYLIAAGLFSRGIWYFETNTYNKKTGGDASENGSGPGTYDISKSVWHVNCCNPETDNGWDIFNAILGWQNSATYGSVISYNIYWLFIICVLLLMVYEEKHGHLPFTKNLTLVQLNPMYHIKGKKKLELNKAEKDELFTKLQQQNFGQAAEVDETSSNKLIESKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFX1</accession>
    <name>A0A1D8PFX1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">MLH3</name>
        <name evidence="4" type="ordered locus">CAALFM_C114400CA</name>
        <name evidence="3" type="ordered locus">orf19.7257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715055.1">
        <property type="nucleotide sequence ID" value="XM_709962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFX1"/>
    <dbReference type="SMR" id="A0A1D8PFX1"/>
    <dbReference type="FunCoup" id="A0A1D8PFX1">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFX1"/>
    <dbReference type="GeneID" id="3643294"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114400CA"/>
    <dbReference type="CGD" id="CAL0000176790">
        <property type="gene designation" value="MLH3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14400C_A"/>
    <dbReference type="eggNOG" id="KOG1977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFX1"/>
    <dbReference type="OMA" id="FECAHGR"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="441"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000176790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="636" mass="72417" checksum="E5E960F90F743E13" modified="2017-01-18" version="1">MIVDKKEKGFFLVSTKKKILFPLSTMILRLDESVITQIRSHTIFHSLDSVVRELLQNSLDAGANEITIKIDLSSLSVYIHDNGTGITPDDLEKVTLQHYTSKWHSHNYKGEALFALKVISNLTIISKAPDYTTPFKLNNSVAELYNEYSGGYFQIGDINPQGTVVIAANMFRNIPVRREQIRTTPHAKLVEAIKVAVLESLTPNARVNLKIFLVNHTTLQLDQIVAICGHSPLLFQLFGVKTKFEPVRAKFKNIKVVGVIGREPITAKHQYVFVNDRRVTLSLGESKRLNDLFSSSGFNDIDFRTKTTGKPFYKHPTFMFRVYPGKREVVQDSYTWNIVLRIIYKIIAKFLDRRQPPKPLLSTPPIHRTSDKYILTTKTKLGFLKENEIDGLVDNRPYHGKEAPLPRIPTIAHLPHQCTSTHTTPHLTSSQTNLAPEKFRVINQVDRKFILLAADDQLVVLDQHASDERIRVEQYLQEFVSQPNPGLRLHSPIAFGVHASELMLFDQYAANFNSFGICYTTDTAQVVITHLPLILLTKVEDDAEFLKDSLLQHCYDLHDHVKRISPNFDNWFETSYHLPRIITELINSKACRSAIMFGDILTKDEMQDLVNKLSRCKLPFQCAHGRPSIVPIANLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH54</accession>
    <name>A0A1D8PH54_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ifa4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">IFA4</name>
        <name evidence="3" type="ordered locus">CAALFM_C204420WA</name>
        <name evidence="2" type="ordered locus">orf19.11986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712936.2">
        <property type="nucleotide sequence ID" value="XM_707843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH54"/>
    <dbReference type="SMR" id="A0A1D8PH54"/>
    <dbReference type="STRING" id="237561.A0A1D8PH54"/>
    <dbReference type="GeneID" id="3645454"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204420WA"/>
    <dbReference type="CGD" id="CAL0000199289">
        <property type="gene designation" value="IFA4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04420W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PH54"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="677" mass="78246" checksum="A28E65BF4E7F4F2C" modified="2017-01-18" version="1">MVIVSFNIDTDLFINLAKLPAEVIALIFSFVPKCMLPELLYCSPIKKVAASAILSYVDVYDAIERHKWSYELGVGYPNCSCRQFRITQENLKQGIRQWKIFPKSIALNNVDQLAIALNDSREFFVDAQLINASFLEIGYHDYEGVFRDFLKSRFKFSCLTLSNHRNPLTLPPIAINVKLSKIKLNSYVIPGVKKLELDVPKNQEERLTFSAELEDLIINSDRSIQVTLPPNLQKLEVYAFQSSVHFISEKMVNLEYLTIQLPNIRSFDETGIIAPNLKELKVRCDQLSNLEELRQFQHLKELEFGFCNYPFGLFNEGSFPELEKFRCRECSCSASEDFDNSLLTFPPNLKKFEIEIFRFQNVNFGSLVLPSTLTRLKLKNFPFDYDYLVDSLQYIDVHTVKLTLKSDFRIPHMAKEFILAAEYFSIDSIDFMYHLPSNLIHLSLHAIESGQMKSLAQMVKWPPMLRKFTLINFNIDHFKLKQLNLKESRLTKIHIYQGNVKTLDAGLFPVSVKDLSLTEMGIQQLPDSFENLENLQKLYLWQNQLRDVTSVKLPMATLETLDLSICNLRFISPFLVSMFEEKNKNAKLRVIAKENANVSVIDIRRALKAIKGLSLDLDEFDKTLIEISKHSSRLDCEYRCYDFCIEEPETDDLYNGSESGLDEESSGTKKKRRNIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHD8</accession>
    <name>A0A1D8PHD8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">RPC40</name>
        <name evidence="10" type="ordered locus">CAALFM_C205340CA</name>
        <name evidence="9" type="ordered locus">orf19.11048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BZZ1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_716678.1"/>
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        <property type="gene designation" value="BZZ1"/>
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    <dbReference type="eggNOG" id="KOG3565">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
    <sequence length="620" mass="69510" checksum="438012A523D05F67" modified="2017-01-18" version="1">MSIETISIGNELKDSYKSTSKWVNNGINWLQDISDFYQERSNLEKEYSTKLKELTKKYFDKKSKLSASLSVGDEPAITPGSLENASLVLWTDLLTQTEAIADEKSNLSREFQSKIADNLITLKNKCERVANLANSINDYLVEEKNKFEDEVNKAKKHYDSLCQTTETARDKNEKAPNDKHQKKLDEKQVIMNNGKNEYLIKINVANRLKDKYYYQDVPEILDYLQELNEDRVELMNKLLKNASIIERNSADKVKEKLHAIDQTIEQNNPKLDITMFIKHNAVDWKEPQDFYFIPCSFWHDDESLIIKEPELTELKKKLSIASNEYYKFEQSCIDVKQKLEESTNKRKRDNENITLKFDTGLQGSLSILHKFMKEDTNRVKNEVEIEVIQNFAGDKDLTYVAPVKEKKSRFGFLTGNHKKSQSGGGGGGGATQSDASSEVHSLNPVKTSTSLHSGIFDLRRNKSIASTVSGGVGNGAASIQARALYDYTAAGSDETTIVAGDQLSVIEEDDGSGWTMVNGPQGQGLVPTSYIEITSRGPPPSSQQPQQKKKGPSVAPRCGAKKVQYLEALYDYTADGDDEISITAGDRIVLVQDDTDGSGWTEGELNGQTGMFPTSYVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ98</accession>
    <name>A0A1D8PJ98_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C301510WA</name>
        <name evidence="3" type="ordered locus">orf19.9265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_716677.2"/>
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        <property type="gene designation" value="orf19.9265"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01510W_A"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
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    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="248"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="632" mass="70731" checksum="D7EAD4CB3C70335D" modified="2017-01-18" version="1">MTARDESTVPLSRRQRLMGLARNTRDNYIPKITGSVSSFASGASRAFTNTDVYDENGRILLPKDSTIQLFPSYTRHQDGKYFVDVQGWVFTPGVMNRKNRVVLSVVKQIMKQRETSRAALNSIENDSTMKQEVFNPDSASSDTESIISVDSSHSSRSSNASLNPDDVIKERLSSFFARSIPNTELSITIGSESKVDNLKQLYISTDGYGHFETTIEVPYKPSVIQASSKLVDTVFAFQDINVYSNSGIGIISDIDDTVKLTGVIGEKMVLLRNLLTNEVSSWSIPAVIKWYQNIYKRENVSFFYVSNSPWQLYNTINEYFQHTGLPPGSVHLKRYSGNIIASLLEPSSSRKRRALHKILQDFPDKKFVCIGDSGEHDLEAYVDLARSFPNRILSINIRYVEDSFSDDNDQKIYNEVIRLITLKRKEIPKTTDTLKPSANKKSLSPSADDQIEDLIDLSDASVQQTPKKLPPMVPKKPTKLKGQNMTRKPPPPPPPPPSRNRGNTLTHSYTDSVMLSPHSTTQSSLPTSPPSSSNVASDGNSIDEELPPLPPRRQTSPSINSSTSHDSELDSICNSPGFIELEEYDQKGANWIKRIISSIHQLESVDTKLNIFKDDDDAFFKSSCIELDELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK11</accession>
    <name>A0A1D8PK11_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C304590WA</name>
        <name evidence="5" type="ordered locus">orf19.5917.5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330866.1">
        <property type="nucleotide sequence ID" value="XM_019475321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PK11"/>
    <dbReference type="FunCoup" id="A0A1D8PK11">
        <property type="interactions" value="1150"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PK11"/>
    <dbReference type="GeneID" id="30515204"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304590WA"/>
    <dbReference type="CGD" id="CAL0000200451">
        <property type="gene designation" value="orf19.5917.5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04590W_A"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PK11"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="74"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000200451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="227" mass="24023" checksum="244D10F26C671588" modified="2017-01-18" version="1">MSASLDKSLDDIISSNKKTFKSKRPGAKFGAKGGNRVGKKIGGTNNNKKPIAKFNKPAAAVAAAVPAIDLSYATKVNVSGLPKDLKHDNIKEFFQSQIGGVQTVALSYNEKGQFKGFATIVFKSSKFATAAVDKYNGASIDGGAAKLRLELIIDTSKKPLAARIAPNAKAAAAAKTAGGKKIAAAKNALNKKKAGPGNKNNNKQKKPKQKKKTIEELDQEMADYFEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK71</accession>
    <name>STM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-associated protein STM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosome clamping factor STM1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ribosome-associated protein CAALFM_C304810CA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">STM1</name>
        <name type="ordered locus">orf19.5943.1</name>
        <name type="ORF">CAALFM_C304810CA</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosome preservation factor that protect a small pool of nontranslating, vacant ribosomes in cells under nutrient starvation conditions. Under nutrient-limiting conditions, cells reduce ribosome biogenesis and degrade ribosomes via autophagy (ribophagy) or proteasomal degradation. To avoid excessive degradation during starvation, STM1 binds to and protects 80S ribosomes from proteasomal degradation. Under nutrient-sufficient conditions, TORC1 phosphorylates and inhibits STM1 to prevent formation of dormant 80S ribosomes. Acts as an inhibitor of mRNA translation by promoting ribosome hibernation: clamps the two ribosomal subunits, thereby preventing their dissociation, and inhibits translation by excluding mRNA-binding. Acts via its association with eEF2, promoting ribosome stabilization and storage in an inactive state. May also repress translation by preventing association of eEF3 with ribosomes. Binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilized by guanine base quartets) and purine motif triplex (characterized by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures. These structures may be present at telomeres or in rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Associates with mature 80S ribosomes. Binds to the head domain of the 40S ribosomal subunit and prevents mRNA binding by inserting its alpha-helix domain towards the mRNA entry tunnel at the decoding site, where it blocks the binding of tRNA and mRNA at the A- and P-sites (Probable). Interacts with eEF2; interaction sequesters eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation by TORC1 upon nutrient replenishment inhibits STM1 and causes its release from dormant ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330868.1">
        <property type="nucleotide sequence ID" value="XM_019475323.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CL/i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="8CQ7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="CL/i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="8CQW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.05 A"/>
        <property type="chains" value="CL/i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="8CRE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CL/i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="8OEQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="CL/i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="CL/i=1-267"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
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    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
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    <dbReference type="EMDB" id="EMD-13744"/>
    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="SMR" id="A0A1D8PK71"/>
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        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PK71"/>
    <dbReference type="EnsemblFungi" id="C3_04810C_A-T">
        <property type="protein sequence ID" value="C3_04810C_A-T-p1"/>
        <property type="gene ID" value="C3_04810C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515205"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304810CA"/>
    <dbReference type="CGD" id="CAL0000197338">
        <property type="gene designation" value="orf19.5943.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04810C_A"/>
    <dbReference type="eggNOG" id="ENOG502S4DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KKWAGAK"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045142">
        <property type="term" value="F:triplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043558">
        <property type="term" value="P:regulation of translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000456524" description="Ribosome-associated protein STM1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="112"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P39015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="11">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="267" mass="29072" checksum="4A11447A892771E2" modified="2017-01-18" version="1">MSFQNKNLYDLLGNDVEEDAAPSAPSREVVKKNTSSKKSDAAPASADPAKAKKKKSPTGNEAALKNKNFNKDVAPPQSTATKHSKKPFDRHSRTGKTDSKKKLQQGWGQSDKRELEGEVEGTEDAEAELEAEAEENDESANAIPKKSLQEYLAELELSKQELEGSKKLRQANEGAEQKWTAEEKIEKQQEVFFASTHTKKAKSKAQKEKVFLDIDANFGDEQPQTTRGGFRGGKRGGARGGSRGGAKRGGARGAAKPEVNDKNFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKC5</accession>
    <name>A0A1D8PKC5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 2</fullName>
            <shortName evidence="6">tRNA-yW-synthesizing protein 2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">TRM12</name>
        <name evidence="9" type="ordered locus">CAALFM_C305890WA</name>
        <name evidence="8" type="ordered locus">orf19.7369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716610.1">
        <property type="nucleotide sequence ID" value="XM_711517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKC5"/>
    <dbReference type="SMR" id="A0A1D8PKC5"/>
    <dbReference type="FunCoup" id="A0A1D8PKC5">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKC5"/>
    <dbReference type="GeneID" id="3641738"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305890WA"/>
    <dbReference type="CGD" id="CAL0000179804">
        <property type="gene designation" value="TRM12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05890W_A"/>
    <dbReference type="eggNOG" id="KOG1227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKC5"/>
    <dbReference type="OMA" id="FELNPWS"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026274">
        <property type="entry name" value="tRNA_wybutosine_synth_prot_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038972">
        <property type="entry name" value="Trm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000179804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="419" mass="48494" checksum="EE1659701D2C42EE" modified="2017-01-18" version="1">MAIKLLIDNPKQVKPIKSYLEDHNWLNKSFKIQKKNDIFHIFTNLNEIPSQLSQYNHETYEQEDDGDLNTKNKTTTLTLASIITDYCHANNIENIEIPKRWSIYPPMILFNSTGSTSESNGHPTSDTIFNPQHQKLWENVLSNQKSIFGTSEITHIALNKPIIESDIMRRPHNLIPIIGDFGPDISIDNKPPSPTESDFNRAFWCHVIQNGIYQTWAPKYTMFSRGNIKEKKRVLDWFKNLDQTIVFDFYCGIGYFSLSYLKNGGKLLCWELNPWSIEGFRRSLEKMKINYKIYTSGDKFSINDLNQFDACLFLESNEQITTRVIDQVKDNSLPISHINLGLLPSSKQSWTLANNLIDKSTINTNVHIHENVHIDDFEKIKTDVKKVFTNGKVLHLEKVKTFAPDIWHIVIDIENIKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLA7</accession>
    <name>A0A1D8PLA7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">NAT4</name>
        <name evidence="14" type="ordered locus">CAALFM_C401250WA</name>
        <name evidence="13" type="ordered locus">orf19.12134</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722734.2">
        <property type="nucleotide sequence ID" value="XM_717641.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLA7"/>
    <dbReference type="SMR" id="A0A1D8PLA7"/>
    <dbReference type="FunCoup" id="A0A1D8PLA7">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLA7"/>
    <dbReference type="GeneID" id="3635704"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401250WA"/>
    <dbReference type="CGD" id="CAL0000194507">
        <property type="gene designation" value="NAT4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01250W_A"/>
    <dbReference type="eggNOG" id="KOG2488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLA7"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000194507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="203" mass="24142" checksum="1646290026A37DF7" modified="2017-01-18" version="1">MEEIAEDLSLNYLTDRFRLPNFETYIEASHNMDENQIDKFIQLIDDNLGDLYVESEQYNWKNNKKEEMLEPGLVYIWFTETTPEEEEEEELVGFLSFKLCEDVDDVFVLYLFEIHLTQKYQGQKLGQSLIDQFHEFAKSLQNSSHELYSMLQGTALTVFSNNTRALNWYKKMNYELTEGSPMDRKLRNGTVIKPVLYLMRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLR1</accession>
    <name>A0A1D8PLR1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">BUB1</name>
        <name evidence="9" type="ordered locus">CAALFM_C403120CA</name>
        <name evidence="8" type="ordered locus">orf19.10193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720431.2">
        <property type="nucleotide sequence ID" value="XM_715338.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLR1"/>
    <dbReference type="SMR" id="A0A1D8PLR1"/>
    <dbReference type="FunCoup" id="A0A1D8PLR1">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLR1"/>
    <dbReference type="GeneID" id="3637922"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403120CA"/>
    <dbReference type="CGD" id="CAL0000187122">
        <property type="gene designation" value="BUB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03120C_A"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLR1"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000721">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="587"/>
            <end position="900"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="74"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000187122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="900" mass="103367" checksum="4FE235BAA1C5DD24" modified="2017-01-18" version="1">MVIQKSPQTANIQLLEQQKENIQPLSGGRSATKLTKALSSRPNSATSINYQEHRTKLEREREELEQKLLDSDELDDPLQVYIEYINWVHYNFPQGANADSGLVILLEKCTSKFRDVSHYKNDPRYLKIWLEYTNYSDSPRDIYVYLAKKEIGNQLALYYEEFARYLEAQKKYTDANQIYELGIQSNAFPLKRLQKSYENFKERLQLEMSSVSTTSDLVREALKVKRGSSVEPGAHVDHGPIAKKPRLEVFKDDDDQNQSVLHLIFGASLNDDIKLNSTKQRIKENTISATAWKGRVLKQKVPTPPNSSGGKIQVFRDFEPLAFQAKKSICYDEKGRAYTLIENPGKKSERVLVNMDLIYPDESQEFSMLELLAISRRSERQKQQKQTLINHPTVVDEDTRTITLALNNSSTIKSRDMDPTITMNGNLAHNELQGIYNELGYGYNFDDEDEKVQEPTVTNYDGYVTETINPPTTNANLIPTQVDSPQIDQVATPPTDREEEFDDRVLSSPFVEQPVANTQPVDPFDIGLQESFLDNLSIPMSTYSGYYDKSTTKVDRIRKFREITNKNQTINRGSSSAIIDYCGQELYCLLHELGQGGYGFVYLIEAGSTGKLKALKIETPSSRWEFYILHQVHRRLIGEAGYKQRYFIRAEALYYFQDESFLILDYCSQSTLLDVVNNYKNKGSSLEECLVIFFTVELLKALEALHSVGILHGDLKADNCMVRFEPINESDWSERYDRSGKFGWSHKSITLIDFGRAVDMTLFSSGTRFVSSFKADEQDCPQMNEGTPWSYEADYYGLATIIHTLLFGSYIKIKKDGSKIKLHANFKRYWQHELWQDLFELLLNPYSSAEVNHAPRTESLATIREHFENWLESNSKMKYLKGLIKMVEGELNSINRARVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLR2</accession>
    <name>A0A1D8PLR2_CANAL</name>
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        <submittedName>
            <fullName evidence="4">GPI-anchor transamidase subunit</fullName>
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        <name evidence="4" type="ordered locus">CAALFM_C403130WA</name>
        <name evidence="3" type="ordered locus">orf19.10192</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715337.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="3637921"/>
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    <dbReference type="eggNOG" id="KOG2407">
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            <begin position="18"/>
            <end position="621"/>
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    </feature>
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            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000190236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="621" mass="70598" checksum="F6D864F383A21A63" modified="2017-01-18" version="1">MNISILLVSLFLSLACADEIEPSGEFHEHLHLKPLSRNRLLTNFEFDVESSPFQIDYYNSSSPVEVSRRSHYNYFPNSLGLIIESTNTKELQLRFTQGWWDASSWGQLPFNGKYSGGTGVEVSAVIEAPNVEVAKRNWLKLTKTLSGFFCASLNFIDDHITTYPKHAVKEINLAEYAPEKGNKLYLLRAALPSEPVCTENLTPFLKLLPTRGKSGISSLLDGHKVFDSLWHGMSIDVTTNCDTNNQCTLKLHQTVNQVVDIIRSLRKRKEGAIPKPTPGDQLRCDTEKTYNSWQCFPLSDPVNLEWNLETIYGRGINGPALADDPQVSKVTIDIDPSSWNIMLLREKENSIEGSSLTNQEETNQIVQYLHENVKFDFQFIAQNSSIVLPIDTPPLYASRSLTGYSLDKGGLRTVFTNNNDEPVKFVYFESTPWFMRLYLHTLKLTLKNSTGLFDIFDHEQYIKDVYFRPAVDRERPSHMELIMEVPAKSTLAISYDFDKSLLLYREYPPDANHGFDVEPAVISVFDKDSEKVYEFRTTSLLLTLPTPDFSMPYNVIIMTCTVLSMVFGTIFNLLIKKVVTEEEFEEIAANTKLAKLKRGIKSTIQQLKGQKQANIQTQTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLX6</accession>
    <name>A0A1D8PLX6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C403920WA</name>
        <name evidence="5" type="ordered locus">orf19.9163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710086.2">
        <property type="nucleotide sequence ID" value="XM_704994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLX6"/>
    <dbReference type="FunCoup" id="A0A1D8PLX6">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLX6"/>
    <dbReference type="GeneID" id="3648314"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403920WA"/>
    <dbReference type="CGD" id="CAL0000174468">
        <property type="gene designation" value="orf19.9163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03920W_A"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLX6"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="435"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000174468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="568" mass="63289" checksum="84EBEDA3E026EA9C" modified="2017-01-18" version="1">MSSSISDWIRNFFQPSTSYQRVGTSSNSSIPGSFPTEQESNSPPHPPSSRISPVFNSQTINSTFRNLSSWLNYLLIQPLIIIILVIFRILSTIINVIYFQNQSPSIVNGSGGGGGSGSGIDGSTNNNSRCEFVDPVAKASKFIRDLEDNLQPPSILQGNDINSGGGGSNDTHSPITSATRPVSGTTVTTTTTTTSTTISNSERLPPFFQGSYTQALYMATKRGKFLFVYLTNPHNENANGIFNNIITNEIFLKIFRTNENIIIWGGDLTNPEAYQLANSLAVTKFPFLGLLCLTRSSKMTPEGPRKTVSKLSLVSKIQGNIINTQSLSLGLHQYQNQYQDTNFDDGNLSVANELINRKFLTKIAKYSPELNLIRQELQDKYMSQILLKQQELNYQKSLQADKLKKQKKQYDTLSKQYLIYQLDRFEKYLTKDRVANDNIAKIAIKLTNGNRVTGYFPSNNSIDDIFIFVELINRGYLNVANNSTTTTTTTTTTKLTSTLTESQALTKFKDFKLIYNFKLLSPLPPKICLNDVLSSSKDTTPTATTIKINQFDIIYPNGLLIVEDIQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM20</accession>
    <name>A0A1D8PM20_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BioF2-like acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C404190CA</name>
        <name evidence="4" type="ordered locus">orf19.12773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711557.2">
        <property type="nucleotide sequence ID" value="XM_706465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM20"/>
    <dbReference type="STRING" id="237561.A0A1D8PM20"/>
    <dbReference type="GeneID" id="3646860"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404190CA"/>
    <dbReference type="CGD" id="CAL0000184522">
        <property type="gene designation" value="orf19.12773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04190C_A"/>
    <dbReference type="eggNOG" id="ENOG502SI3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM20"/>
    <dbReference type="OrthoDB" id="10061051at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="BioF2-like acetyltransferase" evidence="3">
        <location>
            <begin position="729"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000184522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="848" mass="97125" checksum="1A45A60AD576984D" modified="2017-01-18" version="1">MIQQSTNSSDETESVSKQPQHQHHISPMNQLQSLNKEEVGKKSSKTDHIKQYIFKTVENMPTPKLMWLISPIAIVIYSTAFNIASEVLYSKFTYNSYGISFFKIAVLFLDVFIFLVVIYEQFYFTNDVHFTNKWSKYTYILICKILKKILWIILLIACVFQVIVISTGRLNNPLNIDNDYMQYFEMTPNEKTTYFIINLFSLIFNGAVLTIWWSTNISSVHSLFGLINLINILIGISISQINIVHIHNSHGANRRLHNWFIITGSFMTGQSAIGLSIVLLINEKNRLKDFIGKLIFFYDVYVAAVFCLLLGCTIVSGIYFNNDSSFPISIFILYLCSIIISVVSFMCTRYFRLRGGFTNNYQVEEYDLLSLTTHQKQGWGKLIDINRKYNGGISGDYVISLMENYIEAELSGMTCKVLRVFKKNEAGTSNLPSTASPVTSLSSSSSSSLSQKPKHQNKKNMNTAFEDLDPESLLFQDTPTLCDTTSSIKHLEDEYRPLSKNQLKRLAKKNQKDKKLLELKSLENNTEIFYQELMNTEALILLTIVEEFDLSERIPGWIGKKLNKWFGKNSKFPILCIRFGLLGFHWPFKRSTFYCSATKKPVARGAAVLYAISQWNAQHEKLTVLLDPTYKDVNFEAGITSSGWYKIKLPNSHIIDLRPFQNQTSTDYFKAIKYRTQDNSFKQAHGQVIETNVFNYENCQEIINMNQNISQNRQSSGQSQQLLQPDWEFIYNLGNFSNEKKYRSLLFLKVDNQIIASCVIFRLGDTMTSDIQGLDHAISKKYKAYFVMMQEVIKIGLREGVKFIDFGPTTEEAKVTIGCNVVPLCGSIYPKNKFLGPIIKFAASKVDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMM6</accession>
    <name>MNN4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase regulator 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MNN4</name>
        <name type="ordered locus">CAALFM_C406540WA</name>
        <name type="ordered locus">orf19.10399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="4" first="409" last="416">
            <title>The histidine kinases of Candida albicans: regulation of cell wall mannan biosynthesis.</title>
            <authorList>
                <person name="Kruppa M."/>
                <person name="Jabra-Rizk M.A."/>
                <person name="Meiller T.F."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="14734021"/>
            <dbReference type="DOI" id="10.1016/S1567-1356(03)00201-0"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="39628" last="39635">
            <title>Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition.</title>
            <authorList>
                <person name="Hobson R.P."/>
                <person name="Munro C.A."/>
                <person name="Bates S."/>
                <person name="MacCallum D.M."/>
                <person name="Cutler J.E."/>
                <person name="Heinsbroek S.E."/>
                <person name="Brown G.D."/>
                <person name="Odds F.C."/>
                <person name="Gow N.A."/>
            </authorList>
            <dbReference type="PubMed" id="15271989"/>
            <dbReference type="DOI" id="10.1074/jbc.M405003200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Med. Mycol." volume="51" first="385" last="395">
            <title>The mannan of Candida albicans lacking beta-1,2-linked oligomannosides increases the production of inflammatory cytokines by dendritic cells.</title>
            <authorList>
                <person name="Ueno K."/>
                <person name="Okawara A."/>
                <person name="Yamagoe S."/>
                <person name="Naka T."/>
                <person name="Umeyama T."/>
                <person name="Utena-Abe Y."/>
                <person name="Tarumoto N."/>
                <person name="Niimi M."/>
                <person name="Ohno H."/>
                <person name="Doe M."/>
                <person name="Fujiwara N."/>
                <person name="Kinjo Y."/>
                <person name="Miyazaki Y."/>
            </authorList>
            <dbReference type="PubMed" id="23101887"/>
            <dbReference type="DOI" id="10.3109/13693786.2012.733892"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2017" name="Front. Microbiol." volume="8" first="2156" last="2156">
            <title>Phosphomannosylation and the Functional Analysis of the Extended Candida albicans MNN4-Like Gene Family.</title>
            <authorList>
                <person name="Gonzalez-Hernandez R.J."/>
                <person name="Jin K."/>
                <person name="Hernandez-Chavez M.J."/>
                <person name="Diaz-Jimenez D.F."/>
                <person name="Trujillo-Esquivel E."/>
                <person name="Clavijo-Giraldo D.M."/>
                <person name="Tamez-Castrellon A.K."/>
                <person name="Franco B."/>
                <person name="Gow N.A.R."/>
                <person name="Mora-Montes H.M."/>
            </authorList>
            <dbReference type="PubMed" id="29163439"/>
            <dbReference type="DOI" id="10.3389/fmicb.2017.02156"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5 6 7">Golgi apparatus protein required for full protein phosphomannosylation, a modification of cell wall proteins that occurs in some species of yeast-like organisms and confers a negative charge to the wall, which is important for the interactions with phagocytic cells of the immune systems and cationic antimicrobial peptides (PubMed:15271989, PubMed:23101887, PubMed:29163439). While MNN4 seems to have a regulatory role in N-glycan mannosylphosphorylation, a transferase activity of MNN4 cannot be ruled out.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is negatively regulated by the histidine kinase NIK1.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6 7">Impairs the ability to bind the charged cationic dye Alcian Blue and leads to cell walls without acid-labile beta-1,2-linked oligomannosaccharides (PubMed:15271989, PubMed:23101887, PubMed:29163439). Does not affect cell growth and morphogenesis in vitro as well as virulence in a murine model of systemic infection nor interaction with macrophages (PubMed:15271989). Induces the production of higher levels of inflammatory cytokines (PubMed:23101887).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MNN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715537.2">
        <property type="nucleotide sequence ID" value="XM_710444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMM6"/>
    <dbReference type="FunCoup" id="A0A1D8PMM6">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMM6"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PMM6"/>
    <dbReference type="EnsemblFungi" id="C4_06540W_A-T">
        <property type="protein sequence ID" value="C4_06540W_A-T-p1"/>
        <property type="gene ID" value="C4_06540W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642784"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406540WA"/>
    <dbReference type="CGD" id="CAL0000174110">
        <property type="gene designation" value="MNN4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06540W_A"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMM6"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000463370" description="Mannosyltransferase regulator 4">
        <location>
            <begin position="1"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="217"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="14734021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15271989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="23101887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="29163439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="14734021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="996" mass="116258" checksum="524644F80DD4A1E5" modified="2017-01-18" version="1">MSNTIPQYFIRIFNLIFSARRKNFQLALISGLLFFGSFVILSTTSYSKKFNYFDDLILKIYDYNYLTNNYNIDYLAKNDPEAYFNVKVQQIVDEKKQHDLESKFWSLDTKINDDQATLQIPAYFTYNKPRDNKNLEDSEQSSKPVEKPLIQPFDPRFTLAMYYYYLDQQMTTAHHDSSSSSSENSITVPFNWYDWVDMSVLNKYLLAPNKDKPDCSILDAHEDARKIETEKKKMEKLAKQWDENKRKAEEEKKKAEEDKKKEEEEKKKAEEEEKQRHEQEKQALEEDKKKLEEEKKKIEEEKNKLQEQQQQQQEEKANDGNQKHSKFVKRDDEIKMSTSQDKSDSDSDRAKIDMTTFFNEAFEKLSDEDKASVAKDVEDAVKKITQPSSWCVPNAKLSIDHSDKQIVHPGFNVFKSPGRTTPQKAIIAGKSFLYSYAPPPSSILFLTSEGSYSVNVQHSAPLLRNGIPESYLANNNFDVSLNVLQQLHKLKKNHKPDTAKVINDYLLHIPKESFKYDPDSIIFDYTKRLDKGEKLTIKELKYLQSLEYSKDKVAHGGPPKYFAESRLIGTTVGDHYDWRFFNGVQFGTVDQSLTLHRLIRTWLSFTRKSGITTWIAHGSLLSWYWNGMAFPWDNDIDVQVPIMDLHKLSLQFNQTIVVEDPEDGFGRYFLDIGSFITLREKGNGNNNIDARFIDIDTGLYIDITALALSNSETPKSDLAELPKNFEIKDNNYKPANELLQIYNCRNNHFNSYDELSPLMKSSVEGEIGYIPSRYSTILTREYRSGLSSNSHGGYIFIAKLRLWVKEEDLYYFIKHRDQWTKYHSFNTKLSQDPSNTLLQDYSYLMSEQEYENLQYSTDLEHDNPFKKTKKPLELKNSELEKLKHMNESELLQFLNNDDILIQFFNAKEFTSFHESEIMQLTFGKSTAKLMSSAIDFPPIKYEPYLYKLNHDLDTFENKVDRYLALQDAYQQEHNNSPSGSSDNGFMEIEEDLDFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMU8</accession>
    <name>A0A1D8PMU8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C500150CA</name>
        <name evidence="10" type="ordered locus">orf19.5682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710511.1">
        <property type="nucleotide sequence ID" value="XM_705419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMU8"/>
    <dbReference type="SMR" id="A0A1D8PMU8"/>
    <dbReference type="FunCoup" id="A0A1D8PMU8">
        <property type="interactions" value="1215"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMU8"/>
    <dbReference type="GeneID" id="3647872"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500150CA"/>
    <dbReference type="CGD" id="CAL0000179212">
        <property type="gene designation" value="orf19.5682"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00150C_A"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMU8"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000179212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="543" mass="60904" checksum="45AA596358EFF0B9" modified="2017-01-18" version="1">MDSDATNRFVPEYRRTNFKNKGRFQSDELRRRRETHQVDLRKQKREEVLAKRRNYANQGNESEDEEEYNPNANNDENQFYNKLKQDLPKMLEMIQAPDFDSQLAATVKFRQILSREHNPPIDLVIQSGVIPTLVEFMKEDHPDMLQLEAAWALTNIASGDSSQTRVVVEANAVPLFVQLLYSQSLEVKEQAIWALGNVAGDSSDNRDYVLSCNAMEPVLQLFNCTKMSLIRTATWTLSNLCRGKSPQPDWNIVSQAIPTLGKLIYSVDAETLVDACWAVSYLSDGTSEAIQAVIDARIPHRLVELLGHESTLVQTPALRAIGNIVTGSDYQTQIVINAGVLPALAPLLNSTKDTIRKEACWTISNITAGTTDQIQAVIDANLIPQVIRLLIHGDYKTKKEACWAISNASSGGLTKPDQIRYLVSQGCIKPLCDLLSVADSKIIEVTLDSLENILKMGEMDKEARNASVNEYALFIEEAGGMEKIFECQNNPNEKIYQKAFGIIEKYFSDDDGQIDDENIVPESYGNSFGFGMDSNQQQQNFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN25</accession>
    <name>A0A1D8PN25_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C501040WA</name>
        <name evidence="2" type="ordered locus">orf19.9524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <property type="match status" value="1"/>
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            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        <name evidence="13" type="ordered locus">CAALFM_C501650CA</name>
        <name evidence="12" type="ordered locus">orf19.13673</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="MYO1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C5_01650C_A"/>
    <dbReference type="eggNOG" id="KOG0161">
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    <dbReference type="OrthoDB" id="6108017at2759"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin heavy chain, muscle"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinesin motor domain"/>
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        <ligand>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29597.1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="1948" mass="226692" checksum="8E49473AB44A439D" modified="2017-01-18" version="1">MVTSSTANDNNNEDPIISKNWVWVPNQQDLFTKGYITDYLPDGKCKVNVVKGQESSHDSTIIVDQDKLENCNPVKFNKCEDMAELTHLNEPSVVYNLYLRYLDDLIYTYSGLFLVAINPYKSLPIYNQSILMKYHQYNNVTTNKNDYKSKNASNSNNNNKGQSPPHIFAVAESTFRNLLSNKKDQSILVTGESGAGKTENTKKIIQYLSSITSGSHTNKVDHNNSIDTKILQANPILESFGNAKTIKNNNSSRFGKFIQIYFSNTGEISGANINYYLLEKSRVISQSNQERNYHIFYQFLKGYENLPSLGLNKDMSTYNYLSGGKLTINNVDDFKEFNLLVEAFKIMGFTTNKMNFIYQVLAIILHLGNITFTSWKSEQANFTNDSPIDRICELLAVDKDLFVQNLLRPKVKAGREFITKSKKPNEVKFAIDAFAKYLYEKLFQFIITKINEKLDQSHNGDDNTANNNNDNNFFIGVLDIAGFEIFDINSFEQLCINYTNEKLQQFFNHHSFILEQSEYLRENINWEFIDFGQDLQPTIDLIETKQPMGILKLLDEECLMPKSSDASFMEKLSKNFSNTHKKFSENKFKNGFIIHHYAGKVEYNVENWLQKNTDPISESILNLLPDSQNELIADMFINDPHINRPQTNGGGNSKLKTASQKHKDQLKTLMDQLESTEPHFVRCILPNLEKRANKFDKNLVLGQLRCNGVLEGIRITRAGYPNRMMFDEFIQRYSIICDNELSSPQNKTNCEIILKFVKLNPEDFKVGLTKIFFKNGILGKLEIIRDLALKNIFTDLQKVIRGNLTRLVLKQKIKEIQSAQIISRTMVTLDEIKSNSPWMRLFFHVKPLLEDSAKVLDSKKLQENLQTLTVKLKDSEKLTKGLETDNEKLREQMNNLQDEMINITSIAKEKDDKLSQLRLTENKSKHRIETLEIKLKDFEKQNQDLINEHEKLTRRSLELHDKHNAKVEELNSLNKLHDSAQSELSNLKQQLKEITKLKQDHSKELLKFKQMHDKSIEDLNEKVSRLENLNKKLQADLNSSKDVISSEHGKLQNEIMKLKELCSDYERKQKDSQRTIDSLQIQLKKDEDYKSRYESKIEEAREKVTLLKGKVEKKSQEIDQYKSEIKKLKAELASSNTKITQLDQSTKELSSLKSNESKYVAEIESAKQQLSKKIEEYSSIEADYNRLQTELKQMKQTNTEYSTRITELSTKLNQVTEEAKSKEIEKENQPPNPQFMEEFTHMKLKVNEQTASLRKEKFENKKLSEELQMLKERIMNGSLTSMDLTPKRRSLAIGDKSMITNTVDSFNKEIENLKFQLQQEQGNFQRAENYAIELQKKLNKLLTTRGLNTNTDYEKKYNDSQKRITQLETKIGRLLANSGGDYEDHHLDDNDDDWESRSSNGGSGGGSTSSSARNSLVKSESITAFHNMRGVSQDYIQIYQDITKTLKSTREELNGSKTEILRLKALLRESEDELYQVKQENYKTSVHDYEQDLAQLKVKHETLLSRNKDINESLEIYKKRSDEYYKKLELAESAIAISKRHEEQATKEMKESRSQLLLVREELRTTQILIKDFRIKVGNLEATIEEKNHQLDANKEEIKQIQDKLNYHLKNFENKELNEKLKEEIKNLNRDLDFKTDIETKLIKENKKLQLDYEDVLLVKNNLQNEVEELILQEEKLQNKIDELTNNNRQLENEKLINERKIVNCTKQISGLKELVDEISIERDKLLKDKETLQNDLQIMTNKFDSTTTELKQAHGELNFLKKHLENQREDSEAIKTELNQSKMSTSFDIRDQQKLRNELLVTKEENFSLVKTNKELNLKVSDLEEKLYSNEQLKYWESKVDTLSKALDGALNEKHEADKTIKNLQRSIKQLEIRVENESQLSKRYNDENFDYQNKINHYKSTIDIIHNENIEKDLQLKSIQRENIEMKESMLMLQKEVLELRERLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNT2</accession>
    <name>A0A1D8PNT2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromatin modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C503830CA</name>
        <name evidence="7" type="ordered locus">orf19.8708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711163.2">
        <property type="nucleotide sequence ID" value="XM_706071.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNT2"/>
    <dbReference type="SMR" id="A0A1D8PNT2"/>
    <dbReference type="FunCoup" id="A0A1D8PNT2">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNT2"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PNT2"/>
    <dbReference type="GeneID" id="3647227"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503830CA"/>
    <dbReference type="CGD" id="CAL0000191045">
        <property type="gene designation" value="orf19.8708"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03830C_A"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNT2"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000064">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000191045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="231" mass="26010" checksum="8C32DA8CBE6B9353" modified="2017-01-18" version="1">MSVSAPEDIRPSTSNGDQSNRDTNTPATSTSASTTALPPPQPPPQQQQQQQPSSSTTTTDNNNNNQTSQQPQEKKEKIIPRDVRLLHLIFATHAVHNYQDHVPLQLMDFAHRYTKSVLKDALVYNDHSKPINANTNLNSNTNATVNTDDIRLAIAARSNYQFKPVPPKELLLELAQERNSRPLPPVIPRWGLNLPPEKYCLTAKDWDSIYDEPDEDNNQSSQQKNKKLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNV5</accession>
    <name>A0A1D8PNV5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C504050WA</name>
        <name evidence="12" type="ordered locus">orf19.8872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710666.2">
        <property type="nucleotide sequence ID" value="XM_705574.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNV5"/>
    <dbReference type="FunCoup" id="A0A1D8PNV5">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNV5"/>
    <dbReference type="GeneID" id="3647735"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504050WA"/>
    <dbReference type="CGD" id="CAL0000195878">
        <property type="gene designation" value="orf19.8872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04050W_A"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNV5"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="362"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="572"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="705"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="863"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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    </feature>
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000195878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="931" mass="104181" checksum="138D57F03A9C593E" modified="2017-01-18" version="1">MGLVYFLFVYVLGGLTFLPGLVALYFYLAPKSTLSDDNELDEEKPSGELEEKHQSGLEAYKSGWIFVTRDYIESPDEINSNTQSITESNDNKSAYSALYKLVKDSATKKFKDNSQSKKLQPEEKKFLDHDDNDLDELNKDTFALPKDTNSPNPKSYSHHQRHDPQPQHNHQSQNQPQQQIRSSQKKHRYFAVLKHGNLFLYKDQTLKDVKHVIVLAHHFVSIWPRDLTDAQLFTKYSALALINPSKLTDTPFSTNDTFNSTVNTSNGTEISSSTRSSLSSRTTDQQQNSQQQTNNNAPPGTFFIYCENNCDKEDWYFALIRAMKLEKSELPDILNPEKYAETSHFQTKEMINLIQTLYSSEGQLQTKWLNAIIGRWFLAMKNTKHFEDYVYKKLSKKLNKIKKPGFFNQFEITDIQPGKSAPFFTYPKLKEINPDGTVVASCYVTYNGGLSVTIETKVDLTFGTKFTNREVDLVLKITLSKLEGPMLFKLKPPPSGRFWYCYELDPIVNFKIEPLLSSRTLNFNFITNSIEKKFKEAIKESLVYPFWDDIVFFDSSDQLYRAGIWKEPKIDKDETTASEKENTENNQTDNESAGVDEDNSTNKFDDIDAKSELSTSSRSLRNGKFSNTLTDLTKRMKKKSSPSLSNTEDSLSVNTNNTASLSASSATLNKTPSKSDLTASQSPNTNSTLVSSTFKKIGKWYFKDDGSSKKQHDEKLGYTPPEMISSRRAPRKSSSSMTLGSDSTRYTLATEDNKDLPDIESANSTSASVSNTATTAPSSELSNKGTTTTAPVNVISLSNNSTIPSVAVGADATTTAPAPVANSKLTSTPLDNQTPSYNFSRLDNNNEDLSIFSVAYQNAAQIIPSSTPPPLPPRDISDNLSIRSGSLVGEPTISLSQPNSPIRTKTLTRKPPPPKSPLLHAHSPNQDIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNW1</accession>
    <name>A0A1D8PNW1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucan endo-1\3-beta-D-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">SCW11</name>
        <name evidence="11" type="ordered locus">CAALFM_C504110WA</name>
        <name evidence="10" type="ordered locus">orf19.11374</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721805.2">
        <property type="nucleotide sequence ID" value="XM_716712.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNW1"/>
    <dbReference type="SMR" id="A0A1D8PNW1"/>
    <dbReference type="STRING" id="237561.A0A1D8PNW1"/>
    <dbReference type="GeneID" id="3636521"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504110WA"/>
    <dbReference type="CGD" id="CAL0000194867">
        <property type="gene designation" value="SCW11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04110W_A"/>
    <dbReference type="eggNOG" id="ENOG502QS0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNW1"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000160">
        <property type="entry name" value="Probable beta-glucosidase btgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111192" evidence="9">
        <location>
            <begin position="18"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000194867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="506" mass="54382" checksum="39D1EB2A378D3BEB" modified="2017-01-18" version="1">MFSNIISTLALLQLLNAAPILLTRYHVAAPTTEIKTVTTGTTTVWLPPVGIYISDGQTSTSTITDAQWNTYPVTFTSIINKDQAAPTQQTTEAQQQQPTTTTTSSTSPAQPTTTETQQQQQQQQQPTTTEQAQPTTTEQQPQQPTTTEQQQQQQPTTTEQAQPTTTSTEQAPQSTEQGQQQGQPTTTEQTSQTTEQGQQTTEQNDTTTQSPSTTTIDYTSSTSSTSTSSPSPSSSTGSSGDIPAPTAIVYSPYANDRSCKSADTIRSDIQLINSKGIKQIRSYGTDCGSLTTVLETCRELGITVNQGVWISAAGVDSIDDQVSDVIKYGQSNGWDVFNLLTIGNEAIIAGYVSPSELVSKIKSVKSQLQSAGYNGKVTTSEPPATYLKYPSFCTDADIDVVGINPHSYFNANIEPKDAGSYIVHQQQQVAEICGGKSVLITETGYPSKGSTLGVNVPSPENQEIAISSIIKETGGDCTILTTYNDFWKDPGPYGIEQYFGVIQLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP89</accession>
    <name>A0A1D8PP89_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Est1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">EST1</name>
        <name evidence="4" type="ordered locus">CAALFM_C505470WA</name>
        <name evidence="3" type="ordered locus">orf19.11527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721953.2">
        <property type="nucleotide sequence ID" value="XM_716860.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP89"/>
    <dbReference type="SMR" id="A0A1D8PP89"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG2162">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
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        <property type="entry name" value="Est1/Ebs1-like"/>
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        <property type="entry name" value="TPR-like"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="94"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="1">
        <location>
            <begin position="260"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000174640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="612" mass="71841" checksum="7343D45BB00B2BDD" modified="2017-01-18" version="1">MFAGSVCVIYKSVTTKKNFFLFLFTNSYALAMAYTDEIQLYKTKLDDILAKKYIDQSLLVGFTASLQAKFYGWIVADLDRYHHNLGLPFRTIDLFETLWADFHSPIIKFFQHQHAVVFEEINNNLKECQREGKPGSFKVKPVEMRKINDSFIKFIKDVFGFYSKLLKYFVTHYRNSYLPKKFMESFNFTVEKSAVYCADDNFQANVLYLVHRCCLSLGDIHRHRTFIETSFVTPASSNREYFRIRSSTDKTFLFPAYSKALQYYHLCIMLLPALNEPYNHIGVIYNLVDEKFTAVYWFLRSQFTRIPDYKLGLANLTKLLQKHWFTTALVDIVKSTPERRFSNTRIMNVYLVCLIGYIYCPEKYKSGPNIVKKISFSKIETDFFKMLDKNFEEEVVLQQLVVAFSFLKLDGQEKLVKFTFRFVERVLGCLKTQESLVILRFLLNVLRENQEFLKVFQSRKKCVVYLCAVLNKYYQEVSHRPTRAYYFWEDVHFRDFSLIKYQFKDFRDDGIFEANDIDVLVGDYAGDRSNENDLRAKAVLVLGKKILGGAEGYEVKEADKLSIKRRDQAVVVPQSLEEIQSLISNQAKELCMDIDQGMQNMVDKLVEDDPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPB3</accession>
    <name>A0A1D8PPB3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication ATP-dependent helicase/nuclease DNA2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28 29" type="primary">DNA2</name>
        <name evidence="29" type="ordered locus">CAALFM_C600320CA</name>
        <name evidence="28" type="ordered locus">orf19.8783</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="29 30" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="30">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="29 30" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22 31">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712310.2">
        <property type="nucleotide sequence ID" value="XM_707217.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPB3"/>
    <dbReference type="SMR" id="A0A1D8PPB3"/>
    <dbReference type="FunCoup" id="A0A1D8PPB3">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPB3"/>
    <dbReference type="GeneID" id="3646072"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600320CA"/>
    <dbReference type="CGD" id="CAL0000193143">
        <property type="gene designation" value="DNA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00320C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPB3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032448">
        <property type="term" value="F:DNA hairpin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061849">
        <property type="term" value="F:telomeric G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 29" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="25">
        <location>
            <begin position="404"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="DUF83" evidence="24">
        <location>
            <begin position="613"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="967"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="1072"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="27">
        <location>
            <begin position="1145"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="CGD" id="CAL0000193143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="AOW29981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1426" mass="163436" checksum="49DEA648C291B4EB" modified="2017-01-18" version="1">MSGINEDASSTTKRFKDSNEAIKPVKRLKKTTYFPVNNLTNPQTNQSNIQKSPIRPIDINSITTKVNPVQEINRNNTDNLTKVQKQSELNFLQENSDDSFDGIRWKESPEIKGSHKQMEIKNSFGGLPSSPLKNINPESENVDDRTSDVLNRYGSDFENVSKRRTPLMSKTRSDITSSSSNHKKQTNEISQLQRAKSGDVLKVKSISGSITDSFQNTLNNWINKFETDPQDDQNPNSLPDTVEMNKTIPKISTPPNPNTSIQSEDPFSDDDDLIQLLHSKTLPECPQSQPVSNDNTSIKPPMENASDDGESSDDPFTDDDSELMEVLKTQTPSVTSAFTKSFQRGIQNFEKLNIENKYEEQDIEKVSDLIYDRVTTQRFRIVNIIEQYYGPKSEKQLILEVVNSSRDKSKLVVRGEYCELELEKGDVIHVIITDSARPTLVDDMHNLLIWNPDIMLSATTISQQLNCSRKTVILSRYKFPGTSTIPIIVGEIVHFIFQECICTERWDMEFMSQVLDQLLSQYMLAIFGIGKELKDVRDEVVKHFDYLETWFKTYYKQPLSKKNLIDETSEKEQIMFAVEEALDIEEEIGSPIFGIKGKIDATITAKFENKKLKGQYMIPMEIKTGKEYIYHHAQASLYSLLFKDRYDKNIDSYLLVYTKEKVTKKCNIRISELRSLVNLRNRVSNYIKDNLKLPPLVKNSNCDRCEIRSACMTLNHLTENGTKEESGIEEELYEAITRDIFENDSYRKYFQHWDELISKEEDVMGRAVKELWTIPAEDQEFQGKCFSGMTITNSNETESNNFLFSSTHHDKSQDQQFVYTFAKAENPSRFNLAKSQVTINDKVIISDEEGHFALTTGYVKQITKDFVVVSTRRKIITSDYKLKNYNKANNQVFQSVIRSTQQNIRTTTKKRFRIDKDRMFYGLGLARYNVLSLFLPNGASQLRKLVVDLEKPTFTASSWEIPDAETFNPDQIAALKKVFSADDYSLIVGMPGTGKTTVIAQLIKVLVAQRKSVLLTSYTNSAVDNILLKLKDLDIEFLRIGYPQRVHKDIKDYIPEFKDSITTYEQYVNTYMRPKVVATTCLSITDVCFNLRYSFDYCIVDEASQITLPVSLGPLRFAKKFVMVGDHDQLQPLVTHPDKRVKQELSRSLFSLLAKEHPDSVSHLTYQYRMNSDIMNVCNTLIYNNKLKCGSEQVAQNSLKIPHPEVLNSFIGEDVSPDSQWIHKIFDEKNNVLFLDYDAVPAVEENVGEMVINTKEALLIQQIVNALVHGGVKEDEIGVMSFYRAQLSVLKKNLNNLKDLEILTADQYQGRDKECIIISLVRSNERKFAGDLMKEYRRLNVATTRAKTKLIILGSRFTLSTNELTKTFIDYLENEKWYYPLPKSAHKIYKIPEVNGPSPTRSQKSQDSPILNRNPILKNVVQDITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPH7</accession>
    <name>A0A1D8PPH7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C600890WA</name>
        <name evidence="9" type="ordered locus">orf19.7736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709206.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PPH7"/>
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        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPH7"/>
    <dbReference type="GeneID" id="3644028"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600890WA"/>
    <dbReference type="CGD" id="CAL0000189188">
        <property type="gene designation" value="orf19.7736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00890W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPH7"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="420"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000189188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="754" mass="84955" checksum="DA2FEBA46C52D6BB" modified="2017-01-18" version="1">MPDLTPLDNDEEDAWSYSFPPSTESLPISQQSQSKRSTTQPSNSTFRTWQNGDTSSTNSQMKLSIDTTTTSSKSSLPFPSTIQKSIPLDPLTTKEDANSVISKDSKGNALNEASQTDDKPKFMKDLEEYGSTRNISNSPLSQQSTNGTNLLSSPKFISYRKSKRTVSEGTFDSMLDKSPMSPPASRYDPKLYVDEFYKTSKFRYATIKRNIDFHNNFHSLDLTDRLVDDFACALSREILLQGRIYLSESYICFNSNLLGWVTNLVIQLEEVVKIEKRSTAGLFPNAISIETVDGTLHTFASFLSRDQTYELMSTLWKGKTGKSNNDSTLTSEDELENNAIDSPNKNIESYILSLDGDDEEDNDVQSLDNSGEDEEEEESELDIEEVLSTKLIKLKSESPYTNNGPDAHAPTTANYEKLEAEIELVDEVIDAPMGIVFAILFGPYTKFQTNFLETHDGSEISEISDFRPSEEDPAVLERKYIYRRALGYSIGPKSTKCEVTETIEHLNFADYIVVVSTTVTPDVPSGGVFSVKTRYVFSWANENHTNLLIYHHVEWTGRSWMKSVIEKSSLSGSTATTKELIKELKEEIVKQTYFIDGPPAIKQPAKKKVKKVEPEVKNEPKAEIKASTVDVSSYLQQNITTAFFILFTIVTIILFMQIRLYGLLRKSNSIAETQLLLTLQLTDLQQKPQVEVQDNVFWNLIHSKLGRKLTSLEKLQFLTYQLQAIHKEKTDDSGGAGNTNRLIDSIPKYIRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPQ0</accession>
    <name>A0A1D8PPQ0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fpg1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">FPG1</name>
        <name evidence="12" type="ordered locus">CAALFM_C601820CA</name>
        <name evidence="11" type="ordered locus">orf19.10905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331003.1">
        <property type="nucleotide sequence ID" value="XM_019475458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPQ0"/>
    <dbReference type="SMR" id="A0A1D8PPQ0"/>
    <dbReference type="STRING" id="237561.A0A1D8PPQ0"/>
    <dbReference type="GeneID" id="3641632"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601820CA"/>
    <dbReference type="CGD" id="CAL0000181241">
        <property type="gene designation" value="FPG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01820C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPQ0"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="10">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000181241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="372" mass="42809" checksum="EFE62A95A65CE8F8" modified="2017-01-18" version="1">MPEVAEVSHVCALLKRNILGFRITKVNLLHDPLLFPVLKNTNDAEKELNKMRKVLTNAVVTSVGRHGKYFWIRLNNHNTTNVLLMHFGMTGMIKLRNVHSHLAFMENGGDKKALEKLERFRYKDSRIKPDVEVKQEWPPRFTKFNMELENNDKKLEFAFSDPRRLARVRLLSGLEVSTDESLLKLSPLNALGPDYSKPEVPPKESEPFVFGDPDSDNHGRARLSIDEFSALILSKKKPIKSLLLDQTYFAGVGNWVADEVLFQAHIHPNEILSSKISKDLEYVHPVIQQLYDSLIYVCEEAVRVEGDVAKFPDDWLMLHRWGKGRKEKRKTPNGYILDHITVGGRTSCYCPELQRLIKVETATTTKRRKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPS8</accession>
    <name>A0A1D8PPS8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C602140WA</name>
        <name evidence="2" type="ordered locus">orf19.10957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712493.2">
        <property type="nucleotide sequence ID" value="XM_707400.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPS8"/>
    <dbReference type="GeneID" id="3645886"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602140WA"/>
    <dbReference type="CGD" id="CAL0000196074">
        <property type="gene designation" value="orf19.10957"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02140W_A"/>
    <dbReference type="eggNOG" id="ENOG502R1XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPS8"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000196074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="111188" checksum="2CE77F9ABDAD9A95" modified="2017-01-18" version="1">MSTNSTSDRFPNSYWSIDYVTGLNNLKSQSFKSLKQLHELRKLVFNYMTYYHANSEFLNKSSIDLFPVESTFLPFEYNPRSVSNTPTTSPYRKRIVSNETTVSKQETITPKHETTMTTAYSEYIDYMSQESTILLNLTSIIDRDVLQDITMYLKYHEPKIHQQFTRLDEVYNNYLKSYKNIERLKSRHIEQLRLKEFSQSQVEQTKSSPEETVEDQSQHSSSFEESYADEDLEDEEIDNTFDLSFPLHIGTVVVSSAEELQLIMNQLITKVPITMRKIPLPGYKNEIFNSESISKVLLTIPIKGFKPSRLNIEKFGQGLLDLKLMTSSNFFNKKFKSEGMWFEWSDLAVYFAQFKSSSAASSVKDTSSIGSNTTSTTNKSSAISSPKNGRSKFISDMAETTTRFNAMFNNVRSSILKTNHAEILEDIEDSYNEEILNLQEFKYLLENGLFDLSQYLEKFEKMKIEIIYKSLSRLSEILLKFQKEQTTKLEAFSNNFIRNINKSENYLHDFNKTMEHFSTGIYFPSVITPDTNVRSTSIGTNYQNLKYQFDLYKDIPLQLQNNFNSDNESLLSIASIPYILYQTIKIIEERSNDNVEVVRKLWMAPIEYQSQWRIKQDIIQLVADYTPDLKNDISNKYLIEQEFCNQVLKHLKAQKTNDVIIFVKNWLLEISDSIIPFVIFDSLMNLYNQENVAAADLIKLLSTIPRSNLASLIYVIEYFGNLFALGSIPNYEISDELPEESLLESIEEASIVQVSNELNSMDTIGSIPIMHLILRPSTSKNSTGFKPPLDKYKRIMVDILKLDVRTELLKHLIEHEINYKSKKEAEKLQVKKIPVPVPVPVPVSESESPQTPPQAKVDSIDRSTPAIVHPQPTQPNKQKRPESAEFTLRPFRTRPTPVPSPQSSPKRGAFPTFTGSLSSGASTTKSPTPPLSQPTTTNQLLPAASHHTNRGRSLSNSFITPRIEIEFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPY4</accession>
    <name>A0A1D8PPY4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asg7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">ASG7</name>
        <name evidence="3" type="ordered locus">CAALFM_C602510CA</name>
        <name evidence="2" type="ordered locus">orf19.12966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719085.1">
        <property type="nucleotide sequence ID" value="XM_713992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPY4"/>
    <dbReference type="STRING" id="237561.A0A1D8PPY4"/>
    <dbReference type="GeneID" id="3639173"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602510CA"/>
    <dbReference type="CGD" id="CAL0000198453">
        <property type="gene designation" value="ASG7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02510C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPY4"/>
    <dbReference type="OMA" id="YFTNSEP"/>
    <dbReference type="OrthoDB" id="4014450at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000198453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="148" mass="17067" checksum="6338FDF8F778E06A" modified="2017-01-18" version="1">MKIQKVNNRVKQLETPIDYNYDSLKACKCDSCDYWSILSPSQSSSLFLGILIPIIWLINLFRIINCLYFTNSEPLAATAYLQIFKTKVRMKSNVPLTSHYIEYHNNNRVEMYSCLGHILAAMMVYGLVLFAIVMAFAKSTRVVIWPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQF0</accession>
    <name>A0A1D8PQF0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C604370WA</name>
        <name evidence="10" type="ordered locus">orf19.8698</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712108.2">
        <property type="nucleotide sequence ID" value="XM_707015.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQF0"/>
    <dbReference type="SMR" id="A0A1D8PQF0"/>
    <dbReference type="GeneID" id="3646294"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604370WA"/>
    <dbReference type="CGD" id="CAL0000193876">
        <property type="gene designation" value="orf19.8698"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04370W_A"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQF0"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000024">
        <property type="entry name" value="Voltage-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000193876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="99085" checksum="66B6D3475A507280" modified="2017-01-18" version="1">MSGLDRGANTATTTTTSSSSTTSSSSYSITYSTNEIPILTYSNNNNNNSPHIHQSSEVHETSHHSQYEENTFIDWSKESIIISRNPSVFLTNKWIILIFSAIILGYFTSAIDLIQVSLNDFKKGICFSSKDSWTLLNPYMTCPVEDWYNWDQIFFTIRNPIVKFIINFPIYLILALAFGIIAGYLTYNRAYMIRQSGIPEIKLIISGFNLKIDQYLGFKTLLSKSIALIFVVSSGLWLGKEGPLVHISCCVFNIIYEIISKYYSNQNEAIRRELLTAATATGISVAFNSPIGGVLFVLESMPSYFIPTRIMWNSFVSATVATIILTGFKIFTDGRNFNEQVLFQVNFGNFSWLFVEIIPFIMLGIMGGVYGHYFIKFNGKFSNIKIRSLIRHRLCNLLKVDYKYGSILEILLIVLITTIINFPFEISKLPLNALLNLLFKSCTKDNDNSNLSTSKDFICQDSNGVALFKLLYIMIEGFWLTCYTFGLDLPGGILMPSLVMGAMTGRFLGIITQAIQSKFNWESLATCTADSCLVSPSSYAVIGAASFMTGVTKLTMSVVVIMFEMTGAVTYVLPIMGGVMTSKFVSDWLTPNNIYDTWLQNNFNQSSDGVEGVTTNNHLNSNFYDNGNQLINQGKGTGLISFQNLTSTIKSKLPNINIASSMIPLLDVKCLCLLPDQEQEQFTLNSLNSFINNDCHEGYPMIINYNNPIIVGYIPKSQLLNQLFLSLSNREIDSNSPISFQINHGVDIPERVEQLLSQRKQPQVVSINVHPIQSTLIINEKTPILLIIEMFEKLHLNSLIIVSNQDETSMTGFIDRFILNDLIIDKFEKLVDKLNDYQVIQQFDIEENAGRVEMTEFDYDNDEDDDMTRIDRKSIELIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQI4</accession>
    <name>A0A1D8PQI4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 14">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 14">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAALFM_C700150WA</name>
        <name evidence="18" type="ordered locus">orf19.7108</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000193449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="617" mass="70363" checksum="072CA35A747572C4" modified="2017-01-18" version="1">MITQSRISNLAKPILAFLFILTLYSILFRKSDDGADKILEPHGYAVDNEEDPLFLKQQFMQHGLSNNNNNKKAGGKDANTNKLQPDKAIVIDKTFLDQMDKKTHKCPDYVVYSQKRHPPFSIGRFKYPYMRPAPKCRTFVSTAVESVIEDLKSKIEDPDLARLLENCLPNTLDTTILWHQPKIKTARQDALLPQSFIVTGDIHAEWLRDAARQLSVYQPMVRFDPKLKELILGAINTQAYYIINSPYCNAFHPPPGSGVKRGDTAFDQVHPKPDWKQVFECKYELDSLASFLTLTNEYYENSKGDTSFINSSWLKAFEKVLIILHRESVPSFDQETGQMLPFYYSFQRNTNIGSETLPLGGVGNPVNYGTGLIRSAFRPSDDATILQFFIPANIHMLTELKRARNTYLTNENIARDTMLVETADTFINALSTGIEKYGIVNHPIYGKVYAYEVDGYGSATFMDDANIPSLLSIPDLGYTKIDDEIYQNTRKMILSKQGNPYYLKGHFFEGIGGPHIGIRNAWPMSLLMRIRTTDDDDEIISSLEMIMRTTANLGLMHESVNVNSRQGRDYTRSWFAWCNSEFGTTILHLAKNKPHLIFKKEWQNVPYDIESVLSQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRY0</accession>
    <name>A0A1D8PRY0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial 37S ribosomal protein MRPS28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_CR01370CA</name>
        <name evidence="5" type="ordered locus">orf19.10056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718188.1">
        <property type="nucleotide sequence ID" value="XM_713095.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRY0"/>
    <dbReference type="SMR" id="A0A1D8PRY0"/>
    <dbReference type="FunCoup" id="A0A1D8PRY0">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRY0"/>
    <dbReference type="GeneID" id="3640168"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01370CA"/>
    <dbReference type="CGD" id="CAL0000201890">
        <property type="gene designation" value="orf19.10056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01370C_A"/>
    <dbReference type="eggNOG" id="KOG2815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRY0"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000201890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="320" mass="37021" checksum="98BFA3153B704815" modified="2017-01-18" version="1">MFKFTTRFLSTSRSLLSQAGESTSSASATIPRFHVKFGAKQFIEPGTNKRRAKRLRRKETRIKKQIIRDVNTLKQHEVKNVSLKVDPVLGDPNCGFVERIMKKVENQELTLAYGIDRVEFEKLLYAAEKLSLENASKNEALRESVIQTEENKRKAVMTILNLKNTNVPDKKKMAIKFAREEMQRSPGDTASPEVQAAIATIKIHYGMQQVKNMPKDKINIQGVRKLVQYRQTILKYLKRKNPESYYYTIAKLGLTDDVIVREFNMGKQYMQDFKVWGDKVLVKETNSVAKKNKKIKDLKDRVAKYNELAKKNYEIMYGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS25</accession>
    <name>A0A1D8PS25_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_CR01790CA</name>
        <name evidence="7" type="ordered locus">orf19.10111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718245.2">
        <property type="nucleotide sequence ID" value="XM_713152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS25"/>
    <dbReference type="SMR" id="A0A1D8PS25"/>
    <dbReference type="FunCoup" id="A0A1D8PS25">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS25"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PS25"/>
    <dbReference type="GeneID" id="3640161"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01790CA"/>
    <dbReference type="CGD" id="CAL0000197996">
        <property type="gene designation" value="orf19.10111"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01790C_A"/>
    <dbReference type="eggNOG" id="KOG0220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS25"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990391">
        <property type="term" value="C:DNA repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062128">
        <property type="term" value="C:MutSgamma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062037">
        <property type="term" value="F:D-loop DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03282">
        <property type="entry name" value="ABC_MSH4_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004070">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA repair protein MutS, domain III"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="630"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="803" mass="90732" checksum="431D019D496548E3" modified="2017-01-18" version="1">MALASQLSVTDDSAYGFITINAEIVSKKRKLAQNDDRFEVVMSVYSPKADSMDVGVSVLKLKTLELTLMSFCDSSTFVRTVNQIQVYEPTSIILPEAQSHSQIEKLKYIIHSNISDKVRERFMKAKVFNAFDGMNSLKLYTDINESTLGQVISNRKLSLAAANACIDYCVSTKMFRVTNKIRLKYCMCENTMLIDTCTVRDLELVDSLSETGTTLYSFLNCCLTKMGMRILRTSILQPSTHENSIILRSESVQELINDEDALISIRSSLKHTCDLEKVFSTFLEPRGLLSQEQEINNIILLKTVLQNTFVIRKSIQNVSSHLLVQVKQILEHENVQHLLAIINEYIRNDCQWANNSTELANQRANAVKSGVNGLLDVSRRIRETLLEEVSELVAKLSEELEIFMEYRFEISRGFFIKIKGNNTDINSLPEVLINRVKKRKTIECTTIELMKQSSRYNDIVSEITTLNSTIIHDMYTSINSYTPILLMVSEAIGTLDLLCSFAYFTSLQKDSYTCPEFAKEVTIMRSLHPILGGNNSNFVANNYSCNHELSRIHVITGANMSGKSVYLRQIAYLVIMAQMGCFVPAEYARMRIFNSLYSRISSDNVDINASSFSKEMSETAVILNDSDGDSLILIDELGRGSSLTDGFSICLAILEDLICKEATVITTTHFRDIAQVLANKSCVVTAHMQTVETNGQLEMKYNLVLGRNGIVGYGIRFAEVSNLLPQELIEDSKVVANILRSRKPVHGDKELKLLSRRRKLVLELYFALNYIPKLNCDMNYKIQLLQTLQSKFVEEINITPNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTM6</accession>
    <name>A0A1D8PTM6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fgr32p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">FGR32</name>
        <name evidence="4" type="ordered locus">CAALFM_CR08030CA</name>
        <name evidence="3" type="ordered locus">orf19.8225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714220.2">
        <property type="nucleotide sequence ID" value="XM_709127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTM6"/>
    <dbReference type="SMR" id="A0A1D8PTM6"/>
    <dbReference type="FunCoup" id="A0A1D8PTM6">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTM6"/>
    <dbReference type="GeneID" id="3644136"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08030CA"/>
    <dbReference type="CGD" id="CAL0000183213">
        <property type="gene designation" value="FGR32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08030C_A"/>
    <dbReference type="eggNOG" id="KOG0431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTM6"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:clathrin binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:clathrin coat disassembly"/>
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    </dbReference>
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        <property type="term" value="P:clathrin-dependent endocytosis"/>
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000183213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW31488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="773" mass="86372" checksum="96C3457C20F7D40E" modified="2017-01-18" version="1">MVPPKKDAFADLFQSASSGNSTSSLNLKLNNLSLSERQKLQQQQQQQQRQQAFQQPTKNNLLQSQSQNNSVNSSWSNIDILTPSRTASPVSNSGNSESGVSLHQTGILSAQPEDPFSIFLESKSQNSSSKSDPTPVNRDNSKSAEISLLDDDFTDFFQESKSASKSVASPSISSQTSEAESHSTVSHSKRASNRANEQKDFVVAELVDIGFSVEDANEAINKRGLDLQKCVNYIMSKNSGNSNTDMVENGGSVLGQRSEGIKLNELGTDLVKKANSFYNFSKRAVMQNLEQFSGPRSNNDNIPAWMKTKEKYESDAMEKKYGGEEYGTDEENINQKDIERFMKQQRERNRDRSRARFENWIDGKPKQSHPSSKESSPELPQRPSNSNRHGIMSSQKREPPRRNVQQKASIELPQRPARKSQVTAPPERPTSINHHASDPVSVDSSVNSTTPDEDLLGLGTSGTSNGRNAPAPGSFRDSSPLNQFVYTDYTTAKEKATAAYKSGDYTTALESYTICLGCLPPNHELRIVILSNLASVNKLSGHLKESLDNIKDAEALFLPQEILSDYEIADKSIKYWCTKLFMIKAEVLELLEKYSEALEQYLVLIRQLNCNDKKVMDGKRRVDKIVNPQNYKPPKPSVSSRASTPSNKTPAVETKRPTKSGDDEVDALTKDKIEDKIRSWADAKQNNLRAMLTNLNEIIPPNIRMSEKLRNLTTNDLMLPKQVKIQYMKVISSIHPDKLASQTKDNRESGLICNGVFITLNKRWEAFKQEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTT8</accession>
    <name>A0A1D8PTT8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR08830WA</name>
        <name evidence="2" type="ordered locus">orf19.7279.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331111.1">
        <property type="nucleotide sequence ID" value="XM_019475566.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30515450"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08830WA"/>
    <dbReference type="CGD" id="CAL0000188922">
        <property type="gene designation" value="orf19.7279.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08830W_A"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000188922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="87" mass="9544" checksum="CB742D4F2B89314C" modified="2017-01-18" version="1">MVTRRIFQVAQFKTASRHWLPVNSRAYFSSRQRAVNFNNISEGGLIANDDVFSSPVSATAAAEETETFEPTVHSSDDVITAGPVNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTZ9</accession>
    <name>A0A1D8PTZ9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR09500CA</name>
        <name evidence="1" type="ordered locus">orf19.7345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716479.1">
        <property type="nucleotide sequence ID" value="XM_711386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTZ9"/>
    <dbReference type="SMR" id="A0A1D8PTZ9"/>
    <dbReference type="FunCoup" id="A0A1D8PTZ9">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTZ9"/>
    <dbReference type="GeneID" id="3641897"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09500CA"/>
    <dbReference type="CGD" id="CAL0000195559">
        <property type="gene designation" value="orf19.7345"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09500C_A"/>
    <dbReference type="eggNOG" id="KOG2878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTZ9"/>
    <dbReference type="OMA" id="TEYVYGW"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000195559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="334" mass="38993" checksum="59FBDB2BCB05E9A9" modified="2017-01-18" version="1">MDDTLTISIDFIDDQIQQYDFNEPLIIGISGPQGSGKSYLTNQLYNYLQTKYHPNLKTIQFSMDDFYLCKSDQDKLNDSTENPLLKGRGLPGTHELSLLVDTFNKLINNYKQFKKSHLESESESESDWEVIKIPSYDKGAFNGIGDRSNDKYHTLIESPIDIIIFEGWFNGFYSLDPTILQLKYLTSSPSPSPTPTPENNNNHISLQSFKLYDLQEINKNLQNYESLIWSFFRISIIFQTDQINNVYPWRLQQEHELIAKQQQQQQQQKSVEGTCDQVGMKNDDEIIKFIDRYMPIYLLYYENLCDYGIKHCKNLIISIDSNRRVIKNRVLNNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>O94030</accession>
    <accession>A0A1D8PCV5</accession>
    <accession>Q5AI77</accession>
    <name>MIA40_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MIA40</name>
        <name type="synonym">TIM40</name>
        <name type="ordered locus">CAALFM_C102880CA</name>
        <name type="ORF">Ca49C10.16</name>
        <name type="ORF">CaO19.10494</name>
        <name type="ORF">CaO19.2977</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Cu(2+) or Zn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.</text>
    </comment>
    <dbReference type="EMBL" id="AL033497">
        <property type="protein sequence ID" value="CAA21980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T52160">
        <property type="entry name" value="T52160"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721476.1">
        <property type="nucleotide sequence ID" value="XM_716383.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O94030"/>
    <dbReference type="SMR" id="O94030"/>
    <dbReference type="STRING" id="237561.O94030"/>
    <dbReference type="EnsemblFungi" id="C1_02880C_A-T">
        <property type="protein sequence ID" value="C1_02880C_A-T-p1"/>
        <property type="gene ID" value="C1_02880C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636866"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102880CA"/>
    <dbReference type="CGD" id="CAL0000191454">
        <property type="gene designation" value="MIA40"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02880C_A"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054990_1_0_1"/>
    <dbReference type="InParanoid" id="O94030"/>
    <dbReference type="OMA" id="CFKRYPE"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="PRO" id="PR:O94030"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000235285" description="Mitochondrial intermembrane space import and assembly protein 40">
        <location>
            <begin position="32"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="55"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 1" evidence="3">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 2" evidence="3">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21980." evidence="5" ref="1">
        <original>LS</original>
        <variation>FF</variation>
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21980." evidence="5" ref="1">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21980." evidence="5" ref="1">
        <original>N</original>
        <variation>D</variation>
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21980." evidence="5" ref="1">
        <original>P</original>
        <variation>T</variation>
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="252" mass="27930" checksum="8036370CBEB316A8" modified="2006-05-16" version="2" precursor="true">MYRTISRSSSGLIRQSTARLTRQLSTTRTTPSQYNSKLLLGVLGTGALAFGYFSQQSSLIQNASTAENIEKVFEEGNAVAKDAQESLDARQEKVIKENEQKTKKAEDAKTSSESKANVADKKSNSQPEGEPEGEGKQEAAFNPDTGEINWDCPCLGGMAHGPCGEEFKEAFSCFVFSETEPKGIDCIKKFENMRSCFKRYPEHYKDELYDDGEEEASTEVVEHVVLETSEPAIEQIEQGIKEDKVKPNTKSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>P0CY19</accession>
    <accession>A0A1D8PCH6</accession>
    <accession>P43058</accession>
    <accession>Q5A912</accession>
    <name>DUT_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DUT1</name>
        <name type="ordered locus">CAALFM_C101330CA</name>
        <name type="ORF">CaO19.10832</name>
        <name type="ORF">CaO19.3322</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:10249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S51498">
        <property type="entry name" value="S51498"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718145.1">
        <property type="nucleotide sequence ID" value="XM_713052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CY19"/>
    <dbReference type="SMR" id="P0CY19"/>
    <dbReference type="FunCoup" id="P0CY19">
        <property type="interactions" value="1216"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P0CY19"/>
    <dbReference type="EnsemblFungi" id="C1_01330C_A-T">
        <property type="protein sequence ID" value="C1_01330C_A-T-p1"/>
        <property type="gene ID" value="C1_01330C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640188"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101330CA"/>
    <dbReference type="CGD" id="CAL0000195525">
        <property type="gene designation" value="DUT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01330C_A"/>
    <dbReference type="eggNOG" id="KOG3370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_2_1_1"/>
    <dbReference type="InParanoid" id="P0CY19"/>
    <dbReference type="OMA" id="RSGMGHK"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="PRO" id="PR:P0CY19"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035863">
        <property type="term" value="P:dITP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000007">
        <property type="entry name" value="dUTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182930" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P33317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="159" mass="16945" checksum="982C016F1D31013A" modified="2011-10-19" version="1">MTSEDQSLKKQKLESTQSLKVYLRSPKGKVPTKGSALAAGYDLYSAEAATIPAHGQGLVSTDISIIVPIGTYGRVAPRSGLAVKHGISTGAGVIDADYRGEVKVVLFNHSEKDFEIKEGDRIAQLVLEQIVNADIKEISLEELDNTERGEGGFGSTGKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2026-01-28" version="170" xmlns="https://uniprot.org/uniprot">
    <accession>P30575</accession>
    <accession>A0A1D8PEA6</accession>
    <accession>Q59QC3</accession>
    <name>ENO1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Enolase 1</fullName>
            <ecNumber evidence="2">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ENO1</name>
        <name type="ordered locus">CAALFM_C108500CA</name>
        <name type="ORF">CaO19.395</name>
        <name type="ORF">CaO19.8025</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="2632" last="2639">
            <title>Molecular cloning and characterization of the Candida albicans enolase gene.</title>
            <authorList>
                <person name="Mason A.B."/>
                <person name="Buckley H.R."/>
                <person name="Gorman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="8478328"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 64385 / 1001</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Bacteriol." volume="174" first="6789" last="6799">
            <title>Molecular cloning of cDNA and analysis of protein secondary structure of Candida albicans enolase, an abundant, immunodominant glycolytic enzyme.</title>
            <authorList>
                <person name="Sundstrom P."/>
                <person name="Aliaga G.R."/>
            </authorList>
            <dbReference type="PubMed" id="1400228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1993" name="FEMS Microbiol. Lett." volume="111" first="101" last="107">
            <title>Cloning and nucleotide sequence analysis of the Candida albicans enolase gene.</title>
            <authorList>
                <person name="Franklyn K.M."/>
                <person name="Warmington J.R."/>
            </authorList>
            <dbReference type="PubMed" id="8359671"/>
            <dbReference type="DOI" id="10.1016/0378-1097(93)90189-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>KEMH5</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text>Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="L04943">
        <property type="protein sequence ID" value="AAB46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M93712">
        <property type="protein sequence ID" value="AAA34341.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L10290">
        <property type="protein sequence ID" value="AAA71939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="A40624"/>
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    <dbReference type="RefSeq" id="XP_711883.1">
        <property type="nucleotide sequence ID" value="XM_706790.2"/>
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    <dbReference type="PDB" id="7V67">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/C/D=1-440"/>
    </dbReference>
    <dbReference type="PDB" id="7VRD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B/C/D=2-440"/>
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    <dbReference type="PDBsum" id="7V67"/>
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        <property type="interactions" value="5"/>
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    <dbReference type="FunCoup" id="P30575">
        <property type="interactions" value="1259"/>
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    <dbReference type="STRING" id="237561.P30575"/>
    <dbReference type="Allergome" id="785">
        <property type="allergen name" value="Cand a Enolase"/>
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        <property type="type" value="Curated"/>
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    <dbReference type="MoonProt" id="P30575"/>
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        <property type="antibodies" value="3 sequenced antibodies"/>
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        <property type="protein sequence ID" value="C1_08500C_A-T-p1"/>
        <property type="gene ID" value="C1_08500C_A"/>
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    <dbReference type="GeneID" id="3646493"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108500CA"/>
    <dbReference type="CGD" id="CAL0000185645">
        <property type="gene designation" value="ENO1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_08500C_A"/>
    <dbReference type="eggNOG" id="KOG2670">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
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    <dbReference type="OMA" id="RCMMSHR"/>
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        <property type="reaction ID" value="UER00187"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
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    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="CAFA"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
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        <property type="term" value="C:fungal biofilm matrix"/>
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        <property type="term" value="C:fungal-type cell wall"/>
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        <property type="term" value="C:hyphal cell wall"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030985">
        <property type="term" value="F:high molecular weight kininogen binding"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CAFA"/>
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    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044409">
        <property type="term" value="P:symbiont entry into host"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
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        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
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    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000134043" description="Enolase 1">
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            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
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            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
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        <ligand>
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        <ligand>
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            <position position="248"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="1">
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        <ligand>
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    <feature type="binding site" evidence="1">
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        <ligand>
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        <ligand>
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    <feature type="strand" evidence="5">
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    <feature type="strand" evidence="5">
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    <feature type="helix" evidence="5">
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        <location>
            <begin position="424"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="427"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="431"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1400228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7V67"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7VRD"/>
        </source>
    </evidence>
    <sequence length="440" mass="47232" checksum="6621AFD66F275C49" modified="1993-04-01" version="1">MSYATKIHARYVYDSRGNPTVEVDFTTDKGLFRSIVPSGASTGVHEALELRDGDKSKWLGKGVLKAVANVNDIIAPALIKAKIDVVDQAKIDEFLLSLDGTPNKSKLGANAILGVSLAAANAAAAAQGIPLYKHIANISNAKKGKFVLPVPFQNVLNGGSHAGGALAFQEFMIAPTGVSTFSEALRIGSEVYHNLKSLTKKKYGQSAGNVGDEGGVAPDIKTPKEALDLIMDAIDKAGYKGKVGIAMDVASSEFYKDGKYDLDFKNPESDPSKWLSGPQLADLYEQLISEYPIVSIEDPFAEDDWDAWVHFFERVGDKIQIVGDDLTVTNPTRIKTAIEKKAANALLLKVNQIGTLTESIQAANDSYAAGWGVMVSHRSGETEDTFIADLSVGLRSGQIKTGAPARSERLAKLNQILRIEEELGSEAIYAGKDFQKASQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>P46273</accession>
    <accession>A0A1D8PPF5</accession>
    <accession>Q59NN7</accession>
    <name>PGK_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoglycerate kinase</fullName>
            <ecNumber evidence="3">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGK1</name>
        <name type="ordered locus">CAALFM_C600750CA</name>
        <name type="ORF">CaO19.11135</name>
        <name type="ORF">CaO19.3651</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Microbiology" volume="143" first="321" last="330">
            <title>3-phosphoglycerate kinase: a glycolytic enzyme protein present in the cell wall of Candida albicans.</title>
            <authorList>
                <person name="Alloush H.M."/>
                <person name="Lopez-Ribot J.L."/>
                <person name="Masten B.J."/>
                <person name="Chaffin W.L."/>
            </authorList>
            <dbReference type="PubMed" id="9043109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>3153A</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2 3">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (By similarity). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (By similarity). Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text>Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="3"/>
    <dbReference type="EMBL" id="U25180">
        <property type="protein sequence ID" value="AAA66523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711323.1">
        <property type="nucleotide sequence ID" value="XM_706231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P46273"/>
    <dbReference type="SMR" id="P46273"/>
    <dbReference type="BioGRID" id="1230131">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="P46273">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P46273"/>
    <dbReference type="Allergome" id="5991">
        <property type="allergen name" value="Cand a PGK"/>
    </dbReference>
    <dbReference type="MoonProt" id="P46273"/>
    <dbReference type="EnsemblFungi" id="C6_00750C_A-T">
        <property type="protein sequence ID" value="C6_00750C_A-T-p1"/>
        <property type="gene ID" value="C6_00750C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647081"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600750CA"/>
    <dbReference type="CGD" id="CAL0000184891">
        <property type="gene designation" value="PGK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00750C_A"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_1"/>
    <dbReference type="InParanoid" id="P46273"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="BRENDA" id="2.7.2.3">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="PRO" id="PR:P46273"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="C:fungal biofilm matrix"/>
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        <property type="project" value="CGD"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:gluconeogenesis"/>
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    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
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    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGLYCERATE_KINASE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000145876" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="24"/>
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    </feature>
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        </ligand>
    </feature>
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        <location>
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        <ligand>
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    </feature>
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    </feature>
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        <ligand>
            <name>ATP</name>
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        <location>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000177918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="498" mass="56094" checksum="0E8D5F16A3A0DC30" modified="2005-04-26" version="1">MSEKLSTAVTQDESVTDTSEFDNVLYFIKENEQIIDPDSTIDGAKIVRKLDLIILPLLCCIYFLQFLDKSLLNYAAAMGIKKVLDNHGVGNNQFANLSTMFYASYIFGEPIMSYILQRYPLGKSLGVCIVLWGVVVTCHSACSSYASLMIVRTLLGIFESSSAVGLITISGMYYNKRQQVARMGIWSVMAGTATIFGGLLSFAFQHIHVQKFKSWQILFLVIGLITIAFGFFVMVYLPDNIDTVWFLNKQEKLYILNHTVRPNQTGTKSSKFKWKHIKELLILDKFTWLYFLLTICSQIVTGAIGTFSVTITLSFGFDSYQSALLQLPIGALIIIIILTATQLVSQFGHITYIIISMFIPTIVGAIVLIISPNKIGNIMALYLLYSGSSVITLIYSWTSVNTAGTSKKIFRSGMIMIAFSIACIIGPQLFQNYSAPKYHPAKIVILITQCMCIPITWLIGWMCQQENSKRDQIKDQMPENFEFFDLTDLENTQFRYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PU4</accession>
    <name>Q59PU4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">GPI8</name>
        <name evidence="9" type="ordered locus">CAALFM_C107460CA</name>
        <name evidence="8" type="ordered locus">orf19.10317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711741.1">
        <property type="nucleotide sequence ID" value="XM_706649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PU4"/>
    <dbReference type="SMR" id="Q59PU4"/>
    <dbReference type="FunCoup" id="Q59PU4">
        <property type="interactions" value="684"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PU4"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="GeneID" id="3646669"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107460CA"/>
    <dbReference type="CGD" id="CAL0000200776">
        <property type="gene designation" value="GPI8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07460C_A"/>
    <dbReference type="eggNOG" id="KOG1349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044656_2_1_1"/>
    <dbReference type="InParanoid" id="Q59PU4"/>
    <dbReference type="OMA" id="VMESQFP"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028438262" evidence="7">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000200776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="383" mass="44085" checksum="D7A79866847B7FF1" modified="2005-04-26" version="1">MNRLLSFILPIFLIFSTVLSSDSPNDSVNINNSDPSRHSNNWAVLVSTSRFWFNYRHMANTLSLYRTVKRLGIPDSQIILMLSDDIACNPRNAFPGSVFNNMDEAIDLYGESIEVDYRGYEVTVENFMRLLTDKWDSDQPRSKRLLSDENSNIFIYLTGHGGNEFLKFQDAEEISAHDLADAFSQMYDQKRYNEIFFMIDTCQANTMYEKIHSPNILAVGSSEIEESSYSHHSDMDIGVAVIDRFTYYTLDFLEKIDRDSKETMDKLFAEYTFENVHSHPGIRTDLFKRNVSEVLLTDFFGNVQNVVVDDVNMELLENEKVTESNEDNNQTKNIIKERGPTQFSFECDENSKSLIKVPQLHARIFGVVTVGVIVALWFISSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q59R99</accession>
    <name>Q59R99_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">VPH1</name>
        <name evidence="12" type="ordered locus">CAALFM_C405240CA</name>
        <name evidence="11" type="ordered locus">orf19.14153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712251.1">
        <property type="nucleotide sequence ID" value="XM_707158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59R99"/>
    <dbReference type="SMR" id="Q59R99"/>
    <dbReference type="FunCoup" id="Q59R99">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59R99"/>
    <dbReference type="GeneID" id="3646157"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405240CA"/>
    <dbReference type="CGD" id="CAL0000191982">
        <property type="gene designation" value="VPH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05240C_A"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005230_0_2_1"/>
    <dbReference type="InParanoid" id="Q59R99"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071469">
        <property type="term" value="P:cellular response to alkaline pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000191982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW29263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="821" mass="93332" checksum="0132323ABCE8991E" modified="2005-04-26" version="1">MPEKEEAVFRSADMSLVQLYVPTEVARDIIYKVGQLDIIQFRDLNSKINEFQRSFVKELRKLDNVERQFNLFKRELDVRDIPIKLFPYDLDNVPPQTEIDELIEGSDLLEERVIQLRDSVETLYEKEKYLKQFKYTIQAVNNFFAVQGETTNDNEETALLSQLESGGATSGGGGDARSGSSFISGVINRDKVGVLQQILWRVLRGNLYYHNEDLPEEIYDFKNNTYVAKSSFIIFSHGSLIRERIRKICESLDAELYNVDSTSALRREQLDDVNTKTTDLSTVLGESENALNSELIAISRDLAKWWEIIAREKAVYKAMNNCDYDNSRKTLIAEGWTPTDSITELTTAIQEYDASQSVPTIINVLDTNKTPPTYTRTNKFTYAFQAICDAYGVPKYKEINPGLPTIVTFPFMFAIMFGDLGHGFIVTLAAAALVLNEKKLNAMKKDEIFDMAYTGRYVLLLMGVFSMYTGFIYNDVFSRSMSIFKSGWEWPEKFNVGETIYAKYVGTYSIGLDPAWHGTENALLFSNSYKMKLSILMGYIHMSYSYVFSLVNYTYFNSMIDVIGNFIPGLLFMQGIFGYLSLCIVYKWSVDWFATGRQPPGLLNMLINMFLQPGDVPEPLYSGQSTIQVFLLLIALICVPWLLLVKPLYMKRQLEKEANQHHGSYSQLANDEESGVAGQEQEQENAAEDDDEDHEEHNFGDIMIHQVIHTIEFCLNCVSHTASYLRLWALSLAHAQLSTVLWSMTIGNAFGPTGLIGTFMVVFLFAMWFVLSVCILVVMEGTSAMLHSLRLHWVESMSKYFEGGGSAFEPFTFKGLLDSVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RA2</accession>
    <name>PIS_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphatidylinositol synthase</fullName>
            <shortName evidence="8">PI synthase</shortName>
            <shortName evidence="8">PtdIns synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PIS1</name>
        <name evidence="10" type="ordered locus">orf19.6860</name>
        <name evidence="11" type="ORF">CAALFM_C405210WA</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="1996" name="Yeast" volume="12" first="449" last="456">
            <title>Candida albicans phosphatidylinositol synthase has common features with both Saccharomyces cerevisiae and mammalian phosphatidylinositol synthases.</title>
            <authorList>
                <person name="Antonsson B.E."/>
                <person name="Klig L.S."/>
            </authorList>
            <dbReference type="PubMed" id="8740418"/>
            <dbReference type="DOI" id="10.1002/(sici)1097-0061(199604)12:5&lt;449::aid-yea927&gt;3.0.co;2-p"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference evidence="8" key="5">
        <citation type="journal article" date="2022" name="Fungal Genet. Biol." volume="160" first="103674" last="103674">
            <title>Function of the phosphatidylinositol synthase Pis1 in maintenance of endoplasmic reticulum function and pathogenicity in Candida albicans.</title>
            <authorList>
                <person name="Liu Y."/>
                <person name="Ma C."/>
                <person name="Mao X."/>
                <person name="Zhao Q."/>
                <person name="Yu D."/>
                <person name="Yang L."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="35227874"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2022.103674"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the synthesis of phosphatidylinositol (PtdIns) (PubMed:8740418). Required for proper membrane dynamics and cell wall integrity (PubMed:35227874).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Catalytic activity is higher with Mg(2+).</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by calcium and zinc ions (PubMed:8740418). Inhibited by nucleoside triphosphates and diphosphates (PubMed:8740418).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="5">0.55 mM for myo-inositol (at pH 9.0 and 37 degrees Celsius)</KM>
            <KM evidence="5">36 uM for CDP-diacylglycerol (at pH 9.0 and 37 degrees Celsius)</KM>
            <KM evidence="5">29 uM for 2-deoxy-CDP-diacylglycerol (at pH 9.0 and 37 degrees Celsius)</KM>
        </kinetics>
        <phDependence>
            <text evidence="5">Optimum pH is 8-9.5.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="5">Optimum temperature is 55 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Growth defect.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712248.1">
        <property type="nucleotide sequence ID" value="XM_707155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RA2"/>
    <dbReference type="SMR" id="Q59RA2"/>
    <dbReference type="FunCoup" id="Q59RA2">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59RA2"/>
    <dbReference type="EnsemblFungi" id="C4_05210W_A-T">
        <property type="protein sequence ID" value="C4_05210W_A-T-p1"/>
        <property type="gene ID" value="C4_05210W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646154"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405210WA"/>
    <dbReference type="CGD" id="CAL0000175849">
        <property type="gene designation" value="PIS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05210W_A"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_0_1"/>
    <dbReference type="InParanoid" id="Q59RA2"/>
    <dbReference type="OMA" id="VTGVFFY"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000021">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000456649" description="CDP-diacylglycerol--inositol 3-phosphatidyltransferase">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P9WPG7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="35227874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="8740418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="35227874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="8740418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="8740418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000175849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="230" mass="26212" checksum="888D45B508EAA22A" modified="2005-04-26" version="1">MPSAKSSDLSPTKTNLESTTKQKVSVQDIFLYIPNLIGYLRIITAIISFLCMANHPVATLIFYGISGFLDAFDGYAARKFNQGTRFGAVLDMVTDRCATSSLIVYLGVLYPQYTVFWQILVSLDLSSHYMHMYAMLSAGSTSHKNVDETQSKLLSLYYNNRLVLFFVCLINELFYMAVYLHYYKFFWLGTVMLVASTPIWLFKQIANIIQLKNASLILARMDAHDHSKRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S52</accession>
    <accession>A0A1D8PQR1</accession>
    <accession>Q3MPM0</accession>
    <name>MDM12_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM12</name>
        <name type="ordered locus">CAALFM_C701180WA</name>
        <name type="ORF">CaJ7.0134</name>
        <name type="ORF">CaO19.6900</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712472.1">
        <property type="nucleotide sequence ID" value="XM_707379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S52"/>
    <dbReference type="SMR" id="Q59S52"/>
    <dbReference type="FunCoup" id="Q59S52">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59S52"/>
    <dbReference type="EnsemblFungi" id="C7_01180W_A-T">
        <property type="protein sequence ID" value="C7_01180W_A-T-p1"/>
        <property type="gene ID" value="C7_01180W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645915"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701180WA"/>
    <dbReference type="CGD" id="CAL0000201825">
        <property type="gene designation" value="MDM12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01180W_A"/>
    <dbReference type="eggNOG" id="ENOG502S3PB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026794_2_0_1"/>
    <dbReference type="InParanoid" id="Q59S52"/>
    <dbReference type="OMA" id="KRAHFCF"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384277" description="Mitochondrial distribution and morphology protein 12">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="428" mass="48101" checksum="9603798B40CBFDC4" modified="2005-04-26" version="1">MSFDINWNQLTIDDTINQSIKEFLDQQFKNISLPSFISNLAVTDFNLGEIPPEVTIRHIGDPFEEFYEDENNLGVMNEANNDSKDEHLKNHGDGINKDSGYNSQNLDDEDEDDEDDDEDDEDEEEEDEDDYDDHDLGTINEGISLLNFNENSTTPSANSFAGSAAPPLPPPLNPSRDSFHSILHPYGVNSIIGATGAGSETPTNILNQNYLSSRVLPKISVKQKQPHHDDNDIQLIVEINYKGDMHINLLVNLLVNYPSPNFISLPIKLHITDIVIHSIATIAYLKKSVFLSFLCDVDDTFPDFDSNVQTPTSTTGGNFVDYYSNDATINKERIDIVKKIKIESEIGEVENNILRNVGKVEKFLVEQLRNILRDEIAWPSWICIDMNDDDDEEEEEEESEDNDGGNSDLNDNDGKHGDGRTDETEAGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S72</accession>
    <accession>A0A1D8PPV0</accession>
    <name>ALG11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.131</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alpha-1,2-mannosyltransferase ALG11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycolipid 2-alpha-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG11</name>
        <name type="ordered locus">CAALFM_C602270CA</name>
        <name type="ORF">CaO19.10972</name>
        <name type="ORF">CaO19.3468</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712508.2">
        <property type="nucleotide sequence ID" value="XM_707415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S72"/>
    <dbReference type="FunCoup" id="Q59S72">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59S72"/>
    <dbReference type="GlyCosmos" id="Q59S72">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_02270C_A-T">
        <property type="protein sequence ID" value="C6_02270C_A-T-p1"/>
        <property type="gene ID" value="C6_02270C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645871"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602270CA"/>
    <dbReference type="CGD" id="CAL0000201912">
        <property type="gene designation" value="ALG11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02270C_A"/>
    <dbReference type="eggNOG" id="KOG1387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_1_1_1"/>
    <dbReference type="InParanoid" id="Q59S72"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="PRO" id="PR:Q59S72"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000256">
        <property type="entry name" value="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000080273" description="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="217"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="477"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="609" mass="70929" checksum="D640F41FEFE276ED" modified="2017-03-15" version="2">MYLILLVVLAVYVTYKLITTVLPHHLLIPSQNWREKISYVVKYPKPIYLKVGTKRSSYRRRLILASENPAFYTNFINNKLKISPNDCENGDGFLNEMSRRDIDDPKRRIIYGFFHPYANNGGGGERVLWQAVKATLLADDKNICVIYTTNIEAQPLDILNKANKKFQIDGLDHSRVVFIYLRKFNNLIDGNYWKHFTLIGQLFGGILLSLEAMYELSPDVWIDTMGLPSSYLLVSLSLKIPILAYTHFPILQEDMFGKLKFQKLKDLWKFNIIKFNDYFALGKFIYWSILYYFYVYLGSKVNIALANGSWTFNHLSKIWVFNTALGNVLDVLYPPCGTEFLIKQANLNQPRSNKLLYLAQFRPEKRHALLLKEYSNFLSNNFPNVTQITNKFPTLVFAGSCRTADDTATLKFLQEQVAKLDLSRFVEFRIDISYDEVVELLSSCKFGLNAMWNEHFGIGVVEYMARGCTPIVHASAGPLLDMIGRNDQQENCLNNWKTDGGFFFKSYDDPDLDPNLQKNTETGYIKFELFDQFIDYPTFETLLKELYVNDPTIIEDSKLLKMRQIDQNRVAEKFSNKAFNKKWIEYINDLNTLEKQYREEKRTKVEQVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SI5</accession>
    <accession>A0A1D8PL71</accession>
    <name>MMM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MMM1</name>
        <name type="ordered locus">CAALFM_C400560CA</name>
        <name type="ORF">CaO19.11664</name>
        <name type="ORF">CaO19.4187</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MMM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712641.2">
        <property type="nucleotide sequence ID" value="XM_707548.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SI5"/>
    <dbReference type="SMR" id="Q59SI5"/>
    <dbReference type="FunCoup" id="Q59SI5">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SI5"/>
    <dbReference type="EnsemblFungi" id="C4_00560C_A-T">
        <property type="protein sequence ID" value="C4_00560C_A-T-p1"/>
        <property type="gene ID" value="C4_00560C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645744"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400560CA"/>
    <dbReference type="CGD" id="CAL0000191719">
        <property type="gene designation" value="MMM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00560C_A"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032730_2_0_1"/>
    <dbReference type="InParanoid" id="Q59SI5"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="PRO" id="PR:Q59SI5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015917">
        <property type="term" value="P:aminophospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384221" description="Maintenance of mitochondrial morphology protein 1">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="98"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="165"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="439" mass="49014" checksum="06598CBB019A1846" modified="2017-03-15" version="2">MSQDLIETTATTTKIVEARELGHQIHDSLLEQLKLQQEELLQQQRDLFFQEQQLQLQQQVTQPVSNNGNTWSFTQGLVIGQVSVIFIIIVFVKFFVFADSSSHIPTKPGLDGATGVIVKRNKNKKHSNGQFANDGENEDDTSLDSNQSKISSILEKTYYDVNNHASESLDWFNVLVAQTISQLRSEALLKDNIYHSLNNFLTNAKLPDFIDTINLTEIDIGDDFPIFSNCRIKYGEDLKRLEAKIDVDLSDTLTLGIATKLLLNQPRPLTAVLPVSLTVSIVRFSGCLTVSLINTKDIDLKNVDKTSNMNGYSKENANGDGASSSNNDEDEDDGGTALMFSFSPDYRLEFIVKSLIGSRAKLQDVPKISSLIENQLRTWFIERCVEPRFQVVRLPSLWPRTKNTREPVTKKTTTTPSTTVNGTSAATITTPGEYVNSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T38</accession>
    <name>Q59T38_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C205670CA</name>
        <name evidence="8" type="ordered locus">orf19.14168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712808.1">
        <property type="nucleotide sequence ID" value="XM_707715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59T38"/>
    <dbReference type="FunCoup" id="Q59T38">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59T38"/>
    <dbReference type="GeneID" id="3645570"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205670CA"/>
    <dbReference type="CGD" id="CAL0000194258">
        <property type="gene designation" value="orf19.14168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05670C_A"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_1_0_1"/>
    <dbReference type="InParanoid" id="Q59T38"/>
    <dbReference type="OMA" id="RTFSLEW"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000028">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="158"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000194258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="266" mass="30731" checksum="022A8F9EBA83A924" modified="2005-04-26" version="1">MNDNDDKPIATTIDNKSHNPIILPVVNPSREPEVLVFNVDDIKTLRNEYNILGVLMGTLQHYPQQNIFLSVPLKLIIWEVIWLLQYNKAILVDHLTYRDAKIKLLKGDIKNNNYQGNLITTPNSDNDYNLELAKQHQLTIYDYITNYLQDSSMSVNQFITYYKYYSYLQNKGYFINPGIKFGGDLVIYPGDPLRYHSYSIVRFEFFDVHDVVVGGRLATSVKKNLVLMGYDQEADKTHQEVNEDVISDLFDESVPLTFSIEWAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T48</accession>
    <name>Q59T48_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C205570CA</name>
        <name evidence="5" type="ordered locus">orf19.14158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712800.1">
        <property type="nucleotide sequence ID" value="XM_707707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59T48"/>
    <dbReference type="SMR" id="Q59T48"/>
    <dbReference type="FunCoup" id="Q59T48">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="GeneID" id="3645562"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205570CA"/>
    <dbReference type="CGD" id="CAL0000175407">
        <property type="gene designation" value="orf19.14158"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05570C_A"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="InParanoid" id="Q59T48"/>
    <dbReference type="OMA" id="RHVKFIP"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08247">
        <property type="entry name" value="AST1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000175407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="349" mass="39091" checksum="886E12EE35B934CC" modified="2005-04-26" version="1">MTKLTYKRYGFKNGGSPLEIITDSFDFPTDAQGNFIIPKNKILIKIYYASLNPVDYKLKKITYFPPFSLHGIGKDYSGEIVGLGSNVKNFKVGEFVQGFHPGVITDDGTFSQYLLIDTKGLFKTEIATVPQNISLEQAAAWPLVLGTAIKVISDLPIKGKKILVFGGATSVGRYLVQLLQAEKAGEIVVSCSPRSQELVTELGATKIINYRENVLNQVLENVKDKPFDYIFDTWGGNELFPHLKQILVKNGTYHTIVGDDPHSFFTGTSKSFFRTFLSWLHLLDYSYQYVLLGAGGTGWINKAREYVANDDVQIFIDKIYKFEDLNDAIEYNKTGTAQGKLIINVKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TV1</accession>
    <name>Q59TV1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C111740WA</name>
        <name evidence="2" type="ordered locus">orf19.8736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713012.1">
        <property type="nucleotide sequence ID" value="XM_707919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TV1"/>
    <dbReference type="SMR" id="Q59TV1"/>
    <dbReference type="STRING" id="237561.Q59TV1"/>
    <dbReference type="GeneID" id="3645317"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111740WA"/>
    <dbReference type="CGD" id="CAL0000189999">
        <property type="gene designation" value="orf19.8736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11740W_A"/>
    <dbReference type="eggNOG" id="ENOG502S4MM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026920_0_0_1"/>
    <dbReference type="InParanoid" id="Q59TV1"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000189999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="394" mass="46671" checksum="AD2CE46B8C9E0DB4" modified="2005-04-26" version="1">MVSRSHSSTPVPIDADHPIHFLNIGNQDQIASLSKQTPIILLNQQEENGFQTPELVALRNSNKYVFVINWLYNYRGYLKLQSELFDIDLFELELLGFFNAFDLSSLFINKLKLALITSVQNSKLVELEDFEFVFRAHFGDDSPLGIQTDNEQDSVKFDLLNITEKFDILYILINYISKYSKFRDWTEKQGLTTRIDPIFKSSSAEYFSLFDDNRLYKRTITYYPLTIPKKRKLSPESPQDYFDSKVFDVKDVKFELVYKNIYEFNEYLSKIKKSSAHKLLYTKLAGKSSTIIDTIFDNEVKKRRYLINKRKEIQMVNLLAVRKRSSRLEAKERQRQEELERQREEESKQAAERRFERRMKLKNTENMDTGKLSRDQRMQLRQLNYEPTPEPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q59U53</accession>
    <name>Q59U53_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C207360WA</name>
        <name evidence="9" type="ordered locus">orf19.9456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713157.1">
        <property type="nucleotide sequence ID" value="XM_708064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59U53"/>
    <dbReference type="SMR" id="Q59U53"/>
    <dbReference type="FunCoup" id="Q59U53">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59U53"/>
    <dbReference type="GeneID" id="3645236"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207360WA"/>
    <dbReference type="CGD" id="CAL0000179420">
        <property type="gene designation" value="orf19.9456"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07360W_A"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567394_0_0_1"/>
    <dbReference type="InParanoid" id="Q59U53"/>
    <dbReference type="OMA" id="INPINLY"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000179420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="483" mass="55276" checksum="596BD2511F2599C5" modified="2005-04-26" version="1">MYDANNEHSADDKLTARELSPQSVPINLEANKITKKRKKKKKSRKKKTKNQNIGDSELDRIEQDTQITPQVERDDFPAPLPYDYDPLSYNQFVSPSDTSHENPKRYRGELLTHTIDTLPAPVKKFWKRRYALFEKFDEGIYLSSELWYSVTAESIAKYTANLFRDLLPNATSGLDLCCGGGGNTIQFAKIFDNIGALDINPINLYCTKNNCKVYGVQDNVWTIEADWNEVSELKDGNVNTEWIPEGIRRSENEETLQFDFVFSSPPWGGTSYNRKVFDLNSMEPFPITRMLQQIKRYTNNVGLYLPRSSNLEQLQEAALKTFGEEGRCRVVHIRSDGRIVAIIALIGKELIENFDNIYNDKEEDEEETSDENCSNEAQTSENEEIDRTSNAAYNEDSNEDENMTEYSHDTEHELNEEGNSGNDKDSSGDDINNNPESETEGKDSTKKVSAEELQKIIQEYENSSSAFQYDEVLEDYENDIDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UY8</accession>
    <name>Q59UY8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">RAD51</name>
        <name evidence="12" type="ordered locus">CAALFM_CR02200CA</name>
        <name evidence="11" type="ordered locus">orf19.11236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713440.1">
        <property type="nucleotide sequence ID" value="XM_708347.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UY8"/>
    <dbReference type="SMR" id="Q59UY8"/>
    <dbReference type="FunCoup" id="Q59UY8">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59UY8"/>
    <dbReference type="GeneID" id="3644944"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02200CA"/>
    <dbReference type="CGD" id="CAL0000180182">
        <property type="gene designation" value="RAD51"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02200C_A"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="InParanoid" id="Q59UY8"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905334">
        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007533">
        <property type="term" value="P:mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000708">
        <property type="term" value="P:meiotic strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036298">
        <property type="term" value="P:recombinational interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097752">
        <property type="term" value="P:regulation of DNA stability"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010570">
        <property type="term" value="P:regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="115"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="294"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000180182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="361" mass="39549" checksum="D68503CDF590D36F" modified="2005-04-26" version="1">MTQTEIEQVDLHEEGSHPQNINADAEVEAEEDEDVLNGPLLIEQLEGNGINASDIKKLKAEGFHTIESIAYTPKRHLMTVKGISENKAEKISAEAAKLVPLGFTTASEFHSRRSELICLTTGSKQLDTLLGGGVETGSITEVFGEFRTGKSQLCHTLAVTCQLPIDMGGGEGKCLYIDTEGTFRPNRLVSIAQRYGLNPNDCLDNVAYARAYNAEHQLNLLNIAAEMMAESRFSLLIVDSIMSLYRTDYAGRGELSARQTHVAKFMRTLQRLADEFGIAVVITNQVVAQVDGMSGMFNPDPKKPIGGNIIAHSSTTRLSFKKGRGETRICKIYDSPCLPESECIFAIYEDGIGDPKVEDNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VP1</accession>
    <accession>A0A1D8PD85</accession>
    <name>H2B2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2B.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HTB2</name>
        <name type="ordered locus">CAALFM_C104180WA</name>
        <name type="ORF">CaO19.1052</name>
        <name type="ORF">CaO19.8654</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BK7ac = acetylated Lys-8; H2BK7su = sumoylated Lys-8; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK16ac = acetylated Lys-17; H2BK16su = sumoylated Lys-17; H2BK17su = sumoylated Lys-18; H2BK123ub1 = monoubiquitinated Lys-124.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713656.1">
        <property type="nucleotide sequence ID" value="XM_708563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VP1"/>
    <dbReference type="SMR" id="Q59VP1"/>
    <dbReference type="BioGRID" id="1227729">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59VP1">
        <property type="interactions" value="1176"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VP1"/>
    <dbReference type="EnsemblFungi" id="C1_04180W_A-T">
        <property type="protein sequence ID" value="C1_04180W_A-T-p1"/>
        <property type="gene ID" value="C1_04180W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644716"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104180WA"/>
    <dbReference type="CGD" id="CAL0000199081">
        <property type="gene designation" value="orf19.8654"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04180W_A"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="InParanoid" id="Q59VP1"/>
    <dbReference type="OMA" id="SEVEYMG"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="PRO" id="PR:Q59VP1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000245456" description="Histone H2B.2">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="130" mass="14103" checksum="FF1E08AA9ADEF7CB" modified="2007-01-23" version="3">MAPKAEKKPASKAPAEKKPAAKKTASTDGAKKRTKARKETYSSYIYKVLKQTHPDTGISQKAMSIMNSFVNDIFERIASEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WK1</accession>
    <name>Q59WK1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C111150WA</name>
        <name evidence="4" type="ordered locus">orf19.9837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710041.1">
        <property type="nucleotide sequence ID" value="XM_704949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WK1"/>
    <dbReference type="SMR" id="Q59WK1"/>
    <dbReference type="FunCoup" id="Q59WK1">
        <property type="interactions" value="1121"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WK1"/>
    <dbReference type="GeneID" id="3648356"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111150WA"/>
    <dbReference type="CGD" id="CAL0000199691">
        <property type="gene designation" value="orf19.9837"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11150W_A"/>
    <dbReference type="eggNOG" id="KOG3129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073146_0_0_1"/>
    <dbReference type="InParanoid" id="Q59WK1"/>
    <dbReference type="OMA" id="DWGGRGM"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000378">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="3">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
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            <end position="212"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26373" checksum="11CFABA6BED45AA9" modified="2005-04-26" version="1">MTVDESDVSGSFQGLMRSLNLDSEQFKEYDDIDFESLNFIQLSHVKDEIENQLNILFDLLRHKYNADMDTPLVTPDGFPRSDLDVVTIRLLRIRIIRLRNDDRKVIHLLDDRMAQEFATRRESNIEAGEEESTTSSTSRYHIPFAQVREVVSGGPAFNSGLKEGDQIIVFDDDIHAANNNKLGSLVSRVRSKQNEEIKVDLKRGEERITLKLIPSDNWDGQGLLGCRLIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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    <reference evidence="8 9" key="1">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
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        <subcellularLocation>
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            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
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    </evidence>
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        <source>
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    <sequence length="182" mass="21175" checksum="4E223B83DBB9A87C" modified="2005-04-26" version="1">MPAYHSTFLAEEQNQSINSGIRTIGNLSLLPFHTNFRGPIYSENNSDYDIIEEVLDLFRANSFFKNFEIKGNSDRLLIYGILFINQCLTKLTKFTNSKEATKILINLSVDNFHLPGDIGFPLNSLYVSPANKSEYELLKNYLTQFRQELSDRLIKRIYHDDPNIPSKHWLAFTKRKFMNKSL</sequence>
</entry>
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    <accession>Q59X30</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="102" mass="11969" checksum="D39D1833A7B3C814" modified="2005-04-26" version="1">MNYTKKQKEAILNHLRLERAKVAKRNEISKKKLADQTSQKVLRRLNGVSVTLWDIKLKDIFQVERSKKLVAKNLVRDVQDMRRKLLLEQKKSPSKTTHTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XV1</accession>
    <name>Q59XV1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
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    </protein>
    <gene>
        <name evidence="16 17" type="primary">CMK2</name>
        <name evidence="17" type="ordered locus">CAALFM_C210260CA</name>
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    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714400.1">
        <property type="nucleotide sequence ID" value="XM_709307.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="3643961"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210260CA"/>
    <dbReference type="CGD" id="CAL0000178532">
        <property type="gene designation" value="CMK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10260C_A"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
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    <dbReference type="OMA" id="HDWFESR"/>
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        <property type="organism ID" value="1096"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000178532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW28003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="477" mass="53775" checksum="33374EA7991C16BB" modified="2005-04-26" version="1">MSTDHHSHPVEGHQFKKIFNRLSGQPESYSRKQNYTFGKTLGAGSFGIVRYARDNSTDEEVAVKIILKKALKGNESMIIDEMQLLEQLNNPHIVGFRDWFESKDKFYLVTQLATGGELFDRIVQKGRFTEHDASLVVLQMLEALEYLHNKDIVHRDIKPENILYLTSKDDSPIVLADFGIAKRLQNPNEKLTSSAGSFGYAAPEVILGTGHGKPCDIWSLGVVTYTLLCGYSPFRSENVQDFINEVKHNNAVIFHADYWKDVSKDARRFIIKALQFNPDNRPTATELLNDPWLVSIAKEYKETDLLPNFKQGFDAKKKFRQAIELVKLNNRIKKLKEWQTDEDDDPTEINLFNEHGSVEQRANPSTNDGLTIPGTTSPRRGESPLNTWKKFNDVINSLDTNRSKASLSSFKSPYDLAHSNRGTDVSNSGATNVGKSDTASSAFVQLVHAATANKEKVANYTEDEEGKEKKQKDGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A214</accession>
    <name>Q5A214_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Processing of GAS1 and ALP protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_CR02700WA</name>
        <name evidence="3" type="ordered locus">orf19.10347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715760.1">
        <property type="nucleotide sequence ID" value="XM_710667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A214"/>
    <dbReference type="FunCoup" id="Q5A214">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A214"/>
    <dbReference type="GeneID" id="3642575"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02700WA"/>
    <dbReference type="CGD" id="CAL0000198238">
        <property type="gene designation" value="orf19.10347"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02700W_A"/>
    <dbReference type="eggNOG" id="ENOG502S88B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150165_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A214"/>
    <dbReference type="OMA" id="FGWGNKT"/>
    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022909">
        <property type="entry name" value="UCP022909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000198238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW31013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="15186" checksum="26AF8F3EA7DDC0EA" modified="2005-04-26" version="1">MAAFDEIFDYVDRDTFFQYFRLTLVVCTYLIFRKYYSSWAIKKQTATQLEQDKREQSEKSEREAKESKEKFDTISNEAKEFGWGKKTRNNVKLTEAVLAEYSEQQRQRNQTSYDAQEDADIDDLLED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-01" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A310</accession>
    <accession>A0A1D8PKM1</accession>
    <name>ISW2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ISWI chromatin-remodeling complex ATPase ISW2</fullName>
            <ecNumber>3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ISW2</name>
        <name type="ordered locus">CAALFM_C306310CA</name>
        <name type="ORF">CaO19.7401</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Microbiology" volume="149" first="3629" last="3637">
            <title>Genetic control of chlamydospore formation in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Bruno V.M."/>
                <person name="Richard M.L."/>
                <person name="Davis D.A."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="14663094"/>
            <dbReference type="DOI" id="10.1099/mic.0.26640-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="1018" last="1032">
            <title>Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Enjalbert B."/>
                <person name="Smith D.A."/>
                <person name="Cornell M.J."/>
                <person name="Alam I."/>
                <person name="Nicholls S."/>
                <person name="Brown A.J.P."/>
                <person name="Quinn J."/>
            </authorList>
            <dbReference type="PubMed" id="16339080"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-06-0501"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ISW2 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="7 8">Expression is induced by the HAP43 transcription factor and repressed in response to high doses of peroxide stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-"/>
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        <property type="protein sequence ID" value="AOW28638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716066.1">
        <property type="nucleotide sequence ID" value="XM_710973.1"/>
    </dbReference>
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        <property type="interactions" value="1227"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A310"/>
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        <property type="protein sequence ID" value="C3_06310C_A-T-p1"/>
        <property type="gene ID" value="C3_06310C_A"/>
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    <dbReference type="GeneID" id="3642235"/>
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        <property type="gene designation" value="ISW2"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000781">
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        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0019237">
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    <dbReference type="GO" id="GO:0004386">
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    <dbReference type="CDD" id="cd17997">
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    <dbReference type="FunFam" id="1.10.10.60:FF:000447">
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    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000422104" description="ISWI chromatin-remodeling complex ATPase ISW2">
        <location>
            <begin position="1"/>
            <end position="1056"/>
        </location>
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        <location>
            <begin position="151"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="457"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="4">
        <location>
            <begin position="833"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="14663094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="16339080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="1056" mass="123094" checksum="CCC6AC16C1F2A9E0" modified="2005-04-26" version="1">MTTTSTTTTNTTNGQFCSDESLEERRKRFLLEVDAKHERAHDKDDATKRFQYLLGLSALFRKFINLNASKDPAFKKRIREIDSKTSFKESSKKAKNSRRRKTEKEEDAELLQDEEHQDDEDHQHTVMTESPSYIKEGKLREYQIQGLNWLISLYENRLSGILADEMGLGKTLQTISFLGYLRYIKHIDGPFIVIVPKSTLDNWRREFAKWTPDVNVVVLQGDKEQRASIIKDQLYTAKFDVLITSFEMILREKSALQKFRWEYIVVDEAHRIKNEDSSLSKIIRLFYSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDSDQFDEAFDNQNSEELDEEEKQRRQDKAVSELHQLLSPFLLRRVKADVEKSLLPKIETNVYIGMTDMQVEWYKRLLEKDIDAVNGVVGKREGKTRLLNIVMQLRKCCNHPYLFDGAEPGPPYTTDEHLVYNSGKMIILDKMLKKFKAEGSRVLIFSQMSRVLDILEDYCYFRDYEYCRIDGSTSHEDRIEAIDEYNAPDSEKFIFLLTTRAGGLGINLTSADIVILYDSDWNPQADLQAMDRAHRIGQKKQVKVFRFVTEKAIEEKVLERAAQKLRLDQLVIQQGRQMNSNNNVGNSKDDLIGMIQHGAKEVFENSKGTMLDDDVEEILKRGAEKTAELNNKFNKLGLDDIQNFTSDASAYEWNGQDFTKKGNNASLGLNWINPSKRVRKELTYSVDNYYKDVLKQPAVVKEKVVKQPVVKPKAPKSYNVQDHQFFADELVTLLEREQLAFKKEISYQYSVDDFGDSDEEFLEQDDEDDMTRDEKRKIAQEKINNAVALTEEEIATRDRLLEESFHNWSRRDFTNFIHATAKYGRNEYKKIAKALGNKKRSEIERYSKMFWQNYQKIEGYEKYLSQIEAVEKKREKLINQQKLLAKKIESLQDPLEDLKIQYPPNNSKRVYSKTEDKFLLYCVHKYGLSTENLYDKIKDEILTSDIFKFDWYIRSRTPQEIGRRISTLLLAITREMEGPLHGKKRKAMGESNNSSRFGSVEPSSINGEKHSPEVIDNEQTVKKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3K3</accession>
    <name>Q5A3K3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CWP419</name>
        <name evidence="4" type="ordered locus">CAALFM_C111990WA</name>
        <name evidence="3" type="ordered locus">orf19.12732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716336.1">
        <property type="nucleotide sequence ID" value="XM_711243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3K3"/>
    <dbReference type="STRING" id="237561.Q5A3K3"/>
    <dbReference type="GeneID" id="3642042"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111990WA"/>
    <dbReference type="CGD" id="CAL0000196406">
        <property type="gene designation" value="CWP419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11990W_A"/>
    <dbReference type="eggNOG" id="ENOG502RMMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113788_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A3K3"/>
    <dbReference type="OMA" id="IYATEYI"/>
    <dbReference type="OrthoDB" id="4022855at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971211" evidence="2">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000196406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="161" mass="17037" checksum="614092B059DD9DEC" modified="2005-04-26" version="1">MLSSKIYSLVLLSLFGLARSADDVTTTITTTPYVTATTTVGLQEDIYATEYIYTDDNGKLTTTTVLASTVTNPAVLQGTTPTTKPSADPSSSDDNSNKPSSSTTATSDNSESSPTGFFTEIKVEVPEGVYSTSTKYTHTVLDDGQTAALELVVLYTAFCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4N6</accession>
    <name>Q5A4N6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Formate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C601780CA</name>
        <name evidence="9" type="ordered locus">orf19.10909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716716.1">
        <property type="nucleotide sequence ID" value="XM_711623.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4N6"/>
    <dbReference type="SMR" id="Q5A4N6"/>
    <dbReference type="FunCoup" id="Q5A4N6">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4N6"/>
    <dbReference type="GeneID" id="3641636"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601780CA"/>
    <dbReference type="CGD" id="CAL0000182549">
        <property type="gene designation" value="orf19.10909"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01780C_A"/>
    <dbReference type="HOGENOM" id="CLU_020549_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A4N6"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140299">
        <property type="term" value="F:molecular sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001225">
        <property type="term" value="P:regulation of chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000182549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52216" checksum="09AC01B2D7CF70C3" modified="2005-04-26" version="1">MDDNLYLTTYEAALAVVATAMKKARLRIDVLVINSFMGGMLFTTGGMLYDLIRAGFSGINETNPGVISLLQGICYPIGLFYVVILGVDLFNSNILFFSTALCRGAVSFLDLFISWFVSWWFNLVGNIFVCYIFCYYSDVVRTQLMVVGSVEVAVQKAESTFVETLLKATAGNFYVCLAIFLQLMAKPLHVKFLMMLLPVFTFVAMGFTHSVADMFLVTMGLINGAPISVGKAAWKVFLPGAIGNIIGGSFFGVVITWYLHIYVVERDRAALNLPQYELRDEQPELNQDSRVVRKKSPRMEDEVVHTNKFDDSEESEEIQAPEDFYPTPVYDETSIQSYRLTHRKTRDSISSLRSTRRSPKNVFPVYGMGAPLKRERTIAGEVSTPAEPMDEKLEEEAEYIGTRLRKAISNRSKVSDLEANKSPSNHGSRQPTPRSSFSRRSSNVGIIKSSEGPDPTDSNIDLADIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4Z9</accession>
    <name>Q5A4Z9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">MRP17</name>
        <name evidence="9" type="ordered locus">CAALFM_C500420CA</name>
        <name evidence="8" type="ordered locus">orf19.8562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716786.1">
        <property type="nucleotide sequence ID" value="XM_711693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4Z9"/>
    <dbReference type="SMR" id="Q5A4Z9"/>
    <dbReference type="FunCoup" id="Q5A4Z9">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4Z9"/>
    <dbReference type="GeneID" id="3641548"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500420CA"/>
    <dbReference type="CGD" id="CAL0000191831">
        <property type="gene designation" value="MRP17"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00420C_A"/>
    <dbReference type="eggNOG" id="KOG4708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126331_3_0_1"/>
    <dbReference type="InParanoid" id="Q5A4Z9"/>
    <dbReference type="OMA" id="HQIGDYW"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000191831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="119" mass="13510" checksum="191CC90F3F7A773B" modified="2005-04-26" version="1">MYYELFAIARITDPLNTAKEATKIASTVGKLILNNRGIIRDITSLGAKPLPQIISKEQERHFQGYHFIIGFDSSPNVQTQLLRTLRRDPRILRSSIMKHDLTHNLNPGTTIEQALRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5B4</accession>
    <accession>Q3MP60</accession>
    <name>Q5A5B4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein serine/threonine kinase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">DBF4</name>
        <name evidence="8" type="ordered locus">CAALFM_C702950CA</name>
        <name evidence="7" type="ordered locus">orf19.12633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716988.1">
        <property type="nucleotide sequence ID" value="XM_711895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5B4"/>
    <dbReference type="SMR" id="Q5A5B4"/>
    <dbReference type="FunCoup" id="Q5A5B4">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A5B4"/>
    <dbReference type="GeneID" id="3641388"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702950CA"/>
    <dbReference type="CGD" id="CAL0000174858">
        <property type="gene designation" value="DBF4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02950C_A"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023948_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A5B4"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="444"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000174858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="506" mass="58030" checksum="22897EDFBC7B278D" modified="2005-04-26" version="1">MSKVEEHESVNNLKRKFPSLAKPRQPLKETNSNIPSPHKRAKIESPSKQQSTQQPQQQPQPQPQPQPQQEKATHKPKKSSHQSKNNDKLAGDEMHEWQQSWRRIMKSSIVYFEGDQQSLEYRKAHKLLRLVGCKVTPFYDNNVTIIISKRPYDSKTEYSPHDIFSNVSKASIKVWNYDKVFRFLKHLGINIQTGVDELAVNTHTILPPSLTNNNEKPDLYNLLKEEKIYGSTDRDPNAKRDDLHYLGKNYLYVYDLTQTVRPIAIREWSDHYPVMQLSLDGKCPFIEDPTDQNSERKRLKRLRKFEANQAHREALRLATYKMINGISMSVHGFTATSTSTDKVDEEEDSTVKEPSEDPRFRQPLNRNSSCMQSKAFEAMASGYNGASNAVQPSMDSNLNSAAAMAGGNGLGPALSQVPSKQLNNLKRRILMKKKTTNTTEKKDKEHASGYCENCRVKYTNFDEHIMTNRHRNFACDDRNFQDIDELIASLRERKSLGNVISNGDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A678</accession>
    <name>Q5A678_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ssz1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">SSZ1</name>
        <name evidence="6" type="ordered locus">CAALFM_C404700WA</name>
        <name evidence="5" type="ordered locus">orf19.11293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717217.1">
        <property type="nucleotide sequence ID" value="XM_712124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A678"/>
    <dbReference type="SMR" id="Q5A678"/>
    <dbReference type="FunCoup" id="Q5A678">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A678"/>
    <dbReference type="GeneID" id="3641139"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404700WA"/>
    <dbReference type="CGD" id="CAL0000182719">
        <property type="gene designation" value="SSZ1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04700W_A"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="InParanoid" id="Q5A678"/>
    <dbReference type="OMA" id="DQVLMDH"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000182719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="540" mass="58530" checksum="7FFBC33C39243A8C" modified="2005-04-26" version="1">MSVIGITFGNTSSSIAVASADGKVDVIANPDGDRSIPSALSYIGADEYHGSQAEARLIRNPENTIVNFRDYIGKKFSEINPNTTTGAKPKEINGEISYEITNDGKTEILTVHEVAKRHFKQLKLAAEDFIGKNIEGVVLTVPTDFTEVQRQEIARIAEDAGLKVLQLINEPSAALLAHLSNDEDRLSQDKIYVVADFGGIRTDGAVIAVRGGVLTILATAHEYGLGGDNLDAALSEYFAKEFEKKYKANPRNNARSLAKLKAESIVVKKTLSNVQTSTCSIESLADGFDFHTSINRLRYELTARDPLSKMTAFVEKVIAKADLDPLDIDEVLLVGGAAHTPKLASNISFLFPETTNIIAPSLDSKALNPSELVALGAALQASLVESFDESEIKESLQPIVVNTQHLSKPIGIKDADGNFQPILVAETAYPIKKSIEVTNGDSTSVIVELYEGKRTVKETVIEAEPVEDSEDEDSEEEEPEIKREVVYECGDKLAELSLKDLKPNANLEVIVNITQNGVLHLSGRELKQGSIAVKGEITSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6B6</accession>
    <accession>A0A1D8PM78</accession>
    <accession>Q5A6J5</accession>
    <name>PPG1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase PP2A-like PPG1</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PPG1</name>
        <name type="ordered locus">CAALFM_C405050CA</name>
        <name type="ORF">CaO19.11256</name>
        <name type="ORF">CaO19.3774</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Nat. Genet." volume="42" first="590" last="598">
            <title>Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.</title>
            <authorList>
                <person name="Noble S.M."/>
                <person name="French S."/>
                <person name="Kohn L.A."/>
                <person name="Chen V."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="20543849"/>
            <dbReference type="DOI" id="10.1038/ng.605"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Eukaryot. Cell" volume="7" first="1640" last="1648">
            <title>Identification of the putative protein phosphatase gene PTC1 as a virulence-related gene using a silkworm model of Candida albicans infection.</title>
            <authorList>
                <person name="Hanaoka N."/>
                <person name="Takano Y."/>
                <person name="Shibuya K."/>
                <person name="Fugo H."/>
                <person name="Uehara Y."/>
                <person name="Niimi M."/>
            </authorList>
            <dbReference type="PubMed" id="18708562"/>
            <dbReference type="DOI" id="10.1128/EC.00129-08"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="Eukaryot. Cell" volume="13" first="1538" last="1547">
            <title>Ppg1, a PP2A-type protein phosphatase, controls filament extension and virulence in Candida albicans.</title>
            <authorList>
                <person name="Albataineh M.T."/>
                <person name="Lazzell A."/>
                <person name="Lopez-Ribot J.L."/>
                <person name="Kadosh D."/>
            </authorList>
            <dbReference type="PubMed" id="25326520"/>
            <dbReference type="DOI" id="10.1128/EC.00199-14"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MUTAGENESIS OF ASP-90; HIS-173 AND HIS-248</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Serine/threonine-protein phosphatase that plays an important role in controlling colony morphology, filament extension and agar invasion. Down-regulates expression of NRG1 and affects the expression of multiple filament-specific transcripts in response to serum and 37 degrees Celsius. Plays a crucial role in virulence in a mouse model of systemic candidiasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by okadaic acid, a specific inhibitor of serine/threonine phosphatases of types 1, 2A and 2B.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to defect in morphogenesis and reduced virulence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family. PP-2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717179.1">
        <property type="nucleotide sequence ID" value="XM_712086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6B6"/>
    <dbReference type="SMR" id="Q5A6B6"/>
    <dbReference type="FunCoup" id="Q5A6B6">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6B6"/>
    <dbReference type="EnsemblFungi" id="C4_05050C_A-T">
        <property type="protein sequence ID" value="C4_05050C_A-T-p1"/>
        <property type="gene ID" value="C4_05050C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641143"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405050CA"/>
    <dbReference type="CGD" id="CAL0000190355">
        <property type="gene designation" value="PPG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05050C_A"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_2_1"/>
    <dbReference type="InParanoid" id="Q5A6B6"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PHI-base" id="PHI:4878"/>
    <dbReference type="PRO" id="PR:Q5A6B6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000168">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000431445" description="Serine/threonine-protein phosphatase PP2A-like PPG1">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="sequence variant" description="In allele: CaO19.11256.">
        <original>S</original>
        <variation>STKHGKVDDSS</variation>
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity; when associated with A-173 and A-248." evidence="5">
        <original>D</original>
        <variation>L</variation>
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity; when associated with L-90 and A-248." evidence="5">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity; when associated with L-90 and A-173." evidence="5">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P67775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20543849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="25326520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="25326520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="416" mass="47040" checksum="1E48676379B30EEC" modified="2005-04-26" version="1">MTVPFKIPISDLDYCLEQLLDHKPPKILPPETIQQLCHTLKTELLQTPNIISLQSPISVVGDIHGQYHDLLEIFQIGGSPPQTNYLFLGDYVDRGYYSVETISLLLVLKLRYPERVFLIRGNHESRTITTNYGFYTEVLNKYQGSADVWTFITDLFDYLPLGATIDGKIFACHGGLSPSCQQLDQIRAVDRFREIPHDGIMADLVWSDPDVAISDFKLSPRGAGYLFGNDVIDKFCQDNNLVQMIRAHQLCNEGYTSYWKGKCLTVWSAPNYCYRCGNKASVLEILHSNYDSKDPTNGSDGEISSINGEFIGVNTSFESFGDDDDDYNDYRNRFNNSSRLHKQQGVLPGQFFNVFEASKENDEDTLQGKSVNGINFDDELSTSDDTSGSGGNNNKGDFFAAFFQERPKRQQVEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AA00</accession>
    <name>Q5AA00_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C105670WA</name>
        <name evidence="11" type="ordered locus">orf19.10020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718505.1">
        <property type="nucleotide sequence ID" value="XM_713412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AA00"/>
    <dbReference type="SMR" id="Q5AA00"/>
    <dbReference type="FunCoup" id="Q5AA00">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AA00"/>
    <dbReference type="MEROPS" id="M28.006"/>
    <dbReference type="GeneID" id="3639899"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105670WA"/>
    <dbReference type="CGD" id="CAL0000183285">
        <property type="gene designation" value="orf19.10020"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05670W_A"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AA00"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009024779" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="198"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000183285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="417" mass="47466" checksum="618A36972F585965" modified="2005-04-26" version="1">MRITVILGFTVCLTNAFPLDFPEWTTNAVSFFTNDGYRNSDRLIKLGPENYRIVSENEKLKLKRNKINFIDVTNQIPIESAIEQGLTLKPAPPSLWRKFQLMGSKQITTLKKKIPVYNYPKHPQYEKKVLSIFQSINVEFMQEKLSKFTSFYTRYYKSDYGAESAEWLYQQISDIIAPVKDTVTISKVEHKGWKQFSIIVSIPGKVTDKVVVGAHQDSANLILPNLMKAPGADDDGSGTVTILESLRLLIASYKDGTFKPYNTLEFHWYSAEEGGLLGSIDVFTRYSESNQVVVGMLQQDMTGYTQGSIDQGIEPHFGLIADYTSVELNNFLKQIITNYNSIPYHESECGYACSDHASALENGYPSSFLIESEMKYSNKYIHSTMDTIDRLDWAHIKEHVKLTVAYAYELSLARNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB70</accession>
    <name>Q5AB70_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C100090WA</name>
        <name evidence="2" type="ordered locus">orf19.13522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719062.1">
        <property type="nucleotide sequence ID" value="XM_713969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AB70"/>
    <dbReference type="FunCoup" id="Q5AB70">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AB70"/>
    <dbReference type="GeneID" id="3639304"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100090WA"/>
    <dbReference type="CGD" id="CAL0000185968">
        <property type="gene designation" value="orf19.13522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00090W_A"/>
    <dbReference type="eggNOG" id="ENOG502S5GM">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120591_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AB70"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="173" mass="20589" checksum="8C02F6E23BAC1D3B" modified="2005-04-26" version="1">MAGKESCETERKKKIPSIFLRCKKSGVVMSSTEDELVRQLAQHTDLSSLASFNSSIHPYQFDFIIEHERGIKLFGIPLFSHKSLWPIIDPSHYQSINGKKLSIPISLENYPLPDFDWQWQWDRWYVFMFNDVDPHGWMYSNVFFQCAKWKGKYYFGNTVRKRVWIRLRKKCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ACV3</accession>
    <name>Q5ACV3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C200180CA</name>
        <name evidence="11" type="ordered locus">orf19.9662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719560.1">
        <property type="nucleotide sequence ID" value="XM_714467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ACV3"/>
    <dbReference type="SMR" id="Q5ACV3"/>
    <dbReference type="STRING" id="237561.Q5ACV3"/>
    <dbReference type="GeneID" id="3638905"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200180CA"/>
    <dbReference type="CGD" id="CAL0000195364">
        <property type="gene designation" value="orf19.9662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00180C_A"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ACV3"/>
    <dbReference type="OMA" id="ATMYKMS"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000195364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW27072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="303" mass="34391" checksum="B1827C3CBF03E38B" modified="2005-04-26" version="1">MQSELYSSTYGKGNVKFLKVKKDPSNPTVQDVLEANVQVLLRGKFDESYTKADNSSIVPTDTVKNTILVEAKTTDVWPIERFAAHLAKHFTTKYGHVDGIEVTIIQAKWSKIKLEGKEHAHSFKHEGPETRRTYLNYDKHTKKLQLSSSIKDLTVLKSTGSMFYGYNVCDYTTLQPTKDRILSTDVDASWTFDPTQIATLDDILSQPKLFDTTYNTARDVTLELFCKENSPSVQSTMYNMSHKILETVKQVGTVSYVLPNKHYILFNLEWKGIKDNKDLFYPAPDPNGLIKSTVGRKGDKAKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ACW2</accession>
    <accession>A0A1D8PG25</accession>
    <name>CWC24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CWC24</name>
        <name type="ordered locus">CAALFM_C200280CA</name>
        <name type="ORF">CaO19.2105</name>
        <name type="ORF">CaO19.9653</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719551.2">
        <property type="nucleotide sequence ID" value="XM_714458.2"/>
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        <property type="interactions" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5ACW2"/>
    <dbReference type="EnsemblFungi" id="C2_00280C_A-T">
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        <property type="gene ID" value="C2_00280C_A"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C200280CA"/>
    <dbReference type="CGD" id="CAL0000187163">
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    <dbReference type="OrthoDB" id="25761at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000055885" description="Pre-mRNA-splicing factor CWC24">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="2">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="216" mass="24232" checksum="CC2A2DEFDE9D1EC8" modified="2017-04-12" version="2">MFKKRVIKDSRVSKRKIGDINEASEDAPDTQVTKKSTLITKKSDIQKKSVVMPRSSPQTPLSKSSSDDAAAVEVVSQKSKKGELKPLAANIKTTIITDFQPDVCKDFQQTGYCGYGDTCKFLHVRDESRQKIPIKKDWEIGGQKEVKEKEDIPFKCVLCKSDYKSPIKTECGHIFCKACFLDRYKAKKKGTCFICHKETNGTMVPVNIDKLSATQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADX8</accession>
    <name>Q5ADX8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wor4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">WOR4</name>
        <name evidence="5" type="ordered locus">CAALFM_C307730WA</name>
        <name evidence="4" type="ordered locus">orf19.14005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719813.1">
        <property type="nucleotide sequence ID" value="XM_714720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADX8"/>
    <dbReference type="SMR" id="Q5ADX8"/>
    <dbReference type="STRING" id="237561.Q5ADX8"/>
    <dbReference type="GeneID" id="3638454"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307730WA"/>
    <dbReference type="CGD" id="CAL0000182523">
        <property type="gene designation" value="WOR4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07730W_A"/>
    <dbReference type="eggNOG" id="ENOG502S48N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642486_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADX8"/>
    <dbReference type="OMA" id="NDQGSPK"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="CD-CODE" id="1E246C77">
        <property type="entry name" value="Transcriptional condensate"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044403">
        <property type="term" value="P:biological process involved in symbiotic interaction"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007618">
        <property type="term" value="P:mating"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900239">
        <property type="term" value="P:regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF4">
        <property type="entry name" value="FUNGAL N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000182523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="401" mass="45319" checksum="6E08F8AADC0A45A7" modified="2005-04-26" version="1">MSSDKPEQEILDPKDSKNASLNSTTKKSQDSKLMLPPLGVKSEQQQPQQQQQTPLYGQQGSPQVQTQPQFQADYSYANYQPQAQFYDPYQRQVIMQQANFASPSQYPIQQPYSFANGMTNMAQFHPQTLTSHSDFDQQQMQQSTQPSQQVQVQVQIQPQSNSNSFPAEQKRGRRFRRRFNQIERKYPCSFPGCQKSYGSLNHLNTHIVTKKHGHRKSKADFQHSLQSKEENKPSEISQYVQPSNDYTAGNYWYGYAPHLRSTTSTTSSQSDSFNSQQIPQQPQQQQQQQPQQQNNSNNYLYYQGFQQPITNATTVSGATPATSTLTPAGTASASLSHQPQIQNPASASTVPQQRMVMGNMGYYQQQGAPQYFPAPQQSLLGINDVDSRNQIDDNKPTQPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEC3</accession>
    <name>Q5AEC3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C303470WA</name>
        <name evidence="10" type="ordered locus">orf19.7978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720040.1">
        <property type="nucleotide sequence ID" value="XM_714947.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEC3"/>
    <dbReference type="SMR" id="Q5AEC3"/>
    <dbReference type="FunCoup" id="Q5AEC3">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AEC3"/>
    <dbReference type="GeneID" id="3638306"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303470WA"/>
    <dbReference type="CGD" id="CAL0000178220">
        <property type="gene designation" value="orf19.7978"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03470W_A"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="InParanoid" id="Q5AEC3"/>
    <dbReference type="OMA" id="IVTGMPT"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006540">
        <property type="term" value="P:gamma-aminobutyrate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000178220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="491" mass="54385" checksum="E4BDFA4197581B6A" modified="2005-04-26" version="1">MAPKLNNPNLFQNKPFINGQWYDSKSTSTFKVYDPATQELIIELPDQTPEEIDEAIAITHKAFQTYQRTPVYERAKWLRRMYELMIENLQDLATLITWENGKCLADALGEIKYAASYFEWFSEECKRNYGHTIQPSNQNNKVITYKQPVGPVGLLCPFNFPSAMGARKAAPALAAGCTCILKPDGQTPLSSLALAYLAQQAGFPDGCFNVVLTSVTNTPMCGLKFCQSPKLKKISFTGSTNVGKLLMQQSSSTLKKLSMELGGNAPIIVFNDCNLDLAVDQSITSKFRSLGQTCVCANRIYVEKGVYDEFCNKFVEKVNQFKIGNGFEPGVTHGCLINTKAIEKVEDHVQDAVEKGAKLIVEGGRLPQLGENFYSPSVVKDVTQDMKVVKEETFGPLAAIIPFDSKEQVLQWCNDTPYGLASYIFSENLNTVWYMSEFLENGMVSVNTGLFTDAALPFGGVKESGFGREGSLYGMDDYTVIKSITLGNVYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2025-04-09" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEI1</accession>
    <name>NUZM_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase subunit NUO2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NUO2</name>
        <name type="ordered locus">CAALFM_C302940CA</name>
        <name type="ordered locus">orf19.7919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="Cell. Microbiol." volume="17" first="1350" last="1364">
            <title>Fungal-specific subunits of the Candida albicans mitochondrial complex I drive diverse cell functions including cell wall synthesis.</title>
            <authorList>
                <person name="She X."/>
                <person name="Khamooshi K."/>
                <person name="Gao Y."/>
                <person name="Shen Y."/>
                <person name="Lv Y."/>
                <person name="Calderone R."/>
                <person name="Fonzi W."/>
                <person name="Liu W."/>
                <person name="Li D."/>
            </authorList>
            <dbReference type="PubMed" id="25801605"/>
            <dbReference type="DOI" id="10.1111/cmi.12438"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="J. Proteomics" volume="127" first="340" last="351">
            <title>Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host-pathogen interaction.</title>
            <authorList>
                <person name="Gil-Bona A."/>
                <person name="Parra-Giraldo C.M."/>
                <person name="Hernaez M.L."/>
                <person name="Reales-Calderon J.A."/>
                <person name="Solis N.V."/>
                <person name="Filler S.G."/>
                <person name="Monteoliva L."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="26087349"/>
            <dbReference type="DOI" id="10.1016/j.jprot.2015.06.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Fungal-specific subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:25801605). Plays a role in cell wall integrity and is involved in osmotic and oxidative resistance, yeast to hypha transition, and virulence via providing the ability to damage and invade host cells such as oral epithelial cells (PubMed:25801605, PubMed:26087349).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1 2">Reduces mitochondrial NADH dehydrogenase activity (PubMed:25801605). Leads to growth defects on glycerol and oleic acid, and shows reduced oxygen consumption rates (PubMed:25801605). Decreases the mitochondrial membrane potential (PubMed:25801605). Shortens the chronological life span (CLS) (PubMed:25801605). Leads to sensitivity to both cell wall-damaging agents calcofluor white and Congo red, as well as to thermosensitivity (PubMed:26087349). Also increases the sensitivity to oxidative stress agents H(2)O(2) and menadione, as well as to osmotic stress agent KCl (PubMed:26087349). Impairs the yeast to hypha transition (PubMed:26087349). Causes significantly more damage to the host macrophages and results in significantly less damage to host oral epithelial cells (PubMed:26087349). Results in avirulence and reduced fungal growth in a mouse model of systemic candidiasis (PubMed:25801605).</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719984.1">
        <property type="nucleotide sequence ID" value="XM_714891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEI1"/>
    <dbReference type="SMR" id="Q5AEI1"/>
    <dbReference type="STRING" id="237561.Q5AEI1"/>
    <dbReference type="EnsemblFungi" id="C3_02940C_A-T">
        <property type="protein sequence ID" value="C3_02940C_A-T-p1"/>
        <property type="gene ID" value="C3_02940C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638381"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302940CA"/>
    <dbReference type="CGD" id="CAL0000195285">
        <property type="gene designation" value="NUO2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02940C_A"/>
    <dbReference type="eggNOG" id="ENOG502S2AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081626_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AEI1"/>
    <dbReference type="OMA" id="GYPCRTF"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000459488" description="NADH-ubiquinone oxidoreductase subunit NUO2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="25801605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="26087349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="25801605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="194" mass="21549" checksum="620828ABB166941B" modified="2005-04-26" version="1">MSGGPVPVWKKYTTRPQGIWEKIRQLLVLVPNRSSGNPLVSLFRQVPPGERIKEAQNYKDPVTIPAGDIKGNPYFKRDYRRNYPQVHTFNQTKISGLLNLGSESNPRISIGEKGNKELAVFTNGQDVSLASTLKSVPASVVKGEVLGKSGEPIVAPSLNKFKWEILPEPVHGMYSEAYPCRIFTEKKVRSQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AF99</accession>
    <name>Q5AF99_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C402880CA</name>
        <name evidence="12" type="ordered locus">orf19.10223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720459.1">
        <property type="nucleotide sequence ID" value="XM_715366.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AF99"/>
    <dbReference type="SMR" id="Q5AF99"/>
    <dbReference type="FunCoup" id="Q5AF99">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AF99"/>
    <dbReference type="GeneID" id="3637907"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402880CA"/>
    <dbReference type="CGD" id="CAL0000178770">
        <property type="gene designation" value="orf19.10223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02880C_A"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AF99"/>
    <dbReference type="OMA" id="TIISAKC"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
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        <source>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
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        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
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    </dbReference>
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        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
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    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000200680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="153" mass="17384" checksum="303DA3F9DECE2CBD" modified="2005-04-26" version="1">MTEDTVQVYVYDLSQGLARVYSPMLLGISIDAIYHTSVVIRNKEYYLDQGIKVNSPPGHTKYGTPIEVLEIGTTGVDDELLNDFINELKNHDEMKYHAVNYNLFTNNCNHFTDVVIDFLCGKNLEDRILKLPDTVLNTPNGQLLQQMLGQNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJX7</accession>
    <name>Q5AJX7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C505440CA</name>
        <name evidence="4" type="ordered locus">orf19.11525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721951.1">
        <property type="nucleotide sequence ID" value="XM_716858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJX7"/>
    <dbReference type="SMR" id="Q5AJX7"/>
    <dbReference type="STRING" id="237561.Q5AJX7"/>
    <dbReference type="GeneID" id="3636431"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505440CA"/>
    <dbReference type="CGD" id="CAL0000199819">
        <property type="gene designation" value="orf19.11525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05440C_A"/>
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    <dbReference type="InParanoid" id="Q5AJX7"/>
    <dbReference type="OMA" id="NKCIRFG"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
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        <property type="entry name" value="ACTIVATOR OF SKN7 PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF20400">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="428"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000199819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="752" mass="85505" checksum="5F15C619CEE9BBCF" modified="2005-04-26" version="1">MSSPPPFHFEKQSVLPSSDPKSPFFCNLPFYESKPIDHLIDFFKYWKYFIKAILYYFKEIALVKELEANLNYQLINAVQFPGFKDLPNKILQEISASNNAGVVSPKNGTPTNELKKTLSNTSIATTTSEKRPGLFKQKSNGGNNPFLKSNPLHKRNSSLTSIKSQSGPPTPPPTQPSGFVLPPAPKAEPTNDVKIPASFFPDDSIYTNFPSLLLSSHHTLFNNSFKLTKELNSKLIPRLEMLLKQLSHKIKEIKTSLKNDSFANKDLLKEISKTGQALRRYTSAVELYCGEVPVTKKYVDDEEELAALDDPLLVKLQVDYRLKNQLIMENYMFASYLNLQGIARDLFTYILKELHWVIDKFGKLHFNSEYHQFLKTKVSNSSTHDWQYFISHNPCFINTAESTEENPKRENRTFKAIQLPYDNSVQNKCIRFGMMYKKSKVMKSYTRCYYVLSCNYLHEFKFDEDVNVTGKKSKDKIGGFIGHDTEPIKSYNLNEYTITPKNDSSYKFVLSKNNTKSKRTFKCATESDYNNWFRDLSELLKFGSDHYARYSFIQKKVHLYRASTVPEGKAGLKLDLGNASTPALTGMFTPSIRTPKQSPSEDNPFENMLSDIPTHSPTGTPKVLTPEQSSTNLVAVDTQHHEYLKLQNAFLHQQQELLDMKMKETSSFDLIQKKLDKIHEHQSPYLSTKGSSDSLNSFVIPSQAVPAAQQVIDDHLKHHSDKPIVFNLGEAADANAEGSTPPIPTVLISENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK98</accession>
    <name>Q5AK98_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C504360CA</name>
        <name evidence="1" type="ordered locus">orf19.11404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721832.1">
        <property type="nucleotide sequence ID" value="XM_716739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK98"/>
    <dbReference type="SMR" id="Q5AK98"/>
    <dbReference type="FunCoup" id="Q5AK98">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK98"/>
    <dbReference type="GeneID" id="3636483"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504360CA"/>
    <dbReference type="CGD" id="CAL0000194158">
        <property type="gene designation" value="orf19.11404"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C5_04360C_A"/>
    <dbReference type="eggNOG" id="KOG3109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AK98"/>
    <dbReference type="OMA" id="YPHHVNL"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000194158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="287" mass="33270" checksum="4A695C313E3FE566" modified="2005-04-26" version="1">MTVSNSQTVNYINPELTEAENAKPGRHVNLPFGYGPIPQQFKNKKIFFFDIDNCLYPRSTRIFEMMQVKIHDYFKKSLSLNDEDAHNLHMNYYKTYGLAIEGLVRNHQVDALDYNSKVDDALDLHSVLRYDSDLRKTLIAIKESSKFDYFWLVTNAYKNHALRVISFLGIGDLFDGLTYCDYSKDPIICKPMPEYFYNCFELTQLDYQNSAVLSEQYFIDDSELNVKEAKRLGVGHVIHYVELSSDVEKLKAKPDFEEFYGTGDNSDPNKIWILNKIQNLPNLIGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKV6</accession>
    <name>Q5AKV6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">PDX1</name>
        <name evidence="13" type="ordered locus">CAALFM_C113830CA</name>
        <name evidence="12" type="ordered locus">orf19.12488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722224.1">
        <property type="nucleotide sequence ID" value="XM_717131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKV6"/>
    <dbReference type="SMR" id="Q5AKV6"/>
    <dbReference type="FunCoup" id="Q5AKV6">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AKV6"/>
    <dbReference type="GeneID" id="3636128"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113830CA"/>
    <dbReference type="CGD" id="CAL0000179519">
        <property type="gene designation" value="PDX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13830C_A"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AKV6"/>
    <dbReference type="OMA" id="NRFEVYD"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000017">
        <property type="entry name" value="Pyruvate dehydrogenase complex protein X component, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="11">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000179519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW26985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="417" mass="46059" checksum="8185A99DA0CE8D62" modified="2005-04-26" version="1">MLRAAFTRRTVNQIRAFHGSSIYYAASVFKMPAMSPTMSEGGIVSWKVKPGDTFSAGDPILEVETDKATIDVEAADDGKLWEILVNEGTSGVPVGKPIAFLAEQDDDLSTLEKPSIEDVKQETQAPAPQEKNPEEKTTKKEVKQSAPREVSTGSSVLQKANPNQKLSPAVELLLHENNISNEDAFAKIRASGPKGRILKGDVLAYLGKIDTGVVVELTEFLKSREHLDLSKIMLAEPSKTEESTESKSSKEEKAKVEKPKPKNILSVELTSNLGEDISQSKFKFAFEKSISAAIRQTYASKFPQFAQSPTASSIYDKYDVFDEILSAPVTKNRFEVFDIKYKFYGEESSKNKVSADSFDELLGLSTPVQYLETGSSNVNVSFKIKFDDKLQDSKLFVENFENSLLSQIPANKLKITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALW4</accession>
    <name>Q5ALW4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">SMP2</name>
        <name evidence="6" type="ordered locus">CAALFM_C201550WA</name>
        <name evidence="5" type="ordered locus">orf19.9037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722512.1">
        <property type="nucleotide sequence ID" value="XM_717419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALW4"/>
    <dbReference type="SMR" id="Q5ALW4"/>
    <dbReference type="FunCoup" id="Q5ALW4">
        <property type="interactions" value="446"/>
    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C201550WA"/>
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        <property type="gene designation" value="SMP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01550W_A"/>
    <dbReference type="eggNOG" id="KOG2116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002546_3_1_1"/>
    <dbReference type="InParanoid" id="Q5ALW4"/>
    <dbReference type="OMA" id="QDYSMKL"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="PHI-base" id="PHI:8741"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="330"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000195424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="781" mass="88119" checksum="A74351FE2AE08784" modified="2005-04-26" version="1">MQYVGKVGGYVYNQWNSLNPATLSGAIDVIVIEHPDGTLHTSPWHIRFGKFQIIKPSQKKIDLYVNDIKTNLPMKLGDGGEAHFVFEVDDKNHALSHSVLTSPIISPVSSPGSSPVSTAAEPLDDLDLNENTNVEERIKLSDIPSPRSKSPTPSLKTKKAFENAKKITQKLNIPTKFDLNGDLVIDLDGYKPNSQKNIENSDELFQKIFFEEIEGEYSQGEKIKAWEQFISRDENGHYRISNTGEFEGSEMEDDSTAPTTLTTATTTSLNTFSTTSSDSDKTYFKTLRLTSDQLSKMNLHYGENSLKFKASDGNSQVTANLYLWKSTTPIVISDIDGTITKSDALGHVLNLIGRDWTHPGVASLFQEIRQNGYNIVYLTARSVGQADTTRQYLQGVNQDGIKLPPGPVILSPDRTFAALRREVVLKKPEVFKMACLSDIKNLFFEPIEGNEDDNDDDHTPFYAGFGNRITDAISYRSVHIPSHRIFTINPNGEVHMELLELAGYKSSYLHIGELVDQFFPPIRQVSSISSYWNNAQWNDYMQNHRTPSPLGSPRSPGSPRSVMEDFKTDEKFNDVNYWREPLDLDNLTDSDDDVQGLKQAVSEKNDISVKKNEKLSHGLILNQEKEHNNNPELLEKSRSRASTIERPTSGSSFTSPLKSFMMFGKKKDNSKDDDSDYGNEQLADGKLTEEDMEVDDVDIDEEDDDDYTDDDYDEDDYDEDEDDDYEDEEDDEEDDYDDYDDDEEIDEIIVPDSPLLDIDEDNKSGSNSKELSAEDVEKLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANJ0</accession>
    <name>Q5ANJ0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">CMK1</name>
        <name evidence="7" type="ordered locus">CAALFM_C304550CA</name>
        <name evidence="6" type="ordered locus">orf19.13332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723124.1">
        <property type="nucleotide sequence ID" value="XM_718031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANJ0"/>
    <dbReference type="SMR" id="Q5ANJ0"/>
    <dbReference type="STRING" id="237561.Q5ANJ0"/>
    <dbReference type="GeneID" id="3635263"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304550CA"/>
    <dbReference type="CGD" id="CAL0000190479">
        <property type="gene designation" value="CMK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04550C_A"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="Q5ANJ0"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="BRENDA" id="2.7.11.17">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000190479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="415" mass="46810" checksum="6E7DFA33FF44E529" modified="2005-04-26" version="1">MTKTGKFTPWDETTGNKTTTANNTSYILSKKPLGDGSYSVVFECKNTSTGRHYAAKKYTKRLMYGFENMLKNEFKVLNRISLSHSHLLSLIDFFETEESFYLVTDLARGGDLWNKIAEEEKLNEQTTRTITRQLVESVEFLHKHQILHHDIKAENVFFQSKHQDTILLGDFGLAKILQPQEKLHEVAGTLSYMAPEMLDYKIGYDFPIDVWALGVCVYFMLCGYMPFDCDDDEETKDAIRSRKYLFEPSEYWVDVSSEAKDFILACLQVDPQKRLTASQLLQHSFLKINSTKPAITISSPLKRSFSNLSALQRDQIKNILQKVGGVSAPALSHSSSINEKLERGRFDSLNKDATLNGAICPSPECVSIFSSPANSTSVSRDGSGLNIFEESLKWDSSQKKALPLNTLRQGASFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANJ8</accession>
    <name>Q5ANJ8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rax1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">RAX1</name>
        <name evidence="5" type="ordered locus">CAALFM_C304490WA</name>
        <name evidence="4" type="ordered locus">orf19.13324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
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        </reaction>
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    <comment type="subcellular location">
        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000186259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="865" mass="99519" checksum="4E596C2BDA86B602" modified="2005-04-26" version="1">MDTQTGKGVRRRRQELIDADDNEEEEREQITQQGPLKATSTIETAKPTPESNTPPLPLPSPPAPAQHYKRPKSKYYQFKQELEELEIQEDLSPRQQSRLEYLTNKLNNWNRNNNNNNNASQNEYYNLPSLQQSKNDVLHQKQQSFQPPRMNWEDEQFKRADQLILQNDDKIHINDDKEYEFVFDQTQFVNYDDIEELPGNGEEEEEEESGIRDSDSIIGNKYDEVRKSLPVYSYREEFLKIINENQTLIVVGETGSGKTTQLPQYLHEAGYSRNNQVIACTQPRRVAATSVANRVANEMQVKLGEQVGYNIRFDDNCKDGVTVIKYVTDGMLLREFLQDPTLGKYSAIMIDEAHERTLSTEILLSLLKDVMMTTRKDDLKIIIASATINAEKFSQFFNNAPILNIPGRRFPVKIHYTKQPEANYIQAAITTIFQIHMTQPLPGDILVFLTGQDEIETMEEILRDSILKLGDQIDPMIVCSIYANLPQELQQKIFQPTPSNTRKIVLATNIAETSITIDGISYVIDPGYVKQNVYNPTTGMESLVVVPCSRASADQRAGRAGRVGPGKCFRLFTKWSFYNELDSNQQPEIQRVNLTSVILLLLSLGINDLLGFEFMDPPSKEAIIKALNLLYALGALNTQGKLTKTGKKMSEFPLDPVFTKCILTSDKFDNTKQIISIIAMLNESSNLFYRPKDKKELADKRKQEFNDLQGDQFMLLKIWQQWVDSGYSVQWCQDYFIQYKTMKRIKNIYEQLIRLSKKIGIEVNSRHQHRDHLQENTDNNTLLTKCLISGFFNNIVKLSPMGDCYQKLTNGKGGNNTPCYIHPSSCIYKLKPKPKYLLYYELVLTSKEYMRNCIILDEKLIKEYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q9B8D6</accession>
    <name>NU1M_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>NADH-ubiquinone oxidoreductase chain 1</fullName>
            <ecNumber>7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>NADH dehydrogenase subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NAD1</name>
        <name evidence="4" type="ordered locus">CM_00060W</name>
        <name type="ORF">CaalfMp03</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="865" last="872">
            <title>Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.</title>
            <authorList>
                <person name="Anderson J.B."/>
                <person name="Wickens C."/>
                <person name="Khan M."/>
                <person name="Cowen L.E."/>
                <person name="Federspiel N."/>
                <person name="Jones T."/>
                <person name="Kohn L.M."/>
            </authorList>
            <dbReference type="PubMed" id="11208783"/>
            <dbReference type="DOI" id="10.1128/JB.183.3.865-872.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2"/>
    <dbReference type="EMBL" id="AF285261">
        <property type="protein sequence ID" value="AAG59589.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_075032.2">
        <property type="nucleotide sequence ID" value="NC_002653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9B8D6"/>
    <dbReference type="SMR" id="Q9B8D6"/>
    <dbReference type="STRING" id="237561.Q9B8D6"/>
    <dbReference type="EnsemblFungi" id="CM_00060W-T">
        <property type="protein sequence ID" value="CM_00060W-T-p1"/>
        <property type="gene ID" value="CM_00060W"/>
    </dbReference>
    <dbReference type="GeneID" id="802557"/>
    <dbReference type="KEGG" id="cal:CaalfMp03"/>
    <dbReference type="CGD" id="CAL0000201667">
        <property type="gene designation" value="NAD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CM_00060W"/>
    <dbReference type="InParanoid" id="Q9B8D6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000356875" description="NADH-ubiquinone oxidoreductase chain 1">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000201667"/>
        </source>
    </evidence>
    <sequence length="317" mass="34779" checksum="8E1CE069C563E6D3" modified="2003-10-01" version="2">MQYIELLIMFLSVLLAVAFLTVAERKTLGYMQRRVGPNAVGYYGILMAIADAAKLLLKEIVVPTHADKLILFVSPMISLISALLCWSVIPFAPGVTIYDSNYGFILTLAISSVGVFGTLLAGWSANSKYSLLGSIRSTAQLISYELVLTTIILLCILIGGTMNVSKYIEIQQAIWYGIPLLPLAIIFFIGCVAECARPPFDNVEAESELVSGHMTEYSSSIFVLFFLSEYASILFLSTLTAILFMGGGTGIILGLKANLFAFTYIWVRATLPRVRYDKLINLCWMIFLPILFGSAIAVPAYLYALDAIIILYRPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCB0</accession>
    <name>A0A1D8PCB0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LRO1</name>
        <name evidence="4" type="ordered locus">CAALFM_C100870WA</name>
        <name evidence="3" type="ordered locus">orf19.13439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718980.2">
        <property type="nucleotide sequence ID" value="XM_713887.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCB0"/>
    <dbReference type="SMR" id="A0A1D8PCB0"/>
    <dbReference type="FunCoup" id="A0A1D8PCB0">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCB0"/>
    <dbReference type="ESTHER" id="canal-q5abf2">
        <property type="family name" value="PC-sterol_acyltransferase"/>
    </dbReference>
    <dbReference type="GeneID" id="3639356"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100870WA"/>
    <dbReference type="CGD" id="CAL0000182687">
        <property type="gene designation" value="LRO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00870W_A"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCB0"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
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        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
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        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
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    </dbReference>
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        <source>
            <dbReference type="CGD" id="CAL0000182687"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ordered locus">CAALFM_C100840CA</name>
        <name evidence="2" type="ordered locus">orf19.13443</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713772.2">
        <property type="nucleotide sequence ID" value="XM_708679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCQ8"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PCQ8"/>
    <dbReference type="GeneID" id="3644594"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102210WA"/>
    <dbReference type="CGD" id="CAL0000196833">
        <property type="gene designation" value="orf19.11162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02210W_A"/>
    <dbReference type="eggNOG" id="ENOG502RQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCQ8"/>
    <dbReference type="OrthoDB" id="4024635at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
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        </location>
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        </location>
    </feature>
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            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000196833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="570" mass="64453" checksum="1D7C84345FABD762" modified="2017-01-18" version="1">MKKSNSKQLLTTLDLPPIIPASITTLDFDHAVNSYQPGNYNPEDLPDKIPIINESTGSFRRFIRRAKSTRIKKNNDKRRIVSAPPGTYIGKELPDIPSNMPTTPITIIAPKDRTNRKPLYTNPPRTISLINENIPYPVLTTPNYNPHQIKLVVDEPHLKLEPKLTNDSETNSIGTDSILSTKSIDIPVAIHDDAKVTVTHNCNSSSSDNDSLVDSLFSKEEEQEGDQIDPVTSHEEHEIESSTLVLPKMRKKSSPPPSSSSDKIGHSQTKSSSHQINTKSLGYCLDTPNVYKESRFPSVPSHIKVPKQVNESGGGGGATHKNIENSKTDKRRSLSDFTHMKHVLTKLDHHDNNSQEVKHRSLISFSQLKLGSKEDINKKTDKESDKRRSWYVDFIPHGNSNRDDAKQQKHRAVSNIVVSKTKQLEPTTFSTTTTTQDKYNRKKRLSYSDFIRPQVRSVSTPDDTRAKKILPPLPPKHDINNNNNYTQSKNVIEPRYYINTYIKPRRNKETNTNINIIPKTSTCNNKNQLYSTTNKPTMGKSLPPLPPPSPPKIHGEYYRTNRFGERSHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCV9</accession>
    <name>A0A1D8PCV9_CANAL</name>
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        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
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    <gene>
        <name evidence="5 6" type="primary">PDE2</name>
        <name evidence="6" type="ordered locus">CAALFM_C102840WA</name>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        </source>
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            <authorList>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="4 5" key="2">
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Nantel A."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="1075"/>
            <end position="1381"/>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE87</accession>
    <name>A0A1D8PE87_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">NOT5</name>
        <name evidence="16" type="ordered locus">CAALFM_C108300WA</name>
        <name evidence="15" type="ordered locus">orf19.12573</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_712551.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="3640763"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108300WA"/>
    <dbReference type="CGD" id="CAL0000183176">
        <property type="gene designation" value="NOT5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08300W_A"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE87"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="497"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
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        </location>
    </feature>
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        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
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            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="365"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04065"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000183176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="662" mass="74771" checksum="E97E832031EE89B1" modified="2017-01-18" version="1">MSARKLQQEFDKLNKKISEGLQAFDEIKDKINATESASQREKLENDLKKELKKLQRSRDQLKQWLGDSSIKLDKNVLQENRTKIEHAMDQFKELEKSSKIKQFSNEGLELQSQQKRSRFGDDAKYQEACTYINEVIEQLNGQNEELEQELDSLSGQSKRKGGSSIQSSIDDVKYKIERNNSHISKLEEVLENLDNDKLDPARIDDIKDDLDYYVENNQDEDYVEYDEFYDQLEVDEEDDVEVQGSLAQMAAETEDERRRDEERKREEKEKEKQQQNPPRTSSSVSSSSSSNQNNIGNNTPPATQIKPSVVTVAAIGDQNNNSASSASSTSTPVKKLKPTLAPAPAPPPITSATSYSNAIKAAQTASTSSTSNSSIAHTANDNNNTNKGNRSVSPLASTDNHTHAPAAVSTPVKVLPPGLNHDTSMNSTLRSESSSPLVGHAKVNNNHELQISRSQSPMVSNENKVFSDTISRIVNVAHSRLNDPLPLQSITGLLETSLLNCPDSYDAEKPRQYNPVNVHPSSIDYPQEPMYELNSSHYMKKFDNDTLFFCFYYGDGIDSISKYNAAKELSRRGWVFNTEFSQWFSKDSKNGGKNRSMSVIQREEENGNIIGDNSNGNEELREKIDDNGGIPSNYKYFDYEKTWLTRRRENYQFATENRQIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PED2</accession>
    <name>A0A1D8PED2_CANAL</name>
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        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
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        <name evidence="6 7" type="primary">SWI6</name>
        <name evidence="7" type="ordered locus">CAALFM_C108670WA</name>
        <name evidence="6" type="ordered locus">orf19.12188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723412.2">
        <property type="nucleotide sequence ID" value="XM_718319.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PED2"/>
    <dbReference type="SMR" id="A0A1D8PED2"/>
    <dbReference type="FunCoup" id="A0A1D8PED2">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PED2"/>
    <dbReference type="GeneID" id="3634932"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108670WA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_08670W_A"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PED2"/>
    <dbReference type="OMA" id="WIPYDKA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:SBF transcription complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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    </dbReference>
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        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
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            <end position="221"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000183437"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="729" mass="82490" checksum="8A89563953D9941D" modified="2017-01-18" version="1">MDSPIHIGDLTTQSIQQKLFETHINNNNKNKTINNNCALLSTIYSSIYSGVKTIQLTMKLDSDKNNNNNNNNNDLKFDNKSHGEIIVLRRVQDSFVNVTQLFQILIKLEVLPTSQVDNYFDNEILSNLKYFGSSSNTPQYLDLRKHQNIYLQGIWIPYDKAVNLALKFDIYEITKKLFLVDVHDFDKLPKANKRLYEEDANSDSDILDSPSKKQKLDKKSKKDLLSNGKAITKKLIASSVSQNSNYPFTLPAVIIDNSNSEIANDIKVKLGDVFKRDDEKPDGISFEDVKSAFADALSRYTPETIIDIPLDSKGQTALHFASTLASLNLVSSFIELGLNSPIRGNNAGESPLISCIQVTNSMEKGNFTKILSNWLYPDIWLLDKRKRTVFHHLTLQIDKNDSFRFYTTKILEYIISDNNQNLLDFRANILNAQDEDGNTALHLAIEKDSKWFIKVLVDLGADTSISNKRGTKPSDFEIIRDLGSIENDDQIFDLISTGLEFLNKRLEIGGEKLPEVESPKVVTTPKLIDQEGSSSSGKIFNSIQQLLSNTNVEYENILNSKREQIKQLDRALHDATIVTANNRFNTKKITEKLINLDNLKLQVANVTDKLALSKQELNEEIDDTKEYDADAPFIIPQIYDKLKKGKDPIQDLKTDDYLLSQLQPAPILKARIQAYKDINSKLEKELKTLVDYSDLTSKFKKVVSICTNVGVNEVDEFLDGLLEAVEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEG8</accession>
    <name>A0A1D8PEG8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Spermine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">TPO3</name>
        <name evidence="10" type="ordered locus">CAALFM_C108790WA</name>
        <name evidence="9" type="ordered locus">orf19.12199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
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                <person name="Federspiel N.A."/>
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                <person name="Dungan J."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW26681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_706122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEW3"/>
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    <dbReference type="STRING" id="237561.A0A1D8PEW3"/>
    <dbReference type="GeneID" id="3647191"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110520WA"/>
    <dbReference type="CGD" id="CAL0000185090">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000185090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW26681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70599" checksum="C3BCDD21B221EBB6" modified="2017-01-18" version="1">MTRAKNNADFFTKLAKLPPKVITIIIDELPKCILAELLYFPSIREVVASTILSNVNITEGLQRHGWNYEPDVGYADCNCVSFNIEFGNLKKGINQWNIYPKVFHMKGLSQFVDVLLTCPELLTKASSVNSTFSGLEDTEVEILEKLLMDSNIKFDYLSLSEFPDPITLSPIVKNISLLNTTLISYVIPGVKKLDIVFSNGNEEGQNYVFASDLEELTIKDDRFTQLNLPPNLRKLSIESSLGSVNIISKELVNLEYLQLKELKIASFDETGITAPNLKTLNLENCQNITDFIGLRRFQKLKYISLKGCVFPAGLLEEGLFPELEIFEYSGKDFEPESEYDGPLPLPANLKHVSIKWASSVIIDLNTFVLPSRLKHLELWDIRFSQGHLQFNEDLEYVRIRTRAIRFPGDFRIPPLVKHFQIKATHLCFYKPDFMYHLPDGLNNLQLVCPDLGRMDGLDKIVQWPESLKVFRMHYLGLNSHSLQLWNFKESNLEEIDFRGGALGQLNADALPTSLKVLTMKNLRIEELVGSFGNLKKLEKLILGCNDIKYVSFLEFPSLKFLDLGYCKFDLIPPVTVMFLNQKLKELKLYSKTMDVTVSKQDICLDRNFKRVKRDFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF54</accession>
    <name>A0A1D8PF54_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">PHO84</name>
        <name evidence="10" type="ordered locus">CAALFM_C111480WA</name>
        <name evidence="9" type="ordered locus">orf19.8269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713038.2">
        <property type="nucleotide sequence ID" value="XM_707945.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1D8PF54">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PF54"/>
    <dbReference type="GeneID" id="3645348"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111480WA"/>
    <dbReference type="CGD" id="CAL0000178178">
        <property type="gene designation" value="PHO84"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11480W_A"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PF54"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="PHI-base" id="PHI:8286"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048249">
        <property type="term" value="F:high-affinity phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097079">
        <property type="term" value="F:selenite:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097080">
        <property type="term" value="P:plasma membrane selenite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033660">
        <property type="term" value="P:symbiont-mediated suppression of host resistance gene-dependent defense response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000421">
        <property type="entry name" value="Inorganic phosphate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000178178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="545" mass="59444" checksum="E91CA8EFDDB3B8B1" modified="2017-01-18" version="1">MKYPKVXGKTAFKDYLGKFADVEDPLERRRLALEEIDKAGFGWTQVKMILIAGVGFMTDSYDIFAINLSMNMLQYVYWNGTIPDSTTTLIKVSTSVGTVIGQISFGSIADKVGRKKIYGLELIIMIFATLFQCTLGTSPAINFVAIFSTIRILMGIGIGGDYPLSSIISSEFSTTKWRGAIMAAVFSNQGLGQVFAGIVAMICVAGYKDDLIIANKGSECVGRCRKAADQMWRIIVGFGCVPGCIALYYRLTIAESPRYALDVDEHDDLEKVADAEAAIDVHAQEIAPPKASFKDFCSHFGQWRYGKILLGTAGSWFMLDVAYYGLGLNTTTILQTIGYAGQSNVYEKLYNSAAGNLILVCAGSLPGYWVSAATIDTVGRKPIQMGGFILLTIILCIMGFGYHKIGNHGLLGLFVIAQFFQNFGPNTTTFIVPGECFPTRYRSTAHGLSAAAGKVGAIIAQTCIGTLVNHGCSKENKNCFLPHVLEIFALFMLLGIGLTFLIPETARRTLEEISETCHGEVDTTKLGRDRFATQEEPYDSEEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF62</accession>
    <name>A0A1D8PF62_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">PLD1</name>
        <name evidence="11" type="ordered locus">CAALFM_C111590WA</name>
        <name evidence="10" type="ordered locus">orf19.8753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
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            <taxon>Fungi</taxon>
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            <taxon>Pichiomycetes</taxon>
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            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="5 6" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <begin position="1"/>
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        </location>
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        </source>
    </evidence>
    <sequence length="491" mass="51859" checksum="7B43517DA149833E" modified="2017-01-18" version="1">MTLRNQAMPALHPTLLVILLYISLTHALSLSRCSSTNLGGEKTSSEFMSNGLCRDTCSKDGYAVAVLSGNDCYCTNDVPADTTDMSNCEIGCPGYKDQENCAGDGYFGYLIIGQPSATVGGETSTSKSTQSSTSTSTSTSSTSTSSTTSSSSSTSTTSSSSSTSTSTTSEPSSSISPATTMVTKTTQITETHRSSNIVQVTQYSTEVLTVSPSTTSKSSTSSSSKSSSQTPIVSTKIEQTTAYSIKTVNGTQTQEIKTLYITQFTTQSTSDSTTGTTSFESASISNLRSQDASVAPTSSVPSSSTTDSPKTNKNAFFDDKGKVAGTFTAVGIVVVGIVGAMLYCCCCFGGAGGRHNDHDGYSDEENQYSSDELSVNHATVVAPYSKQSSFSTLKRDSSSKTLFAYFTGDNTNKESGVNRSSSRRKLMSRRSSQMSSSPNNNPEADGGAMFPINEIDSRLDPDTMFLNQNFSNKSLGDNQDYSRKLKITNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFX6</accession>
    <name>A0A1D8PFX6_CANAL</name>
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        <recommendedName>
            <fullName evidence="4">DNA damage-inducible protein 1</fullName>
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        <name evidence="9 10" type="primary">DDI1</name>
        <name evidence="10" type="ordered locus">CAALFM_C114420WA</name>
        <name evidence="9" type="ordered locus">orf19.7258</name>
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    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
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        <text evidence="3">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000199868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="323" mass="35928" checksum="2D006002CFF3A9EC" modified="2017-01-18" version="1">MQLTISLDHSGDIISVDVPDSLCLEDFKAYLSAETGLEASVQVLKFNGRELVGNATLSELQIHDNDLLQLSKKQVADDTQISDRIEMIRNQVLADANAREQVRLTQPNLYDALNDPARFRGIMMEQVSQLSQSSNSQQAELLRLQQDPDNPANQKRILELIREEAIEENMNLAWEISPESFTSVNMLYIKVKINGVEQVALVDSGAAITTISEAIAEEVGLTRLIDRRFQPQAVGIGTQTVAGKIHSAPIEIGDSKIELPCSFHVVETSVGILFGLDMLRRHRCTIDLERDVLVIGKHIEAKFLSESEVPRKSLGGNIFQREN</sequence>
</entry>
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    <accession>A0A1D8PFY6</accession>
    <name>A0A1D8PFY6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C114530WA</name>
        <name evidence="2" type="ordered locus">orf19.7271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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    <sequence length="1690" mass="193539" checksum="9E18B1808DB81F83" modified="2017-01-18" version="1">MNRQPTREDIQRAIQRWHQMKQQYGDQVQLNPEFVKLTKFLNTLKMQQQRFQQQYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSLNHSQQSPLLQNAQGQTPQQPPTPQQFSNFNQNGYNGQQFSSQVHSPAIGGSLSTSGHGTPLVTNANLMTGKKNTRTPNAQFGNQTAAGTPLQQQQQQPFPHGNNSNPMLNQTAQQPPQSQQRQQNQPPSPQSAFTNQQFQLLKSQLQAFKYFVRAPGQGQGQIPQNLIAYVSNPSSAMANDMYLPAVNRPQTNGMDRTMQMPQSIPSQPQQYALQQQNDLSNSNPKSTGGTPEIPEKKKGKRGPKPKNPKKPTKKQLREEEQRLALEKQRQELEQNRLKSSAPQAFPPQAGLQGQAPFPPQPPQQSQQHVPQPPPASTSSSPPGGLPQSQPQPQQQQQQPSRPITKPATPQPLFPDPSPPVNIKSVVPDKANNKKVIIPVTKPNIEVDTFELFDIISDEVKDIPFNTLYAPQSRFQIPSFLPDGINMEDIYVNREGYMQITIEQEKERLRKQIDSLNEKDTEKKLELETQLSQLELIPYQKDLRGKVLIQSWFGKSLLPNSHPNFLARFSSLSMDSVHMTTDLYRLQLESMMREQNKKHGKTIEEIINFSDRSSIKAVKKSDRLSRFMTKINNFHNQTAKEEQKKLEKMAKQRLQALKSNDEEAYLKLLDHTKDTRITHLLEQTNQFLDSLALAVQSQQKEAQDNLAYSGRAIEPASVEPLDDEKREKIDYYNVAHRIKEEVTKQPSILVGGTLKEYQLKGLQWMVSLFNNHLNGILADEMGLGKTIQTISLLTYLVEVKKIPGPFLVIVPLSTVTNWNLEFEKWAPSIKKITYKGTPNQRKVMQHDIRTGNFQLVLTTFEYVIKDKGLLGRIKWVHMIIDEGHRMKNANSKLSETLTQNYHSDYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGGQDKIELTEEETLLVIRRLHKVLRPFLLRRLKKDVEKDLPNKVEKVVKCKSSALQSKLYQQMLRYNMLYAGDPANGSVPVAIKNANNQIMQLKKICNHPFVYEEVENLINPNIETNDQIWRVAGKFELLDKVLPKFKATGHKVLIFFQMTQIMNIMEDFLRFRGMKYMRLDGGTKADDRTDLLKSFNAPDSDYFCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITENSVEEMILERAHKKLEIDGKVIQAGKFDNKSTAEEQEAMLRALIEKEDERRQKGGTDEEEEDLDDDELNQIIARNENELVVFRKMDEERYLATKNAPYPSRLYTEEELPEIYKIDPEELFKKEDVASEEYGRGARERKILQYDDNLTEEQWLKKIEGMVSDDDDDNDDGDGNVDMSDSEMEAKPKKPKGRRGRKPKVARVEDEESQTESDVISVKRQFPEDADDFIPPKRQKSATPGGTTTSGRGRGRGRGRGRGRGRGRGRGSLLSRYTPSVDPLTADERSTLQNQIENILGLIINYKNEHDRVLSELFLVKPPKRFYPDYYVLIKHPIALDVIKKRTASKSYSKIREFLEDIHLMFTNAKIYNEEGSIVYQDAAFLERLSMDKFKELSANLSEDEINKILDFAEFDEMFSLKPLVPSTAIKHPIEAKLEKIDKGEAIDSPLLNASTTAGTEESTPANFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGQ6</accession>
    <name>A0A1D8PGQ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uga6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">UGA6</name>
        <name evidence="8" type="ordered locus">CAALFM_C202850WA</name>
        <name evidence="7" type="ordered locus">orf19.13242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715361.2">
        <property type="nucleotide sequence ID" value="XM_710268.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGQ6"/>
    <dbReference type="SMR" id="A0A1D8PGQ6"/>
    <dbReference type="STRING" id="237561.A0A1D8PGQ6"/>
    <dbReference type="GeneID" id="3642975"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202850WA"/>
    <dbReference type="CGD" id="CAL0000175241">
        <property type="gene designation" value="UGA6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02850W_A"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGQ6"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015185">
        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015812">
        <property type="term" value="P:gamma-aminobutyric acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000175241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="544" mass="58993" checksum="E14D4AD039BCF9A7" modified="2017-01-18" version="1">MRSITSRTEDHLHNVISHRSEVRSIDPQHNAGDVELLAQIGYKQELNRHYSTFQVFGIAFSIMGLLPSISSVLSIGLESGPAGLVWGWISASIFILCVGTSLAFLGSAIPTSGGLYYYTNYYCPDAFRVPLSFMIGCSNSLGLIGGLCSISYGFAVQVLSAVYIQQDGAFEITRAKCYGIFVACVVSNAIICCLATKQAALLQTISIIVNVFLVLLFLIAVPVGTGHGFNSASYIFGTLINNRDYGTAWSFFLSWLPAIWTIGSFDSTIHCSEEAKNAQRAIPVGIIGSISACGILGWAICIVCAACIKDGDVSRVLQSDTGSAMAQIIYDALGKKWAVAFMSLIAVGQYLMSVSEMIALSRQIWSFARDDGLPVVYNFVKYVNPKIKVPIRASIFAGVLSTLVGLLVLIGDAGSGALFSLAIASLQLSWGLPVLLVLLPYGRRKFISGPFHFGFKTNTAINLVTICWSVYAIVLSMFPDSRKVDKASMNYTVVINVGVWLLALIYYFVWGYRFYSGPKSNLDKDDDVVFGTEPEVVAIGEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGT5</accession>
    <name>A0A1D8PGT5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldehyde dehydrogenase (NAD(P)(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ALD5</name>
        <name evidence="8" type="ordered locus">CAALFM_C202970CA</name>
        <name evidence="7" type="ordered locus">orf19.13228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715347.2">
        <property type="nucleotide sequence ID" value="XM_710254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGT5"/>
    <dbReference type="SMR" id="A0A1D8PGT5"/>
    <dbReference type="FunCoup" id="A0A1D8PGT5">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGT5"/>
    <dbReference type="GeneID" id="3643026"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202970CA"/>
    <dbReference type="CGD" id="CAL0000188934">
        <property type="gene designation" value="ALD5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02970C_A"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGT5"/>
    <dbReference type="OMA" id="WSNTFNK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
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    </dbReference>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000188934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="499" mass="54011" checksum="65A83AC2826D0D05" modified="2017-01-18" version="1">MFKKALPLVSKLTTPKGITYNQPLGLFINNEYVHPKQQKTFEVISPSTEEKITDVYEALEEDIDTAVEAAQAAYHNGWAQGPPEQRSKVLFKLADLIEENAELLAQIETWDNGKSLQNARGDVALTAAYFRSCGGWADKILGSQINTGNTHFNYTQRVPLVCGQIIPWNFPLLMASWKLGPVLATGSTTVLKTAESTPLSALYLSQLLVEAGMPKGVINIVSGFGATAGAAIAKHPKIEKVAFTGSTATGKIIMKLAAESNLKKVTLELGGKSPNIVFNDADLDKTIQNLIVSIFYNSGEVCCAGSRLLIQSGVYDQVVEKFKEAAESVKVGNPFDEDTFMGAQVSDVQLSKILKYVESGKSQGATVVTGGARADGKGYFVKPTIFADVKKDMDIVREEIFGPVVTLIKFDTVDEAVELANDSDYGLAAGIHSADVNKCIDVANRVKAGTVWVNTYNDFHPMVPFGGFSASGIGREMGEEVLHEYTQVRAVRMKINPPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH21</accession>
    <name>RL36_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL36</name>
        <name type="ORF">CAALFM_C203960WA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="AJ=1-99"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
    <dbReference type="PDBsum" id="7Q0R"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH21"/>
    <dbReference type="EMDB" id="EMD-13737"/>
    <dbReference type="EMDB" id="EMD-13741"/>
    <dbReference type="EMDB" id="EMD-13744"/>
    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PH21"/>
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        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH21"/>
    <dbReference type="EnsemblFungi" id="C2_03960W_A-T">
        <property type="protein sequence ID" value="C2_03960W_A-T-p1"/>
        <property type="gene ID" value="C2_03960W_A"/>
    </dbReference>
    <dbReference type="KEGG" id="cal:CAALFM_C203960WA"/>
    <dbReference type="CGD" id="CAL0000177209">
        <property type="gene designation" value="RPL39"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03960W_A"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH21"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456504" description="Large ribosomal subunit protein eL36">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="99" mass="11067" checksum="CFE16D476375F6F7" modified="2017-01-18" version="1">MAKSGIAAGVNKGRKTTAKEVAPKISYRKGASSQRTVFVRSIVKEVAGLAPYERRLIELIRNAGEKRAKKLAKKRLGTHKRALRKVEEMTQVIAESRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH73</accession>
    <name>A0A1D8PH73_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C204620WA</name>
        <name evidence="11" type="ordered locus">orf19.11964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712915.2">
        <property type="nucleotide sequence ID" value="XM_707822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH73"/>
    <dbReference type="SMR" id="A0A1D8PH73"/>
    <dbReference type="FunCoup" id="A0A1D8PH73">
        <property type="interactions" value="1083"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH73"/>
    <dbReference type="GeneID" id="3645438"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204620WA"/>
    <dbReference type="CGD" id="CAL0000196990">
        <property type="gene designation" value="orf19.11964"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04620W_A"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH73"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHV2</accession>
    <name>A0A1D8PHV2_CANAL</name>
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        <name evidence="7" type="ordered locus">orf19.9810</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000200327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="584" mass="64112" checksum="01C7C70329AA7CCA" modified="2017-01-18" version="1">MTTTSSSTNESIRPKNNHTTISTTGVSTTLDQTTTTRFRNNYDDNNNNSVISKDSSTFAYVVNRSKSVLKKYGSFVGPGMLISVAYMDPGNYATGITAGASNEYSLLFIVFLSNVIAIFLQSLCIKLGSVTGYDLARCCREYLPKQLNWVLWFLAECAIIATDVAEVIGSAIALNILLKIPLPAGVVITIIDVLFVLMAYRADTSSMKFVKIFEYAVGALVMVVVVCFAVELSQIHASARDIFRGFVPSKQMFDGNGMTIATSIIGSTVMIHSLFLGSGLVQPRLRDFDVKHGYVNLDDILNKNDQPQFPVIESSTTTPSEKKDDAKNNVKVSMYEKEADYFYHYYKPSYQSIKYSLKYSIVELTITLITLALFVNSAILIVSGSTLYGTEEAIDADLYTIHDLLSRSLAPAVGTIFMVALLASGQSAGIVCTIAGQIVSEGHINWTLKPWLRRLVTRSISIIPCLIISVCIGRNGLGIALNISQVVISILLPPLTAPLIYFTCSKKIMKVELNENDEAIGVTGQEEEVEDEESNDQDTNGSGKKYKYMTNNWITSIVAVIIWFFVSTLNVYAIYEMAKNGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI00</accession>
    <name>A0A1D8PI00_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">GDH2</name>
        <name evidence="7" type="ordered locus">CAALFM_C207900WA</name>
        <name evidence="6" type="ordered locus">orf19.9738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716032.2">
        <property type="nucleotide sequence ID" value="XM_710939.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI00"/>
    <dbReference type="FunCoup" id="A0A1D8PI00">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI00"/>
    <dbReference type="GeneID" id="3642295"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207900WA"/>
    <dbReference type="CGD" id="CAL0000201467">
        <property type="gene designation" value="GDH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07900W_A"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI00"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="674"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000201467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1056" mass="119788" checksum="8145DC2E41936133" modified="2017-01-18" version="1">MTSASLENGVSRLNIYRTTSNTSSQVSLKHDYIDSPFSGKKDQFDQVLDVLDSTGFIPESLIESEAKWFYESLGIDDVFFARSSPEDIASHIHALYSCKVQAYSSFGEQPLISYKREAEDHAVFFDTVDAESYKRNQFEERIDDKYIDPSSTTTNSYRTEYFSAPLNYQSDPILSGVYQQNKELRDQYVRLFFVYKNNYTISEAAANETDLEKIGDKTFLKIASDNTKQLYTSIVKDVINTTGPVIKHFPLEDSEEYRVVIGYKQKTSARYNSALSDLANYYKLQVTRKYVEQFSNGVTIISMYVTSKSRKSPVDLSIYQVIKEASLLYCIPHNYFHDRFIQGELSLQESIYAQSGVIFVTHFLNRLGPEYNKLSSLLDPSKSIEHAEVLNSLKKRLRAETYTQDYIKEVFDNRRDIVRKLYRQFADVHYIRSSMEKTLSYQRLSQITPVGSEEEFEQLLSRECSQNEHHAIVLRALYTFNKSILKTNFYTSTKVALSFRLNPSFLPESEYPERPYGMFFVVGSDFRGFHIRFRDIARGGIRIVRSRSLDAYNVNARNLFDENYNLANTQQRKNKDIPEGGSKGVILLDPGAAQERPQACFEKYIDALIDLLLKQNIPGVKDNYVDLYAKPEILFLGPDEGTAGYVDWATLHARERGAPWWKSFLTGKSPELGGIPHDEYGMTTLSVRAYVNKIYEKLDIDDAKIRKFQTGGPDGDLGSNEILLSRKENYVGIVDGSGVICDPQGLDKQELIRLAKERKMIEHYDKTKLSPQGYVVLVDDMDVKLPSGEVVTSGVAFRNTFHLKLKQQFGVDGVDLFVPCGGRPAAIDTNNVHDLIDEKTGKSVVPYFVEGANLFITQSAKLILEKAGIVIFKDASTNKGGVTSSSLEVLASLSFDDKGFLENMCVDPETKAKPQFYQDYVKDVQKIIVGNADSEFEALWKLKAETGTPFTILSDKLSVAINKLGDELANSKELWNDDIEFRNAVLLDSLPPLLLEKVGIENVLSRVPEAYLKAIFATHLASKFVYSRGIDSNPAKFLEFISSIRKDFIQKGLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI29</accession>
    <name>A0A1D8PI29_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C208260WA</name>
        <name evidence="2" type="ordered locus">orf19.9765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716060.2">
        <property type="nucleotide sequence ID" value="XM_710967.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI29"/>
    <dbReference type="STRING" id="237561.A0A1D8PI29"/>
    <dbReference type="GeneID" id="3642345"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208260WA"/>
    <dbReference type="CGD" id="CAL0000176806">
        <property type="gene designation" value="orf19.9765"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08260W_A"/>
    <dbReference type="eggNOG" id="ENOG502RQBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI29"/>
    <dbReference type="OrthoDB" id="4090363at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000176806"/>
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    </evidence>
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                <person name="Dignard D."/>
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        </citation>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="102" mass="12341" checksum="198099C7CD0A8B56" modified="2017-01-18" version="1">MCHPSFKLLCSYQLNLQNTVEFAERESQKKQWSHVGRVRSANQCWFFFFRDPNRFVYCQEEIHCGQNYCGKSCYCQYYPAITDILQKKILEYLSKKITIQQY</sequence>
</entry>
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            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
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    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_711515.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C305870CA"/>
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    <dbReference type="eggNOG" id="KOG1867">
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    <dbReference type="OMA" id="VECNRCA"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
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        <property type="component" value="Chromosome 3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000188694"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28595.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PKJ1_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="288" mass="33266" checksum="1C0D60278CC2D687" modified="2017-01-18" version="1">MKSFVSKSSLTQIMRHSRPTLVISDWDETITEEDTIKYVAQVPYIKQRQQRVLPPFEKFVESYNQNYTNLKNSFNFPNTTTTSIECSDYLSQQIKFQDELSTVENQSIELIEQSKIFEGLTKKDFQDYVNINHNKIKLRPGFSQFVKRCQNLNIPIIIVSANWTSIFIKQCLANHGLAVDDIITNELSFHSDDEEAKTKMTTTGLWDKSKYTIRTSQDKLDIVKQIQEEKDGLIMYIGDSGTDLLPLLNVDFPCAIKGSRIVEIFDKSGLRDNLNVGTWHDFINIIKE</sequence>
</entry>
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            <fullName evidence="4">XPG-I domain-containing protein</fullName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
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        <property type="protein sequence ID" value="AOW29088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715324.2"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
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        <property type="entry name" value="XPG_DNA_repair_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000192967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="898" mass="102209" checksum="C818C65FE9650D8C" modified="2017-01-18" version="1">MPITSLESYLFERKFANASSIEILQNAVIGIDVEHYLSRIYTFKKEQFLPAIGGAPSSLRDYIKSDLKVFQEFNIKPIFVISGLHTQLEQKYKNNLIEFDTQHVENTWNKVNSKDPYGHGFHHQHSHSHSANIDGFRNLNEPLPIYSMINYIIKFFLEFDIDYMISPYDASFQLSYLYQSGIIDIVYGSTDLLLTKIDKFILGMEFQSKDFRFVNKNKVLKGLNLSERQFLDLCIIVGCGVQPETFPLFSALSNKPPSGGDMPSSSSTSSYGVGGSAIGSGSAPGAPGSGSGPAGPGAGSQLSYFKIGLDILYQYAQFSGDNSSLLGYIITLNNPKLLDLYYKGVCAIRYMPILNQEGYVELYHVAMAKLGLSENIDFLHQEEEVVGGQIQAENQQVKGRNAEVKQTKQGGETDNEKSNADSNTLHRSVRIPNDVHEIISQRLPPELYFYQSMGLLPLALLGSIVKGELIIRAPLEGGMGNKSNESYKNLITSKFYVELLDSQFNLITQFLARYYQVKKIRVKYWFKKDILELNNRFTPPISKKLNKFIISDDGAGENFAISKFFHSRLNGEYTSTKTVGTRSDIISTILLRALYLYGIVNDKSELSSIGKILVEFAKSVNSDISQEDFEHIILLVLLLDSKTLKLNEPSKEYTDVSNYYKKSMVDQQQQQQQQQQQQQQQQYSNQFSKQGLADDIVKKITLISRIFSFKKLNVSPINYQGPISRSLLNFRSHVEFINYNLINTLQLVLVDFIVRQEQNSIKTDYETKDDWYKLIDQLPFYKSLNNTLMGVISEIYFEMAIKQKQGQPQLTKEEIIKNCQNHLADHIFSVNIPSFNINVNGINSTSKTQLNNDFKQGVEWWKKFIILVDIINKIDKKLVDNSLYQEIKQADEFLKEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM03</accession>
    <name>A0A1D8PM03_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Calnexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ordered locus">CAALFM_C404090CA</name>
        <name evidence="20" type="ordered locus">orf19.12759</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717104.2">
        <property type="nucleotide sequence ID" value="XM_712011.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM03"/>
    <dbReference type="SMR" id="A0A1D8PM03"/>
    <dbReference type="FunCoup" id="A0A1D8PM03">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM03"/>
    <dbReference type="GeneID" id="3641225"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404090CA"/>
    <dbReference type="CGD" id="CAL0000187566">
        <property type="gene designation" value="orf19.12759"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04090C_A"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM03"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000048">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 18" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0000187566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AOW29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="581" mass="66731" checksum="AA10DBAA581D4F98" modified="2017-01-18" version="1">MKYALVLLLSLVNALKYVPFDKTQLDPSSVFEQFDYPSLNSSPWQVSTAKKFDEGRDEIVRYSGEWKIESSTSKYPGLEGDLGLVMKSRASHYAISYKLPHEVTNTNPNNNKTQDLVLQYEVKLQQGLTCGGAYIKLLDSSPSGYKFFNSETPYQIMFGPDVCGSENKIHFIIRKKLPNGAIEEKHLKHKPMARTNELTNLYTLIIKSNQDFEIRVNGQVAKAGNLYKNQKLFNPPFEPPKEIPDVDDKKPDDWDDRAYIPDPNVEKPEDYELKHEYPQIRDPNAVKPDEWDESAPRYIPDPDAVKPKDWNDAEKQWEPPLIVNPKCATGCGPWEAPLIPNHDYIGPWFPPDIKNPNYNGIWTPRLIPNPDYYQVKTPGKLDKPIGGIGFELWSIESDILFDNIYLGNSIAEAELIGNTTFKIKYELEADQRRENKPRVKNEPVAPPRNFEDIIRDDSISTFQQFLIFIKLFWLKQYVQLKDFYFELTLDPIGLIMANPLKTLLYAFLFLFSFTIFFGFASTIMFLLQGGEAFGSSSSITTTTTTDSNRKNVLTAEEIEMPSNHVQKIEILDEQIHVRQRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM75</accession>
    <name>RL30_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL30</name>
        <name type="ordered locus">orf19.3788.1</name>
        <name type="ORF">CAALFM_C404900WA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW29233.1"/>
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    <dbReference type="STRING" id="237561.A0A1D8PM75"/>
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    <dbReference type="GeneID" id="30515273"/>
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        <property type="gene designation" value="RPL30"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
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    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456509" description="Large ribosomal subunit protein eL30">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
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        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29233.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
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    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
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    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="106" mass="11505" checksum="070E3BC41906EEE3" modified="2017-01-18" version="1">MAPKSNKNQENINSKLALTIKSGKYTLGYKSVVKSLRTGKAKLVIIAANTPVLRKSELEYYAMLSKTPVYYFQGGNNELGTVCGKLFRVGTLSILDAGDSDILSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM97</accession>
    <name>A0A1D8PM97_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">RAD59</name>
        <name evidence="9" type="ordered locus">CAALFM_C405270CA</name>
        <name evidence="8" type="ordered locus">orf19.2630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_705029.1"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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    <dbReference type="GO" id="GO:0045002">
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        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
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        <property type="entry name" value="Rad52_fam"/>
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        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
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        <property type="entry name" value="Rad59"/>
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        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
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    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RAD59_fungi"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000201017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="215" mass="24972" checksum="E9DD9606D2754723" modified="2017-01-18" version="1">MTTSYLDTENDNDIDDNEEEEEEELANLPSTVKFFPNLSDLLDDEEYQDDDDDDGTNNNNTVINEWALRKFGTLQMKLEKMQHSRDTFQSFGSRDNLTNFSRNILYNLANEVFGFDGWSTTILDCNLTKRENKDENKYSALCVVKIRLILKDGTFREQSGQAESTNMPYKHMCYASARKKAVTDAIKNAIVGLRDLYLEYEQEQLMKQFAPEYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMB0</accession>
    <name>A0A1D8PMB0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">ABZ1</name>
        <name evidence="14" type="ordered locus">CAALFM_C405290WA</name>
        <name evidence="13" type="ordered locus">orf19.9352</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710092.2">
        <property type="nucleotide sequence ID" value="XM_705000.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMB0"/>
    <dbReference type="SMR" id="A0A1D8PMB0"/>
    <dbReference type="FunCoup" id="A0A1D8PMB0">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMB0"/>
    <dbReference type="GeneID" id="3648307"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405290WA"/>
    <dbReference type="CGD" id="CAL0000183785">
        <property type="gene designation" value="ABZ1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05290W_A"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMB0"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="324"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="536"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000183785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="822" mass="94376" checksum="A767880C5CE69DFF" modified="2017-01-18" version="1">MSGKKKKTQKKLKKIQTPIFPSINTNPRLTPIAPPLVSMILLIDSYDSFTNNLAHLLKESTGQEVITIHNDSFKPNEYETFYTQYLPLFQFIVIGPGPGHPAIESDIGIISWLIKKFQQQHQENDNNVVPILGICLGFQSLCYEFGNDVSRLQKVKHGQVYDIYPVSKSELFPDDESPFGSVRYHSLYVENTNDEIIPLAYCYEPSETDSQDKQKQKQTNKILMAMKHKKFPFYGVQYHPESICSSKGSDLIKNFNDIAQQYNEIYRPNVFKQNKVSNWLDNHAVHEDYLIKDGKFISNELHNIYFQKLQLDKEILPIDVCDYFYQQNSDDKCNFILLNSASIPGEWSIIGLPTIGESEIITHSVDDENHIYLSQFGSKTNEKQTLDGTDTVWNFIANKMQKAYISRETIKSKLNDYGKRELPFWGGYMGLISYEEGQHVIINKISNICQNGTTTTTTTTPDLKMVFITRFIAFDHVTKNWFIVAINDNDGTNWGQQIINDLHKVEKINLDNIPDSVNKLATKGDEDLIDFELPNRDIYKKQFNQCQEYLHSGDSYELCLTTQSKIHLPSYIQPWDIYKVLTLHKNPSPFSCFMDFDDCCLISSSPERFLSWKDDITSGNNNKIVQLRPIKGTVKNTDEITHEIATKILKTPKEMGENLMIVDLIRHDLYQFTDEVEVSQLMTVEEYKTVFQLVSVIQGKLYKEGYHGIDLLHRSLPPGSMTGAPKKRSVELLQDIESMQKNFVGGRRGIYSGVVGYWSITDDSDWSVIIRSVFHYSNDKENNPKTKLWRIGAGGAITVLSDVDDEWDEMMLKLTSALQAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMG4</accession>
    <name>A0A1D8PMG4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide diphosphatase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C405980CA</name>
        <name evidence="2" type="ordered locus">orf19.11887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711857.2">
        <property type="nucleotide sequence ID" value="XM_706764.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMG4"/>
    <dbReference type="SMR" id="A0A1D8PMG4"/>
    <dbReference type="FunCoup" id="A0A1D8PMG4">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMG4"/>
    <dbReference type="GeneID" id="3646516"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405980CA"/>
    <dbReference type="CGD" id="CAL0000198423">
        <property type="gene designation" value="orf19.11887"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05980C_A"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMG4"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
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        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000198423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="691" mass="78545" checksum="1AB7D7D6DC274858" modified="2017-01-18" version="1">MSINYNAQPHAVDVPVTDMDDPEDDIIFAEQASTQQNRTRSSFLDNLDFENNNARSESGGILNKFRSFFESRSRQDDDYEMVSRFDVDSTNESDDLDNQPPIDIRERRLQLLEKQVKNRTVVGSIFLLTVGILTFVLFFNKNSVTLLLNTGPSRKIYSNSTHEFHQTTILISLDGFHPHYINPLDTPTMHNIMKNDYGAPYMTPSFPSSTFPNHWTLITGLYPSEHGIVGNTFYDPELKKQFINTNPKVGGLDPDFWRGGEPIWKTAKRQNVRSAVHMWPGSEVPHIGPTDDFDRYNGSELLSSKVDRVMGWIDRESIETRPELILTYVPTIDQFGHKYGISGQNLTEALTYVDNFIDLMQQEIHKRNLDEIVNMIIVSDHGMAPTSNDRLLYLDDLVDLDKIEHIDGWPLFGLRPKGDINDFYTELSDNFDNLDSKVTSHYHIYKVEDIPPEFQFGGEITAHKYNYRLAPIWILPDVGYSITTHKQMEDNGFQYKPKGVHGYNNTHLLMRAIFLGTGPYFRNKNLKVEPFANTEVYNLICDTLDIVPAPNNGSLPQEIWSQKLPDEWKDDLTFPNLPFQVEHIVRTNATYDLLWRKGDEAKIDPAPVPTNKHPVESMKSEESTITSLETELLPKPSDFISSSTGTTMETSTTTKAHEGFGEIIGDIIGGIGDGFDAIGGVVHGFIDDIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PML6</accession>
    <name>A0A1D8PML6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein AFG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C406430CA</name>
        <name evidence="5" type="ordered locus">orf19.10409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715547.2">
        <property type="nucleotide sequence ID" value="XM_710454.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PML6"/>
    <dbReference type="FunCoup" id="A0A1D8PML6">
        <property type="interactions" value="826"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PML6"/>
    <dbReference type="GeneID" id="3642794"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406430CA"/>
    <dbReference type="CGD" id="CAL0000198513">
        <property type="gene designation" value="orf19.10409"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06430C_A"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PML6"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000198513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="62718" checksum="1CA71450AFC3141D" modified="2017-01-18" version="1">MRSIKYSLVKIPYQRSFFHTTSIRLQNTVNSNSDNAIPNNHITPLELYNQRVAENKLRDDPYQRKIITSLSKLHEKLTSYTPPKVITPSISDLTPKIGIAKIFSSFLGKTSIKNNSPSSLLVDEQTLLTVSNEVRGIYLYGDVGCGKTMLMDLFYDTIPENLPKKRLHFHQFMQNLHKRSHQLKMQHNNNNNNNNNNNNNTTKSGGGGRQHNDIDVIPLLASEIAQTSTILCFDEFQVTDVADAMLLRRLMMLLLSPQFGVILFATSNRAPDDLYLNGIQRVSFIPCIKLIKRQCHVIYLNSPTDYRKIPKPISSVYYFPKPGLKWDSKINKNNCIKHIESWYEYFNANNVKSDERLKNYKVEVWGRQLNVPICSPHYVAQFTFHELCGTPMAAGDYLALAQSFQSFIITDIPYLSIDVRDQVRRFITFLDAIYDNHGRIAVTSANSFKDLFVEPENIEKDNYYELHQKKKEQIETDPSSEEEEEEEEDEEDDELVIKHGFDKSIARKAKMFVNDEERFAFARALSRLSQMSTTEWIDQVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMQ4</accession>
    <name>A0A1D8PMQ4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">RPT5</name>
        <name evidence="14" type="ordered locus">CAALFM_C406870WA</name>
        <name evidence="13" type="ordered locus">orf19.10635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715432.2">
        <property type="nucleotide sequence ID" value="XM_710339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMQ4"/>
    <dbReference type="SMR" id="A0A1D8PMQ4"/>
    <dbReference type="FunCoup" id="A0A1D8PMQ4">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMQ4"/>
    <dbReference type="GeneID" id="3642911"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406870WA"/>
    <dbReference type="CGD" id="CAL0000178035">
        <property type="gene designation" value="RPT5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06870W_A"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMQ4"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="430" mass="47729" checksum="CBEA3DC2EC921B04" modified="2017-01-18" version="1">MVTLEDLENNQQQEENVIDQEILNSSTSDIINRTKLLDNDIKVMRSESQRLNHEKTVMLERIKDNQEKINNNKQLPYLVGNVVELLNLDADKEASEQGANIDIDAARAGKSAVIKTSTRQTIFLPMIGLVDPSKLKPNDLIGVNKDSYLVLDTLPSEYDSRVKAMEVDEKPTEDYSDIGGLDKQIEELIEAVVLPMKQADKFKNLGIKPPKGALMYGPPGTGKTLLARACAAQSGATFLKLAAPQLVQMFIGDGAKLVRDAFALAKEKAPTIIFIDELDAIGTKRFDSDKSGDREVQRTMLELLNQLDGFGSDDRVKVLAATNRVDTLDPALLRSGRLDRKIEFPLPSEEARESVLKIHARKLHCDNNSVNWRELARSTDEFNGAQLKAVTVEAGMIALRNGKSIIKHEDFVEAISEVQARKSKSVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMT0</accession>
    <name>A0A1D8PMT0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C407200CA</name>
        <name evidence="7" type="ordered locus">orf19.10595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_710300.2"/>
    </dbReference>
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    </dbReference>
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        <property type="gene designation" value="orf19.10595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07200C_A"/>
    <dbReference type="eggNOG" id="KOG3662">
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    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="entry name" value="Cell division cycle-related protein"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="48"/>
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        <location>
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        </location>
    </feature>
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            <end position="304"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000184667"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="400" mass="47361" checksum="EA7671A1940135E6" modified="2017-01-18" version="1">MNTLRRRRIPKPIPRIFEDDEYKQYTRPHNWRLLSLVGICWVLLIHYFERTCPQNTLSACQWKNWEQWNSPDSAHRIVLIADPQIVDDYSYPKQFKIINYFTKKLADNYLHRNYEMIHSVLAPDTTIFLGDLFDGGRYWDDKQWIDEYKRFTKIFPKKINRRDIRSVPGNHDIGFQTIRHKVVKRFAEYYGELNDYIELGNHTLVLLDSISLSHPDKLIRKEPDNFLDQLNNRISSTFPRILLTHVPLFRNPATQTCGSHREKRKPFPLQRGDQYQTVIEYEISRRILNTIKPTLIFAGDDHDYCDITQEYDGGAAREITVKSAAMTGGIKHPAVQLLSLNTNEPTRTYETEMCYMPNAYHGLYAYITFLLLTSFFIDRSIVFLNLVWPLFILNVYYMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMU3</accession>
    <name>A0A1D8PMU3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C500160WA</name>
        <name evidence="2" type="ordered locus">orf19.5681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705418.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PMU3"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C500160WA"/>
    <dbReference type="CGD" id="CAL0000188898">
        <property type="gene designation" value="orf19.5681"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00160W_A"/>
    <dbReference type="eggNOG" id="ENOG502SAH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMU3"/>
    <dbReference type="OMA" id="VEHNSGV"/>
    <dbReference type="OrthoDB" id="4078936at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000188898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="244" mass="28057" checksum="89C9F238EA803FAD" modified="2017-01-18" version="1">MLSTTIYRRSFSVLSRSRAKRSFTPSDSSVESDEIVSENNPWSPTLEDDPVYVQERNKFRKTKLPEQYRLAYSPLYEAPASKYVSMLKRLTLSVGVLGVYGAKLFYESSQFDDLYAYATLAGTFTPLAVVQYKTKDYVTRIFRLYDKTKPQTLENLVGDEKLILEKLNFTGGSTYNELLTITDNKDLKLSPPPKTYLPYSTWRESSGSTTRDFYVMDNIGGIRMDRIWGLIEKNSQINNGRSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMX3</accession>
    <name>A0A1D8PMX3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C500320WA</name>
        <name evidence="5" type="ordered locus">orf19.961.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330949.1">
        <property type="nucleotide sequence ID" value="XM_019475404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMX3"/>
    <dbReference type="SMR" id="A0A1D8PMX3"/>
    <dbReference type="FunCoup" id="A0A1D8PMX3">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMX3"/>
    <dbReference type="GeneID" id="30515291"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500320WA"/>
    <dbReference type="CGD" id="CAL0000186624">
        <property type="gene designation" value="orf19.961.2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00320W_A"/>
    <dbReference type="eggNOG" id="KOG4612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMX3"/>
    <dbReference type="OMA" id="WCKRIST"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000186624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="97" mass="11075" checksum="FBE762DDD188E83B" modified="2017-01-18" version="1">MFSNILRQSSRGLINFTSVSSRPLGVPAFGMNPLITSSPLQSVVGLMQQRFKSRGNTYQPSTRKRKRKLGFLARLRSIGGRKILERRRAKGRWFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN69</accession>
    <name>A0A1D8PN69_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">PRC2</name>
        <name evidence="9" type="ordered locus">CAALFM_C501450WA</name>
        <name evidence="8" type="ordered locus">orf19.11612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711339.1">
        <property type="nucleotide sequence ID" value="XM_706247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN69"/>
    <dbReference type="SMR" id="A0A1D8PN69"/>
    <dbReference type="STRING" id="237561.A0A1D8PN69"/>
    <dbReference type="GeneID" id="3647044"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501450WA"/>
    <dbReference type="CGD" id="CAL0000177583">
        <property type="gene designation" value="PRC2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01450W_A"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN69"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009026870" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000177583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="498" mass="56302" checksum="0940DA0E22552959" modified="2017-01-18" version="1">MKALLLLYTVITVVLALPSQTPFSLSPLQQLKDELAGKVSQTQILDMERIWINYQRQNGLETILKEFNQFKSQFQYSLASQDKSESTYSIEVSKASPELLGFDTVKQYTGYFNVNDKDKNYFFWFFESRNDPKNDPLVIWLNGGPGCSSLCGLALELGPSIINATLQPEYNPHAWNSNASVLFLDQPANVGFSYGGNIPITSDQASQDFVEFIKLFYERFPEYVDLDLHISGESYAGHYVPSFANAVHKADIPLNSILIGNGVTDPVVQLGEKSNMGCGQGGIGKIYTDKECTEYPEKYEKFVPYGELCYKNPNALTCFIAALASPKTPDTGDLNPYDSRVKCGNNSLCYDQIDYLNDYFNLQSVQEALGVEKTYTMCSSNVGSRFVSDFMRPYHTYVADLLDDGIPVLIYVGDKDLVCDWLGNLAWVNKLNYTGHDQFEKTEFKPWYTADGKLAGEVKNHDHFTYLRIYESGHMVPMDQPENSLDMVNRWVRGDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNM5</accession>
    <name>A0A1D8PNM5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C503300CA</name>
        <name evidence="2" type="ordered locus">orf19.10173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712032.2">
        <property type="nucleotide sequence ID" value="XM_706939.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNM5"/>
    <dbReference type="GeneID" id="3646357"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503300CA"/>
    <dbReference type="CGD" id="CAL0000201098">
        <property type="gene designation" value="orf19.10173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03300C_A"/>
    <dbReference type="eggNOG" id="ENOG502SNTU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNM5"/>
    <dbReference type="OrthoDB" id="4076777at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
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        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="765" mass="90169" checksum="9A6708E6A70A4DBB" modified="2017-01-18" version="1">MYGLRSSVKNLLKHRYYYLGGGGFSYRINQRSFHQNRILRKDEKTKELLKNLGLNLQKGTINRSNKTKDNNNNKSGSSVKNEKTNDNGDENEGNEGNVTRINENDNGDDDKTDNQLVSTVTDIPPDPNEIETKSTKSNDNNNNNNNSNTIKTNSHGNNNSTASNGINNKKISSEPNKNKKSMKPTKPGKLGKPGKLNKIKPSNVDENIVHEQLENAFVTVALMTNKEFLEQIALDGRNFPFKHFKSDYLIDRQEILRQIPDMINIFNKQDMKKIEQIYQNLSKLDQDKSMHLQFLKQSFIDYKNDLLYLDQFLRGINSKFKQYRRGEVRYFFVYPTVFEHVHDKILHQYNVVGFDRSLFGMPLDKQLDKLVLPREFIQDLPQFDNIIELNKIDASLGFKLVEEQQFGKLIDSLWDPRMVKPLKELQKEYKERLNEQKKDKNQQLEKQLQPPLKSKDDTINGKQPDKKFIVIKKGGYRQIKLKESSLQYSPVIRRIEEEIELMINDLNKQIKTTLESDNIKVLIPNENENENDKNDKETITTFTSPTGSQPTSRIKTNFYEIVFKKKIYQGYLVSVERLISKNFNILPNYALLYHKINYPPLIKRKLLNHIFKIFLININEKFNYLQKIKYLTQRQQIEFHKKLIKQIKYIIRFKLLRYFDNNTLNQTTNSLKLNNLNVFHHEEEEEEERYDNNFDKSKQRQRKTFGGAHAVIFNPYTDNCFKRIYWISSPYPSSIIKRQNMNLKRKFTKIKFKTIDERYITTTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPK6</accession>
    <name>A0A1D8PPK6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin-protein transferase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">CDC20</name>
        <name evidence="11" type="ordered locus">CAALFM_C601150WA</name>
        <name evidence="10" type="ordered locus">orf19.7769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714328.2">
        <property type="nucleotide sequence ID" value="XM_709235.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPK6"/>
    <dbReference type="SMR" id="A0A1D8PPK6"/>
    <dbReference type="FunCoup" id="A0A1D8PPK6">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPK6"/>
    <dbReference type="GeneID" id="3644057"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601150WA"/>
    <dbReference type="CGD" id="CAL0000185508">
        <property type="gene designation" value="CDC20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01150W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPK6"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990333">
        <property type="term" value="C:mitotic checkpoint complex, CDC20-MAD2 subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040020">
        <property type="term" value="P:regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="267"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000185508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="634" mass="68875" checksum="BC8790E3474D0D22" modified="2017-01-18" version="1">MSPNISNRTVHLPNDTPLKQQSLKRPSISSSSTSGTGTGSGAAVEVAADSTSTTNLKPISKPISKFQRPQLPPSLRPPINSRSKTAVLPSLSKSTSSLATTHSSTQSLSNPFILRRANSLISQGGSSSLSDLHQQQQSSTTSSDRFIPSRYNSVTGKLDTTNEVPLPSAAPEIHIKAQTSKIYQHHVAEACGLEMNSRILLYQPLPPERKKPVNLVRQLSNQSSSGSSSIPNSQLFRTSFLTKSGTLTPSAAAARANKIPNAPERVLDAPGLIDDFYLNLLAWSSTNLLAIGLEDAVYVWNASTGSVGLLCELADKTLVTSLRWSQDGSYISIGKDDGLIEIWDIESNTKLRTLNCDNHLTRIASQSWNQHVLTSGSRMGHIYFSDVRVANHLVNKNQEAHSAEVCGIEYRPVGNGTSSTTSINDSLQFATGGNDNLVCIWDARNVTTPVFSKSNHKAAVKALSWCPYQSSLLATGGGSTDKTINFWNTTTGAKVNTIETGSQISSLNWGYAHGTGLEIVATHGFPSNSISLFNYPTLQKTGEIINAHDTRILNGCLSPDNLTLATVAGDENLKFWSLFDLYKNNKRDYSHLRHGQDRDNQYNDYDDSDVNGLNNDDKDGGHDSKRIKKMMNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ43</accession>
    <name>A0A1D8PQ43_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Ribonuclease H</fullName>
            <shortName evidence="11">RNase H</shortName>
            <ecNumber evidence="4 11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C603260WA</name>
        <name evidence="14" type="ordered locus">orf19.13057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 11"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719174.2">
        <property type="nucleotide sequence ID" value="XM_714081.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ43"/>
    <dbReference type="SMR" id="A0A1D8PQ43"/>
    <dbReference type="FunCoup" id="A0A1D8PQ43">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ43"/>
    <dbReference type="GeneID" id="3639183"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603260WA"/>
    <dbReference type="CGD" id="CAL0000187941">
        <property type="gene designation" value="orf19.13057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03260W_A"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ43"/>
    <dbReference type="OMA" id="ELWYGLY"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF30">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="13">
        <location>
            <begin position="111"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000187941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW30256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="285" mass="29911" checksum="7DA58868B906CF7F" modified="2017-01-18" version="1">MPYYAVAKGSKTGVYSNWGDCKEQVHGYSGASYKKFSTAAEANAFVQSGGKSGSSSSYSSGGRSSGGISGSSRSSGGYSGGYSGGYSGGYSGGYSGGSSKRSSSSSTSSSSTTTNRVYVDGASRGNGQTSKAPSGYGVYYGPNDSRNVAVPLDRVDKNTSYKPTNQRAELHGVKHALKNIHNDLQSGKATGKTEIHSDSKYAIQSVNEWSSNWAKNGWKNSKGETVANKDLIQETVALKNSINKTYQDKNWGNLEFVHVKGHAGDPGNEAADRLANQGADQYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQY7</accession>
    <name>A0A1D8PQY7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">MSK1</name>
        <name evidence="8" type="ordered locus">CAALFM_C701870WA</name>
        <name evidence="7" type="ordered locus">orf19.13886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721371.2">
        <property type="nucleotide sequence ID" value="XM_716278.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQY7"/>
    <dbReference type="SMR" id="A0A1D8PQY7"/>
    <dbReference type="FunCoup" id="A0A1D8PQY7">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQY7"/>
    <dbReference type="GeneID" id="3637032"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701870WA"/>
    <dbReference type="CGD" id="CAL0000184486">
        <property type="gene designation" value="MSK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01870W_A"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQY7"/>
    <dbReference type="OMA" id="MQERHVD"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="535" mass="60769" checksum="AA28B34F1B6DF06A" modified="2017-01-18" version="1">MLSHRLIPRVIPRVGNFIRPFLVSHYSTTLDADNLTYENRKGIITNDGKNHVDSKYYPSLSAVRQRLAGSEKLRVKEFCKNFKDVVKFSDIDNNRSCEIYLLEGRITSIRKSGKAMYFIDIVQDDCSVQIMATNKLMGMDPTAFNDCHSFFKIGDYIAVRGYASRTKTGELTLKLNKQIEMLTPVLSKMPNRLEDRGLINNNRVLNYLVNRDSKDAIIVKSKVIQAIRNFLLDRDFLEVQTPILSGQGTGANATPFVTKFKGEPVHLRVAPELWLKKLVIGGFDKVFEIGSNFRNEGIDMTHNPEFATCEFYQAYTSLDELMKMTEDMFGYVFDKLGVTDKFPTGNFPKYEFLPTIEQKTGVSITDLTLDGLVNYHKRLDLAVPPNPNPVKLLNNLSEIYLESICSEHPNTPVFIYNQPEIMSPLAKSITDAAGNRISSRFELFINAREMANAYEEENDPCKQLEKFKLQQKMKADYNDQEMLIPDHNYVWAMEYGLPPTGGWGCGIDRLAMLIAGANRIEDVLTFGTLSSVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR55</accession>
    <name>A0A1D8PR55_CANAL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">CAALFM_C702610CA</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C702610CA"/>
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    </dbReference>
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            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="316" mass="36608" checksum="3415EE3EA6C1848F" modified="2017-01-18" version="1" fragment="single">DDNEGKVMESVDQANAISKVDEHIKARFNMLFIKFNDLPKLAVGNQKSVDKWNEEFKYFHVAYPDVLEFLLDYNPKDKFKVKKVEGIYFTGWCLQMCLQSIFDRFRLIMISKLPKHLQKEANLIKAAYDAVTKSKDYTITSKILSKFVNVEHELVVCYNLPYLSQVEEKLEEILYNTSNVVDEYVRSLPNLIGQVLYFNHVKKSEALSLFLNIHTSYYSKWIQADNDTSVLPSCSTIAEEMCDHPDYARLVDIPSNKYELNLIVSLPAPEKPKGKPEENSSEQSQKKNSKSRKRNKKHPKSDKDKGEKEKEKTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS24</accession>
    <name>A0A1D8PS24_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="8" type="ordered locus">CAALFM_CR01720WA</name>
        <name evidence="7" type="ordered locus">orf19.10097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718232.2">
        <property type="nucleotide sequence ID" value="XM_713139.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS24"/>
    <dbReference type="SMR" id="A0A1D8PS24"/>
    <dbReference type="FunCoup" id="A0A1D8PS24">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS24"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR01720WA"/>
    <dbReference type="CGD" id="CAL0000196366">
        <property type="gene designation" value="orf19.10097"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01720W_A"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS24"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="96"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="354"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="682"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000196366"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1032" mass="120269" checksum="BBF38CE4212F9A61" modified="2017-01-18" version="1">MYDHLPRILKWSICLAIVFWYINQNSILFVLSIISGIILLCLVMVYYTTKVQISRSPPIQRRHRRFNFTLSKHWKQEITQLQNEQIEVKRPIFSESFLISESLQRFIDLIIQEFISPWYTQITQSAQVQTDISLEFKEVIRNLQNRAKSIDFAQLLVSNILPLLQEHFEDYLRAEDIIKSQGKFSKFDSNEYHIAVASQFRRGKLHPAVTTSLIVNEETNFKEKQYLRKKMKNVLELALSENEKFNDVGISLVTEILACTVLCNVINLLTESDFYNLIIVKLIGDNLRRRDQVKQLRAALEEHTQKCSKEIDDNKVQVPDMASALLTPDSNLQNQLKLKISERKQQREKQKSLNLKDILTDKNNFQVFKEFMESEGRSKLVEFWKAVEMIKAPLEGEENDDETDPLALSLEFGNNDDVYNIYTKFIKTNEIPQPDTHIVEVLSNSGNSANVRTYQEARTYLFKMQRDCFDQMQSHDLPVFVNSEMYLRLVSPKESSEVNPDVINAVENAFTLIMNKPESLDTRFDGSDEFNSDQLLTTLQLKSDLFGESSTNLSDGNHSNRNSRLFDDFLSDDDQSDSDGDSLYSDKHSQSMNNSNSEVQFAAPGNLNLAEEIPKLSDEVDNLQKQITILEPLLRKAELTNNLSELKVLQKSKIGLIREINIKELQKQQFIVQENDNSLFGKSRVCIQSYINDNEKNGREFTLYIIEVQKFSNENPNIVKAGWVVARRFSQFYGLHEYLKSKYHRVSYLKFPKKSISVLKFQQKQVAEIRMKQLEDYLQELIKIQEVCSDRAFRSFLSSENFNLKKNQRFEETRAKNYSDTNFQSLFGSKWYRGISNFMTTTKNDENHKDSTYIDTHIMENLRDMESELKQFDEAASARTPFVKPICDLLISVFKLHNSRSWLRGRALVVILQQMLGTTVEKKVYDVVEGRLKTEENVLDLIMMLTNILFPNGKFKDPPVIRSLYQQSNTRQEAKVLLEIFIFETCSTIFGRHNSIFASTEIFSMIQNEYLNRNLVFEIFDEILEHMFVEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSF5</accession>
    <name>A0A1D8PSF5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kti12p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">KTI12</name>
        <name evidence="6" type="ordered locus">CAALFM_CR03370CA</name>
        <name evidence="5" type="ordered locus">orf19.9921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713218.2">
        <property type="nucleotide sequence ID" value="XM_708125.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSF5"/>
    <dbReference type="SMR" id="A0A1D8PSF5"/>
    <dbReference type="FunCoup" id="A0A1D8PSF5">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSF5"/>
    <dbReference type="GeneID" id="3645140"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03370CA"/>
    <dbReference type="CGD" id="CAL0000192073">
        <property type="gene designation" value="KTI12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03370C_A"/>
    <dbReference type="eggNOG" id="KOG3062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000192073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="288" mass="32724" checksum="EF060A5E54672DAB" modified="2017-01-18" version="1">MPLIIFTGYPCSGKTKWAKLLQKELEIKIQTAKENSEPGQNYTVTYHSDETLGINHETYQDSNKEKLARGSQISAVKRDISRTNIVILDALSYIKGFRYQLFCEAKGNVTPHCIVHVIAPIEKCIQWNDTKESGNKWDPVLIKQLQMRYEEPNSDTRWDSPLFTILSEDPQEKIPIEDIWNALVLKKAAPPNAATLVKPTSGNSFLQELDKKTQEVVTKILQQQQITPGDVVIDKNLVVAIPTGTASTAQLQRIRRSYIGLNRMRSIEVDRIVPLFVEYLNRSLNSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT82</accession>
    <name>A0A1D8PT82_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gst3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">GST3</name>
        <name evidence="5" type="ordered locus">CAALFM_CR06460WA</name>
        <name evidence="4" type="ordered locus">orf19.8339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713080.2">
        <property type="nucleotide sequence ID" value="XM_707987.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT82"/>
    <dbReference type="SMR" id="A0A1D8PT82"/>
    <dbReference type="STRING" id="237561.A0A1D8PT82"/>
    <dbReference type="GeneID" id="3645278"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06460WA"/>
    <dbReference type="CGD" id="CAL0000178761">
        <property type="gene designation" value="GST3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06460W_A"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT82"/>
    <dbReference type="OMA" id="TLAQSEW"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="90"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000178761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="215" mass="24961" checksum="BD19CFD325DACA69" modified="2017-01-18" version="1">MTLTLYTAPTGNGRKPLVFLKLLSIPHELHLFSWPTKDIKQDWYLKLNPQGLVPTLVDGELILPESNAILQYLAETYDKQGKFSYNLQTDPLEYWQQQKWLFYQATQFAGTLFRFNTYIGIKADDGKVWDNILQSFADAYKVIDETLAQSEWFVGDKFTIVDIAFGVGNHRRIEVVARVGLDKHFQDYDTKYPHVAQWYKKFLEVEGVKEALALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT95</accession>
    <name>A0A1D8PT95_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HRD1</name>
        <name evidence="20" type="ordered locus">CAALFM_CR06470WA</name>
        <name evidence="19" type="ordered locus">orf19.8338</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713079.2">
        <property type="nucleotide sequence ID" value="XM_707986.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT95"/>
    <dbReference type="FunCoup" id="A0A1D8PT95">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PT95"/>
    <dbReference type="GeneID" id="3645277"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06470WA"/>
    <dbReference type="CGD" id="CAL0000177443">
        <property type="gene designation" value="HRD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06470W_A"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT95"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000674">
        <property type="entry name" value="HRD1p Ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="389"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="450"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="520"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000177443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW31346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="633" mass="71401" checksum="8DF3CB6945EE4E8E" modified="2017-01-18" version="1">MLINKTQQYIIGYSSISIALLSWSIYDSLRKSFNFVMFLVEFTDGIKLGIIVNFIIFLFLIIDKSLQILLFGSLRMIEVEHLFEKLPIFVINLLLNLATGDNNIIMNVFLMGLSMSFKVFHVIMFDRLDYVNLIIVNKINDEDIYLNQVIYHFGTSINFWLNIFFIFADFSLAKFLVYDVFQGINSVTCLLFGFQFAVQGVQALTYFSKLLLGIYEIAFYRIRKNEHHTSLRGWQESTTTSANLEETERTTNNNDNESGQVEVEVEANIDEDVDVDADADADVDVEEEIVNDEDDDIELIWDNKPYYTKGIDIASAVLTSISYLSFVYLLTIHSGLSLPLSMLQGTYSSMRRAWVETNQLLAFIESSKRLDTQLANASAEDLSQSDSLCIICREDMHSVEDYQRIFKKPQSPRRSPKKLKCGHILHLGCLKEWLERSDSCPLCRRKVFSNDGATNATNNNNNNNGENNQNNGNVPPPQPGDVPVPPPAPTATATATAAAVNAELQREVREINDLLQNAENTIAPQEQPINTAAEPIEGPSRTIPLPSSSSTLPIPQSNDLSQSITLPKNALLPPGWLVIPLKKPEQENSDIDYKVNISSYHQADLKINNKKPSTRDIITYAIPKEESIGEYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTD0</accession>
    <name>A0A1D8PTD0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="17">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">POL2</name>
        <name evidence="21" type="ordered locus">CAALFM_CR07000CA</name>
        <name evidence="20" type="ordered locus">orf19.9901</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="17"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712655.2">
        <property type="nucleotide sequence ID" value="XM_707562.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTD0"/>
    <dbReference type="SMR" id="A0A1D8PTD0"/>
    <dbReference type="FunCoup" id="A0A1D8PTD0">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTD0"/>
    <dbReference type="GeneID" id="3645733"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07000CA"/>
    <dbReference type="CGD" id="CAL0000195005">
        <property type="gene designation" value="POL2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07000C_A"/>
    <dbReference type="eggNOG" id="KOG1798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTD0"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035822">
        <property type="term" value="P:gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="19">
        <location>
            <begin position="1518"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0000195005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AOW31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2211" mass="255879" checksum="6DA267FE7BBF0CA7" modified="2017-01-18" version="1">MSSRPNAFKGSNSARFVKNQMTTNYRNTNDYRQQNNRNRQQQQPEDPYVANNPMLNDSIQKKELVERIDHIDSIMGFDRLEHGENDGNKPRKGWLINMHATTIPTDDYLAGYSGVDYYFLDEEGGSFKATLQFDPYFFVDVLPGDHESEVEEWMRKYLETANVKSYSRVIKEDLKLPNHLLGLQKTLIKLSFHNIQDLLAARRLLSPIIKDNQLKKESRNMYTFKEIETIMDPSVYIDDIREYDVPYHVRVSIDRNVRVGKWYDVYAKHSKVDFVEDKEKIAFADPVVLAFDIETTKAPLKFPDAKIDQIMMISYMIDGEGFLITNREIISEDIDDFEYTPKPEYPGLFTIFNEPDEKHVLKRFFEHIRDVKPTVIATFNGDFFDWPFVENRTRFHDMDMFEEIGFAKDNEGEYKSKYCVHMDCFRWVKRDSYLPQGSQGLKAVTTAKLGYNPTELDPELMTPYAYDKPQLLSEYSVSDAVATYYLYYKYVHPFIFSLCTIIPLNPDEVLRKGTGTLCEMLLSVQAYEGNILLPNKHSDPIERFYEGHLLESETYVGGHVESLEAGVFRSDIPTHFKIDPTAIDELLGNLHNSIKFCIEVENGKKMEDVENFDEIYTQIESSLLELKNNPSRQEKPLIYHVDVASMYPNIMTSNRLQPDSMKSEEDCAACDFNRPGKNCDRRLPWAWRGEYYPAEMNEYNMIKRTLQNETFPGARPWLPPRTFDELSYAEQAAKIKKRISDYSRKVYHRVKSSKVVTREAIICQRENPFYVDTVRSFRDRRYEFKGLAKVWKGKVGKIASNDTIARDEAKKMVVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGVTCLTGATIIQMARALVERIGRPLELDTDGIWCILPKSFPENFNLKCKDGKKIFLEYPCSMLNYLVHERFTNHQYQDLVDPETFKYKTRSDNSIFFEVDGPYKAMILPTSKEEGKGLKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKLFLEGDTLDTCYQAVATVANNWLDVLDTKGGMLEDEDLIELICENRSMSKSLADYGDQKSTSITTAKRLGEFLGEEMVKDAGLATKYIISAKPIGSPVTERAIPVSIFSSDKKEIFLKKWLKDPSLNKFSPRDVIDWNYYYERLASVVQKIITIPAALQDVKNPVPRVPHPDWLQKKVKNSEDIMQQKSISNFFKKTTKEDIKLKDIEDFGEVDASVPKGKVVKVTSRKRKSGKANMVEDAEEDEKNQAILNGPCPSMTEDYQGFLQYQKAKWKVQQAGRERRRRLFGANSESSQRSTVGGMFRKRAENIAGTNWEILEYKLDPTKPGDLKVYVRAGDKVHTFNFHVPKKVYASFKTKLSQRKSIPGCEIEESNAILPNGHDGTNLYKLTMAQSVFQEQMSDVDSLLQDSNIMGLYESNIDPVSRAIIDLGNTVKFDDTRVGALGKGLKTGFNTRELIKASSEAYLRKFDMDIVYLLHIVTNSYEFFALFNTWENDCQMFVLKPSANAQELPNNIHKIYREIFESKREKLDKVSNVVNYPAEMSFDVKYYHESAKLFKKLNQVIGKIHESRSNKAFLAIQSPYSSRILNVLNTTDDFPTIKMNISELSLPAVGWQSLISKRVINHYFVLGSWIKNLVAFAKYANVPLCNLQIENIGFLVDIEYARRLSENNIVLWWSPNPLPDLGGFEMDRMVDFDSLAFPTINNPEIYETACLEVEIGTLTINTILTSALINEAEGTDLADENMHFDNNNGASTFAEDSFSSPALSILRSMVKDWWDDALSNNINADSIMNTLVTWVQRNDSMLYDPSLHYHVHNLTSKALLQLISEFKRMGAQVIFANRNKMLIQTSKISVENSYAYGQYILKAARSKPLFNFLDLRIVKYWDILIWMDEFNYGGRSCTEIVNEEMQNLVPENHWHLQKFLPIIFQNEFEDWLVIFLDALTKYKNENLLGKGAQANTPRVTQIVHILKGQKKLQAQEVEEEDDDHGVIETFKKPILRRMEKLYRRQLEAILNPEFKQEYEFPTLAGSYLHMKNPALELVKFLCHVFALSEKRSKEVRILKKELLLIFDVRDFSKDATFRDPCTSLKLPHVICDYCNHIRDIDLCREEEINIWNCLNCHKAYNKIALEEEIINQFNKLFVKFYGQDLKCNKCNQIRQNNMDLHCKCSGNWIETVDYHTIEKQFQTFVNVAKFYNLQLLNGLVEEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU26</accession>
    <name>A0A1D8PU26_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_CR09810WA</name>
        <name evidence="3" type="ordered locus">orf19.7553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719315.1">
        <property type="nucleotide sequence ID" value="XM_714222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU26"/>
    <dbReference type="SMR" id="A0A1D8PU26"/>
    <dbReference type="GeneID" id="3638985"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09810WA"/>
    <dbReference type="CGD" id="CAL0000184752">
        <property type="gene designation" value="orf19.7553"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09810W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PU26"/>
    <dbReference type="OrthoDB" id="4020357at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000184752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW31638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="237" mass="28524" checksum="91CE05FB1125BEDA" modified="2017-01-18" version="1">MAMSELLKRYQQSRKEATDTSKSRLPSIKTDPIYPSYSNLDGIRNQSRYQSRTYGGISKPTKKTSLLNTSPIYKKYESLNLPSSSQIYKREIEKKPRFTINDKNEESIFSKITKYFQHGEENEEKPERVDIADKYLNDDRDEVDELILRVKESEKKYERERLKKLEEDNKRIQNELDDIKLENRKLKDQIERMEIRNRKELNQLDKKLFELENKLIMETQTTRRSNNYRRSTYSKDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2025-02-05" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>O94091</accession>
    <accession>A0A1D8PER6</accession>
    <accession>Q9P8W6</accession>
    <name>LIP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase 1</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LIP1</name>
        <name type="ordered locus">CAALFM_C109580CA</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Arch. Microbiol." volume="174" first="362" last="374">
            <title>Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members.</title>
            <authorList>
                <person name="Hube B."/>
                <person name="Stehr F."/>
                <person name="Bossenz M."/>
                <person name="Mazur A."/>
                <person name="Kretschmar M."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="11131027"/>
            <dbReference type="DOI" id="10.1007/s002030000218"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1997" name="Microbiology" volume="143" first="331" last="340">
            <title>Cloning and characterization of a gene (LIP1) which encodes a lipase from the pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Fu Y."/>
                <person name="Ibrahim A.S."/>
                <person name="Fonzi W."/>
                <person name="Zhou X."/>
                <person name="Ramos C.F."/>
                <person name="Ghannoum M.A."/>
            </authorList>
            <dbReference type="PubMed" id="9043110"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-468</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC 36082</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="4" first="401" last="408">
            <title>Expression analysis of the Candida albicans lipase gene family during experimental infections and in patient samples.</title>
            <authorList>
                <person name="Stehr F."/>
                <person name="Felk A."/>
                <person name="Gacser A."/>
                <person name="Kretschmar M."/>
                <person name="Maehnss B."/>
                <person name="Neuber K."/>
                <person name="Hube B."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="14734020"/>
            <dbReference type="DOI" id="10.1016/s1567-1356(03)00205-8"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="FEMS Microbiol. Lett." volume="244" first="359" last="365">
            <title>Differential Candida albicans lipase gene expression during alimentary tract colonization and infection.</title>
            <authorList>
                <person name="Schofield D.A."/>
                <person name="Westwater C."/>
                <person name="Warner T."/>
                <person name="Balish E."/>
            </authorList>
            <dbReference type="PubMed" id="15766791"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2005.02.015"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 6 9">Secreted lipase that is able to hydrolyze both the neutral triacylglycerols and the monopalmitate ester Tween 40, allowing the use of hydrolyzed products as carbon sources (PubMed:11131027, PubMed:9043110). Has broad lipolytic activity, which may be important for colonization and subsequent infection, therefore contributing to the persistence and virulence in human tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5 6">Expression is induced when cells are grown on media containing Tween 80, other Tweens or triglycerides as the sole carbon source, but not in Sabouraud Dextrose Broth or yeast/peptone/dextrose media (PubMed:9043110). Expression is up-regulated during the yeast-to-hyphal transition (PubMed:11131027). Expression is inhibited in the presence of carbohydrates (PubMed:9043110). During host infection, expressed in gastric tissues, but not in infected oral tissues (PubMed:15766791). Expression is induced during biofilm formation (PubMed:21414038).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="AF188894">
        <property type="protein sequence ID" value="AAF35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U34807">
        <property type="protein sequence ID" value="AAC99990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723507.2">
        <property type="nucleotide sequence ID" value="XM_718414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O94091"/>
    <dbReference type="SMR" id="O94091"/>
    <dbReference type="STRING" id="237561.O94091"/>
    <dbReference type="ESTHER" id="canal-LIP1">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="O94091">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_09580C_A-T">
        <property type="protein sequence ID" value="C1_09580C_A-T-p1"/>
        <property type="gene ID" value="C1_09580C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634888"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109580CA"/>
    <dbReference type="CGD" id="CAL0000177069">
        <property type="gene designation" value="LIP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09580C_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00472"/>
    <dbReference type="eggNOG" id="ENOG502S2P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PER6"/>
    <dbReference type="OMA" id="EGCTIQN"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="PhylomeDB" id="O94091"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000017820" description="Lipase 1">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="112"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15766791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21414038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="9043110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="9043110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <sequence length="468" mass="50811" checksum="4FF3C05A948B14DA" modified="2003-11-21" version="2" precursor="true">MRGIAVFLAFISLIFASPLTVKSPLVDDFYTAPDGYESAKLGEILKLRKTPSKLSSMFFEIDIKNSWQLLVRSEDSFGNATAIVTTVIEPYNADPSKVLSYQTFEDSANIECSPSYGMQYGAPWSTVATQIDMALMVPMLKQGYYVVSPDYEGPKSTFTVGRQSGKATLDSIRAILKSNKFTGIKSDAKVAMWGYSGGSLASGWAAALQPKYAPELKKNLIGAALGGFVTNITATAEATDGTLFAGLVPNALSGLANEYPEFKEILYQKVSKAATDNLRQGTEHCIGGAILYFAEDQYFTGDDRAFPGGYGLLKEEVVNKTISENNLMQMDKDYLPDIPIFVYHGALDSIVPISNVHVTYKNWCDWGINSFEFSEDLLNGHITETIVGAPAAITWLEARFDGEPVVKGCKKTSRITNFSYPNISDSTSSIFEGILNSVTGSELGPGVTSDNITLDGLTGFLGNFIDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PV3</accession>
    <name>Q59PV3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD-repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">SWD2</name>
        <name evidence="9" type="ordered locus">CAALFM_C107550WA</name>
        <name evidence="8" type="ordered locus">orf19.10306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711732.1">
        <property type="nucleotide sequence ID" value="XM_706640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PV3"/>
    <dbReference type="SMR" id="Q59PV3"/>
    <dbReference type="FunCoup" id="Q59PV3">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PV3"/>
    <dbReference type="GeneID" id="3646677"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107550WA"/>
    <dbReference type="CGD" id="CAL0000198527">
        <property type="gene designation" value="SWD2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07550W_A"/>
    <dbReference type="eggNOG" id="KOG1446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044117_3_0_1"/>
    <dbReference type="InParanoid" id="Q59PV3"/>
    <dbReference type="OMA" id="KICVLNG"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000198527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="364" mass="39802" checksum="19D53D8E4FF7F30C" modified="2005-04-26" version="1">MNSSRSANNSHSVSKSSSSNSVYISGTTLAALQPAKSFNYHQGASITSLDFDDAGQFSVSSGIDKSIQLYDCHKGTHSKDIQSQKYGAHSARFTHEELNCLYASTPEPSDNNENAIRYLSLSNNRYLRYFKGHKAQVSSIEVNPVDKTFLSSSYDGTVKLWDLKSSSAVGNLEVGQNSVIGFDPHGVVFAIGKYSQGETGTVSLYDLKTFDKAPFLHVEIPILPGQIWNKLEFSNNGKLILISTDSAEHYVLDSYSGELLAVVRLAIGSVASNNWMSFKYPYTGCCTFSPCGKYLLVGTPKSTINIYDVSNLHNSNNKPVILSRTNHILQSTNGIPKIVSFSPKMFTLATADTTVTLWSPPEKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-05-10" modified="2025-06-18" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Q30</accession>
    <name>GIT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerophosphoinositol permease 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycerophosphodiester transporter GIT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GIT1</name>
        <name type="synonym">GIT99</name>
        <name type="ordered locus">CAALFM_C206590CA</name>
        <name evidence="7" type="ORF">orf19.34</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="373" last="387">
            <title>Property differences among the four major Candida albicans strain clades.</title>
            <authorList>
                <person name="MacCallum D.M."/>
                <person name="Castillo L."/>
                <person name="Nather K."/>
                <person name="Munro C.A."/>
                <person name="Brown A.J."/>
                <person name="Gow N.A."/>
                <person name="Odds F.C."/>
            </authorList>
            <dbReference type="PubMed" id="19151328"/>
            <dbReference type="DOI" id="10.1128/EC.00387-08"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1618" last="1627">
            <title>Robust utilization of phospholipase-generated metabolites, glycerophosphodiesters, by Candida albicans: role of the CaGit1 permease.</title>
            <authorList>
                <person name="Bishop A.C."/>
                <person name="Sun T."/>
                <person name="Johnson M.E."/>
                <person name="Bruno V.M."/>
                <person name="Patton-Vogt J."/>
            </authorList>
            <dbReference type="PubMed" id="21984707"/>
            <dbReference type="DOI" id="10.1128/EC.05160-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="33939" last="33952">
            <title>Glycerophosphocholine utilization by Candida albicans: role of the Git3 transporter in virulence.</title>
            <authorList>
                <person name="Bishop A.C."/>
                <person name="Ganguly S."/>
                <person name="Solis N.V."/>
                <person name="Cooley B.M."/>
                <person name="Jensen-Seaman M.I."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
                <person name="Patton-Vogt J."/>
            </authorList>
            <dbReference type="PubMed" id="24114876"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.505735"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Glycerophosphodiester transporter that mediates uptake of glycerophosphoinositol (GroPIns) as a source of inositol and phosphate (PubMed:21984707, PubMed:24114876). Does not possess detectable glycerophosphocholine (GroPCho) transport activity (PubMed:21984707). Although no glycerophosphoinositol transport activity occurs in the absence of GIT1, C.albicans is still able to use glycerophosphoinositol as a phosphate source at pH 7.5, albeit slowly (PubMed:21984707). Thus, a second, GIT1-independent, mechanism must exist for utilizing glycerophosphoinositol as a phosphate source at physiological pH (PubMed:21984707, PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:21984707). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:21984707, PubMed:24114876).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)</text>
            <dbReference type="Rhea" id="RHEA:32915"/>
            <dbReference type="ChEBI" id="CHEBI:58444"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:32916"/>
        </physiologicalReaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="5">28 uM for glycerophosphoinositol transport</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Phosphate levels regulate glycerophosphoinositol transport activity and transcription factor PHO4 is required for GIT1 expression (PubMed:21984707). Expression profile differs significantly in isolates of high, medium, and low virulence, being the highest in the most virulent strains (PubMed:19151328).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Abolished the utilization of glycerophosphoinositol(GroPIns) as a phosphate source (PubMed:21984707).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711841.1">
        <property type="nucleotide sequence ID" value="XM_706749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Q30"/>
    <dbReference type="SMR" id="Q59Q30"/>
    <dbReference type="FunCoup" id="Q59Q30">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Q30"/>
    <dbReference type="GlyCosmos" id="Q59Q30">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C2_06590C_A-T">
        <property type="protein sequence ID" value="C2_06590C_A-T-p1"/>
        <property type="gene ID" value="C2_06590C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646562"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206590CA"/>
    <dbReference type="CGD" id="CAL0000193792">
        <property type="gene designation" value="GIT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06590C_A"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="Q59Q30"/>
    <dbReference type="OMA" id="RGPIFIL"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015169">
        <property type="term" value="F:glycerol-3-phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001406">
        <property type="term" value="F:glycerophosphodiester transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000439798" description="Glycerophosphoinositol permease 1">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19151328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21984707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="19151328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="21984707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="21984707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="519" mass="57163" checksum="896615C246109D9D" modified="2005-04-26" version="1">MSDLVKSSEVIETTEVPPHNNNNNKRHFKYDSEQRKQRLAGGVKLKDALMILCAGFALISDGYQNNVMSMMNKVFALEYPKEYTASLSTQVSNASLVGTIFGQVIIGLTADYIGRKWSIVTATCFLIFGTMMCAASHGKTVNGMFWMLTIFRGVTGFGIGAEYPSSSVTASEAANESVKRRGGAFILATNLPLSFGGPFALCIFLIVRRICGNHLDAIWRTMFAIGCFWPLSVFYFRLKMVTSELYTKSAIKQRAPYWLALKYYWPRLIGTCVAWFLYDFVTFPNGIFSAGIISNVIPKSEKNNLEKIAEWNLLLGAIALPGVFVGAYVVDILGRKYTMMIGFCGYIVFGLIVGCGYHQIKPITGLFIVFYGLMMSCGNFGPGNNMGLTSSESFATPIRGTAYGISAAIGKVGAVVGTKTFSPIQKNLGDKWTFIIAAICGLAGVLVTFIFIPHLKDEDLLEEDVKFKNYLIDNGWKGKFGIQEYDEEEDLEGSSEDSSDGEIVKNNTKNDVEKVDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Q34</accession>
    <name>Q59Q34_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ion-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">SPF1</name>
        <name evidence="16" type="ordered locus">CAALFM_C206540CA</name>
        <name evidence="15" type="ordered locus">orf19.7701</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711837.1">
        <property type="nucleotide sequence ID" value="XM_706745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Q34"/>
    <dbReference type="SMR" id="Q59Q34"/>
    <dbReference type="FunCoup" id="Q59Q34">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Q34"/>
    <dbReference type="GeneID" id="3646573"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206540CA"/>
    <dbReference type="CGD" id="CAL0000181174">
        <property type="gene designation" value="SPF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06540C_A"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="InParanoid" id="Q59Q34"/>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140569">
        <property type="term" value="P:extraction of mislocalized protein from ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000128">
        <property type="term" value="P:flocculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032995">
        <property type="term" value="P:regulation of fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055092">
        <property type="term" value="P:sterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="253"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000181174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1223" mass="136961" checksum="544AD1A31DD9EEA0" modified="2005-04-26" version="1">MSDLVANPAIQGAELLVPKAVFLRPYVWPFSIIYPIFLQIYFQQYDKYIGGKEWTFVYTIAIVSVNLLFWLMPHWNIDINAKFNYTKVDKISDASYIKITPAPNSGMGEICEINRETFHDGEKQVSFLYQKRRYLFHSKIGKFSPPEFVFDEAPKLAVYQNTKGLSGDLEKMIRNYGSNRFDIPIPTFMELFKEHAVAPFFVFQIFCVALWCMDEQWYYSLFSLFMLVSFEMTTVFQRRTTMAEFQSMGIKPYDVYAYRDGKWVKIPTTDLLPGDLISITRTNEGSALPCDLLLVDGSAIVNEAMLSGESTPLLKESIKLRPADEQLQPEGFDKNSILHGGTMALQVTKPESPIVPVAPDNGAFAVVTKTGFETSQGSLVRMMIFSSERVSVGNKEAFFFILFLLIFAIAASWYVWVEGTRMGRIQSKLILDCIIVITSVVPPELPMELTMAVNSSLSKLQKFYIYCTEPFRIPLAGRIDVCCFDKTGTLTAEDLVFEGLAGFKNDDIHHLHICEDAPETTSYVLGSAHALVRLDDGEVVGDPMEQATLKAAHWNVGTHDTVERESKKGKGKSEKIKILRRFQFSSALKRSSTISQINTISGKNFVAAKGAPETIRNMIVDAPENYEKIYKSFTRSGSRVLALAYKYLESSVNVNKVKREDIESDLHFAGFIVFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTACHVAKEVNITTKEVLILDAPEDHHEIGEYDNLVWRNVTESVVIPFKSSDKINLELFSKYDICITGYALNYLSDHEQILELLKHTWVYARVSPTQKEFIITSLKDAGYNTLMCGDGTNDVGALKQANIGVALLNGTEEGMNKIAENRKIEATLKVYEKQSQIFNNWGKPAPPVPAIIAHLYPPGPLNPKYLEAMEKKGVTITDDMRKAVVEAMKEPVKVPEKNAANGGFNTNSNFADTILGAMNDAEAEDEAPVLKLGDASVAAPFTSKLANVNTVTHIIRQGRVALVSTIQMYKILALNCLISSYSLSVLYLAGMKFGDGQATISGILLSVCFLSISRGRPLEKLSKERPQDGIFNIYIMGSILGQFAVHIITLIYITREIYILEPREPKVDLEKEFSPSLLNTGMFLLQLAQQVSTFAVNYIGLPFRESITSNKGMYYGLLGVAGLTFSCSTEFIPELNEVMQFVPMTIDFKTKLTGCIILDLVVTFAIEYVLKYFFMNSKAADIALREEDEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SI6</accession>
    <name>Q59SI6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">PCT1</name>
        <name evidence="15" type="ordered locus">CAALFM_C400570CA</name>
        <name evidence="14" type="ordered locus">orf19.11663</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712640.1">
        <property type="nucleotide sequence ID" value="XM_707547.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SI6"/>
    <dbReference type="SMR" id="Q59SI6"/>
    <dbReference type="FunCoup" id="Q59SI6">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SI6"/>
    <dbReference type="GeneID" id="3645743"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400570CA"/>
    <dbReference type="CGD" id="CAL0000199421">
        <property type="gene designation" value="PCT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00570C_A"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_0_1_1"/>
    <dbReference type="InParanoid" id="Q59SI6"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="124"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000199421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="457" mass="53059" checksum="A28F4140126B3C43" modified="2005-04-26" version="1">MARLTRKRTIEKELNGSSRVTRTLSMESISSLFKRNKKRKHNDGNDSSVNSSDNENINITDDEEQDHIDTKPNHKKRKIKTKAEEEFEANEKKLDEELPIDLRKYRPRGFRFNLPPEDRPIRIYADGVFDLFHLGHMKQLEQAKKSFPNVELVCGIPSDIETHKRKGLTVLTDEQRCETLMHCKWVDEVIPNAPWCVTPEFLQEHKIDYVAHDDLPYASSDSDDIYKPIKEQGKFLTTQRTEGISTSDIITKIIRDYDKYLMRNFSRGATRKELNVSWLKMNELEFKKHINDFRTYWMKNKTNINNVSRDLYFEIREFMRGKKFDFQKFIEDGNSQNSSNHGSDEESTNSSKVSSPLSDFASKYIGNRNKDLNRKGILNNFKGWINRDDHSEQETEEEIKPIVIKPIRRSRRLSGGSSTSSVPSTPVKRTASSASTTPKRKSPLKKSSSVKNTPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SM8</accession>
    <name>Q59SM8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">MIS11</name>
        <name evidence="26" type="ordered locus">CAALFM_CR07010WA</name>
        <name evidence="25" type="ordered locus">orf19.9900</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:23701"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:23702"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:22813"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:22814"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:20222"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:20223"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712654.1">
        <property type="nucleotide sequence ID" value="XM_707561.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SM8"/>
    <dbReference type="SMR" id="Q59SM8"/>
    <dbReference type="FunCoup" id="Q59SM8">
        <property type="interactions" value="1282"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SM8"/>
    <dbReference type="GeneID" id="3645732"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07010WA"/>
    <dbReference type="CGD" id="CAL0000181460">
        <property type="gene designation" value="MIS11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07010W_A"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="InParanoid" id="Q59SM8"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 26" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="23">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="24">
        <location>
            <begin position="143"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051435"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051544"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052163"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="CGD" id="CAL0000181460"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="AOW31396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="946" mass="102179" checksum="A28597F693F9FEC3" modified="2005-04-26" version="1">MVAELIDGKAIALDLRTKIHDDIAQFQLKHPEFKPHLSIIQVGDRPDSNTYVKMKLKAAEEASIGCELIKLPEDISQFELLSKIEKLNNSLDVDGILVQLPLPEHIDETKITDAVLANKDVDGFGPFNVGELAKKGGEPLFLPCTPKGIMHLFEKSKIDLEGKDVVVLGRSDIVGKPIARLLTKANANVTVVHSKTPLDKLKNYLGDADIVVAAIGQPQFVKGEWLKDGVVVIDVGTNFIPDASKKSGQRMVGDVDFESAKTKASFITPVPGGVGPMTVACLLDNVVIGAKKHYKANNETPKFTNPLKLHLQKPVPSDFEISRAQQPKRITQVAEEAGILDAELEPFGFYKAKVSLDILKRLNNKVNGKYVLVTGITPTPLGEGKSTTTVGLAQALGAHLKKNVFANVRQPSMGPTFGIKGGAAGGGYSQVIPMDEFNMHVTGDIHAITMANNLLAAAIDTRMFHESTQKDGPLYRRLVPEKKGVRKFTPSMLRRLEKLGINKTDPNELTPEEITQFARLDIDPESITWRRVVDCNDRFLRGITVGQAPTEKGFTRATGFDITVASECMAILALANSLEDMRERLGKMVIGSSKAGIPITCEDIGCAGALTALLKDAIKPNIMQTLEGTPVFVHAGPFANISIGASSILADKMALKLAGTSSELSEEERKEQEGYVVTEAGFDFTMGGERFINIKCRSSGLVPDVIVIVATVRALKVHGGGPEVKAGAPLAPEYTQENVELLRKGCSNLAKHIANAKSYGLPVVVAINKMSSDSDKEHEVIREEALKAGAVDAIVSNHWEEGGKGAVDLAQGVINAANSPDKNFNFLYGLEPSVEEKISTIAKEMYGAGEVEFLPEAQKKIDLYTKQGFGKLPICIAKTQYSLSHDANLKGVPTGFKFPIRDVRASIGAGYLYALAAEIQTIPGLPTHCGFMNVEVNEDGEIDGLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VQ8</accession>
    <accession>A0A1D8PD27</accession>
    <accession>Q59VV4</accession>
    <name>WAR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator WAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Weak acid resistance protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">WAR1</name>
        <name type="ordered locus">CAALFM_C103740WA</name>
        <name type="ORF">CaO19.1035</name>
        <name type="ORF">CaO19.8637</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Microbiol. Mol. Biol. Rev." volume="70" first="583" last="604">
            <title>A fungal family of transcriptional regulators: the zinc cluster proteins.</title>
            <authorList>
                <person name="MacPherson S."/>
                <person name="Larochelle M."/>
                <person name="Turcotte B."/>
            </authorList>
            <dbReference type="PubMed" id="16959962"/>
            <dbReference type="DOI" id="10.1128/MMBR.00015-06"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Yeast" volume="23" first="249" last="259">
            <title>New tools for phenotypic analysis in Candida albicans: the WAR1 gene confers resistance to sorbate.</title>
            <authorList>
                <person name="Lebel K."/>
                <person name="MacPherson S."/>
                <person name="Turcotte B."/>
            </authorList>
            <dbReference type="PubMed" id="16544288"/>
            <dbReference type="DOI" id="10.1002/yea.1346"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Eukaryot. Cell" volume="7" first="268" last="278">
            <title>CTA4 transcription factor mediates induction of nitrosative stress response in Candida albicans.</title>
            <authorList>
                <person name="Chiranand W."/>
                <person name="McLeod I."/>
                <person name="Zhou H."/>
                <person name="Lynn J.J."/>
                <person name="Vega L.A."/>
                <person name="Myers H."/>
                <person name="Yates J.R. III"/>
                <person name="Lorenz M.C."/>
                <person name="Gustin M.C."/>
            </authorList>
            <dbReference type="PubMed" id="18083829"/>
            <dbReference type="DOI" id="10.1128/EC.00240-07"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 7">Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide-responsive element (NORE) but does not seem to be involved in response to nitrosative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Expression is induced in biofilm.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 7">Leads to sensitivity to weak organic acids and decreases cell adherence to silicone substrate.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713640.2">
        <property type="nucleotide sequence ID" value="XM_708547.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VQ8"/>
    <dbReference type="FunCoup" id="Q59VQ8">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VQ8"/>
    <dbReference type="EnsemblFungi" id="C1_03740W_A-T">
        <property type="protein sequence ID" value="C1_03740W_A-T-p1"/>
        <property type="gene ID" value="C1_03740W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644691"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103740WA"/>
    <dbReference type="CGD" id="CAL0000177698">
        <property type="gene designation" value="WAR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03740W_A"/>
    <dbReference type="eggNOG" id="ENOG502QRSG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004837_1_0_1"/>
    <dbReference type="InParanoid" id="Q59VQ8"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="PRO" id="PR:Q59VQ8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071311">
        <property type="term" value="P:cellular response to acetate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000426087" description="Transcriptional regulator WAR1">
        <location>
            <begin position="1"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16544288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18083829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <sequence length="947" mass="105854" checksum="9DAA645E36D94C01" modified="2017-03-15" version="2">MSDTTPEKGSVDSVSPSASNGSNTNNPLNNSSPQPLKSNESDKKPKVTRRSVACKSCHSLKVKCTPSDPNNPSAPCVRCINANRICEIDLNQTRKRRKKSEILEAKRQAGQSLPEHKKEKNTPTQSGYNSSENYSSSINNANDSSLTSRYQSPMTFDPTSPMVFRPQASSAVPPISSNLNPQSAAPTPIPTSGIPPQLPSPHESAILRGNTTSPTSKDDEINQLKQRVRFLETELANKRLLANKKGFSNDSPTDLQSPPFVSKFDLESEISILAESSARLTDLTNQLNEAASRRIQLVSAKKPVDLISKGVITVAEAEERLKLYREQIYGRHPLIAIPDNMHAIEFSQSQPFLFNSIMSACNLITKNADKDVVLAIDNEAMTSVAVEVMVVGTKSVELVKAFSVLCLYYNSPELFKQRRYHMLNTICVSLLHDVGIFARPTYSYNQADGTLKQDASSKDKGNDEYRELVLITYFVTVSTCLVLRRSIYARWTPYVEECCSLLENSSQEKHRRLALFARMNNKLDKIHHIVHAPEMPGQKSGVSQYVIQELQRLLSDLKLKIKDNQYSLLSYYYSIEAYLHEPILTKVFKSDTELDGKAMKSIRYCTSSCLNALDEYSKLTPDQIALLPFPFGSRIMYTAGMLLRLRYLILSLPSHIDKELVPKRAVTSIQCVSKLVEQANILNPHNHYLTKMRLVLQLFIQTYATQVLELLSKNGNTPQNFKPDESETQQLRALAREYNDIRKVSKVSLVSDTRSAEPLDVLSYAATFRRENNDKPSAVAGSLRKSFSENDQAIKTPSQCGQFVSANNTPVPQVINSPPISQTNVPVLHQSQSIINGNNRNSAPLAFNNTTTPSLHQFGDVLPPSSMPQPDYRQFRLPSISNTVHYSSNPRLNANLANPDQLENSYQVLNDEFWSNLLSTDSTDRINFTSNNFNGNTSNDEVFFMNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VW7</accession>
    <accession>A0A1D8PCR1</accession>
    <name>TIM21_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM21</name>
        <name type="synonym">FMP17</name>
        <name type="ordered locus">CAALFM_C102350WA</name>
        <name type="ORF">CaO19.11175</name>
        <name type="ORF">CaO19.3691</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713785.1">
        <property type="nucleotide sequence ID" value="XM_708692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VW7"/>
    <dbReference type="SMR" id="Q59VW7"/>
    <dbReference type="FunCoup" id="Q59VW7">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VW7"/>
    <dbReference type="EnsemblFungi" id="C1_02350W_A-T">
        <property type="protein sequence ID" value="C1_02350W_A-T-p1"/>
        <property type="gene ID" value="C1_02350W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644573"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102350WA"/>
    <dbReference type="CGD" id="CAL0000180033">
        <property type="gene designation" value="TIM21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02350W_A"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089043_0_0_1"/>
    <dbReference type="InParanoid" id="Q59VW7"/>
    <dbReference type="OMA" id="HVESKQK"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="PRO" id="PR:Q59VW7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043142" description="Mitochondrial import inner membrane translocase subunit TIM21">
        <location>
            <begin status="unknown"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin status="unknown"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="127"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="268" mass="30085" checksum="F0DE4D6D3220A6BD" modified="2005-04-26" version="1" precursor="true">MHMIQRVSSIGLRTLRSSNIGSIRSLIVLPILSIKPTYIRQTQAQINLKPQALLLNLLLHHHHHHHHYYSTKTAPPPPPPPQPPQDKNAKGKKILNRINRAFTFSLSTLLVVGAAGISVLVVSLILSELFLPSGDTRTFNKAVKLIEKNEQAQKALNFQSGQRLKAYGIVSADKWVRNRPVQSVKTKRKDGKDHLIMKFQVESDNGKYGVVSLEQIDNSMWNTEFEYISLDVPGFKRIYIIEPPKNQLIPKIGGGSGFLGLNWGPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WC9</accession>
    <name>Q59WC9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">SEC34</name>
        <name evidence="13" type="ordered locus">CAALFM_C107270WA</name>
        <name evidence="12" type="ordered locus">orf19.11920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713884.1">
        <property type="nucleotide sequence ID" value="XM_708791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WC9"/>
    <dbReference type="SMR" id="Q59WC9"/>
    <dbReference type="FunCoup" id="Q59WC9">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WC9"/>
    <dbReference type="GeneID" id="3644455"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107270WA"/>
    <dbReference type="CGD" id="CAL0000188287">
        <property type="gene designation" value="SEC34"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07270W_A"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011639_2_0_1"/>
    <dbReference type="InParanoid" id="Q59WC9"/>
    <dbReference type="OMA" id="DEFELWG"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="120"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="292"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="797"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="803"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000188287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW26379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="839" mass="96476" checksum="8FDA6F9AB014AE82" modified="2005-04-26" version="1">MTRGRSKSIVQKIANDVPKLNNSENALDYLLKENGGENNLTHTSTTYKMSRSKSLSQEGRNNNMELEKVHYADSITYPFTKSEFQKAESDNINSYDYDTILKPRDISHITDLQLDNILNFKNMVQRNKVEIEVFVSETNDVLSSVETLLSKYNRISNETLDFDKRANELLELQKHNQTKYDEINSYLQHFEQLDFITKNLSRSGSHLLSSKREFFINVVLRKLDTALDFIAQHPSFKESEVYGSRFRQCMTRALTLIKNYLNNELKSVADSINKKLHQNMSDSHSVSLTIDLLIYNEYNSYLKYNQSNFNELICEMQKRAQNHSEYNGLIEEVLNKYFEDRLVLLREYIDKTSSVNSVFTGSNLDLVQTCQDQIYYFEKLIEREYSLFNKFFVPGQSAEYIERAFYEFLKKVLEPLYDAERLLVLKESNIGSLCQLTTLLQKYYEFDDGNYRSDVYLEDANSSVAANGKSIKYGVLFQPLLDETQERLIFRVQNYVDNKLMHFKPSASDLKIGNTLKRSSGAEDKINPLDVDYAENLFPDLYLPLGKSLTLLSNIYELINSMVFDDLAHYIVHACIELLKGGFLPLAIGHMGPIDGQLVYLNNLVILRNQINNFDIQYTRTDYTIDFTSGLSDIWQLIKDRKFGFNNGGILDLASRAAPKIINNMIDANYEIEFELRNAVTQFIDECSRTICYPLLVHDSESGNLVAVTSAFKDNLISNIPVYYGRIKSVIKDPVVTQFLMSNLSSLLVATYEDYYNKIDEKSETMDVLSKDQLNDIMDVDTTYAFITDMITQLGDDSESKSKANTPEFNEEILSSLQLDEPISTSKPASPKTELADPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WJ3</accession>
    <name>Q59WJ3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phosphofructo-2-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C111080WA</name>
        <name evidence="5" type="ordered locus">orf19.9844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713913.1">
        <property type="nucleotide sequence ID" value="XM_708820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WJ3"/>
    <dbReference type="SMR" id="Q59WJ3"/>
    <dbReference type="STRING" id="237561.Q59WJ3"/>
    <dbReference type="GeneID" id="3644416"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111080WA"/>
    <dbReference type="CGD" id="CAL0000192951">
        <property type="gene designation" value="orf19.9844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11080W_A"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041936_1_0_1"/>
    <dbReference type="InParanoid" id="Q59WJ3"/>
    <dbReference type="OMA" id="SSHLIQC"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003915">
        <property type="entry name" value="6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="125"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000192951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="361" mass="41632" checksum="0CD4B9256AD68DE6" modified="2005-04-26" version="1">MTHTERQKVTFEFFDNTSHQMQRNKLKQLPPLSTDIESSSSPHSPSGADLRFISSSSSINSLFDSVPLYSRTASTTTITPILSRHDSNPGFKNNYHNLLHHPTIQELDFTQTIDLKLRQHQSCTTSAQPKEKLILLLVGLPASGKSTICKQFQEFINENSEYNAQIYNAGDVRRRRSASEFNDAQFFDPNNEQGKKDRELYATITVNNLINDLQSNVIDVGFLDATNTTLERRQRMINLINEQVPNGRIVIFDVQCNNQKLLEYNISGKSENNDYKNKDYTTAINDFKQRAMNYKKIYKPITEEELASYGDKVDMYMKCVNGGQQFEFSHIHHADTWYYKILSDFKSNYKLSEVYRELLGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XM1</accession>
    <accession>A0A1D8PPK5</accession>
    <accession>Q59WR9</accession>
    <name>EXO84_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EXO84</name>
        <name type="ordered locus">CAALFM_C601280WA</name>
        <name type="ORF">CaO19.135</name>
        <name type="ORF">CaO19.7779</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
        <text evidence="1">Cell periphery. The polarization of EXO84 requires actin cables (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714341.2">
        <property type="nucleotide sequence ID" value="XM_709248.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XM1"/>
    <dbReference type="BioGRID" id="1227116">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59XM1">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59XM1"/>
    <dbReference type="EnsemblFungi" id="C6_01280W_A-T">
        <property type="protein sequence ID" value="C6_01280W_A-T-p1"/>
        <property type="gene ID" value="C6_01280W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644022"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601280WA"/>
    <dbReference type="CGD" id="CAL0000174176">
        <property type="gene designation" value="EXO84"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01280W_A"/>
    <dbReference type="HOGENOM" id="CLU_024067_0_0_1"/>
    <dbReference type="InParanoid" id="Q59XM1"/>
    <dbReference type="OMA" id="TDRYDHF"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="PRO" id="PR:Q59XM1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1210:FF:000009">
        <property type="entry name" value="Exocyst complex component EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0268">Exocytosis</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000118978" description="Exocyst complex component EXO84">
        <location>
            <begin position="1"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="521"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="791" mass="88593" checksum="19842E278F76A738" modified="2017-03-15" version="3">MDNLDPNSSLQVEKLRNRKSRAVWQNNNTTTHNNPYANLSTGEKSRSRHNTGSSYVSPYGGGNGEENAYTGNNNKSNTSGNLLQVPGAGGGGDLNSNKKQSRRMSIHVSARQHGRSFSQTGPIDMANLPALPKIGGVTTSGVGGAGGDVMTRTGGLTIEQKIFKELSQGSAAEVDDYYKTLLKQKNLITRDIKDNINQNQKNILQLTKDLKETQEELIELRGTTKELYEVLGYFKESAQRRLELEFEPETQKELHSPQKSNQLGIPSNKKKDRSSIMVLKKMWDSQLQSLFKHVDGASKFVQPLPNRHIVAESGRWFEVNVGNWKPSYPTHLFIFNDLILIAVKKSSSSSQEPTTGGSNGGSKSRLQAVQCWPLTQVSLQQIKSPKKDDDKMYFINLKSKSLSYVYSTDRYDHFVKVTEAFNKGRNEMIQSERLLDSRLSSPSNNNGDSKEEKRQLRESLRNSGNYKEGVTDDAGGAATGGGRKSAGTPNRNSTDYVLHDISARVHSRNRSQDLGNNFKLANNGKSQFFNEIKTLEDRLDDVDVEISHNQYAEAVELISIIESKLRNIENALTNQRNGGKNVNIADELLLLDVSKLKIKNRKENVSNGLIFDLQHNIAKLKQDDIDNILTLFDNLEQLDRGVQGYLDSMSAYLSTTVSKLIVGLQGSTKIDVVNYLSNLMVINVSIVKRTIQTYEQIIAPILKRHGDVDSSGLINWCIDEFTKLCKQIKKHLYGTLLISSGINMETDEPIYKVKERKLYDNFLKIMQPQLEELKSVGLNVDYIFESILNLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XQ1</accession>
    <accession>A0A1D8PPJ0</accession>
    <accession>Q59WU6</accession>
    <name>HAL22_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>3'(2'),5'-bisphosphate nucleotidase 2</fullName>
            <ecNumber evidence="1">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DPNPase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Halotolerance protein HAL22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HAL22</name>
        <name type="synonym">MET221</name>
        <name type="ordered locus">CAALFM_C601030WA</name>
        <name type="ORF">CaO19.105</name>
        <name type="ORF">CaO19.7752</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphatase that converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714314.2">
        <property type="nucleotide sequence ID" value="XM_709221.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XQ1"/>
    <dbReference type="SMR" id="Q59XQ1"/>
    <dbReference type="FunCoup" id="Q59XQ1">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59XQ1"/>
    <dbReference type="EnsemblFungi" id="C6_01030W_A-T">
        <property type="protein sequence ID" value="C6_01030W_A-T-p1"/>
        <property type="gene ID" value="C6_01030W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644051"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601030WA"/>
    <dbReference type="CGD" id="CAL0000200084">
        <property type="gene designation" value="HAL22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01030W_A"/>
    <dbReference type="HOGENOM" id="CLU_033446_2_1_1"/>
    <dbReference type="InParanoid" id="Q59XQ1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="PRO" id="PR:Q59XQ1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000245648" description="3'(2'),5'-bisphosphate nucleotidase 2">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="358" mass="38753" checksum="F3DF0EAD31657902" modified="2017-03-15" version="3">MSHSTHPYQKELEVATLAVKRASLLTKQLSDSIVQTAKSGTLTKDDKSPVTIGDFASQAIINHAIKLNFPNDEIVGEEDSRELQENTGLADQMLQLITKIQKETSGYNDIVGTLTDKNEVYQSIDFGNSQGGSKGRFWALDPIDGTKGFLRGDQFAVCLALIEDGKVVLGVIGCPNLSENIVSNEEHSGVVGGLYSAVKGVGSFYSELFKEGAEPLSQQKRIKMQNHTNPSQLKVVEGVEKGHSSHSTQTEIKAKFGFDSATVAKQTINLDSQVKYCVLASGQADIYLRLPVNETYREKIWDHAAGNILIYESGGQVGDVTGSPLNFGNGRTLDSKGVIAANKGIFDKVIDAVTEVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZD9</accession>
    <name>Q59ZD9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C205510CA</name>
        <name evidence="6" type="ordered locus">orf19.11065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714940.1">
        <property type="nucleotide sequence ID" value="XM_709847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZD9"/>
    <dbReference type="SMR" id="Q59ZD9"/>
    <dbReference type="FunCoup" id="Q59ZD9">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZD9"/>
    <dbReference type="GeneID" id="3643420"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205510CA"/>
    <dbReference type="CGD" id="CAL0000187423">
        <property type="gene designation" value="orf19.11065"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05510C_A"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="InParanoid" id="Q59ZD9"/>
    <dbReference type="OMA" id="MPQNPDV"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000187423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="435" mass="49281" checksum="73FA37F31156F4B1" modified="2005-04-26" version="1">MSTTTDTIDLTNDGSEKINEVDNIHEDTPVEESAIDEKTQQNYRVWKKNAPLLYDYLVTNSLLWPSLSVQFFPDITHINDLGENKNEEQIIAQRILLGTFTLGQAIDHISILQIPSFKNLNQNIKINKLDFNPEREEFELTTPSLNKTKTLQKINHLGDVNKVRYMPQKPNILASANNLGNLVIYERTRHKSFKNTILDDTDLSKVQVRLVNKHIPSTTDIFAIDWNRNSEGLLLSADMNGLVNLYDLKKYESETLNESQYWENNAIGVNDIEWFPTHDSLFCTADDNGWLKLYDTRNQSAAVQNANIGNSVNSVACNPGYATGLATGDSNGVIKMWDIRNFDNSLSELHGHSDSVTQLKWNPKCHNILGSSSSDHSVKLHDMSNDSTIFTHLGHMLGVNDFDWSYADPWMVASVADDNSLHVWKPTHSVTDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZG1</accession>
    <name>Q59ZG1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C205290CA</name>
        <name evidence="12" type="ordered locus">orf19.11042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714917.1">
        <property type="nucleotide sequence ID" value="XM_709824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZG1"/>
    <dbReference type="SMR" id="Q59ZG1"/>
    <dbReference type="FunCoup" id="Q59ZG1">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZG1"/>
    <dbReference type="GeneID" id="3643472"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205290CA"/>
    <dbReference type="CGD" id="CAL0000195459">
        <property type="gene designation" value="orf19.11042"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05290C_A"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="InParanoid" id="Q59ZG1"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EMP24_GP25L"/>
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    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
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    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
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    <feature type="chain" id="PRO_5009971198" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="213"/>
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            <begin position="179"/>
            <end position="205"/>
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            <dbReference type="CGD" id="CAL0000195459"/>
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            <dbReference type="EMBL" id="AOW27545.1"/>
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    </evidence>
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    <accession>Q59ZX3</accession>
    <accession>A0A1D8PFU5</accession>
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        <recommendedName>
            <fullName>Repressed by EFG1 protein 1</fullName>
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        <alternativeName>
            <fullName>PRY family cell wall protein 2</fullName>
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    <gene>
        <name type="primary">RBE1</name>
        <name type="synonym">PRY2</name>
        <name type="ordered locus">CAALFM_C114120CA</name>
        <name type="ORF">CaO19.7218</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
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                <person name="Scherer S."/>
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                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Mol. Microbiol." volume="47" first="89" last="102">
            <title>EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays.</title>
            <authorList>
                <person name="Sohn K."/>
                <person name="Urban C."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="12492856"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2003.03300.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="54" first="1335" last="1351">
            <title>Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p.</title>
            <authorList>
                <person name="Bensen E.S."/>
                <person name="Martin S.J."/>
                <person name="Li M."/>
                <person name="Berman J."/>
                <person name="Davis D.A."/>
            </authorList>
            <dbReference type="PubMed" id="15554973"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04350.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2913" last="2925">
            <title>Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.</title>
            <authorList>
                <person name="Garcia-Sanchez S."/>
                <person name="Mavor A.L."/>
                <person name="Russell C.L."/>
                <person name="Argimon S."/>
                <person name="Dennison P."/>
                <person name="Enjalbert B."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15814841"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-01-0071"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2010" name="J. Proteomics" volume="73" first="1404" last="1409">
            <title>Identification of Candida albicans exposed surface proteins in vivo by a rapid proteomic approach.</title>
            <authorList>
                <person name="Hernaez M.L."/>
                <person name="Ximenez-Embun P."/>
                <person name="Martinez-Gomariz M."/>
                <person name="Gutierrez-Blazquez M.D."/>
                <person name="Nombela C."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="20167299"/>
            <dbReference type="DOI" id="10.1016/j.jprot.2010.02.008"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2010" name="Eukaryot. Cell" volume="9" first="1734" last="1746">
            <title>Regulation of the hypoxic response in Candida albicans.</title>
            <authorList>
                <person name="Synnott J.M."/>
                <person name="Guida A."/>
                <person name="Mulhern-Haughey S."/>
                <person name="Higgins D.G."/>
                <person name="Butler G."/>
            </authorList>
            <dbReference type="PubMed" id="20870877"/>
            <dbReference type="DOI" id="10.1128/EC.00159-10"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2010" name="Yeast" volume="27" first="661" last="672">
            <title>Mass spectrometric analysis of the secretome of Candida albicans.</title>
            <authorList>
                <person name="Sorgo A.G."/>
                <person name="Heilmann C.J."/>
                <person name="Dekker H.L."/>
                <person name="Brul S."/>
                <person name="de Koster C.G."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="20641015"/>
            <dbReference type="DOI" id="10.1002/yea.1775"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1071" last="1081">
            <title>Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.</title>
            <authorList>
                <person name="Sorgo A.G."/>
                <person name="Heilmann C.J."/>
                <person name="Dekker H.L."/>
                <person name="Bekker M."/>
                <person name="Brul S."/>
                <person name="de Koster C.G."/>
                <person name="de Koning L.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="21622905"/>
            <dbReference type="DOI" id="10.1128/EC.05011-11"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2011" name="Cell Host Microbe" volume="10" first="118" last="135">
            <title>An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.</title>
            <authorList>
                <person name="Chen C."/>
                <person name="Pande K."/>
                <person name="French S.D."/>
                <person name="Tuch B.B."/>
                <person name="Noble S.M."/>
            </authorList>
            <dbReference type="PubMed" id="21843869"/>
            <dbReference type="DOI" id="10.1016/j.chom.2011.07.005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Mol. Microbiol." volume="87" first="132" last="151">
            <title>A family of secreted pathogenesis-related proteins in Candida albicans.</title>
            <authorList>
                <person name="Rohm M."/>
                <person name="Lindemann E."/>
                <person name="Hiller E."/>
                <person name="Ermert D."/>
                <person name="Lemuth K."/>
                <person name="Trkulja D."/>
                <person name="Sogukpinar O."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
                <person name="Urban C.F."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="23136884"/>
            <dbReference type="DOI" id="10.1111/mmi.12087"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell wall protein involved in cell wall integrity and which plays a role in virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7 10 12">Secreted</location>
            <location evidence="6 7 10 12">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5 7 8 9 10 11 12">Induced by ketoconazoland fluconazole; and repressed by EFG1, RIM101, SSN6, and alkaline conditions. Enriched in the media of yeast form-containing cultures. Expression is also regulated by HAP43, SEF1, and SFU1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_715019.1">
        <property type="nucleotide sequence ID" value="XM_709926.1"/>
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    <dbReference type="STRING" id="237561.Q59ZX3"/>
    <dbReference type="GlyCosmos" id="Q59ZX3">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_14120C_A-T">
        <property type="protein sequence ID" value="C1_14120C_A-T-p1"/>
        <property type="gene ID" value="C1_14120C_A"/>
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    <dbReference type="GeneID" id="3643317"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114120CA"/>
    <dbReference type="CGD" id="CAL0000190649">
        <property type="gene designation" value="RBE1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_14120C_A"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_035730_3_0_1"/>
    <dbReference type="InParanoid" id="Q59ZX3"/>
    <dbReference type="OMA" id="WRTINIV"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.33.10:FF:000012">
        <property type="entry name" value="Secreted protein PRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
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    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
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    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
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    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
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    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
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    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424913" description="Repressed by EFG1 protein 1">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SCP">
        <location>
            <begin position="128"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12492856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15554973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15814841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="20167299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="20641015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="20870877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="21622905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="21843869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="23136884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <sequence length="271" mass="29078" checksum="7A453B25C4C10D67" modified="2005-04-26" version="1" precursor="true">MKITNTLLNAAALLAVTEAATITKFFTASTQTLFVTQTSQTVVATKSFVETIYSAPPKQLTSKTQDSTSPTTSSVNSLTSSSATSYVETTTPAPSSSTLTTSTISSSTASEDSDATPTADVEFAEEILKEHNVKRALHGVPALSWSNKLAEYAQDYANTGFDCSNLNLKHSGGPYGENLAAGYMGGISPVDAWYDEISMVDWNNVDFTESTGHFTQLVWRSTTQVGCAKMMCSTAWRQITVCEYLPRGNVIGLNVTSGHSYFVDNVLPPLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0W6</accession>
    <accession>A0A1D8PMN3</accession>
    <name>GPN3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPN-loop GTPase 3</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C406790WA</name>
        <name type="ORF">CaO19.10642</name>
        <name type="ORF">CaO19.3130</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Small GTPase involved in the correct assembly of RNA polymerase II and III (RNAPII and RNAPIII) complexes, ensuring their proper nuclear import of RNAPII. Promotes sister chromatid separation during anaphase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715439.2">
        <property type="nucleotide sequence ID" value="XM_710346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0W6"/>
    <dbReference type="SMR" id="Q5A0W6"/>
    <dbReference type="BioGRID" id="1225934">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A0W6">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0W6"/>
    <dbReference type="EnsemblFungi" id="C4_06790W_A-T">
        <property type="protein sequence ID" value="C4_06790W_A-T-p1"/>
        <property type="gene ID" value="C4_06790W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642918"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406790WA"/>
    <dbReference type="CGD" id="CAL0000198582">
        <property type="gene designation" value="orf19.10642"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06790W_A"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A0W6"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="PRO" id="PR:Q5A0W6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52071">
        <property type="entry name" value="GPN_LOOP_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255588" description="GPN-loop GTPase 3">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="GPN-loop core GTPase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G1" evidence="4">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G2" evidence="4">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-Pro-Asn (GPN)-loop; involved in dimer interface" evidence="3 4">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G3" evidence="4">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G4" evidence="4">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G5" evidence="4">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Stabilizes the phosphate intermediate; shared with dimeric partner" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P47122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q06543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9UYR9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="273" mass="30867" checksum="8DCF8D40584B4314" modified="2006-10-31" version="2">MSRTGVLVLGPAGVGKSTFCNSMIAYMQSIGRRAHIVNLDPAANPTEYEFTIDVKDLISLQDVMEEMELGPNGGLVYCFEFLLNNLDWLDEEIGDYNDEYLIFDCPGQIELYTHIPVLPTIVRHLQTSLNFNLCATYLLEAPFIIDNSKFFSGALSAMSAMILLELPHINILSKIDLVKDEYSKKQLKKFLNPDPLLLAKQEDYINPKFAKLTQSIANLVDDFGMVQFLPLDCSKDSRSVETILSYIDDVTQWSEAQEPKEPHDEVELPDEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A107</accession>
    <name>Q5A107_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C407140WA</name>
        <name evidence="2" type="ordered locus">orf19.10601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715399.1">
        <property type="nucleotide sequence ID" value="XM_710306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A107"/>
    <dbReference type="SMR" id="Q5A107"/>
    <dbReference type="FunCoup" id="Q5A107">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A107"/>
    <dbReference type="GeneID" id="3642936"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407140WA"/>
    <dbReference type="CGD" id="CAL0000184136">
        <property type="gene designation" value="orf19.10601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07140W_A"/>
    <dbReference type="eggNOG" id="KOG3336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A107"/>
    <dbReference type="OMA" id="YCPWNEK"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036164">
        <property type="term" value="P:cell-abiotic substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000184136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="194" mass="22388" checksum="0032D6DDE6227C39" modified="2005-04-26" version="1">MKLFESEHSFNYPWDQVTAANWQKYPNELASHVISVDILQREMINNNTTLRTERLIGCKQPIPKWLSFVVGGATVSYVREVSEVDLVNRTLVMKSMNLTMNNLLLVKETVIYKPDDELPHNKTVFHQSAEITAFASLSRLCDKLEDWSVERFGQNAKSGRLAFENVLNKLTLKWEENGIFENNKILQEVKNLSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1B3</accession>
    <accession>A0A1D8PMK7</accession>
    <accession>Q5A1H1</accession>
    <name>PGA41_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell wall protein PGA41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Predicted GPI-anchored protein 41</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PGA41</name>
        <name type="ordered locus">CAALFM_C406310CA</name>
        <name type="ORF">CaO19.10424</name>
        <name type="ORF">CaO19.2906</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Antimicrob. Agents Chemother." volume="57" first="873" last="886">
            <title>Milbemycins: more than efflux inhibitors for fungal pathogens.</title>
            <authorList>
                <person name="Silva L.V."/>
                <person name="Sanguinetti M."/>
                <person name="Vandeputte P."/>
                <person name="Torelli R."/>
                <person name="Rochat B."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="23208712"/>
            <dbReference type="DOI" id="10.1128/AAC.02040-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715561.2">
        <property type="nucleotide sequence ID" value="XM_710468.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1B3"/>
    <dbReference type="STRING" id="237561.Q5A1B3"/>
    <dbReference type="GlyCosmos" id="Q5A1B3">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_06310C_A-T">
        <property type="protein sequence ID" value="C4_06310C_A-T-p1"/>
        <property type="gene ID" value="C4_06310C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642800"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406310CA"/>
    <dbReference type="CGD" id="CAL0000197357">
        <property type="gene designation" value="PGA41"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06310C_A"/>
    <dbReference type="HOGENOM" id="CLU_940073_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A1B3"/>
    <dbReference type="OrthoDB" id="4025955at2759"/>
    <dbReference type="PRO" id="PR:Q5A1B3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424739" description="Probable cell wall protein PGA41">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424740" description="Removed in mature form" evidence="2">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23208712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="296" mass="30408" checksum="BBA31C2B217B0D49" modified="2017-03-15" version="2" precursor="true">MKFTIVLFTLISVTVAAAATTTTTAAANRIQNKAYAYYYCNSYCTQAVNDENSCGYYDTDVSNQEYYACLCTKSSYYNNLRSCDCFTKVVYYYSTSICSRANVGTYVGGRTSTTWGVSATKYRSSTSTSSLTRKSSSIGASPSIAIASSTKESSSTESSSSLEQSSSAGQSSSTEQSPSTEVSSSSSIEESSSNQDISSTDSITTISSDSSTGNTDSPTQGGGGNSGNNGSNGDGGNDASGGGGVVNENEQASSPPSSQSSTNSNQPNSSQTAPGAANYLSSVSVGTLMILVLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1E8</accession>
    <name>Q5A1E8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">SDH12</name>
        <name evidence="21" type="ordered locus">CAALFM_C406610CA</name>
        <name evidence="20" type="ordered locus">orf19.10389</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion inner membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="16"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715528.1">
        <property type="nucleotide sequence ID" value="XM_710435.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1E8"/>
    <dbReference type="SMR" id="Q5A1E8"/>
    <dbReference type="FunCoup" id="Q5A1E8">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1E8"/>
    <dbReference type="GeneID" id="3642775"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406610CA"/>
    <dbReference type="CGD" id="CAL0000176470">
        <property type="gene designation" value="SDH12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06610C_A"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="InParanoid" id="Q5A1E8"/>
    <dbReference type="OMA" id="NRCAETI"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000026">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 16" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="18">
        <location>
            <begin position="56"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="19">
        <location>
            <begin position="506"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="450"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0000176470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AOW29384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="641" mass="70176" checksum="894AE33A9B3062F5" modified="2005-04-26" version="1">MLTSLRNQVKSSAVTKRLLSSSSVRSQVIGSNVKGQDFNAAKYMSQKYHVVDHEYDCVVVGAGGAGLRAAFGLVSEGFKTACVSKLFPTRSHTVAAQGGINAALGNMHADDWHWHFYDTVKGSDWLGDQDAIHYMTKEAPASIYELEHYGVPFSRNDEGRIYQRAFGGQSKEFGKGGQAYRTCAVADRTGHALLHSLYGQSLRHDCHFFIEFFAMDLMMKDGACIGIIAYNEEDGTLHRFFANRTIMATGGYGRAYFSCTSAHTCTGDGYAMVSRAGLPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPSAKDLASRDVVSRAITMEINEGRGVGPEKDHMYLQLSHIPAPVLKERLPGISETAHIFAGVDVTKEPIPILPTVHYNMGGIPTNWKGEVLKKSADGNDEVVPGLLACGEAACASVHGANRLGANSLLDLVVFGRAVAHTIRDNLQPGTPIPDHAKDIGYESIANLDKLRNANGSKPTADIRLEMQKTMQKGCAVFRTQETLDQCVEHIGEVDKSFEDVKTTDRSMIWNSDLVETLELQNLLTCATQTAASAAARTESRGAHSRDDFPDRDDVNWRKHTLSYQETVGGPVRLDYRDVVKTTLDENDCKPVPPAKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1M6</accession>
    <name>Q5A1M6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ccw14p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">CCW14</name>
        <name evidence="4" type="ordered locus">CAALFM_C501010WA</name>
        <name evidence="3" type="ordered locus">orf19.9525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715731.1">
        <property type="nucleotide sequence ID" value="XM_710638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1M6"/>
    <dbReference type="STRING" id="237561.Q5A1M6"/>
    <dbReference type="GeneID" id="3642650"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501010WA"/>
    <dbReference type="CGD" id="CAL0000185411">
        <property type="gene designation" value="CCW14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01010W_A"/>
    <dbReference type="eggNOG" id="ENOG502S6U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067848_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A1M6"/>
    <dbReference type="OMA" id="CICINED"/>
    <dbReference type="OrthoDB" id="3998031at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971206" evidence="2">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000185411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="271" mass="30625" checksum="E88ACAB9468E08CC" modified="2005-04-26" version="1">MLVLVIALVFLKSILATPPACFLSCINEIAHDCPEDAVNLTCICINEDLIIGCLVDICPFGTFISARDHYIGTCLEHGRPSITNPVPPPAIWPPEPKVSSISNTTMRTEFTSSIMQVTQTVEFPARVTITPIPSDIPKPEIVDESEDEFYNPNEPCEWEETDSLDENGAFIVIRRPVNVPKRYRDPSNVGNIRRVIITRPVNYYSNQQASDNPKPHKVQHVKRIKKFPKKVSKNANESKMSPSTLNQKIKPNRNNLKKLHKKKFKVNRKSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1U8</accession>
    <accession>A0A1D8PN33</accession>
    <accession>Q5A1P1</accession>
    <name>ERFD_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ERF4</name>
        <name type="synonym">SHR5</name>
        <name type="ordered locus">CAALFM_C501170WA</name>
        <name type="ORF">CaO19.1955</name>
        <name type="ORF">CaO19.9510</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330955.1">
        <property type="nucleotide sequence ID" value="XM_019475410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1U8"/>
    <dbReference type="SMR" id="Q5A1U8"/>
    <dbReference type="FunCoup" id="Q5A1U8">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1U8"/>
    <dbReference type="EnsemblFungi" id="C5_01170W_A-T">
        <property type="protein sequence ID" value="C5_01170W_A-T-p1"/>
        <property type="gene ID" value="C5_01170W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642662"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501170WA"/>
    <dbReference type="CGD" id="CAL0000178317">
        <property type="gene designation" value="orf19.9510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01170W_A"/>
    <dbReference type="eggNOG" id="ENOG502S30T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087349_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A1U8"/>
    <dbReference type="OMA" id="CITHFPN"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="PRO" id="PR:Q5A1U8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000213982" description="Ras modification protein ERF4">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P41912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="218" mass="24666" checksum="3AD6A1566D1DD8F8" modified="2017-03-15" version="3">MNETKTDSTVNPDQSSQELVFFNYHEYLVPGSDDTSLVINHFPNIHTDLSSSTFKETRIIRIPRVYHTVQFPDLIPQFSCYYPGSEPGAITSTQLMSGSFDDNSFNESSSIPSLENIISRSEFENIVSLVNESLAVAFNPMSKRMLLENLLDLLSGGLFLSLLNFLGIYSFTKRKLMELESQIDSINQINEKKGVDFKIISPRVTGYLSLDFQITKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1Y2</accession>
    <name>Q5A1Y2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">RIB1</name>
        <name evidence="12" type="ordered locus">CAALFM_CR02990CA</name>
        <name evidence="11" type="ordered locus">orf19.10380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715792.1">
        <property type="nucleotide sequence ID" value="XM_710699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1Y2"/>
    <dbReference type="SMR" id="Q5A1Y2"/>
    <dbReference type="FunCoup" id="Q5A1Y2">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1Y2"/>
    <dbReference type="GeneID" id="3642607"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02990CA"/>
    <dbReference type="CGD" id="CAL0000174579">
        <property type="gene designation" value="RIB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02990C_A"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="InParanoid" id="Q5A1Y2"/>
    <dbReference type="OMA" id="RLPNVEC"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019238">
        <property type="term" value="F:cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="171"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000174579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="342" mass="37643" checksum="D59723944ACF2153" modified="2005-04-26" version="1">MTSIKHPKPSTVSASSHGIRTPPTVSTSPDLDVNRIPMVTPKPSTNNLPVTTPQPPPAITQSMRNKSGLPDSLPHVKCLARARIPTTQGPDIFLHLYENNIDNKEHLAIVFGEDIRSRSLFKHYPGETQQDRMTRGAYIGRLTPGRTIADSDGTNELKFDKDGNLIIDSLTYTDPTLVRIHSECYTGETAWSARCDCGEQFDEAGRIMGEAGHGCMVYLRQEGRGIGLGEKLKAYNLQDLGADTVEANLILRHPADGRNFSLATAILVDLGLVEIKLLTNNPDKIVAVEGKHQEVKVLERVPMVPLSWGKDGKNGIKSKEIEGYLSTKIERMGHLLEKPIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A207</accession>
    <name>Q5A207_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_CR02780WA</name>
        <name evidence="6" type="ordered locus">orf19.10354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715767.1">
        <property type="nucleotide sequence ID" value="XM_710674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A207"/>
    <dbReference type="SMR" id="Q5A207"/>
    <dbReference type="STRING" id="237561.Q5A207"/>
    <dbReference type="GeneID" id="3642582"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02780WA"/>
    <dbReference type="CGD" id="CAL0000180005">
        <property type="gene designation" value="orf19.10354"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02780W_A"/>
    <dbReference type="eggNOG" id="ENOG502RXIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084253_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A207"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000180005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="163" mass="17865" checksum="7727A46F81294321" modified="2005-04-26" version="1">MSIAQEFEKANTHYSSNFTKRDLPLPPARKVAVVICMDARIDPAASLGLTEGDAHVIRNAGGRASDALRSVIISQRLLGTREIVVVHHTDCGMLTFSDNDLRGIVAKETGHNVDHFAFLPFGDLEKSVKDDVEFFKRNPLVLDVPVTGYIYDVKSGAINKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A2A5</accession>
    <name>Q5A2A5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">GRS1</name>
        <name evidence="17" type="ordered locus">CAALFM_C105290WA</name>
        <name evidence="16" type="ordered locus">orf19.8067</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715872.1">
        <property type="nucleotide sequence ID" value="XM_710779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A2A5"/>
    <dbReference type="SMR" id="Q5A2A5"/>
    <dbReference type="FunCoup" id="Q5A2A5">
        <property type="interactions" value="1166"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A2A5"/>
    <dbReference type="GeneID" id="3642474"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105290WA"/>
    <dbReference type="CGD" id="CAL0000176302">
        <property type="gene designation" value="GRS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05290W_A"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A2A5"/>
    <dbReference type="OMA" id="MEMQYFV"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="171"/>
            <end position="520"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000176302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW26199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="652" mass="73714" checksum="90AF08BEBC9D47E8" modified="2005-04-26" version="1">MSASRTNIPFSRDSLEQTLKRRFFFAPSFEIYGGVAGLFDFGPPGCAFQNNVIDAWRKHFILEEDMLEVEATMLTPHDVLKTSGHVDRFSDWMCKDLKTGEIFRADHLVEEVLESRLKGDKLARGVKIVEEEDEDKKKRKKKVKEIKNVKLEDEVVKEYESILAQIDGFSGPQLGELIVKYDITNPSTGGKLEPPVEFNLMFDTAIGPSGNLKGYLRPETAQGQFLNFNKLLEFNNDKMPFASASIGKSFRNEIAPRAGLLRVREFLMAEIEHYVDPESKSHPKFEDVKDIKLKFLPKNVQESGSTELIEESIGKAVSSGMVDNETLGYFIARIYLFLVKIGVDTNRLRFRQHMSNEMAHYASDCWDAELETSYGWIECVGCADRSAYDLSVHSARTGEKLVARQTLAEPRTVENFEIEIAKKKFGPKFRKDAGTVEKWLTSRTQCELEELGKELSEKGKIVVQIKGVEGDVELDGDLIKIDKVKRTEHVREFVPNVIEPSFGIGRILYSIFEHQFWCRPDDADRGVLSLPPIVAPTKVLLVPLSNNSELQPIVKKVSQALRKEKIPFKVDDSSASIGKRYARNDELGTPFGITIDFDSVKDDSVTLRERDSTKQVRGSIQEIVEAIKDITYNDGTWEEGTAKLKPFEGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A355</accession>
    <name>Q5A355_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_CR08420WA</name>
        <name evidence="9" type="ordered locus">orf19.13766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716247.1">
        <property type="nucleotide sequence ID" value="XM_711154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A355"/>
    <dbReference type="STRING" id="237561.Q5A355"/>
    <dbReference type="GeneID" id="3642117"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08420WA"/>
    <dbReference type="CGD" id="CAL0000183386">
        <property type="gene designation" value="orf19.13766"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08420W_A"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_5_1"/>
    <dbReference type="InParanoid" id="Q5A355"/>
    <dbReference type="OMA" id="HTCEVNL"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000245">
        <property type="entry name" value="DnaJ domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000183386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="539" mass="60296" checksum="D06BDE903D6590FC" modified="2005-04-26" version="1">MVRETFFYDILSVSTSATTEEISKSFKKLALKCHPDKTNRDPELTEKFKQITRAYEVLRDPKQRDIYDKYGEAGIDGTVQESTSNTTASNTRNHRRTHSFATDIFSQVFHDINNMFATHNAMFEGPQMSGGFPGFSSNQHMQKHVEPLGEPLENTLIHGEDIFHTCEVNLADMVYGKVIKLSLPKNMKCVQCNGYGGVNPKTCRVCLGSGKVMITYYNQFSRFQQSGSCAACHGTGVFIRDADRCVYCNMGYLESTKILKVVVPPGANTGDRIIIKGEADEGRNIIPGDVVIKLKQRQHPYLVRKYNDLYMDHTIDLKTALLGGEITIPDFLKEDQSLKIYINVHGYKSLNNEKVHAGEVVGTIRSGEPKQVKGLGVPKNNRIRNGIIVQDSSQQNVSKQTMFDLNKYSRGNLFINFHVKLPRIENFSENDLVQLNHIFNNVPNSNDMNNDHGNIIESNLANLPGSRANPIVLEATPSVSESPSRESNGSIKLDFSNIGINDGTNTTGRDNSSHPYFEEAQNKRRRFESDLGCGIANPI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-10-29" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4E3</accession>
    <accession>A0A1D8PKE6</accession>
    <name>OCH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Outer chain elongation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">OCH1</name>
        <name type="ordered locus">CAALFM_C306090CA</name>
        <name type="ORF">CaO19.7391</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="J. Biol. Chem." volume="281" first="90" last="98">
            <title>Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans.</title>
            <authorList>
                <person name="Bates S."/>
                <person name="Hughes H.B."/>
                <person name="Munro C.A."/>
                <person name="Thomas W.P."/>
                <person name="MacCallum D.M."/>
                <person name="Bertram G."/>
                <person name="Atrih A."/>
                <person name="Ferguson M.A."/>
                <person name="Brown A.J."/>
                <person name="Odds F.C."/>
                <person name="Gow N.A."/>
            </authorList>
            <dbReference type="PubMed" id="16263704"/>
            <dbReference type="DOI" id="10.1074/jbc.M510360200"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="J. Clin. Invest." volume="116" first="1642" last="1650">
            <title>Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.</title>
            <authorList>
                <person name="Netea M.G."/>
                <person name="Gow N.A."/>
                <person name="Munro C.A."/>
                <person name="Bates S."/>
                <person name="Collins C."/>
                <person name="Ferwerda G."/>
                <person name="Hobson R.P."/>
                <person name="Bertram G."/>
                <person name="Hughes H.B."/>
                <person name="Jansen T."/>
                <person name="Jacobs L."/>
                <person name="Buurman E.T."/>
                <person name="Gijzen K."/>
                <person name="Williams D.L."/>
                <person name="Torensma R."/>
                <person name="McKinnon A."/>
                <person name="MacCallum D.M."/>
                <person name="Odds F.C."/>
                <person name="Van der Meer J.W."/>
                <person name="Brown A.J."/>
                <person name="Kullberg B.J."/>
            </authorList>
            <dbReference type="PubMed" id="16710478"/>
            <dbReference type="DOI" id="10.1172/JCI27114"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="J. Infect. Dis." volume="199" first="1087" last="1096">
            <title>Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="van de Veerdonk F.L."/>
                <person name="Joosten L.A."/>
                <person name="Devesa I."/>
                <person name="Mora-Montes H.M."/>
                <person name="Kanneganti T.D."/>
                <person name="Dinarello C.A."/>
                <person name="van der Meer J.W."/>
                <person name="Gow N.A."/>
                <person name="Kullberg B.J."/>
                <person name="Netea M.G."/>
            </authorList>
            <dbReference type="PubMed" id="19222370"/>
            <dbReference type="DOI" id="10.1086/597274"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="4364" last="4378">
            <title>Yeast-to-hyphal transition triggers formin-dependent Golgi localization to the growing tip in Candida albicans.</title>
            <authorList>
                <person name="Rida P.C."/>
                <person name="Nishikawa A."/>
                <person name="Won G.Y."/>
                <person name="Dean N."/>
            </authorList>
            <dbReference type="PubMed" id="16855023"/>
            <dbReference type="DOI" id="10.1091/mbc.E06-02-0143"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Infect. Immun." volume="76" first="4509" last="4517">
            <title>Beta-1,2 oligomannose adhesin epitopes are widely distributed over the different families of Candida albicans cell wall mannoproteins and are associated through both N- and O-glycosylation processes.</title>
            <authorList>
                <person name="Fradin C."/>
                <person name="Slomianny M.C."/>
                <person name="Mille C."/>
                <person name="Masset A."/>
                <person name="Robert R."/>
                <person name="Sendid B."/>
                <person name="Ernst J.F."/>
                <person name="Michalski J.C."/>
                <person name="Poulain D."/>
            </authorList>
            <dbReference type="PubMed" id="18644880"/>
            <dbReference type="DOI" id="10.1128/IAI.00368-08"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="Fungal Genet. Biol." volume="56" first="107" last="115">
            <title>Reporters for the analysis of N-glycosylation in Candida albicans.</title>
            <authorList>
                <person name="Shahana S."/>
                <person name="Mora-Montes H.M."/>
                <person name="Castillo L."/>
                <person name="Bohovych I."/>
                <person name="Sheth C.C."/>
                <person name="Odds F.C."/>
                <person name="Gow N.A."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="23608318"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2013.03.009"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Med. Mycol." volume="49" first="513" last="524">
            <title>Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling.</title>
            <authorList>
                <person name="Sheth C.C."/>
                <person name="Hall R."/>
                <person name="Lewis L."/>
                <person name="Brown A.J."/>
                <person name="Odds F.C."/>
                <person name="Erwig L.P."/>
                <person name="Gow N.A."/>
            </authorList>
            <dbReference type="PubMed" id="21254968"/>
            <dbReference type="DOI" id="10.3109/13693786.2010.551425"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3 4 6 7 8 9">Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates (By similarity). Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. N-glycan outer chain epitopes play a crucial role in the host-fungal interaction, virulence, and host immune response such as interleukin synthesis or phagocytosis by neutrophils.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1-&gt;6)-D-mannosyl-D-mannose linkage.</text>
            <dbReference type="EC" id="2.4.1.232"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Is recycled between the trans-Golgi network and a late compartment of the endoplasmic reticulum.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The conserved DXD motif is involved in enzyme activity.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4 6 7 8 9">Results in a temperature-sensitive growth defect, cellular aggregation, loss of outer chain elongation of N-glycans, hypersensitivity to a range of cell wall perturbing agents, as well as to constitutively activated cell wall integrity pathway. Finally, leads to attenuated virulence in a mouse model of systemic infection and affects inflammatory response and the efficiency of neutrophil phagocytosis by the host.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.232" evidence="1"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716632.1">
        <property type="nucleotide sequence ID" value="XM_711539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4E3"/>
    <dbReference type="BioGRID" id="1224845">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A4E3">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4E3"/>
    <dbReference type="EnsemblFungi" id="C3_06090C_A-T">
        <property type="protein sequence ID" value="C3_06090C_A-T-p1"/>
        <property type="gene ID" value="C3_06090C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641751"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306090CA"/>
    <dbReference type="CGD" id="CAL0000174808">
        <property type="gene designation" value="OCH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06090C_A"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_5_0_1"/>
    <dbReference type="InParanoid" id="Q5A4E3"/>
    <dbReference type="OMA" id="DWADWYS"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033164">
        <property type="term" value="F:initiation-specific glycolipid 1,6-alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000430618" description="Initiation-specific alpha-1,6-mannosyltransferase">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DXD motif" evidence="1">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P31755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16263704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16710478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16855023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="18644880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="19222370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="21254968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="23608318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="16263704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <sequence length="385" mass="44828" checksum="BD0616E650AB1700" modified="2005-04-26" version="1">MLQLREPQMVHKHLKLAVLGIVVIFTTYFIISSLSSPTSTHKTEYNSPKLQLAKELELNSNWKELGLNFQPNKKYSLPDESTLRQQLSYQFPYDESKPFPKNIWQTWKVGIDEKSFPKRYLKYQQTWEDKNPDYKHYVVPDKQCDLLIEQLYSQVPDVAKAYRIMPKSILKADFFRYLILFARGGVYTDIDTVGLKPVDEWISNSEMILEKKNRSGLVVGIEADPDRPDWADWYARRIQFCQWTIQSKRGHPMLRELIAKITDITLTRHKKGQLKKVLGKNEGGDIMNWTGPGIFTDTVFEYMNNILQSPEVFKNKKKWATIIDWKLFTGMEQPIAIDDVLVLPITSFSPDVNQMGAKDSHDPMAYAKHMFSGSWKDDGMPEMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7N9</accession>
    <name>Q5A7N9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mn(2+) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C300390WA</name>
        <name evidence="8" type="ordered locus">orf19.12883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717800.1">
        <property type="nucleotide sequence ID" value="XM_712707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7N9"/>
    <dbReference type="SMR" id="Q5A7N9"/>
    <dbReference type="FunCoup" id="Q5A7N9">
        <property type="interactions" value="310"/>
    </dbReference>
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        <property type="gene designation" value="orf19.12883"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C3_00390W_A"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000180828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="270" mass="29338" checksum="5B5DE2ECB1120C87" modified="2005-04-26" version="1">MTLVLIALPLVMFVATFVAGILPLKLTVAQHHLKYLSFLSMGILIGTAMMIILPEGIETISHETTDVASYVGFPILLGFLTMYILDCMFSTNVKAQESSVVESVVGSPITLGLIFHGIIDGISLGSSLASGEVMTLIIFAAIIIHKIPTSFSLSTILLQEGTSDSKLYWHILLFALSSPSACWFTFVLIKLVNAKSNLVIGVLFLYSAGTFLFVVNHVMHEFSSNDFYTLPTSVESDTTTVESHSKISRNELILSLIGILIPTLLSFAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7Q7</accession>
    <name>Q5A7Q7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ist1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">IST1</name>
        <name evidence="4" type="ordered locus">CAALFM_C300540CA</name>
        <name evidence="3" type="ordered locus">orf19.12864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717781.1">
        <property type="nucleotide sequence ID" value="XM_712688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7Q7"/>
    <dbReference type="SMR" id="Q5A7Q7"/>
    <dbReference type="FunCoup" id="Q5A7Q7">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5A7Q7"/>
    <dbReference type="GeneID" id="3640587"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300540CA"/>
    <dbReference type="CGD" id="CAL0000189621">
        <property type="gene designation" value="IST1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00540C_A"/>
    <dbReference type="eggNOG" id="KOG2027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037652_2_0_1"/>
    <dbReference type="InParanoid" id="Q5A7Q7"/>
    <dbReference type="OMA" id="HEFVEMS"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099638">
        <property type="term" value="P:endosome to plasma membrane protein transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000189621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="253" mass="28387" checksum="80E907D511473FF2" modified="2005-04-26" version="1">MARPGSVPLHLNPLRLKTALKMAISKLRFIQEKKTAITKQQRRQLSELLSQGKESSSKIRVENIIRDDIYIELLEILELYCELLLARLPILLKRTTVEKNLQEAVNSIIYSANHTELKELVTIKDILVYKFGGPEFAQPILDNKNGEEVPEKVVKRCDIEPPSETLVDLYLCEIARAYNVPYSGLKEEEATNASGDNSDDDNDDGGQKEFGLAEPLGGVAVKPVFKNHDPKQQEESDFDALKARFAALKGTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A892</accession>
    <name>Q5A892_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_CR01170WA</name>
        <name evidence="9" type="ordered locus">orf19.10747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717928.1">
        <property type="nucleotide sequence ID" value="XM_712835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A892"/>
    <dbReference type="SMR" id="Q5A892"/>
    <dbReference type="FunCoup" id="Q5A892">
        <property type="interactions" value="1273"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A892"/>
    <dbReference type="GeneID" id="3640429"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01170WA"/>
    <dbReference type="CGD" id="CAL0000196972">
        <property type="gene designation" value="orf19.10747"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01170W_A"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A892"/>
    <dbReference type="OMA" id="FFTIHAQ"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1342"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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            <begin position="98"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="205"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="773"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1299"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="149"/>
            <end position="161"/>
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            <begin position="162"/>
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            <begin position="217"/>
            <end position="233"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="710"/>
            <end position="722"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="755"/>
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    </feature>
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        <location>
            <begin position="759"/>
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            <begin position="1276"/>
            <end position="1294"/>
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    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000196972"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1711" mass="193264" checksum="A0A623334ECC9E47" modified="2005-04-26" version="1">MTDKEKKVNNSNPQEDVSRFSDDDSMSIQDADISDSEHDLLIRLSQQAQNRRASQNQYHNDINVIGDDSHNDTTASLDLEVVSNEHDIEDHLDDEIIEEDDDDDDNSDNDDNSHDHSDDFEDPDSMSMMETADFLRQLMQARRNRTTEIRNSNSDSAGQSLNEDDDEMDNDEHDNINDDDDNDGDGNEDDEEVEEEEDEDEDDPRAEFLRAIGALTGGNRNSSNGDTSSSGNGFVDVMQRLMGGGVIFDGGSARDSGEIDALVNNLSQREDTYIVLESMNELSERLLMMNGLTAERLIPANKLARSLIEIMEDPKLEEELELHLVACRCLYNFLEVNQDFIHDALNNNAIPALCNKLLEIKYIDLTEQALQTLEMISRDPISHNSIISNNGLTACLQYLDFLTIHAQRKCLTIVANSCSNISIGNFPKVKEAFNGIAEVVRNHNDKVVVENAWLTISRIVMCFKNKPDLLNELFADKELLFKELTKVILVSCNKSSNTSSESNQVTLNHGSNLSLIKSLIILVSVSVDVSRILISECEIGSIIVKSLNKYAKQNQEIDPLKTHSDSISIEALMSAPKDLISQFLSLIGYLLPITYSTSDALYLRPNYEQDQERQNINQTRIELCTQLIPNEYWKFVNDIWSLLILSFQATMDFEIRRKGFVNLYRIICSNESDFSLIKDVDFIAGLLANVVTQYQSIVIKEFASVESNDDDMVSTDVEENEELGQASTSQEDEDDYDDEDEDDEVVDEDEDEEFSILDSRGTSSIQSSTSSLPEDVNKLNSLMLLLSSLKIIKVLLEKAPFTIIGLFEKEGLINDVLRLLKTLSDKADLNEKDPRASINSMMSAYSNKFIDSEFTKEYEYKLTSRVIYSNIVSIATDINSLYQQSKNEGLQNISENMKVLQEVKTTLSNHKNIKSFSYNQWLELWNNLKLAFCGSSSPVSSFELISSGAIESLTKLFSTDFGLESSDCYKAFTEAFWKDDSATFLVQKLQEALTRSESFDIVSATSSTNNQSSFARDQNQAAIMANQIKLKLIAEDENSDQSKLPGNMQNMILSVHAIATFKSVFAFLKQRFKFFEELGGSLNRSFNNEDSERKQDLNIEFLINGEVIPNETTIYGVIYRSLQETPDEVVNSSKIWSKVHNITYRKVSSEVSKEAPFTNFNLHYNTDRELSLYDDTTINILKLLKILFRMNNNFSNGGGHNVATKEFTNWKLTVKLNRQLEEPLVVASGTLPGWSIHLTKQFPFIFPFETRIFFLQSTSFGYSRLIHQWQLRTNQGGDDNVGSTSTNQGNNQRMQLGRPTRHKVRISRKMMLQSAVKVLGMYGSTPGILEIEYFDEEGSGLGPTLEFYSTVSKEFSKKKLRLWRDEEPRQASDVDVDVDESYVVNKYGLFPKPMDKTQLSSENGRKVLYFFSSLGKFIARALLDSRIIDFNFNPVFLSLIQLLNKTNGINSTSRTNTSKLSKKMATISNLRLVDPTLADSLQHLNKYIELFESNSDIHNVTVDGARVEDLALFFELPGNPDYELIPNGSDTLVTADNLELYINKVIEATLFSGILTQTKAFMDGFSKVFPINSLIIFSSRELVELFGNAEEDWSMDTLTSSIVANHGYTKESEAIKSLIDILMNFSIEEKREFLQFLTGAPKLPIGGFKALRPELTVVRKHAEDGLKDDDYLPSVMTCANYLKLPNYSSKEMMKEKLIQAMKEGAGAFLLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB49</accession>
    <accession>A0A1D8PDZ9</accession>
    <accession>Q5AAW0</accession>
    <name>Y6200_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable pathogenesis-related protein CaO19.6200</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C107040CA</name>
        <name type="ORF">CaO19.13580</name>
        <name type="ORF">CaO19.6200</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Eukaryot. Cell" volume="1" first="514" last="525">
            <title>Large-scale identification of putative exported proteins in Candida albicans by genetic selection.</title>
            <authorList>
                <person name="Monteoliva L."/>
                <person name="Matas M.L."/>
                <person name="Gil C."/>
                <person name="Nombela C."/>
                <person name="Pla J."/>
            </authorList>
            <dbReference type="PubMed" id="12456000"/>
            <dbReference type="DOI" id="10.1128/EC.1.4.514-525.2002"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002592" last="E1002592">
            <title>The novel Candida albicans transporter Dur31 is a multi-stage pathogenicity factor.</title>
            <authorList>
                <person name="Mayer F.L."/>
                <person name="Wilson D."/>
                <person name="Jacobsen I.D."/>
                <person name="Miramon P."/>
                <person name="Grosse K."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="22438810"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002592"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Mol. Microbiol." volume="87" first="132" last="151">
            <title>A family of secreted pathogenesis-related proteins in Candida albicans.</title>
            <authorList>
                <person name="Rohm M."/>
                <person name="Lindemann E."/>
                <person name="Hiller E."/>
                <person name="Ermert D."/>
                <person name="Lemuth K."/>
                <person name="Trkulja D."/>
                <person name="Sogukpinar O."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
                <person name="Urban C.F."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="23136884"/>
            <dbReference type="DOI" id="10.1111/mmi.12087"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted protein that acts as a virulence factor during infections.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Induced in hyphae and up-regulated during oral infection. Expression is higher in white cells.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">reduces capacity to damage oral epithelial cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718791.1">
        <property type="nucleotide sequence ID" value="XM_713698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AB49"/>
    <dbReference type="SMR" id="Q5AB49"/>
    <dbReference type="FunCoup" id="Q5AB49">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_07040C_A-T">
        <property type="protein sequence ID" value="C1_07040C_A-T-p1"/>
        <property type="gene ID" value="C1_07040C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639533"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107040CA"/>
    <dbReference type="CGD" id="CAL0000178383">
        <property type="gene designation" value="orf19.13580"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07040C_A"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AB49"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="PRO" id="PR:Q5AB49"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000429963" description="Probable pathogenesis-related protein CaO19.6200">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SCP">
        <location>
            <begin position="187"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22438810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23136884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="317" mass="34075" checksum="651C0F982A237AD8" modified="2005-04-26" version="1" precursor="true">MKFLQSFPVILAVFSFAANLVSSKLVYEYETKYVTVEIVTIVSGETTYTTERLETNGPTSTTTTIVIPSSKPSSPESKPKSDSQPMFQSPSPVQITPSTTSINNAPSPTKPETTVTASPAVIAHTSVFVVTPNSAPTTSSSPPNIVQQVKAAITPSAPKPQPQPQPQENNSGTNDDSQLSSFSRQILEAHNIKRASHGVNPLTWSNELYNYANKVASSYDCSGNLRHTSGPYGENLALGYSSGANAVSAWYSEGFNFGGAGKLNHFTQVVWKSTTQLGCAYKDCRAKGWGLYIICNYQKPGNIIGQELANILPLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB86</accession>
    <name>Q5AB86_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LEU4</name>
        <name evidence="12" type="ordered locus">CAALFM_C100170WA</name>
        <name evidence="11" type="ordered locus">orf19.13505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719048.1">
        <property type="nucleotide sequence ID" value="XM_713955.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AB86"/>
    <dbReference type="SMR" id="Q5AB86"/>
    <dbReference type="FunCoup" id="Q5AB86">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AB86"/>
    <dbReference type="GeneID" id="3639339"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100170WA"/>
    <dbReference type="CGD" id="CAL0000186267">
        <property type="gene designation" value="LEU4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00170W_A"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AB86"/>
    <dbReference type="OMA" id="EYCNQME"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF2">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000186267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW25719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="579" mass="64210" checksum="B23E1525B812B881" modified="2005-04-26" version="1">MQKVFQRWVSRIPPVKLQYKNMLRDPSKKYSPPKQINLPNRTWPTKVITKAPRWLSTDLRDGNQSLPDPMSVPEKKEYFHKLIDIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVTIQVLTQSREPLIRRTVESVKGAKRATIHTYLATSDVFREVVFGMSKQDAIDKAIETTKLVRSLTKDDPNMQDTEWNLEFSPECFSDTPVEFAVEICEAVKKAWEPTVENPMIFNLPATVEVAGPNVYADQIEYFCQNITEREKIIVSTHTHNDRGCGVAATELGMLAGADRVEGCVFGNGERTGNVDLVTVALNLYTQGIAPNLDFSDIESIIEVSERCNKIPVPARSPYGGSLVVCAFSGSHQDAIKKGFAKQKGDKWAIPYLPLDPKDIGRTYEAVIRVNSQSGKGGAAWVILRSLGLDLPRHLQVAFSGLVQNTADSLGRELKVDEIVNLFNEQYLVSAPLSIQDFEITKNKNDEREIVAQLNDGITIKGQGNGPISAFIDAISNKFGVLFEVVNYQEHSLGGGSSSKAATYIELSYVNANGEKVTRWGCGINHDVSQASIEAILSVVNSLIKKNELTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB98</accession>
    <name>Q5AB98_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cdc13p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">CDC13</name>
        <name evidence="3" type="ordered locus">CAALFM_C100360WA</name>
        <name evidence="2" type="ordered locus">orf19.13493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719034.1">
        <property type="nucleotide sequence ID" value="XM_713941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AB98"/>
    <dbReference type="STRING" id="237561.Q5AB98"/>
    <dbReference type="GeneID" id="3639293"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100360WA"/>
    <dbReference type="CGD" id="CAL0000201142">
        <property type="gene designation" value="CDC13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00360W_A"/>
    <dbReference type="eggNOG" id="ENOG502RQC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685107_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AB98"/>
    <dbReference type="OrthoDB" id="4024719at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000805">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="447" mass="51370" checksum="177B3BEECB7578AE" modified="2005-04-26" version="1">MCFIRKTRKINKQNRARLQKFFFFINTCQLLSLQLHTQLQYEMARDLIKIEDFPEIMDGQKQGPRVGFCGLVVRFYPSRRDYIGMDVTDFTSHPRVCQNQEYYNGGLLLARNELLTIPVKIEALKRIQVSYPGIFGEQYNLAEEYYSASGVLDVHDKLLVVKMTLRTRLYQGFYEPYSYDQEIVDYEYLGNKDRLVVDDLFRNIVSRKEYFSKVSHLAPRLMPAKFLISTGHSSEVSDKVQHLNAISSVPDTKIKSPPHNSQYIHPPDPNTIRSSPTQNLVPDIEHGDFDFCNSSTVGSPEEEQVFTISELKQLDMTIDNKTYMVSCKIIGCFPDDWMYLSGKEMDPKSNTAKDPIIRDLEWIIADANVDERTVLNSENTLSVISPAQDILEFSNYGSVEDFFIGCSGYRKKSNSIFNIPTKLEVRKIEIPINSSTTTVVWSPVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABT9</accession>
    <name>Q5ABT9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylglyoxal reductase (NADPH-dependent)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C603240WA</name>
        <name evidence="4" type="ordered locus">orf19.13054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="4">
        <citation type="journal article" date="2019" name="Crystals" volume="9" first="0" last="0">
            <title>Crystal Structure of NADPH-Dependent Methylglyoxal Reductase Gre2 from Candida Albicans.</title>
            <authorList>
                <person name="Nguyen G.T."/>
                <person name="Kim S."/>
                <person name="Jin H."/>
                <person name="Cho D.H."/>
                <person name="Chun H.S."/>
                <person name="Kim W.K."/>
                <person name="Chang J.H."/>
            </authorList>
            <dbReference type="DOI" id="10.3390/cryst9090471"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 4-342 IN COMPLEX WITH NADPH</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719172.1">
        <property type="nucleotide sequence ID" value="XM_714079.2"/>
    </dbReference>
    <dbReference type="PDB" id="6KWS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A=4-342"/>
    </dbReference>
    <dbReference type="PDB" id="6KWT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.02 A"/>
        <property type="chains" value="A=4-342"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABT9"/>
    <dbReference type="SMR" id="Q5ABT9"/>
    <dbReference type="FunCoup" id="Q5ABT9">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABT9"/>
    <dbReference type="GeneID" id="3639181"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603240WA"/>
    <dbReference type="CGD" id="CAL0000179051">
        <property type="gene designation" value="orf19.13054"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03240W_A"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="Q5ABT9"/>
    <dbReference type="OMA" id="QGQMKEK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000179051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6KWS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6KWT"/>
        </source>
    </evidence>
    <sequence length="343" mass="37833" checksum="9FC7367CA9F17BD8" modified="2005-04-26" version="1">MSTPITVIVSGATGFIAQHVVKQLLAKNYQVIGTVRSTAKGDHLLKLFNNPQNLSYEIVEDVGTKGAFDKVLQKHGEAKVFLHLASPFHFNVTDVEKELLLPAVDGTKNVLQAIYNFGNNIEKVVITSSYAAISTASKEADKNAIITEKDWNEISWQDALLNPVNGYRGSKKFAEKAAWDFIKSNDNVKFSLSTINPSFVFGPQSFGSEIKQSLNTSSEIINSILKLKPNDSIPASKGGWVDVRDVAKAHIIAFENEDAKNQRILLNSGRFTSQSLVDIINDKFPDLKGKIPVDEPGSDKSVIAESLATIDDTKSRELLGFEYYNLEQSVYDTVEQIVNAHKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEN6</accession>
    <accession>A0A1D8PJG5</accession>
    <accession>Q5AF23</accession>
    <name>MED7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED7</name>
        <name type="ordered locus">CAALFM_C302440CA</name>
        <name type="ORF">CaO19.232</name>
        <name type="ORF">CaO19.7862</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719931.1">
        <property type="nucleotide sequence ID" value="XM_714838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEN6"/>
    <dbReference type="SMR" id="Q5AEN6"/>
    <dbReference type="BioGRID" id="1221377">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AEN6">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AEN6"/>
    <dbReference type="EnsemblFungi" id="C3_02440C_A-T">
        <property type="protein sequence ID" value="C3_02440C_A-T-p1"/>
        <property type="gene ID" value="C3_02440C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638344"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302440CA"/>
    <dbReference type="CGD" id="CAL0000180608">
        <property type="gene designation" value="MED7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02440C_A"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1906467_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AEN6"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="PRO" id="PR:Q5AEN6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
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    <keyword id="KW-0010">Activator</keyword>
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    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000303196" description="Mediator of RNA polymerase II transcription subunit 7">
        <location>
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        </location>
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        <location>
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        <location>
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            <end position="158"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="304" mass="34508" checksum="B237B6964D221793" modified="2005-04-26" version="1">MSTNNTTTNNEDLISSLYPPPPPYYKFFTKDNLQKLSTWQENNQTTTVSSEVKLEEENTDPDSNNSEENSIPPGELRFLIPPKQPEGPQYRGYGNIWLFEDKLPNLKDSQWEQLYNTSTSTFTSTSTSTANTNIITNTDTDINGNQEVDAGDSTGDENLTSETKIKELHKLMDSLLLNFLELIGILSIDPIKYDKKIHDINLILININHLLNTYRPHQSRESLIMLLKNQIDYKFLEIDQINKKCLDIKSKIKNLINERITVVSDGTTTNTTTTTKTTGLGDGDSIDEKEQLKQDIINRLLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AF43</accession>
    <name>Q5AF43_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C402400CA</name>
        <name evidence="3" type="ordered locus">orf19.10279</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW29009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="91988" checksum="298CA526F2E6A1D0" modified="2005-04-26" version="1">MSGFPMVPRFTNNTDDDDNSIHLKHNIGKANPLRSPTKRSRNNHNNEVFSYNNNNHNSDVSIDEKIAKIISNSKTSIRENGSDIIDNLPNGEYNQEKQQQEDEEFDDDDEEELDEFDTNKSYLKFLNGELQESINSNEDDNINGGGGLGGGRGGDEDYEDDEYILSDGDTFNEESLESNLNASGYEDEYLSDGDLEFDSDRFKEKNIFNDDDINDNLTKEHRHRYPRTRSNKLKFGSLSPSPSLSESDEIDLVNSQLSNPPHNNDMNWKQYIIISLVSFLMTILGYLLITGQISTILPNLLPISGSFDPIKMAKLDGKLHRLDQELKNSHQKQQETLFQLQSQIDQLNNKIISIIDNQQQQQQQQSSRNNEDKSTTTTNKKHEDIITLENNQIQISPEFHQFLYKFIDNYQNSYLDEKLQQLEKFNDLQQLQNYVEKLISMSMESIKQDIRIDIDNILDNLTTAPAHNNHTVIVNPKTNKLWINSILDLITQGTSSTSINYADYSTGARILGFLTSSSTSSSSSSHHSTPSILQKMIYGWWIYKSNFYQDEYNANHVLLDDDIVWKGGDQIGIRLSTNIIPTDIILECRDNNNNLPSTQTQGILLSIGFKPSTKNGFDKLSKIPLGLLNSHGQLSMTSSSSSSLQLPNQNENKYISKFKLIKQYHIKSSNGGGVDGIYHIRLPIRFINLQISGKDLYFKFDKIIKDNNDNINTIDNINININNIKVYGINEINAIKYQDKFQLLIDKFIDIEENDHNEQISTTTTTSKVIEINNNEKSSLMDFMTSRNSEKYQQQYDMNDDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AHB5</accession>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF2">
        <property type="entry name" value="PROTEIN DFG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="378"/>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Thorstenson Y.R."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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    </evidence>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Proteomics" volume="9" first="4770" last="4786">
            <title>Analysis of Candida albicans plasma membrane proteome.</title>
            <authorList>
                <person name="Cabezon V."/>
                <person name="Llama-Palacios A."/>
                <person name="Nombela C."/>
                <person name="Monteoliva L."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="19824013"/>
            <dbReference type="DOI" id="10.1002/pmic.200800988"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
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                <person name="De Groot P.W."/>
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                <person name="Klis F.M."/>
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            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19824013"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_717548.2"/>
    </dbReference>
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    <dbReference type="ESTHER" id="canal-q5ams7">
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    </dbReference>
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            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000183231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="264" mass="29712" checksum="91F7C20984493158" modified="2005-04-26" version="1">MQSGFSKNKQFYTYIPAVNSSSTKLLLFLHGLGSSQNFYYPIARKFPQFNVLLIDHEGAGQSKLLHHTNLSLQDLSENVVSVLQELSLNKLEITLIGHSMSGMLVSYMNLFTDLPIIENVLIAPVHPRKNLVDIMQKRIDSLQVSKSLIEFSNTIPEAATGSNCGDLQIAFIRQLIQGNSVDGYIANCQAINSGINYDFDYARINKPTLIIYGKQDQTSPWIGCVEEIYKNLPNAQLKELDVGHWIVIEDDKNVYDALEKFLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
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    <name>Q5APH8_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Fgr43p</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="ordered locus">CAALFM_C109270WA</name>
        <name evidence="2" type="ordered locus">orf19.12250</name>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718379.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5APH8"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000193193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="554" mass="62930" checksum="362E7824A5286481" modified="2005-04-26" version="1">MTDGIDYIDVCKTDVLGLDTLHHTSVIPSPIPTITFDCLPYTILSNICTYLHQEELINFSLISKTSYLPAIGTLYSKIIVTDNIDLTCSVKKAIKKYPRFCGTIISISNFGKLLNCLYHNQHLAGLLRSLSLDLNQESVNLISLLGIVRGLKLQSLVAPDIPFSYFSMRGRLNLDTIKILAVSAKDVGLTPLQFTELESLKIFYNETSRDKRNIRQLCKVLNEGNSLSKLRHLEFSESLQIKAPTFLNITNDDLDLDSIPAWAHFFDYFSNGKITRKLDLDSLAIEGWVGKKAKECMIRILSAVDLSKLNHLQLHVNEKYPKNEQHTSQRRLLDLITERTPALQSLAIKPTSDDLFIQHYTIIKTLKQNLVHQLKHLSLVFESPMAEQSLEVCSTICDCQHNLESLLILDRSTAVVDSELLHCCLSFDDYLLSLYDYGLIYEKKIVDLLFSDVLLTDFLKLDERFIINDYMLELARNATDKGLNDFLWNLLNYTFSSVTSNNFKLIVSLPALKLLNVLGISLVIRHDNGYLNDRVQGLYYNTNGRYSISCGSTY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2025-06-18" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q9P8E3</accession>
    <accession>A0A1D8PKY6</accession>
    <accession>Q59MJ6</accession>
    <name>SC61A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC61 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC61</name>
        <name type="ordered locus">CAALFM_C307810CA</name>
        <name type="ORF">CaO19.6176</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Fungal Genet. Biol." volume="41" first="941" last="953">
            <title>Analysis of heterologous expression of Candida albicans SEC61 gene reveals differences in Sec61p homologues related to species-specific functionality.</title>
            <authorList>
                <person name="de la Rosa J.M."/>
                <person name="Ruiz T."/>
                <person name="Fonzi W.A."/>
                <person name="Rodriguez L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ238713">
        <property type="protein sequence ID" value="CAB90210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710932.1">
        <property type="nucleotide sequence ID" value="XM_705840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9P8E3"/>
    <dbReference type="SMR" id="Q9P8E3"/>
    <dbReference type="FunCoup" id="Q9P8E3">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9P8E3"/>
    <dbReference type="EnsemblFungi" id="C3_07810C_A-T">
        <property type="protein sequence ID" value="C3_07810C_A-T-p1"/>
        <property type="gene ID" value="C3_07810C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647462"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307810CA"/>
    <dbReference type="CGD" id="CAL0000178942">
        <property type="gene designation" value="SEC61"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07810C_A"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="InParanoid" id="Q9P8E3"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000131781" description="Protein transport protein SEC61 subunit alpha">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="168"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="268"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="435"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAB90210." evidence="4" ref="1">
        <original>P</original>
        <variation>H</variation>
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15341916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="479" mass="52520" checksum="A688F501CF59C9F9" modified="2011-10-19" version="2">MSGFRVLDLVKPFSPFLPEVIAPERKVQFQQRVMWTIITLLIFLVMSEIPLYGIASSDSSDPLFWLRMMLASNRGTLMELGISPIVSSGMLFQLLQGTKIIHVDMQNKNDRETFQTAQKLLAILLAVGQATVYVLTGMYGPPSSLGVGVCSLLILQLVFASTIVILLDELLQKGYGLGSGVSLFTATNTCEQVFWKAFAPTTSTSAKGTEFDGAVVAMFHLLGSRKDKKRALIESFYRPNLPNMFQLLATLLVFFAVVYLQGFRIELPMKSTRQRGPYGSYPIRLFYTSNIPIMLESALASNIFIISQLLFMRWPNNLFVKLLGTWDARAGSSQLYANGGLAYYIQPPFNFTDALLDPIKTTIYIAFVLGSCAVFSTTWIEISGTSPRDVAKQFKEQGLVIAGHRDTSAYKELKKIIPIAAAFGGATIGALSVVCDLMGTLGSGTSILLAVTTIYGYYELAVKEGGFNKSIVSGFSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCW7</accession>
    <name>A0A1D8PCW7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cdc73p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">CDC73</name>
        <name evidence="8" type="ordered locus">CAALFM_C102920WA</name>
        <name evidence="7" type="ordered locus">orf19.10500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721481.2">
        <property type="nucleotide sequence ID" value="XM_716388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCW7"/>
    <dbReference type="SMR" id="A0A1D8PCW7"/>
    <dbReference type="FunCoup" id="A0A1D8PCW7">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCW7"/>
    <dbReference type="GeneID" id="3636830"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102920WA"/>
    <dbReference type="CGD" id="CAL0000176860">
        <property type="gene designation" value="CDC73"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02920W_A"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCW7"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000010">
        <property type="entry name" value="Uncharacterized protein Ca49C10.12c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000195198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="691" mass="79783" checksum="70C0C8E9C790EB15" modified="2017-01-18" version="1">MTIMATTTALSLPSSDVKTFHNYQVVLPTQLPIKRLYNPLKEQLIQSIKLPNDFNFKKKNNNANNANNEILVKVKMCGINYLSDFKSSAVNNGVIHKSRKPIVPGMRIICKIDSIKNIKFLVFPFTTCQLENIHNHPHLVRQQPLANKLEDSNNNNANSSVDHNCDLIYGKDIDGGLQTHLSVPKSLLIPIPYNISLHDVCFIFDILLPFYKFFQFVKPGKTIILLNDIKKELNEVLLILKIFNINFNSIIIIDGNSLSPRFNNKFETVYCFNRNLKYEAINYCVSTGLQATRSKYTVLTSFPVNVNSMLTNPKTHKRHNASTDSSISSISTLASNSSFKSASMMMGGVNSGTSNNNPNTISNNKFKNDKTIKYMQLSYQDKPLCIEVLKILSAINFEREDQEKQKTDQQQQQQQDKQQQDSPELAHDGIIDDYDYNYVDEYDENINEEKYRQLLINDNDSLVHSTSSTHTGSSTLQMHSQTESDPHGNIKNHAKKNEKKGKRRKVITRKYHHYSWIWCNKDVYLKNYYDLNDYDVNDLTNDIDNTDNENEYEYNYDEYGYSSSYHYRDGYDDDEYGIGDNHQNKIIKQMNRLLQDDVNLNRVCYFNSDDHDNDNDYKDDNDGYEDPEDVNGDDNHSYEYKKNTSTSHEDNNESNNYEDENSNQSSSSSGNRTYKSHRDRSWAKNINACII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDT0</accession>
    <name>A0A1D8PDT0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ACP1</name>
        <name evidence="16" type="ordered locus">CAALFM_C106060CA</name>
        <name evidence="15" type="ordered locus">orf19.9975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718462.2">
        <property type="nucleotide sequence ID" value="XM_713369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDT0"/>
    <dbReference type="SMR" id="A0A1D8PDT0"/>
    <dbReference type="STRING" id="237561.A0A1D8PDT0"/>
    <dbReference type="GeneID" id="3639825"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106060CA"/>
    <dbReference type="CGD" id="CAL0000199317">
        <property type="gene designation" value="ACP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06060C_A"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDT0"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000081">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002150">
        <property type="entry name" value="PRK00982.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000199317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="144" mass="16128" checksum="A46E4E11E57FDAB8" modified="2017-01-18" version="1">MFRTTLLKSLRASVSKPSIVKTIQSSSRSLFTITTITNNKNVTPLTSSMNFIRCYSAFPELTRDIAKERIIELLEGYDKVDQSKGEITEQSSFTSDLGLDSLDVVEVIMELEHEFNIQIPDNEADSLKTVGQTIDYILAQPDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDX3</accession>
    <name>A0A1D8PDX3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C106750WA</name>
        <name evidence="2" type="ordered locus">orf19.13615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718824.2">
        <property type="nucleotide sequence ID" value="XM_713731.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDX3"/>
    <dbReference type="GeneID" id="3639506"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106750WA"/>
    <dbReference type="CGD" id="CAL0000185887">
        <property type="gene designation" value="orf19.13615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06750W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PDX3"/>
    <dbReference type="OrthoDB" id="4017680at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="128" mass="14572" checksum="5903A5E815A3DAF5" modified="2017-01-18" version="1">MPNESIDNSGEVVFSQPNIDQKPPPPPPTSNTNFLTHVRSRSPSRSVSPYAYRTRSDDRQPIAYSGDNNTIIRETARSELITRHQLQNVHSDQSRRGRSRSREKKKVDTKPHVISLMGFDTTTTLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEK8</accession>
    <name>A0A1D8PEK8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C109430WA</name>
        <name evidence="13" type="ordered locus">orf19.12268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="A0A1D8PEQ8"/>
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    <dbReference type="GeneID" id="3634863"/>
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            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF12146"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="304" mass="34867" checksum="E0EC4709D66078BC" modified="2017-01-18" version="1">MTTVEIPYKPKGTPEIEFVEHNGANFKTVTWKVPQSVSYKGKIIYVHGFAEESNVYTEFFDNLSQNGYEVFFFDQRGAGETSPGNLVGLTDEFHVFNDLDFFIKRNLDARPAANSNEKFFLLGHSMGGGIILNYGIRGKYLNDIRAIVASGPLIQLHPNTQPNIVLRTLQPVISRLLPNFKIDSKLNFDYITSNERWKNYIIEHDKKLIGSVRQFNDMFVRGDALLKPEYVAKFKDDLPLLIVHGTNDNINDIKGSEQFFKLVPNDSGNKHLEKIEKGRHSLFIENDELFKLIFKRVVDFLNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFA9</accession>
    <name>A0A1D8PFA9_CANAL</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C111960CA</name>
        <name evidence="6" type="ordered locus">orf19.5269.1</name>
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    <organism evidence="7 8">
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330706.1">
        <property type="nucleotide sequence ID" value="XM_019475161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFA9"/>
    <dbReference type="SMR" id="A0A1D8PFA9"/>
    <dbReference type="FunCoup" id="A0A1D8PFA9">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFA9"/>
    <dbReference type="GeneID" id="30515060"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111960CA"/>
    <dbReference type="CGD" id="CAL0000185353">
        <property type="gene designation" value="orf19.5269.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11960C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PFA9"/>
    <dbReference type="OMA" id="LNAWSCV"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:RNA endonuclease activity"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
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        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="V-ATPase_su_f"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000185353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="84" mass="9263" checksum="1F95F9F89DF40216" modified="2017-01-18" version="1">MKPVVSTFQAYCCFITSSFAIVILSVIGYLFQTNSESFMGSINDPEDGKAVAKTVFSAVFVYLAFFAFCGLQILLIQRQSSIQL</sequence>
</entry>
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    <accession>A0A1D8PFG4</accession>
    <name>RL27A_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL27</fullName>
        </recommendedName>
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            <fullName>60S ribosomal protein L27-A</fullName>
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    <gene>
        <name evidence="2" type="primary">RPL27A</name>
        <name type="ORF">CAALFM_C112390CA</name>
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    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330710.1">
        <property type="nucleotide sequence ID" value="XM_019475165.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="AA=1-136"/>
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    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="AA=1-136"/>
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    <dbReference type="PDB" id="7Q0F">
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        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="AA=1-136"/>
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    <dbReference type="PDB" id="7Q0P">
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        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="AA=1-136"/>
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    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="AA=1-136"/>
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    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="AA=1-136"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="AA=1-136"/>
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    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="AA=1-136"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
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    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
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    <dbReference type="EMDB" id="EMD-13737"/>
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    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PFG4"/>
    <dbReference type="FunCoup" id="A0A1D8PFG4">
        <property type="interactions" value="1173"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFG4"/>
    <dbReference type="EnsemblFungi" id="C1_12390C_A-T">
        <property type="protein sequence ID" value="C1_12390C_A-T-p1"/>
        <property type="gene ID" value="C1_12390C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515062"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112390CA"/>
    <dbReference type="CGD" id="CAL0000176884">
        <property type="gene designation" value="RPL27A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12390C_A"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFG4"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
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        <property type="entry name" value="Ribosomal_eL27_CS"/>
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    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456503" description="Large ribosomal subunit protein eL27">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="136" mass="15514" checksum="510D9618BF1486D9" modified="2017-01-18" version="1">MAKFIKSGKVAIVVRGRYAGKKVVIVKPHDEGTKSHPFPHAIVAGIERAPLKVTKKMDAKKVTKRTKVKPFVKLVNYNHLMPTRYSLDVESFKSAVTSEALEEPSQREEAKKVVKKAFEEKHQAGKNKWFFQKLHF</sequence>
</entry>
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    <accession>A0A1D8PFJ7</accession>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Martchenko M."/>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Weissman J.S."/>
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        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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                <person name="Dungan J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        </location>
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    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ordered locus">orf19.11019</name>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Dungan J."/>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713143.1">
        <property type="nucleotide sequence ID" value="XM_708050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHX2"/>
    <dbReference type="SMR" id="A0A1D8PHX2"/>
    <dbReference type="FunCoup" id="A0A1D8PHX2">
        <property type="interactions" value="822"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHX2"/>
    <dbReference type="GeneID" id="3645199"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207450CA"/>
    <dbReference type="CGD" id="CAL0000188003">
        <property type="gene designation" value="RCL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07450C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PHX2"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="188"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000188003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="371" mass="40462" checksum="C8201AF09C7CAC89" modified="2017-01-18" version="1">MSSVASKKIITFEGHRNFRLRLVLATLSGKPIKITKIRSQDLNPGLKDHEVSFLRLLEAVTNGSHIEISYTGTTIIYRPGIIIGGDLTHNCPDTKSIGYFIEPMLMLAPFSKKKFSIIFKGLTNIAGNDTGVDAIKWGLLPVMEKFGVREVSLHILKRGSAPLGGGEVHLLCSSLIPQPLTIHALDIPKFSAIRGVAYCTRVSPSIVNRMIDSARAVLKPTGCEVNITADVWRGENSGKSPGFGITLVAESKRGWRIVTENVGSAGSLPEDSGELTAYQLLEEISNSGVVGRYQLPLALVYMTIGKEDIGRLKIQKSEIDENLVSVLRDIQEVFGTEAFFKDDAEELDSDDKFMTVSIKGVGFTNVSKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHY1</accession>
    <name>A0A1D8PHY1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Meiotic recombination directing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">MSC7</name>
        <name evidence="8" type="ordered locus">CAALFM_C207600CA</name>
        <name evidence="7" type="ordered locus">orf19.9421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713122.2">
        <property type="nucleotide sequence ID" value="XM_708029.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHY1"/>
    <dbReference type="SMR" id="A0A1D8PHY1"/>
    <dbReference type="FunCoup" id="A0A1D8PHY1">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHY1"/>
    <dbReference type="GeneID" id="3645214"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207600CA"/>
    <dbReference type="CGD" id="CAL0000189939">
        <property type="gene designation" value="MSC7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07600C_A"/>
    <dbReference type="eggNOG" id="KOG2454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHY1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="81"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000189939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="614" mass="68482" checksum="06A12F3FE52EE9D1" modified="2017-01-18" version="1">MIAIDLEFRQWQWQYQISTTFFIGVIVPVLYYVYNKYITAQPNNYNKIEAPVKITLPIPEEARPHWKGKRLYPPSISIPNEPDKIQSYCPATGQYLGVFNCTTREDMDEMINNASKAQKKWANSSFSLRRKLLKTMASFILENQENIARVACRDSGKTKLDASMGEIMVTLEKLNWIISHGEKVLRPSQRPGPANFLIGMMKNAEVRYEPMGVVTSIVSWNYPFHNLMGPVIASLFTGNAIIVKCSENVVWSSQWFIKFVRKCLQELAIDENLVQLCCCFPNDAEYFVSHPGLSHITFIGSKNVAHHVVSQAAKQLTPCVVELGGKDALIVLDDVKDVQSLSSVILRGTFQSAGQNCIGVERVICLPKVYEQLVEIFTERIKSFRVGSDIDQLDEIDMGAMISDNRFAQLEGLIEDAVSKGARLIHGGKQYQHPNYPQGHYFEPTLLVDVDPTMKIFQEEVFGPVLTMIRANDAEDAVNIANGTEFGLGNSIFGSNFNQVNQIADQLQSGNVAINDFATFYVAQLPFGGIKQSGYGKFGGEEGLTGLCNAKSVIMDKPLLRLFGVATSIPPPIDYPIENDKKAWNFVKSLNIAGYDGRLWNKVKALKNLATGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI33</accession>
    <name>A0A1D8PI33_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C207440CA</name>
        <name evidence="4" type="ordered locus">orf19.9443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713144.2">
        <property type="nucleotide sequence ID" value="XM_708051.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI33"/>
    <dbReference type="SMR" id="A0A1D8PI33"/>
    <dbReference type="FunCoup" id="A0A1D8PI33">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI33"/>
    <dbReference type="GeneID" id="3645200"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207440CA"/>
    <dbReference type="CGD" id="CAL0000190001">
        <property type="gene designation" value="orf19.9443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07440C_A"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI33"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000803">
        <property type="entry name" value="Steryl ester hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000190001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="567" mass="65519" checksum="4D9C8915ECBE0C73" modified="2017-01-18" version="1">MSEENPPQQDQQAPNVSDKPQGDSLITPRETHFHNVFVKYLIMLISALGSVIYTTVLCTGSILNHWFDIVSGREKTVLADIEQRSHGYVPREPYDELSKMKPTSDLQYYLQQLNLDLQEYRVTTCDGYILTLHRIIDPRESEEQRQQRKPVLLQHGLLSCSGTWIVSGKNSSGYYFHEQGYDVWMGNNRSWFIPQHKTLSGSLYNNEQYWDWGVQELAYHDLPALISTVLANKKYFQKLVLLGHSQGGLQSFLMLKNPRLGEIHEKVELFCPLAPAVYPGKLFYTRQFIKFINNRSEFMWLILFGCCAFLRNLCLVRHYIASSWLFGKLSYYMFKYLFGWTGRNWGPYKKVWHFCFIFNMSYASVELMKYYLSKHSDCGFTTLLQPKAAYSSDAHFTENVTDDKKSYFQFDTTWFSGIKVPMIVFIGDEDFLVDGEKVVAHMRKYEPGYREGSNFEAVSIPTYNHLDIVWAEDVIGTIGYTICNKLKQMKARDVQEGLTSESKEQAVTIPEGSSGHHQQQEEVGLNEKIVSVSEDIHDTELTTKVKHNLSADIPLTETRKLTTTEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJN2</accession>
    <name>A0A1D8PJN2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C303070WA</name>
        <name evidence="7" type="ordered locus">orf19.7936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719999.2">
        <property type="nucleotide sequence ID" value="XM_714906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJN2"/>
    <dbReference type="SMR" id="A0A1D8PJN2"/>
    <dbReference type="STRING" id="237561.A0A1D8PJN2"/>
    <dbReference type="GeneID" id="3638396"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303070WA"/>
    <dbReference type="CGD" id="CAL0000196638">
        <property type="gene designation" value="orf19.7936"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03070W_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJN2"/>
    <dbReference type="OMA" id="FILCWAM"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF14">
        <property type="entry name" value="AMINOTRIAZOLE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000196638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="505" mass="55784" checksum="B50D3C7521CC640B" modified="2017-01-18" version="1">MAVSLDPRPTIFTSSHHEIIVVTLICLAQFFTQAGITLSLSTMNIILKSFDTIDSAKQVWFMGSYALTVGTFILISGKLGDLLGLKLIFVIGWIWTTVFSAITGLSNYVSVEFFIICRALQGIGFALLIPCGMGILGNIYPNGERKNLVFGCVGANGPAGAFFGAFIAALIAQLWWWPWIFWLLSIGCVVLTIISMIYIPPITHHKLESYSEFFKRIDPLGTLTGIIGLILFNFVWTQGPVVGWNTAYIIALLIIAVLSIVAFFIIELYIAKYPLVPKSVFNLKIGMVLACISCGWGSFGIWQYYYWNIILNLRKYTPIAGSLTYVPFLVMGIIAAIASSIIISHTKPSYIISFSTICFMVGCLMLSVTPIQQSYFRLTLGQMFILCWAMDMSFPAASIILSDYLPNHHQGMAGSLVSTVINYSVSLFLGMSSCVETEIKLSTHNVLLSYRSGLYFGIGVASLGIFCSLIFIFVQRNDGKGTNALLVDSEEEIIRESTEDVMEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL94</accession>
    <name>A0A1D8PL94_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ordered locus">CAALFM_C401220CA</name>
        <name evidence="22" type="ordered locus">orf19.12138</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722738.2">
        <property type="nucleotide sequence ID" value="XM_717645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL94"/>
    <dbReference type="SMR" id="A0A1D8PL94"/>
    <dbReference type="STRING" id="237561.A0A1D8PL94"/>
    <dbReference type="GeneID" id="3635650"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401220CA"/>
    <dbReference type="CGD" id="CAL0000199703">
        <property type="gene designation" value="orf19.12138"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01220C_A"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL94"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="115"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0000199703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AOW28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="717" mass="80532" checksum="7BEF7598E78803AB" modified="2017-01-18" version="1">MNRKSTLNQKRSATISEFRFITEENTEANALSQQEQQQPQLKQDQSSLQQHKRTQSQTKLTKVLPYKVTRSKSVHAFQEYGKGFVGSPLMNSSIKSSQINSPQSKKLIKKQITPLQPTPPIISPIPIPQQPSTSIAVASEESRLPVPPPPSPPPVPQPPPPIHPSPFISNTIDDDNAQTSLSYSSNLLNYCQESVATPTYPVVATKNSDSGVRNATVIYRKKNTEELDYNLNEISPISYDTNSLRVVKRQSKLSANSKLEAHTLSNDFKLEKDKILSPDLEIVTAKAEDNDDTNIEIKQKNILETPTSFDNNQTPKIVGDNDSYTSPVSTELFSNITRRGFWWIIVILLGIIVILIGGFAPAVFILGKGTKTSVGKYFSDPKNLPMLYLLSSKYLTKVEEPLEHIHKPNSIEGLSEELRQDSEVVSLMSIVTNALFFGVAYSPSNALEPQCGFTRRDAMLDLARLSTITTKIRNYGMHCDQSEFILDAIEYMNLNMTLAMGVWIGSNDTVNEEQMNTMKRIVAKYPNPSELINSIYIGNEVLFREDKTRDELIEYIQDAKTFLQSKGIDDIPVGTSEIGSLVDSPLLQVCDIVGANIHPFFAGVPVEFATIWSLEFLNFQVQPYNEYNTKIVLSEIGWPSGGGTFGSSVASLSNSEYFANDFLCTFRDLPIEYYYFEAFDEPWKEIFWEGNRRWETQWGVFQDDRSPKFALQNIGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLA3</accession>
    <name>A0A1D8PLA3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">PWP1</name>
        <name evidence="7" type="ordered locus">CAALFM_C401450WA</name>
        <name evidence="6" type="ordered locus">orf19.12110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722712.2">
        <property type="nucleotide sequence ID" value="XM_717619.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLA3"/>
    <dbReference type="SMR" id="A0A1D8PLA3"/>
    <dbReference type="FunCoup" id="A0A1D8PLA3">
        <property type="interactions" value="1544"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLA3"/>
    <dbReference type="GeneID" id="3635623"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401450WA"/>
    <dbReference type="CGD" id="CAL0000198308">
        <property type="gene designation" value="PWP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01450W_A"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLA3"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001189">
        <property type="entry name" value="Periodic tryptophan protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002013">
        <property type="entry name" value="rRNA-processing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000198308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="613" mass="67938" checksum="3CD70E51377C0DA7" modified="2017-01-18" version="1">MISSSTWVPRGFAAEFPEKYELDDEEMERINAMANLELNDAKEQLAEAEGEEETEDNDSGNAPKTSKLVEQIEIDDDLKEYDLENYDNDEDQDDGNNLGNTKISMFPGLSNTDAKLLQDESGEGDKYLSLPTELDEQEEKKENQIYPTDNLVLATRTEDDISWLDIYIYDDGAGAPIGAEEEEEDKLDIDVANGMIRESNLYVHHDIMLPAFPLCVEWINYKPGQESSNIGNFAAIGTFDPQIEVWNLDFVDKAFPDVILGEPNKNSFIAKKNKKSKKKKKGGQHITTHHVDAVLSLSHNKIHRSILASTSADKTVKLWDLNSATAVCSFDKIHHNKTVSSSQWHSQEASILLTGGYDSTAAVTDVRISASESSSSSDSSKHYSVVAGEEVENVRWDLSKPELFYAGTDNGNVYSFDIRQDSKPLWTLHAHDAGISSLDVNNYVPGMLITSAMGEKVVKLWKCPSSSDENNTTKKQGPSMVLSRDFGVGNVLTTSYAPDIEVAGNVVIGGITGGLKMWDAFSNSSVRNGFREELIVLQNNARQEAKKNGRASRIARKYNSNSNKEEIMTVEAGGLKDESDSDSDEGEDVPIEMQEKEEEDDDDDEGMSDDDEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLH0</accession>
    <name>ERG8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ERG8</name>
        <name type="ordered locus">orf19.4606</name>
        <name type="ORF">CAALFM_C401870CA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Genet. Metab." volume="72" first="273" last="276">
            <title>Nonorthologous gene displacement of phosphomevalonate kinase.</title>
            <authorList>
                <person name="Houten S.M."/>
                <person name="Waterham H.R."/>
            </authorList>
            <dbReference type="PubMed" id="11243736"/>
            <dbReference type="DOI" id="10.1006/mgme.2000.3133"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="42" first="981" last="993">
            <title>Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.</title>
            <authorList>
                <person name="Murad A.M."/>
                <person name="d'Enfert C."/>
                <person name="Gaillardin C."/>
                <person name="Tournu H."/>
                <person name="Tekaia F."/>
                <person name="Talibi D."/>
                <person name="Marechal D."/>
                <person name="Marchais V."/>
                <person name="Cottin J."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="11737641"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02713.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Med. Mycol." volume="41" first="417" last="425">
            <title>Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans.</title>
            <authorList>
                <person name="Song J.L."/>
                <person name="Lyons C.N."/>
                <person name="Holleman S."/>
                <person name="Oliver B.G."/>
                <person name="White T.C."/>
            </authorList>
            <dbReference type="PubMed" id="14653518"/>
            <dbReference type="DOI" id="10.1080/1369378031000137233"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 7">Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:11243736). ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is regulated by the transcription factor NRG1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722678.1">
        <property type="nucleotide sequence ID" value="XM_717585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLH0"/>
    <dbReference type="SMR" id="A0A1D8PLH0"/>
    <dbReference type="FunCoup" id="A0A1D8PLH0">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLH0"/>
    <dbReference type="EnsemblFungi" id="C4_01870C_A-T">
        <property type="protein sequence ID" value="C4_01870C_A-T-p1"/>
        <property type="gene ID" value="C4_01870C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635640"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401870CA"/>
    <dbReference type="CGD" id="CAL0000200676">
        <property type="gene designation" value="ERG8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01870C_A"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLH0"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000069">
        <property type="entry name" value="Probable phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000454166" description="Phosphomevalonate kinase">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P17256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="11243736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11737641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="11243736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="14653518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="432" mass="48280" checksum="384D7FC05886B17E" modified="2017-01-18" version="1">MSKAFSAPGKAFLAGGYLVLEPIYDAYVTALSSRMHAVITPKGTSLKESRIKISSPQFANGEWEYHISSNTEKPKEVQSRINPFLEATIFIVLAYIQPTEAFDLEIIIYSDPGYHSQEDTETKTSSNGEKTFLYHSRAITEVEKTGLGSSAGLVSVVATSLLSHFIPNVISTNKDILHNVAQIAHCYAQKKIGSGFDVATAIYGSIVYRRFQPALINDVFQVLESDPEKFPTELKKLIASNWEFKHERCTLPHGIKLLMGDVKGGSETPKLVSRVLQWKKEKPEESSVVYDQLNSANLQFMKELREMREKYDSDPETYIKELDHSIEPLTVAIKNIRKGLQALTQKSEVPIEPDVQTQLLDRCQEIPGCVGGVVPGAGGYDAIAVLVLENQVGNFKQKTLENPDYFHNVYWVDLEEQTEGVLEEKPEDYIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLK4</accession>
    <name>A0A1D8PLK4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C402520CA</name>
        <name evidence="3" type="ordered locus">orf19.10263</name>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLW0</accession>
    <name>A0A1D8PLW0_CANAL</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
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        <name evidence="9" type="ordered locus">orf19.8890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
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        <property type="entry name" value="Transglutaminase-like_sf"/>
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        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
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    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="6">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="355"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="430"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000188578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="543" mass="63865" checksum="39905B0A0729F9AF" modified="2017-01-18" version="1">MVSYIIHARFRNQLIRSKRVQKLLKKLIPDQVKKIYKKFKKNMDMQSADEQLVYILKYLIKWFRKNFKHDSNGLRVLGYSSDPGKFPNNAKNISNESDLLAVIKKFQHNRDTGAQIFTAILSALGFESRLVFSIPLLSIKNTNTQPKLNHEILKVNKDNDLLYPYFWTELINPLDPSEIIVMETQCFYEEDKRLLRIKRYGGTLSQSFTDQFYPIQNQLCQMSMHYVLSLNSENLIVDVSSRYMKDISYRWFNRLDLRTDLGKSALLLQSLLRIFNRMKNYTTDDYKELDSLMQMAMINYTIPETFTAMKNSPNFITPSTLRYNEVIMPDTKPVKRIKINNKKEPVYFKNSLLVGKSEQQWKFLGRSIKPDQAPIKLAKATPRTIYNKRLYNQNEINDPSLNQVKLYSFSQTCPYIKLKVTKTTDGKLILPRNKYGNIEIFRENMIPDDCVWLKLTNIENILKNKAQFVPVVTGFAFKAGQAIPVKQGVIVLKQDEIPIKKIWLAGRIKEHKAQLAQRRLKLLYTWRFIYKHLQIKKRLDDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PME0</accession>
    <name>A0A1D8PME0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">I-AAA protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">YME1</name>
        <name evidence="19" type="ordered locus">CAALFM_C405670WA</name>
        <name evidence="18" type="ordered locus">orf19.8836</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716560.2">
        <property type="nucleotide sequence ID" value="XM_711467.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PME0"/>
    <dbReference type="SMR" id="A0A1D8PME0"/>
    <dbReference type="FunCoup" id="A0A1D8PME0">
        <property type="interactions" value="1132"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PME0"/>
    <dbReference type="GeneID" id="3641816"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405670WA"/>
    <dbReference type="CGD" id="CAL0000179642">
        <property type="gene designation" value="YME1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05670W_A"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PME0"/>
    <dbReference type="OMA" id="MSHFEWA"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="257"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="658"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000179642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW29299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="687" mass="75869" checksum="621C6B4D4C24B07F" modified="2017-01-18" version="1">MNSLSKIVPISRGIIYSQSSIRSLSTQILRSTNQHYLRSRQGSNPVANSRRFASHSTINLLQQQEQIANNELNNPQAQLEFYKTLLAYNYPHILVQRFETPGIASSPECVQLYIDALNKVGQTAKAAEVARQQQQHQTQYQTNGGNIGVGLPYGFGSRQEPVHVVVSESLLTILSKWLKWLIPIALLTYGATNAFNYLVENGTIFRNSETSDKSVDVSQSTVRFKDVQGCDEARAELEEIVDFLKDPSKFTGLGGKLPKGVLLTGPPGTGKTLLARATAGEAGVPFFFMSGSEFDELYVGVGAKRIRELFSQARDKAPAIIFIDELDAIGGKRNPKDQAYAKQTLNQLLVELDGFSQTEGIIIIGATNFPESLDKALTRPGRFDKEVIVDLPDVRGRIDILKHHMQNVETADDVDPSIIARGTPGLSGAELMNLVNQAAVHASQLSAPAVDMNHFEWAKDKILMGAAKKKMVITEESRINTAYHEAGHAIMAMFSKGATPLYKATILPRGRALGITFQLPEMDKVDMSKQECFARLDVCMGGKIAEEMINGKENVTSGCASDLSNATSVARAMVTSYGMSDKIGPVRLSDDWESWSPQIRNMADNEVRDYLLDSEKRTRKLLYDKRLELKRLAEGLLEYETLTKEEMEKVVKGEPINKAKTMSNTVIKKSSKSSEIKDILNDPMPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMM8</accession>
    <name>A0A1D8PMM8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C406710WA</name>
        <name evidence="5" type="ordered locus">orf19.10651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715448.2">
        <property type="nucleotide sequence ID" value="XM_710355.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMM8"/>
    <dbReference type="SMR" id="A0A1D8PMM8"/>
    <dbReference type="FunCoup" id="A0A1D8PMM8">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMM8"/>
    <dbReference type="GeneID" id="3642948"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406710WA"/>
    <dbReference type="CGD" id="CAL0000178432">
        <property type="gene designation" value="orf19.10651"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06710W_A"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMM8"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="183"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000178432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40474" checksum="C6FB9316E71394E3" modified="2017-01-18" version="1">MSAPKVATQVFLKTCPSGFIHTKVNEDDSTFEVKEVPVPELKEGQVLAKVLYLSNDPTQRTWLRKAGDNSPSYMPPVHEGTPMASLGLAEIIESKSEKYQKGDIASGRIYWADYAVVPDVVFFNKIDKSLGLPLEFFLSILGMTTLTAFFGLTEVGKLKKYLDGPKEGEKGPVVCVSAASGATGSSVVQIAKHLLGASKVIGISGSDEKCKWVESLGADLCVNYKNSEWKQQVSDYLAKDNEGIDVYFDCVGGEILSFILTKMNKFGHVAACGAISGYNDNKAFAVTSWPFIITNSLNVQGFIVGNFAAQFPEAIKILGAAVKEGKIKVQGAYHVEKLSGDEPSKRLADIPRIWNMLFEDNKPNGKLLIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMY6</accession>
    <name>A0A1D8PMY6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DNF2</name>
        <name evidence="28" type="ordered locus">CAALFM_C500570WA</name>
        <name evidence="27" type="ordered locus">orf19.8547</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="28 29" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="29">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="28 29" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716771.2">
        <property type="nucleotide sequence ID" value="XM_711678.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMY6"/>
    <dbReference type="SMR" id="A0A1D8PMY6"/>
    <dbReference type="FunCoup" id="A0A1D8PMY6">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMY6"/>
    <dbReference type="GeneID" id="3641589"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500570WA"/>
    <dbReference type="CGD" id="CAL0000173967">
        <property type="gene designation" value="DNF2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00570W_A"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMY6"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099039">
        <property type="term" value="P:sphingolipid translocation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
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        <property type="entry name" value="P_typ_ATPase"/>
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        <property type="entry name" value="P_typ_ATPase_c"/>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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        <property type="entry name" value="ATPase_P-type"/>
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        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
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            <begin position="1304"/>
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            <end position="1409"/>
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            <end position="1441"/>
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            <end position="1470"/>
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            <begin position="1490"/>
            <end position="1509"/>
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            <begin position="249"/>
            <end position="310"/>
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            <end position="1519"/>
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            <dbReference type="RuleBase" id="RU362033"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF16212"/>
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            <dbReference type="CGD" id="CAL0000173967"/>
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            <dbReference type="EMBL" id="AOW29500.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    <sequence length="1716" mass="195483" checksum="95E8B782F94E0CB8" modified="2017-01-18" version="1">MTKNKHNFTLNNSSDGVNNNDDPSDHHDYSDDSMPPTPTISTFNKFPRQSSLRFKTPLPNDTPRSSSSGSTSNNNNHNHNQKSPFLDENEASFDRKFGYNYDKDKVVEEEDENEDEATYVVGEDNEDNEDENDNINEMDPSNLKTKRHRWGTTRHKHGRPKNENINRSKTLKKILAPHKSKGKSHSKNSHSLNKRLLSIRKPNTHRVNFPHDNQPPPQDLDFEEQNDPKNRKSEKRTVTFNRPLPPHLVDPETNKPLTNYPRNKIRTTKYTPLSFFPKNIWNQFMHNVANIYFLVLIILGAFEIFGVPSPVLAAVPLIVIVIITAIKDAIEDSRRTVTDLEVNNQITHILTQVNEDAANGYHYENVNVDDEQVSYWRQFKKWNTRLLIRFWGASKRNLTKEGRANKIRERYNRENNIDGDGDQQQGRKSFDSDIVSNRTSFEQTENPFNDTLRQSFQQQRQQQQRQSSSYRHKTMKFAKKYWKDVKVGDVLRIYNNDEVPADLVILATSDEDNCCYVETKNLDGETNLKVKQALKYSSINEKIHKADDLINHDFEIDSEGPHANLYSYQGNLKYTNRMNNSQSYDNHEDSQEAITINNLLLRGCTLRNTKWAIGIVVFTGDDTKIMLNAGVTPTKQSRMSRELNYYVLLNFILLFVICFISGLVNGIYYRETNTSRDYFEFGTIASTPALNGLVGFFVSLILYQSLVPISLYITIEIIKTAQAFFIYSDVGMYYSKLDFPCTPKSWSISDDLGQIEYIFSDKTGTLTQNLMEFKKCTINGVSYGKAYTEALAGLRKRMGIDVEIEAAQERELISRDKEVMIEKLHTINKNKTYDDEITFVSSEFIDDLTDSSINNQQQRESNHHFMLALALCHSVMTEPDPKQPNKLMLKAQSPDEAALVGTARSLGFNFKGTTKTGVIVDVHGETKEYQVLNTLEFNSTRKRMSSIIKIPGEGPNDEPRALLICKGADSIIYERLSATENDPSMLEKTSKHLEEYATEGLRTLCIAERELSWKQYVEWNKRHQAAASSLDDREAKMEAVADSIERELTLLGGTAIEDRLQDGVPDAISILADAGIKLWVLTGDKVETAINIGFSCNLLGNDMQLLVIKTAYNDDENGSNDDNSSEDKNSLQGLKFGHNASEPEIVDTVISYYLRKHFDMTGSFEEKEAAVGDHSPPDERFGVVIDGDALKLVLLSPDVKRKFLLLCKKCRAVLCCRVSPAQKAAVVKLVKDTLNVMTLAIGDGSNDVAMIQAADVGVGIAGEEGRQAVMSSDYAIGQFRYLARLLLTHGRWSYKRFSEMIPSFFYKNIIFNIALFWYGIYCDFDGTYLFEFTYLMFYNLAFTSLPVIFLGIFDQDVEAKVSLLVPQIYRTGITRTEMSDLKFYLYCLDGIYQSAISYFFPYLLYMVAFPNMNGKPVDHRFWMGVLVTCIACISCNCYILFHQFRWDWLSSLIVAISILIIFIWTGLWTVNYQSSGEFYKAAPEIFGMTAFWACMFVGILCCLIPRFFYDFVMRIFWPKDIDIIRECVARGDFEAYPFDYDPTDPNRPKISTYSSDVVHRMSMNYPSPPQTQATSTDSNGKSPSSSSLDNGHQSRNSNNLNGNGYYDQDNSSGSNLTYDRSIIFERVNESPINAHHQQPPTPPPGIIASPIRKRKGFVPSVFRNSSDSHIHHSNGHTNGSSPGVATEEIPLEDFDDEQKRASRISYENQKRVSSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNQ4</accession>
    <name>A0A1D8PNQ4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C503650CA</name>
        <name evidence="1" type="ordered locus">orf19.6678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Martchenko M."/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000191573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="347" mass="38950" checksum="BD18DFF39DE0BDC5" modified="2017-01-18" version="1">MPVKSKENLPWVEKYRPDSLEEVKGQQEIVDTVRKFVETGKLPHLLFYGPPGTGKTSTIIALAKEIYGATNYKNMILELNASDDRGIDVVRNQIKNFASTRQIFTKNTSQTASNNQFKLIILDEADAMTNVAQNSLRRVIEKFTKNCRFCILANYSHKLNPALISRCTRFRFTPIDISAIKDRLNTVIIKENVNISPEAIDALLKLSNGDMRRALNVLQSCKAALGDEEKEEDGHANDEIDVDMIYDCVGAPHPQDVETCLDSILKDDWTTAYLTLNKYKTIKGLALIDLITGFIEILNNYKLKPKTRLEILKGLSDIEYGISKGGNDKIQTSAIIGVIKDAMEFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP08</accession>
    <name>A0A1D8PP08_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">MSM1</name>
        <name evidence="13" type="ordered locus">CAALFM_C504650CA</name>
        <name evidence="12" type="ordered locus">orf19.11432</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721859.2">
        <property type="nucleotide sequence ID" value="XM_716766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP08"/>
    <dbReference type="SMR" id="A0A1D8PP08"/>
    <dbReference type="FunCoup" id="A0A1D8PP08">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP08"/>
    <dbReference type="GeneID" id="3636398"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504650CA"/>
    <dbReference type="CGD" id="CAL0000183257">
        <property type="gene designation" value="MSM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04650C_A"/>
    <dbReference type="eggNOG" id="KOG0436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP08"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000116">
        <property type="entry name" value="Methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000183257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="577" mass="67022" checksum="D48FA403109A1128" modified="2017-01-18" version="1">MRFKIRGPLIQLRYKSTKPFYITTPIFYVNAAPHIGHLYSMLIADTRNKWEKLNPSKESFMLTGTDEHGLKIQSTAEKLGLEPKVLVDKVSQNFSKLAEQFDVNYDRFIRTTDNDHIELVRYFWNLMMEKGFIYTDTHSGWYSISDETFFPETQIEEVVKNGKAVKISSETKNEVVYQKETNYFFKLSMFQEQLIQFLKQNPEFIKPKHRYQFILKELEDTKLPDLSISRPSSRLKWSIEVPNDSTQKIYVWFDALLNYLTATKFPHGFEVQDSKFVTPENSIWPATHVIGKDIIRFHCIYWPIFLMAAGIELPKQVIVHSHWLCDGFKMSKSLGNVVDPMEISEYYGVDPVRFFLVENSNIDDDCKFSEELLQRSRDAVLGKYCNLISRIGGKNFSIEEAVKSSASGEFNNIREIIETYTINKDSVEGLLSSSSKLTTDLNDLYNQMDHYFTNFDYIRAIQCWWSVINQANQIFQSAEPWTYVKLINSPETPAELKEKYRILNNYFVYLCAETTRISSILIQPVMPQLSKKILDRLNVSGRTSEFTTFGADLQYGSGANSKSHKVPLEKIAPRDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP96</accession>
    <name>A0A1D8PP96_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2-21 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme PEX4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Peroxin-4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">PEX4</name>
        <name evidence="14" type="ordered locus">CAALFM_C505430WA</name>
        <name evidence="13" type="ordered locus">orf19.11524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="9 10" key="2">
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the TAPT1 family.</text>
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    </evidence>
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        </lineage>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30684.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_706583.2"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1D8PRD5">
        <property type="interactions" value="1247"/>
    </dbReference>
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    <dbReference type="GeneID" id="3646717"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03400C_A"/>
    <dbReference type="eggNOG" id="KOG0948">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:RNA exonuclease activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
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        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
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        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Beta-barrel_MTR4"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="MTR4-like_stalk"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNA-DNA_Helicase"/>
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        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
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        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
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    </dbReference>
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        <property type="entry name" value="DEAD"/>
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    </dbReference>
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        <property type="entry name" value="DSHCT"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="Antiviral_helicase_SKI2"/>
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        <property type="entry name" value="DEXDc"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="149"/>
            <end position="305"/>
        </location>
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        <location>
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            <end position="589"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000198236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120539" checksum="4CC17E0A7230AC21" modified="2017-01-18" version="1">MDDLFDVFDEAPQAAPPKIEEIKDEVKPETTDNQTRSTKKRQFDNNNKTTTNSNNSSSSNNKKHKQAEDIKPVVFDSVEIETSREVKPSEGLSNSATVDADNKLKLKHQIRHQVAIPPSYPYVPIGEHKRKHEARTYPFTLDPFQDTAISCIDRNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIYTSPIKALSNQKFRELQAIFGDVGLMTGDVTINPDAGCLVMTTEILRSMLYRGSEVMREVAWVVFDEVHYMRDKSRGVVWEETIILLPDKVHYVFLSATIPNAMEFAEWIVKIHNQPCHVVYTDFRPTPLQHYLFPAGGDGIHLVVDEKGTFREENFQKAMATISDNSGDDPASSDSGRGNKKGKTNKGRNHQDGKGDIYKIVKMIYMKKYNPVIVFSFSKRDCESLALKMSKLDFNTDEERNSLTQIFYNAIELLPEADRELPQIKNILPLLKRGIGIHHSGLLPILKEIIEILFQEGFLKVLFATETFSIGLNMPAKTVVFTSVRKWDGVGFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMIDEKMEPQVAKGMVKGQADRLDSAFHLGYNMILNLMRVEGISPEFMLEHSFFQFQKASSVPILEGKLAQCKQEFADITIEDEPIIKDYYDLKQQLLKYNEDVRKVITHPGNILPFLQDGRVIKVKIGDLDYGWGMVTTFTKRNRRHQEEFAPHDAYVVEVFITTMFIDSPVNLIKKFNPMLPEGIRPAKSGEQTRAEFISITLSSIEKISTVRLRVPDDYKSSTAKRTLVKTLKDLPKRLPDGIPLIDPVQSMKITDDDFKKLLQKIDILDSKIVSNPLNNSARLDDLYAKYTAKVDLNNQIKKLEEQIFQAKSIIQLDQLSNMKRVLKKLEFTGSEEVVELKGRVAAELSTGDELMITELLFSGFFNELTPQQICGLLSAFIFQERAKELPKLKPELAEPAKVIHETANKIAKISKQSGLEIVEKDYIEQFNLALVEVVFVWSNGASFSSICKMTDIYEGSIIRALRREIELIKQLVDASKIIGNQELVDKFEKCIELINRDFVQVSSLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRT2</accession>
    <name>A0A1D8PRT2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">VHR1</name>
        <name evidence="3" type="ordered locus">CAALFM_CR00630WA</name>
        <name evidence="2" type="ordered locus">orf19.7468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718626.2">
        <property type="nucleotide sequence ID" value="XM_713533.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRT2"/>
    <dbReference type="SMR" id="A0A1D8PRT2"/>
    <dbReference type="FunCoup" id="A0A1D8PRT2">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRT2"/>
    <dbReference type="GeneID" id="3639690"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00630WA"/>
    <dbReference type="CGD" id="CAL0000178228">
        <property type="gene designation" value="VHR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00630W_A"/>
    <dbReference type="eggNOG" id="ENOG502QVE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRT2"/>
    <dbReference type="OMA" id="FVMERFF"/>
    <dbReference type="OrthoDB" id="4089008at2759"/>
    <dbReference type="PHI-base" id="PHI:11474"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006768">
        <property type="term" value="P:biotin metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
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        <property type="entry name" value="TF_Vhr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04001">
        <property type="entry name" value="Vhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
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        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000178228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="537" mass="61244" checksum="EB778C69D260B84B" modified="2017-01-18" version="1">MEHNKKLGVTHAIREKLNFHDERLWKRFSARRLELIDTLDLSSRKASEQESEIRRVSEMLRLEFDYPASYTSDFNKLVRAAIQSVRRNRKRSSKKHTSPEEPSLKRNKLDDSDSNGNVNGSNSNSFLSEIVRNEDDVYDVNYNREKRFTSDDQAKDTIDNMTKPRLPPLTNLSMNETINIPSAAAAKKNILNKIEKSRSCNESVNSKSENLQFLGKSVMSTCIGYIFEKSFSHVNPQSMLYLRNKLSSELSLSKFFRQLDPVNTNGINDETAVISLYILLGAMVKDFGFEEVIFPICEILYASVLQEYPLMAKNSIPFRNEDQHLGSNNIAYPSENDVYSLNKLAEVASHLQNTGSDTSMSTMEPSRSVTPTSSLTGSYKKRVYLKFFNQKLEFLYPVRIAATPRYNELLENAKSAFKLPDTTIVFKHHGKIVQSDLELERVFKSDEDEIELEISTHNPMPIYEMHKRLSQQDYQQPTESQRIILPPPIASNTAMSNGSSLNSRLGSFNFLSNSDDVPGPKPLHPQQSILPKFQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS44</accession>
    <name>A0A1D8PS44_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR02060WA</name>
        <name evidence="1" type="ordered locus">orf19.10138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome R"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35905" checksum="B59B8DFCC5813B9D" modified="2017-01-18" version="1">MSLLIPTPRDRHDAHGDLEEDNAYYNLLIKEQNSTNNRYIWKFKPVKGFFKQTDEQTDDMAFRYTEQKLGRLDDWEKIVADLQQLNRDSPDNEIYKLIFLARHGQAKSNVASQKYSKEEWMRKWRFLGTDGELTWGPDADLTELGLKQAAENHQCWKQQLLEGAPYPKRFYVSPLQRSIKTHNITWPNTKPIVLENLRETIGLHLCHKRSNKSSLKEKFPNLVFEDGFTEEDLLFDKYLPRKEHLHEQFLRINGVLQDIFNSDEEDILCITSHAGTIRAFITVLSHRKFTIPTGGMIPVVIKATRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSB1</accession>
    <name>A0A1D8PSB1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_CR02800CA</name>
        <name evidence="7" type="ordered locus">orf19.10356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="2"/>
    <dbReference type="EMBL" id="CP017630">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_CR02800CA"/>
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    <dbReference type="OMA" id="QFACASY"/>
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        <property type="component" value="Chromosome R"/>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR054593">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
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        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSD3</accession>
    <name>A0A1D8PSD3_CANAL</name>
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        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_CR03130WA</name>
        <name evidence="7" type="ordered locus">orf19.9950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_708152.2"/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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        </source>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
    </reference>
    <reference evidence="3 4" key="3">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        </source>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
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        </source>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        </source>
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    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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    <reference evidence="14 15" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
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            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
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</entry>
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        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW31407.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705081.1"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome R"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
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            <end position="153"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31407.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43946" checksum="85D9EE6E1A2EE12A" modified="2017-01-18" version="1">MYQSMTVPPFRPYGGDDIRVVSDLSRFDYQPDQKIRSRNPTPPSTINDNVSSSKLTLDTIIPLYSSKIDERPKYSPLRQQEDRSTQYPSPPIPVKEEPTITIPKREKKKVRYSIGVQVPQDNGGISMTNNPAPPAPVPVPVPAPAPPPPPPKDIAPRSMPYPQDINNANNLPPMPQPTSQLYPQQQLPPLPYKDSSSITSPQKRLEKKLIKQVMNRPVIQFKADRFGQNYEGEYFTISANFVIYVFEVCCSVVEIVLSSILLQRDQDIGVGYYRYFLADGIISLIVSLLFALQVINYEIRNGIFYCLVSTICKFVSFIFIISHIFPHNTYATHEIWQMRRGVGAIIIISTFLWVTNMTMFVTTLYISRLDLLEELNFDYSEVNKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTJ5</accession>
    <name>A0A1D8PTJ5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA replication initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">CDC45</name>
        <name evidence="8" type="ordered locus">CAALFM_CR07720CA</name>
        <name evidence="7" type="ordered locus">orf19.2634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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                <person name="Magee B.B."/>
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    <dbReference type="STRING" id="237561.A0A1D8PU18"/>
    <dbReference type="GeneID" id="3639012"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09780CA"/>
    <dbReference type="CGD" id="CAL0000180488">
        <property type="gene designation" value="IFA14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09780C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PU18"/>
    <dbReference type="OrthoDB" id="1111193at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000180488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="678" mass="79195" checksum="F10883C80E5186EB" modified="2017-01-18" version="1">MAIPYIDINLFLLLSRFPNEVLDHIISYIPKCMLPELLYFRSIKPFVEYRVLMNVAIKFSVQRHRRMDAFGYDYIWCDCTGFKITLNNLKIAINRLHIFPHIIHFEYINDLMDLVHSYPDLGRRLLKINGTFNSFDFQNLENLMTLMDQSQIRFDTLALSNFNYSFPLPPIATNLSLFNCLVADYMIQGLRKLNLVIDHPSIQDRIVTFPDSLEELLIDTSVNISVIPSPSLRELSLITFSNNVNFMFQEMSKLEYLWIQIPDFESFNDIGIVAPNINTLELSDCYHMNNFGELTQFQHLKHLKIKRCAFPIGLFEEFQFPELEIFTYNGHDRVYLKDAYNPRLPFPQNLKCLSIKSYDLDSIHPYNLELPAGLERLELMYLTFSDGYFHFGDNLRYIRIYTPTLTFHEDFRLPQSAQEFILNADCLTFDRSYFLHKLPENLVRLHLIANKLCVMRPITKKIQWPSMLSSLYLKGFAINSGILKLLNLRQTCLEEITICGGYVPILSEEMFPVSVKELTLQRMGIRSLSSSFKSLKNLQRLSLIRNNLKDISSVRLPLATLKSLDLSYSHVPLLTPFLIAFSSEKYKNAELEVDARGNQEIDINDVLMAMQEYRRLSVCLSMINGTRTQLPMDPTRLEFVYESFDSYHERYENSDNDPDDMDSDGEDDDVERRRMGLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>P56553</accession>
    <accession>A0A1D8PLN2</accession>
    <accession>Q5AF85</accession>
    <accession>Q5AFX1</accession>
    <name>CGR1P_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cell growth-regulated gene 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CGR1</name>
        <name type="ordered locus">CAALFM_C402760CA</name>
        <name type="ORF">CaO19.10237</name>
        <name type="ORF">CaO19.2722</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Biochim. Biophys. Acta" volume="1517" first="288" last="292">
            <title>Isolation and expression of a gene (CGR1) regulated during the yeast-hyphal transition in Candida albicans.</title>
            <authorList>
                <person name="Cho T."/>
                <person name="Sudoh M."/>
                <person name="Tanaka T."/>
                <person name="Nakashima Y."/>
                <person name="Chibana H."/>
                <person name="Kaminishi Y."/>
            </authorList>
            <dbReference type="PubMed" id="11342110"/>
            <dbReference type="DOI" id="10.1016/S0167-4781(00)00243-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>JCM 9061</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Involved in the cell growth regulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AB013716">
        <property type="protein sequence ID" value="BAA28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720472.2">
        <property type="nucleotide sequence ID" value="XM_715379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P56553"/>
    <dbReference type="SMR" id="P56553"/>
    <dbReference type="BioGRID" id="1220947">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="P56553">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P56553"/>
    <dbReference type="EnsemblFungi" id="C4_02760C_A-T">
        <property type="protein sequence ID" value="C4_02760C_A-T-p1"/>
        <property type="gene ID" value="C4_02760C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637853"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402760CA"/>
    <dbReference type="CGD" id="CAL0000196952">
        <property type="gene designation" value="CGR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02760C_A"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="InParanoid" id="P56553"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="PRO" id="PR:P56553"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000173051" description="Cell growth-regulated gene 1 protein">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA28176." evidence="1" ref="1">
        <original>INT</original>
        <variation>TNI</variation>
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA28176." evidence="1" ref="1">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA28176." evidence="1" ref="1">
        <original>P</original>
        <variation>S</variation>
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="340" mass="38414" checksum="4A824993A13ECBF9" modified="2007-03-06" version="2">MSLTITKDNIFPKGYRGRLTEGVTYDERNNTLLWVDIIQGEVHRVFLDNTNINTNTSSSSHETLKWDSSNESIGAICLTNDPNKLIICSKYGLAYGDFSSSTIEYFFKYPHTTNPDEKLRLRSNDGIIDPWGNLWIGVMNDFPIGAKEGIQPEGKLYRIGFSKESNKLTCDVMIENSLISNGLCFNNQGDEFYWTDSLTFKIWKYDYDKTTNKLTNKSVFIDLKQFYPDVEQPEPDGLVMTNNGEIYTCVFSTGTILHVDNQGKEIERIKIAAKRPTCVTIGSGIKNNEMFVTTGHLKLDDEKATIDAINLDGDLGGFLFKLKVDKDLNGQKKNIWGGKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KF3</accession>
    <accession>A0A1D8PQB8</accession>
    <accession>Q59KF8</accession>
    <name>SPB1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AdoMet-dependent rRNA methyltransferase SPB1</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2'-O-ribose RNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SPB1</name>
        <name type="ordered locus">CAALFM_C604160CA</name>
        <name type="ORF">CaO19.76</name>
        <name type="ORF">CaO19.7727</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710224.1">
        <property type="nucleotide sequence ID" value="XM_705132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KF3"/>
    <dbReference type="SMR" id="Q59KF3"/>
    <dbReference type="FunCoup" id="Q59KF3">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59KF3"/>
    <dbReference type="EnsemblFungi" id="C6_04160C_A-T">
        <property type="protein sequence ID" value="C6_04160C_A-T-p1"/>
        <property type="gene ID" value="C6_04160C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3648179"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604160CA"/>
    <dbReference type="CGD" id="CAL0000201177">
        <property type="gene designation" value="SPB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04160C_A"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="InParanoid" id="Q59KF3"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="PRO" id="PR:Q59KF3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070039">
        <property type="term" value="F:rRNA (guanosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155593" description="AdoMet-dependent rRNA methyltransferase SPB1">
        <location>
            <begin position="1"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="739"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="845" mass="96820" checksum="0FA5DE332ECA6767" modified="2005-04-26" version="1">MGKQQKKHSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASQLCPINSLIIGVDIVPIKPLPNVITFQSDITTEDCRSRLRGHMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLTAGGTFVTKIFRSRDYNNLMWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKKLDPRLLDPKEVFEELGGGNESKQNNEAKIFNPEKFSSQRQRQGYQEGDYTLFHTMPIMDFIKQDDPINQLGSLNKFDLPAPKDDDNDDDDHDHEWKILSKLKLCTPELLECIKDLKVLGRKEFKMILKFRKQARDILGIDKDEKEEEEENPKIEVEPLTEEQKIDQELQDLINKQKQKAKRLKKNANELKQKEIIRNQMNMLTDMNIGIEAAQIGADSLFNLKTAEKTGQLDKLAKGKKKMIFNDEELAKDNEIHIDEEEINDNDKDSADELDELENQLDDMYHQYQARKAERDANYRAKQARGDADDEAWNGIEEDNDDVESGKDYEMESESDDDDDEHIRLIAEKKSNGSLSRTARNFFASDSIFNELSDDVILEEIENKTKGSNGKMVESIQEQVANDNNENDDGDNDEEESDFEIVPNQKSDDDDDDESMNSDDDEVSTTTKSTTHQQKVDLATVEAMTLAHQVALGQKNKYDLIDEGINRYSFRDKDNLPDWFIDDEKKHSKLIKPITKEAAIAIKEKQKQLNARPIKKVLEAQSRKKLRALKRLEKIKKKSDLINEDSGKSERDKADEISKLMKKLNKKQKQKPKTTVVVARGSNRGLSGRPKGVKGKYKMVDGVMKNEQRALKRIAKKYKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MJ2</accession>
    <accession>A0A1D8PKX6</accession>
    <accession>Q9P8Q3</accession>
    <name>MCH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MCH1</name>
        <name type="ordered locus">CAALFM_C307850WA</name>
        <name type="ORF">CaO19.6180</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="FEMS Yeast Res." volume="2" first="315" last="325">
            <title>Gluconeogenesis in Candida albicans.</title>
            <authorList>
                <person name="Eschrich D."/>
                <person name="Koetter P."/>
                <person name="Entian K.-D."/>
            </authorList>
            <dbReference type="PubMed" id="12702281"/>
            <dbReference type="DOI" id="10.1016/S1567-1356(02)00087-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-264</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probable transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222906">
        <property type="protein sequence ID" value="AAF34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710936.1">
        <property type="nucleotide sequence ID" value="XM_705844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MJ2"/>
    <dbReference type="SMR" id="Q59MJ2"/>
    <dbReference type="FunCoup" id="Q59MJ2">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q59MJ2">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_07850W_A-T">
        <property type="protein sequence ID" value="C3_07850W_A-T-p1"/>
        <property type="gene ID" value="C3_07850W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647466"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307850WA"/>
    <dbReference type="CGD" id="CAL0000193330">
        <property type="gene designation" value="orf19.6180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07850W_A"/>
    <dbReference type="eggNOG" id="ENOG502QTNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_3_0_1"/>
    <dbReference type="InParanoid" id="Q59MJ2"/>
    <dbReference type="OMA" id="PTMWWLA"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000084868" description="Probable transporter MCH1">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="436" mass="47815" checksum="436EE9DFB8A71994" modified="2005-04-26" version="1">MHKHLHHVSHTIKSYLSTLIALENLKVVAFLISLLSCLVAGSILLFTLYTSSFHEVLGLSYLQINMISSLSALGMYFCLPVLGYLADSYGPALLSLFSIWFFCPSYFVNSYLVSTQSGSVIGFCVCFCFIGLATSSLYFSSLITCARICPDHKGLAISLPITCYGLSALLGAQILKLPYFHRHDVLDLEVVFSFFAWLYLVVGIASFVSSSIVIVESELLFGVTPDEETALLELTPTRSLEPPNHRQRFVSFVKDPSAWILLVSLILNIGPMESYQNNLSSILKHTNGADLPNQVSIMAASSTGARLLLGVLSDYSSKYVCRVWLLVVVIVVGVAGQMSETSAILNGVSYGGMFTIYPTIVASIWGIDIMGSTWGSFMVAPALGSVIFSMFYGRNADSCSDCLSHYFYTTAGAMIVSCIFVLLAWKIWYARGFTRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NP5</accession>
    <accession>A0A1D8PPG8</accession>
    <name>SUN41_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Secreted beta-glucosidase SUN41</fullName>
            <ecNumber>3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SUN41</name>
        <name type="synonym">SUN4</name>
        <name type="ordered locus">CAALFM_C600820WA</name>
        <name type="ORF">CaO19.11124</name>
        <name type="ORF">CaO19.3642</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
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                <person name="Jones T."/>
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                <person name="Chibana H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="van het Hoog M."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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            <authorList>
                <person name="Muzzey D."/>
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                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="J. Mol. Biol." volume="361" first="399" last="411">
            <title>Transcriptional response of Candida albicans to hypoxia: linkage of oxygen sensing and Efg1p-regulatory networks.</title>
            <authorList>
                <person name="Setiadi E.R."/>
                <person name="Doedt T."/>
                <person name="Cottier F."/>
                <person name="Noffz C."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="16854431"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2006.06.040"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="1713" last="1720">
            <title>Inactivation of Kex2p diminishes the virulence of Candida albicans.</title>
            <authorList>
                <person name="Newport G."/>
                <person name="Kuo A."/>
                <person name="Flattery A."/>
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                <person name="Blake J.J."/>
                <person name="Kurtz M.B."/>
                <person name="Abruzzo G.K."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="12419804"/>
            <dbReference type="DOI" id="10.1074/jbc.M209713200"/>
        </citation>
        <scope>PREDICTION AS A SUBSTRATE FOR KEX2 CLEAVAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Mol. Microbiol." volume="47" first="89" last="102">
            <title>EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays.</title>
            <authorList>
                <person name="Sohn K."/>
                <person name="Urban C."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="12492856"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2003.03300.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="2226" last="2236">
            <title>Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.</title>
            <authorList>
                <person name="Liu T.T."/>
                <person name="Lee R.E."/>
                <person name="Barker K.S."/>
                <person name="Lee R.E."/>
                <person name="Wei L."/>
                <person name="Homayouni R."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="15917516"/>
            <dbReference type="DOI" id="10.1128/AAC.49.6.2226-2236.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="66" first="1256" last="1275">
            <title>The SUN41 and SUN42 genes are essential for cell separation in Candida albicans.</title>
            <authorList>
                <person name="Firon A."/>
                <person name="Aubert S."/>
                <person name="Iraqui I."/>
                <person name="Guadagnini S."/>
                <person name="Goyard S."/>
                <person name="Prevost M.C."/>
                <person name="Janbon G."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="18001349"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2007.06011.x"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2007" name="Eukaryot. Cell" volume="6" first="2046" last="2055">
            <title>Requirement for Candida albicans Sun41 in biofilm formation and virulence.</title>
            <authorList>
                <person name="Norice C.T."/>
                <person name="Smith F.J. Jr."/>
                <person name="Solis N."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="17873081"/>
            <dbReference type="DOI" id="10.1128/EC.00314-07"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2007" name="Eukaryot. Cell" volume="6" first="2056" last="2065">
            <title>Candida albicans Sun41p, a putative glycosidase, is involved in morphogenesis, cell wall biogenesis, and biofilm formation.</title>
            <authorList>
                <person name="Hiller E."/>
                <person name="Heine S."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="17905924"/>
            <dbReference type="DOI" id="10.1128/EC.00285-07"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2009" name="J. Proteomics" volume="73" first="342" last="351">
            <title>A proteomic analysis of secretory proteins of a pre-vacuolar mutant of Candida albicans.</title>
            <authorList>
                <person name="Thomas D.P."/>
                <person name="Lopez-Ribot J.L."/>
                <person name="Lee S.A."/>
            </authorList>
            <dbReference type="PubMed" id="19819358"/>
            <dbReference type="DOI" id="10.1016/j.jprot.2009.10.003"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2009" name="PLoS Pathog." volume="5" first="E1000601" last="E1000601">
            <title>Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans.</title>
            <authorList>
                <person name="Sahni N."/>
                <person name="Yi S."/>
                <person name="Daniels K.J."/>
                <person name="Srikantha T."/>
                <person name="Pujol C."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19798425"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000601"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1071" last="1081">
            <title>Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.</title>
            <authorList>
                <person name="Sorgo A.G."/>
                <person name="Heilmann C.J."/>
                <person name="Dekker H.L."/>
                <person name="Bekker M."/>
                <person name="Brul S."/>
                <person name="de Koster C.G."/>
                <person name="de Koning L.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="21622905"/>
            <dbReference type="DOI" id="10.1128/EC.05011-11"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="13387" last="13396">
            <title>SUN proteins belong to a novel family of beta-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis.</title>
            <authorList>
                <person name="Gastebois A."/>
                <person name="Aimanianda V."/>
                <person name="Bachellier-Bassi S."/>
                <person name="Nesseir A."/>
                <person name="Firon A."/>
                <person name="Beauvais A."/>
                <person name="Schmitt C."/>
                <person name="England P."/>
                <person name="Beau R."/>
                <person name="Prevost M.C."/>
                <person name="d'Enfert C."/>
                <person name="Latge J.P."/>
                <person name="Mouyna I."/>
            </authorList>
            <dbReference type="PubMed" id="23508952"/>
            <dbReference type="DOI" id="10.1074/jbc.M112.440172"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 8 12">Cell surface beta-glucosidase involved in cytokinesis, cell wall biogenesis, adhesion to host tissue, and biofilm formation; thus playing an important role in the host-pathogen interaction. Has hydrolytic activity on linear (1-&gt;3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="12">Optimum pH is 5.5.</text>
        </phDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Secreted</location>
            <location evidence="11">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7 10">Secreted</location>
        </subcellularLocation>
        <text evidence="7 10">Secreted into the medium of cells growing as blastospores as well as those forming hyphae (PubMed:17905924). Secretion is decreased in cells lacking VPS4 (PubMed:19819358).</text>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5 9">Strongly up-regulated under hypoxic conditions and in white but not opaque cells (PubMed:16854431, PubMed:19798425). Repressed by exposure to caspofungin (PubMed:15917516). Expression is probably regulated by EFG1 since SUN41 has 9 E-boxes in its promoter (PubMed:12492856).</text>
    </comment>
    <comment type="PTM">
        <text evidence="15">Predicted to be a substrate for cleavage by KEX2.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6 7 8">Leads to increased cell size, cytokinesis defects, altered sensitivity to the cell wall-modifying substance Congo red, defects in adhesion, and reduced biofilm formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711315.2">
        <property type="nucleotide sequence ID" value="XM_706223.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NP5"/>
    <dbReference type="BioGRID" id="1230112">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59NP5">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59NP5"/>
    <dbReference type="CAZy" id="GH132">
        <property type="family name" value="Glycoside Hydrolase Family 132"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q59NP5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_00820W_A-T">
        <property type="protein sequence ID" value="C6_00820W_A-T-p1"/>
        <property type="gene ID" value="C6_00820W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647067"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600820WA"/>
    <dbReference type="CGD" id="CAL0000175157">
        <property type="gene designation" value="SUN41"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00820W_A"/>
    <dbReference type="HOGENOM" id="CLU_033459_2_0_1"/>
    <dbReference type="InParanoid" id="Q59NP5"/>
    <dbReference type="OMA" id="CSYACQS"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="PRO" id="PR:Q59NP5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044407">
        <property type="term" value="P:single-species biofilm formation in or on host organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000425079" description="Secreted beta-glucosidase SUN41">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12492856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15917516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16854431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17873081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="17905924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="18001349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="19798425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="19819358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="21622905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="23508952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="13">
        <source>
            <dbReference type="PubMed" id="12492856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="14"/>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="12419804"/>
        </source>
    </evidence>
    <sequence length="418" mass="43693" checksum="50A64905AD1E7B5A" modified="2017-03-15" version="2" precursor="true">MRFSQATVLAFAALSLAAPAFEADNKNIKREDCDKTSFHGHHKHKRAVAYDYAYVTVTVDGNGNPITTVSPVLSIETIAKSEETSSTSTSISSTTTIVQNDSLTSDEPKTLSLPSGTIKPSSFATESQSQSQSSSTGGSGSGSTNGIEGDLAAFEDPTEEFEDGVLSCSDFPSGQGVIPLDHLGFGGWSGIENSDGSTGGNCKEGSYCSYACQSGMSKTQWPEDQPSNGVSIGGLLCKNGKLYKSSTRSNYLCEWGVKKANVVNKLSETVAICRTDYPGTENMVIPTVVGGGSTSVITVVDQSTYYTWRGGATSAQYYVNNAGVSWEDGCVWGTPGSGVGNWAPLNFGAGYANGIAYLSLIPNPNNRDSLNFKVKIVGESGSTVSGSCSYANGKFNGNSDDGCTVGVTSGEADFVLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P92</accession>
    <name>Q59P92_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C404250WA</name>
        <name evidence="6" type="ordered locus">orf19.9000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711552.1">
        <property type="nucleotide sequence ID" value="XM_706460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P92"/>
    <dbReference type="FunCoup" id="Q59P92">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59P92"/>
    <dbReference type="GeneID" id="3646855"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404250WA"/>
    <dbReference type="CGD" id="CAL0000193728">
        <property type="gene designation" value="orf19.9000"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04250W_A"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_0_1_1"/>
    <dbReference type="InParanoid" id="Q59P92"/>
    <dbReference type="OMA" id="WGLICTG"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF166">
        <property type="entry name" value="ADR278WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000193728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="62688" checksum="6F263B9E0513215A" modified="2005-04-26" version="1">MSTLPFINNGNKSNTGSSHLPGRLTALIVSILVALASGTPYLYGVYSPQFVKQVGLTTSDSATISLATNLGSGVGGLPGGLIIDHFGPQKSILLGSVCIFIGYFAMHKIYEAKYDNLLIICLAMVLAGFGSITSYFATLKASQSNFPKHRGAAGAFPVSAYGFAATIFSIISATYFKGNSGGLLEFLSIFCGSMTFLGSFFIHIYLDHHDDREMDPEMSSPEFVSSPSPNYYNIESASSRSPRIEEEISLLSEGNSVIEPPATTMSRQDSLQGSISFWGIGQRTPRESISLQESEANNIVESLRNENVPKQQQEEQSKDSNKSWLNLISVPEFLQKENGRIFAIHYYIVSLASGIGQMYIYSVGFIVTAQYYYGKNKIENLTTENHRFSRNDIHHDPNVDDTVQTLQALQVSVISIASFSGRLFSGFLSDYIYKKWHIQRLWIVPVTLVFLALGQYLTIQNVNDLHLVTLASALIGGSYGLIFGTYPAVIADRFGTRSFSTSWGLVCTGPLITLWILNKSFGKLYDANSDSDTGICYLGNGCYQGAFELSLVLCGMTFVVTLLLIYIQRKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Q39</accession>
    <accession>A0A1D8PHS2</accession>
    <name>TRM10_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m1G9)-methyltransferase</fullName>
            <shortName evidence="2">tRNA(m1G9)MTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRM10</name>
        <name type="ordered locus">CAALFM_C206480WA</name>
        <name type="ORF">CaO19.25</name>
        <name type="ORF">CaO19.7696</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711832.1">
        <property type="nucleotide sequence ID" value="XM_706740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Q39"/>
    <dbReference type="SMR" id="Q59Q39"/>
    <dbReference type="FunCoup" id="Q59Q39">
        <property type="interactions" value="801"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Q39"/>
    <dbReference type="EnsemblFungi" id="C2_06480W_A-T">
        <property type="protein sequence ID" value="C2_06480W_A-T-p1"/>
        <property type="gene ID" value="C2_06480W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646568"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206480WA"/>
    <dbReference type="CGD" id="CAL0000179584">
        <property type="gene designation" value="orf19.7696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06480W_A"/>
    <dbReference type="eggNOG" id="KOG2967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034384_1_0_1"/>
    <dbReference type="InParanoid" id="Q59Q39"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="PRO" id="PR:Q59Q39"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000004">
        <property type="entry name" value="tRNA (guanine(9)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016653">
        <property type="entry name" value="TRM10/TRM10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016323">
        <property type="entry name" value="tRNA_m1G_mtfrase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <begin position="1"/>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <source>
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</entry>
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            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
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        <name evidence="10" type="ordered locus">CAALFM_C400700CA</name>
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    <reference evidence="10 11" key="1">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="15123810"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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        </reaction>
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            <name>Mg(2+)</name>
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        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
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        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase_6"/>
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    </dbReference>
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        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000193109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="321" mass="36121" checksum="4A19ED16FF11F967" modified="2005-04-26" version="1">MTIKPNPKHISSKQEAERILSKYDNFLFDCDGVIWLDEDLIPGVDKFLEWLTKNNKKFAFVSNNSSKSRNAYLKKFENLNIPNITKEILYPTCYSAALELQKLNIPKGSKIWVLGHEGIVDELRDMGYLPLGGNDKLLDEAFDHQNPILTVDPEVKAVVVGSTKEFNYMRIASTLQYLLHDHKSLPFIGCNIDRTYPGPKGLILPAGGSIVNYMSYTSNRDFINVGKPSKQFLDIILEDQKFDRSKTLMVGDTLYTDIKFGNDGNLGGDEENGGTLLVLSGGTKKKDLSHLLHNRHECKDSESLVPSYFVESLGKLIDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TT9</accession>
    <name>Q59TT9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DPP2</name>
        <name evidence="9" type="ordered locus">CAALFM_C111640CA</name>
        <name evidence="8" type="ordered locus">orf19.8747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713022.1">
        <property type="nucleotide sequence ID" value="XM_707929.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TT9"/>
    <dbReference type="STRING" id="237561.Q59TT9"/>
    <dbReference type="GeneID" id="3645341"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111640CA"/>
    <dbReference type="CGD" id="CAL0000185564">
        <property type="gene designation" value="DPP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11640C_A"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="InParanoid" id="Q59TT9"/>
    <dbReference type="OMA" id="HDLCQVT"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000185564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="284" mass="31941" checksum="1B4F5D3CEB42A093" modified="2005-04-26" version="1">MTFLNPSSIVKYTQSNQFHDFIPDWIVATVTVLFFFSVAETALPFQRQFSLDDLTISHPFAIKERVSGILCIEIAAFVPLFVILTSLLVKYQQGAFSSHQQALHCLQISVLGLIISLSLNGVITDILKIWIARPRPDFLERCGPAPGTPLHELVDVNVCTAPLGKALLIDGMKSTPSGHSSISFGGLFYLTLWLLGQFKLFQNRESPQYVYKYFLAFSPLSLATYIALSRTQDYRHHFTDIVLGGAIGISFAWWSYHHYFNKLVSEESHKPIDSETLTESLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UG9</accession>
    <name>Q59UG9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">IME2</name>
        <name evidence="7" type="ordered locus">CAALFM_CR03290CA</name>
        <name evidence="6" type="ordered locus">orf19.9931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713228.1">
        <property type="nucleotide sequence ID" value="XM_708135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UG9"/>
    <dbReference type="SMR" id="Q59UG9"/>
    <dbReference type="FunCoup" id="Q59UG9">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59UG9"/>
    <dbReference type="PeptideAtlas" id="Q59UG9"/>
    <dbReference type="GeneID" id="3645099"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03290CA"/>
    <dbReference type="CGD" id="CAL0000192224">
        <property type="gene designation" value="IME2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03290C_A"/>
    <dbReference type="eggNOG" id="KOG0661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_176_2_1"/>
    <dbReference type="InParanoid" id="Q59UG9"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040020">
        <property type="term" value="P:regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000192224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW31067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="520" mass="59082" checksum="9689B14FF64E5D9D" modified="2005-04-26" version="1">MSRHHSFPLDYDSPPKHLTVHSYHSKYQTISSLGNGSFGTVDLAKIKFFKFDLLNSHKNKSGTLLCPLEDSKCNTSNLVAIKTMKKKLPLLQEYSNVKEVKFILSVPSHPCLVQIYEMFIDDIQYQLHISMEALNQNLYQLIRSRRNIKFSPVTLKSILSQLLCAIRHIHKCNYFHRDVKPENILVIPTLHFYGSKAAIPPYRKNDNFIIKLGDYGLARHVSNIKPYTAYVSTRWYRSPEILLRQKWYSRPIDIWAFGAVAVETANFVPLFPGSNELDQIWKILKILGTPFVPEPKAINASYVVPLGGYWTEALFLTNKLGIKLPDESGMSIEDIVQHPDSLALIEVIQSCLKWDPSARADATEIAKMQYFKESITMMDTYFETDTVSMNTALNKLAGIPNSPSRKLLTPSKLQKNSNGTCNTTGSVPVFQDSDDGYENYFGEYIAKQPERNSSGNESYKLFAQPWLLKVNEVLGTRESEMEPRRAGNEAHDLKKKSSKVAGTKRSFTTFSLDSEEVVNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-06-18" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VM4</accession>
    <accession>A0A1D8PD90</accession>
    <name>RPN4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator RPN4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN4</name>
        <name type="ordered locus">CAALFM_C104330WA</name>
        <name type="ORF">CaO19.1069</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="PLoS Biol." volume="2" first="E398" last="E398">
            <title>Conservation and evolution of cis-regulatory systems in ascomycete fungi.</title>
            <authorList>
                <person name="Gasch A.P."/>
                <person name="Moses A.M."/>
                <person name="Chiang D.Y."/>
                <person name="Fraser H.B."/>
                <person name="Berardini M."/>
                <person name="Eisen M.B."/>
            </authorList>
            <dbReference type="PubMed" id="15534694"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.0020398"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="1018" last="1032">
            <title>Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Enjalbert B."/>
                <person name="Smith D.A."/>
                <person name="Cornell M.J."/>
                <person name="Alam I."/>
                <person name="Nicholls S."/>
                <person name="Brown A.J.P."/>
                <person name="Quinn J."/>
            </authorList>
            <dbReference type="PubMed" id="16339080"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-06-0501"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcriptional activator of a number of genes encoding proteasomal subunits. Binds to the DNA sequence 5'-GAAGGCAAAA-3', enriched in regions upstream of proteasome genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5 6 7">Expression is induced by HAP43, by osmotic stress, by oxidative stress, by heavy metal stress, and during biofilm formation.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713673.1">
        <property type="nucleotide sequence ID" value="XM_708580.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VM4"/>
    <dbReference type="FunCoup" id="Q59VM4">
        <property type="interactions" value="3521"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VM4"/>
    <dbReference type="EnsemblFungi" id="C1_04330W_A-T">
        <property type="protein sequence ID" value="C1_04330W_A-T-p1"/>
        <property type="gene ID" value="C1_04330W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644684"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104330WA"/>
    <dbReference type="CGD" id="CAL0000195107">
        <property type="gene designation" value="RPN4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04330W_A"/>
    <dbReference type="eggNOG" id="ENOG502RBAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024993_0_0_1"/>
    <dbReference type="InParanoid" id="Q59VM4"/>
    <dbReference type="OMA" id="ICEGRAN"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000426064" description="Transcriptional regulator RPN4">
        <location>
            <begin position="1"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type" evidence="2">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15534694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16339080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <sequence length="536" mass="60153" checksum="FCB82332A4C8F715" modified="2005-04-26" version="1">MTSLAILPQLKRTITDIMDEELYQSPSSPNSMTSFPSGTGNLMSNTNHNTFNQSNNTPFNMNYNHISNRNSINSSPNLSATTFNNANNLGNVLNIPDSFLEQLASQDYIDHLKSQQQQEQAFENPDDIYVQDVHENQVNPFNDYGNPDSFIRAQEQQSQLPQPQQPISQQDKQRPQSQQQQATKAPLPQAFPTRRRRKITLLNDIGGSSTRKKHFDEDYLLYNPDISPGHIVTDCSLDSSLVIPPNSNELFLTESESPEFANDIIPGYENDYLFLDDDDEQIEEDVSDDEGDNYFQVDEDFDDYLMNNNGYDGYPTFNNYESSGNNTDIINNNNNIVDETISDANSNSELEVVFDQPKEVSPSAISPASPDSDDMMIDVEDETEIADATAAKEEINKKHSKSGKKESKSQKENQLTTTTKSKKHSHGISGAEITLNNPNHQCNLINPSTGEPCNKQFSRPYDLIRHQDTIHASMKKIFRCVICEGRLNGGPGNGKEKTFSRGDALSRHIKIKHGLVGQDALDLINEAKENVEYIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q59W48</accession>
    <name>Q59W48_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Microtubule-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C111250WA</name>
        <name evidence="13" type="ordered locus">orf19.8293</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713809.1">
        <property type="nucleotide sequence ID" value="XM_708716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59W48"/>
    <dbReference type="SMR" id="Q59W48"/>
    <dbReference type="FunCoup" id="Q59W48">
        <property type="interactions" value="732"/>
    </dbReference>
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    <dbReference type="GeneID" id="3644556"/>
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        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
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        <property type="entry name" value="CH"/>
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        <property type="entry name" value="EB1_C"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="4"/>
            <end position="105"/>
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        <location>
            <begin position="221"/>
            <end position="297"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="175"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="135"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="155"/>
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    </evidence>
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    </evidence>
    <sequence length="298" mass="32419" checksum="FB07FF8785C36ADE" modified="2005-04-26" version="1">MVVGESRAELLNWLNSTLGLNYTKIEQCGSGAAFCQLMDTIVGDVPLSKVKFNAKTEYEFRHNYKILQHVFVKNSITKTIDVEKLIRCKLQDNLELLQWIKRYASSNNVPMKTTVARQPPKQTTKPTTSSPGSSPINAGPSAAPLISKPRERKSNTPIGSRKTSSNGPINLTPTAVRSTNIAASKNNNRSGNGTIVNNGHVGAVSASEPEAVDAAAVGAAAAAAAPIDSGATSSIPEDFAIYSQHVESERDFYFNKLRAIEILVQHAKEMEGLSGDVLQFANEIEKIMYEEYVEDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WB7</accession>
    <name>Q59WB7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">RIA1</name>
        <name evidence="13" type="ordered locus">CAALFM_C107140CA</name>
        <name evidence="12" type="ordered locus">orf19.11931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_708802.1"/>
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    <dbReference type="InParanoid" id="Q59WB7"/>
    <dbReference type="OMA" id="FARCDIQ"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF2"/>
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        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Elongation factor like GTPase 1"/>
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    </dbReference>
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        <property type="entry name" value="Ribosome assembly protein 1"/>
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        <property type="entry name" value="Translation elongation factor 2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
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        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000176174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW26366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117839" checksum="3846BCD02674D515" modified="2005-04-26" version="1">MKISPETVNKLQSDASCIRNICILAHVDHGKTSLSDSLLATNGIISQRMAGKVRYLDSREDEQLRGITMESSAISLYFKVMRLQQGSQEPEVHEHLINLIDSPGHIDFSSEVSTSSRLCDGAVVLVDVVEGVCSQTVNVLRQCWIDKLKPLLVINKIDRLITEWKLSPLEAYQHISRIIEQVNSVIGSFFAGDRLEDDLNWREAGSVGEFIEKSDEDLYFTPEKNNVIFASAIDGWAFSVNTFAKIYSKKLGFSQQALSKTLWGDFYLDMKNKKIIPGKKLKNNSNSLKPLFVSLILDQVWAVYENCVIERNQDKLEKIIEKLGAKITPRDLRSKDYKNLLNLIMSQWIPLSHAILGSVIEYLPSPIVAQRERIDKILDETIYSAVDSESDKSKLVDPSFVKAMQECDSSHPETHTIAYVSKLLSIPNEDLPKASNAATGGLTADEIQERGRIARELAKKASEAAALAQEGSKNEDEFAIKPKKDPFEWEFEEDDFENEEDESDANAVEESTETIVGFTRIYSGSLSRGQKLTVIGPKYDPSLPRDHQTNFEQITNEVEIKDLFLIMGRELVRMEKVPAGNIVGVVGLDNAVLKNATICSPLPEDKPYINLASTSTLIHNKPIMKIAVEPTNPIKLAKLERGLDLLAKADPVLEWYVDDESGELIVCVAGELHLERCLKDLEERFAKGCEVTVKEPVIPFREGLADDKISTNTNNNNDDNEDHELDENEDELADLEFDISPLPLEVTQFLIENETIIAEIVNNKQDTHEIRNDFIEKFATIIDNSNLATQFPDTKSFINNIICFGPKRVGPNIFIEDYGLNKFRHLLGESATESRFVYENNVFNGVQLVFNGGPLASEPMQGIIVRLKKAEKREVDEDKIVNPGKIITQTRDLIYKRFLQKSPRLFLAMYTCEIQAAAEVLGKVYAVVQRREGSIISEEMKEGTPFFTIVARIPVIEAFGFSEDIRKKTSGAASPQLVFDGYDMLDIDPFWVPHTEEELEELGEFAERENVARRYMNNIRRRKGLFVDEKVVKNAEKQRTLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YG6</accession>
    <name>Q59YG6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C209920WA</name>
        <name evidence="6" type="ordered locus">orf19.8940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714534.1">
        <property type="nucleotide sequence ID" value="XM_709441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YG6"/>
    <dbReference type="SMR" id="Q59YG6"/>
    <dbReference type="STRING" id="237561.Q59YG6"/>
    <dbReference type="GeneID" id="3643776"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209920WA"/>
    <dbReference type="CGD" id="CAL0000184716">
        <property type="gene designation" value="orf19.8940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09920W_A"/>
    <dbReference type="eggNOG" id="ENOG502S7IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1635146_0_0_1"/>
    <dbReference type="InParanoid" id="Q59YG6"/>
    <dbReference type="OMA" id="WYSCYST"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000184716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="162" mass="19002" checksum="14A8B7FAC76C0ADD" modified="2005-04-26" version="1">MIKQLLISPSCKILPTNRFIYNWYSCYSTNKPRKSIESNQKKSTTTTTFTPTPTSTSTSSSQSQSPTTDQILFEQFQKSVIKNDIKHNPNNQPFWMKRNRTIKSKHSHWNPTKKLSRSEMNKLRELKQYFPHFTTADLGKIFHISPESVRRILKSKYIPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZZ8</accession>
    <name>Q59ZZ8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR03470WA</name>
        <name evidence="2" type="ordered locus">orf19.11868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715166.1">
        <property type="nucleotide sequence ID" value="XM_710073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZZ8"/>
    <dbReference type="GeneID" id="3643198"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03470WA"/>
    <dbReference type="CGD" id="CAL0000199054">
        <property type="gene designation" value="orf19.11868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03470W_A"/>
    <dbReference type="eggNOG" id="ENOG502SRSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542928_0_0_1"/>
    <dbReference type="InParanoid" id="Q59ZZ8"/>
    <dbReference type="OrthoDB" id="4093447at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="499" mass="54855" checksum="5B5232025D81F4F4" modified="2005-04-26" version="1">MINKNLNLSLKLNKLDFVPPNSNFGGSSSPFTPVDQTLKTPLEAPQHQTEFPLQHQFQSQQQGYHGNVNQSSLYQNPEVNESDDILTDIDEPCNLTRRNFTLFFTNQFDQVLISIYSTILSLPTTTPFSGNIPPSGLVSKVANETIKELIRVTSASKNTPIYDQFNIINSDCLRSHEYQPIILQLIRKRLLEICHSKNNSVNKLPESTSISLNSTVTRNSSVSNLSLSDMNLMNYNNSNQNNTAVNLARSRSSSINLRKQSLTRNNSNNWLHVGNINNLRPSGNPDFNMSTDSLQSFQDFVPQSIINRTSNGSGNANVTNNSNNLVSSSSNVGQLNSMMMDYHITPPTSHKGSISSTNSPYNIVHNPCTSDSEEFQFLQRSRSSSRGNNLPQALNINTDMSNLQALNSLQGNSGNSKYVQPGLSLDSPFLSATTPGDEYFSGPSFANPSNNSTTAVISAGSNSVENAEAGGDTSKANLPNQYSLSEKKRDSLKMKRGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A006</accession>
    <name>Q5A006_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_CR03600CA</name>
        <name evidence="14" type="ordered locus">orf19.11860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715158.1">
        <property type="nucleotide sequence ID" value="XM_710065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A006"/>
    <dbReference type="SMR" id="Q5A006"/>
    <dbReference type="FunCoup" id="Q5A006">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A006"/>
    <dbReference type="GeneID" id="3643207"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03600CA"/>
    <dbReference type="CGD" id="CAL0000177111">
        <property type="gene designation" value="orf19.11860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03600C_A"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A006"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000045">
        <property type="entry name" value="Vesicle coat complex COPI, zeta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000177111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW31098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="200" mass="22662" checksum="F2179CFAEEF62248" modified="2005-04-26" version="1">MSLNISLYTISAVLILDNEGNRLFAKYYKSSLGEDSANPSSKFPHQFDTQQQQLNFEKSLFSKTYKVNQDILLYDNHLIAYKQTNDLLLYLVAPLNENESLIYSTMNNLFEALTILLDNTVDKQTILDKYDMVCLAIDETIDDGIIIEYDPATIVSRVTNPPSAVYENVNLKNIDISEKGLFNALSFASKKLGERLQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A017</accession>
    <name>Q5A017_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transaldolase</fullName>
            <ecNumber evidence="4 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">TAL1</name>
        <name evidence="12" type="ordered locus">CAALFM_CR03720WA</name>
        <name evidence="11" type="ordered locus">orf19.11849</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715147.1">
        <property type="nucleotide sequence ID" value="XM_710054.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A017"/>
    <dbReference type="SMR" id="Q5A017"/>
    <dbReference type="FunCoup" id="Q5A017">
        <property type="interactions" value="723"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A017"/>
    <dbReference type="GeneID" id="3643225"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03720WA"/>
    <dbReference type="CGD" id="CAL0000194226">
        <property type="gene designation" value="TAL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03720W_A"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A017"/>
    <dbReference type="OMA" id="FATIKKY"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000194226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="323" mass="35672" checksum="0BD1C1D02F5BFDE5" modified="2005-04-26" version="1">MSSNSLEQLKATGTTIVTDTGEFEQIAKYKPQDATTNPSLILAATKNPEYASVIDVAIEYAKDKGSSPKEKAEIALDRLLIEFGKNILDIVPGRVSTEVDARLSFDKEATVKKALELIDLYKQQGIEKDRILIKIASTWEGIQAARELESKHGIHCNLTLLFSFAQAVACAEAGVTLISPFVGRILDWYKASTGEEYTAETDPGVQSVKAIYNYYKKYGYKTIVMGASFRNTGEIKALAGCDFLTISPKLLEQLYNSTEEVPKQLDAATAKDEDVEKVTYVDDESAFRFALNEDAMATEKLSQGIRQFGKDAVTLLTELESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0X6</accession>
    <name>Q5A0X6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C406910WA</name>
        <name evidence="11" type="ordered locus">orf19.10632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715429.1">
        <property type="nucleotide sequence ID" value="XM_710336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0X6"/>
    <dbReference type="SMR" id="Q5A0X6"/>
    <dbReference type="STRING" id="237561.Q5A0X6"/>
    <dbReference type="GeneID" id="3642933"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406910WA"/>
    <dbReference type="CGD" id="CAL0000177033">
        <property type="gene designation" value="orf19.10632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06910W_A"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="InParanoid" id="Q5A0X6"/>
    <dbReference type="OMA" id="FWYYTFY"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000177033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW29412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="579" mass="64681" checksum="A5EEC2B6E2361011" modified="2005-04-26" version="1">MSVETYSWSNISLTLQNGKTILDDIYGSVSAGEMLAIMGPSGCGKSTLLNVLAYRTSPRSSTLEGGIFINNERATLNKIKQLSSYVEQEDSLIGSLTVSETVDYSAQFAGIDKAHKKELVSKTIKSLGLEGQAMSKIGTPIQKGISGGQKRRVSIASQIITSPSILFLDEPTSGLDSVASREVISTIKKIAKRENMVIICSIHQPSTYTFELFDKVMFLSKGRTVYNGAVSNVVKYFNSIGHTMPPYINPAEYVLDLINTDFQGDSSVLDDLVSKWNSGDVHKVGTESVQLTEATTINEMQNILILIARSLTKARRDILTYYVRLVMYLGLAILMGTVWLRLQNGQKNIQPFINAIFFSGAFMSFMSVAYIPSYLEDIQSYKKERMNGLYGPLAFSLANFLVGLPFLFLIAAVFSVITFFMVNFHQTASGFWYYLMWLFLDLVAAESMTTFIASVFPNFVVSLAITAFANGLWMAVGGFLVPSNILNVFWYYTFYWIDYQRYVFQGMIFNEFTNREFRCGDGCHCMYDSPLASQCKISGKAVLESLGYGNYDKGLWIGVLIALVFVYRFATYIVLKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1Z1</accession>
    <name>Q5A1Z1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial 37S ribosomal protein MRP21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRP21</name>
        <name evidence="5" type="ordered locus">CAALFM_CR02950CA</name>
        <name evidence="4" type="ordered locus">orf19.10371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715783.1">
        <property type="nucleotide sequence ID" value="XM_710690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1Z1"/>
    <dbReference type="SMR" id="Q5A1Z1"/>
    <dbReference type="FunCoup" id="Q5A1Z1">
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    <dbReference type="KEGG" id="cal:CAALFM_CR02950CA"/>
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        <property type="gene designation" value="MRP21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02950C_A"/>
    <dbReference type="eggNOG" id="ENOG502SYGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119637_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A1Z1"/>
    <dbReference type="OMA" id="YIRPAKY"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
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    </dbReference>
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        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000192450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="193" mass="22567" checksum="7FE1BFE6F6A93BCE" modified="2005-04-26" version="1">MMKSILGSGLINNIAKSSLNKSVLRPSYTPIRFNSNNANLDQLKSIFNQLNEKSTTTNDSQTKSTLNIDDLLSNSILETRERPQSNSFGVYDKFGFEQTRQPTPREVAKNIREFGVNAGRTVDVSYNNISRSFAQVKRVVNDNKIRYLQRIQSRFIRPAKYRKQLKREWWRRRFSQGFKELLHDVNDARRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A2U7</accession>
    <name>Q5A2U7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Steryl deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C208170WA</name>
        <name evidence="2" type="ordered locus">orf19.9714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716009.1">
        <property type="nucleotide sequence ID" value="XM_710916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A2U7"/>
    <dbReference type="SMR" id="Q5A2U7"/>
    <dbReference type="ESTHER" id="canal-q5a2u7">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="3642318"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208170WA"/>
    <dbReference type="CGD" id="CAL0000190525">
        <property type="gene designation" value="orf19.9714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08170W_A"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053543_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A2U7"/>
    <dbReference type="OMA" id="IMISLRA"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
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        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000190525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="447" mass="50769" checksum="D587527B46AF9F54" modified="2005-04-26" version="1">MGHLEYKLIEICLQFQYQLIKTSIEFIKTLSTLFIMISLRAVIALILLPLNLLFVLIKYPFFGGVNPIYKNDLVNSLKLTVYQALINFPLDDVHIFSIISAEFVINKAVGKLYPGLTSKLPNYGKKFDKQSFWLVEKPNRKPDDPVLIYLHGGGYFLGLVPQQIESLVTTYHLLDPVKRENLSILVLDYNLTCQGYPIPHQLSQLVETYTNLVKEGGKNFLLMGDSAGGNLAITFTQYLRLSNSSNLPYPKSSILISPWVKLIAETYQNTPGHSYYNYSSGDVTQYDTLSGAEVYQHILGTETKLNSLTVSPGNCPYDSKDWQDIPTYNQPGHSVFVLAGEHETFRDDILEWSKYALNYPLDELDFQDSNGEFNPKVHKYIRNDENSAYIDVTIVPWGAHDFLFFEHTLIGKLKSEPSLKLQSINKRKYFGTTSVVNFLNTVLPGEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A2Y7</accession>
    <accession>A0A1D8PKJ6</accession>
    <name>NSA2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Ribosome biogenesis protein NSA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NSA2</name>
        <name type="ordered locus">CAALFM_C306380WA</name>
        <name type="ORF">CaO19.7424</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716088.1">
        <property type="nucleotide sequence ID" value="XM_710995.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716639.2">
        <property type="nucleotide sequence ID" value="XM_711546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A2Y7"/>
    <dbReference type="SMR" id="Q5A2Y7"/>
    <dbReference type="BioGRID" id="1225353">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A2Y7">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A2Y7"/>
    <dbReference type="EnsemblFungi" id="C3_06160C_A-T">
        <property type="protein sequence ID" value="C3_06160C_A-T-p1"/>
        <property type="gene ID" value="C3_06160C_A"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_06380W_A-T">
        <property type="protein sequence ID" value="C3_06380W_A-T-p1"/>
        <property type="gene ID" value="C3_06380W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642259"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306160CA"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306380WA"/>
    <dbReference type="CGD" id="CAL0000197650">
        <property type="gene designation" value="NSA2"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000192673">
        <property type="gene designation" value="orf19.7397.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06160C_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06380W_A"/>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A2Y7"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000320412" description="Ribosome biogenesis protein NSA2">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal 1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal 2" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="261" mass="29578" checksum="3386DFB1E4F2BD82" modified="2005-04-26" version="1">MPQNEYIEQHIKKHGRRLDYEERKRKKEAREGHRVAKDAQTLKGWRAKQFAKKRYAEKVAMKKKIKAHQESKVKGPSTPKAEDGEALPTYLLDRQTNNTAKAISSSIKQKRLEKADKFQVPLPKVKGISEEEMFKVIKTGKSKSKSWKRMITKHTFVGEGFTRRPVKMERIIRPAALRQKKANVTHPELGVTVFLPILGVKKNPQSPMYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGKYAQITNEPDRDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3K7</accession>
    <name>Q5A3K7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">SER33</name>
        <name evidence="17" type="ordered locus">CAALFM_C112030WA</name>
        <name evidence="16" type="ordered locus">orf19.12728</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716332.1">
        <property type="nucleotide sequence ID" value="XM_711239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3K7"/>
    <dbReference type="SMR" id="Q5A3K7"/>
    <dbReference type="FunCoup" id="Q5A3K7">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A3K7"/>
    <dbReference type="GeneID" id="3642030"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112030WA"/>
    <dbReference type="CGD" id="CAL0000190003">
        <property type="gene designation" value="SER33"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12030W_A"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_1"/>
    <dbReference type="InParanoid" id="Q5A3K7"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="393"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000190003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW26822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="463" mass="50359" checksum="DF920EBEB466C6E6" modified="2005-04-26" version="1">MSSPQQIVNSFQQALNLSGSPNAVSTSPTQSFLSQYVPSKPAKALKPFKTGDIKILLLENVNQTAINIFKNQGYQVEFYKSSLPEDELLEKIKDVHAIGIRSKTKLTEKILKAAKNLVVIGCFCIGTNQVDLEFAAKSGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAKCWEIRGKTLGIVGYGHIGSQLSVLAEAMGMNVIYYDVMTIMSLGNSKQVESLDELLKKADFVTLHVPATPETKNLLSAPQFAAMKDGAYVINASRGTVVDIPALVQAMKAGKIAGAALDVYPHEPAKNGEGLFSDSLNEWASELCSLRNVILTPHIGGSTEEAQSAIGIEVGNSLTKYINEGASQGAVNFPEVSLRPLDLDQQNVVRVLYIHQNVPGVLKTVNNILSNHNIEKQFSDSQGDIAYLMADISDVDISDIQSLYEQLEQTPYKIATRLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6M9</accession>
    <name>Q5A6M9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">NHP2</name>
        <name evidence="12" type="ordered locus">CAALFM_CR04360CA</name>
        <name evidence="11" type="ordered locus">orf19.8159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717389.1">
        <property type="nucleotide sequence ID" value="XM_712296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6M9"/>
    <dbReference type="SMR" id="Q5A6M9"/>
    <dbReference type="FunCoup" id="Q5A6M9">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6M9"/>
    <dbReference type="GeneID" id="3641003"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04360CA"/>
    <dbReference type="CGD" id="CAL0000183079">
        <property type="gene designation" value="NHP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04360C_A"/>
    <dbReference type="eggNOG" id="KOG3167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A6M9"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000015">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit NHP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000183079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="159" mass="17166" checksum="DD78B2FDD669A64C" modified="2005-04-26" version="1">MGSKKESKSKSSSDDVSTEDNYEKRMSAVLPFAKPLASKKLNKKILKTVKKASKAKHVKRGVKEVVKSLRKGEKGLVIIAGDISPADVISHIPVLCEDNSVAYIFIPSKEDLGSAGATKRPTSCVMIVPGGGKSKKNADKTDEYRDGFDDIVKEINASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A864</accession>
    <name>Q5A864_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cruciform cutting endonuclease 1, mitochondrial</fullName>
            <ecNumber evidence="11">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">CCE1</name>
        <name evidence="15" type="ordered locus">CAALFM_CR00920WA</name>
        <name evidence="14" type="ordered locus">orf19.10774</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717954.1">
        <property type="nucleotide sequence ID" value="XM_712861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A864"/>
    <dbReference type="SMR" id="Q5A864"/>
    <dbReference type="FunCoup" id="Q5A864">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A864"/>
    <dbReference type="GeneID" id="3640395"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00920WA"/>
    <dbReference type="CGD" id="CAL0000187718">
        <property type="gene designation" value="CCE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00920W_A"/>
    <dbReference type="eggNOG" id="ENOG502SDUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_880308_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A864"/>
    <dbReference type="OMA" id="YPQIVIP"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000160">
        <property type="entry name" value="Cruciform cutting endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="13">
        <location>
            <begin position="66"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000187718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW30857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="332" mass="38574" checksum="65CD10991E32BEC9" modified="2005-04-26" version="1">MIQKSYLIERLRSCKISTLNDLAILTGSPIISTNKSCRIEGLTAGYYFYLNHYHKFLSTQKQRTTLSIDVGIKNFSYCKSKSSKSTSSSTLTTSNFPIIITKWDKLNLDTQYGGDNYSSILHKDSILDNKRYLNQLTKSLVNELQPNEYDVVIMEIQRTRSAGNTSTLPTVLLNYTLENLIFGNIYPQIVIPMTSFKMTNFWLHRFITRSTTNTKQLKSNNNNKGIRFELMKLWLNKLFILPKYPQNELTKLDLLKYLKLDKSEKIDDLIDSLLYNLTINRQFQHLAEFHQLMVSNNGDIAQFVHDKNKYHLQLIQPIIDKYELELKPGSID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A869</accession>
    <accession>A0A1D8PRV3</accession>
    <name>SEC11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="1">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Signal peptidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SEC11</name>
        <name type="ordered locus">CAALFM_CR00990WA</name>
        <name type="ORF">CaO19.10769</name>
        <name type="ORF">CaO19.3259</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="1"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717949.1">
        <property type="nucleotide sequence ID" value="XM_712856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A869"/>
    <dbReference type="SMR" id="Q5A869"/>
    <dbReference type="FunCoup" id="Q5A869">
        <property type="interactions" value="708"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A869"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="EnsemblFungi" id="CR_00990W_A-T">
        <property type="protein sequence ID" value="CR_00990W_A-T-p1"/>
        <property type="gene ID" value="CR_00990W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640425"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00990WA"/>
    <dbReference type="CGD" id="CAL0000184794">
        <property type="gene designation" value="orf19.10769"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00990W_A"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A869"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="PRO" id="PR:Q5A869"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000412320" description="Signal peptidase complex catalytic subunit SEC11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal short (CTS) helix" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P67812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="166" mass="18867" checksum="9620CF24C3827A6D" modified="2005-04-26" version="1">MNIRQQITQFLSLAYVFSSAFMLWKTLSVIANSHSPIVVVLSGSMEPAFQRGDILFLWNRDHQQKVGDIVVYEIDGKSIPIVHRVLREHHNSEKQLLLTKGDNNAVDDLSLYAKKQQYLNQKQDLVGTVKGYLPFIGYVTILISENVYFKYGMLGLLGLSSLFSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A894</accession>
    <name>Q5A894_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oye22p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">OYE22</name>
        <name evidence="6" type="ordered locus">CAALFM_CR01200WA</name>
        <name evidence="5" type="ordered locus">orf19.10744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717925.1">
        <property type="nucleotide sequence ID" value="XM_712832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A894"/>
    <dbReference type="SMR" id="Q5A894"/>
    <dbReference type="STRING" id="237561.Q5A894"/>
    <dbReference type="GeneID" id="3640408"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01200WA"/>
    <dbReference type="CGD" id="CAL0000176070">
        <property type="gene designation" value="OYE22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01200W_A"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A894"/>
    <dbReference type="OMA" id="MMATYYK"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000337">
        <property type="entry name" value="NADPH dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000176070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="392" mass="43886" checksum="A65C0ACDB16AD454" modified="2005-04-26" version="1">MTISNSNLFKPINIGKKTISHRIAHLPTTRNRATKDHVPTDLMQKYYTDRAKTGGLLVTEATLISLNQGIYPNVPGIWNNQQRDAWKKITDSVHSVGGFISVQLWALGRVGNAKLLKNHGLPLTGVSPIYEHEQAEKDAVKAENPIQELTQDEIKDIIYNQFANAAKLADEAGFDFIELHGANGYLFEQFIHPGTNKRTDKYGGSIENRARFLFEVVDHLSTIVDPSKLAIRLSPLNNFQVPGINPTAKEDYSYIIAGLQKRADEGKGFGYINVVEGRFSPDGSTEACDVNFVGDIWKGALLKGGNYTYDKKNSWETIERDANADNRTLVGFGRYFIANPDLPTRIEKDLPLNDYDRSTFYANDDYGYNTYPFYGQEIKADPEHKVFGVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A896</accession>
    <name>Q5A896_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_CR01220WA</name>
        <name evidence="9" type="ordered locus">orf19.10742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717923.1">
        <property type="nucleotide sequence ID" value="XM_712830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A896"/>
    <dbReference type="SMR" id="Q5A896"/>
    <dbReference type="GeneID" id="3640406"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01220WA"/>
    <dbReference type="CGD" id="CAL0000199600">
        <property type="gene designation" value="orf19.10742"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01220W_A"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="Q5A896"/>
    <dbReference type="OMA" id="FMYLNGR"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="74"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000199600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="521" mass="57757" checksum="4D647665C0513680" modified="2005-04-26" version="1">MSTTKPTTSHVESDTKPDADHLEIRKSNLSESDLGVEEISDLKYINLPPSLQHMTQEELRTLDKKTTRKIDLRLMPMLIFIYILNYLDRNNLASARLGGLEKDIGLVGNQYQICISILFVGYILFQVPSNMLLNKMGRPSIYLSVVMTIWGAISTATGAVQSFGGLVAVRVLLGVVESAFFPGALMILSSWYDKKTLASRNSILYAGSLISSAFSGLIAAGILKMDGLGGVQGWRYLFIIEGGITVLTVPFAYFILPDNPSNTKFLSQEEKDIIMWKMKRDLGNVNDSDKEAQESEIQGFMHACKDIKVWLLCAIHSFLVAACGVTNFFPSVVQTLNFDRTTTLCLTAPPYVIAVVATYLWAKHADHSGERFYHVTIPLVLSLVAFIISAASLNTGARYFSMCLMIPSLYCAFVVILTWISNCCPRPPAKRAAAIAIVNCLSNSTSIWNAYLYPSSDAPRYLVAFCCNSAFIVLSILFAVGLRIRLTVLNKRIERGTMDWQKELGKGNDGSKISPDFRFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8I5</accession>
    <name>Q5A8I5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C603880WA</name>
        <name evidence="4" type="ordered locus">orf19.13186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718098.1">
        <property type="nucleotide sequence ID" value="XM_713005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8I5"/>
    <dbReference type="SMR" id="Q5A8I5"/>
    <dbReference type="STRING" id="237561.Q5A8I5"/>
    <dbReference type="GeneID" id="3640293"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603880WA"/>
    <dbReference type="CGD" id="CAL0000177286">
        <property type="gene designation" value="orf19.13186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03880W_A"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A8I5"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001330">
        <property type="entry name" value="Peroxisomal 2,4-dienoyl-CoA reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000177286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28695" checksum="2261CF0AA676977F" modified="2005-04-26" version="1">MSQLFSLNGQVAILTGGTNGIGLGYAKGLASADLDQLILTYRSESTLEKAKKIIHEVNPNVQIDGIKIDFLKDEEDEIITKIVEESYKLSKTSNIDILVNNAGITERYPFEDFPQDKFDDVIKVDLNIPVKLTKAIGKKMLETNTKGKIVFTASLLSFQGGMLSTPYAISKGALKQFTQAVSNEWSSRGIRVNSIAPGYIKTNLTDSMSEENKKIVDLRIPMKRWGNPDDFMGPIVYLTSDASKYVTGDTLLVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A905</accession>
    <name>Q5A905_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sphinganine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C101400CA</name>
        <name evidence="11" type="ordered locus">orf19.10839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Martchenko M."/>
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    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Chromosome</location>
            <location evidence="1 9">Centromere</location>
            <location evidence="1 9">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Associated with the kinetochore.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718187.1">
        <property type="nucleotide sequence ID" value="XM_713094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A9E6"/>
    <dbReference type="SMR" id="Q5A9E6"/>
    <dbReference type="FunCoup" id="Q5A9E6">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A9E6"/>
    <dbReference type="GeneID" id="3640167"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01360WA"/>
    <dbReference type="CGD" id="CAL0000195269">
        <property type="gene designation" value="NNF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01360W_A"/>
    <dbReference type="eggNOG" id="ENOG502RZTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117280_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A9E6"/>
    <dbReference type="OMA" id="SSCFPEY"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016851">
        <property type="entry name" value="Nnf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027153">
        <property type="entry name" value="Nnf1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000195269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="196" mass="22241" checksum="FF411AD21807B0AF" modified="2005-04-26" version="1">MSADENNKVRFERLRLVARKALEQSIKKSLTMEQVKTCFPTLVTSQDGVRSLELALSQMSGFWHANSLDEFDLIYKEKDIESKLDELDDIIQNAQRTKDSGKEPSNIDQLSPLEIVDSTIVSNSKNVLDSLQMIYDQLCLDNAELYTELSELTKESTRINNSIKSGIEQLNKEANSVELEKAGLQIDKLIDILEEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ACM4</accession>
    <accession>A0A1D8PU78</accession>
    <name>PNO1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PNO1</name>
        <name type="ordered locus">CAALFM_CR10410CA</name>
        <name type="ORF">CaO19.7618</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719379.1">
        <property type="nucleotide sequence ID" value="XM_714286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ACM4"/>
    <dbReference type="SMR" id="Q5ACM4"/>
    <dbReference type="FunCoup" id="Q5ACM4">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ACM4"/>
    <dbReference type="EnsemblFungi" id="CR_10410C_A-T">
        <property type="protein sequence ID" value="CR_10410C_A-T-p1"/>
        <property type="gene ID" value="CR_10410C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638957"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10410CA"/>
    <dbReference type="CGD" id="CAL0000173996">
        <property type="gene designation" value="orf19.7618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10410C_A"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="InParanoid" id="Q5ACM4"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000278365" description="Pre-rRNA-processing protein PNO1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="KH">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q99216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="276" mass="30652" checksum="4BB370DE82C15E97" modified="2005-04-26" version="1">MAAPTAIRKSTEKSGINEQIQENSTLQSNQALDQNNDDEDMLIDTNAIPTTTVEDQDQSEPSNSLTIQQGETTELQLDESGKPKFSAASKSNMKVKLESRKVAVPPHRMTPLKNVWSKIYPPLVEHLKLQVRMNLKTKTVELRTNKYTTDVGALQKGADFVKAFTLGFDVDDAIALLRLDDLYIETFEIKDVKTLTGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRMAREAVVSLILGSPPGKVYGNLRTVASRMKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD18</accession>
    <name>Q5AD18_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C200750WA</name>
        <name evidence="3" type="ordered locus">orf19.9597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721505.1">
        <property type="nucleotide sequence ID" value="XM_716412.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI45"/>
    <dbReference type="FunCoup" id="Q5AI45">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="GeneID" id="3636929"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103140WA"/>
    <dbReference type="CGD" id="CAL0000192366">
        <property type="gene designation" value="orf19.10525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03140W_A"/>
    <dbReference type="eggNOG" id="ENOG502S5Q7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141728_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AI45"/>
    <dbReference type="OMA" id="HFDMLDQ"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd24144">
        <property type="entry name" value="BLOC1_CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000192366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="158" mass="18586" checksum="2ADB12AE85A8C3AD" modified="2005-04-26" version="1">MSFDEGRNNSLDQVVSQDNTKDKDNHNDLLPQPSGQVSTSSPQKDNTPPSPTPSNDDPDPLELKKLSLNYDYLMYKIKDYINTLTEQTYQSILSKQYQINQEYLHDQLNLFDNYETIDEMLKTISQLEMEFLKLDQLEVFIEDFKQRLNVLEHEFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI79</accession>
    <accession>O94032</accession>
    <name>Q5AI79_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">YKT6</name>
        <name evidence="15" type="ordered locus">CAALFM_C102860CA</name>
        <name evidence="14" type="ordered locus">orf19.10491</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721473.1">
        <property type="nucleotide sequence ID" value="XM_716380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI79"/>
    <dbReference type="SMR" id="Q5AI79"/>
    <dbReference type="FunCoup" id="Q5AI79">
        <property type="interactions" value="1306"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AI79"/>
    <dbReference type="GeneID" id="3636863"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102860CA"/>
    <dbReference type="CGD" id="CAL0000191319">
        <property type="gene designation" value="YKT6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02860C_A"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AI79"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000020">
        <property type="entry name" value="Synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="12">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000191319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW25967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="200" mass="22864" checksum="6EF5BA85996F0033" modified="2005-04-26" version="1">MKIYYIGILRSSGDKALELTSARDLSQFSFFERNGVSQFMTFFAETVSQRTQPGQRQSVEEGNYIGHTYTRSEGISGIIITDKDYPVRPAYTLINKILEEYLSLHPKSDWENIDKANETLQYGQLEAYLKKYQDPTQADSIMKVQQELDDTKVVLHKTIEGVLQRGEKLDSLVDKSEALSSSSRMFYKQAKKTNSCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK30</accession>
    <name>Q5AK30_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C504990WA</name>
        <name evidence="8" type="ordered locus">orf19.11473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721898.1">
        <property type="nucleotide sequence ID" value="XM_716805.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK30"/>
    <dbReference type="SMR" id="Q5AK30"/>
    <dbReference type="FunCoup" id="Q5AK30">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK30"/>
    <dbReference type="GeneID" id="3636538"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504990WA"/>
    <dbReference type="CGD" id="CAL0000193163">
        <property type="gene designation" value="orf19.11473"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04990W_A"/>
    <dbReference type="eggNOG" id="KOG4168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092529_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AK30"/>
    <dbReference type="OMA" id="PTNMVHL"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000021">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000193163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="163" mass="19042" checksum="1A22DF5AA2FF2613" modified="2005-04-26" version="1">MKVLTERDSFLSNYEVLQHLQNIKKKYNWSFNPNDEKFMKNKKNKHHFTGCGINLEIITRDVLSCLENNESSLIQSTKSFKQLMEFLNQFELMKVEKLQIVNSLPRSLVVLYALVEECEDRFGEETSESIIEKINELFPIQEEEEEEAGEGEGEGEEDAEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK43</accession>
    <name>Q5AK43_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosome-interacting GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C504900CA</name>
        <name evidence="6" type="ordered locus">orf19.11460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ribosomal function.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721886.1">
        <property type="nucleotide sequence ID" value="XM_716793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK43"/>
    <dbReference type="SMR" id="Q5AK43"/>
    <dbReference type="FunCoup" id="Q5AK43">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK43"/>
    <dbReference type="GeneID" id="3636416"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504900CA"/>
    <dbReference type="CGD" id="CAL0000184764">
        <property type="gene designation" value="orf19.11460"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04900C_A"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AK43"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="66"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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        </source>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9 10" key="2">
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                <person name="Martchenko M."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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    <accession>Q92206</accession>
    <accession>A0A1D8PEC8</accession>
    <accession>Q59QB2</accession>
    <name>ERG1_CANAL</name>
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            <shortName evidence="8">SE</shortName>
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            <fullName evidence="10">Squalene monooxygenase ERG1</fullName>
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    <gene>
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        <name type="ORF">CaO19.406</name>
        <name type="ORF">CaO19.8036</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference key="1">
        <citation type="submission" date="1996-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ishii N."/>
                <person name="Yamamoto M."/>
                <person name="Arisawa M."/>
                <person name="Aoki Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Gene" volume="189" first="119" last="126">
            <title>Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Favre B."/>
                <person name="Ryder N.S."/>
            </authorList>
            <dbReference type="PubMed" id="9161422"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00844-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
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            <strain>SFI-0124</strain>
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    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1984" name="Biochim. Biophys. Acta" volume="794" first="466" last="471">
            <title>Properties of a particulate squalene epoxidase from Candida albicans.</title>
            <authorList>
                <person name="Ryder N.S."/>
                <person name="Dupont M.C."/>
            </authorList>
            <dbReference type="PubMed" id="6378256"/>
            <dbReference type="DOI" id="10.1016/0005-2760(84)90013-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1985" name="Biochem. J." volume="230" first="765" last="770">
            <title>Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes.</title>
            <authorList>
                <person name="Ryder N.S."/>
                <person name="Dupont M.C."/>
            </authorList>
            <dbReference type="PubMed" id="3877503"/>
            <dbReference type="DOI" id="10.1042/bj2300765"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2005" name="J. Antimicrob. Chemother." volume="55" first="905" last="913">
            <title>Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans.</title>
            <authorList>
                <person name="Pasrija R."/>
                <person name="Krishnamurthy S."/>
                <person name="Prasad T."/>
                <person name="Ernst J.F."/>
                <person name="Prasad R."/>
            </authorList>
            <dbReference type="PubMed" id="15845783"/>
            <dbReference type="DOI" id="10.1093/jac/dki112"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7 10">Squalene epoxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:15845783, PubMed:3877503, PubMed:6378256, PubMed:9161422). Erg1 catalyzes the epoxidation of squalene into 2,3-epoxysqualene (PubMed:15845783, PubMed:3877503, PubMed:6378256, PubMed:9161422). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 7">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6 7">
            <dbReference type="Rhea" id="RHEA:25283"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="5 6">Activity is completely abolished by Triton X-100, deoxycholate or Cu(2+), and partially inhibited by thiol reagents, rotenone and antimycin A (PubMed:6378256). The allylamine antimycotic agents naftifine and SF 86-327are potent inhibitors and show apparently non-competitive kinetics with respect to the substrate squalene (PubMed:3877503).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6">50 uM for squalene</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Impairs ergosterol production and leads to increased susceptibility to terbinafine (PubMed:15845783). Also leads to susceptibility to polyenes, nystatin and amphotericin B (PubMed:15845783). Impairs the localization of the membrane-bound transporter CDR1 (PubMed:15845783). Reduces the formation of hyphae (PubMed:15845783).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="5 6 7"/>
    <dbReference type="EMBL" id="D88252">
        <property type="protein sequence ID" value="BAA13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U69674">
        <property type="protein sequence ID" value="AAC49715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711894.1">
        <property type="nucleotide sequence ID" value="XM_706801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q92206"/>
    <dbReference type="SMR" id="Q92206"/>
    <dbReference type="BioGRID" id="1229551">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q92206">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q92206"/>
    <dbReference type="BindingDB" id="Q92206"/>
    <dbReference type="ChEMBL" id="CHEMBL1897"/>
    <dbReference type="DrugBank" id="DB01091">
        <property type="generic name" value="Butenafine"/>
    </dbReference>
    <dbReference type="DrugBank" id="DB00857">
        <property type="generic name" value="Terbinafine"/>
    </dbReference>
    <dbReference type="DrugBank" id="DB00525">
        <property type="generic name" value="Tolnaftate"/>
    </dbReference>
    <dbReference type="DrugCentral" id="Q92206"/>
    <dbReference type="EnsemblFungi" id="C1_08590C_A-T">
        <property type="protein sequence ID" value="C1_08590C_A-T-p1"/>
        <property type="gene ID" value="C1_08590C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646509"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108590CA"/>
    <dbReference type="CGD" id="CAL0000179458">
        <property type="gene designation" value="ERG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08590C_A"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="InParanoid" id="Q92206"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="SABIO-RK" id="Q92206"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="PRO" id="PR:Q92206"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036187">
        <property type="term" value="P:cell growth mode switching, budding to filamentous"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036171">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051668">
        <property type="term" value="P:localization within membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0492">Microsome</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000209848" description="Squalene epoxidase ERG1">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15845783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="3877503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="6378256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="9161422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="9161422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source ref="1"/>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <sequence length="496" mass="55298" checksum="C844CE43A679B920" modified="1997-02-01" version="1">MSSVKYDAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALRELGMIKAINNIRAVDCTGYYIKYYDETITIPYPLKKDACITNPVKPVPDAVDGVNDKLDSDSTLNVDDWDFDERVRGAAFHHGDFLMNLRQICRDEPNVTAVEATVTKILRDPSDPNTVIGVQTKQPSGTVDYHAKLTISCDGIYSKFRKELSPTNVPTIGSYFIGLYLKNAELPAKGKGHVLLGGHAPALIYSVSPTETRVLCVYVSSKPPSAANDAVYKYLRDNILPAIPKETVPAFKEALEERKFRIMPNQYLSAMKQGSENHKGFILLGDSLNMRHPLTGGGMTVGLNDSVLLAKLLHPKFVEDFDDHQLIAKRLKTFHRKRKNLDAVINTLSISLYSLFAADKKPLRILRNGCFKYFQRGGECVNGPIGLLSGMLPFPMLLFNHFFSVAFYSVYLNFIERGLLGFPLALFEAFEVLFTAIVIFTPYLWNEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCG3</accession>
    <name>A0A1D8PCG3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">TRM2</name>
        <name evidence="14" type="ordered locus">CAALFM_C101380CA</name>
        <name evidence="13" type="ordered locus">orf19.10837</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718150.2">
        <property type="nucleotide sequence ID" value="XM_713057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCG3"/>
    <dbReference type="SMR" id="A0A1D8PCG3"/>
    <dbReference type="FunCoup" id="A0A1D8PCG3">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCG3"/>
    <dbReference type="GeneID" id="3640235"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101380CA"/>
    <dbReference type="CGD" id="CAL0000192336">
        <property type="gene designation" value="TRM2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01380C_A"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCG3"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="1471"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2019"/>
            <end position="2050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000197663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2273" mass="260926" checksum="E7C6D8785AAF862A" modified="2017-01-18" version="1">MSSLNTKEIKEIELINLLYKNFPTLRLNQELIINWQVELSDKTSEFSSLSSIVSDNIVLDIDAIDLENEPNIIEILSYLEQDLTVNNNKDDEEEEEEDNDEFKVIILEILIFIISSSVRLRILSHNTLEYLIDSFLKKLSFGGGVTLENIRQPSIISQYMRLIILYMEFGCDTRHFKKLINPLIQKNNPLANLILSEMLLQIFTKYQAQFPVVSITKRINFPFSNDNLKKNFTIHSWFKVNRQLHNFSEDPMTLFTISSSGPVNGNGNEHNGATLKIKLINYTQFMVEIKNNVNGSKIRYTFNHILQETEKNQGFIHFVLTYDNYTNLNLFIDGEYNESIPCPDLHKYLSNWNKISIGEKSDDIALRNNEIILRNLTILNNNLSYEWINLLYNLGLGFDWEVKDFANDTTLHLLTQLNHQGLFNVALKFNEIKEQKKNIGVNNNNNNGNNMLFGSSTVTTNNRNALATFGGTRVKERSFQNIHFNMTHKLVNKEKIANSLAKIKGDNVTFDSNDFFQNLLYQGKKNVKQNVTSSVIFSNQRSIYQAFNVIGGSSVVLRILETSLEITNPKLRDSIVYTVLSLLLTLLSNNWRLEKEFESFNGYGILSVLLTKYKDFSNQLKFDKVLDDHEPETNLLNVLLEFSGHDFEYPYESAVVNPISYRILVLNFDLHYGTESFDYLLFQIHLLLYTSRHKEYNYNELRKMKILRKLVQFLKESKIDDYNMSQTFKEQLAQTLTGILHLDSSVETIVLLSSYIIFALYNNDSSTMCGTITLQVLTDYLCDSTTSIKTLKKFSRSITVHWILLLFRFQESEVVVNCGIRLLTKLLKVLGIHIIRKFFQLNHGLDVLTSFLKDWWDNETVLCSMFLASFGIDTQDTNNSELSQNNDLTEVLNSNINNLQQLIVPEFLLLLNNLVLNSMYTLSLKSGKLLHSNPSTPIKSNNQENVTLALDVLHLINQYITSIKIGFEKSKLLQKFYLSKDFLEGIVELLGYLKLSLSWSNVDIQRNMQTTYEKLAKLIAGFYISNLSNETFLHSFDKLSDFTKIVLLDLVFPEVLGHINQFISVTNFVFNEKQFFDNTIQLLHHYNEELLNQNYFVSYSNFDMFLLCSIAVSELGVGHNLQYVKKMIGDNIIVKFLRLACDWDISFTQSKDSLDSLLKTLLYRQTTILQTDVITSNRLVHVITLLLGMVLTTGPESTTANVELPFNFLRTCYLMRQDEFPLILEKMNCDKSLMEEFFNNLVTKNDNETLLRLQKFPPFVKSILKEFQMLKEQHNKTDYLKVSNMISVTLHNGGKLGQMNSIYIKSFEKDCESIKSQTMNAELAKFNRLVQDKEESIKHLISTYHGLKTEISRLFEDHSTKSYVLDYIENTNRMRKRLVVEDQLPESERLTYNIDVPLKKIDSFTNASAIHQYDAAITATGIDTLSLSSNEEASQFGEDSFEFIESSETEEETEINHVYEDKNRKVSRSLYVGDQIVTLWNISQINGLVPIESLMILGLSHLYLIENYFHSKDGNVIDVEDAPPELRDPILQLVNSQSSNILKNDGKLHRSKNWSLDKLSCISKRHFLLRDIALEMFFSDGASILITCLTTKDRDAIYNKLYSFASGKGVDYDLIQALQSSTNDSLYSFGASSISSKLVSAFSQTSISNMMFLEATKKWKLGEMSNFYYLMIVNTLAGRTFNDLTQYPVFPWVIADYTSETLDLSDPRTFRDLSKPMGAQTPARANEFRERFEALDSLNDHDAPAFHYGTHYSSAMIVTSFLIRLKPYVQSYLLLQGGKFDHADRLFNSIERAWLSASRDNTTDVRELTPEFYYLPEFLVNENNFEFGKLQNGESSHDVELPPWAKGDPKIFIAKNREALESSYVSANLHLWIDLIFGYKQSGEEAVKALNVFHHLSYSGAINLDNINDEVEKRAVIGMINNFGQTPCKLFNRPHPLRDVLNLPNYYLTQFDGNASRLKLVFESKLKAPISKLEISSKNANRWVGRQNCISCEDDLLIRKAKKLKHECGSLLVNDTLFLSVHSSDITTVLQLGHKLFVTGAEDGSIYVWKCNLRPTTTLQYEALLRGHLTSILKIVYTKSFKFGASIDKDGIVIIWDFIRFKYVRKLFPPVLTEENTTVSPLLAVSNESGNFATVHFNKHLNGQLQLFTINGELIISFEFPAVDGQTIEAITFATTNSIMVDNTRTNNVNKHIYWSKEILAVARKKSIELWELIPENGWELKQLDKVDLQDRISGDITVIELFKCSEVDTEDKLIRGNLKLVIGDSTGKVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDW2</accession>
    <name>A0A1D8PDW2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C106770WA</name>
        <name evidence="5" type="ordered locus">orf19.13613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718822.2">
        <property type="nucleotide sequence ID" value="XM_713729.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDW2"/>
    <dbReference type="SMR" id="A0A1D8PDW2"/>
    <dbReference type="FunCoup" id="A0A1D8PDW2">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDW2"/>
    <dbReference type="GeneID" id="3639504"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106770WA"/>
    <dbReference type="CGD" id="CAL0000177463">
        <property type="gene designation" value="orf19.13613"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06770W_A"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDW2"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000177463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="507" mass="58120" checksum="EA5A10B11484FAE1" modified="2017-01-18" version="1">MLASKKKRTRRTKRQPICEQIPTSNTAFFFTLDIPIMPVNFLTSVVFDGPEVIPYWDQIKEYGPTVLPILLTLAGAKYYFHGATNTWERDMHGKVFMITGATSGIGAQIAYELGQRGAQLILLTRRTNDQWVAEYIEDLRDKTNNGLIYAEECDLSSLYSIRKFATRWLDNQPPRRLDGVICCAAECIPRGKSRQITMDGVERQIGINYLAHFHLLTLLGPSLRVQPPDRDVRVLIATCSSQNLGDVDLNDLLWSDKRYPATQPWKVYGTSKLLLGLFAKEYQRQLMGYERKDKAPCNVRINLINPGIVRTPSTRRFLSLGTVWGLIIYLILFPIWWLFFKSAEQGTQSFYFALFAPIFMKIEGGNVVQECKIMTKVRKEYTDDDLQQKVFHNTEELIKQIETKSAIERKKHENAKKTPEQKAKERQEELNRKRDLHIKPETPEELESKLNSLRNQIGMGTGISSNEMPLFPDDETLKKVISSKKNASSNNRDGSKSNKSQKKSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEB0</accession>
    <name>A0A1D8PEB0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosylmethionine-homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">SAM4</name>
        <name evidence="8" type="ordered locus">CAALFM_C108410CA</name>
        <name evidence="7" type="ordered locus">orf19.8016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711874.2">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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        </source>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Dungan J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="2">
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    </reference>
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    </evidence>
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    </evidence>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    </reference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW26905.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C113260WA</name>
        <name evidence="9" type="ordered locus">orf19.4952.1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330721.1">
        <property type="nucleotide sequence ID" value="XM_019475176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFM9"/>
    <dbReference type="SMR" id="A0A1D8PFM9"/>
    <dbReference type="FunCoup" id="A0A1D8PFM9">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFM9"/>
    <dbReference type="GeneID" id="30515074"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113260WA"/>
    <dbReference type="CGD" id="CAL0000180019">
        <property type="gene designation" value="orf19.4952.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13260W_A"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFM9"/>
    <dbReference type="OMA" id="KPASCEI"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111142" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000180019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="151" mass="16520" checksum="FB5114D74C1E3768" modified="2017-01-18" version="1">MKVSFISLATIVLSQLFPSVSATASPDELKIKILKSVECKRKTKSGDFISVHYSGKLEADGKEFDSSYSRGTPLPFNLGGKQVITCWDEGLLDMCIGEKRELWCHPNVAYGSQGIGPIPPNAALIFTAELIDIAGVDKEEEEEKVVNKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG46</accession>
    <name>A0A1D8PG46_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C200600CA</name>
        <name evidence="3" type="ordered locus">orf19.9614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719514.2">
        <property type="nucleotide sequence ID" value="XM_714421.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG46"/>
    <dbReference type="SMR" id="A0A1D8PG46"/>
    <dbReference type="FunCoup" id="A0A1D8PG46">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PG46"/>
    <dbReference type="GeneID" id="3638850"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200600CA"/>
    <dbReference type="CGD" id="CAL0000185460">
        <property type="gene designation" value="orf19.9614"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00600C_A"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PG46"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000004">
        <property type="entry name" value="HIRA-interacting protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000185460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="237" mass="26997" checksum="0A57C0A4C2822E8A" modified="2017-01-18" version="1">MFVNKRLLAYIPKRLYHFKTLPTPNPNALKFISPECNILPMDDKTFEFTTTLQAIHSPLALTLFKIPGVKSVMLGHDFLTVNKQDYINWANLRPEIVEQLDEFLTSKKHPVITKELVDEAQREAEEESELISMIKELIETRIRPAIQDDGGDIELKGFDEETGTVFVKLQGACKSCSASEDTLKHGIESMLMHYVEEVKEVIQILDPEEEIAVKEFERLEQKLKNGNSQGEQAPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGE2</accession>
    <name>A0A1D8PGE2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C201260WA</name>
        <name evidence="2" type="ordered locus">orf19.9549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
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        </citation>
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        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        <subcellularLocation>
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<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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    <reference evidence="8 9" key="2">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="entry name" value="NADPH OXIDASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="41"/>
        </location>
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        </location>
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        </location>
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        <location>
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            <end position="239"/>
        </location>
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        <location>
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            <end position="211"/>
        </location>
    </feature>
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            <end position="319"/>
        </location>
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            <begin position="348"/>
            <end position="521"/>
        </location>
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            <end position="471"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01794"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08022"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000178992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="537" mass="62145" checksum="50509BCE0F2C5FD5" modified="2017-01-18" version="1">MDEVVPRHGDHHNINIKYGYFIFALTIIQIIFFLQVKFIQIKRWNSTGRFSKFWSQLTNPPIWLMVTVWLLIVIFTGGHKISDFSEEYIISAKRYGRMAYCLIPLNIYLVLRPTNSPLLKPGYYLENMNLHKWTSRIIVFCSAIHATGYIYKWVKEGTILNKPFRFLNLLGVIVFVFLVVLAIISVRTFRKKIYSTFYLIHNITAWSMVILITFHARPGVTIFAVISILLLGYQLYLRYYSSYLVNSLKVIDIPTSTLQIIKIPQPNKFPNWLPGSHIRLNYTISKFKSWTTATHPFTIVTIPEDSANNLTLIVKKPNQFVVYPLDSYLLTGPYPSLAPPFFTTANIVNIICGGSGISLGLPIYHHFRSINSTVPVKLVWTVRNQNDTFIMNQLDMTGVQVYVTSIGDTNSESQENQQHQAVPLFVIEEEEEEEGHGLLNNESENGIELQNMPESNEENSETITINSKNNKDNEERKEYFKFGRPKFDEVFAIDDPTTTHDLDNSWVIACGPDELISDAKRWSKDRGYRFYYEKYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH95</accession>
    <name>A0A1D8PH95_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C204830WA</name>
        <name evidence="5" type="ordered locus">orf19.7811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710286.2">
        <property type="nucleotide sequence ID" value="XM_705194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH95"/>
    <dbReference type="STRING" id="237561.A0A1D8PH95"/>
    <dbReference type="ESTHER" id="canal-q59kl3">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="GeneID" id="3648115"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204830WA"/>
    <dbReference type="CGD" id="CAL0000193865">
        <property type="gene designation" value="orf19.7811"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04830W_A"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH95"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000193865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="434" mass="50427" checksum="907A9D8718F164AE" modified="2017-01-18" version="1">MSNYHLIILVHGVWGNSSHLAYVEKQIHENIHSYDGTILYTHKTGSHSGYLTYDGIDVNGKRISDEVWEQTKLIEQEKGGKVTKFSVVGYSLGGLISRYCIGYLSSQGYFDNIEPINFTTFCTPHVGVSVPQSHNFSARLYNRIAPLFLADTGSQFFLRDKVGEFGKPLLVWMADPRSKFYKALAKFKYKSLYANVVNDKRCSWYTASISPDDKVNSSYNKRPENINCKYIKGYQPNVIDVTKPFYYEKVDNLRESSNHRFKWFWKTLNWIKLIGTITVYSPIFIITSIVQRIYNRKRVSEFFQNESNDLLHMYEHEHEVGGGEEEEQQQQYHSSVFADISNKVDDEQETLVEDIYDAMNWKVSHSSTFPPIRLDHNQSYIVEKLNTIGWKKYPIIIRHTKGTHGAAIIKHYDPNFDEGEVIVRHFVKEVFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIH6</accession>
    <name>A0A1D8PIH6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">INP51</name>
        <name evidence="11" type="ordered locus">CAALFM_C209770CA</name>
        <name evidence="10" type="ordered locus">orf19.8953</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714547.2">
        <property type="nucleotide sequence ID" value="XM_709454.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIH6"/>
    <dbReference type="SMR" id="A0A1D8PIH6"/>
    <dbReference type="FunCoup" id="A0A1D8PIH6">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIH6"/>
    <dbReference type="GeneID" id="3643806"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209770CA"/>
    <dbReference type="CGD" id="CAL0000198222">
        <property type="gene designation" value="INP51"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09770C_A"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIH6"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052658">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071280">
        <property type="term" value="P:cellular response to copper ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09090">
        <property type="entry name" value="INPP5c_ScInp51p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF269">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 5-PHOSPHATASE INP51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="154"/>
            <end position="506"/>
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            <dbReference type="ARBA" id="ARBA00008943"/>
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            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000198222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27955.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="986" mass="113084" checksum="8E431443777FE800" modified="2017-01-18" version="1">MRLYLIEKPRTFVITTNTHALIIRHPSPTYKHSGIKGLVSGHSKDKDQNKDTKVLVEFVLKEYLDLSLYRDITPKHGGLLGLLGLLNVKGKTFIGFITRDEWTASATVTDRIYKITDTEFYCINNDEYDYLLDKEYENMSHQERERLRYPAASVQRLLSSGAFYYSKQFDMTSNIQERGFVSSDYKLIADSSFFKSFMWNGFMTEELIETRKRMSPAEQKIIDKSGLLIIVIRGYAKTVNTTVGGCEALMTLISKQSCAKEGPLFGDWGSDGDGYVSNYLESEIIIYTEKFCLSYVIVRGNVPMYWELENNFSTKTILAANGKQIAFPRSFEASQEALVRHFDRLSSQYGDIHVLNTLSDKSYKGVLNSAYEEQLKYFLQNRESTDIGYKVLYTRIPIASSRIKKIGYSGQNPYDIVSLLSNSIIDFGALFYDSKPNSFIGKQLGVFRINSFDSLNKANFLSKIISQEVIDLAFRDIGLELDRELYVKHAQLWEENDLWISKLTLNFASTSDKLHTSHNSIKSSFVKSHITKKYFGGVVESKPNEIAMLKLLGRLQDQSPVTMFNPIHNYVNKELNKRAKDFTSKLDLSVYASTFNVNGSVYEGDIDKWIYPEENDYDLIFIGLQEIVVLNAGQMVNTDFRNKTQWERKILSVLQKRNKYMVMWSGQLGGVALYFFVKESQVKYVSNVECSFKKTGLGGVSANKGGIAVSFKFSDTTICFVSAHLAAGLSNIEERHQNYKALIKGIQFSKNRRIQNHDAVIWLGDFNYRIDLTNDQVKPMILQKLYAKIFECDQLNKQMANGESFPFFSEQEINFPPTYKFDKGTKVYDTSEKQRIPAWTDRILFLSRQNLIEPLSYNSCQNLTFSDHRPVYATFKITVKIINHTIKKNLSDEIYKNYKDSHNGIFDILVKSFDNKELNEEKDASLPAPSSDKHKWWLEGGKAAKIIIPGLEDDNMVMNPWRPINPFEKSNEPEFVSKNDLEAIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIJ7</accession>
    <name>A0A1D8PIJ7_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">Alpha-1,6-mannanase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C210160WA</name>
        <name evidence="3" type="ordered locus">orf19.9334</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714410.1">
        <property type="nucleotide sequence ID" value="XM_709317.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="3643932"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210160WA"/>
    <dbReference type="CGD" id="CAL0000183164">
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    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
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    </dbReference>
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        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="20"/>
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        </location>
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        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
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            <end position="386"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47338" checksum="A61F9A6AE7F57A19" modified="2017-01-18" version="1">MQSLHFILIVLFFISCISNALTIQKDSLGLKRTSLSSTFDPHDAFETAVNSTWSTFWNNTNQGFSQSDPSCLESQTFQYSVVWDVAVAGLAIVESRDISKTNDVATSLYKYQNSHGWFAATPGNTHSYVDDNCQVLWVFLQAYELTHNEKYLTTANKLMELIQGQWSNEVGGVRWKVDGDYIASISTLEAALSAVKLYEQNKDDSLLSFAKKCLSWLDDNLLDKSDGFYYDGLNVNNKTNIDKGKLTYTVGVAISTYSYLYKYTNDEQYVLIATAKANGTLTSKTFLNHNGYWNNGLRYVHLLFDGFSDLITICDKRGFIDSVWKQGQYIYENDQLPGGNNVGNYLDLSKPIESHLTSSFHKKENHDSKDEVEINHKQSSGSTHHNYYCNNHSKQFKRSLMDDGSAAQIFYAISKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK67</accession>
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        <recommendedName>
            <fullName evidence="6">Seipin</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">orf19.6970</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714676.1">
        <property type="nucleotide sequence ID" value="XM_709583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PK67"/>
    <dbReference type="GeneID" id="3643650"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305330CA"/>
    <dbReference type="CGD" id="CAL0000183372">
        <property type="gene designation" value="orf19.6970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05330C_A"/>
    <dbReference type="eggNOG" id="ENOG502S0BA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PK67"/>
    <dbReference type="OMA" id="DVKWTGF"/>
    <dbReference type="OrthoDB" id="4010679at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000183372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37633" checksum="4AF60E0838F7BAE2" modified="2017-01-18" version="1">MSWLRYLGLTVPLAALRSYLYMATTATTSLFVLLPIAMITYDQYYKTLIPNESSPIIPLNFTTTTITYKNLKSSSNNNNNNNNNNNNHISNTKNILISNAINPIFQNYQYDDQLIYIFNINIQAICLPHNNLQHEITKINYELISSTTTETTNDKNDNDNDNDNDNNNKSFKQGSIILNCDPYVIYSQNNQFIPFNFRFWLSPYLIEHSQINNINLLPLEIPGDQLKNWNNFKIILNNNNDNDNINNQVSTPTAAQNQEIRYLIDDNFSWIQFDVKWTGFRYYMVKYYYSCYLIGTIIFFMVSAGVGFFTSYTILLLNNRNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK82</accession>
    <name>A0A1D8PK82_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C305450CA</name>
        <name evidence="2" type="ordered locus">orf19.6983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Martchenko M."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Weissman J.S."/>
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        </source>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="177"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000177103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="785" mass="90541" checksum="5B4C76FEE884FA3B" modified="2017-01-18" version="1">MSFSIYELDENIKKLLTVDNYLNGLSVNDFIEEISKDHFLKGAEVNNKAYLDPKPYIRTFESTLRELKQLQAEANEQRVKNERQVDSYELKHSENVLELNQQIDEATKKFDILDTQISDVSTRINPLGNTLNKITNSRDRSLETIFLIRAYHGFFMKEQYLPLETLKNSKKLDDKLKCAKTVRNLLNLAKKVSDEKSSKSMKCITTIEQFGETMEKELLRKFEIASEDEDDIDFDMMNQIAQILFEYNEGINVIQTFVIKNDIVIENEEKSLDEQEWALLADSRRSDFKIDEQATFDTLKFEIKSRARISKKVFADPTPVIKIFIQRMYAQIIRNKVTSLLQKSLSVSPLAHVRVLHSLYTLVGDFTEQIKDYLTTEELDKDQELSAILDQSHSDLFVEYIGDNVYFNREKKNLEETIYGIIHQFNTANENIIANKSLAARLENLDNVQKPEKDRFSFASEKKRMNQFKQYVTAKLKDRTRNSEPEPTFMECKSLNVGNVETVLKSVIESVARLLELVPTKSADYALEVLEILIIDFGKLYIGAGLEVVYDECKKNASLDYLSSFNTISELLFLMSSCIKRIILPIATNIPSIKTRMSNMVNGFVAQCEISLNVILNDTLDHFRVKLQSQLAKQKKRDFNCNNIEDDTEACELVSNYLVEIHSSIVSAMNGANLEKILIKIGMEVLHQLLEHYKKFTVNSIGGIVLTKDVIRYQSVIDGWKIPELSEQFQILREIGNLFTVQTDLVNSLVTEGQLANMKPYTVRQYITKRADFNPSYADKFFKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMZ8</accession>
    <name>A0A1D8PMZ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="12">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">SPE2</name>
        <name evidence="19" type="ordered locus">CAALFM_C500700CA</name>
        <name evidence="18" type="ordered locus">orf19.8199</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="12"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714200.2">
        <property type="nucleotide sequence ID" value="XM_709107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMZ8"/>
    <dbReference type="SMR" id="A0A1D8PMZ8"/>
    <dbReference type="FunCoup" id="A0A1D8PMZ8">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMZ8"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PMZ8"/>
    <dbReference type="GeneID" id="3644116"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500700CA"/>
    <dbReference type="CGD" id="CAL0000185891">
        <property type="gene designation" value="SPE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00700C_A"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMZ8"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000011">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 12" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042320310" description="S-adenosylmethionine decarboxylase beta chain" evidence="17">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042320311" description="S-adenosylmethionine decarboxylase alpha chain" evidence="17">
        <location>
            <begin position="81"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="13">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="13">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="13">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="16">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="15">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000185891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW29513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="381" mass="43552" checksum="29DF3D03E7D31891" modified="2017-01-18" version="1">MVAPALIYSNHELSTAIDSTHAFEGPEKLLEIWFYESKELSPINLRDIKFDTWIEILNLVHCEVLSKVSSNLCDAFLLSESSLFVFPHKIILKTCGTTTTLACLDLLFETVNKELLQNEGLKATFQSKNIYQIFYSRRSFMFPDRQIHVHGNWQEEVKLLNQYFNNGKSYIVGNNTNWHLYVGGNGKTKNPVASTTTTTTPVVNDCTLEIIMTQLSLEASQQFYTTRKPGDTAIDSNHDLGHDLGQEILKQTGLNELFKFKKQPTMPGLSSSPIKEIHDGFAFTPCGFSSNSINESDYYTIHVTPEPGWSYASFETNMIGDYKAIVDKCINVFQPGQFMVTFLTNTDMEKFECCLDDYKVNHREELDVEDYKLYFVEFVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNB3</accession>
    <name>A0A1D8PNB3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ordered locus">CAALFM_C501960CA</name>
        <name evidence="21" type="ordered locus">orf19.10685</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714593.1">
        <property type="nucleotide sequence ID" value="XM_709500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNB3"/>
    <dbReference type="SMR" id="A0A1D8PNB3"/>
    <dbReference type="FunCoup" id="A0A1D8PNB3">
        <property type="interactions" value="738"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNB3"/>
    <dbReference type="GeneID" id="3643738"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501960CA"/>
    <dbReference type="CGD" id="CAL0000188515">
        <property type="gene designation" value="orf19.10685"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01960C_A"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNB3"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0000188515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AOW29625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="627" mass="69608" checksum="9CF1E8F7F7512747" modified="2017-01-18" version="1">MLIQSLLPRVGSRRLFPRSLPPLRNSINYTPCIRRFHQSCTRYNLTSEQEEILHQERARDYVDVCIVGAGPAGLSTAIKLKQLDNEQGNGDLRVIVLEKAGDFGSHIVSGAVIEPQAFKELFPESELTEENGIPLPSDIITKVTSDHMKYLTPNSAFPLPEPPQLTNKGKNFIVSLNEVVKYLAEQAEELGVELYPGISVNELVYNEDKSAIKGIITQDMGVDRNGAPKDSFEPGMEFFARLTVLAEGCHGSLTKNAISNFNLRENSEPQTYGLGIKEVWEVSPEKFDKGYVGHSLGYPLTSKEYGGGFIYHFGDGLVAVGLVIGLDYANPYISPYQEFQKMKTHPFYANVLKGGKCISYAARALNEGGYQSIPKLHFPGGILVGCAAGFVNVPKVKGTHTAVKSGIVAAETIISTFKQMELDPCDEENFEELSTPIDLSQYEENFKDSWAYKELYAVRNVRPSFNSPLGMVGGLVHSGLSTMITQGKEPWTLSHHGTDSGATQDANKFQPIEYPKPDNELTFDILTSVSRTGTYHDEDEPCHLKIPDQDCRKHAELNWTKYRGVEQRFCPAGVYEYIEDESEPLGVKFQINSQNCIHCKTCDIKVPSQDITWSVPEGGDGPKYYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNI3</accession>
    <name>A0A1D8PNI3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cta7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">CTA7</name>
        <name evidence="10" type="ordered locus">CAALFM_C502700WA</name>
        <name evidence="9" type="ordered locus">orf19.11764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720596.2">
        <property type="nucleotide sequence ID" value="XM_715503.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNI3"/>
    <dbReference type="FunCoup" id="A0A1D8PNI3">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNI3"/>
    <dbReference type="GeneID" id="3637776"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502700WA"/>
    <dbReference type="CGD" id="CAL0000201094">
        <property type="gene designation" value="CTA7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02700W_A"/>
    <dbReference type="eggNOG" id="ENOG502RBGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNI3"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000201094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="834" mass="95357" checksum="3AB50E58CE90FDAF" modified="2017-01-18" version="1">MGTAREHLHAQYQPSPPGPIPSHLTSSFGGTAHHTQPQGPPPSTQYGYSQPIQQLHPIQQYPVLNQASSQPQPQPQPQPQASSPSPIPAVTHSPVTTSTTHTPDQNGASKQRMRVVKACDRCRSHKIKCSGECPCATCLKQAKECTFSNKVFQKRTKGIELPEPKRAKYAEPFGLPEVKKDDQQEYINHLENRVHYLESLLTNTSTDTFKTPLSNEPESEFVTETLFCTSSKWRFSRRHQNLLIAELCRSMYSNLSEESKQLVTLPRYQYFGWNMSGVKYVSSEELPPLPDLGAKLDSKFLTQYYFEEINPLFAILHETVFKEQIVAYEKVLRDQIMLHKDDHDSKGNQTRLFSAMLYLVYALAIRFSEISKPKNPSIEMLQLEEKLFKYGYKVISILSFEWESFELIQGWLLITLYLRVTHRQTSCSHALGQAMDMVKSMGLGFAHDNAKFYSSTAYERLKAKRIFWCVFTFDRVFGLQTGRYCGIRDEDFNNEFPSYDFKHETEKDDWLTLPALGLIHIARVSNFVHTAATDNPHLIKYQQVNAELVKLHEWFNANGFRNDLFFNKKNDSSSLVKAQVKLHYYDLVLCIHSKILFNYIGRRIASHGLKVEMVIDACNGVIEVLDKTNKAGLLYTPWYSVLLLLFNVGVNAITLINGGAFVEQAREVLKNAMRLLTILRKSPIRNEQNKLVFRERFKMVRECIWALKMANRILTLRLQEDIGVLNSIGVDHGSSDVNKQTFTQLGIASESVEGKSTQPKTNEFNQVFEKHLHRSSEIRQSITNDVDSPVSVNSDSTSNVQSIEPVDTYSSAEIDNLLGNIQWFDQWTDFNIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNS3</accession>
    <name>A0A1D8PNS3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mtr10p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">MTR10</name>
        <name evidence="3" type="ordered locus">CAALFM_C503760CA</name>
        <name evidence="2" type="ordered locus">orf19.8717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711171.1">
        <property type="nucleotide sequence ID" value="XM_706079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNS3"/>
    <dbReference type="SMR" id="A0A1D8PNS3"/>
    <dbReference type="FunCoup" id="A0A1D8PNS3">
        <property type="interactions" value="1272"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNS3"/>
    <dbReference type="GeneID" id="3647235"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503760CA"/>
    <dbReference type="CGD" id="CAL0000185976">
        <property type="gene designation" value="MTR10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03760C_A"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNS3"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035719">
        <property type="term" value="P:tRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="959" mass="110317" checksum="AE6BC324B0E1E9BB" modified="2017-01-18" version="1">MSSDTIAQLNSALVTMYSNVPQQEKMTATHYLEEFQKSQQAWDIVHQILNDENNGNSNIQLKIFAAQTLRSKIIYDLSAQFPESNFENLKNSLLEILSKYTAPNQKLIRTQLSIALSHFALQYLSWRNALSEIINKLSSSETLLPVLLEFLKILPEELSDVKKTNLTDSEFNQRTQELISDNVEQVMMILKNLTESNTNNNASMNSSILDCLNSWIKECAVEQVLQINSLVSLVFQSLSNDQTFEKAIECLVTIIRETRDIDNYEIIDALYQQVLQLNKYMHENTPDKLEDPEYVDGLTRLYVECGESWHVLIGKNPAHFKPLVLIILECTKYDEDLDIVKYTFQFWYQLKQLITLPKFQESKAVFGDIYLQLITVIIKHLTYPISGNDNDLFNGDKEQEDKFKEFRYEMGDVLKDCCAVAGATKALQVPFEQIQNIISNSQGHWQYLEAPLFSMRTMAKEVPLKENTILPTIMSYLVQLPEHPKIRYAATLVLGRYTEWTSKHPEFLEPQLNYITKGFEVADKNNDIIMATSHALMYFCQDCSEFLVNYLEQLYMLYGQVKDQMDLESNYELADGLAHVIAKVPIDSLYKTTEMFIEPTMNYLSKVLAENPTDESNKLIADQIEVISIFIEVLKCPDSDWEKPKYPVAGLFVDKIWPLTTQILSKFGSSVIVSERCMKLLKNAIKSFGLFLSSILPDLANLLHQGLQSTQFGCYIWVTGVLIREFGDEYSPEAIKNAVYEFGLQQSLTVFDLLFSKSEEQLKQIPDVIEDFFHMINDLLMFYPFQLIPKFDILKNVFKVVDLTLSYVNEFEPIISCIHFMIDLISWGLPNPPISLFDMGDTSPLREAVQQFLLIDNQGGELLRVTLNGILFKFHNDIQQDANDLMLKILIVVPNNDTALGWLKQVVEALPNVNEKETGRLLNTVKVALPNKDNRRVRSALRDFINWYSRRNVTPRSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP17</accession>
    <name>A0A1D8PP17_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C504790CA</name>
        <name evidence="2" type="ordered locus">orf19.11447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721874.2">
        <property type="nucleotide sequence ID" value="XM_716781.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP17"/>
    <dbReference type="SMR" id="A0A1D8PP17"/>
    <dbReference type="STRING" id="237561.A0A1D8PP17"/>
    <dbReference type="GeneID" id="3636446"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504790CA"/>
    <dbReference type="CGD" id="CAL0000182072">
        <property type="gene designation" value="orf19.11447"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04790C_A"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP17"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000182072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="216" mass="24560" checksum="6117961F55B81FC4" modified="2017-01-18" version="1">MLGNLQSETQPSKNVLDQYIAEINSKISGQNFKIERKTHEITGDLYYIFINTLSDEIVQESSVYTTAELTVIKYLIRNIIEASDYRCSLARVNANQTISTNTNKNLMEADSMVDRLIDDGWFISTIDDRLMLSIKTLCELKEYLIETYGVNGDDTDADGKVLLCTQCKEIVTLGWIIPSGSKPFHRKCYDVYCRTNQIYPEDESDLLRVGPDPSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP41</accession>
    <name>A0A1D8PP41_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C504920CA</name>
        <name evidence="8" type="ordered locus">orf19.11463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721889.2">
        <property type="nucleotide sequence ID" value="XM_716796.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP41"/>
    <dbReference type="SMR" id="A0A1D8PP41"/>
    <dbReference type="FunCoup" id="A0A1D8PP41">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP41"/>
    <dbReference type="GeneID" id="3636419"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504920CA"/>
    <dbReference type="CGD" id="CAL0000181614">
        <property type="gene designation" value="orf19.11463"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04920C_A"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP41"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000241">
        <property type="entry name" value="Antiviral helicase SLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="264"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="502"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1328"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000181614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1929" mass="218845" checksum="28B158CB6CDD52BF" modified="2017-01-18" version="1">MASYTVSSTKSYMQAMQPMIEALNRINTGNKQQKVPNIDNENAKITPIDKILNKFANVTIDSLKHIGNKSSGADVVIHEIEDACNKISKQRGLEKSEIYTLVKSLLLQSPTDEELQSSLFDILGFDEFDLISKIIQNKRAFATRESSGLMSSEERAQQVIDNHQRAKNQTLLPKSTHQKYPNVFKNPDVGNIISITGKKFALPQGTTRDSYATHEELVIPYPENKPNKWISEKNLVKISDLDFLCQGTFKNYKNLNKMQSLVYPVAYNTNENMLVCAPTGAGKTDVALLTILHTINQFVTETVTEDGDVSVDIDYDEFKIVYVAPLKALAAEIVEKYSKKLKWLGINVRELTGDMQLTRQEIINTQIIVTTPEKWDVVTRKSTGDSELVAKVKLLIIDEVHLLHEDRGSVIETLVARTLRQVESTQSMIRVVGLSATLPNYMDVADFLGVNRSVGMFYFDQSFRPVPLQQQILGVRGKAGSKLARENIDKVSYEKLADYINQGLQVMVFVHSRKDTVNTARTFIRMAVEYGESEIFNCSEADSYEKYKREASNKNRSKELKELFVHGFGVHHAGMLRSDRNLTEKMFESGAIKVLCCTATLAWGVNLPAAVVIVKGTQVYDSKAGGFVDLGISDVIQIFGRAGRPQYEKFGTGILCTTSDKLDHYVSLLTQQHPIESKFGDKLIDNLNAEISLGTVTNVEEAVQWLGYTYMMVRMKQNPFAYGIDWKELQEDPSLTNRRREMVFTCAKRLHHLQMIIFDENSEAFTPKDLGRIASDFYLLSNSVEIFNQMMNPLATEADILSMISMSSEFDSIKFREEESKELKQLVEEDAPCQVAGDVDSPQGKTNILLQAFVSQAHIKDSALISDSNYVAQNSARICRSLFLIAMNRRWGKLMNIMLSLCKSIDKRIWAFEHPMTQFELPQPVLRNIKAKNPSMLALRDMEAGELGDLVHNFKMGSILYKLIGKFPFIDIESEIFPITTNVMRVHVDLQPDFVWDDKYHGSAQFFWLTVEESDRSEILHVEKFILHKKQLHSPHEMDFMIPLSDPLPAQVVVRVVSDSWIGSETVHAVSFQHLIRPSNETIKTDLLRLQPLPVTALHNPDVEQIYSSKFKYFNPMQTMVFHSLYNTNSSVFVGSPTGSGKTVVAELAIWHAFNEFPSSKVVYIAPMKALVRERVDDWRERICKNTSHRLVELTGDSLPTIQEVKEADIIITTPEKFDGISRNWQTRKFVQQVSLVIMDEIHLLASDRGPILEMIVSRMNYISSQTKKPIRLLGMSTAVSNAFDMAGWLGVKNGLFNFPQSVRPVPLQMYIDGFPENLAFCPLMKTMNKPAFMAIKQHSPNKPVLIFVASRRQTRLTALDLIHLCGMESNPRRFLKISDDELQDILENVKDDTLRLSLQFGMGLHHAGLVESDRQISHKLFEQGKIQILIATSTLAWGVNLPAHLVIIKGTQFFDAKIEAYRDMDLTDILQMMGRAGRPAYDTSGIAIVYTKESKKVFYKHFLNLGFPVESSLHKVLDNHIGAEISAGTITTRQEAMDFLTWTFLYRRAHNNPTYYGIEDISQYGISQYLAKLIDSTIENLVESKCVYTGGSDELHATPFLEISSYYYLSHLTMRNFVNNVTPDFEFRDCLRVLCQATEYNELATRHGEELINMEMSQAMRYPAEDLNCEFIWDPHVKAYLLIQAYMSRVELPIADYAQDTISVLDQALRILQAYIDAAAELGYFKVVMSFIQLMQCIKQRYWYDDDPVSALPGLKLISEGKTNQTLKQLGSMKPGQLFGLAKKLGVKGENIENKETNYDYGDGDSDEMAKKQFVKIASHLPTGNLEIKQQEQDSIKVVLTHDNYPLNNDFKVYCPHFPKPQRESWFVILHDGEELHLLKRASPRLSNKKGIVACDLDIPDDLFGKELYLECVNDGLDIAYSKKISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPA6</accession>
    <name>A0A1D8PPA6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C600230WA</name>
        <name evidence="9" type="ordered locus">orf19.8772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712299.2">
        <property type="nucleotide sequence ID" value="XM_707206.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPA6"/>
    <dbReference type="STRING" id="237561.A0A1D8PPA6"/>
    <dbReference type="GeneID" id="3646061"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600230WA"/>
    <dbReference type="CGD" id="CAL0000198722">
        <property type="gene designation" value="orf19.8772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00230W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPA6"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000098">
        <property type="entry name" value="Diacylglycerol pyrophosphate (DGPP) phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF192">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111287" description="Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000198722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="362" mass="41118" checksum="05FBE942DA661BB6" modified="2017-01-18" version="1">MKRENFFSFKWPFFLGLCSLSCLCRCKKNTQIMVTDWVFTINRLQFSGLITISYIFDFLFYLTILILSATLGRTLPPRYHEFSIYDITLRYTHFPETTILVRVWLLVLISAGIPLTQFLLFSIFVVLPIRRRIWDFLAGCLCLLGAMATQLLVTVLLKNIIGLPRPDFIDRCEPMIQNIPLTSLSTVAICTQPDWNLVQEGFRTFPSGHSATVFTGMTIAALNFAARLQTFDNRNNSFKVFITISPWLIAACVASTRVSDNRHFLKDIIAGAFIGTCIGSVFYLQYHPSIFNLANAGRSFPPRRFGIQRFFQNIGGFWKLDGESSDRALGAEDLEKLSNEQLGQPARITSMADNIEVVNKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPA9</accession>
    <name>A0A1D8PPA9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tlo13p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">TLO13</name>
        <name evidence="4" type="ordered locus">CAALFM_C600030WA</name>
        <name evidence="3" type="ordered locus">orf19.6337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710505.2">
        <property type="nucleotide sequence ID" value="XM_705413.2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPA9"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PPA9"/>
    <dbReference type="GeneID" id="3647891"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600030WA"/>
    <dbReference type="CGD" id="CAL0000176226">
        <property type="gene designation" value="TLO13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00030W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPA9"/>
    <dbReference type="OrthoDB" id="4092858at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="entry name" value="Mediator_Med2_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11214">
        <property type="entry name" value="Med2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000176226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="174" mass="20567" checksum="7B6737C32345CB34" modified="2017-01-18" version="1">MPENLQTRLHNSLDEILKSSGYIFEIIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLDDAEWCLGVMVEKKKKLDELKVKEEAARKKEEEAKKEEEXKKAEEAKKCFILLFCQICTTFNLCANILFYLIFIYFYFTILFYRTFYIFSLSTHLLYNIFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPD3</accession>
    <name>A0A1D8PPD3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C600490WA</name>
        <name evidence="3" type="ordered locus">orf19.11686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711262.2">
        <property type="nucleotide sequence ID" value="XM_706170.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPD3"/>
    <dbReference type="FunCoup" id="A0A1D8PPD3">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPD3"/>
    <dbReference type="ESTHER" id="canal-q59ng0">
        <property type="family name" value="CGI-58_ABHD5_ABHD4"/>
    </dbReference>
    <dbReference type="GeneID" id="3647150"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600490WA"/>
    <dbReference type="CGD" id="CAL0000193235">
        <property type="gene designation" value="orf19.11686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00490W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPD3"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="181"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000193235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="463" mass="53368" checksum="A271B3D454863B42" modified="2017-01-18" version="1">MLILKRLLTTSCTLLDTSPKNYYKIIAPSTFETKKCESYNEKHSSTTTEITATSTATVADTVEDELTITHKTKRKFISTYKRSTHPTSVPLSKIFSNNFPLSINESFEDYKYRNNPLKFQHDLLSILPFYPTPDPQVKTKEGRSSEVLKVEIDDKGNYINEFVIYPENYNPQVMPDDEYHHLIMVHGYGAGLGFFLKNFDEISNFQPNNTQNNKYIVHAIDLLGYGCSSRPNFYPQNLDQVENWFHDSFITWLQKRNIPSDKTIVMAHSMGAYLMATLAINRNLKFCSKLLMVSPGAIIKHQTPVQVPRYFVKLWERNISPFTIVRKLGPLGSKIVSGWSSRRFDKLTRQEKKLLHKYSYGIFQSKGSGEYMLNYLLAPGADARHPLVDRGIDRITCDVSWWYGKEDWMDKKGGQICSAIINNKGEFKSDVKIIEDSGHHIYLDNIKKFNSMVLEEMNQLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPU9</accession>
    <name>A0A1D8PPU9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C602160WA</name>
        <name evidence="7" type="ordered locus">orf19.10960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712496.1">
        <property type="nucleotide sequence ID" value="XM_707403.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPU9"/>
    <dbReference type="SMR" id="A0A1D8PPU9"/>
    <dbReference type="STRING" id="237561.A0A1D8PPU9"/>
    <dbReference type="GeneID" id="3645889"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602160WA"/>
    <dbReference type="CGD" id="CAL0000180548">
        <property type="gene designation" value="orf19.10960"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02160W_A"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPU9"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000180548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="556" mass="64132" checksum="AE6F27BD03044FCC" modified="2017-01-18" version="1">MNYTRVNSSEELEVYEEVGRGGFGVVYRGIIKSTNQEVAIKQIDLEKDSTDLIEINKEIQIISECHCQQITSYMGSFVKNYKLWVIMEFIDGGSIFELLKPGPIDDEKIVSFILYEILLALNYLHNQGKIHRDLKSQNILISKTGDIKLTDFGVSTQLSSNFSKRNTTVGTPYWMAPEVIVNNNGGHSYKADIWSLGCCCYEMFTGKPPLQSKYPPMRALRLISKCQKNQDFIKLIELNELDISWEFKDFLHQCFIEDPKLRASASKLLKHKFITKHIHDKDKIKLLKKLITKKQLWNQQNHIVKTQNYYVPTEIYNNQLKWNMDDQNGNENQQTELTKESGDQHTGNTIKFDISSLMLNNDLEDDIEEDVEDDAHEERKSSPSSEPNDDIIGFFKNDFNNILTKIFNKIDNRNQLSRLQYDQLVEMNNLMGQLITNDNGGTNNNRKILLFQYLKYLIKELLKEKNSHINRLILPSSILHNTGTNGITTNISGNTLVNNNNHVTNMTNFTTNGILSSTTSTTTVNHNRTTSHTWTKFDEIESSLLESWINRMEQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ15</accession>
    <name>A0A1D8PQ15_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C602950CA</name>
        <name evidence="2" type="ordered locus">orf19.13019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719135.1">
        <property type="nucleotide sequence ID" value="XM_714042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ15"/>
    <dbReference type="SMR" id="A0A1D8PQ15"/>
    <dbReference type="STRING" id="237561.A0A1D8PQ15"/>
    <dbReference type="GeneID" id="3639188"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602950CA"/>
    <dbReference type="CGD" id="CAL0000190125">
        <property type="gene designation" value="orf19.13019"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02950C_A"/>
    <dbReference type="eggNOG" id="ENOG502RZ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ15"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000190125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="360" mass="42199" checksum="776BB11A0473FD64" modified="2017-01-18" version="1">MLLNLVIIVVIILIGYLTVSHFWFNPSHSSVINNIPPVASNFKWETQQPLPIRPFVNKKNFNPSMAIKNISDTPQDWLLIENTYYNNVRQRQKHIALEPEILTFIHNNNRTKQAVGEFYDMVTQFLLSRYPMYFKYDFWSGIVTNTITNDKFPKYSKSLIPNYQSMVEILGRNIEEDFLILIKNNPHDKEEEYIMRASLNGFPAGFDPRVNFNQPISFIHQPVPQYKSRLQFSMTKFFNNSQPDKLWVRHNWGIQTHNSYFNMDTNHGRPGDKIHQLSMNEIDFDNEGCCLRCERQLFTRMPQSGAIIMTIRTYLTPIKTIKQEGLGKELSRAIDGLPDDLAFYKKRNSWGEAVKEYLAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQG0</accession>
    <name>NAG3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily multidrug transporter NAG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Multidrug resistance protein 97</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-acetylglucosamine utilization protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAG3</name>
        <name evidence="11" type="synonym">MDR97</name>
        <name evidence="10" type="synonym">TMP1</name>
        <name type="ordered locus">CAALFM_C604610CA</name>
        <name type="ORF">Aorf19.2158</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Eur. J. Biochem." volume="268" first="2498" last="2505">
            <title>Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans.</title>
            <authorList>
                <person name="Yamada-Okabe T."/>
                <person name="Sakamori Y."/>
                <person name="Mio T."/>
                <person name="Yamada-Okabe H."/>
            </authorList>
            <dbReference type="PubMed" id="11298769"/>
            <dbReference type="DOI" id="10.1046/j.1432-1327.2001.02135.x"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="FEMS Microbiol. Lett." volume="212" first="15" last="21">
            <title>Characterization of the CaNAG3, CaNAG4, and CaNAG6 genes of the pathogenic fungus Candida albicans: possible involvement of these genes in the susceptibilities of cytotoxic agents.</title>
            <authorList>
                <person name="Yamada-Okabe T."/>
                <person name="Yamada-Okabe H."/>
            </authorList>
            <dbReference type="PubMed" id="12076781"/>
            <dbReference type="DOI" id="10.1111/j.1574-6968.2002.tb11238.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Biochem. Biophys. Res. Commun." volume="301" first="1099" last="1108">
            <title>Two membrane proteins located in the Nag regulon of Candida albicans confer multidrug resistance.</title>
            <authorList>
                <person name="Sengupta M."/>
                <person name="Datta A."/>
            </authorList>
            <dbReference type="PubMed" id="12589826"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="1451" last="1469">
            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
            <authorList>
                <person name="Lan C.Y."/>
                <person name="Rodarte G."/>
                <person name="Murillo L.A."/>
                <person name="Jones T."/>
                <person name="Davis R.W."/>
                <person name="Dungan J."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="15387822"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Appl. Environ. Microbiol." volume="75" first="5840" last="5845">
            <title>N-acetylglucosamine utilization by Saccharomyces cerevisiae based on expression of Candida albicans NAG genes.</title>
            <authorList>
                <person name="Wendland J."/>
                <person name="Schaub Y."/>
                <person name="Walther A."/>
            </authorList>
            <dbReference type="PubMed" id="19648376"/>
            <dbReference type="DOI" id="10.1128/AEM.00053-09"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2015" name="Mol. Microbiol." volume="96" first="1226" last="1239">
            <title>An expanded regulatory network temporally controls Candida albicans biofilm formation.</title>
            <authorList>
                <person name="Fox E.P."/>
                <person name="Bui C.K."/>
                <person name="Nett J.E."/>
                <person name="Hartooni N."/>
                <person name="Mui M.C."/>
                <person name="Andes D.R."/>
                <person name="Nobile C.J."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="25784162"/>
            <dbReference type="DOI" id="10.1111/mmi.13002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2017" name="Antimicrob. Agents Chemother." volume="61" first="0" last="0">
            <title>Potent in vitro synergism of fluconazole and osthole against fluconazole-resistant Candida albicans.</title>
            <authorList>
                <person name="Li D.D."/>
                <person name="Chai D."/>
                <person name="Huang X.W."/>
                <person name="Guan S.X."/>
                <person name="Du J."/>
                <person name="Zhang H.Y."/>
                <person name="Sun Y."/>
                <person name="Jiang Y.Y."/>
            </authorList>
            <dbReference type="PubMed" id="28607012"/>
            <dbReference type="DOI" id="10.1128/AAC.00436-17"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 6">MFS transporter involved in N-acetylglucosamine (GlcNAc) uptake (PubMed:19648376). Confers resistance to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, and contributes to virulence (PubMed:12076781, PubMed:12589826).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 7 8">Expression is induced in presence of cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline (PubMed:12589826). Expression is up-regulated during biofilm formation (PubMed:25784162). Expression is also increased in high-iron conditions (PubMed:15387822). Expression is decreased after combined treatment with fluconazole and osthole (PubMed:28607012).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Leads to increased susceptibility to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, but not to actinomycin D, fluconazole, ketoconazole and colchicine (PubMed:12076781). Also leads to attenuated virulence in mice (PubMed:12076781).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712434.2">
        <property type="nucleotide sequence ID" value="XM_707341.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQG0"/>
    <dbReference type="STRING" id="237561.A0A1D8PQG0"/>
    <dbReference type="GlyCosmos" id="A0A1D8PQG0">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_04610C_A-T">
        <property type="protein sequence ID" value="C6_04610C_A-T-p1"/>
        <property type="gene ID" value="C6_04610C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645969"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604610CA"/>
    <dbReference type="CGD" id="CAL0000181510">
        <property type="gene designation" value="NAG3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04610C_A"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQG0"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008645">
        <property type="term" value="P:hexose transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQW2</accession>
    <name>A0A1D8PQW2_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ordered locus">CAALFM_C701390WA</name>
        <name evidence="2" type="ordered locus">orf19.6920</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="24"/>
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            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000197089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="130" mass="15688" checksum="19610C139600434F" modified="2017-01-18" version="1">MIMDSKLAFILFLIKMFILIEMIIQEFFTKSLEEDYDDDYDDDEQFDEKFNNNNNIADNENCPDIIHDEEKSLIYNTMTKQYESRPTIMTLKKKKKSRTSIWGISLQEFIFFIICFIMIIFDWIVIYTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRK9</accession>
    <name>A0A1D8PRK9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tpo2p</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="9" type="ordered locus">CAALFM_C704250WA</name>
        <name evidence="8" type="ordered locus">orf19.7148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    <reference evidence="9 10" key="1">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715197.2">
        <property type="nucleotide sequence ID" value="XM_710104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRK9"/>
    <dbReference type="SMR" id="A0A1D8PRK9"/>
    <dbReference type="FunCoup" id="A0A1D8PRK9">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRK9"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PRK9"/>
    <dbReference type="GeneID" id="3643164"/>
    <dbReference type="KEGG" id="cal:CAALFM_C704250WA"/>
    <dbReference type="CGD" id="CAL0000198917">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_04250W_A"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRK9"/>
    <dbReference type="OMA" id="AYIPSFM"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="298"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="118"/>
            <end position="563"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="563" mass="61745" checksum="3F76B8BFB56B49CF" modified="2017-01-18" version="1">MPASGSISSEEPLMTLKPYEGIPTIEGDEQYLQNYSTAQAGENELLRIESNVQASKALSRIISDSDPVLQRSLLLNEPLPLMGGGRPYPPLLGSRDPYAVTFDGPDDAGFPQNFPFWKKMVYSLGPLFTALSVSLGSAMFSQASPEIMAIYHIGVTPAALTTALFVFGFASGPVIYGPLSELFGRKIIMVISSFLYVCFSFAVATAKDIQTIMICRFFSGFVGSAAFVVSPAIFSDLFSTEQRGTAISTFAGVLFGGPMLAPIFGGFTVKNSSLGWRWTAYFCGIVACLGLVLNVFLLDETHHPIILVKRAEELRRRTGNWGIYAPHEELTLSLKEIVENNIARPLKMLFTESILFLVSIYNGFIYAMLYCLLTAMPLIFQEGYGFRRGVAELPYLAMLLGVFIGIAALILFEQRYLKAMEKNNGKPIPEERLPPVFIGGIFFIIGIVILTVAGDFPKKVHFMVPTVGAGFVGFALMLIFLPTMNYVIDCYLFVAASALAANTFLRSAMAAVFPLFSHQMFVNLTNKYAGTILAGLGVLLLPVPIAFRVYGKKIRENSKYAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRX1</accession>
    <name>A0A1D8PRX1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR01260WA</name>
        <name evidence="10" type="ordered locus">orf19.10738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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    </evidence>
    <sequence length="555" mass="63681" checksum="4ABBA41E22C54EEF" modified="2017-01-18" version="1">MPRQQIKKQEVDEVAMQAAIDDIKSGKISSFRKASQKYGLCATTLRNRMNGVPSRSIAHANEQLFSPLQEDSIAQWILDSEREGTPRTRKDVIEFAGLIAAQEDKPTIHVSDNWFERFKKRHPEIHTVDKKLVSSQTMKSTSRKQAEKFFKNFKQLINENNINHDNVFRVDSTTYIMGKGNSSEMVIPGDDNKVYVQSFEGYDSCTVIEAVSMTGNISPIGIVFSGADLRTKWINDGSPHWYYTATTSGSVSCQIMYSWLNEVFTPYLEQKKSEDEKCLLIMDKDYGTTNTRFQNSCESSGVVPLYLPPCCPHLLSPVDIQTLPRIVSPEYKSKLQELDKKFGFAPVKQRFFLSGYFKARQQLNMTPEEIVDRWAFTGMYPNNIRKVVSLSQDVVAKLKNGAEKTRKGERRRADANKSEENETLSTNDSDDDEVISAEMTKSEIIERSQRNLERRKKQIDRLLVQVAELEFEKNRLRSEVLLQQQLQQGNLTEAEVAKYLEDEDFLEKYALGELFVEKRNNLQDNNENHQQQSEGVLSDVTNITRKRKHSKIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSH1</accession>
    <name>A0A1D8PSH1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hxt5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">HXT5</name>
        <name evidence="12" type="ordered locus">CAALFM_CR03450WA</name>
        <name evidence="11" type="ordered locus">orf19.11862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331073.1">
        <property type="nucleotide sequence ID" value="XM_019475528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSH1"/>
    <dbReference type="SMR" id="A0A1D8PSH1"/>
    <dbReference type="STRING" id="237561.A0A1D8PSH1"/>
    <dbReference type="GeneID" id="3643209"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03450WA"/>
    <dbReference type="CGD" id="CAL0000200935">
        <property type="gene designation" value="HXT5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03450W_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSH1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008645">
        <property type="term" value="P:hexose transmembrane transport"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="84"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000200935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="562" mass="61659" checksum="C36BE41D8F6ABC4C" modified="2017-01-18" version="1">MSSVSSENNSGLFGTDVYDETKENKPKYEHEEGLEFGSDFDFDGEFEKYAAMGAAEKQSGAWMTNFKNLEFPLGVSPSVLVQTLGIFAAFCGILSGVDQSLISGASIGMDKSLHFNSHENSLVSSLMPLGAVAGSILLTPLQRFGRKKALMASCILYTIGAILCAAAPIPKELADGTFNNHRSRDVMYAGRFILGIGVGIEGGGVGVYISESVPSNKRGSLVSLYQLSIALGEVLGYAIAAIFYEVHGGWRFMVGSSLVFSTIVLIGLFFLPESPRYLVFKGKFGEAFNVFARLRDLGDRHSKIEFVQMVQAAEAERELRLTQNKSKVWFELVTIPRNRRALVYGIVMITLGQLTGINAVMYYLSTLMGRIGFSTKNSVFMSLVGGGSLLIGTIPAILYMDKFGRRVWGYNLVGFFVGLVLVGVGYSIDIETNLAAAEGVYLTGLILYMGFFGSYACLTWVVPAESFSLGTRSQGMTICSALLYLWAFTVTYNFNRMKVAMTYTGLTIGFYGGIAFLGFFYQVLFMPETKGKTLEEIDEIFEKPSRQLIKENLSGLKRFWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSI9</accession>
    <name>A0A1D8PSI9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR03670WA</name>
        <name evidence="1" type="ordered locus">orf19.11844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715142.2">
        <property type="nucleotide sequence ID" value="XM_710049.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSI9"/>
    <dbReference type="STRING" id="237561.A0A1D8PSI9"/>
    <dbReference type="GeneID" id="3643220"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03670WA"/>
    <dbReference type="CGD" id="CAL0000197038">
        <property type="gene designation" value="orf19.11844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03670W_A"/>
    <dbReference type="eggNOG" id="ENOG502RYJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSI9"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000197038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="648" mass="74461" checksum="C39C8375FB334495" modified="2017-01-18" version="1">MASGERNLQSFGYSPNNVDNSATHKFHNILEQSDFSKYYSFQYILSEKNLLDSVNTSIIPQNLPNEFEIIAHLKLIKVLGILKVKVLAGVASYASASRWKQYVTNAVRRFMVFLVSLKKFMDIDLGYSLKSSYNQTHEQSHFQFASMMTQLMPPLDVIMVWYSFLSHPKSFYTVLTGCDMEEFANLPLPLHLINQFIDNTTFEFNVPHEYKHNYLQIIACTTIDTLDSQYDVDRFGFEAKCVTITCPNCKHVISEPIKLQNEMETGFFDKKFATKNIYFGEQSLCYCSKIEVLTHDELRKLQLFADASKEKSPLTYLHNSPPKLPEDLEKTSESFQKLFIQIWRSIQAKNLNDIILILEQKCITELLPQAFLLNTYRDLDLISMTVPGDIQIGKNLVELVLKQESFGIKINNLNWLYSSNISNIVSEATSRYSNFFAIVTDPKLSQNLKSTLDIDLVWHTHQLCAFGYFHDCLNSPSHCIIDQRDKISNRLMDGSETFTENLYRALYGQEYFICYCHNCSSVRYGVSNHVFDSTINANLCLENKILGIDLNMVYTSPQSNSIVGITPQSQQYPCICHNTNDFLTNSVTEETLDGEFMENDQKIVSSNDFPNENIDSLIYSNIPEMNNAFLYGPSECSNNEFLRSWCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSJ4</accession>
    <name>A0A1D8PSJ4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_CR03620CA</name>
        <name evidence="13" type="ordered locus">orf19.4380.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715155.2">
        <property type="nucleotide sequence ID" value="XM_710062.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSJ4"/>
    <dbReference type="FunCoup" id="A0A1D8PSJ4">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="GeneID" id="3643182"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03620CA"/>
    <dbReference type="CGD" id="CAL0000182841">
        <property type="gene designation" value="orf19.4380.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03620C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PSJ4"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="390"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000182841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW31100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="867" mass="99307" checksum="8B2F280C695AA13E" modified="2017-01-18" version="1">MIIRTLRSQLRLPKPVYISPPCRYYSTDLEKLKKESDTTESDNSASATGVIDKTHNEVLLYYDHIYPFTTSRNVVKQYLSRFSLPWSTAYDNEKLKQKVWDLSSPLATTAKITEFVPLRRDSGAFVKFKYPPEVPATQFIEEIRENVERNEQERVNSNILTRLYHQIWRNVPKVYSVKGTPWIEDLRRFPSPKLSVKFEGDPLTEEELYVLFRRYGLINEIEPGATEAFIYFHSTRAAISAKHCITGMVLNGGKTTLHIQFVAIKRSNFLVSLISNHTKIAIPVLIALLATFAVLIFDPIREWFIEYKILHNRKSFDQFKESRWFKYLYIPYRTITGWVYSSYDYIDSQIQEVTGSSCSEEDDSSNGSNIVDGQSVRDLKNESNMFWIERYEKSKQLQLWIMENANTFIIVKGPQGSGKEEFVLEHSLGSDERLNKKVLVLECDQLGKARSDNNLINTTASQLGYFPVFTWTNTVSRFVDLGVQGLTGQKSGLSESKETQIKNMFSLATQAIRKITTNEYNKYVKSVERRNKRLKDDEKIEVLKEEQFLQQHPEAKPIIVLNKYSRRADVSSNDFIPPLVADWASGLVQNNTAHVIFLTADVGSLQLLNDALPNQVFKDISLSDASMSSSRQYVCDVLKVKDTSTLDECLEPLGGRMLDLQSFIRRIKSGESPQQAINEMISQAAELINTFFLNSHHKFGAGDSNWDPSQVWLIMKLLSECDTINYSELVKSPLFKVSKETLEILTTLEKYDLISLKRDKGVLDKISTGRPLFKAAFANIISDLRIWKLYETEYIGRLISLEAAKIQKLEEELEKIYKIGKVDGRIDYVSQKIEASNKKILDLEKQAADVASYTGKPDGKSFLGIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSJ8</accession>
    <name>A0A1D8PSJ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">PPH3</name>
        <name evidence="11" type="ordered locus">CAALFM_CR03800CA</name>
        <name evidence="10" type="ordered locus">orf19.11828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331076.1">
        <property type="nucleotide sequence ID" value="XM_019475531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSJ8"/>
    <dbReference type="SMR" id="A0A1D8PSJ8"/>
    <dbReference type="FunCoup" id="A0A1D8PSJ8">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSJ8"/>
    <dbReference type="GeneID" id="3643193"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03800CA"/>
    <dbReference type="CGD" id="CAL0000195388">
        <property type="gene designation" value="PPH3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03800C_A"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSJ8"/>
    <dbReference type="OMA" id="LCEIICD"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PHI-base" id="PHI:9226"/>
    <dbReference type="PHI-base" id="PHI:9543"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
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        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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    </dbReference>
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        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000195388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="306" mass="34696" checksum="D7EB3D1F3C323306" modified="2017-01-18" version="1">MLNLDETIENIKQCKHIPEGDVEELCTKVIELLIEEANIQHIDTPVTICGDIHGQLHDLITLFKTGGELPDTQYLFLGDFVDRGFYSFESFLLLISLKLRYPDRITLIRGNHESRQITTVYGFYDECLRKYGSINVWRYCCEVFDYLSLGAIVGGSQGVFCIHGGLSPEIDTVDQIRVLDRKKEVPHEGGMCDLLWSDPELVNGWSISPRGAGYLFGENEVNKFLHDNNISLIARAHQLVMEGYKEMFNQGLVTVWSAPNYCYRCGNVASVLTIGDDLSREYKVFEASPHDIGSIPSRKPPVEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSZ0</accession>
    <name>A0A1D8PSZ0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ife2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">IFE2</name>
        <name evidence="10" type="ordered locus">CAALFM_CR05340CA</name>
        <name evidence="9" type="ordered locus">orf19.5288</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710369.1">
        <property type="nucleotide sequence ID" value="XM_705277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSZ0"/>
    <dbReference type="SMR" id="A0A1D8PSZ0"/>
    <dbReference type="STRING" id="237561.A0A1D8PSZ0"/>
    <dbReference type="GeneID" id="3648027"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05340CA"/>
    <dbReference type="CGD" id="CAL0000180542">
        <property type="gene designation" value="IFE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05340C_A"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSZ0"/>
    <dbReference type="OMA" id="TNCCLKA"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="258"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000180542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="435" mass="48503" checksum="5F36BED1C2897614" modified="2017-01-18" version="1">MNSLLSRRIISQPKLYKRIISTRTICNSFSLYHSNCQHQHQHQQQQQPQQEVAKTMQAIEYHGNRNLKYVTDRPIPEITHPHDVKIKISHCGICGSDLHEYLDGPIFFDGEINAVSKKKKLGQCLGHELCGVITEVGSDVSHHLQPGQHVVLEANGSCLDKKYLQQSQEEQNDVCSACAHGRYNACKRLGFYGLGYDNGGFAEYIVASENKVIPYDANIIPDEVAALVEPLAVSWHGVRQSKIEECKSPQALILGGGPIGLCTIFALKGHKVTDIVVSEPAEGRRELAQSFGVKTFNPFDYKDAEIQIKELLKMTKTNSGFTHVYDCSGNKATFNTMLKVLATGGVGTNVAIWPKVPIDFYPMDLTLNELYLTASMDYTKIDFELVVKAFETGLIDPKEAAKLVSKKVPLRDGIEHGILDLINNKEKYIKILLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTC9</accession>
    <name>A0A1D8PTC9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 19, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR06820WA</name>
        <name evidence="1" type="ordered locus">orf19.9410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711081.2">
        <property type="nucleotide sequence ID" value="XM_705989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTC9"/>
    <dbReference type="FunCoup" id="A0A1D8PTC9">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="GeneID" id="3647325"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06820WA"/>
    <dbReference type="CGD" id="CAL0000192119">
        <property type="gene designation" value="orf19.9410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06820W_A"/>
    <dbReference type="eggNOG" id="ENOG502SBEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTC9"/>
    <dbReference type="OrthoDB" id="5554402at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019419">
        <property type="entry name" value="AIM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10315">
        <property type="entry name" value="Aim19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000192119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18481" checksum="16C34BC7F095CAFD" modified="2017-01-18" version="1">MAINFSSISIKPTWTYHNYPPINKMAQPQTNSIYDSIDKLSVSPIPAAALGGSLVLKGLFGTNATPVNVGATGGTGSAFKLGRKVALARPTRLSCFTFGGASLLGAWMMYDGDPVNASGFNFAWSALYLIVNGKESISGIFKGRITPLGLGGLALFNTGLYGREFFWSKNSPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTF7</accession>
    <name>A0A1D8PTF7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">HGT16</name>
        <name evidence="13" type="ordered locus">CAALFM_CR07270CA</name>
        <name evidence="12" type="ordered locus">orf19.13560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712348.2">
        <property type="nucleotide sequence ID" value="XM_707255.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTF7"/>
    <dbReference type="SMR" id="A0A1D8PTF7"/>
    <dbReference type="STRING" id="237561.A0A1D8PTF7"/>
    <dbReference type="GeneID" id="3646026"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07270CA"/>
    <dbReference type="CGD" id="CAL0000180854">
        <property type="gene designation" value="HGT16"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07270C_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTF7"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000180854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW31422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="565" mass="62805" checksum="1D1A819917585BD1" modified="2017-01-18" version="1">MLIDNKKLNLLETQTTNTEKELQEVDGEDEISYDTEDLSAPPTPSTIYNWRIVIIAITASFAAVIVGYDAGFIGGTVSLASFQGEFKMNELSPSQKTEINSNVVSVFQAGAFFGALFFYPIGEIWGRKLGLILSAFLLVFGAGISLEAKHSTGLASIYAGRVITGLGVGGCSGMAPIYISECSPAKIRGKLVGMWEMSWQIGGIVGYWINYGVLQNLPPSRKQWLIPFAIQLIPSGVFFIGTIFIPESPRFLVYKGQIDKAKVNLSQLRSIPTDHPYSVYEMENIIKDVEDKKSKLANDGFFAPILKLFLSKKLLYRLLLSTSLFPMQNGAGINAITYYSPAIFASFGITGSKAGLLSTGIFGILKAFAALVWMFCIVDRLGRRTALIYFSFPCSICMWYIGAYIKIAKPGLRVANGDTHQDAGGKAAQAMLYIWTIFYGSSWNGTPWVINSEIFSQEVRTLTQAINSMSNWFWAFIMGRFSGEAVKAIGYKFYFIFATCMAVFPIVIFFLYPETKGVPLEAVDYLFEVPAWRARPYAMAKYQKEYQKQNLSTSIPEEQLEKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTH8</accession>
    <name>A0A1D8PTH8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR07500WA</name>
        <name evidence="2" type="ordered locus">orf19.10151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710393.2">
        <property type="nucleotide sequence ID" value="XM_705301.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTH8"/>
    <dbReference type="GeneID" id="3647997"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07500WA"/>
    <dbReference type="CGD" id="CAL0000181546">
        <property type="gene designation" value="orf19.10151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07500W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PTH8"/>
    <dbReference type="OrthoDB" id="4027761at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000181546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="228" mass="26283" checksum="B0F18E3FFFF7D9A9" modified="2017-01-18" version="1">MYGRSRGYGGYRSGYGSSPYEYGSSSSYGRTGSSSNKYNKQTYPKSSQQQQQQGAPTYKQTSYKPQYAKQTYSQTPSSQQYAQADRGKSKNYKPTTPSNQYKKKTVNKTINVNQQPRRSRWGLGGFRSMWHIPMIFMFWREFSRNRHQPQPQPQPQPQQNEPINITNINYPSSPENATAPVQHSQPNTNNTEQSLPSSSQNIKPKQDENHSVFLYHSAEEEKEVDSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTW0</accession>
    <name>A0A1D8PTW0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">PEX13</name>
        <name evidence="17" type="ordered locus">CAALFM_CR08870WA</name>
        <name evidence="16" type="ordered locus">orf19.7282</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716417.1">
        <property type="nucleotide sequence ID" value="XM_711324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTW0"/>
    <dbReference type="SMR" id="A0A1D8PTW0"/>
    <dbReference type="FunCoup" id="A0A1D8PTW0">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTW0"/>
    <dbReference type="GeneID" id="3641877"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08870WA"/>
    <dbReference type="CGD" id="CAL0000182663">
        <property type="gene designation" value="PEX13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08870W_A"/>
    <dbReference type="eggNOG" id="KOG3875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTW0"/>
    <dbReference type="OMA" id="EGWFPKK"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000182663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW31557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="371" mass="39878" checksum="085C58927E500FCC" modified="2017-01-18" version="1">MSSSQPRTKPWEVSQGKSAASTTEPLTSNIPPSSLSNSSTTATAQGQPQSQIQPPSVPELPTSLSSDLNTMAESSPYGGYGNSSMNRYGTTGGYGSSMYGGGYGSSMYGNSMYGGGYGSSMYGGGYGGYGSGYGGYGSYGSGMYGGGMYGNNPSMMGQGGLGEGTQATFQLIESIIGAVGGFAQMLEATYMATHSSFFTMVNLAEQFGNLKNALGSILGIFALIKFVKKIFYKITGRVYNYGINASEFTKFEKNQKKLEENLRRNQSGQKPRISLKPLVLFLVAAVGFPYLLSKAIKLIEEKNQRPPPVPSKIQFARALYEFNPQNPQVEAPLEPKEIVAILDSRDNWLRIRKRSGTMGWVPSNYVEVIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTY6</accession>
    <name>A0A1D8PTY6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">PRE8</name>
        <name evidence="10" type="ordered locus">CAALFM_CR09380WA</name>
        <name evidence="9" type="ordered locus">orf19.7335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331114.1">
        <property type="nucleotide sequence ID" value="XM_019475569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTY6"/>
    <dbReference type="SMR" id="A0A1D8PTY6"/>
    <dbReference type="FunCoup" id="A0A1D8PTY6">
        <property type="interactions" value="1111"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTY6"/>
    <dbReference type="GeneID" id="3641906"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09380WA"/>
    <dbReference type="CGD" id="CAL0000197498">
        <property type="gene designation" value="PRE8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09380W_A"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTY6"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="251" mass="27742" checksum="97B46DBCF396681A" modified="2017-01-18" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVRQGVTAIGIKCGNGVVLATERKANSPLIRNDTNIKVEYITPNIGMTYSGMGPDFRVLVDRARKLAHTNYKRIYNEYPPVKIMVQEIAKVMQESTQSGGIRPFGVSLLVGGYDESNEGKFQLYQVDPSGSYFPWKATAIGKSSNSAKTFLEKRWNDNLQLEDGIHVALLALKECIDGELNGDNLDIAIISDPQEQLLGFKGTDIPGPRFKKLSPEEINDTLDSL</sequence>
</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="326" mass="35791" checksum="87822178F111EBF1" modified="2017-01-18" version="1">MATTPEVTYSNDRRNHPRNRFAWVKRLMQGQNRTTSMNNHTNRRTSSNNTSNNNEDATHNNNNNNYTNGNRSRHSNRQSRNKLVSNKNRDKIPKTEVVIESHDNNPIQSQSVQENNNIDNDEQDEGEERNSLDVMSDQISDNVSTTPLKSIVSSQSTKSPSILSGDAHNDQTSLIASTAETSLAPSVQTPTNYTFLPIITASLTNTTSSSSTTTTTTTTTTTTNNNNNATTNNNNNNNTILPVTYNASIGGQDRDSESIVTLASSTRRIRRRSIDTNCSTTGIPPASIMERLSVHPGNGGTNASTYANSIKTSNDDQSFFEESRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU01</accession>
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            <fullName evidence="10">Vacuolar membrane protein</fullName>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW31615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_706212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU01"/>
    <dbReference type="FunCoup" id="A0A1D8PU01">
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    <dbReference type="GeneID" id="3647098"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09570WA"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09570W_A"/>
    <dbReference type="eggNOG" id="KOG1944">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <location>
            <begin position="243"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31615.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="34240" checksum="C8F1975870F1B762" modified="2017-01-18" version="1">MPIRLVDYNEDNDSDDYDTTTSRRTTDFELLSNNNINITTDKPFMVRLINSIRCFNIPLINFIILLILIIFLIKLTTKYTNLYMKNSLITIIVTNLVLYGISETLAQSILIYRHDQPMISFKLREEIRLEDEDEDEDEDEEREEIGDPTIELTYFQFNRLAGFMCWGFIMGFFQCLWYKFLQIYSIPQDPKFIEVLRKVMTDQFLFSPISLFCFFTFGTIILEDKTWNDTVNKLKRIYLKTLIINYTVWFPIQFFNFLIIPRDYQVPFSSSISVLWNCYLSMRNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU46</accession>
    <name>A0A1D8PU46_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">SIK1</name>
        <name evidence="11" type="ordered locus">CAALFM_CR09950CA</name>
        <name evidence="10" type="ordered locus">orf19.7569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719331.1">
        <property type="nucleotide sequence ID" value="XM_714238.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PU46"/>
    <dbReference type="SMR" id="A0A1D8PU46"/>
    <dbReference type="FunCoup" id="A0A1D8PU46">
        <property type="interactions" value="1497"/>
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    <dbReference type="STRING" id="237561.A0A1D8PU46"/>
    <dbReference type="GeneID" id="3638925"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09950CA"/>
    <dbReference type="CGD" id="CAL0000178436">
        <property type="gene designation" value="SIK1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_09950C_A"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PU46"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
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    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
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        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
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    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
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    <dbReference type="InterPro" id="IPR002687">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
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    <dbReference type="PANTHER" id="PTHR10894">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="9">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000178436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="516" mass="57770" checksum="8879F9CFBE34F465" modified="2017-01-18" version="1">MPGLDYLLFEEATGYGIFKVLIQQDDIASRSKEVQEAANDLSKFSKMVELVSFAPFKGAAQALENANDISEGLVSPYLQSILELNLPKTSSKKRIALGVSDKNLGPSIKEVFPNVDVLSNEIVQDFLRGIRVHGAKLFKDLQEGDIERAQLGLGHAFSRAKVKFSVQKNDNHIIQAIALLDQLDKDINTFAMRVKEWYGWHFPELAKIVPDNYSYAKLALSIKDKASLTDDSLHDVAAILNDDSGLAQRVIDNAKISMGQDISEQDMDNVITFAQRVVNLYEYRQQLYKYLTDKMHTVAPNLSTLIGEVVGARLISHAGSLTNLSKQAASTVQILGAEKALFRALKTKGNTPKYGLIYHSSFIGKASAKNKGRISRYLANKCSIASRIDNYSEEPTTAFGEILKKQVEDRLKFYDTGSAPMKNSDAIKAALALNGQDLAGAEEQKDVDMVSDEEQVKKEKKEKKEKKEKKDKKEKKEKKDKKEKKDKKEKKDKKDKKRKSDDGEETPKKKKKKSKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>P82610</accession>
    <accession>A0A1D8PS13</accession>
    <accession>Q5A9B4</accession>
    <name>METE_CANAL</name>
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            <fullName evidence="5 6 7">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="2 3 4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6 7">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Methionine synthase, vitamin-B12 independent isozyme</fullName>
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    <gene>
        <name evidence="5 6" type="primary">MET6</name>
        <name type="ordered locus">CAALFM_CR01620CA</name>
        <name type="ORF">CaO19.10083</name>
        <name type="ORF">CaO19.2551</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Proteomics" volume="1" first="550" last="559">
            <title>Analysis of the serologic response to systemic Candida albicans infection in a murine model.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Diez-Orejas R."/>
                <person name="Molero G."/>
                <person name="Pardo M."/>
                <person name="Sanchez M."/>
                <person name="Gil C."/>
                <person name="Nombela C."/>
            </authorList>
            <dbReference type="PubMed" id="11681208"/>
            <dbReference type="DOI" id="10.1002/1615-9861(200104)1:4&lt;550::AID-PROT550&gt;3.3.CO;2-N"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 2-15</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="Electrophoresis" volume="21" first="2651" last="2659">
            <title>Cross-species identification of novel Candida albicans immunogenic proteins by combination of two-dimensional polyacrylamide gel electrophoresis and mass spectrometry.</title>
            <authorList>
                <person name="Pardo M."/>
                <person name="Ward M."/>
                <person name="Pitarch A."/>
                <person name="Sanchez M."/>
                <person name="Nombela C."/>
                <person name="Blackstock W."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="10949142"/>
            <dbReference type="DOI" id="10.1002/1522-2683(20000701)21:13&lt;2651::AID-ELPS2651&gt;3.3.CO;2-V"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 411-421</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="6">
        <citation type="journal article" date="2011" name="Arch. Biochem. Biophys." volume="513" first="19" last="26">
            <title>Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.</title>
            <authorList>
                <person name="Ubhi D."/>
                <person name="Kavanagh K.L."/>
                <person name="Monzingo A.F."/>
                <person name="Robertus J.D."/>
            </authorList>
            <dbReference type="PubMed" id="21689631"/>
            <dbReference type="DOI" id="10.1016/j.abb.2011.06.002"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF MUTANTS ALA-103/ALA-104/ALA-107; THR-103/THR-104/THR-107 AND TYR-103/TYR-104/TYR-107 AND IN COMPLEXES WITH ZINC</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>PATHWAY</scope>
        <scope>MUTAGENESIS OF LYS-103; LYS-104 AND GLU-107</scope>
    </reference>
    <reference evidence="12 13 14" key="7">
        <citation type="journal article" date="2014" name="J. Mol. Biol." volume="426" first="1839" last="1847">
            <title>Structural analysis of a fungal methionine synthase with substrates and inhibitors.</title>
            <authorList>
                <person name="Ubhi D."/>
                <person name="Kago G."/>
                <person name="Monzingo A.F."/>
                <person name="Robertus J.D."/>
            </authorList>
            <dbReference type="PubMed" id="24524835"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2014.02.006"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEXES WITH 5-METHYLTETRAHYDROFOLATEGLUTAMATE; L-HOMOCYSTEINE; L-METHIONINE; METHOTREXATE INHIBITOR AND ZINC</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
        <scope>MUTAGENESIS OF ASN-126 AND TYR-660</scope>
    </reference>
    <reference evidence="17" key="8">
        <citation type="journal article" date="2015" name="J. Mol. Biol." volume="427" first="901" last="909">
            <title>The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation.</title>
            <authorList>
                <person name="Ubhi D.K."/>
                <person name="Robertus J.D."/>
            </authorList>
            <dbReference type="PubMed" id="25545590"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2014.12.014"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.98 ANGSTROMS) IN COMPLEX WITH 5-METHYLTETRAHYDROFOLATEGLUTAMATE; L-HOMOCYSTEINE AND ZINC</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>PATHWAY</scope>
        <scope>ACTIVE SITE</scope>
        <scope>REACTION MECHANISM</scope>
        <scope>MUTAGENESIS OF MET-119; LYS-121; HIS-128; GLN-451; ARG-456; ARG-459 AND HIS-707</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3 4">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Inhibited weakly by methotrexate.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">25 uM for homocysteine (at 37 degrees Celsius)</KM>
            <KM evidence="3">87 uM for 5-methyltetrahydrofolate-triglutamate (at 37 degrees Celsius)</KM>
            <text evidence="3">kcat is 25 min(-1) for homocysteine. kcat is 29 min(-1) for 5-methyl-tetrahydrofolate-triglutamate.</text>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="2 3 4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="2 3 4"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718219.1">
        <property type="nucleotide sequence ID" value="XM_713126.2"/>
    </dbReference>
    <dbReference type="PDB" id="3PPC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="3PPF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="3PPG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.98 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="3PPH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="4L5Z">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.18 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="4L61">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.13 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="4L64">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.18 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="4L65">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.31 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="4L6H">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.75 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="4L6O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.88 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDB" id="4QQU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.98 A"/>
        <property type="chains" value="A=1-767"/>
    </dbReference>
    <dbReference type="PDBsum" id="3PPC"/>
    <dbReference type="PDBsum" id="3PPF"/>
    <dbReference type="PDBsum" id="3PPG"/>
    <dbReference type="PDBsum" id="3PPH"/>
    <dbReference type="PDBsum" id="4L5Z"/>
    <dbReference type="PDBsum" id="4L61"/>
    <dbReference type="PDBsum" id="4L64"/>
    <dbReference type="PDBsum" id="4L65"/>
    <dbReference type="PDBsum" id="4L6H"/>
    <dbReference type="PDBsum" id="4L6O"/>
    <dbReference type="PDBsum" id="4QQU"/>
    <dbReference type="AlphaFoldDB" id="P82610"/>
    <dbReference type="SMR" id="P82610"/>
    <dbReference type="BioGRID" id="1223094">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="P82610">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P82610"/>
    <dbReference type="EnsemblFungi" id="CR_01620C_A-T">
        <property type="protein sequence ID" value="CR_01620C_A-T-p1"/>
        <property type="gene ID" value="CR_01620C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640084"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01620CA"/>
    <dbReference type="CGD" id="CAL0000186137">
        <property type="gene designation" value="MET6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01620C_A"/>
    <dbReference type="eggNOG" id="KOG2263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="InParanoid" id="P82610"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="BRENDA" id="2.1.1.14">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="P82610"/>
    <dbReference type="PRO" id="PR:P82610"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019280">
        <property type="term" value="P:L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000098702" description="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase">
        <location>
            <begin position="2"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 16 17">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 13 15">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 16 17">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 13 15">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 17">
        <location>
            <begin position="530"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 16 17">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 13 15">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11 12">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11 12">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13 14">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11 12">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="No effect on catalytic activity; when associated with A-104 and A-107, or with T-104 and T-107, or with Y-104 and Y-107." evidence="2">
        <original>K</original>
        <variation>Y</variation>
        <variation>A</variation>
        <variation>T</variation>
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect on catalytic activity; when associated with A-103 and A-107, or with T-103 and T-107, or with Y-103 and Y-107." evidence="2">
        <original>K</original>
        <variation>Y</variation>
        <variation>A</variation>
        <variation>T</variation>
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect on catalytic activity; when associated with A-103 and A-104, or with T-103 and T-104, or with Y-103 and Y-104." evidence="2">
        <original>E</original>
        <variation>Y</variation>
        <variation>A</variation>
        <variation>T</variation>
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="22% of the catalytic activity of the wild-type." evidence="4">
        <original>M</original>
        <variation>A</variation>
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Less than 5% of the catalytic activity of the wild-type." evidence="4">
        <original>K</original>
        <variation>A</variation>
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of catalytic activity." evidence="3">
        <original>N</original>
        <variation>A</variation>
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="26% of the catalytic activity of the wild-type." evidence="4">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Less than 5% of the catalytic activity of the wild-type." evidence="4">
        <original>Q</original>
        <variation>A</variation>
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="38% of the catalytic activity of the wild-type." evidence="4">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Less than 5% of the catalytic activity of the wild-type." evidence="4">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of catalytic activity." evidence="3">
        <original>Y</original>
        <variation>A</variation>
        <variation>Q</variation>
        <location>
            <position position="660"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect on catalytic activity." evidence="3">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="660"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Less than 5% of the catalytic activity of the wild-type." evidence="4">
        <original>H</original>
        <variation>A</variation>
        <variation>K</variation>
        <location>
            <position position="707"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="8" ref="4">
        <original>S</original>
        <variation>D</variation>
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="strand" evidence="23">
        <location>
            <begin position="3"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="helix" evidence="23">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="strand" evidence="21">
        <location>
            <begin position="28"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="helix" evidence="23">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="strand" evidence="23">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="helix" evidence="23">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="helix" evidence="23">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="helix" evidence="23">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="strand" evidence="23">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="strand" evidence="20">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="strand" evidence="23">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="strand" evidence="23">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="strand" evidence="23">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="helix" evidence="23">
        <location>
            <begin position="144"/>
            <end position="146"/>
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<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>P87219</accession>
    <accession>A0A1D8PMK2</accession>
    <accession>Q5A1C3</accession>
    <name>SOU1_CANAL</name>
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            <fullName>Sorbose reductase SOU1</fullName>
            <ecNumber evidence="3">1.1.1.289</ecNumber>
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            <fullName>Sorbitol utilization protein SOU1</fullName>
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        <name type="primary">SOU1</name>
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        <name type="ORF">CaO19.10414</name>
        <name type="ORF">CaO19.2896</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Proc. Natl. Acad. Sci. U.S.A." volume="95" first="5150" last="5155">
            <title>Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans.</title>
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                <person name="Janbon G."/>
                <person name="Sherman F."/>
                <person name="Rustchenko E."/>
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            <dbReference type="PubMed" id="9560244"/>
            <dbReference type="DOI" id="10.1073/pnas.95.9.5150"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
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            <strain>SOR17</strain>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Yeast" volume="22" first="957" last="969">
            <title>Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.</title>
            <authorList>
                <person name="Greenberg J.R."/>
                <person name="Price N.P."/>
                <person name="Oliver R.P."/>
                <person name="Sherman F."/>
                <person name="Rustchenko E."/>
            </authorList>
            <dbReference type="PubMed" id="16134116"/>
            <dbReference type="DOI" id="10.1002/yea.1282"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Yeast" volume="22" first="1171" last="1171">
            <authorList>
                <person name="Greenberg J.R."/>
                <person name="Price N.P."/>
                <person name="Oliver R.P."/>
                <person name="Sherman F."/>
                <person name="Rustchenko E."/>
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            <dbReference type="DOI" id="10.1002/yea.1310"/>
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        <scope>ERRATUM OF PUBMED:16134116</scope>
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    <comment type="function">
        <text evidence="3">Catalyzes the NADP dependent reduction of L-sorbose to D-glucitol. Can also convert fructose to mannitol, but less efficiently.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-sorbitol + NADP(+) = keto-L-sorbose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14609"/>
            <dbReference type="ChEBI" id="CHEBI:13172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17924"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.289"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">3.95 uM for sorbose</KM>
            <Vmax evidence="3">378.0 umol/min/mg enzyme with sorbose as substrate</Vmax>
            <Vmax evidence="3">74.0 umol/min/mg enzyme with fructose as substrate</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="3">Optimum pH is 6.2.</text>
        </phDependence>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; L-sorbose degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    <dbReference type="EnsemblFungi" id="C4_06390W_A-T">
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        <property type="gene ID" value="C4_06390W_A"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C406390WA"/>
    <dbReference type="CGD" id="CAL0000190633">
        <property type="gene designation" value="SOU1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C4_06390W_A"/>
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    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
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    <keyword id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="281"/>
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        </location>
    </feature>
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        <location>
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        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
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            <name>NADP(+)</name>
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        </ligand>
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        </ligand>
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        </location>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16134116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="281" mass="30038" checksum="8D5A1F54B7259F19" modified="1997-07-01" version="1">MSEEIISFTNPALGPLPTKAPQLPSNVLDLFSLKGKVASVTGSSGGIGWAVAEAFAQAGADVAIWYNSKPADAKAEYLTEKYGVKAKAYKCNVTDPNDVSKVINEIEKDFGTIDIFVANAGVAWTDGPEIDVQGYDQWKKIVDCDLNGVYYCAHTVGQIFKKNKSGSLIITSSMSGTIVNIPQLQAPYNAAKAACTHLAKSLSVEWASFGARVNSISPGYILTDIADFADPEMKKKWWQLTPLGREGLPQELVGAYLYLASNASTYTTGSNIAVDGGYTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q59L46</accession>
    <name>Q59L46_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
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        <name evidence="3" type="ordered locus">orf19.9473</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705390.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.Q59L46"/>
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        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="3647914"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200060CA"/>
    <dbReference type="CGD" id="CAL0000180180">
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SBSE">
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
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        <property type="entry name" value="Say1-like"/>
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        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971187" description="Alpha/beta hydrolase fold-3 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000180180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43225" checksum="44988DB8EED27C92" modified="2005-04-26" version="1">MHGTMITIDFFLKLVTLPYTVTKTVLQYYTVGTPYSRTNQEFRNSLWKNVLLSVQYHVSGNYKKENIKAVIYQPIDKVIAKFKTHPLASGLAHFGEKFDEYSYWIHKADTQGKVLIYIHGGGYLLNMFESQFVFVSALHYALDDHAAENTSILVVDYSLTMFDNVYPTQLYEHLVTYNNLVAQGYKDILLLGDSAGAHMSLSLARAIAYPEEAKQQLQQYNVSLDLPQPQALILVSPWVQPCTTPKLPPRHGCDVWGDLGAQDTSMGELYAGDNDKSFINNFLTFTNTNWDEHWKEVEALNGNTLMIVGEREVLRDGVDDFYNIIKGGVEYYTEPGGIHAGLVYVECLDYISKQGAERAIKGDFKDKFAYNLVAKFINERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LZ5</accession>
    <accession>Q3MP84</accession>
    <name>Q59LZ5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">TOM70</name>
        <name evidence="15" type="ordered locus">CAALFM_C702640WA</name>
        <name evidence="14" type="ordered locus">orf19.11184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710749.1">
        <property type="nucleotide sequence ID" value="XM_705657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LZ5"/>
    <dbReference type="SMR" id="Q59LZ5"/>
    <dbReference type="FunCoup" id="Q59LZ5">
        <property type="interactions" value="810"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LZ5"/>
    <dbReference type="GeneID" id="3647645"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702640WA"/>
    <dbReference type="CGD" id="CAL0000178541">
        <property type="gene designation" value="TOM70"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02640W_A"/>
    <dbReference type="eggNOG" id="KOG0547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017516_1_0_1"/>
    <dbReference type="InParanoid" id="Q59LZ5"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000357">
        <property type="entry name" value="Mitochondrial proteins import receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000374">
        <property type="entry name" value="Mitochondrial proteins import receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000178541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW30619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="629" mass="69680" checksum="0E08E41DF9F4D2C9" modified="2005-04-26" version="1">MSSDNFFIKNRTAIIVTALTAFSAAGAYYYYTQQQSTGGSNSSSKSNKSSSEEGNTSTSSSSSKKKKKSKKSKGSATPEPTNSTSSSTTTTTTTTTTSSSDSKSTSSKKIKYPINSEGLPELTSDIISKLSETEKEEWAMQLKEDGNQEFKNKNFKKAIEFYSAALELKQDPIYYSNRSACYAALDDHENVIKDTTEAINLKPDYTKCILRRATSFEVLEKYEDAMFDLTALTIYGGFSNKSIEQVLERVLRKHSIKIVESKPKKLILPSAATIGSFFGAFVEETEPEGINESHENEGVKALYTALQKINANTQNGYEEADELISKAVTELESAIESATELKPVLAIALEYLAAFQFLKNDPVSAAESIEKAISLKPRPRAYVFRALINADKSSYEAALKDFKTAEELDDKCPDIFYHLGQLFYLTGDLTNAEINFNKAKELHPDNVYAYIQLACITYKNGQIELANEKFTEAKLKFPTSPEVPNYYGEILADKGDIQGACKQFEIASRLQEKLDRFSVGALPLINEATVISRESLEKIGEAEELLTKACALDPKSELARISLAQIKLQKDEVDDAIVLFEESSDLARSIEEKIQATSFAEATKMQKRIKNDPILNNKIAELMRQSGAM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-04-09" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q59N20</accession>
    <accession>A0A1D8PSW0</accession>
    <accession>Q59N03</accession>
    <name>MSS11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcription activator MSS11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MSS11</name>
        <name type="ordered locus">CAALFM_CR04840CA</name>
        <name type="ORF">CaO19.13686</name>
        <name type="ORF">CaO19.6309</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1780" last="1791">
            <title>Mss11, a transcriptional activator, is required for hyphal development in Candida albicans.</title>
            <authorList>
                <person name="Su C."/>
                <person name="Li Y."/>
                <person name="Lu Y."/>
                <person name="Chen J."/>
            </authorList>
            <dbReference type="PubMed" id="19734367"/>
            <dbReference type="DOI" id="10.1128/EC.00190-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FLO8</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with FLO8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MSS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711094.2">
        <property type="nucleotide sequence ID" value="XM_706002.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59N20"/>
    <dbReference type="SMR" id="Q59N20"/>
    <dbReference type="BioGRID" id="1230377">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59N20"/>
    <dbReference type="EnsemblFungi" id="CR_04840C_A-T">
        <property type="protein sequence ID" value="CR_04840C_A-T-p1"/>
        <property type="gene ID" value="CR_04840C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647296"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04840CA"/>
    <dbReference type="CGD" id="CAL0000199904">
        <property type="gene designation" value="MSS11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04840C_A"/>
    <dbReference type="eggNOG" id="ENOG502S549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027504_0_0_1"/>
    <dbReference type="InParanoid" id="Q59N20"/>
    <dbReference type="OrthoDB" id="4036671at2759"/>
    <dbReference type="PHI-base" id="PHI:4220"/>
    <dbReference type="PRO" id="PR:Q59N20"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900442">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000333383" description="Transcription activator MSS11">
        <location>
            <begin position="1"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="LisH" evidence="2">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19734367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="638" mass="72255" checksum="DFE974C892BFEC31" modified="2017-03-15" version="2">MSKPPPQHQSKNANNSLSSPVSDKQSNDSRQLLLAHLYNYFKTNGLEETAQALLIECNNTIPKATTNSKGYSLDNSGPDQKDTFLDQWWGLLWSIQSSINPNLNQMTNPSGILTPQHQMIVQQRMLQQQQQQAQQQQQQAQQQQAQQQQQQQQLLQQQRLQQQAMIQQQHQQQLINNLSARQQQVGLSTTTNQMGPPGSNSNNLQSNMSPNNEQLQSQARLQQLKLQFQQQQQQQLQQQQQQLQLQQQQQQQQQQQQQQQQQQQQQQRQQQRQRQKKFQRQLSTSSQKSPVINNGQPQQQLQQDQRPASAPQNQPTPGNNNNNNNNTNAVSPKLHRQSVDDYQMNLLQMENQNNSQRQKYLNNQQTRNSQQQQQQQQSQSQSQQSSPFQPPAQQPKNSTTTSTNTTTSRAQKSSRKQQPKNSRRQSVQQQQQQQPQQQPQQSQQMSTSSQSFTAANNSNNVNNTFDISPQIQDQGMLSTKEQQQQPQQPQPQPQSQPQSQSQSLPSNNNNNNNNKQDVVNVVFDDAFFSGNLLLDDFNEFANSTSNNGNGNGNNDMNSQFNNTQTERIMFSMPPNQNQNQFPSQSGDGGGGGGGSMQPNFFEGIELGDGNNSGNGDDDDAPIITTDWLSSMGSGPGYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-08" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NQ9</accession>
    <accession>A0A1D8PN60</accession>
    <name>FYV7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FYV7</name>
        <name type="ordered locus">CAALFM_C501480WA</name>
        <name type="ORF">CaO19.11619</name>
        <name type="ORF">CaO19.4143</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the processing of the 20S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FYV7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NQ9"/>
    <dbReference type="SMR" id="Q59NQ9"/>
    <dbReference type="FunCoup" id="Q59NQ9">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59NQ9"/>
    <dbReference type="EnsemblFungi" id="C5_01480W_A-T">
        <property type="protein sequence ID" value="C5_01480W_A-T-p1"/>
        <property type="gene ID" value="C5_01480W_A"/>
    </dbReference>
    <dbReference type="KEGG" id="cal:CAALFM_C501480WA"/>
    <dbReference type="CGD" id="CAL0000198911">
        <property type="gene designation" value="FYV5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01480W_A"/>
    <dbReference type="eggNOG" id="KOG4851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105541_0_0_1"/>
    <dbReference type="InParanoid" id="Q59NQ9"/>
    <dbReference type="OMA" id="MGPKIDD"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="PRO" id="PR:Q59NQ9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017265">
        <property type="entry name" value="Fyv7_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037708">
        <property type="entry name" value="rRNA_proc_FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000087399" description="rRNA-processing protein FYV7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="142" mass="16786" checksum="34FC3EC1FA0E5CAE" modified="2005-04-26" version="1">MHPNNKNSFKSKKKFIDRREAKSQDIKRALTHRARLRKNYFKLLEKEGLQEEGKPEDENDIRPTKKKGINFEERAAIVKQRKEEKRKFKLASVQAKLEKIESNSKERALKREQLKKSTTKGQPLMGPRINDLLDKIKKNEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P56</accession>
    <name>Q59P56_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Threonine dehydratase</fullName>
            <ecNumber evidence="14">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">ILV1</name>
        <name evidence="17" type="ordered locus">CAALFM_C206190WA</name>
        <name evidence="16" type="ordered locus">orf19.12935</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="14"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711472.1">
        <property type="nucleotide sequence ID" value="XM_706380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P56"/>
    <dbReference type="SMR" id="Q59P56"/>
    <dbReference type="FunCoup" id="Q59P56">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59P56"/>
    <dbReference type="GeneID" id="3646918"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206190WA"/>
    <dbReference type="CGD" id="CAL0000199398">
        <property type="gene designation" value="ILV1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06190W_A"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_1"/>
    <dbReference type="InParanoid" id="Q59P56"/>
    <dbReference type="OMA" id="TRFEYTK"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901705">
        <property type="term" value="P:L-isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="15">
        <location>
            <begin position="391"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="15">
        <location>
            <begin position="488"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000199398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW27627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="569" mass="63164" checksum="702C8EF67531C483" modified="2005-04-26" version="1">MSITRLSSAKLLLSSTSRKLQVLRLNSTTTKPLTPRQKWPELLDSDFIVNSQGEKQPDYVKLILTSRVYDVVDEAGTPLTNAINLSHRCGANIYLKREDLLPVFSFKLRGAYNMIAHLHSNSPQPISGVIACSAGNHAQGVAFSSSKLNIPATIVMPTPTPSIKYTNVSRLGAQVVLYGDDFDSAKQECERLSTEQNLINIPPFNHPYVIAGQGTIALEIARQLRLDKLNAIFVPVGGGGLIAGVAVYLKHIAPHVKIIGVETYDADALNQSLKNSRSVTLEKVGLFADGTAVKVLGDETWRLAKEYVDEVVLVNTDELCAAIKDIFEDTRSIVEPSGALSVAGLKKYIEEHPEIDHRDKTYVPVLSGANMNFDRLRFVSERAVLGEGKEVSLAVTIPEKPGEFARLQKVINPRAITEFSYRYNGEENADIFVSFNVVDKKKEKSSVIAAMENCGFEVVDISENELAKSHGRYLVGGKSQSTKSSNEKIYQFEFPEKPNALFNFLQALRSDWNISLFNYRNHGHDVGKILCAFTLPEGSEEDFQEFLKNVGYTFVDESDNIFYKKFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PZ5</accession>
    <name>Q59PZ5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone acetyltransferase GCN5</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">GCN5</name>
        <name evidence="19" type="ordered locus">CAALFM_CR06710CA</name>
        <name evidence="18" type="ordered locus">orf19.8324</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711778.1">
        <property type="nucleotide sequence ID" value="XM_706686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PZ5"/>
    <dbReference type="SMR" id="Q59PZ5"/>
    <dbReference type="FunCoup" id="Q59PZ5">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PZ5"/>
    <dbReference type="GeneID" id="3646626"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06710CA"/>
    <dbReference type="CGD" id="CAL0000180088">
        <property type="gene designation" value="GCN5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06710C_A"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015741_2_0_1"/>
    <dbReference type="InParanoid" id="Q59PZ5"/>
    <dbReference type="OMA" id="HQPPKEW"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="PHI-base" id="PHI:4561"/>
    <dbReference type="PHI-base" id="PHI:9284"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043993">
        <property type="term" value="F:histone H3K18 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000046">
        <property type="entry name" value="Histone acetyltransferase GCN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 14" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="115"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="16">
        <location>
            <begin position="359"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000180088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW31368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="449" mass="52156" checksum="2B41A0977F78CD43" modified="2005-04-26" version="1">MVDRKRTAAIRAEDDDEENDNVPLQKKVKIEAKQKEEEEDGDKSGATETKSEVKQESKEETTQKENNEEDEEEEEEEDDEEAEEEKKRITNFNFDGEIYTFKERPSVIEEKEGKIEFRVVNNDNSRENLIVLTGLKNIFQKQLPKMPREYISRLVYDRSHLSMAVVRKPLTVVGGITYRPFNNRGFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRATSPIKYFLTYADNYAIGYFKKQGFTKEISLDKSVWMGYIKDYEGGTLMQCSMLPSILRYLDSGKILLLQKAAIERKIRSRSKSKIVRPGLQVFKTNKNVTLDPKDIPGLAEAGWSEEMDKLAQKPKRGPHYNFMVTLFSEIQNHPSAWPFAVAVNKEEVPDYYRVIEHPIDLATIEQKLENNLYLKFTDFVDDLKLMFNNCRAYNSETTTYYKNANKLEKFMNNKLKDCSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q59R23</accession>
    <accession>Q3MNZ3</accession>
    <name>Q59R23_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C703640CA</name>
        <name evidence="9" type="ordered locus">orf19.13990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712150.1">
        <property type="nucleotide sequence ID" value="XM_707057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59R23"/>
    <dbReference type="SMR" id="Q59R23"/>
    <dbReference type="FunCoup" id="Q59R23">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59R23"/>
    <dbReference type="GeneID" id="3646223"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703640CA"/>
    <dbReference type="CGD" id="CAL0000182802">
        <property type="gene designation" value="orf19.13990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03640C_A"/>
    <dbReference type="eggNOG" id="KOG0554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="InParanoid" id="Q59R23"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070145">
        <property type="term" value="P:mitochondrial asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="157"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000182802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="489" mass="55432" checksum="5C16FB947E71FC01" modified="2005-04-26" version="1">MLIQSRFPLKALQQVSSKRFNSSSLNPTIKNQLSNPPPIGSIIEARGFVKSIRSSKKVGFVDITDGSISNNLNIVLQGPDQPKFKVGQSIVVKGDWTVGKGKQPFELKYNPENPQHAITILGDVTDDYPLQKKATSMSFLRNFPEIKHRTSTLGSFLRLRSHLEFKLMEFFQSRDFIKVTPPLITSSDCEGAGEVFKIEPLNDNNPKEPFFGKNAYLTVSTQLHLECLALALNRAWTLTPCFRAENSNTTRHLSEFWMLEAEISHVNNVDQVTTFTEDMIKFVTKSLVESSHSTELSDLGAGNGNDYLNGTYIEKDVVQSRWSNILSAERWPRMTYTEAIEYLNKTLPQDEQLIWGDSLQLKHERLLAEKSPIFITDYPESQKPFYMLKSANYNAENPTVACFDLLVPEFGELAGGSMREHDYQVLLANMKQENMNIEDMEWYLNLRKQGTIPHGGFGLGFERLISYLAGYDNVRDISAFPRAPELCNC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RF7</accession>
    <accession>A0A1D8PQH9</accession>
    <name>PFF1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane protease</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FXNA-related family protease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C604650WA</name>
        <name type="ORF">CaO19.2163</name>
        <name type="ORF">CaO19.9709</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712436.1">
        <property type="nucleotide sequence ID" value="XM_707343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RF7"/>
    <dbReference type="SMR" id="Q59RF7"/>
    <dbReference type="FunCoup" id="Q59RF7">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_04650W_A-T">
        <property type="protein sequence ID" value="C6_04650W_A-T-p1"/>
        <property type="gene ID" value="C6_04650W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645979"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604650WA"/>
    <dbReference type="CGD" id="CAL0000197151">
        <property type="gene designation" value="orf19.9709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04650W_A"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="InParanoid" id="Q59RF7"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="PRO" id="PR:Q59RF7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000411705" description="Vacuolar membrane protease">
        <location>
            <begin position="1"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="58"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="3">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="3">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="468"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="3">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
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    <sequence length="837" mass="93760" checksum="681DD49772E024B1" modified="2005-04-26" version="1">MSEEEVHDTSSEASEVFTNQPNAFVRGVRSIFGYRKTSLTLFVILTIVVTAGLSFYDNSLELTIELPTSQLEKEILESSWLDLQNIARYPHTYGSRANDQVHDYLEEIIQDMEYDNDGEKIMFESGKGVVSYYESNNLLVRVNGSDGTLPALLLSAHYDSVPSSFGVTDDGMGVASLLGVLRFVAHNQPRRTIIFNFNNNEEFGLFGAHAFVKHPWFKQVGYFLNLEGTGAGGKAVLFRGTDYGIVKNFGGVRYPYATSIFQQGFNNHVIHSETDYKVYKEAGLRGLDLAFYKPRDKYHTGEDNIRNVSPKSLWHMMSNAIDFVQMGVVDDSEEPAVYTTFLGYFFATPISALARVNLVLLVLFPVVSTPLLFVIVKYKKWKLRVTNFLGVPLAMGLAVAVGQVGNPMLVSSHPMMVVATTTSIVVLVYYVVLNGVDWVNTSSDQKLVTMIEVSFVYWVVLVYVTWSGGDHTGEFGVTVLFFVQASTSLLGLIGWTFTRVRGGDEPLLSGEEERYGTEDERDTEKPLVEHNYDWSLQYLLIVPVSSLVVYNSGWLVLEGVNKTVQESLASEHLIYWIVVVFSQFLVLPVVPFITKFNRYIVLGLSVVVVVGVLMSMAVHPFNQGSPMKLRFIERVGQNDMVEVYGRQGFVEDVLSDLPSVKQTQAKLECEALPDGLEVCKYKSGLTPGNLTVEVTTEPRAESYGLISGAITIAAPENRMCTVHFPPDRVKAVVVGKFGNNFKAIPDGFSREKGNYIYKDRNGISQLELYKLDWNKDYHVGFEWLPDIDDEGGMRVEVECFWGDMVPAYQEVVHYSPNWVTWANKERGLVGVVKHVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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        </subcellularLocation>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="757" mass="84005" checksum="237C30E78E76370F" modified="2005-04-26" version="1">MKRTPRSDTVSPDRSRLTSPSPSIRHISHTRVNTERSYLLHKDSTPQVADAESIIYQDEYTPANTHNVESLSWSEILPYYIPCLSWIGQYSVEFFVGDLIGGLSLVFFQLPLSLSYATSLAHVPVTSGLYSLGISPLIYLIFGSVPQMIVGPEAPISLIVGQAIEPLLHHAKKAHLDPVEYVVAITFVSGSTLLGFGLARFGFLDNVLSASLLKGFIAGVGIVMIITSSIIVLGLEKLMKQISDDPNEMDIHSPFDKVRFLIQYIGQRNQQSLNIGLVGFFIIFTIRLFKKHAAKQNGRLYKYAVFIPEIMLVVAGSTILCQHYRWDLGGLPVIGKVRNEGDFKFYNPLSLSNLHLIKKLCASGFMCAMLGFFESTTASKSLGSMYDLPISSNRELVALGSINIFGSVFGALPAFGGYGRSKVNAISAKTTMSGGIMGICTLLTIHFLLKYLYFVPQCMLSVVAAVIGISLIEEAPYELYFHWKTRGIDEIITFCVTVVTTLFFSMEGGIAVGIGYSLVRVVKNSTFSRIQILGRYPNTNKFVNADIPAYQTSQEKVAGSYLNLFDDAQHMQLNTQVLEEVEGCLIIKVPEPLTFTNCSDLTTRLKRVEMYGSTRAHPASKRSRDIGMTKYVIFDLKGMSSLDSTAAKILKTLLEGYRKRGIRTCFVRMSSDKHLRKMLADSGICKLLIDDLTDLKYFAIQEIAEQNSQPLTTPEMEAMVECYSLIESSSHPYFNHISDALKVIDCFETNYVDTIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SE2</accession>
    <name>Q59SE2_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Stb3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">STB3</name>
        <name evidence="3" type="ordered locus">CAALFM_C209010WA</name>
        <name evidence="2" type="ordered locus">orf19.7833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27889.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="503" mass="54844" checksum="F29B71E94429FB5A" modified="2005-04-26" version="1">MTSRSPISLASLMNDPTPPPQPQSQSQPRSQFPTTTTQTSMQQQSQEPSLQQSDSKKTLLSTSSPEGIQVASKITPTRLANLLIRKGPLPIRHITSQLALEVPSFELLSLSKQRRLIMAAMEQTDTVNNVVFEKIGWGQWAVRKIDSDYIVTEGTEKSSNANTSGSSGNGSANEKLINVNDLRNQSNLKLGWSKKKKSVSASAGAGSGAGLNSRRESITNHVKSLHNIKLPNESIDNAIASESSDDDDDDDQEGIDEYALSDTESSDEEMFAFDEKNRASSSVSNPITAISEHTVLGSPPIKFARRVPIKISPPPEVGAINGSGNMASSASRRRKSSSSVSNSITKPYRQHLFNTRSRLNSIENLDNYIVSSAKNSSVSISSPPPPISFSSSPATSVAYDEHYNLNQQQSSSFQQKLQQQQQQQKNQRRKSSFNESHVRSTLSNVKTSSDDTDEEDWAAMGPESLRKNRKNSIPAALRNDIDSSGVDEEEKSAAFALVDLMSV</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW28413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="175" mass="20362" checksum="5F26B42A3F40ACE3" modified="2005-04-26" version="1">MTLARYPKAVVFDLDYTLWPCWCDTHIMTPLKSVSPTTVVDRYDFQLSFYKDVESIIRELVENDVKIIAASRTATPHIAKQLLSMLHIQGRPAIEYFHSLQWGTGSKTKHIKAAAKNLKMTTELTDGEFILFDDEWRNRDVESINCHFAHVPDESVGLTRHIFVQELRQWNKRNL</sequence>
</entry>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="15123810"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713119.1">
        <property type="nucleotide sequence ID" value="XM_708026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59U89"/>
    <dbReference type="SMR" id="Q59U89"/>
    <dbReference type="FunCoup" id="Q59U89">
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    <dbReference type="STRING" id="237561.Q59U89"/>
    <dbReference type="GeneID" id="3645193"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207630CA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C2_07630C_A"/>
    <dbReference type="eggNOG" id="ENOG502S9SB">
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000176228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="121" mass="13139" checksum="70AEC26EAAF6559F" modified="2005-04-26" version="1">MAKTSPHKLFYKGAENDFVIFIDDADLLAKYKKEFSTKGSSTIPIIDLVSIFKVFINRQRGAEGILDEAAKSDLENEFKTSNADQVIKIILEKGEDKSKTGSIGEIGGSHNDSIGNGDAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VN4</accession>
    <name>Q59VN4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">HHF1</name>
        <name evidence="15 17" type="synonym">HHF22</name>
        <name evidence="16" type="ordered locus">CAALFM_C104240CA</name>
        <name evidence="17" type="ordered locus">CAALFM_CR06800CA</name>
        <name evidence="14" type="ordered locus">orf19.8661</name>
        <name evidence="15" type="ordered locus">orf19.9412</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314</strain>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314</strain>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314</strain>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2016-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Candida Genome Database"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">SC5314</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">SC5314</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711083.1">
        <property type="nucleotide sequence ID" value="XM_705991.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713663.1">
        <property type="nucleotide sequence ID" value="XM_708570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VN4"/>
    <dbReference type="SMR" id="Q59VN4"/>
    <dbReference type="FunCoup" id="Q59VN4">
        <property type="interactions" value="1386"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VN4"/>
    <dbReference type="GeneID" id="3644705"/>
    <dbReference type="GeneID" id="3647327"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104240CA"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06800CA"/>
    <dbReference type="CGD" id="CAL0000174606">
        <property type="gene designation" value="HHF1"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000199430">
        <property type="gene designation" value="HHF22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04240C_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06800C_A"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="OrthoDB" id="3972251at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071940">
        <property type="term" value="P:fungal-type cell wall assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="13">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000174606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000199430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="105" mass="11621" checksum="25D8E8EA6EC93854" modified="2005-04-26" version="1">MSGTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISALIYEEVRVVLKQFLENVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WU2</accession>
    <name>Q59WU2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="4 14">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C601050WA</name>
        <name evidence="15" type="ordered locus">orf19.7756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="4 14"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714317.1">
        <property type="nucleotide sequence ID" value="XM_709224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WU2"/>
    <dbReference type="SMR" id="Q59WU2"/>
    <dbReference type="FunCoup" id="Q59WU2">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WU2"/>
    <dbReference type="GeneID" id="3644015"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601050WA"/>
    <dbReference type="CGD" id="CAL0000176983">
        <property type="gene designation" value="orf19.7756"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01050W_A"/>
    <dbReference type="HOGENOM" id="CLU_024003_0_0_1"/>
    <dbReference type="InParanoid" id="Q59WU2"/>
    <dbReference type="OMA" id="FKLYCGA"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial tyrosyl-tRNA aminoacylation"/>
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    </dbReference>
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        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000176983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW30051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="501" mass="56194" checksum="58F9EF1A3CBCEF31" modified="2005-04-26" version="1">MLKTHTRNIPLIRRLARFNSTIARDPVTIIPTIYELTEAKDLTPETNPDNSLLEYLQSRHLIESITDDNLYKLTKRGSNHKFKLYCGADPTASSLHLGNLLPLMVLLHFKMSGNDVVGLVGGATGLVGDPSGRKTERNKIDEVEVEDNVTKIQRQISTFLSNGIEYAKSRQFPMTEKVGDTTSVNNASWWENVKMLEFLATYGRHIRVSSMLARDSIQSRLESGGIGFNEFTYQILQAYDFWHLYKDENVNMQVGGNDQWGNITAGIDLISRLKKFHGKKHEAYGLTVPLLTTSSGEKFGKSAGNAVFIDSSLTTPYQMYQYFINVPDDIVGKLLKVFTLLPLNVIEGELLPKHNSDPGLRIAQRVLAREVVDLIHGVGVGDEMAFITGFLFPTPDQPFNDNVSADKLIENFKRSGILFKRNKPSPDEEIKLSALLADIVGKSKGEMRRLIKAGGVYMGLDRNQIEDPDDVILFDVDNHLIDGKLLLVRVGKQNYYVVEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WW7</accession>
    <name>Q59WW7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPX31</name>
        <name evidence="10" type="ordered locus">CAALFM_C600850WA</name>
        <name evidence="9" type="ordered locus">orf19.7731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714295.1">
        <property type="nucleotide sequence ID" value="XM_709202.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WW7"/>
    <dbReference type="SMR" id="Q59WW7"/>
    <dbReference type="FunCoup" id="Q59WW7">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WW7"/>
    <dbReference type="PeroxiBase" id="5583">
        <property type="entry name" value="CalGPx02"/>
    </dbReference>
    <dbReference type="GeneID" id="3644010"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600850WA"/>
    <dbReference type="CGD" id="CAL0000196844">
        <property type="gene designation" value="GPX31"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00850W_A"/>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_1"/>
    <dbReference type="InParanoid" id="Q59WW7"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="PHI-base" id="PHI:4936"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000196844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="161" mass="18103" checksum="BCE795D5264A06A2" modified="2005-04-26" version="1">MSQFYELAPKDAKGEPYPFEQLKGKVVLIVNVASKCGFTPQYKGLEELNKKFADQPVQILGFPCNQFGHQEPGSNEEIGSFCSLNYGVTFPVLDKIEVNGDNTDPVYKYLKSQKSGVLGLTRIKWNFEKFLIDQNGKVIERFSSLTSPESIGTKIEELLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YC4</accession>
    <name>Q59YC4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">CCT2</name>
        <name evidence="11" type="ordered locus">CAALFM_C209520CA</name>
        <name evidence="10" type="ordered locus">orf19.8980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714573.1">
        <property type="nucleotide sequence ID" value="XM_709480.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YC4"/>
    <dbReference type="SMR" id="Q59YC4"/>
    <dbReference type="FunCoup" id="Q59YC4">
        <property type="interactions" value="1502"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YC4"/>
    <dbReference type="GeneID" id="3643815"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209520CA"/>
    <dbReference type="CGD" id="CAL0000197460">
        <property type="gene designation" value="CCT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09520C_A"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="Q59YC4"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="BRENDA" id="3.6.4.B10">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000197460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="526" mass="56807" checksum="1B17D122481AA0BD" modified="2005-04-26" version="1">MSVQIFNDQATEERAENARMSAFIGAIAVGDLVKSTLGPKGMDKLLQSSSNADHALVTNDGATILKSIPFDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQKIHPQTIIEGFRIACNVAIQALNKAAVNNGDNPTLFRNDLLNIAQTTLSSKILSQDKLLFSNLAVDAILRLKGSTNLNHIQIIKKVGGKLSDSYLDQGFILEKKFGIGQPKKITDAKILIANTSMDTDKVKIFGAKFKVDSTSKLAELEKAEKLKMKNKVDKIAKFGINVFINRQLIYDYPEQLFTDAKINSIEHADFDGVERLALVTGGEVVSTFDSPDNVKLGHCESIEEIIIGEDTFLKFSGVAAGEACTIVLRGATEQVLDEAERSLHDALSVLSQTTRETKTVLGGGCSEMLMAKAVDQAAANETGKSALAIEAFSRALRQLPTILADNAGYDSSDLVTKLRSAIYNGMSTSGLDLNHGIVADMREMGIVESYKLKKAVVSSAAEAAEVLLRVDNIIRAKPRTADRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YD1</accession>
    <name>Q59YD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C209590CA</name>
        <name evidence="15" type="ordered locus">orf19.8973</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714567.1">
        <property type="nucleotide sequence ID" value="XM_709474.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YD1"/>
    <dbReference type="SMR" id="Q59YD1"/>
    <dbReference type="FunCoup" id="Q59YD1">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YD1"/>
    <dbReference type="GeneID" id="3643800"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209590CA"/>
    <dbReference type="CGD" id="CAL0000177748">
        <property type="gene designation" value="orf19.8973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09590C_A"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_2_0_1"/>
    <dbReference type="InParanoid" id="Q59YD1"/>
    <dbReference type="OMA" id="PERAYAW"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="144"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="245"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000177748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="338" mass="36237" checksum="76B9C79E1A0EA28C" modified="2005-04-26" version="1">MAGNSLADSLTQPLNDQLKKATDKLTGGGSGGASSSSGGSKIKLFTPEYYAACTVGGIIACGPTHSAVTPLDLVKCRRQVNASIYKSNIQGWKTILKTQGDSIFTGIGATFIGYSFQGAGKYGFYEVFKKKYSDLVGPKVAQNYQTGIFLAASASAEFLADIALCPWETIKVKTQTTIPPYANSVFDGWKKIVATEGFGGLYKGLVPLWCRQIPYTMVKFASFENIVAGIYSYLGKPKSDYTNLQQTGVSFLGGYIAGIFCAIVSHPADVMVSKINNEKSPNESIGQAISKIYSKIGFAGLWNGLPVRIVMIGTLTGFQWLIYDSFKVYIGLPTTGGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0Y8</accession>
    <accession>A0A1D8PMQ2</accession>
    <name>MGMT_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber>2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName>MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA repair MTase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MGT1</name>
        <name type="ordered locus">CAALFM_C407010CA</name>
        <name type="ORF">CaO19.10620</name>
        <name type="ORF">CaO19.3108</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715417.1">
        <property type="nucleotide sequence ID" value="XM_710324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0Y8"/>
    <dbReference type="SMR" id="Q5A0Y8"/>
    <dbReference type="FunCoup" id="Q5A0Y8">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0Y8"/>
    <dbReference type="EnsemblFungi" id="C4_07010C_A-T">
        <property type="protein sequence ID" value="C4_07010C_A-T-p1"/>
        <property type="gene ID" value="C4_07010C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642966"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407010CA"/>
    <dbReference type="CGD" id="CAL0000196232">
        <property type="gene designation" value="orf19.10620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07010C_A"/>
    <dbReference type="eggNOG" id="KOG4062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_1"/>
    <dbReference type="InParanoid" id="Q5A0Y8"/>
    <dbReference type="OMA" id="YTFIETE"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="PRO" id="PR:Q5A0Y8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000333682" description="Methylated-DNA--protein-cysteine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="175" mass="19492" checksum="8D9B5BF2AD259EE7" modified="2005-04-26" version="1">MSNLYYTVFDTDVCTVLLVLTLNGFVCYASLGKPAIELKGIMAKDFSSLPYQLKPLSTMTGDKIEIDKSVEKFKLLVETPSVSQDIKTELLFGTPLQRKVWKELVKIPAGQTRTYKELADLLGTHSRVIGNCCGANRIAVLIPCHRVVGANNKLTGYRWGKSYKEYLLKQEGIGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2025-06-18" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A301</accession>
    <accession>A0A1D8PKI2</accession>
    <name>PREP_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Presequence protease, mitochondrial</fullName>
            <shortName>PreP</shortName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CYM1</name>
        <name type="ordered locus">CAALFM_C306230WA</name>
        <name type="ORF">CaO19.7410</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716075.1">
        <property type="nucleotide sequence ID" value="XM_710982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A301"/>
    <dbReference type="SMR" id="Q5A301"/>
    <dbReference type="BioGRID" id="1225338">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A301">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A301"/>
    <dbReference type="MEROPS" id="M16.013"/>
    <dbReference type="EnsemblFungi" id="C3_06230W_A-T">
        <property type="protein sequence ID" value="C3_06230W_A-T-p1"/>
        <property type="gene ID" value="C3_06230W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642244"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306230WA"/>
    <dbReference type="CGD" id="CAL0000201699">
        <property type="gene designation" value="CYM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06230W_A"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A301"/>
    <dbReference type="OMA" id="FPFQVHY"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000148">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000249943" description="Presequence protease, mitochondrial">
        <location>
            <begin position="27"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A8H8UNX0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q5JRX3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q9LJL3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1034" mass="117525" checksum="1FAF39E8F061F121" modified="2005-04-26" version="1" precursor="true">MLKTRLKQSRAISRVVRRYACSHPISPNLDKYPVGLKLHGYEVTQTSPIPEFSLTAVSLKHTESGATHLHLDSPNDSNNVFSIAFKTNPPDNTGVPHILEHTTLCGSKKFPVRDPFFKMTNRSLSNFMNAMTGHDYTFYPFATTNSKDFENLMDVYLSSVFEPQLNHTDFLQEGWRIENQNVHDISSKLEFKGVVYNEMKGQYSNSAYYFYIKFLESIYPSLNNSGGDPKKIVDLSYEGLLEFHSKNYHPSNAKTFTYGKLPLEDSLSKISKYYESFEKKVSSVDVKQPIFSTDKSEIFDVTIPGPVDTMNGKETSEQYCTSITWNLGNPLDPNMQYDIFKWKILSSLLFDGHNSPFYQELIESGYGDDFSANTGLDSTTALLSFTVGLNYLTKQKVDNFNEKVMEIINNKIIPELSNEESSSYHGRIDAILHQIEIGFKRHKPDFGFGLLSSIVPSWVNGVDPIDTLQVEKILSHFKEDYKQNGLRIFKELLEKTLCNPHSQKFKFTMEPREDFTKQLVKDENLMIEKRVSELTEDNKKAIYEQNLELAKLQLEDQNTEVLPTLTIDDIPKRGDFYAIDLGQVNKKVVHERVVDTNGLVYANALKDISYLPTKLYKYLPLFNNCLTNLAGTENTPITELETKIQMLTGGITFSSKISTDPYNIEQLKLQYVLSGMALKEKSSSVYDLWLEILTTTKFDTSDEVLEKLSVLIKNMGQNQINNIADRGHSYAAAVSSSKLTPSKYISDIVSGLSQVQFVMELNSKLESEGKEYLAKEIIPILQEIQKYVLQGEFRYRLVGNQEIIVENEKLIEKFDKDISSNRPTLSLTVTDGLSALLNSFNYNHTSENVLVNLPFQVGYSSLGKIGSSYSSKDGASLQILSQLYSFKNLHSKIRESNGAYGGGLTYDGLNGTLNFYSYRDPNPVKSIQTFRDSLSYGLDANWNDKDLQEAKLRVFQSVDAPINISSQGASAFFENIDDYLRQERRENFLGTTLKDLRDVTEKYLVDNQNNLVTVIGDNEILNVDNKWQIRNFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4Y0</accession>
    <name>Q5A4Y0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="16">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">DUS4</name>
        <name evidence="21" type="ordered locus">CAALFM_C500290WA</name>
        <name evidence="20" type="ordered locus">orf19.8581</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = uridine(20a) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53350"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = uridine(20a) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(20b) in tRNA + NAD(+) = uridine(20b) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53352"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(20b) in tRNA + NADP(+) = uridine(20b) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53356"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53358"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the Dus family. Dus4 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716804.1">
        <property type="nucleotide sequence ID" value="XM_711711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4Y0"/>
    <dbReference type="SMR" id="Q5A4Y0"/>
    <dbReference type="FunCoup" id="Q5A4Y0">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4Y0"/>
    <dbReference type="GeneID" id="3641580"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500290WA"/>
    <dbReference type="CGD" id="CAL0000191650">
        <property type="gene designation" value="DUS4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00290W_A"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_4_0_1"/>
    <dbReference type="InParanoid" id="Q5A4Y0"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102267">
        <property type="term" value="F:tRNA-dihydrouridine20b synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000159">
        <property type="entry name" value="tRNA-dihydrouridine synthase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16 18" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="29"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0000191650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AOW29475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="339" mass="38383" checksum="9F7DE3EC970AB4BD" modified="2005-04-26" version="1">MPSKQLRDPKYRPTEVIKQCQEKGRPAYIAGPMVRYSKLPFRELCRFYDVDIVYTPMILAREFVRNEVARSTDFTTNDSDKCVIVQVGVNNVDDFMKFIEMIHPFVDGIGINCGCPIKEQVREGIGAALMSDPDLVAELIKTAKDKYGDSICIDTKIRIHRDINQTIDFVNKVVEAGTDTLTVHGRTKNTRSSVPVNLDAIKIIRENVTTIPVIANGDCFTLTDFQKIVDYTGVDGVMSARGVLANPALFTGLDKTPWSAVEMFLHLVTAYGLPYKLAQYHLAKLMEDVIPRKYVKAINEKKNMVDIIDYLDEHFDLKRKGDKGFATRIEPPWKIELKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6R7</accession>
    <name>Q5A6R7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="5">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">SPT14</name>
        <name evidence="16" type="ordered locus">CAALFM_CR04040CA</name>
        <name evidence="15" type="ordered locus">orf19.8117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="5"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717350.1">
        <property type="nucleotide sequence ID" value="XM_712257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6R7"/>
    <dbReference type="SMR" id="Q5A6R7"/>
    <dbReference type="FunCoup" id="Q5A6R7">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6R7"/>
    <dbReference type="GeneID" id="3641019"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04040CA"/>
    <dbReference type="CGD" id="CAL0000182058">
        <property type="gene designation" value="SPT14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04040C_A"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_0_1"/>
    <dbReference type="InParanoid" id="Q5A6R7"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="14">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="190"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000182058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW31142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="452" mass="50973" checksum="420D6A8416740BCC" modified="2005-04-26" version="1">MGYNIAMVTDFFYPQPGGVEFHVYHLSQKLIELGHSVVIITHNYSSRNGVRVLTNGLKVYYVPLWVIYRSSVFPTVFSCFPILRNIFIRENIEIIHGHGSFSTLCHEAILHGRTMGLKTVFTDHSLFGFAEIGSIMGNKALKFTFSDVGHVICVSHTCKENTVLRGSIDPIKVSVIPNAVISKDFKPKSHCVNKNYTKEITIVVITRLFPNKGADLLTAVIPKICQLKPKVKFLIAGDGPKFLDLEQMREKYFLQERVTLVGAIKHEEVRDVMVQGDIYLHPSLTEAFGTVIVEAASCGLYVVTTKVGGIPEVLPNEMTSFAEPEENSLIDAAIDAINKIESNEIDTSKFHDAVAKMYSWNDIARRTENVYNSLDLDKLNESLLHRLQRYYCCGIIAGKLYALCVIVDIFIFVILEWLYPADHIDKATKWPSAIKEEDESEEETFIFPNKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7S6</accession>
    <name>Q5A7S6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C300680CA</name>
        <name evidence="2" type="ordered locus">orf19.12845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717765.1">
        <property type="nucleotide sequence ID" value="XM_712672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7S6"/>
    <dbReference type="STRING" id="237561.Q5A7S6"/>
    <dbReference type="PeptideAtlas" id="Q5A7S6"/>
    <dbReference type="GeneID" id="3640537"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300680CA"/>
    <dbReference type="CGD" id="CAL0000183629">
        <property type="gene designation" value="orf19.12845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00680C_A"/>
    <dbReference type="HOGENOM" id="CLU_1758554_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A7S6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000183629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="147" mass="15836" checksum="CC24D23A34B02EE3" modified="2005-04-26" version="1">MSNFNSSANDSTSTAPTASTTTNGDIGLNFASPKKITALEAYTPERGSKGNPSGTNNNNNTNNTNTNTTNNNNGKNTAGGPNTNQSSPAFWNFVQFSTPNGQSPVRKSSEEVGNNSPTLNRKIKRERENDETNSPFKKKQRTEMIDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8X7</accession>
    <accession>A0A1D8PCJ2</accession>
    <name>FYV4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein FYV4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FYV4</name>
        <name type="ordered locus">CAALFM_C101680CA</name>
        <name type="ORF">CaO19.10865</name>
        <name type="ORF">CaO19.3357</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS41 is involved in telomere length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit (mt-SSU).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718180.1">
        <property type="nucleotide sequence ID" value="XM_713087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8X7"/>
    <dbReference type="SMR" id="Q5A8X7"/>
    <dbReference type="FunCoup" id="Q5A8X7">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A8X7"/>
    <dbReference type="EnsemblFungi" id="C1_01680C_A-T">
        <property type="protein sequence ID" value="C1_01680C_A-T-p1"/>
        <property type="gene ID" value="C1_01680C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640198"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101680CA"/>
    <dbReference type="CGD" id="CAL0000197617">
        <property type="gene designation" value="orf19.10865"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01680C_A"/>
    <dbReference type="eggNOG" id="ENOG502SCMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126121_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A8X7"/>
    <dbReference type="OMA" id="FENKWEN"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="PRO" id="PR:Q5A8X7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000292469" description="Small ribosomal subunit protein mS41">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="170" mass="19825" checksum="EFBC226865B648B6" modified="2005-04-26" version="1" precursor="true">MFRTLLSSTVRSIQLKPVTSTLSTTIPSITSIPTVSYFSTSPINYKTNTSTRTKENVHDLTTFLTLIGRNSIEYKDLFEDDLNKFLSTTSAQMKNMGIDTRARRYLLRWRHKFLNDLEPLREHKLGKKRNGGERKAKTVIAKRQALERLEEKEKWAQEELEAEKRGERLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A948</accession>
    <name>Q5A948_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">MET2</name>
        <name evidence="7" type="ordered locus">CAALFM_CR02170WA</name>
        <name evidence="6" type="ordered locus">orf19.10149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718283.1">
        <property type="nucleotide sequence ID" value="XM_713190.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A948"/>
    <dbReference type="SMR" id="Q5A948"/>
    <dbReference type="FunCoup" id="Q5A948">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A948"/>
    <dbReference type="ESTHER" id="canal-q5a948">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="GeneID" id="3640070"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02170WA"/>
    <dbReference type="CGD" id="CAL0000174790">
        <property type="gene designation" value="MET2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02170W_A"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="InParanoid" id="Q5A948"/>
    <dbReference type="OMA" id="LGGCQGT"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000212">
        <property type="entry name" value="Acetyl-CoA--deacetylcephalosporin C acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000174790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW30967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="409" mass="45392" checksum="9C07EF59B6652F79" modified="2005-04-26" version="1">MTYKDVTEEQLQTNPYVKLVPGQTIVEIPEYTLECGETLHNFPVAYKTWGKLNETADNALVICHALSGSSDVDDWWGELLGTDRAFDPSRYLIICINFLGSPYGSCSPVTIDKSTGKPYGPSFPLVTFKDDVGIQRLILDSLNVKRLAAVVGGSMGGMLALEYSAIYNNTGYVQKVVALATAARTSAWCISWNETQRQCIFSDPFYDDGYYYETGNKPDSGLSAARMAALLTYRSRNSFESRFGRKLGPRSPNDGGASPRTKHEEHSLLHNDGSKLINGAPVNEKYPPTYFSAQSYMRYNGSKFINRFDANCYIAISRKLDTNDLSRGRVNAPNDANGDPLVHVLKDLSTPTLVIGIESDHLFTITEQKLLADNIPNAIFETLDSEEGHDAFLLEFEKINSFITSFLNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A9Z1</accession>
    <accession>A0A1D8PDL3</accession>
    <name>GATB_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="1">Glu-AdT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PET112</name>
        <name type="ordered locus">CAALFM_C105610WA</name>
        <name type="ORF">CaO19.10030</name>
        <name type="ORF">CaO19.2494</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718513.2">
        <property type="nucleotide sequence ID" value="XM_713420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A9Z1"/>
    <dbReference type="SMR" id="Q5A9Z1"/>
    <dbReference type="FunCoup" id="Q5A9Z1">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A9Z1"/>
    <dbReference type="EnsemblFungi" id="C1_05610W_A-T">
        <property type="protein sequence ID" value="C1_05610W_A-T-p1"/>
        <property type="gene ID" value="C1_05610W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639843"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105610WA"/>
    <dbReference type="CGD" id="CAL0000189636">
        <property type="gene designation" value="orf19.10030"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05610W_A"/>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_4_0_1"/>
    <dbReference type="InParanoid" id="Q5A9Z1"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="PRO" id="PR:Q5A9Z1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413250" description="Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <sequence length="488" mass="55741" checksum="A1A64194707D1DC0" modified="2017-04-12" version="2">MSQISMFVRKLHKFSYNPNYKFKCGLEIHTQLKTKYKLFSLSPTSYNEPPNTKLSYFDVGLPGTQPLLNPEALLLALKASVALNCDIQSYSSFDRKHYFYADQPLGYQITQHYYPLAKNGYVQLNKFDDMPDKVISLEQVQLEQDTGKTVNYDDRINVDLNRANTPLIEVVTKPDFENIDQVQAFVRKYQLLVSHLDICTGDLETGAIRVDANISVNNNPRVEIKNLGSSGEIVDALKYEYNRQVTLLQNNGKIIQETRGWNGIATESLRKKENAVDYRYVPDSELPVIRLDKNIQAQLQNTLDELPDSVLDRLTKEPYNLQLAHARNLLFQPEILDYYENIFGRIRDANKWFFHELLAAFAKSDVEFQVDIVLPDMLVDIVSSVEKNEISLTGARIILKHIIRNKSTKTLPQLIKELDIGKPEASAELEEAINEICQQIINTNADVVEKIARGHTNALQVLIGQAMKATKGKVHAKEFRSKFMELLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2025-06-18" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABD9</accession>
    <accession>A0A1D8PCA9</accession>
    <name>VPS27_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">VPS27</name>
        <name type="ordered locus">CAALFM_C100750CA</name>
        <name type="ORF">CaO19.13452</name>
        <name type="ORF">CaO19.6031</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text>Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Both IUM domains are necessary for efficient binding to ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718993.2">
        <property type="nucleotide sequence ID" value="XM_713900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABD9"/>
    <dbReference type="SMR" id="Q5ABD9"/>
    <dbReference type="FunCoup" id="Q5ABD9">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABD9"/>
    <dbReference type="EnsemblFungi" id="C1_00750C_A-T">
        <property type="protein sequence ID" value="C1_00750C_A-T-p1"/>
        <property type="gene ID" value="C1_00750C_A"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Vps27_GAT-like"/>
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        <property type="entry name" value="Znf_FYVE"/>
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        <property type="entry name" value="Znf_FYVE-rel"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="841"/>
        </location>
    </feature>
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            <begin position="30"/>
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    </feature>
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    </feature>
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            <end position="459"/>
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            <begin position="558"/>
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            <begin position="278"/>
            <end position="296"/>
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    </feature>
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            <end position="411"/>
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            <end position="427"/>
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        <ligand>
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    </feature>
    <evidence type="ECO:0000250" key="1"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00218"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="841" mass="94998" checksum="19D5607E1F31212C" modified="2017-04-12" version="2">MSWFGRATSDAPVATISQVELDNKIVEATSESIPNGEIDLSIAFEITDLIRSKKISNKIAMRSLKKRLTLIYLNPNLLLSSLKLIDLCIKNCGFGFLIEISSKEFMDYLIDFIFKIHYNTKELTYGHGGGDVGNKIKIGEMILKYLQNWKIIFENQQQLQYVEKKYQELKNQGFEFPDNNNNSGENDDFNDQVTQLNSKFVVDSEVPPDWVDNEECMICYSPFSMLNRKHHCRACGGVFCQTHSSNNIPLVNLGIMEPVRVCDNCFAKYDKSKKHSRNTSSSGDYNHQSRSIQNDYGGTHGSRRQGNNNDDDNDEEEQIRKAIELSLKESGAGGSGSGGPNSIPSQSRPSAQPPIDREPESETGNADDDEDAEMKAAIAASLKEYETEKSRQSQYQQIQPVQSTQSTQPESDLYNISFPTFSSTSNYPQPQFTASQPPPQQQQQQQAQQQAPSQDLSQAEEEQINLFITLMNSIKNDSRKQKDIMYDTNLNELYGKVIKLRPKLNKSLRNSIEKYETFLEMNNKISTITRLYDQFLEQKLNMAYGNHHISTQFTGVPQQQQEGQFTGSQQQQQQQQPHLPAQGTGYPRYGGSDTNVAQQQQQPPISPNEFYNNLPQHTGFQNYPSYPQNQGTAPDNSYLSQQPSGASTRQKQQQPPIQTYPNQLQPSEPDFEDDDNEEPVNTPQIRVAHNRTSSGSCPLYPTNDIIPDPYSANTNKSTTPNSDDHNYVAVSLPHYPPPEDLSNELPPQQHYVRRASSSLPPNAYEDASLKYPTLENVEHDYDKKKNQEQQQSVNESDFPDVSKVSQFNNRGEEDEGRRNSGASGASSNKKFVVEPEPLIEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD34</accession>
    <accession>A0A1D8PG87</accession>
    <name>PGA19_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Predicted GPI-anchored protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGA19</name>
        <name type="ordered locus">CAALFM_C200910WA</name>
        <name type="ORF">CaO19.2033</name>
        <name type="ORF">CaO19.9581</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="460" last="478">
            <title>Integrated proteomics and genomics strategies bring new insight into Candida albicans response upon macrophage interaction.</title>
            <authorList>
                <person name="Fernandez-Arenas E."/>
                <person name="Cabezon V."/>
                <person name="Bermejo C."/>
                <person name="Arroyo J."/>
                <person name="Nombela C."/>
                <person name="Diez-Orejas R."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="17164403"/>
            <dbReference type="DOI" id="10.1074/mcp.M600210-MCP200"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Antimicrob. Agents Chemother." volume="57" first="873" last="886">
            <title>Milbemycins: more than efflux inhibitors for fungal pathogens.</title>
            <authorList>
                <person name="Silva L.V."/>
                <person name="Sanguinetti M."/>
                <person name="Vandeputte P."/>
                <person name="Torelli R."/>
                <person name="Rochat B."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="23208712"/>
            <dbReference type="DOI" id="10.1128/AAC.02040-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text>Predicted GPI-anchored protein which may have a role during host infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4">Up-regulated upon interaction of cells with host macrophages and upon milbemycins A3 oxim derivative (A3Ox) treatment.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719482.2">
        <property type="nucleotide sequence ID" value="XM_714389.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD34"/>
    <dbReference type="SMR" id="Q5AD34"/>
    <dbReference type="STRING" id="237561.Q5AD34"/>
    <dbReference type="GlyCosmos" id="Q5AD34">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C2_00910W_A-T">
        <property type="protein sequence ID" value="C2_00910W_A-T-p1"/>
        <property type="gene ID" value="C2_00910W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638894"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200910WA"/>
    <dbReference type="CGD" id="CAL0000177109">
        <property type="gene designation" value="PGA19"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00910W_A"/>
    <dbReference type="HOGENOM" id="CLU_1219554_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AD34"/>
    <dbReference type="OrthoDB" id="4009871at2759"/>
    <dbReference type="PRO" id="PR:Q5AD34"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424923" description="Predicted GPI-anchored protein 19">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424924" description="Removed in mature form" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17164403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23208712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="229" mass="26090" checksum="668CA73A372B9F85" modified="2017-04-12" version="2" precursor="true">MFSTTSIVLWFTILLPVTLPVSIDNRDLLLKRHVEPNDIQFFNQGVRSSLSYIYQKRDVSDSDNEQVLRKSKKKKKTTSTGTPGNENTTDFASAQEFEKWEGDREGWQISAGLYFDKAIASDSCDSDSEDEDEGRKKFWIFTDDAPVDNENLIVSSEDKLELNYISSGKNLEGLTKVIRKAKGNSTTYNQSKIKFNVDAQGEDQFESGFGSLIPYNSFYLYILLFCIIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADL9</accession>
    <accession>A0A1D8PKM0</accession>
    <name>DCN1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Defective in cullin neddylation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DCN1</name>
        <name type="ordered locus">CAALFM_C306800CA</name>
        <name type="ORF">CaO19.14114</name>
        <name type="ORF">CaO19.6822</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330884.1">
        <property type="nucleotide sequence ID" value="XM_019475339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADL9"/>
    <dbReference type="SMR" id="Q5ADL9"/>
    <dbReference type="FunCoup" id="Q5ADL9">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADL9"/>
    <dbReference type="EnsemblFungi" id="C3_06800C_A-T">
        <property type="protein sequence ID" value="C3_06800C_A-T-p1"/>
        <property type="gene ID" value="C3_06800C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638497"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306800CA"/>
    <dbReference type="CGD" id="CAL0000200583">
        <property type="gene designation" value="orf19.14114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06800C_A"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047042_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADL9"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="PRO" id="PR:Q5ADL9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14351">
        <property type="entry name" value="UBA_Ubx1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000129510" description="Defective in cullin neddylation protein 1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="UBA-like">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00574"/>
        </source>
    </evidence>
    <sequence length="296" mass="34956" checksum="6A0D627A241FA445" modified="2017-05-10" version="2">MSSKTQLRQQFCELTGTSNTTATKYLESVRYDLARAIDNYYNKHPNKAQVTKKPVKVKIDDRLIQIFDKYKDSEDPNKIDIEGTLTYLGDLGISPDQIESLSLALLLKSPKTGVFTRENFLHIWQYYQCFDIGAMSEFITRFNKDLVNNIGGFKDISTVSDDENKSVPLKFQDLYNFTFKFSLETESQKFLDLDTAIEYWKLLLPIITETYSKDNKLDEEFKNHVNERVEQWFKFLTDTEYMTKKSISYDSWSMFYLFFKEIVLIDPIKFKDYDEMAAWPSVVDEFLEYLHDFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADP7</accession>
    <name>Q5ADP7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fesur1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">FESUR1</name>
        <name evidence="6" type="ordered locus">CAALFM_C307060WA</name>
        <name evidence="5" type="ordered locus">orf19.14086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719890.1">
        <property type="nucleotide sequence ID" value="XM_714797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADP7"/>
    <dbReference type="SMR" id="Q5ADP7"/>
    <dbReference type="STRING" id="237561.Q5ADP7"/>
    <dbReference type="GeneID" id="3638514"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307060WA"/>
    <dbReference type="CGD" id="CAL0000184766">
        <property type="gene designation" value="FESUR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07060W_A"/>
    <dbReference type="eggNOG" id="KOG1687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_1_3_1"/>
    <dbReference type="InParanoid" id="Q5ADP7"/>
    <dbReference type="OMA" id="GCGGIEM"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="98"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000184766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="223" mass="25112" checksum="12E95FF4B811B55D" modified="2005-04-26" version="1">MYSLSKRTLFQQLNKRISSTTTSSTIIPLSSLSSSSHISTRRYVSTKELTPQTLPTDFPLMSEKKATNAADYVLTSLDMIANWARKSSFWPVTFGLACCAVEMMHVSAPRYDQDRLGIIFRASPRQSDIMIVAGTLTNKMAPALRQVYDQMPDPKWVISMGSCANGGGYYHYSYSVVRGCDRVIPVDIYVPGCPPTAEALMYGVFQLQKKMMKTRITRLWYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEH4</accession>
    <name>Q5AEH4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C302900WA</name>
        <name evidence="5" type="ordered locus">CAALFM_C302990CA</name>
        <name evidence="2" type="ordered locus">orf19.7913</name>
        <name evidence="3" type="ordered locus">orf19.7927</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">SC5314</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Candida Genome Database"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">SC5314</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719979.2">
        <property type="nucleotide sequence ID" value="XM_714886.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719991.1">
        <property type="nucleotide sequence ID" value="XM_714898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEH4"/>
    <dbReference type="STRING" id="237561.Q5AEH4"/>
    <dbReference type="GeneID" id="3638337"/>
    <dbReference type="GeneID" id="3638388"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302900WA"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302990CA"/>
    <dbReference type="CGD" id="CAL0000192198">
        <property type="gene designation" value="orf19.7913"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000198826">
        <property type="gene designation" value="orf19.7927"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02900W_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02990C_A"/>
    <dbReference type="eggNOG" id="ENOG502RY54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053891_0_0_1"/>
    <dbReference type="OrthoDB" id="4073795at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000198826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="365" mass="43029" checksum="B7E1848F6E4AFA98" modified="2005-04-26" version="1">MKRQQEEPASQKEESVPQRKAVKYNQELTLLTLPTDILDLIFQDLSRQDAINLSTLDHEHRNVLKAIVFSRIRASWNDMRSEIDGRTGFLKQHRHLVTQLRIVDCDSYGEWNMDIFSDLLIDLPRLRHLLINSKFSSNWLKYRQDDNLQQLTLYFEPQDTRQVPGEIVSSSSTTTTTTINRIFSLEHIANFKMLTKLRLWHYHLYWEDMYPVLIVEDVELHNCTWEFPFTLSQFNYNSNIRRLVVSYAEGNAFAVSERYREFLQYGNGEDFSSLEELTVTVARGSLNSSVMSRFMNTGNFPRLRALRVLAREGAYNLSHWFGKLPTNSTLRVLDMQVDYEARDRERALKEANKYFPFLDVKIHRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AG71</accession>
    <accession>A0A1D8PNJ3</accession>
    <name>HSL1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase HSL1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSL1</name>
        <name type="ordered locus">CAALFM_C502840CA</name>
        <name type="ORF">CaO19.11784</name>
        <name type="ORF">CaO19.4308</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="J. Cell Biol." volume="164" first="581" last="591">
            <title>In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organization.</title>
            <authorList>
                <person name="Wightman R."/>
                <person name="Bates S."/>
                <person name="Amornrrattanapan P."/>
                <person name="Sudbery P."/>
            </authorList>
            <dbReference type="PubMed" id="14769857"/>
            <dbReference type="DOI" id="10.1083/jcb.200307176"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="55" first="381" last="395">
            <title>Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence.</title>
            <authorList>
                <person name="Umeyama T."/>
                <person name="Kaneko A."/>
                <person name="Nagai Y."/>
                <person name="Hanaoka N."/>
                <person name="Tanabe K."/>
                <person name="Takano Y."/>
                <person name="Niimi M."/>
                <person name="Uehara Y."/>
            </authorList>
            <dbReference type="PubMed" id="15659158"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04405.x"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Protein kinase involved in determination of morphology during the cell cycle of both yeast-form and hyphal cells via regulation of SWE1 and CDC28. Regulates pseudohypha formation, but is not required for septin ring organization or septum formation. Plays an essential role in virulence in a mouse model.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Bud neck</location>
        </subcellularLocation>
        <text>In the hyphal cells, localizes at a potent septation site before the completion of septum formation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylated throughout the cell cycle, except for the G1 phase.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Leads to elongated cell phenotype.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720615.2">
        <property type="nucleotide sequence ID" value="XM_715522.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AG71"/>
    <dbReference type="SMR" id="Q5AG71"/>
    <dbReference type="BioGRID" id="1220785">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AG71"/>
    <dbReference type="EnsemblFungi" id="C5_02840C_A-T">
        <property type="protein sequence ID" value="C5_02840C_A-T-p1"/>
        <property type="gene ID" value="C5_02840C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637810"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502840CA"/>
    <dbReference type="CGD" id="CAL0000190859">
        <property type="gene designation" value="HSL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02840C_A"/>
    <dbReference type="eggNOG" id="KOG0588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003363_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AG71"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="PRO" id="PR:Q5AG71"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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    <keyword id="KW-0067">ATP-binding</keyword>
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    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0843">Virulence</keyword>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGF0</accession>
    <name>Q5AGF0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C502220CA</name>
        <name evidence="7" type="ordered locus">orf19.11704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="AOW29649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715446.1"/>
    </dbReference>
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    <dbReference type="SMR" id="Q5AGF0"/>
    <dbReference type="FunCoup" id="Q5AGF0">
        <property type="interactions" value="246"/>
    </dbReference>
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    <dbReference type="GeneID" id="3637760"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502220CA"/>
    <dbReference type="CGD" id="CAL0000190615">
        <property type="gene designation" value="orf19.11704"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02220C_A"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_5_3_1"/>
    <dbReference type="InParanoid" id="Q5AGF0"/>
    <dbReference type="OMA" id="EDQWPEM"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
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        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:endopolyphosphatase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
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        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
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        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
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        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
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        <property type="term" value="P:inositol phosphate catabolic process"/>
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        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
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        <property type="term" value="P:polyphosphate catabolic process"/>
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        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DDP1p Polyphosphate phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
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        <property type="entry name" value="NUDIX_hydrolase_CS"/>
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    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
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        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
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    </dbReference>
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        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nudix"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51462"/>
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        <source>
            <dbReference type="CGD" id="CAL0000190615"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29649.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="192" mass="22012" checksum="6E2323CE70060818" modified="2005-04-26" version="1">MEQSQNYNNPNLPVKSQTAREGRENQRYNSETGARIVAGCMCLNETKDKIIMISSSKHKNRWIVPKGGNELDESELETAVRETWEEAGVEGIIIKKLPVVLDSRGSQAPVIKGEFDPDVATPKSEFHFFELQVDQLSTSWPEMKKRQRRWCTYSEAKHELLKSKRPELVDALNMSSILKDTIDDENPKQDNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGZ7</accession>
    <accession>Q3MPG3</accession>
    <name>RL5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL5</name>
        <name type="ordered locus">orf19.6541</name>
        <name type="ORF">CAALFM_C701790CA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_716286.1"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="m=1-298"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="m=1-298"/>
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    <dbReference type="PDB" id="7Q0F">
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        <property type="resolution" value="2.64 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="m=1-298"/>
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    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="m=1-298"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="AZ/m=1-298"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
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    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="AZ/m=1-298"/>
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    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
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        <property type="resolution" value="3.50 A"/>
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        <property type="resolution" value="2.45 A"/>
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    <dbReference type="PDB" id="9G1Z">
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        <property type="resolution" value="2.15 A"/>
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    <dbReference type="EMDB" id="EMD-50990"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="Q5AGZ7"/>
    <dbReference type="FunCoup" id="Q5AGZ7">
        <property type="interactions" value="1344"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AGZ7"/>
    <dbReference type="EnsemblFungi" id="C7_01790C_A-T">
        <property type="protein sequence ID" value="C7_01790C_A-T-p1"/>
        <property type="gene ID" value="C7_01790C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637057"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701790CA"/>
    <dbReference type="CGD" id="CAL0000178607">
        <property type="gene designation" value="RPL5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01790C_A"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AGZ7"/>
    <dbReference type="OMA" id="IYEAQVE"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
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        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14204">
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        <property type="entry name" value="Ribosomal_L5e"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
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    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456518" description="Large ribosomal subunit protein uL18">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30544.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="298" mass="34503" checksum="073D6EBD38C640AC" modified="2005-04-26" version="1">MPMQKEFRTSAYHSRFQTPFRRRQEGKTDYYQRKRLVTQHKAKYNSPKYRLVVRFTNKDIIAQIVSAHITGDVVFTAAYAHELPRYGIKYGLTNWSAAYAVGLLVARRALQKLGLDETYTGVEEVEGEFELTEAVEDGPRPFKVFLDIGLQRTTTGARVFGVLKGASDGGLYVPHSPNRFPGWDIEAEELDAELLRKYIFGGHVAEYMEELLDDDEEKYKSIFKNYIEEEIESEDVEEIYANAHEAIRADPSFKPTEKKFTKEQYKAESKKYRQQKLTRAERQAKVAKKIAEFKAQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJ65</accession>
    <name>Q5AJ65_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">PMC1</name>
        <name evidence="21" type="ordered locus">CAALFM_C301250WA</name>
        <name evidence="20" type="ordered locus">orf19.9295</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721798.1">
        <property type="nucleotide sequence ID" value="XM_716705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJ65"/>
    <dbReference type="SMR" id="Q5AJ65"/>
    <dbReference type="FunCoup" id="Q5AJ65">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJ65"/>
    <dbReference type="GeneID" id="3636627"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301250WA"/>
    <dbReference type="CGD" id="CAL0000196416">
        <property type="gene designation" value="PMC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01250W_A"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_2_1"/>
    <dbReference type="InParanoid" id="Q5AJ65"/>
    <dbReference type="OMA" id="YRMYVKG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PHI-base" id="PHI:8866"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000131">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1003"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1099"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1132"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="109"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1185"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0000196416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AOW28170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133710" checksum="BD01CAAE38173632" modified="2005-04-26" version="1">MAPRTPADKLGHASTLQLPTYDNDDQSSTNSTTPLHKDTPEETTDTSTTTNDVEPFHPPKLLSKTTTSPSIKLTSMLSKTSTKQNPNFPISLQSLSELHDPKSLKQLYDLGGIDNLLASLHTSFDGLNEHNETDLSQRKQYFGINRLPQKVQKSFLKLCWEALKDKVLVILCIAAIVSLALGCYESFGSGTHYDDEGLPLPKVDYVEGVAILVAVAIVVLVGAANDYQKERQFAKLNAKKEDREVIVVRNGGEQKLISIYDLMVGDVINLQTGDVVPADCILIQGEVECDESALTGESHTIHKVPVAKAMKVYQNHLPTNEDIGSTQIKFRDPYLISGAKVLSGLGNAVITAVGTNSIHGRTMMSLNHEPESTPMQVRLNDLAEGISKYGFLAAIVLFVVLFIRFCVEIAPNGNMNGAEPADKGKRFIDIIITAVTIVVVAIPEGLPLAVTLALAFATTRMAQNGNLVRVLKSCETMGGATAVCSDKTGTLTENKMRIVRGFFGLNKQGQPLEFNDTVGNQHDEPTSIDIINNEISSEQKVYLTTNIILNSTAFENSEYDEEKAKLARQKPPKQSFFSSLFKNSKKSQYQQMGLVDEPYLGNKTESALLTLAKDKFHLFDNKSLETCRQENNGDVIQVIPFESSRKWAGIVMKIPNGFRLYVKGAAEIIFKNCGFENNINDELIKLDRSKRDDVLSKIDEYANDALRAIALAHRDFVGISSWPPSELSSSSENKKTTTTAKEADPAKLINTSSSASEIHKMFILDALVGIQDPLKKGVAEAVLQCKRAGVTVRMVTGDNINTAKSISKECNILTSDDLSNEYSCMEGPQFRKLSIQKRREIVPQLKVLARSSPEDKRILVDTLRKAGEVVAVTGDGTNDAPALKLADVGFSMGIAGTEVAREASDIILMTDDFTDIVQAIKWGRTVSTSIKKFIQFQLTVNITACVLTFVSAVASSENKSVLTAVQLLWVNLIMDTLAALALATDKPDDSFLNRKPAGRTAPLISTSMWKMIIGQSMTQLIITFILHFAGKQLFFPGQSHINNHSEKQLAAMTFNTFVWLQFWKLFVTRKLDEADEITTIRGRISRENLDFFQHLFRNWYFITIALIIGGFQILIMFVGGAAFSIARQTPGMWATAILCGFLSIPVGLLIRIIPNIWIETIFPTKAFKKFLYIVGFGWLKFRKNKKTKDNEEDDEMDLEGGGNSDLKESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALK3</accession>
    <name>Q5ALK3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">PRS1</name>
        <name evidence="13" type="ordered locus">CAALFM_C202510WA</name>
        <name evidence="12" type="ordered locus">orf19.9148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722617.1">
        <property type="nucleotide sequence ID" value="XM_717524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALK3"/>
    <dbReference type="SMR" id="Q5ALK3"/>
    <dbReference type="FunCoup" id="Q5ALK3">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALK3"/>
    <dbReference type="GeneID" id="3635817"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202510WA"/>
    <dbReference type="CGD" id="CAL0000176742">
        <property type="gene designation" value="PRS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02510W_A"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="InParanoid" id="Q5ALK3"/>
    <dbReference type="OMA" id="YFGWARQ"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043101">
        <property type="term" value="P:purine-containing compound salvage"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF48">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000176742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW27290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="320" mass="35054" checksum="B26BB74103621D65" modified="2005-04-26" version="1">MSTNSIKLLASDVHRGLAELVSKRLGLRLTPSELKRESTGEVQFSIGESVRDEDIFIICQIGSGEVNDRVFELMIMINACKTASARRITVILPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKETIDYSEAIIISPDAGGAKRAAGLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICVIVDDMADTCGTLAKAAEVLLDNNAKDVIAIVTHGILSGNAIKNINNSKLKKVVCTNTVPFEDKLKLCPKLDTIDISAVIAESIRRLHNGESISYLFKNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALU8</accession>
    <name>Q5ALU8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">STT3</name>
        <name evidence="25" type="ordered locus">CAALFM_C201670CA</name>
        <name evidence="24" type="ordered locus">orf19.9053</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
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            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722527.1">
        <property type="nucleotide sequence ID" value="XM_717434.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ALU8"/>
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        <property type="interactions" value="1038"/>
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    <dbReference type="STRING" id="237561.Q5ALU8"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C201670CA"/>
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        <property type="gene designation" value="STT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01670C_A"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ALU8"/>
    <dbReference type="OMA" id="TWYAIGT"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:post-translational protein modification"/>
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        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
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    </dbReference>
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        <property type="entry name" value="Oligo_trans_STT3"/>
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        <property type="entry name" value="STT3-PglB_core"/>
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        <property type="entry name" value="STT3_N"/>
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    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="STT3"/>
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        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="542"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023211"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="CGD" id="CAL0000175183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AOW27213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="751" mass="85204" checksum="44975893D42B287A" modified="2005-04-26" version="1">MASTISSKPQLKVLGIDVESIRVLLKVIIFISIAGAAISSRLFSVIRFESIIHEFDPWFNFRATKYLVTHSFYEFLNWFDDRTWYPLGRVTGGTLYPGLMVTSGAIWHILRDWFALPVDIRNICVLLAPVFSGLTAICTYFLTKEMKDSSAGLLAAIFMGIAPGYISRSVAGSYDNEAIAITLLMATFYFWIKSMKMGSVFYATLTALFYFYMVSAWGGYVFITNLIPLHVFVLIFMGRYNAKLYTAYTTWYALGTLASMQIPFVGFLPIRSNDHMAALGVFGLLQLVAFGDYVKSKVPTKQFKSFLIVSIVLVVGLGIGGLFGLTAMGWIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPTAWPAFFFDTSMLIWLFPAGIYLCFQELKDEHVFIIIYSVLCSYFAGVMVRLMLTLTPVICVAAAIALSKLFDVYLDIVDLFTEKVGKYDDDVSDESKSSTKKSSSRFPIAGYLSKVLVLSTFTFYLFYFVLHCTWVTSNAYSSPSVVLASRNPDGSQHIIDDYREAYYWLRMNTPEDAKVMAWWDYGYQIGGMADRTTLVDNNTWNNTHIATVGKAMSSPEDVSYEILRQHDVDYVLVIFGGLLGYSGDDINKFLWMVRIAEGIWPDEIKERDYFTDRGEYKVDKDASSAMKNSLMYKLSYHRFTELFGGRDGVDRVRNQQIPANEVPKLNVVEEAFTSENWIVRIYKVKDLDNVGRDLHQATAFEESSSGTSKRNRSIKRPKLEVRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APC8</accession>
    <accession>A0A1D8PEN3</accession>
    <name>DAM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DAM1</name>
        <name type="ordered locus">CAALFM_C109730WA</name>
        <name type="ORF">CaO19.12300</name>
        <name type="ORF">CaO19.4837</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Curr. Biol." volume="21" first="889" last="896">
            <title>The requirement for the Dam1 complex is dependent upon the number of kinetochore proteins and microtubules.</title>
            <authorList>
                <person name="Burrack L.S."/>
                <person name="Applen S.E."/>
                <person name="Berman J."/>
            </authorList>
            <dbReference type="PubMed" id="21549601"/>
            <dbReference type="DOI" id="10.1016/j.cub.2011.04.002"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1295" last="1305">
            <title>The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere.</title>
            <authorList>
                <person name="Thakur J."/>
                <person name="Sanyal K."/>
            </authorList>
            <dbReference type="PubMed" id="21571923"/>
            <dbReference type="DOI" id="10.1128/EC.05093-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (PubMed:21549601). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (PubMed:21549601). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:21571923).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments. Within the complex, DAM1 and DUO1 may form the microtubule connections (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings (By similarity). Interacts with the outer kinetochore component NDC80; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6">Chromosome</location>
            <location evidence="5 6">Centromere</location>
            <location evidence="5 6">Kinetochore</location>
        </subcellularLocation>
        <text evidence="6">Localization to the kinetochore is independent of microtubules.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6">Kinetochore declustering (PubMed:21549601). Short mitotic spindle and an apparent absence of interpolar and cytoplasmic microtubules (PubMed:21571923). Cell cycle arrest in mitosis with unseparated DNA (PubMed:21571923). Inviable (PubMed:21549601, PubMed:21571923).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723523.1">
        <property type="nucleotide sequence ID" value="XM_718430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APC8"/>
    <dbReference type="SMR" id="Q5APC8"/>
    <dbReference type="BioGRID" id="1217914">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5APC8">
        <property type="interactions" value="177"/>
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    <dbReference type="STRING" id="237561.Q5APC8"/>
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        <property type="gene ID" value="C1_09730W_A"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
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        <property type="term" value="C:mitotic spindle polar microtubule"/>
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        <property type="term" value="C:mitotic spindle pole body"/>
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    </dbReference>
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        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="UniProtKB"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:mitotic sister chromatid biorientation"/>
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        <property type="project" value="UniProtKB"/>
    </dbReference>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:protein transport along microtubule to mitotic spindle pole body"/>
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        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000127657" description="DASH complex subunit DAM1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9HDZ6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21549601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21571923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="21549601"/>
        </source>
    </evidence>
    <sequence length="277" mass="31906" checksum="049FEDAD241ED124" modified="2005-04-26" version="1">MSSSKPVTPRNDRRQNSGRRHSHRSSGIQLPSMSPKVHHYPIDAENLPMDSPEIVEKFASLAESMETLDLHMHDLCHIHDHISNQFNESFASFLYGLSMTMWCVDFPGCPSREQWEALISKRERKERIEVLKKRLADAQKLNDRLKLRLSDEAKQKPQQLTSQQRPTHGPTRQIKQQPRSVNFNTHSSDSISTNSYTSGDFNTNRRVSRIPQPSRSNLPSSRFQAPSKSGPNLNQPPRYMRGLFDGNNTLNTSNYSRIKKPIHNRSVNNLQNRPPFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q9B8C8</accession>
    <name>NU4M_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>NADH-ubiquinone oxidoreductase chain 4</fullName>
            <ecNumber>7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>NADH dehydrogenase subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NAD4</name>
        <name evidence="4" type="ordered locus">CM_00440W</name>
        <name type="ORF">CaalfMp14</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="865" last="872">
            <title>Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.</title>
            <authorList>
                <person name="Anderson J.B."/>
                <person name="Wickens C."/>
                <person name="Khan M."/>
                <person name="Cowen L.E."/>
                <person name="Federspiel N."/>
                <person name="Jones T."/>
                <person name="Kohn L.M."/>
            </authorList>
            <dbReference type="PubMed" id="11208783"/>
            <dbReference type="DOI" id="10.1128/JB.183.3.865-872.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2"/>
    <dbReference type="EMBL" id="AF285261">
        <property type="protein sequence ID" value="AAG59598.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_075041.2">
        <property type="nucleotide sequence ID" value="NC_002653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9B8C8"/>
    <dbReference type="SMR" id="Q9B8C8"/>
    <dbReference type="STRING" id="237561.Q9B8C8"/>
    <dbReference type="EnsemblFungi" id="CM_00440W-T">
        <property type="protein sequence ID" value="CM_00440W-T-p1"/>
        <property type="gene ID" value="CM_00440W"/>
    </dbReference>
    <dbReference type="GeneID" id="802562"/>
    <dbReference type="KEGG" id="cal:CaalfMp14"/>
    <dbReference type="CGD" id="CAL0000192075">
        <property type="gene designation" value="NAD4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CM_00440W"/>
    <dbReference type="InParanoid" id="Q9B8C8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000356878" description="NADH-ubiquinone oxidoreductase chain 4">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000192075"/>
        </source>
    </evidence>
    <sequence length="464" mass="51142" checksum="11036F46FBD72C08" modified="2003-10-01" version="2">MTLIYILILAGVSIFSRLLPTYGKGLILVASILVVLPTMTDWEEVGIYYTSDGIADIFILLTAYLLPLSIIANWNNIRSLLYFELILNLGVILLINFMCQDMLSFYVYFEISLAPLFILIGLYGANNRDKAADYILIYTLFSSLFMLLAIGTYEVLIGNTDYQAVSLVVLSTDLQCILFLCISAGIMVKTPLVPVHTWLPVVHSESPLAGSMLLAGVILKLAVYAIIRLIIPTLSDATVLYTPVVYVICAITIIYTSIITLRQTDLKVIVAYSSISHMAVCILGILSNSLAGINGSLILSLAHGFVSPALFIIVGGILYDRYHHRLIYYYQGLLTYMPILAIYLLILSFSNIGTPLTVNFIGELLSLTGAIGRSTILGCISAFSVLLSAAYMLKVTNRLTGGIRTPYTALTSDCTYRESLLMIALIIPTLWYGLYPNGIINMIWQGSKLLYIFVITQYNVIGNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q9UW24</accession>
    <accession>A0A1D8PNA2</accession>
    <accession>Q59YI1</accession>
    <name>PIK1A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Phosphatidylinositol 4-kinase PIK1a</fullName>
            <shortName>PI4-kinase</shortName>
            <shortName>PtdIns-4-kinase</shortName>
            <ecNumber>2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PIKA</name>
        <name type="ordered locus">CAALFM_C501760CA</name>
        <name type="ORF">CaO19.3199</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Science" volume="285" first="1271" last="1275">
            <title>Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Hull C.M."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="10455055"/>
            <dbReference type="DOI" id="10.1126/science.285.5431.1271"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67"/>
    <dbReference type="EMBL" id="AF167162">
        <property type="protein sequence ID" value="AAD51405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714615.1">
        <property type="nucleotide sequence ID" value="XM_709522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9UW24"/>
    <dbReference type="FunCoup" id="Q9UW24">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9UW24"/>
    <dbReference type="EnsemblFungi" id="C5_01760C_A-T">
        <property type="protein sequence ID" value="C5_01760C_A-T-p1"/>
        <property type="gene ID" value="C5_01760C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643765"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501760CA"/>
    <dbReference type="CGD" id="CAL0000190377">
        <property type="gene designation" value="PIKA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01760C_A"/>
    <dbReference type="HOGENOM" id="CLU_002446_2_0_1"/>
    <dbReference type="InParanoid" id="Q9UW24"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:trans-Golgi network"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to nitrogen starvation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
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    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042998">
        <property type="term" value="P:positive regulation of Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000021">
        <property type="entry name" value="Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000088833" description="Phosphatidylinositol 4-kinase PIK1a">
        <location>
            <begin position="1"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="658"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="664"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic loop" evidence="2">
        <location>
            <begin position="805"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Activation loop" evidence="2">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="956" mass="109252" checksum="940777ECF976C68B" modified="2000-05-01" version="1">MPVAPHELRDTIKSRDLGLFQCIDLLKQHNDNIGVHHQLVQKLYSYSYDELEFFIPQFIQLLVNFETDSMALEDFLLHYCNQFPHFSLIVFWYLQAFLFELRNEPKSYSFQTVRKFINKLQNILFNVETSFHIRGPEFRENMQPALILCGSVASAFSSPLVNEYALPIVRSQGKQQKSFVFKLASFQKSLTRNLTMKNQRLSADAITPVISDDDSKVSNRIQESQRLKTKYSKKKISAALQLDDSENYTTDEEELGYVQTLSRPKIREMKYTEVEENLKINTIIRSKKNRSKTTVNSISFFSDTDQSASMEEYNRSAQSLPELVRTRSRLDLYSSESEAALGTSRNSAELIISKKKFMGSEVKTRPYKELLKILQVNYSKKETSFIMSLQNISLRLSSVPKVARLSALRAELSIINESILPSEIDIPQLLPVTSNKNKKFHKILKLNINEACVLNSAERVPYLLLIEYLSDEIDFNPFSDQNQKIINDCVRKPEVKPNDQISGDDDTSVVSSIQEEMFLDNNASENYNEDGDLGEISLLHSRSSSRDWAKSTPGSPVARSSQEDEKFYGNVSSTTGGTIESSVLADQMRIASLMLQQLESSGQSNTQQFVSIRNRIIESMISLQDQFDFIDYETLKELKTDEQDAGKRKLENDFKLAEDWNEKKHRIRKSSIYGHLENWDLCSVIVKNGDDLPQEAFACQLISLISNIWKKHKVDFWTKRMKILITSANAGLVETITNAMSIHSIKKSLTELSIENGENAKGRIFTLKDYFQKLYGSVDSSKYVKAQENFAISLASYSIICYVLQIKDRHNGNIMLDHEGHIIHIDFGFLLSNSPGSVGFEAAPFKLTSEYVEVLGGLESKAYLKFVDTCKNCFKALRKEWGQIVSIVELMQKGSSLPCFNNGDNTSVLLQQRLQLHLSDEEIDSFIEVYLIEKSVGSMYTRLYDQFQMITQGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PC71</accession>
    <name>A0A1D8PC71_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCR4-NOT core subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C100330CA</name>
        <name evidence="5" type="ordered locus">orf19.13496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719037.2">
        <property type="nucleotide sequence ID" value="XM_713944.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PC71"/>
    <dbReference type="SMR" id="A0A1D8PC71"/>
    <dbReference type="FunCoup" id="A0A1D8PC71">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PC71"/>
    <dbReference type="GeneID" id="3639296"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100330CA"/>
    <dbReference type="CGD" id="CAL0000200147">
        <property type="gene designation" value="orf19.13496"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00330C_A"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PC71"/>
    <dbReference type="OMA" id="IFYMKPR"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="182" mass="20882" checksum="6DB60C336AC05F92" modified="2017-01-18" version="1">MVSSTLPPEEGLGKYGMQGLTSLVKMEQSDITNFALGQDISKCGLDLTKDSEILKNLSSPWAETSRSEVEPYYNLPKSIRASSINPPPGPCDSKIQNFTDETLFYIFYMKPRDTLQEYAARELVARNWRYHKGIQVWLTKDSNVEPVLINPDVEKGVYIFFDPHNWEKIRKEFVLHYSLVQA</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCL1</accession>
    <name>HGT1_CANAL</name>
    <protein>
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            <taxon>Pichiomycetes</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="FEMS Microbiol. Lett." volume="182" first="15" last="21">
            <title>Molecular cloning and functional characterisation of a glucose transporter, CaHGT1, of Candida albicans.</title>
            <authorList>
                <person name="Varma A."/>
                <person name="Singh B.B."/>
                <person name="Karnani N."/>
                <person name="Lichtenberg-Frate H."/>
                <person name="Hofer M."/>
                <person name="Magee B.B."/>
                <person name="Prasad R."/>
            </authorList>
            <dbReference type="PubMed" id="10612724"/>
            <dbReference type="DOI" id="10.1111/j.1574-6968.2000.tb08866.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="J. Mol. Evol." volume="55" first="336" last="346">
            <title>Identification and phylogenetic analysis of a glucose transporter gene family from the human pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Fan J."/>
                <person name="Chaturvedi V."/>
                <person name="Shen S.H."/>
            </authorList>
            <dbReference type="PubMed" id="12187386"/>
            <dbReference type="DOI" id="10.1007/s00239-002-2330-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="J. Infect. Dis." volume="204" first="802" last="809">
            <title>Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule.</title>
            <authorList>
                <person name="Lesiak-Markowicz I."/>
                <person name="Vogl G."/>
                <person name="Schwarzmueller T."/>
                <person name="Speth C."/>
                <person name="Lass-Floerl C."/>
                <person name="Dierich M.P."/>
                <person name="Kuchler K."/>
                <person name="Wuerzner R."/>
            </authorList>
            <dbReference type="PubMed" id="21844307"/>
            <dbReference type="DOI" id="10.1093/infdis/jir455"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH HOST COMPLEMENT FACTORS FH AND C4BP AND HIV GP160</scope>
    </reference>
    <comment type="function">
        <text evidence="4 6 9">High-affinity glucose transporter (PubMed:10612724, PubMed:12187386). Acts as a multifunctional complement-evasion molecule that causes down-regulation of complement activation by acquisition of human complement factors FH and C4BP (PubMed:21844307). Also functions as a human immunodeficiency virus (HIV) receptor via binding the viral gp160 protein (PubMed:21844307). Modulates hyphae formation (PubMed:21844307).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the human complement factors FH and C4BP (PubMed:21844307). Also binds human immunodeficiency virus (HIV) protein gp160 (PubMed:21844307).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Expressed in presence of 2 percent glucose (PubMed:12187386). Expression is induced by progesterone and drugs such as cycloheximide, benomyl and chloramphenicol (PubMed:10612724).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Reduces the binding of human FH and C4Bp as well as of human immunodeficiency virus (HIV) gp160 protein onto C.albicans cell surface (PubMed:21844307). Reduces ability to form hyphae (PubMed:21844307).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712952.2">
        <property type="nucleotide sequence ID" value="XM_707859.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCL1"/>
    <dbReference type="SMR" id="A0A1D8PCL1"/>
    <dbReference type="STRING" id="237561.A0A1D8PCL1"/>
    <dbReference type="GlyCosmos" id="A0A1D8PCL1">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_01980W_A-T">
        <property type="protein sequence ID" value="C1_01980W_A-T-p1"/>
        <property type="gene ID" value="C1_01980W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645420"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101980WA"/>
    <dbReference type="CGD" id="CAL0000200616">
        <property type="gene designation" value="HGT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01980W_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCL1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904659">
        <property type="term" value="P:D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036168">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045916">
        <property type="term" value="P:negative regulation of complement activation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052067">
        <property type="term" value="P:symbiont-mediated perturbation of host phagocytosis"/>
        <property type="evidence" value="ECO:0000269"/>
        <property type="project" value="SigSci"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000443417" description="High-affinity glucose transporter 1">
        <location>
            <begin position="1"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="10612724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12187386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21844307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="10612724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="12187386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="545" mass="60670" checksum="A9A0FD77DC70780E" modified="2017-01-18" version="1">MSSKIERIFSGPALKINTYLDKLPKIYNVFFIASISTIAGMMFGFDISSMSAFIGAEHYMRYFNSPGSDIQGFITSSMALGSFFGSIASSFVSEPFGRRLSLLTCAFFWMVGAAIQSSVQNRAQLIIGRIISGIGVGFGSAVAPVYGAELAPRKIRGLIGGMFQFFVTLGIMIMFYLSFGLGHINGVASFRIAWGLQIVPGLCLFLGCFFIPESPRWLAKQGQWEAAEEIVAKIQAHGDRENPDVLIEISEIKDQLLLEESSKQIGYATLFTKKYIQRTFTAIFAQIWQQLTGMNVMMYYIVYIFQMAGYSGNSNLVASSIQYVINTCVTVPALYFIDKVGRRPLLIGGATMMMAFQFGLAGILGQYSIPWPDSGNDSVNIRIPEDNKSASKGAIACCYLFVASFAFTWGVGIWVYCAEIWGDNRVAQRGNAISTSANWILNFAIAMYTPTGFKNISWKTYIIYGVFCFAMATHVYFGFPETKGKRLEEIGQMWEERVPAWRSRSWQPTVPIASDAELARKMEVEHEEDKLMNEDSNSESRENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCM9</accession>
    <name>A0A1D8PCM9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor MBP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">SWI4</name>
        <name evidence="10" type="ordered locus">CAALFM_C101790WA</name>
        <name evidence="9" type="ordered locus">orf19.12020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25866.1"/>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDP2</accession>
    <name>A0A1D8PDP2_CANAL</name>
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        <submittedName>
            <fullName evidence="8">Prn3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">PRN3</name>
        <name evidence="8" type="ordered locus">CAALFM_C105870WA</name>
        <name evidence="7" type="ordered locus">orf19.9999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713391.2"/>
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    <dbReference type="CGD" id="CAL0000180196">
        <property type="gene designation" value="PRN3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05870W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="GRMRHRD"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pirin"/>
    </dbReference>
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        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="6">
        <location>
            <begin position="173"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000180196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="326" mass="35952" checksum="03FA9A0CB6AAF750" modified="2017-01-18" version="1">MSVRSIAKVVTPNPPRPGSPVKIRNSIGSSNQFNPFLLFDHFTIPSTGGFPAHPHRGQETITLVLKGGVAHEDFTGSKGVLYPGDLQFMTAGKGVVHSEMPVPNEDGSPSVGLQLWVDLPNDMKDVKPRYRDLREWEIPQVVADDGKVIVKVISGKSHGVESQKELAYTPINYYHYKVKAGGKFKQELSPGFNYFLYVLNGKNLKLNGNTTVDKYQTAFFNETGDYITGENTATEETEANESEFVLIGGKILNQKPVQYGPFVASSKTGITKALLDYELARNGFEHRVKWNSLISRGVNKSMVTGPLNGCPKKRAADKKSYLDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PDQ8_CANAL</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C105970WA</name>
        <name evidence="3" type="ordered locus">orf19.9985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718472.1">
        <property type="nucleotide sequence ID" value="XM_713379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDQ8"/>
    <dbReference type="STRING" id="237561.A0A1D8PDQ8"/>
    <dbReference type="GeneID" id="3639874"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105970WA"/>
    <dbReference type="CGD" id="CAL0000196946">
        <property type="gene designation" value="orf19.9985"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05970W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PDQ8"/>
    <dbReference type="OrthoDB" id="4027675at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="417"/>
        </location>
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            <end position="590"/>
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            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
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            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
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            <end position="552"/>
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            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000196946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="590" mass="61390" checksum="6DB9A9F04304DB31" modified="2017-01-18" version="1">MQVTTFLVIAASLVTLVTSSPLTFVSSTYNSLPTPTTTISAHAGCDVVFTSEGYTTTVPFEDCPLTSVSAPPGFPPRPYGGCTTYNGEAYCAQGNCDMFYVSYYHTFFWVTSCSTGGCSFITDGPSIGFDCATTRTLDDGCLEIQSKEWDAIHITTTCPNNTTPTETCGPTSFAYEETIYDFTTCPSNAPLPSGCSLDETIVGTRTLDVLKCSTTNPPPPTDPPIICQLETLVSDDITLTSMSCNYIPDDCSTSTSLNVHNRTVTYFVCPTTTIEPLPPGVTTTTICPHSKCHSPPGGGNNGGGNNGGGNNGGGHGGGHGGGHGGGHGGGHGGDNGSGDNGGDHSGGDNGGGDHSGGDNGGGNNGGDNNGGNCPPQSTITVTVAQETKTETQTITEYKTKIVEKPSKPTKPPHGHQDHTVTETCYIYESIITYPYTTITSSYTFTVKPTNTETSITTDSSETPDTSDSIEPSETTESIESVEPTDPTDPTDSTGSTEPTESPEPTDSTEPTESTKPTDTTDSTGSTEPTETTETLDPTEPTESTEPVESTEPIVSIDPTDPTEPTDPTETPDPTQPTVTILPAKSTTLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDR2</accession>
    <name>A0A1D8PDR2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">HAC1</name>
        <name evidence="11" type="ordered locus">CAALFM_C106130CA</name>
        <name evidence="10" type="ordered locus">orf19.9968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330657.1">
        <property type="nucleotide sequence ID" value="XM_019475112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDR2"/>
    <dbReference type="SMR" id="A0A1D8PDR2"/>
    <dbReference type="STRING" id="237561.A0A1D8PDR2"/>
    <dbReference type="GeneID" id="3639849"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106130CA"/>
    <dbReference type="CGD" id="CAL0000199458">
        <property type="gene designation" value="HAC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06130C_A"/>
    <dbReference type="eggNOG" id="ENOG502S526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDR2"/>
    <dbReference type="OMA" id="DAFWNYP"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010570">
        <property type="term" value="P:regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14710">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000101">
        <property type="entry name" value="BZIP transcription factor HacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000199458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="367" mass="41528" checksum="2DF063C9C53EA219" modified="2017-01-18" version="1">MELTVDNTNTTSNIDDLSVATPTSLMTSTTTSPSMSTSTSSHSNTLDIDPATFKSTLPPRKRAKTQEEKEQRKIERILRNRRAAHASREKKRKHVEYLENYVLKLETNLMKLNNNYNQAFELLTKDNQELLLSKLEVLDDVSDLKEQIHSNMSGTRRSHNKKSNDEDIEEEDEDEHQEEGHVEKQEIKKEEPVSKKRKLNTKTKSKTKTKSSNKTMTSTPPSSVSSLSPDVTNFSGTNTTMSSPIQIKKEFNIDNIFIKKEFSQSPLQPTHQPEQQEQQHEIYLKSESKDAFWNYPSPLSFHDSPLQIDIDTSSSSSTSPSSSSSLISSSGPTNHSIADLAEPIESFQLDFDDFFSILGDDVEVHKV</sequence>
</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="CGD" id="CAL0000198419"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="437" mass="49891" checksum="5B88D90ACAF78183" modified="2017-01-18" version="1">MSKQTTHIHKLIADYLKENNYLETLKQFENEHGNPIPATKLLDESLSDIINDRIQYNTLLDDNKTNEGVINVNDELAPELKVIITQQFSNWITPFPHQPSKLIDIDGLVISSCHDKKNELIYLSSNDCKVYVIKQKQIIHTLKMPVVIKKILTIGNSDKMVLVGMNGILYLRERGTLEEIDQFQAHKRLIVDAKSITFQNRNYLITLGWDFHLRLILLNENNTDQNEVQRFEILSELKLKQQGSCLDVTVYQDQLVIILGKTENTLLDVITMSGKDSRELTLVHKISLNDAEFTAAGFSPRCLMIENSGHVPLIAVGTSHEPYMRLIIVPLQDLANEPSIKRNQIIKNLNTMSPQDRYSQPIIAWRLQKSDNNKASGVWVMGDDGTIRGIDIVEDQVIVELKDGHQGKIKDFITFIDEDSVEKLITSGIDREIVTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDY0</accession>
    <name>A0A1D8PDY0_CANAL</name>
    <protein>
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            <fullName evidence="8">Uncharacterized protein</fullName>
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        <name evidence="7" type="ordered locus">orf19.6225.1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06840C_A"/>
    <dbReference type="eggNOG" id="ENOG502S49F">
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    </dbReference>
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    <dbReference type="OrthoDB" id="76305at2759"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000194611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="97" mass="10827" checksum="5EC9836E3B9EAA77" modified="2017-01-18" version="1">MSTASKITLGASCAFAVGAFVFINYSQQAERQALRQGPIKDAARQQAKQLEKSKKQLANELEHKEQTELREKYLKLQPLSDEIIKGEEGKIIPPKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEM4</accession>
    <name>A0A1D8PEM4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
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    <gene>
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        <name evidence="21" type="ordered locus">CAALFM_C109160WA</name>
        <name evidence="20" type="ordered locus">orf19.4774</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
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    <sequence length="379" mass="43876" checksum="F0737992FE9C2A38" modified="2017-01-18" version="1">MIGLSTYRNLPTLLTTTTVISTALRSKQLLRFTTTTSTKSGSSTSTTSTIVGNSNPKSPIDEDNLEKPGTIPTKHKPFNIQTEVYNKAGIEANDDDKFLTKPTYRHEDFTEAGVYRVHVTHRPPRTIGDKISCYGTLFFRKCFDLVTGYAVPDPDKPDQYKGTRWEMTEGKWMTRCIFLESIAGVPGSVAGFIRHLHSLRMLTRDKAWIETLHDEAYNERMHLLTFIKIGKPSWFTRSIIYIGQGVFTNIFFLVYLMNPRYCHRFVGYLEEEAVRTYTHLIDELDDPNKLPDFQKLPIPNIAVQYWPELTPESSFKDLILRIRADEAKHREINHTFANLEQWQDRNPFALKIKDSDKPQPNYNLDVTRPQGWERKDLYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PES5</accession>
    <name>HNV1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxyurea-responsive negative regulator of virulence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HNV1</name>
        <name type="ordered locus">CAALFM_C110050WA</name>
        <name type="ordered locus">orf19.12336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2025" name="Cell. Signal." volume="134" first="111931" last="111931">
            <title>Genome-wide transcriptional profiling identifies HNV1 as a hydroxyurea-responsive negative regulator of virulence in Candida albicans.</title>
            <authorList>
                <person name="Yang S."/>
                <person name="Feng Y."/>
                <person name="Gao W."/>
                <person name="Wang J."/>
                <person name="Liu Y."/>
                <person name="Feng J."/>
            </authorList>
            <dbReference type="PubMed" id="40484102"/>
            <dbReference type="DOI" id="10.1016/j.cellsig.2025.111931"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as a critical hub linking DNA replication stress to redox homeostasis and virulence (PubMed:40484102). Functions as a negative regulator of virulence by suppressing extracellular protease secretion through up-regulation of SAP4, SAP5 and SAP6, while also modulating antioxidant defense pathways including CAT1, FDH1 or HPD1 (PubMed:40484102).</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Exhibits robust induction by hydroxyurea (HU), methyl methanesulfonate (MMS), and H(2)O(2).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Confers enhanced resistance to oxidative stress and hypervirulence in both Galleria mellonella and murine systemic infection models.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718463.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PES5"/>
    <dbReference type="EnsemblFungi" id="C1_10050W_A-T">
        <property type="protein sequence ID" value="C1_10050W_A-T-p1"/>
        <property type="gene ID" value="C1_10050W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634811"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110050WA"/>
    <dbReference type="CGD" id="CAL0000187748">
        <property type="gene designation" value="HNV1"/>
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    <dbReference type="eggNOG" id="ENOG502RQBI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111136" description="Hydroxyurea-responsive negative regulator of virulence">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="40484102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="40484102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="283" mass="32766" checksum="34E2FD150FF1A355" modified="2017-01-18" version="1" precursor="true">MKIRKTSEFIHLITMILSIFISISSCSSSSHSNSHSHSTSMSISSSASTLPIIHIKDNIDELTYFDLTSITTNTVYKINNDQALVYENNQWIHVQTTSTPIIHSKFIPISHCLNQKWGDGGAIDFQTTTIYTMINTFDLALTLSIIFYYEKLTHSWEFSKVLTLRDIYYCSVAPGEIGQIWIDLQYHEFKSIKYRILENFPKFTIHNREESNNNKVISSKNRKKKFLSKKKLKFGKWKEISKMFLLNGKKSPIISCITTNDNKDKQLDCEGKSLLKLKEFKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PES9</accession>
    <name>A0A1D8PES9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C110230CA</name>
        <name evidence="7" type="ordered locus">orf19.12358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718482.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PES9"/>
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    <dbReference type="CGD" id="CAL0000181206">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
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        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
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    </dbReference>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEY1</accession>
    <name>A0A1D8PEY1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">SFT2</name>
        <name evidence="10" type="ordered locus">CAALFM_C110770WA</name>
        <name evidence="9" type="ordered locus">orf19.9878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713947.2">
        <property type="nucleotide sequence ID" value="XM_708854.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEY1"/>
    <dbReference type="FunCoup" id="A0A1D8PEY1">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEY1"/>
    <dbReference type="GeneID" id="3644442"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110770WA"/>
    <dbReference type="CGD" id="CAL0000197615">
        <property type="gene designation" value="SFT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10770W_A"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEY1"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000197615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="217" mass="24417" checksum="D22C0D169D562E5E" modified="2017-01-18" version="1">MSTESENVFRQSFRNWNDRSNRTTTSSTSNRPVLSEWTDYFKTGANDLYNRLPSSVQDIGATNNNVQEPSWYNLSRLERLIGFGCCLGASVLCFVLCFFMLPVLALRPRKFGLLWTGGSVLFVVSFGVLQGPYNYVRHLLSRDRILFTGVFFSSVFLTIYSACILKSSILTIFTSIIEILAVLYYTLSYFPFGATTLTFFTSYVVGYVGGLIGGVIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF45</accession>
    <name>RL37B_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein eL37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L37-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPL37B</name>
        <name type="ordered locus">orf19.667.1</name>
        <name type="ORF">CAALFM_C111360WA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
        <scope>COFACTOR</scope>
    </reference>
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        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
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        <cofactor evidence="2">
            <name>Zn(2+)</name>
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    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L37e"/>
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    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000456641" description="Large ribosomal subunit protein eL37">
        <location>
            <begin position="1"/>
            <end position="90"/>
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    <feature type="zinc finger region" description="A20-type" evidence="1">
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            <begin position="13"/>
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    <feature type="binding site" evidence="1 2 8">
        <location>
            <position position="19"/>
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        <ligand>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFF4</accession>
    <name>A0A1D8PFF4_CANAL</name>
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        <submittedName>
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        <name evidence="8" type="ordered locus">CAALFM_C112260WA</name>
        <name evidence="7" type="ordered locus">orf19.12701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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    </evidence>
    <sequence length="375" mass="43444" checksum="DF0BD05DAEFE04CF" modified="2017-01-18" version="1">MDKSTFKQLTNEYDILYLIYHRSKNQHRQQIWFKYLNMMIRNLRKILKLQIDINRIRTTTTTTTTTTTTTTTTTTTKDKIDYKTNQIIQYSNKILKLMKSSYWNYNSILVLGQYITLGLGLIGSLSKITHLIINGINGVQKRGINRDSFINKMNNDRQRVDGVDVVGSKDLKSNNEDEIDFGEVIPYEEEVEKVSINDEVKNNCKINKSNTLQFQGKENLQRFDKIDDDTDIQQIKNDDDKSHSKKSKRNSLSLSEEEEEEEEDSNIIFKKSKSKSKSTTIHNQSNIHSEQISINDENNNKSTSTSTSTDTKKRKLIDTDTIDDIFESSKTKTKTKTKTKTKTFDNKKLKKKDTTTKPLKKIKKKKKSAIDDIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG96</accession>
    <name>A0A1D8PG96_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="5">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">KAR2</name>
        <name evidence="23" type="ordered locus">CAALFM_C201120WA</name>
        <name evidence="22" type="ordered locus">orf19.9564</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Heat shock protein that may play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Binds human histatin-5, an antifungal peptide from saliva.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="5"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719462.2">
        <property type="nucleotide sequence ID" value="XM_714369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG96"/>
    <dbReference type="SMR" id="A0A1D8PG96"/>
    <dbReference type="FunCoup" id="A0A1D8PG96">
        <property type="interactions" value="1403"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PG96"/>
    <dbReference type="GeneID" id="3638830"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201120WA"/>
    <dbReference type="CGD" id="CAL0000199653">
        <property type="gene designation" value="KAR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01120W_A"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PG96"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034099">
        <property type="term" value="C:luminal surveillance complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070972">
        <property type="term" value="P:protein localization to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0000199653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AOW27160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="687" mass="74562" checksum="887A7270AD455D6E" modified="2017-01-18" version="1">MRSSQSSWLPRIGLLYVALVILIPFLVSPKHAFAVAAVSDDESSTDNYGTVIGIDLGTTYSCVGVMKNGKVEILANDQGNRITPSYVSFNGDERLVGDAAKNQASSNVNNTVFDIKRLIGLKYNDDTVQKELKHLPYKIENKGNKPVVKVEYQGEEKTFSPEEISSMVLGKMKSIAEDYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKGDQEKQIIVYDLGGGTFDVSLLSIEGGVFEVLATAGDTHLGGEDFDFKIVRYLAKQFKKKHNIDITANAKAISKLKREAEKAKRTLSSQMSTRVEIDSFVDGIDFSETLSRAKFEELNIAAFRKTLKPVEQVLKDGGVKKSDIDDIVLVGGSTRIPKVQELLEGFFDGKKASKGINPDEAVAYGAAVQAGVLSGEEGVDDIVLLDVNPLTLGIETSGGVMTTLIKRNTAIPTKKSQIFSTAADNQPTVLIQVYEGERTMAKDNNRLGKFELTGIPPAPRGVPQIEVTFSLDANGILKVEAADKGTGKSESITITNEKGRLSKDEIDRMVEEAEKYAQQDQELKEKIEARNSLENYAHVLRGQLSDTSETGLGSKLDDDDKETLDDAIKETLEFIEDNFDTATAEEFEEQKQKLIDVANPITAKLYGGAAGEGAGGAGDAKFGDDDSDDEFDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGA1</accession>
    <name>A0A1D8PGA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">VPS54</name>
        <name evidence="12" type="ordered locus">CAALFM_C201170CA</name>
        <name evidence="11" type="ordered locus">orf19.9558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719456.2">
        <property type="nucleotide sequence ID" value="XM_714363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGA1"/>
    <dbReference type="SMR" id="A0A1D8PGA1"/>
    <dbReference type="FunCoup" id="A0A1D8PGA1">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGA1"/>
    <dbReference type="GeneID" id="3638860"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201170CA"/>
    <dbReference type="CGD" id="CAL0000193179">
        <property type="gene designation" value="VPS54"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01170C_A"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGA1"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="822"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000193179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW27165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="978" mass="109388" checksum="E0A351AC4AD75CB0" modified="2017-01-18" version="1">MTDDSLNLPSRVSMDDSSINLNDDLVVPSENSSNSVLSSTSNVNTRTPTTIITNNNNNNHIHRGHRRTGSAISTNYRTSIDNESYISSGTFFNFANLEDQKDDIYSPLGPNSIYALTIGSDIARAKRHRAPKTNVTLIGGATTIYHVNTPTTKDIPQIQLVKLKNKVSSKELDEKYVKNIASEYKKFESSYNPLTEDILSKLAQNERKSSITSSTSSLPSPSPSSPTTIDNLKGLSTQLDAIPQVFQESDFRLDDPRVFKQVLKGTTLMFDENDPNSSITNNTELQEKLSDYLDIVEMNLVDEIAKSSDSFFSTFGDIENIQKKSTECVTNYHTLMNKIDQLEKNQSRKGLDILHKMIERKNVETLEQSLLQIQYITSLFQLANKSFTHGDYSKGLNQISAVENLLKGVDHEDITDEETQKIYPKLNLIDLSYLPAFIHLQNDLATLKRECSKGYIDGFVELLVEDLRSHFNNVPVKDTLNRIYVNKDKTKKYNSNPINTTYLNFDETTKATLREFVSNLAKAGSLSQAYSNYQSKFITEIKDIIKQNLPLQKSTDMSNTSSRASPISNAEPVPPKQSNALSSNIKTLTPKEFENMLSKTYAQLSECLRRLTVHQKLLLDIALTSIPPTSDIDIMSLDITNAIHKAIELTQIRLMKVINVRSEQTGDLPIPFYFRLYSITSAYLQECEMINPAFAFNGAGNVLSEWFNNHVNYFVHRVHVNSVKSMINECMKENWKITDKSDLFAPAQTIINEFIGYGEYITSNGSSGFSGDTWLKDFDFYESDDQEKDTTEDKNGGEASSSSGSGSGSGSVSTKKLTIGEQEFSVPSLVLKALPHIKDYLVISKAFPNYTSTIENNLLTYFKDMNSKASQAVLGAGATKTAGLKHITVTNICVCYLFLEVVMKIMDILTVSEVDFDDVMGSYKEHQNQLVLKIGMIVRDRGASETVGKILHRVLGDERAERIMSELGIGTPQPVSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGY4</accession>
    <name>A0A1D8PGY4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">STE11</name>
        <name evidence="15" type="ordered locus">CAALFM_C203770CA</name>
        <name evidence="14" type="ordered locus">orf19.8464</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720968.2">
        <property type="nucleotide sequence ID" value="XM_715875.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGY4"/>
    <dbReference type="SMR" id="A0A1D8PGY4"/>
    <dbReference type="FunCoup" id="A0A1D8PGY4">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGY4"/>
    <dbReference type="GeneID" id="3637369"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203770CA"/>
    <dbReference type="CGD" id="CAL0000193264">
        <property type="gene designation" value="STE11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03770C_A"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGY4"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="PHI-base" id="PHI:11639"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:SAM domain binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:cell integrity MAPK cascade"/>
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        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
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        <property type="term" value="P:pheromone response MAPK cascade"/>
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        <property type="term" value="P:signal transduction involved in filamentous growth"/>
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        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
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        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ras-bd_By2"/>
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        <property type="entry name" value="SAM"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ras_bdg_2"/>
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        <property type="entry name" value="SAM_1"/>
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        <property type="entry name" value="S_TKc"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="545"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50105"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000193264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW27406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="823" mass="91347" checksum="44886CC6262656CE" modified="2017-01-18" version="1">MTEINDSTENITRIDRNDAKELKHWLAKANCQHHYSKFIENGITMDLLPELDTGSLKELGISKLGDRLRLEIAISNLKAENLKELISVDEIYQLLNLNPQPSGSLTNLNNNNNSLLDVSNSNEGTLTQLSQNNSSNNLPISSMNSSTNNINGNTINSSSGNVVGNSASSKDSSKTITFILQDGSTKRVNATGCFNAQAIKRRVLKKLGFKPDEIQFDTYVHSVPHGVENVLYGKTEPTITLLYDVELVTICYSPERLEKYRIMLVPKNEPPTPAAIETSKKIMSKYKKQVSGSKAELQEEVNQLHTKDVQAHRSTLRNFFGQRPPSELISSNLAEYFPDTRQKDLEQTVRNSVRHSVRLSRRFNLPAGAFSSSVYSLNKRQSILSNSTGFPSNRTMSISSGEQQSGVFNTSGGGSGGLRRAQRTIGDVMVNSITAIDEVVNSNDTFSVFNKPSTSFSNQPVQPLNNHDSRSIISSKSLSGGTALHRISISPNYNDNPAHDRHSTIELLNPSDSEGEDGEEDGEFGISDYAGLSSSSGENGPPENWLKGARIGSGSFGTVYLGMNPFTGELMAVKQIPLVNENGNNSDTENIQNSMQEQQREMMLLKELNHENIVRYFGSTTDENFLNIFLEYVPGGSVQSMLNSYGPFEEPLIRNFVRQVLIGLSYLHGEDIIHRDIKGANILIDIKGTVKIGDFGISKKVSAIDEEDEDFKKTGKRASLQGSVFWMAPEVVKQTTYTKKADIWSVGCLIVEMFTGRHPFPDLSQMQALFKIGNHITPQIPEWCTNEAKEFLKKTFEINFEMRPDAIELLAEQFLNPLIMSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH42</accession>
    <name>A0A1D8PH42_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">BAT21</name>
        <name evidence="18" type="ordered locus">CAALFM_C204230WA</name>
        <name evidence="17" type="ordered locus">orf19.8417</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:31763"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:31765"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720921.1">
        <property type="nucleotide sequence ID" value="XM_715828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH42"/>
    <dbReference type="SMR" id="A0A1D8PH42"/>
    <dbReference type="FunCoup" id="A0A1D8PH42">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH42"/>
    <dbReference type="GeneID" id="3637356"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204230WA"/>
    <dbReference type="CGD" id="CAL0000175657">
        <property type="gene designation" value="BAT21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04230W_A"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH42"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
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        <property type="term" value="P:branched-chain amino acid catabolic process"/>
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    </dbReference>
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        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
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        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
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        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060556"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000175657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW27449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="393" mass="43863" checksum="B6113819156B9057" modified="2017-01-18" version="1">MILKTSSLLRSAVQPRQWLRYTSTVAPLEASKLIVEKTSNPKPKLPKDKLVFGKTFTDHMLEIEWTKEKGWHTPKISPYHNLSLDPSTIVFHYAFELFEGMKAYKDTNGNIRTFRGDKNMIRMNKSAERIALPTFEGEELQKLIDKLLLLDQDFVPEGKGYSLYLRPTLIGTTASLGVGTPDRALLFVIASPVGPYYSSGFKPVSLEATDYAVRAWPGGVGDKKLGANYAPCVKPQLEAAQRGFHQNLWLFGDEGYVTEVGTMNCFVAFENDDGTKELVTAPLDGTILEGVTRDSILELARERLPSDEWTVSERKYTIYEIEEKANKGQLIEAFGAGTAAVVSPINNIGFRGKNIKVPVALGNSGELTATVAEWIRKIQYGEEEFKNWSRVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH57</accession>
    <name>A0A1D8PH57_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C204400WA</name>
        <name evidence="2" type="ordered locus">orf19.11988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712939.1">
        <property type="nucleotide sequence ID" value="XM_707846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH57"/>
    <dbReference type="STRING" id="237561.A0A1D8PH57"/>
    <dbReference type="GeneID" id="3645457"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204400WA"/>
    <dbReference type="CGD" id="CAL0000189141">
        <property type="gene designation" value="orf19.11988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04400W_A"/>
    <dbReference type="eggNOG" id="ENOG502RPWR">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4090559at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000189141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="396" mass="44596" checksum="BA331FDCC2B43662" modified="2017-01-18" version="1">MINDNIYKSIHSMASATGPTATGISHGANPADDVNNTDPNLKRISQFILLGAAEATGNRHHNLHDGKSELSYESSLDIMSVQNNEELKDEFDEFIEIPTLVSDNESEEIESIATKTSAPHWKSQLSLQPTPATSQSGSNREGVQAARFNVQSANNHQHQPVVHQHTSIQRANIKRGILATRKNNQQPAITVDDVKQSINSTTTTTTTTTTASTSKQSSLECSQEQFKLERTKIMTIVIKYVTAKIHNSFPPDSGRNVKQNELPLDKFLLILTSRLRITSPVFLKAIIYLFRYMDIIYLLRYLNQTNNFVNYNDMGFELKKLIVGCLKLAIIKENRITKNKYVLNWEQITGLKNQEINSIVKTLVGRMNGKLNIKDVEVANMKNEMFRFVKMISTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHN5</accession>
    <name>A0A1D8PHN5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">RTA3</name>
        <name evidence="12" type="ordered locus">CAALFM_C206460WA</name>
        <name evidence="11" type="ordered locus">orf19.7694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711830.2">
        <property type="nucleotide sequence ID" value="XM_706738.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHN5"/>
    <dbReference type="FunCoup" id="A0A1D8PHN5">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHN5"/>
    <dbReference type="GeneID" id="3646566"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206460WA"/>
    <dbReference type="CGD" id="CAL0000189971">
        <property type="gene designation" value="RTA3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06460W_A"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHN5"/>
    <dbReference type="OMA" id="IMGGIYY"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061091">
        <property type="term" value="P:regulation of phospholipid translocation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000189971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW27650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="464" mass="52261" checksum="9108FD4796965FA6" modified="2017-01-18" version="1">MNTMDLAVITEWTPTSTATSTTLSTIAATYAPALQSKISGAVHTLTSKGSTIANMDYISASRIIRGAQASLSIISAEHVLETATATDVQAQATQIIWQATENLLDLAWEENVYDIPRLNRTANILFLVLFAITFAIACLMWIKSRYWWFNVAWTCGTALEFLGYLGRVLSFSDMKKFDYYLLQLIALTLSPVFLMAGIYFLFGQLVVIHGRQYSWLKPLHYSYIFITCDVVSLVIQAVGGGMTAIAAQEYDDVDPGTYTMIAGIAFQVFSMSVFLLCWLVFCWNIYFRDISVNESKPSPYQKKSFMTFIKLLLNGDDANMYKLKVLDKYYNSSYKDLRRRPLYNYYAIAITLAVIAVYIRCIYRVVELAQGFSGYLITHEVYIMTLDAAMIGICCIIFILFHPQVVMGSSNVVGLRSIAKNKDQETGDKSYEEKTNNDIVSDNEESTLQGQNIVRGDPIQENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHR9</accession>
    <name>A0A1D8PHR9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">YPT72</name>
        <name evidence="8" type="ordered locus">CAALFM_C206910WA</name>
        <name evidence="7" type="ordered locus">orf19.2245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714835.1">
        <property type="nucleotide sequence ID" value="XM_709742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHR9"/>
    <dbReference type="SMR" id="A0A1D8PHR9"/>
    <dbReference type="FunCoup" id="A0A1D8PHR9">
        <property type="interactions" value="974"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHR9"/>
    <dbReference type="GeneID" id="3643523"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206910WA"/>
    <dbReference type="CGD" id="CAL0000178686">
        <property type="gene designation" value="YPT72"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06910W_A"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHR9"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036187">
        <property type="term" value="P:cell growth mode switching, budding to filamentous"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000178686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="217" mass="23838" checksum="0360E4644338035B" modified="2017-01-18" version="1">MSSSSRKKTLLKVIILGDSGVGKTSLMQQFVNSKFSHQYKATIGADFLTKEITVDNNKSVTLQIWDTAGQERFQSLGVAFYRGADCCVLCFDVTNEKSLNNLTSWKDEFLVQSNVSNPQDFPFIIIGNKIDVDDSKKIPSLSKKLNNITNNQMGGLNYPVFETSAKDGVNVEAAFEVIAKMALQQEELNASNGNDVNDDYNDAINIHLDSEASACGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHT6</accession>
    <name>A0A1D8PHT6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C206930CA</name>
        <name evidence="3" type="ordered locus">orf19.9787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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            <dbReference type="PubMed" id="17419877"/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:protein maturation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
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    </dbReference>
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        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
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            <begin position="651"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000183277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1084" mass="125134" checksum="51771912D10C2C17" modified="2017-01-18" version="1" fragment="single">MISDIFFPFLSFIIENFYFSFRKPTTTTTTTTRSKILHQTPKQMSEHNIPILINQYIAASSGNDEEAVSNYIFELSNLISNDELSLLQFIQHLGPSLTSDKDSIRSKSIECLSKTIISLSDSKLTKQDINVLIEFLLNKLIDNDQICLQYSLMGINSLICKKNFLGDTNIEKILQQLYKNYDPKKNLAKVRYETFQILLNLLNQFNQYLNSSSIQLSNLYIKTFIHIASGEKDPRNLLISFELNNKINANFQFDNKNNELHQQFITDLFDICFCYFPISFKPPSNDPYKITSEQLKLALRETIASQSKFAPEAFPSLIEKLTSTNPTIRNDTLKTIELCIKNYSKNDATVIEEYWMTIWNALKFEILHNDISSNFNPTNNTIVASDYDEIDDNDEFKPLVLTLVILNRLISTLSQPEIMLHTVVEELKPNLEVMKEKSIKSSLILSSLGSTSVDNLNYIVDFLFQYQIWGKFLNIDKKEENEEQQEFDTNEDVSLNIAKQRDLIDSIGFVLTAYQVLKPTAHCHLLDYKDYILIFLGQLLTITSNLEKTLKCKIIQQLIKLIKLPGYLNTNELELILGNYFKQFFLDTTKTSGKKDVILQEIINGLIEVSQDSQITSLTIEFIINPILNQLLTTEDNDGGDVNIETFQFQLEIVGDLCINYQILEVISIRLLNKLPIINNQSNNNLQLYKIIINLFIELIKKIESIQQFLTNSWYKNFIPKFMENLLIVLPLENILHNNDDNYELFEIVGDLLGLIIKFIDVSKHQEILDQLNQTFIINNNDDDDDDEETNHQGPFKYPSNLLIEPNNYINVYNKILSSIDKTCVFKQDVDQQVIESIINLIYKIGNDDEYLRLQYLQTLCLLINKFTNNADFIESKLKFLEKVEEQDFPITKKDFISFEIFIWILKGLIVKLDKLGINYLNQLLELFVITENYKLKQLIGKSLQILFIDLKIFTNERITTTDNTNSTNGGIKSSSQLISKVKNLQVKSLYKQHIFVIILPYLINDSNENFTNDADFNLKFNSLSLIIENLSINGNNNILINQLSEILPITLYSLIKIPIDANSNSNLLASLIILNIILKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJY8</accession>
    <name>A0A1D8PJY8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dur35p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DUR35</name>
        <name evidence="9" type="ordered locus">CAALFM_C304570CA</name>
        <name evidence="8" type="ordered locus">orf19.13336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723128.2">
        <property type="nucleotide sequence ID" value="XM_718035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJY8"/>
    <dbReference type="SMR" id="A0A1D8PJY8"/>
    <dbReference type="STRING" id="237561.A0A1D8PJY8"/>
    <dbReference type="GeneID" id="3635150"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304570CA"/>
    <dbReference type="CGD" id="CAL0000176697">
        <property type="gene designation" value="DUR35"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04570C_A"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJY8"/>
    <dbReference type="OMA" id="CCYLTTK"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF3">
        <property type="entry name" value="DUR32P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000176697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="668" mass="73312" checksum="4AAAD88100E63892" modified="2017-01-18" version="1">MSESAVHLLDQAAGYGVLVGVGALFAGGMILTTFLLQRYLHENANSTETFAVANRSVGTFLSASAVYSSWSWSTEFLLVSSMTYNYGIQAGYYYGAGLAIQIAVMSVIGIHAKKKIPTAHTSLEAIELRYGKSAHLLYLTLSLICNICSCSAMILACASGISIIAGNLHIVASTLLIPFGVLLYTVVGGLKATFLTDFVHSSILLIILCYLNTSVLTSEQVGGLNGLYDKLLKVSATKHIEGNYDGSILTGKSQGAAIFGLILTAGNFGLSIMDSSFWQKTFSARPRSTVPSYLITAFLICSNVWPLSAIIGGSSHFLETDPSFPTYPRKMNQYEVDSGFVLPYVLKATIGNGGVGALLLIFYLAVTSTVSAQMVSVSSIVTFDIYKRYFKPDAQNKSMIRVSHITCIVFGFGIAGFSIMLHYVGINMTWYTYFYPILICPGVIPIILTVTWDRQTFWAAFISPLAGFAAGLAVWLSTAYHFYGEVTIASTGGQLPALYSSLTALLLPGVLSIIISLIKPKKFDWNQLKKADLLVKSDDSSQDEQVSETDREKVEKNDQVEVNVDSDRNSSLEQQEHPTKLTEKELDFWIKIATGAAIFILLITWLIWPMSVYRDWIFTPTYFKGYVTVGLIWLYVTLIVIGVIPFYTGRHSMAKVFKGVYNDYIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL32</accession>
    <name>A0A1D8PL32_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muc1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">MUC1</name>
        <name evidence="4" type="ordered locus">CAALFM_C400600CA</name>
        <name evidence="3" type="ordered locus">orf19.11659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Weissman J.S."/>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2024" name="PLoS Biol." volume="22" first="e3002693" last="e3002693">
            <title>Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the transcription factors Zcf15 and Zcf26.</title>
            <authorList>
                <person name="Rai L.S."/>
                <person name="Chauvel M."/>
                <person name="Sanchez H."/>
                <person name="van Wijlick L."/>
                <person name="Maufrais C."/>
                <person name="Cokelaer T."/>
                <person name="Sertour N."/>
                <person name="Legrand M."/>
                <person name="Sanyal K."/>
                <person name="Andes D.R."/>
                <person name="Bachellier-Bassi S."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="38905306"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.3002693"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Transcription factor that, with ZCF15, plays a key role in reprogramming cellular metabolism by regulating central metabolism including glyoxylate and tricarboxylic acid cycle (TCA) genes which is important to control biofilm development (PubMed:38905306). Binds to the 5'-WWWHTCCG-3 consensus sequence found in the promoters of 70 up-regulated and 87 down-regulated genes, including the glyoxylate and the TCA cycle genes, namely IDP2, KGD2, MDH1-3, and OSM2. Binds also to the promoters of genes of the glycolytic pathway such as TYE7, encoding a transcription factor and PFK26 that encodes a 6-phosphofructo-2-kinase (PubMed:38905306).</text>
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            <location evidence="3">Nucleus</location>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02180C_A"/>
    <dbReference type="eggNOG" id="ENOG502QVYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLH4"/>
    <dbReference type="OMA" id="RNPFVLY"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463354" description="Zinc cluster transcription factor ZCF26">
        <location>
            <begin position="1"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="38905306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="38905306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="830" mass="95435" checksum="9143DF4FCB274D0C" modified="2017-01-18" version="1">MDVDLDKRTKVSRACDYCKKRKFKCSGVSPCELCTKKGIQCEFNIVDRRTIRRKNKKRTIRNKPATATSSTTSKIKKDENQIDKTTLKMLTRNSKVPVQLQPLLSFPLHKLDNKQNEEEKHTQQSPPAADDTPDDERKDKDRKIDKKTHPDPPKNERAPPKVLYDSEGNLRYVGESSPLSFLFECRNIFLDRIGESDFTSESDSLEVIDEPDESTEIVQVALPSRQLLNEIVRIFYMNIQQATYFVNVEYFKENSINPVYENYSGCDPEKIALVNLVIAIGLLHAEATNDPVLSQLQSPTMRSSAYFEFGFYLTKMNMNKGKLWLTEAFSLAYCYYQAKQQRNTAWLMLGMAIRNAQALGLNRKFINESFKDRSYIVHRRRLFKTLYILDRITSILLGRPLIIDDYDWDDFDSEDVYDRDLDGNLIKDTRFECMIQACKISKLLGKVVRNYYSDGIINPYKAEKLAIELKLWSLSLPEPLQIDKIFNPSNPPSKIAEPWIDHKVTLLLLHLSQLYAIVLLSRPFFMYLIFDKKKKRKILKRPKTRPEVAMHNFCKATAKSSALIIQLVENYINTIRITSGRAESHGLTHTCFMATLIIGLSLLYLEDNGYTLKDGYSSCKQMSYLNSAKKIFEYYSQTNPISSRFYNIVEQMQLALMNKFNLDMDGNRINIKKQPQQKHENGASSTTTNETTIPTESFGVGTTDIPFNEDYDNFIDNFGNLLPTTTNQQHSTNNNMPFFMTAQPYQNTPSAYSNVSEELGNHQQQQAYPQQSPQLPDHVQQNQYLSQFSPTLDSNNLVSGHTSLGSKNQSESLDAFMYNVGLNDILYNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMR2</accession>
    <name>A0A1D8PMR2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">TRP4</name>
        <name evidence="13" type="ordered locus">CAALFM_C407090CA</name>
        <name evidence="12" type="ordered locus">orf19.10611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715408.1">
        <property type="nucleotide sequence ID" value="XM_710315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMR2"/>
    <dbReference type="SMR" id="A0A1D8PMR2"/>
    <dbReference type="FunCoup" id="A0A1D8PMR2">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMR2"/>
    <dbReference type="GeneID" id="3642904"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407090CA"/>
    <dbReference type="CGD" id="CAL0000182715">
        <property type="gene designation" value="TRP4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07090C_A"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMR2"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="87"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000182715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="369" mass="39481" checksum="E56AE33DB15027E4" modified="2017-01-18" version="1">MTTSSKNALTPYLKKLVVEPPTLEPKDLSEALELIFSDIPSDIQTAAFLSCLRLRGLDQEADYIAAAVTTVLHFAKTIPPELVDSKGYIDIVGTGGDGQNTFNVSTSSAIVAAGMGLPVCKHGGKASTSSSGSGDLLKSLGVDLSHVNEVTTPEIVKKSKFCFLFAPSFHPGMGLVAHIRSQLGVPTIFNILGPLINPIPLRARVLGVYSEKLGESYAQAASILAKKNQTHEKTMVVFGEIVLDEISPIGYTKTWTIDKSGKIERNRISPKDFGLPEHDLSTVKSGTPQQNAEILSHILNQDNDEFKVKQDGNNHPLVDYILMNSAAVAVVSGIADNWVDGVALAKESIVSGAAKKALEDFQNSSKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN54</accession>
    <name>A0A1D8PN54_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 24" type="primary">CFL4</name>
        <name evidence="24" type="ordered locus">CAALFM_C501360WA</name>
        <name evidence="23" type="ordered locus">orf19.9488</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001038">
        <property type="term" value="P:regulation of cellular response to drug"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000191657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="922" mass="104086" checksum="7DFC2F2DB33748AC" modified="2017-01-18" version="1">MSDVNDTLNPVYTQDGEKRLRTKVACDYCRKRKSKCNGEQPCSKCLDKNRNCTYTFVQKERKRTQRKPTAGAENKNNGAIRKARTTSAATIRQLTSRINVLESLLGRLVDKLDPNVKSELSEELQSSSFTNGNNDSREKHNGSSSNSSDNGDDEENDLQEAHEGDDSDDKNNSDGSIEYNHNDENSKQIDTKSSNDNEVRKLRDMLAPAEKSCVSNIKNRLMQYFGSHALFFSISGRAVEWLRSRVQGSNANNMNDIFAPLRHVPLSLNDAVQKSTKLLNGPDVETDKKRQFDDLEKSLIFEIIDKYYKDLYWAPFLCDVSTIRELFQIYFYGAQRNDAAILGNITYSDLLIMNIALVLCLANISRDDVIDSLEYPNLSTKSVSYLQSELLNKLFLNAMGAYGKVSRNSDGIRSLQGLALLILYFEINFVTDFHVNYSITSVLIRYAKESGIHRVETLNNDNGVEATLKRKLWWFCEYKGVDITYKSGKPILIDMDDVTTLTEVDDFFMSVPTTLFLNGKYLENANDIVLNSQIHGGEYYFAYFLLILSRIKAKSYAKIYSKLPTNINIQAALTFVNEFDYDLRILTNLMSPILAATTTISSPNSTTVKNPLNLSEGCFNYFKVELLLSQYAHQLSINRVPFVKSFGINDSRLIPYGNQSLAGARSMLELIKDIGSLKISQRMYSALSFYPLAAFCSLLGNCLVFPSEPSAVDNSVLLANVAISFFRSEGCNNKIDNKRSIYDILVRLLLRVLIDALKNLAKVDLYEKIPELEYHINSMFTLFPEVFANQQDQIISLMSERNSNNENANQHSNMIENGSSSIGCSSSSTSSSNTIIDSDYQKMDLDVKNSTSLPQSFMNTPGMLNIDNGNMMLMNGNYDLFSNINFENIMSDETFNNMIFSELNELPDFFNSPSLGFNEQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNB4</accession>
    <name>A0A1D8PNB4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DOP1</name>
        <name evidence="11" type="ordered locus">CAALFM_C502050WA</name>
        <name evidence="10" type="ordered locus">orf19.10675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714584.2">
        <property type="nucleotide sequence ID" value="XM_709491.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNB4"/>
    <dbReference type="FunCoup" id="A0A1D8PNB4">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNB4"/>
    <dbReference type="GeneID" id="3643768"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502050WA"/>
    <dbReference type="CGD" id="CAL0000178632">
        <property type="gene designation" value="DOP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02050W_A"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNB4"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="8">
        <location>
            <begin position="335"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="9">
        <location>
            <begin position="1206"/>
            <end position="1650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000178632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1669" mass="190171" checksum="22B6DFF30F4CD990" modified="2017-01-18" version="1">MSSLLSKTKLSPKDKKYSQSVEKTLATFDSLEEWADYIAFLSRLQKSLQLNIDTAKESYYVPYSSQVSNRLALCLSSDLPNGVHQKALSVYEYIFDRLPESTLNKDINIWLPGLLPLFSYSSISVKPLQIKMFRHLILSQLSATTLCGISKPFILCLLAGLDDENSEVFGDVIELLDAYKSKLNNDSHFWQSMFVCIIRNPERRLGALHWCVKRLPSFISFKDQNGKTVLSEEAQLCLKPEPGLLIRAMAISIDNPESFDVVVVRGFFDLMLSHIPLDSDVITNRITPTDREVLIMACSKITLRKDMSLNRRLWTYFLGPETEHESSKALTRTEYFKQYVEETLINGLLAMAHSDKIELKCDAFKILLPLIMDKWEIGNVLTPKLFSSFLKIAYNNRDHQDLMISASTLFDGVESIYIWSDIIGVILSDESDEEEHEFDVVHFVLKDFNVNEEEMATLHVPFAILCLLAKSTVTPKRLDTLELLINLVSARSLDTLDEGVTCCESEIINKIETWYSSSLKGESPNTPFSQGQVSFLIVNLLQKVYVDNMEDTRFCIKVAELLNHVRNFAMIKSSHRIQDSKLVEKILNVSVPDFSCELNNQDGLLVAFGISKLVGIFSKSLNHETNEKVLKVLLSNLWSAVVSSDPANHQVEAVRAIFELETCYSLKKLEAGLVELFLALPENRRVKAFEILWIHSMSINESDRILEKPLQLLLDGCSDASSQNRLPIDEFLKQVIKTGASNRLLKLITNPILAFDFIVAENESLQLDDDLGQFSYFLNLVVKVITADVKSFRDCFNNELAVMDSKTKITLVKDNNWNISTYKSLLLSVIQKFFKLNLATEAFEDREQMQNYYSSIDNCLQILHLLVTGNENDFGDLLMFLIQISLKLSKTGTVSPIIEAVQSKFLQCIFYYLERATELRLNLNLLHVEEQNKNPLLINFICLGISKSESPILLEKWMSLLIKSLYLFGESVFSVLLVLNDTLIKKIDNSFDQFSTWQHFKDPQDFESSVDILFSGLEDLLTISHSYLMTSNIKQQAENQKNSNTDNGFLNTVISGVFQIESPAIRSSEQNKLYSILLAFHDAVRVSFKIWNWSDSKTTTPSTVNYYSDRSLTYISHKLKFRARKLLESLLDMERQEVVESILISNGSVNAKLKLMDILDGGRPQMTLPSILKSILLRSNLPVFSELSRVAVDLDFDLNMKELSRFLVDFLNFIDNDSVADIWNHIMVFFKDVLTHVGAFDEILSDCLLICSGLSKKLTSIKNRDHKYQKELGDIFVRLFNQVLNLKQFLVSDMSKNNTKTTRKGDLVSSKPDLENNFSTLCQIIPVFEDILPDSDKVSSLANLTVTNFIIARTKSKTVSEIPEDVVVIINILGESNSCRSWKTLVSDLFMDKSFFNNTSSMSSVWRSVINSWMVHDKERFGEIISRITVTSGASPSNLFVWNEMSEIENKANLLKRLVYLILVLPKDYFLNYLEPLFDKVNVLLNGNCPDIIRIQIMILFRAVCLKFNELHLLSKWTLITHELLSTFENLLAKSAKELSTLSQDSLQLIFFGCKLLDQLLILSYDEFNLKECLFVSTSPDLDDGESISIISKISKKYDLTYLKDEPFKVDQASGSLRPLLEGKRKIESLTQLRLFFDSLGLINYERTYSLYPIDYDSCTTDALSDLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNG6</accession>
    <name>A0A1D8PNG6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">UAP1</name>
        <name evidence="8" type="ordered locus">CAALFM_C502530WA</name>
        <name evidence="7" type="ordered locus">orf19.11741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720573.2">
        <property type="nucleotide sequence ID" value="XM_715480.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNG6"/>
    <dbReference type="SMR" id="A0A1D8PNG6"/>
    <dbReference type="FunCoup" id="A0A1D8PNG6">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNG6"/>
    <dbReference type="GeneID" id="3637769"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502530WA"/>
    <dbReference type="CGD" id="CAL0000180804">
        <property type="gene designation" value="UAP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02530W_A"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNG6"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052630">
        <property type="term" value="F:UDP-N-acetylgalactosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019276">
        <property type="term" value="P:UDP-N-acetylgalactosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-N-acetylglucosamine diphosphorylase 2"/>
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    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
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        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000180804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="486" mass="54622" checksum="E975A4EFC9FAF9FB" modified="2017-01-18" version="1">MTVKSQHPIIDSFKQANQDQLFQYYDSLTINQQQEFIDQLSTIEEPAKLISTVEQAIQFSQTNSTSRNFTQLPNEQTASTLDLSKDILQNWTELGLKAIGNGEVAVLLMAGGQGTRLGSSAPKGCFNIELPSQKSLFQIQAEKILKIEQLAQQYLKSTEKPIINWYIMTSGPTRNATESFFIENNYFGLNSHQVIFFNQGTLPCFNLQGNKILLESKNSICQSPDGNGGLYKALKDNGILDDLNSKGIKHIHMYCVDNCLVKVADPIFIGFAIAKKFDLATKVVRKRDANESVGLIVLDQDNQKPCVIEYSEISQELANKKDPQDSSKLFLRAANIVNHYYSVEFLNKMIPKWISSQKYLPFHIAKKKIPSLNLENGEFYKPTEPNGIKLEQFIFDVFPSVELNKFGCLEVDRLDEFSPLKNADGAKNDTPTTCRNHYLERSSKWVIQNGGVIDNQGLVEVDSKTSYGGEGLEFVNGKHFKNGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNX4</accession>
    <name>A0A1D8PNX4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C504340WA</name>
        <name evidence="3" type="ordered locus">orf19.11402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721830.1">
        <property type="nucleotide sequence ID" value="XM_716737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNX4"/>
    <dbReference type="SMR" id="A0A1D8PNX4"/>
    <dbReference type="FunCoup" id="A0A1D8PNX4">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNX4"/>
    <dbReference type="GeneID" id="3636481"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504340WA"/>
    <dbReference type="CGD" id="CAL0000188924">
        <property type="gene designation" value="orf19.11402"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04340W_A"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNX4"/>
    <dbReference type="OMA" id="QVASVNC"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019153">
        <property type="term" value="F:protein-disulfide reductase (glutathione) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111194" evidence="1">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000188924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="299" mass="34633" checksum="67CB18F5B0A83FE0" modified="2017-01-18" version="1">MIFNYLLALFQILVLASARAQADEYASDPNIFELTPSNFDKVVHKSNYTTLVKFYAPWCGYCQKLQPVYHKLGKYINKDAKYSINIASVNCDKDYNKQLCSQYQVRGFPTLMVFRPPKYEKGKQVKLQKHASEVYQGERTVKSITKFLTSRLKNYVKKFHNIRSDGIAEWLAEDIPSVLLISNANSVSPLLKSIAIDFLDRVNVGMISKFNDESHKFVIGDKEIEVPATSKSSLFYFNKEKGELVAYTKSDKLNDKIKITEWIIEQTQQQPIEGPLSKKEKKYYYKYRTGKKKIEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP50</accession>
    <name>A0A1D8PP50_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DUN1</name>
        <name evidence="9" type="ordered locus">CAALFM_C505100CA</name>
        <name evidence="8" type="ordered locus">orf19.11485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330983.1">
        <property type="nucleotide sequence ID" value="XM_019475438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP50"/>
    <dbReference type="SMR" id="A0A1D8PP50"/>
    <dbReference type="FunCoup" id="A0A1D8PP50">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP50"/>
    <dbReference type="GeneID" id="3636494"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505100CA"/>
    <dbReference type="CGD" id="CAL0000178305">
        <property type="gene designation" value="DUN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05100C_A"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP50"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000732">
        <property type="entry name" value="Protein serine-threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="59"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000178305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="530" mass="60381" checksum="CB169D040AA6B9D6" modified="2017-01-18" version="1">MSLIRKRKLKELEQEQEQQHGSKTQHTPAHDSSEVELIGRLYNVNEKGTNLDIPKKSVVIIGRSSSCDIRIQGIDVSSKHCQLNIIQTTNKHINTRSEYLSITDLSSNGIKINDESMSKRTSIILKTGDKIAFAKTGGCYIFRYIISDQEYNEEDDGNVQLKKKKKYASFFDDYILGKQLGSGHYAVVKEAKDKKTGQAVAVKIFHPNKSGLVNKANSAQQQQEDLKLQQEMNLLLSIDHPNIVKFINHYVEPINNYSVNTYLVLEKMNSGELFQRIINKSKLRIDETKAIFRQILSGLKYLHDHDIIHRDIKPENILLDITPKTSPHQKSMGPWDKDEFDIKVKIADFGLAKFIGELKFTNTLCGTPAYVAPEILKPNCRKYSTKVDLWSSGVLLYVCLCGFPPFSDELGPPNMKEQILTGQYAFYSPYWDEISDVVLDLISNLLIVDPNERFNVEQTLNHFWFNEKEQDSLDNSEGAEESQIVEESSCFSSSSQPSSMINGTKRLMIRSNTQPITLKEQHESQINFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPC8</accession>
    <name>A0A1D8PPC8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SME1</name>
        <name evidence="14" type="ordered locus">CAALFM_C600530CA</name>
        <name evidence="13" type="ordered locus">orf19.4205.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330986.1">
        <property type="nucleotide sequence ID" value="XM_019475441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPC8"/>
    <dbReference type="SMR" id="A0A1D8PPC8"/>
    <dbReference type="FunCoup" id="A0A1D8PPC8">
        <property type="interactions" value="960"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPC8"/>
    <dbReference type="GeneID" id="30515326"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600530CA"/>
    <dbReference type="CGD" id="CAL0000200122">
        <property type="gene designation" value="SME1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00530C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPC8"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000200122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW30001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="86" mass="9742" checksum="DC59F3A5C720901B" modified="2017-01-18" version="1">MSSKQTKQTNLPPINLIFKFLQQSSVVTIWLYEQTQSRIQGKIRGFDEFMNIVIDDAVELSNGKKSELGRILLKGDNITLISSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPH4</accession>
    <name>A0A1D8PPH4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">GPX1</name>
        <name evidence="10" type="ordered locus">CAALFM_C600860WA</name>
        <name evidence="9" type="ordered locus">orf19.7732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714296.2">
        <property type="nucleotide sequence ID" value="XM_709203.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPH4"/>
    <dbReference type="SMR" id="A0A1D8PPH4"/>
    <dbReference type="STRING" id="237561.A0A1D8PPH4"/>
    <dbReference type="GeneID" id="3644011"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600860WA"/>
    <dbReference type="CGD" id="CAL0000186690">
        <property type="gene designation" value="GPX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00860W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPH4"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000186690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="229" mass="26480" checksum="98976948CD3D265D" modified="2017-01-18" version="1">MVKSNVESAWETMEDTFSEIQNKFHQIYKPIDTGKPDEDDETTKKESLDITDDSTLSVSPITQLLYLARSKFYDLTPLDNQKSPFPFKNLRGKVVLIVNVASRCGFSFQYNGLEQLNKRFANDDFVLLGVPCNQFLWQEPGTNDQIVTKCKKKYDVSFQILDKINVNGEQADPVYKFLKAQKEGLWGTNRVKWNFEKFLIDKNGRVVERYSTFTRPVAIIPKIEQLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPR9</accession>
    <name>A0A1D8PPR9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C601850WA</name>
        <name evidence="5" type="ordered locus">orf19.10902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716709.2">
        <property type="nucleotide sequence ID" value="XM_711616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPR9"/>
    <dbReference type="FunCoup" id="A0A1D8PPR9">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPR9"/>
    <dbReference type="GeneID" id="3641629"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601850WA"/>
    <dbReference type="CGD" id="CAL0000192008">
        <property type="gene designation" value="orf19.10902"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01850W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPR9"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="689"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000192008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="764" mass="87101" checksum="D33EE55E4D907A63" modified="2017-01-18" version="1">MSDSEEEEVFESLIATRSRRSNAGLRLKQLIALEEQSNELAATTQFLTEDDENVNLLFQEDGEDEEFIDEEVDNANLEGIDEESGTENENENTTRKRKHTSSDGEEEEEEENDTSNINADEILSDSELSATDSDESEGEKELLKQEKLKKKRLKKQSLIPTIKQPSVKSATLKKKQKRTPLVTADSLLLANRRSSSRAAAVESKQALVDKLKESEARRAKYVHVERKQQVELTQEERLAEAVETEKANVESLHRFREQEIVKKERQRQLLLSKRIKLHNVIRLVSSETFVKPIEEVNDARRQYEQYMKIKKKLGKKKKNQLAEMMDFPTRMPFTIDYDSPYQRKLLAEKKAQEQQNEIKKLESMNEKLHELIESGDSKKNDNDEENIQLVPSTNINADNHNNIECEPIKVEDSTQEIKADETDNKDESSDKTNTSISEVAPSDETESTKQEKISDTEFNEESENTSQTEENGLTNDNPSEVKKEENEQTNKIEETPVDNNKPDVQNLTTDTPLDETKSTETIKRVKFADEIGESSKEPTPTVETSHQQEEEIFEGPVQRVSRNLIYMIEFDEDKKELRLDPSNIKRILFGKQSLLPASRRFKDVKTILKIGKPENPYAVVKDQKQSLFDPASNITEDDPMFDELKKLPKLGVKQDLVEIVEDKEETESANIVLKTEAPTGLYLPNGNKKICMISGTEVKYFDPSTGIPYSSVEAYKILKSIEQGQIPWLSLTNESNDTGNVELYLGCRDGTARHAQGVPEGFDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPT5</accession>
    <name>RL23A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L23-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL23A</name>
        <name type="synonym">RPL23B</name>
        <name type="ordered locus">orf19.3504</name>
        <name type="ORF">CAALFM_C602070CA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331007.1">
        <property type="nucleotide sequence ID" value="XM_019475462.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="6=1-137"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="6=1-137"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="6=1-137"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="6=1-137"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="6/BQ=1-137"/>
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        <property type="resolution" value="3.10 A"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="6/BQ=1-137"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="6/BQ=1-137"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
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        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="6=1-137"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="6=1-137"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
    <dbReference type="PDBsum" id="7Q0R"/>
    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPT5"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PPT5"/>
    <dbReference type="FunCoup" id="A0A1D8PPT5">
        <property type="interactions" value="1156"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPT5"/>
    <dbReference type="EnsemblFungi" id="C6_02070C_A-T">
        <property type="protein sequence ID" value="C6_02070C_A-T-p1"/>
        <property type="gene ID" value="C6_02070C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647558"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602070CA"/>
    <dbReference type="CGD" id="CAL0000187999">
        <property type="gene designation" value="RPL23A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02070C_A"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPT5"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456529" description="Large ribosomal subunit protein uL14">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="137" mass="14474" checksum="B0EEA698AAD3B2F0" modified="2017-01-18" version="1">MSGSGASGNKFRMSLALPVGAVMNCADNSGARNLYVLAVKGTGARLNRLPAAAAGDMVMATVKKGKPELRKKVMPAIVIRQSKPWRRRDGVYLYFEDNAGVIVNPKGEMKGSAITGPVAKECADLWPRIASNSGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPX9</accession>
    <name>A0A1D8PPX9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pantothenate transporter FEN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C602650CA</name>
        <name evidence="8" type="ordered locus">orf19.12981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719099.2">
        <property type="nucleotide sequence ID" value="XM_714006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPX9"/>
    <dbReference type="SMR" id="A0A1D8PPX9"/>
    <dbReference type="FunCoup" id="A0A1D8PPX9">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="GeneID" id="3639223"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602650CA"/>
    <dbReference type="CGD" id="CAL0000174828">
        <property type="gene designation" value="orf19.12981"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02650C_A"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PPX9"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000174828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55089" checksum="B5200278F4FA85EE" modified="2017-01-18" version="1">MNKALQPLRTLRRIVWGQPPDNPVARSYLFKLDAFVLSYVCLLYWANYLDRANLANAYVSGMQEDLQMKGNELNIINTCFYVGYIVAMVPHNLILLKVRPRYWISICGFCWAVLTLSMYKVHSFKQLCVIRFFEAMFKAVTFAGTHLILGTYYDEELLPMRTAVFTSSGLLGSLFSGVLQAAIYKNMEDYNGIRGWRWLFIIDFLITIPIVIFGFFCFPDEPQISKPFYMTNEEHQLALEKKLSSKDKANSDWNWVSICNRVFRNWHWYLFSFLWVLGGENESFVTNSLMPLWLKYYNYSVEQRNHYPMGQYAVGVVATIISALYIHAFGKGRHHWHMGIIIGIFTTIAAAVFAAKPNNTVAVFVSQYLSAVSFAGQTVFFSWANIVCINDLQERAIVLASMNMFSNAVNAWWSILFYGADTAPEFKKGCWALLATAIASIGVVVVIQVLQAKDKHQSHNDDGGVVAVVMDGESDEVESGGPIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQR8</accession>
    <name>A0A1D8PQR8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C701050WA</name>
        <name evidence="4" type="ordered locus">orf19.7009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720303.1">
        <property type="nucleotide sequence ID" value="XM_715210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQR8"/>
    <dbReference type="SMR" id="A0A1D8PQR8"/>
    <dbReference type="STRING" id="237561.A0A1D8PQR8"/>
    <dbReference type="GeneID" id="3638017"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701050WA"/>
    <dbReference type="CGD" id="CAL0000186178">
        <property type="gene designation" value="orf19.7009"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01050W_A"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQR8"/>
    <dbReference type="OMA" id="HKEATIF"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001355">
        <property type="entry name" value="Uncharacterized protein CaJ7.0123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000186178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="347" mass="38574" checksum="A99DF4DE1FAEED94" modified="2017-01-18" version="1">MSKTVILTGASGYIGQHILGELLDQNYKVIAIVRSQKSSDTLSKLFKQTPKLQFEIVEQFDKPHALDKVLEKHKEATIFISTAAVVTFHAEDYERDVLDPAIDLVKNIFSSIKEHAPQITRVILTSSSASVVGLDKAFSYDAEYSDNDWSPFTREMSTSDGTMAYFASKKLAEKEAWKFLKEEKPNFDLVVIMPALILGPVRFSSELKNGKFPSTSGIIGGLLHLKSDDPIQPMAAGAVDVRDVAKVHVDVITSEKASNQRILVESGKVTNDNIIQTIIDNFPSYKDKLPTPNPVPHSKFVKPKDERSRKIIGFSLRSLGDSVVDLVKQIDQENSVIESIKKLDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR66</accession>
    <name>A0A1D8PR66_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DOA10</name>
        <name evidence="17" type="ordered locus">CAALFM_C702860CA</name>
        <name evidence="16" type="ordered locus">orf19.12642</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716997.2">
        <property type="nucleotide sequence ID" value="XM_711904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR66"/>
    <dbReference type="SMR" id="A0A1D8PR66"/>
    <dbReference type="FunCoup" id="A0A1D8PR66">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PR66"/>
    <dbReference type="GeneID" id="3641397"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702860CA"/>
    <dbReference type="CGD" id="CAL0000173927">
        <property type="gene designation" value="DOA10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02860C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PR66"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000173927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW30633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1139" mass="129302" checksum="E1E4A10CF7A54530" modified="2017-01-18" version="1">MSSTDHTCRICRGEATSSQPLYHPCKCRGSIKYIHQDCLMEWLKHSNKSTEKCDICNSPYKFKIIYDPAMPQYIPLDLIWKKFLQITSSTVFKSISISLYILCIVIQVPLFWKFSGRVYTWAIDGTLPLVNQKFVDALLFGEFDINTYLADKSQTPLQLSLMKLKKFFGCTYFSGVRYLFVAIVANIALFIEREWVVRDEGYLKMLHKKIGKEHRAKLVDMLQNALQGLRTDGNNGDEAAAANLQRLETLATAINDLQNEDRDMNVAARGEAALRRAIDQNQLFGNEQQPILNQFENGIGQHDALPTHNFDAPENLMNGVFNGRNDIGSDDEEDEEQQEEEDDDEEAAVEEDVDVAAAAAAGADGGVVGEFLEAFGVTLTLSTPIYLMFLCNCIVAVYLFLIYLIPHMLGNTIVSITTFLFKLINVTLISYISKHIPFPTYIYEFASSYITSLGTFNPNKGVTLIERIFILGLGYGLICTTIYRLMKFLVSGPKPISGTPRKAFKVLFEISSTAKVFLIFAIEIFFFPVYCGWLLDFCAAPLFVPQFIQTAENGGKVVTFLVSSYFEMMQLPYLRVLLYWASGTLYMLFFALYIGMVRSTILRPGVLFFIRCPDDPNTRLIHDALVKPLSLQLSRIYLTAKVYSAFIIFGIGGVTWGLRYLVTPKDKDYNVFLPIQTPSYFTYLLLAIIVPTLVDSQATVTKYVRQYWERAFEISSHKLRLSHFIVGKPISSERGYVIYRNIWLQLFGSNVQPDYTQPVTRKEALAKFKQDPNAVAFFVPDGNYVRAPANDTISRKFVKKLFVAVSKDDRLLQEVKEAPKRSGYETPTSDEDEDTTTTTTDDAYTIVYRPPNFKLRCFALILMLWIFAIIIILPVLLFAVVLGRPILRANSIIIDQLPHINIDELTNMDWRLTDLASIAIGLAVELQALIYYDKNFAADAPNNAGGNEIQQADPVRGMLLQGNLLNQAFNRLPAPVLYTLPSSMLWIMWILTVHKLCVDQPIRYMTGNLHVEFLLNFKTLLIHFLVSFWTILPALVYVTRRIPVEGQTAWQTLKRCGIIPCLLNFSMVHIPAFIVLYSLKVLDKANISVSFYIWPVLFICFALVKLITEGAKLYTNINNQVKQEKYVKGRAIENVEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRZ3</accession>
    <name>A0A1D8PRZ3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">PRS</name>
        <name evidence="12" type="ordered locus">CAALFM_CR01480WA</name>
        <name evidence="11" type="ordered locus">orf19.10067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718201.2">
        <property type="nucleotide sequence ID" value="XM_713108.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRZ3"/>
    <dbReference type="SMR" id="A0A1D8PRZ3"/>
    <dbReference type="FunCoup" id="A0A1D8PRZ3">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRZ3"/>
    <dbReference type="GeneID" id="3640100"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01480WA"/>
    <dbReference type="CGD" id="CAL0000194318">
        <property type="gene designation" value="PRS"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01480W_A"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRZ3"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
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        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000194318"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="575" mass="66238" checksum="6965099141B5202D" modified="2017-01-18" version="1">MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVKYFTTEDKSTLICAYYPSNRILEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS91</accession>
    <name>A0A1D8PS91_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FG-nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_CR02610CA</name>
        <name evidence="8" type="ordered locus">orf19.10338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715751.1">
        <property type="nucleotide sequence ID" value="XM_710658.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS91"/>
    <dbReference type="SMR" id="A0A1D8PS91"/>
    <dbReference type="FunCoup" id="A0A1D8PS91">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS91"/>
    <dbReference type="GeneID" id="3642566"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02610CA"/>
    <dbReference type="CGD" id="CAL0000187887">
        <property type="gene designation" value="orf19.10338"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02610C_A"/>
    <dbReference type="eggNOG" id="KOG3091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS91"/>
    <dbReference type="OMA" id="NVMKRDT"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000187887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="576" mass="60963" checksum="7BEA6403B1120B3E" modified="2017-01-18" version="1">MFGSTNNTSSGGGGLFGSSNTASSTGGGGLFGANKPATTTTGFGSQPQQGSNLFGSSSNTGGGLFGNQQQQQQQQANTSGGLFGNKPATGGGLFGAQANNTSNTSGGGLFGGQTNNTTNNTGGGLFGGQTNNTANNTGGGLFGGQSNTTGTNTGGGLFGGQQQQQQQQQSNTTTSGGGLFGNKPATGGGLFGGSSTTANTGSTTFGSNQGTTGGLFGNKQPNTSGGLFGNTQQQQTQQPQQQQQQSSGLFSSNTTNNAQPSFSWSQPPQSSNSTATNGNTNQISNLTSGPFGSNTNQQVNNNTYTYTPAINDQLTKIWEQWDPNSSKCALKTYIYNKFSDQEINVLLNQPRPANESAEDWENAMIARPGPNYYPIKVNSFNDVAQRIETQLDYVAKSRVLLNNINQNLDNLSSQHDLENTTRIMKAKSRHTKLSRRLLRLATILAIVKLKGYPLLPEEEEISKQFELLTSKLNDPNSSIGKLSDVFARLAILKERAEEFNYQCENSVNLLNNTLIEGEESTSKKGSVTTAAEQSDSNIEEAIHKLSKVLLKQQMGLNYLNDILEKDIEAVNKISKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSV5</accession>
    <name>RS3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">40S ribosomal protein S3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS3</name>
        <name type="ordered locus">CAALFM_CR04810WA</name>
        <name type="ordered locus">orf19.6312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_706005.2"/>
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        <property type="resolution" value="3.00 A"/>
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        <property type="interactions" value="1255"/>
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    <dbReference type="STRING" id="237561.A0A1D8PSV5"/>
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        <property type="protein sequence ID" value="CR_04810W_A-T-p1"/>
        <property type="gene ID" value="CR_04810W_A"/>
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    <dbReference type="GeneID" id="3647299"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04810WA"/>
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        <property type="gene designation" value="RPS3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_04810W_A"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome R"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.1140.32:FF:000013">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="40S ribosomal protein S3"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
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    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
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    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
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    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000456541" description="Small ribosomal subunit protein uS3">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW31214.1"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="11">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="251" mass="27272" checksum="EC0106D02006A0B0" modified="2017-01-18" version="1">MVNAILSKKKKLVADGVFYAELNEFFTRELAEQGYAGVEVRKTPSKLEVIVKASNTQGVLGEQGRRIHELTSLIVKRFKLSPEGIAIYAERVEERGLSAAVQAEALKAKLLSGLPIRRAAYGVLRFAMGAGAKGVEVVISGKLRAARAKSQKYADGFMIHSGQPTRDFIDIAIRHVLMRQGVLGIKVKIMKDPAANRFGPRALPDAVKIAEAKDEDEVIPAPTVKSYKQTAEDETETDAPVEAEAEVEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT04</accession>
    <name>A0A1D8PT04_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_CR05480WA</name>
        <name evidence="15" type="ordered locus">orf19.3518</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710163.1">
        <property type="nucleotide sequence ID" value="XM_705071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT04"/>
    <dbReference type="SMR" id="A0A1D8PT04"/>
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        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="GeneID" id="3648238"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05480WA"/>
    <dbReference type="CGD" id="CAL0000191490">
        <property type="gene designation" value="orf19.3518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05480W_A"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT04"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015810">
        <property type="term" value="P:aspartate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0000318"/>
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    <sequence length="286" mass="32009" checksum="D23C58F8F7C434B6" modified="2017-01-18" version="1">MSEPKPLPFIYQFVSGAIAGVSEILVMYPLDVVKTRQQLATTNDYNGTINCLKKIVREEGFSRLYKGISAPILMEAPKRATKFAANDEWGKFYRNYFGVTKMNQSLAILTGATAGATESFVVVPFELIKIRLQDKTTKFNGMGEVVKDIVQKNGVLGLYKGLESTLWRHIWWNAGYFGCIHQVRSLMPKPKDSTQKTLIDLTCGTVGGTFGTILNTPFDVVKSRIQAGSTQYRWTYPSILKVAREEGFSALYKGFIPKVLRLGPGGGILLVVFTACMDFFRQYHEK</sequence>
</entry>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31487.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="59" mass="6882" checksum="0C4F49711B41BFDD" modified="2017-01-18" version="1">MHLMYTLDAEGKRIYTLKKISEDGEITKSAHPARFSPDDKYSRQRVTLKKRFGLLPTQN</sequence>
</entry>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="110"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000175685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="110" mass="12398" checksum="7EFBFD92CCA2B756" modified="2017-01-18" version="1">MSGRGGKLVITTTAIITSIYFGINFWKPIIIEQLEKDGNLRKDIEIDHRNSNTAGSEAIDQPKSWQDLRQKINAVIDPEKNFTAEDQKGLQRLKDRLQSSNPNGSSNDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU83</accession>
    <name>A0A1D8PU83_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="10">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="10">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">4-hydroxybenzoate hexaprenyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="10">PHB:PPT</shortName>
            <shortName evidence="10">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COQ2</name>
        <name evidence="12" type="ordered locus">CAALFM_CR10600CA</name>
        <name evidence="11" type="ordered locus">orf19.7643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
            <orientation evidence="2 10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="10"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719402.1">
        <property type="nucleotide sequence ID" value="XM_714309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU83"/>
    <dbReference type="SMR" id="A0A1D8PU83"/>
    <dbReference type="FunCoup" id="A0A1D8PU83">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU83"/>
    <dbReference type="GeneID" id="3639004"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10600CA"/>
    <dbReference type="CGD" id="CAL0000191686">
        <property type="gene designation" value="orf19.7643"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10600C_A"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU83"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000191686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="348" mass="39005" checksum="F443FE668C4F1CDA" modified="2017-01-18" version="1">MLVFRRPVYQLFTRGFAYSRIIRNEAKVPKFSPVELEAARLAREAGLGWLKHFPRKVIPYLELMRLEKPVGTWLLLLPCYWGITMASYSIAAPLWVTTKAIALFSVGALVMRGAGCTINDIWDRNLDNQVARTMERPITSGRVSVPQAVAWLGVQCFAGLAVLLSLPFECFYLGALSLPFVAAYPLFKRFTYYPQAMLSICFSWGCLLGFPAVGAPLNLWVAVPLFISNWIWCLTYDTIYAHQDKKFDIKAGIKSTALAWGDKTKPIMKGLTVAQAGFYGFAGFMNSMGPGFYIAGAYAIARLYNQILKVDLDNPKSCWSAFTSNIGTGFIFWYGIVFDYILLLLGYI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-05-01" modified="2026-01-28" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>P25997</accession>
    <accession>A0A1D8PN72</accession>
    <accession>Q59NQ0</accession>
    <accession>Q59NU9</accession>
    <name>EF3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 3</fullName>
            <shortName evidence="5">EF-3</shortName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic elongation factor 3</fullName>
            <shortName evidence="5">eEF3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CEF3</name>
        <name type="synonym">TEF3</name>
        <name type="ordered locus">CAALFM_C501580CA</name>
        <name type="ORF">CaO19.11629</name>
        <name type="ORF">CaO19.4152</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Nucleic Acids Res." volume="20" first="1705" last="1710">
            <title>Isolation and sequence analysis of the gene for translation elongation factor 3 from Candida albicans.</title>
            <authorList>
                <person name="Myers K.K."/>
                <person name="Fonzi W.A."/>
                <person name="Sypherd P.S."/>
            </authorList>
            <dbReference type="PubMed" id="1579463"/>
            <dbReference type="DOI" id="10.1093/nar/20.7.1705"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="Yeast" volume="8" first="337" last="352">
            <title>Isolation and sequence analysis of the gene encoding translation elongation factor 3 from Candida albicans.</title>
            <authorList>
                <person name="Didomenico B."/>
                <person name="Lupisella J.A."/>
                <person name="Sandbaken M.G."/>
                <person name="Chakraburtty K."/>
            </authorList>
            <dbReference type="PubMed" id="1626427"/>
            <dbReference type="DOI" id="10.1002/yea.320080502"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Proteomics" volume="4" first="3084" last="3106">
            <title>Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Abian J."/>
                <person name="Carrascal M."/>
                <person name="Sanchez M."/>
                <person name="Nombela C."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="15378761"/>
            <dbReference type="DOI" id="10.1002/pmic.200400903"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 301-306 AND 309-310</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ANTIGENICITY</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
            <tissue>Protoplast</tissue>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1992" name="Mol. Microbiol." volume="6" first="1025" last="1033">
            <title>Elongation factor 3 (EF-3) from Candida albicans shows both structural and functional similarity to EF-3 from Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Colhurst D.R."/>
                <person name="Schauder B.S."/>
                <person name="Hyaes M.V."/>
                <person name="Tuite M.F."/>
            </authorList>
            <dbReference type="PubMed" id="1584022"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1992.tb02168.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-148</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (By similarity). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity). Assists translation termination by stimulating the release of nascent protein from the ribosome by release factors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Has antigenic properties.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="Z11484">
        <property type="protein sequence ID" value="CAA77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="Z12822">
        <property type="protein sequence ID" value="CAA78282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S25363">
        <property type="entry name" value="S25363"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711356.2">
        <property type="nucleotide sequence ID" value="XM_706264.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P25997"/>
    <dbReference type="SMR" id="P25997"/>
    <dbReference type="BioGRID" id="1230099">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="P25997">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P25997"/>
    <dbReference type="EnsemblFungi" id="C5_01580C_A-T">
        <property type="protein sequence ID" value="C5_01580C_A-T-p1"/>
        <property type="gene ID" value="C5_01580C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647040"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501580CA"/>
    <dbReference type="CGD" id="CAL0000190871">
        <property type="gene designation" value="CEF3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01580C_A"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="InParanoid" id="P25997"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="PRO" id="PR:P25997"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.20:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000093454" description="Elongation factor 3">
        <location>
            <begin position="1"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 2">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 3">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 4">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 5">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 6">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 7">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="429"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="672"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="930"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="956"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 6; no nucleotide entry." evidence="5" ref="6">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA77567." evidence="5" ref="1">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA77567 and 2; CAA78282." evidence="5" ref="1 2">
        <original>S</original>
        <variation>T</variation>
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA77567." evidence="5" ref="1">
        <original>V</original>
        <variation>F</variation>
        <location>
            <position position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P16521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15378761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="1050" mass="116925" checksum="B37507FE3B595B86" modified="2017-03-15" version="3">MSAASESKYSTEVLSELLSKLQVADNKDEAASNISTFLNSSIVEHDVPVEFFEDLKKQIQSKDAKVSLAALDAYKHIASTNGLSPSVEPYVVDLVSEVAVKAGDKNKDVQTAASDALLAIASAITPTAVKAILPKLIDNLTNTNKWTEKVAILRAVSQLVDTAKAQIALRMPELIPVLSESMWDTKKEVKEAATATMTKSTETIDNKDIEKFIPQLISCIAKPTEVPETVHLLGATTFVSEVTMATLSIMAPLLSRGLAERDTAIKRKAAVIVDNMCKLVEDPQIVAPFMDKLLPGLKNNFANMADPEAREVTQRALNTLRRVGAVGENDSIPEVSTAGDIDVTLNEFNKLVADKKIAKRFDVALNYIAAIAGDLVDEREIQPEAWLQNVLPFATIFLHEKEAKEIIEEFRKRAIDNIPQPPSFEDEEDEGEDLCNCEFSLAYGAKILLNKTQFRLKRNRRYGLCGPNGAGKSTLMRAIANGQVEGFPTQDECKTVYVEHDIDGTHADTTVVEFVIEDGEVGLTKDVVVDKLREFNFSDEMINMPIQSLSGGWKMKLALARAVLKNADILLLDEPTNHLDTVNVAWLVNYLNTCGITSIIVSHDSGFLDNVTQYIIHYEGFKLRKYKGNLSEFVKKCPSAQSYYELGASDLEFRFPEPGFLEGVKTKQKAIVKVSNMSFQYPGTSKPQIQDINFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTTGEVYVHENCRIAYIKQHAFAHIDNHLDKTPSEYIQWRFQTGEDRETMDRASRQINEEDEQNMNKIFKIEGTPRRIAGIHARRKFKNSYEYEISWMLGENIGMKNERWVPMMSVDNTWLPRGELMETHAKLVAEVDMKEALASGQFRPLTRKEIEEHCAMLGLDAELVSHSRIRGLSGGQKVKLVLAACTWQRPHLIVLDEPTNYLDRDSLGALSKALKAFEGGIVIITHSAEFTKDLTEEVWAVLDGRMTPSGHNWVQGQGSGPRIEKKDDEEEDKFDAMGNKIAAAKKKKKLSSAELRKKKKERMKKKKELGDAYVSSDEEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>P83778</accession>
    <accession>A0A1D8PRT1</accession>
    <accession>Q5AAK8</accession>
    <name>MDHC_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Malate dehydrogenase, cytoplasmic</fullName>
            <ecNumber>1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MDH1</name>
        <name type="synonym">MDH2</name>
        <name type="ordered locus">CAALFM_CR00540CA</name>
        <name type="ORF">CaO19.7481</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proteomics" volume="4" first="3084" last="3106">
            <title>Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Abian J."/>
                <person name="Carrascal M."/>
                <person name="Sanchez M."/>
                <person name="Nombela C."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="15378761"/>
            <dbReference type="DOI" id="10.1002/pmic.200400903"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 27-36; 39-55; 95-104 AND 231-244</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ANTIGENICITY</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
            <tissue>Protoplast</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37"/>
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        <property type="protein sequence ID" value="AOW30823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CR_00540C_A-T-p1"/>
        <property type="gene ID" value="CR_00540C_A"/>
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    <dbReference type="GeneID" id="3639667"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00540CA"/>
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    <dbReference type="eggNOG" id="KOG1494">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="Malate dehydrogenase"/>
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        <property type="entry name" value="Malate dehydrogenase"/>
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        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
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        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
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        <property type="entry name" value="Lactate/malate_DH_C"/>
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    <dbReference type="InterPro" id="IPR001236">
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        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
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        <property type="entry name" value="Malate_DH_AS"/>
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        <property type="entry name" value="Malate_DH_type1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
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    </dbReference>
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        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_0000113337" description="Malate dehydrogenase, cytoplasmic">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="2">
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            <position position="184"/>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <ligand>
            <name>substrate</name>
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            <position position="92"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="122"/>
            <end position="124"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
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        <ligand>
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        <location>
            <position position="238"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>DE</original>
        <variation>TD</variation>
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            <begin position="28"/>
            <end position="29"/>
        </location>
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    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>FDVV</original>
        <variation>YDIR</variation>
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            <begin position="33"/>
            <end position="36"/>
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    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
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    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>L</original>
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            <position position="45"/>
        </location>
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    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>INSDSKTQ</original>
        <variation>VPTNSTVK</variation>
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            <begin position="48"/>
            <end position="55"/>
        </location>
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    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>I</original>
        <variation>T</variation>
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>Q</original>
        <variation>R</variation>
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>Y</original>
        <variation>Q</variation>
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>Y</original>
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        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P40926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15378761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="337" mass="36004" checksum="0BB466CAA0010CE4" modified="2011-10-19" version="2">MVKVAILGAAGGIGQPLSLLTKLNPNVDELALFDVVNVPGVGADLSHINSDSKTQSYLPKDKEDKTALAAALKGSDLVIIPAGVPRKPGMTRDDLFNINASIVQGLAEGIAANSPKAFVLVISNPVNSTVPIVAETLQAKGVYDPARLFGVTTLDIVRANTFISQLFLDQTKPSDFNINVVGGHSGETIVPLYSLGNSKQYYDILSEEQKKELIKRVQFGGDEVVQAKNGAGSATLSMAYAGYRLAESILAAVNGKTDIVECTFLNLDSSIKGASEARKLVKDLDFFSLPVQLGKNGITEVKYDILNQISDDEKKLLEVAIEQLQKNIEKGVSFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q59K96</accession>
    <name>Q59K96_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alk8p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">ALK8</name>
        <name evidence="12" type="ordered locus">CAALFM_CR07130CA</name>
        <name evidence="11" type="ordered locus">orf19.7683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710174.1">
        <property type="nucleotide sequence ID" value="XM_705082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59K96"/>
    <dbReference type="SMR" id="Q59K96"/>
    <dbReference type="STRING" id="237561.Q59K96"/>
    <dbReference type="GeneID" id="3648226"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07130CA"/>
    <dbReference type="CGD" id="CAL0000175837">
        <property type="gene designation" value="ALK8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07130C_A"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="Q59K96"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010430">
        <property type="term" value="P:fatty acid omega-oxidation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048252">
        <property type="term" value="P:lauric acid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000102">
        <property type="entry name" value="Cytochrome P450 52A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000175837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="515" mass="59332" checksum="58815AA87EF6CBED" modified="2005-04-26" version="1">MLEEISFESWYLYLIICGVLYFCTNYLYIQYLNKKLGAKSPGSCKSDGCFGFRSGFEMLKAKKIGRQVDLLHERFNDLSNPEVNDTFTSYNFGFPMIITKDPENIKALLATQFNDFSLGRRYDFFKPLLGKGIFTLDGEGWKHSRSMLRPQFAREQIAHVKALEPHFQLLKKHITKNKGQFFDIQELFFRFTVDSATEFLFGESVSSLKDESIGYNQDEFDFAGRKDFPEAFNKSQIYLSTRSLLQNLYWLVNPKDFQNCNAIVHKFSDYYVNKALNATPEELEKNSGYVFLYELVKQTRDPQVLRDQALNILLAGRDTTAGLLSFAVFELARNPQVWKKLREEIIERYADGATEISFETLKQCEYLKAVINETLRLYPSVPRNGRFANKNTTLPRGGGPDGMSPILIKQGQAVMYSIYSTQRDPKYYGKDADVFRPERWFEPETRKLGWAFLPFNGGPRICLGQQFALTEASYVLVRLAQCCENLQLTEGIEYPPAKLTHLTMCMFDGVPIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LU6</accession>
    <name>Q59LU6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Triglyceride lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR02570CA</name>
        <name evidence="2" type="ordered locus">orf19.7798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710701.1">
        <property type="nucleotide sequence ID" value="XM_705609.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LU6"/>
    <dbReference type="SMR" id="Q59LU6"/>
    <dbReference type="FunCoup" id="Q59LU6">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LU6"/>
    <dbReference type="GeneID" id="3647685"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02570CA"/>
    <dbReference type="CGD" id="CAL0000201637">
        <property type="gene designation" value="orf19.7798"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02570C_A"/>
    <dbReference type="HOGENOM" id="CLU_061432_0_0_1"/>
    <dbReference type="InParanoid" id="Q59LU6"/>
    <dbReference type="OMA" id="DQVTHGD"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="55"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="401" mass="45631" checksum="CD05DC14A51C36CC" modified="2005-04-26" version="1">MSFSVEKKTTLAHPFRAPGSTLISSDQSNLKIVYNKYKTRSPLPNSTNQLRYNFIFCHGTGFNKSIWKYHISKLYQLSQSLQVPWFLDSVIAIDMVGHGDSSLENQGKLGTIFRWDDGAKDVIAIIKHEIATTGDFQNNLESRNLIIGHSMGGFNSLYATFLEPSLFDAVIPIEAVIYGAPGGLEKFSKKFSKISKLLIDTFDSKDDINFFFKEFSFFKNMQDQVSDDFINDEVYEIKDKESGEIKYKLKCNTPHQMAAYYGAFMSIPFGMFAIPHIRVPICHVIGSKGVWNPPESITWIRGAINKEFLAGKVDVPKGEHLLNVELPDETIDIIQNFTTERTKAFIEARNNLPEVKLNNNKEAIAKEQFQNLIDLKFDQVNGYFIEDRVDNYEALQKLAKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MC8</accession>
    <accession>A0A1D8PDR8</accession>
    <name>MDM34_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM34</name>
        <name type="ordered locus">CAALFM_C106230CA</name>
        <name type="ORF">CaO19.1826</name>
        <name type="ORF">CaO19.9385</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710877.2">
        <property type="nucleotide sequence ID" value="XM_705785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MC8"/>
    <dbReference type="SMR" id="Q59MC8"/>
    <dbReference type="BioGRID" id="1230606">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59MC8">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MC8"/>
    <dbReference type="EnsemblFungi" id="C1_06230C_A-T">
        <property type="protein sequence ID" value="C1_06230C_A-T-p1"/>
        <property type="gene ID" value="C1_06230C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647517"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106230CA"/>
    <dbReference type="CGD" id="CAL0000184363">
        <property type="gene designation" value="MDM34"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06230C_A"/>
    <dbReference type="eggNOG" id="ENOG502QT3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476594_0_0_1"/>
    <dbReference type="InParanoid" id="Q59MC8"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="PRO" id="PR:Q59MC8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384333" description="Mitochondrial distribution and morphology protein 34">
        <location>
            <begin position="1"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="623" mass="70239" checksum="699AAAEA6DD3FD24" modified="2017-03-15" version="2">MSFKVNWNSLETEPLTNWTKELLTSALNSGKSPNILALNITIKDLNFGKIAPDFEILEIGELDRDRFRGIFKIDYQGDFHLTLHTKVQANPLNIYYHNSLEKEVCNYSQDEFITPNFLLSNEQFAIPLDLKLSDIKINGIGIIVFSKSKGLTLVFRNDPLDSIKVSSTFDTVQVLANFLQKQIENQIRDLFRETLPTLIHQLSLKYLSLDNNINEIKSKLSQQDSVSMTNNELASSLKLFDDEENEFPLIYSSKNLQKNMQLFKSRETFRLSAPKFKNIVQRTRLDKFTKSYPNLLNSLYANNADLQHRFVNNINHGHNNNSNTSSTGIPIELLVSHDDKQHYGKTDNLLKDISSIQANNFYKYSNKDAPNKPKRRRIKVHKKSKVKQDDNTVKASELQNVDSTFMESRSISPQETIDTTSTLIESAPMTRNVSTNIKSPTLETMSTGSSSSASSQVIAHPTPKRAHQPADSTVSTTTINKENHIDYIKARNLYQDFIQMSQSPGYYDKVISNGRGIGLGNSGGNYFGFNGNGNGLERTMSASPIKHLNKDKKSINYIDTSKINEKLNQFRLDGGKNSANTNNSSGGKNFRPGFTRNESNGQQGILFEAFNFPSVAPPPPPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q59N83</accession>
    <name>Q59N83_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C503910CA</name>
        <name evidence="1" type="ordered locus">orf19.8701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711157.1">
        <property type="nucleotide sequence ID" value="XM_706065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59N83"/>
    <dbReference type="GeneID" id="3647221"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503910CA"/>
    <dbReference type="CGD" id="CAL0000180290">
        <property type="gene designation" value="orf19.8701"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03910C_A"/>
    <dbReference type="eggNOG" id="ENOG502T4X9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677620_0_0_1"/>
    <dbReference type="InParanoid" id="Q59N83"/>
    <dbReference type="OrthoDB" id="4024815at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000180290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="157" mass="18367" checksum="28584AFB8AC09E1C" modified="2005-04-26" version="1">MNDNFNSSNFSSFKNSPTLLTSTNEQLNRLWNLILKFDRISITSTDINIEDTDNNSSTGDDQFISIEKFYKLLINYHKLIELITIKNNELTIMKFQCFEIIRNIQQQQQQQKPNTHKMFNQHNSTATYSSSSFSSFNETGKKLQDIFNPKEEFDSTI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P03</accession>
    <accession>A0A1D8PMC6</accession>
    <name>NCB5R_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>NADH-cytochrome b5 reductase 1</fullName>
            <ecNumber evidence="2">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Microsomal cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CBR1</name>
        <name type="ordered locus">CAALFM_C405450CA</name>
        <name type="ORF">CaO19.1801</name>
        <name type="ORF">CaO19.9367</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711449.1">
        <property type="nucleotide sequence ID" value="XM_706357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P03"/>
    <dbReference type="SMR" id="Q59P03"/>
    <dbReference type="BioGRID" id="1230038">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59P03">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59P03"/>
    <dbReference type="EnsemblFungi" id="C4_05450C_A-T">
        <property type="protein sequence ID" value="C4_05450C_A-T-p1"/>
        <property type="gene ID" value="C4_05450C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646961"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405450CA"/>
    <dbReference type="CGD" id="CAL0000182794">
        <property type="gene designation" value="CBR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05450C_A"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="InParanoid" id="Q59P03"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="PRO" id="PR:Q59P03"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000330148" description="NADH-cytochrome b5 reductase 1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="294" mass="32472" checksum="EC4D6DB09B6733B4" modified="2005-04-26" version="1">MSETTTVPPIETVSEPNPFIVFATVATIISAFIGYYFLQQSKKHTPVLKPDEFQKFPLIEKIRVSHNSAIYRFGLPKSTDRLGLPIGQHISIGATIDGKEVVRSYTPISTDDQLGHFDLLIKTYENGNISRHVAGKNVGEHIEIRGPKGFFTYTPNMVKSFGMIAGGTGIAPMYQIITAILKNPEDKTKIHLVYANVTESDILLKEELDNFAARHPDRLKIHYVLNEAPANWQGSVGFVTPEIIDTHLPKASNDTNLLLCGPPPMVSAMKKAAVELGFQKAKPVSKLGDQVFVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2025-06-18" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P11</accession>
    <accession>A0A1D8PMA8</accession>
    <name>HSV2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>SVP1-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSV2</name>
        <name type="ordered locus">CAALFM_C405350WA</name>
        <name type="ORF">CaO19.1793</name>
        <name type="ORF">CaO19.9359</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Vesicular and vacuolar.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711441.1">
        <property type="nucleotide sequence ID" value="XM_706349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P11"/>
    <dbReference type="SMR" id="Q59P11"/>
    <dbReference type="FunCoup" id="Q59P11">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59P11"/>
    <dbReference type="EnsemblFungi" id="C4_05350W_A-T">
        <property type="protein sequence ID" value="C4_05350W_A-T-p1"/>
        <property type="gene ID" value="C4_05350W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646948"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405350WA"/>
    <dbReference type="CGD" id="CAL0000194175">
        <property type="gene designation" value="orf19.9359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05350W_A"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_0_1_1"/>
    <dbReference type="InParanoid" id="Q59P11"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="PRO" id="PR:Q59P11"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000051025" description="SVP1-like protein 2">
        <location>
            <begin position="1"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="595" mass="64279" checksum="C7A833CF32C322CA" modified="2005-04-26" version="1">MVLAHSINTNPNTNTNTNNTSTTSSTTTIPNDSKILCINFNQDQGCFAISHEQGFLVYNTDPIELRVKRNFIVNSHTTSSRSNHSNGSNSNNNHRNNSTGSNGSVSSSGSNNETTLGYKSTHKSASGSGSGSGSGIGHISMLHRTNYLALIGGGENPKFPINKLIIWDDLKRKTSLSLEFDTPVLNVLLSRVRIIVVLIDQIIVYGFAAPPKKFQTFNTINNPLGIADLSVNSQQSNVHLYNNYSSNSAQAQVSGTTTTTHYDFSKRKSLSPTNSSNSSSTSLKENGTNLTTYPSPSSTTSASASVATITNTPEAATTANPTTATTTATTTATTTTTTTSAKPLVNGIGSSYQTLAFPGRSMGQIQIVDVGNNHHSGTNIKPTINIIKAHKSNIRCLCLNRTGTLIASASITGTIIRIHSTRTTALLYEFRRGIDRAIITSMKFSHDDSKLAVLSDKHTLHVYNIDETQYPNDGGSGGTKDGGGGGRGSKNRHHLLNGLLPYLPNYFQSTWSFCSVNTNKYHTSDLEDNSQQQQQQWVANGTGGGGVDEGVIGWSGNDSIIIIWKLKKIWEKYVIVETENHQYDLIRSSWKRLDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P50</accession>
    <accession>A0A1D8PHM3</accession>
    <name>YSH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Endoribonuclease YSH1</fullName>
            <ecNumber>3.1.27.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">YSH1</name>
        <name type="ordered locus">CAALFM_C206230WA</name>
        <name type="ORF">CaO19.12941</name>
        <name type="ORF">CaO19.5486</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.27.-"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711478.1">
        <property type="nucleotide sequence ID" value="XM_706386.1"/>
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    <dbReference type="AlphaFoldDB" id="Q59P50"/>
    <dbReference type="SMR" id="Q59P50"/>
    <dbReference type="FunCoup" id="Q59P50">
        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59P50"/>
    <dbReference type="EnsemblFungi" id="C2_06230W_A-T">
        <property type="protein sequence ID" value="C2_06230W_A-T-p1"/>
        <property type="gene ID" value="C2_06230W_A"/>
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    <dbReference type="GeneID" id="3646911"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206230WA"/>
    <dbReference type="CGD" id="CAL0000178545">
        <property type="gene designation" value="orf19.12941"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06230W_A"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="InParanoid" id="Q59P50"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:termination of RNA polymerase II transcription"/>
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    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
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    </dbReference>
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        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000238898" description="Endoribonuclease YSH1">
        <location>
            <begin position="1"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="870" mass="97899" checksum="D403C2942B7B87B7" modified="2005-04-26" version="1">MCIQPDSLEDAYKIPRPVHREEFTQLSPSFFQTATFQLEKTNEKNNIEEPKKNKAFLNSKIIYKDLFEIRKLSNNFVNTSHPTCTETMNEQNEFSDEENFKFFGLGGCNEVGRSCHIIEYKNKVIMLDSGMHPALSGHASFPYFDEYDISKVDILLISHFHVDHSASLPYVMQQSNFRGKVFMTHATKAIYRWLMQDFVRVTSIGNSRSEDGGGGEGSNLYTDDDIMKSFDRIETIDYHSTMEIDGIRFTAYHAGHVLGACMYFIEIGGLKVLFTGDYSREENRHLHAAEVPPLKPDILISESTFGTGTLEPRIELERKLTTHIHATIAKGGRVLLPVFALGNAQELLLILDEYWSQNEDLQNVNVFYASNLAKKCMAVYETYTGIMNDKIRLSSASSEKSNPFDFKYIKSIKDLSKFQDMGPSVVVATPGMLQAGVSRQLLEKWAPDGKNLVILTGYSVEGTMAKELLKEPTMIQSATNPDMTIPRRIGIEEISFAAHVDFQQNSEFIEKVSPSKVILVHGDSVPMGRLKSALLSKYASRKGTDQEVKVYNPKNCEELIIGFKGLKIAKVLGSLAEEQLQVLKKIIQDEVSAENSKITELTEEKEEADEIKEDNGETDTTQKPNESSINVLKTGQVVSGVLVSKDFNLNLLQLQDLHEFTQLSTSIVKSKMHLKINADISLMVWHLEQMFGYINVINDDDEEWECVIMDVVDVFIDRSKGPGLFITVEWINDNLMADSLADSVIAILYSIDSSPASVKLSSQNHNHGDNHIVKKEDSMEIDRPVEAHAKTDIKSRIERIALLLKAQFGDSLKELPEEKAIIQIGKTVANVDYKRLEVECSSKVLKDRVENVIKRGCQLTAPLSQNPKIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PD3</accession>
    <accession>A0A1D8PFG2</accession>
    <name>CWC15_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CWC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CWC15</name>
        <name type="ordered locus">CAALFM_C112630CA</name>
        <name type="ORF">CaO19.13717</name>
        <name type="ORF">CaO19.6360</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711578.1">
        <property type="nucleotide sequence ID" value="XM_706486.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PD3"/>
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        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PD3"/>
    <dbReference type="EnsemblFungi" id="C1_12630C_A-T">
        <property type="protein sequence ID" value="C1_12630C_A-T-p1"/>
        <property type="gene ID" value="C1_12630C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646838"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112630CA"/>
    <dbReference type="CGD" id="CAL0000187979">
        <property type="gene designation" value="orf19.13717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12630C_A"/>
    <dbReference type="eggNOG" id="KOG3228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068312_1_0_1"/>
    <dbReference type="InParanoid" id="Q59PD3"/>
    <dbReference type="OMA" id="KYREHGQ"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="PRO" id="PR:Q59PD3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-1185">Reference proteome</keyword>
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            <end position="224"/>
        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <begin position="158"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="224" mass="25987" checksum="B4EB8FA61BCE5D0F" modified="2005-04-26" version="1">MSTNHRPQLESKRGKVIKIKDTIQHARGLPQQTSIKYRQDIKNEKTINKFDDLQKHDNNKITSLESISPPTKKLKIESTKEITTEPLNQEIDKQSKLSLKNDDQSDIQPNEKSESDEEDSKDEEDDESSDDDDSDDDDTALLLKEIENIRREKEKQNSDSTNNSINNSLTLQTHDSSTKKKSWRSSTTFNNKSKKESTNDRNNNYTTDTLNSQHHQKFMSKYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Bub3p</fullName>
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        <name evidence="5 6" type="primary">BUB3</name>
        <name evidence="6" type="ordered locus">CAALFM_C503240WA</name>
        <name evidence="5" type="ordered locus">orf19.10178</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712037.1">
        <property type="nucleotide sequence ID" value="XM_706944.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q59QR8">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q59QR8"/>
    <dbReference type="GeneID" id="3646362"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503240WA"/>
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    <dbReference type="eggNOG" id="KOG1036">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="373" mass="42875" checksum="C15290AB695DCF5F" modified="2005-04-26" version="1">MTTPFVELQTPKNLDIISDVCFMDNTDQHRLLVSNWNSEILLFSCDSLLHEHQPPHLQPINTFTTPDIPLCLLYDNKQNVSPLVGLLDGSIRELDFENGKLGDNIGDAVDDNNEIDSGINNLKNVNISGQNSSSIVASSFNGKLQLIDTRQSQRQQQKLSPQTFHNQRKIFTMDTSDQYLILGLQNNIIEIYDFKNLHHPLETRQVGLKYQIKDLKTFPDNQGFALSTIDGRVSMEYFNPDPQFQLQNRFTFKCHRHPDPNPESAGDLVYPVNSLDFNHKYGTLFTAGSDGYVCLWDCKKRKRMRQYPRFLSAENEPESIVKLKINRQDNLMVVATSDDNYKRRRRLSESENSKTPSRVYVKQLAENECKPKS</sequence>
</entry>
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    <accession>Q3MNZ9</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">CAALFM_C703580CA</name>
        <name evidence="2" type="ordered locus">orf19.13982</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Candida</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712143.1">
        <property type="nucleotide sequence ID" value="XM_707050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59R30"/>
    <dbReference type="STRING" id="237561.Q59R30"/>
    <dbReference type="GeneID" id="3646238"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703580CA"/>
    <dbReference type="CGD" id="CAL0000201958">
        <property type="gene designation" value="orf19.13982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03580C_A"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="InParanoid" id="Q59R30"/>
    <dbReference type="OrthoDB" id="4021105at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="692" mass="79612" checksum="B1BCED60FAA009B9" modified="2005-04-26" version="1">MTIVTTDVDFFRDISKLPSEIIVIIIGYLPKCMLPQLLYFQPIQKEVAFIILLDVNITERKRHKGSETPHVGYSECDCNRFKIELNNLKKGIAQWNVYPRAIHMDDKFVFRDVLDTFPRLLKETSSINGTLSQCEGIKAEALLNLFFNTNLRFDSMQLNGLWDPATLPSVATSIRLFHTTLNSYVIPGVKKLDMEMYSNTRESQTYTFSPDLEDLRIDFNFTIQVTLPPNLQKLCITTSLDSANFVSPELVRLEYLQLQLKNIQSFDETGIIAPNLKILDLTGCFKMSNFNGLKQFQRLKRLRLKYCVYPVGLFEECSFNELESFEYIGKGFPVSCDVSCSRLTIPSNLKSLSIKNIGNMNVDLRTLVFPAKLTRLELVDLSFNDGYFHLGENLQYVHIETSTLRFDSSFKIPHLAGELILEADYLSFDSPEFMYHLPNSLTRLQLIANKQGKMGPFIRKIKWPLVLGDFAFKNFSIDYHTLELLNLKESRLEVIYIRGGNIKKLNVDLFPVSVKNLTLMEMGIHELPASFKRLNNLRQLSLMGNQLRNVNSVKLPVLSLEVLNVRQCNLRLISPFLVSMLEEKNQNANLRVEATGNLNVNIIDVRKVLKAIKGLSLELNRLNDSLLKISNHSYRLEAVYRDFDPYFEKSKSSENEEVVSDYDSDDLYNGSVFYSDEEYSDDEDDNNKRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RK3</accession>
    <name>Q59RK3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C600390WA</name>
        <name evidence="12" type="ordered locus">orf19.8792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
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            <taxon>Saccharomycotina</taxon>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="22"/>
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            <end position="127"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000183962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="127" mass="14784" checksum="36091822D45C5E62" modified="2005-04-26" version="1">MGRIHGFLGGVLLTSSLAYSTSQYINKNQQFISQNLRQSDYIINNRILSDADAKLRENYVPDSHVKYQSRVNFAETCKDIWNEEIITMVNWVYSLNWYKMGLDIDAKVNQWTDRIAESVAKKAEEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T44</accession>
    <name>RS8A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS8A</name>
        <name type="ordered locus">orf19.6873</name>
        <name type="ORF">CAALFM_C205610CA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712803.1">
        <property type="nucleotide sequence ID" value="XM_707710.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="J=1-206"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="J=1-206"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="J=1-206"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="J=1-206"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="J=1-206"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CV/K=1-206"/>
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    <dbReference type="PDB" id="8OGJ">
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        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="CV/K=1-206"/>
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    <dbReference type="PDB" id="8OI5">
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        <property type="resolution" value="2.90 A"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="J=1-206"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
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    <dbReference type="PDBsum" id="8C3A"/>
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    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="Q59T44"/>
    <dbReference type="EMDB" id="EMD-13737"/>
    <dbReference type="EMDB" id="EMD-13741"/>
    <dbReference type="EMDB" id="EMD-13744"/>
    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="Q59T44"/>
    <dbReference type="FunCoup" id="Q59T44">
        <property type="interactions" value="1201"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59T44"/>
    <dbReference type="EnsemblFungi" id="C2_05610C_A-T">
        <property type="protein sequence ID" value="C2_05610C_A-T-p1"/>
        <property type="gene ID" value="C2_05610C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645565"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205610CA"/>
    <dbReference type="CGD" id="CAL0000186765">
        <property type="gene designation" value="RPS8A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05610C_A"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="InParanoid" id="Q59T44"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456546" description="Small ribosomal subunit protein eS8">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="206" mass="22753" checksum="AF437FECA4742FDB" modified="2005-04-26" version="1">MGISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGPKRIHSVRTRGGNQKFRALRVETGNFSWGSEGVSRKTRIAGVVYHPSNNELVRTNTLTKSAVVQIDATPFRQWYENHYGATLGKKKGGAHAAHAAEVADAKRSRKVERKLAARSGAAAIESAVDSQFGSGRLYAVISSRPGQSGRCDGYILEGEELAFYLRRLTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UI3</accession>
    <name>Q59UI3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR03410WA</name>
        <name evidence="2" type="ordered locus">orf19.9917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713214.1">
        <property type="nucleotide sequence ID" value="XM_708121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UI3"/>
    <dbReference type="GeneID" id="3645136"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03410WA"/>
    <dbReference type="CGD" id="CAL0000192404">
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    <dbReference type="OMA" id="SINKSEC"/>
    <dbReference type="OrthoDB" id="4080041at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="312" mass="36790" checksum="C88D23415D093E33" modified="2005-04-26" version="1">MSSVRKIAAYLERKEDLSQEYNSLKEVFKDEPDYEGLANVFEILKFLDQLIYEYHVHKSYLQCTKGPINDFERKLLAEMEKTIKQLEDDVSLPYLIENAQNLALIRRELFENAHEGGRLIHAYELQNPSSKMMIRSSQPSRPFTTLSDQLHSSKSTPSHSKSPLQLSSNVSEHHALIQSPKEMRNLARAMTWSKRCTDIVFEAGKLDANLTQKYQYISSHIEDEFGYQFCRDFSRYLYLHYIEGDAAKFREDFDKAYIKYLDFSTQKVSELIEKDLKINRKVCRYGIWLREIFQRTYGKITEPPENFLYTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UP4</accession>
    <name>Q59UP4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C400470CA</name>
        <name evidence="10" type="ordered locus">orf19.13121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713357.1">
        <property type="nucleotide sequence ID" value="XM_708264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UP4"/>
    <dbReference type="FunCoup" id="Q59UP4">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="GeneID" id="3645011"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400470CA"/>
    <dbReference type="CGD" id="CAL0000197496">
        <property type="gene designation" value="orf19.13121"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00470C_A"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011811_0_0_1"/>
    <dbReference type="InParanoid" id="Q59UP4"/>
    <dbReference type="OMA" id="PRWKKCP"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="MAG2p Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000197496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="603" mass="69760" checksum="5B0D4A39C0889F44" modified="2005-04-26" version="1">MANSTSNPAIIMAKDDNSVSGQHKQSSQNHRSKQTNKNQKRQNRQSRYDHSNDHELNIIESQLKNGKKVKGSKNQISINHLLEFQSYRDSEEYRSNQQRNRRRRSSSHKRPYSHNKIQLTGMRFINVNFKFVVDGRKDYRVQELDPNVPVDTDDIIRIIAPRGNSCPICLTDDFVAPRMITSCGHIICLKCVLSLLGNEVPQAKKRESAAIVEKYRECPLCFSIIRKHELKPVLMNNVDERFEVPKVGDEVVMTLMARPMDQILALPKLLAFDSHIRGFPDTKQFELLPYSRIFRGDSQYILEMYEEEKRDIMAAYEEEKLVYGDDSSLVAESIAYIDKEVEQWNNKLLQNVVKEPNPSHTTDNSHSIYYFYETGFNAGCTYVLSPLDMKVLKTTYNDYATLPSSLVAQIENIRYEELTAETSMNRYKYLSHLPLGSEIGFLECDWSNSEFTSTETWEIFKDDLLKRSNNSKRKLRKEERDKKRAMNEEETRTRNFFLHENGEAEIEQGYSTLGFGSLSIVDNRDLPALSDQHVSTESEKEYETTVWGTRIPKNEAVSSQSAIEDDDWEAEEMIRKAKEEMSRQEQAGGGKKKKKKKLVLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q59US8</accession>
    <name>Q59US8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Damage-regulated import facilitator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C400170WA</name>
        <name evidence="7" type="ordered locus">orf19.13087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713323.1">
        <property type="nucleotide sequence ID" value="XM_708230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59US8"/>
    <dbReference type="STRING" id="237561.Q59US8"/>
    <dbReference type="GeneID" id="3645028"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400170WA"/>
    <dbReference type="CGD" id="CAL0000201863">
        <property type="gene designation" value="orf19.13087"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00170W_A"/>
    <dbReference type="eggNOG" id="ENOG502SG7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132208_0_0_1"/>
    <dbReference type="InParanoid" id="Q59US8"/>
    <dbReference type="OMA" id="SNVSEWG"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000201863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="137" mass="15682" checksum="8C482ED950029D98" modified="2005-04-26" version="1">MMQPRVKRHMQNAIQPVENLNEDAASLPSVAMRIRKAVSEGYKLPGDNTASQQFSGNFQRVPLPSSMTGPPDLVNGQSTRTVSNLEEWDSYYKIQNAPLQTLPESNNYLKRKFEDDHELDLSQYQAKYGELKFNEEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VG6</accession>
    <name>ERG3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Delta(7)-sterol 5(6)-desaturase ERG3</fullName>
            <ecNumber evidence="9">1.14.19.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">C-5 sterol desaturase ERG3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ergosterol Delta(5,6) desaturase erg3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ergosterol biosynthesis protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sterol-C5-desaturase ERG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ERG3</name>
        <name type="ordered locus">orf19.767</name>
        <name type="ORF">CAALFM_C104770CA</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1997" name="FEBS Lett." volume="400" first="80" last="82">
            <title>Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation.</title>
            <authorList>
                <person name="Kelly S.L."/>
                <person name="Lamb D.C."/>
                <person name="Kelly D.E."/>
                <person name="Manning N.J."/>
                <person name="Loeffler J."/>
                <person name="Hebart H."/>
                <person name="Schumacher U."/>
                <person name="Einsele H."/>
            </authorList>
            <dbReference type="PubMed" id="9000517"/>
            <dbReference type="DOI" id="10.1016/s0014-5793(96)01360-9"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AZOLE-RESISTANCE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Gene" volume="236" first="43" last="51">
            <title>Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans.</title>
            <authorList>
                <person name="Miyazaki Y."/>
                <person name="Geber A."/>
                <person name="Miyazaki H."/>
                <person name="Falconer D."/>
                <person name="Parkinson T."/>
                <person name="Hitchcock C."/>
                <person name="Grimberg B."/>
                <person name="Nyswaner K."/>
                <person name="Bennett J.E."/>
            </authorList>
            <dbReference type="PubMed" id="10433965"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(99)00263-2"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="Antimicrob. Agents Chemother." volume="54" first="4527" last="4533">
            <title>Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.</title>
            <authorList>
                <person name="Martel C.M."/>
                <person name="Parker J.E."/>
                <person name="Bader O."/>
                <person name="Weig M."/>
                <person name="Gross U."/>
                <person name="Warrilow A.G."/>
                <person name="Rolley N."/>
                <person name="Kelly D.E."/>
                <person name="Kelly S.L."/>
            </authorList>
            <dbReference type="PubMed" id="20733039"/>
            <dbReference type="DOI" id="10.1128/aac.00348-10"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>VARIANTS GLU-97; GLY-147; PRO-193; ALA-237; ASN-243; ALA-330; VAL-351 AND THR-353</scope>
        <scope>AZOLE-RESISTANCE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 6 8">C-5 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathwa (PubMed:10433965, PubMed:20733039, PubMed:9000517). ERG3 catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol (PubMed:10433965). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:54320"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:138130"/>
            <dbReference type="ChEBI" id="CHEBI:138131"/>
            <dbReference type="EC" id="1.14.19.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54321"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is repressed during spider biofilm formation (PubMed:22265407).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The histidine box domains may contain the active site and/or be involved in metal ion binding.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4 6">Defects in C-5 sterol desaturation results in antibiotic and azole resistance of Candida albicans during infection, particularly in AIDS patients.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.20" evidence="9"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713577.1">
        <property type="nucleotide sequence ID" value="XM_708484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VG6"/>
    <dbReference type="FunCoup" id="Q59VG6">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VG6"/>
    <dbReference type="EnsemblFungi" id="C1_04770C_A-T">
        <property type="protein sequence ID" value="C1_04770C_A-T-p1"/>
        <property type="gene ID" value="C1_04770C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644776"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104770CA"/>
    <dbReference type="CGD" id="CAL0000190948">
        <property type="gene designation" value="ERG3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04770C_A"/>
    <dbReference type="eggNOG" id="KOG0872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_3_0_1"/>
    <dbReference type="InParanoid" id="Q59VG6"/>
    <dbReference type="OMA" id="GPGLWYN"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="BRENDA" id="1.14.19.20">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00768">
        <property type="reaction ID" value="UER00762"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:11044"/>
    <dbReference type="PHI-base" id="PHI:8029"/>
    <dbReference type="PHI-base" id="PHI:8122"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000248">
        <property type="term" value="F:C-5 sterol desaturase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050046">
        <property type="term" value="F:delta7-sterol 5(6)-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000454172" description="Delta(7)-sterol 5(6)-desaturase ERG3">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-2" evidence="1">
        <location>
            <begin position="239"/>
            <end position="243"/>
        </location>
    </feature>
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            <begin position="314"/>
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    <feature type="sequence variant" description="In strain: azole-resistant isolates." evidence="4">
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            <position position="97"/>
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    <feature type="sequence variant" description="In strain: azole-resistant isolates." evidence="4">
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            <position position="147"/>
        </location>
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        </location>
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        <original>V</original>
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        <location>
            <position position="237"/>
        </location>
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    <feature type="sequence variant" description="In strain: azole-resistant isolates." evidence="4">
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            <position position="243"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: azole-resistant isolates." evidence="4">
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        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: azole-resistant isolates." evidence="4">
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        <location>
            <position position="351"/>
        </location>
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    <feature type="sequence variant" description="In strain: azole-resistant isolates." evidence="4">
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            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53045"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10433965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="20733039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="9000517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="10433965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="10433965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="386" mass="45419" checksum="E5CF1DA5EAFCF83B" modified="2005-04-26" version="1">MDIVLEICDYYLFDKVYADVFPKDGAVHEFLKPAIQSFSQIDFPSLPNLDSFDTNSTLISSNNFNISNVNPATIPSYLFSKIASYQDKSEIYGLAPKFFPATDFINTSFLARSNIFRETLSLFIITTIFGWLLYFIVAYLSYVFVFDKKIFNHPRYLKNQMSLEIKRATTAIPVMVLLTIPFFLLELNGYSFLYLDINECTGGYKAILWQIPKFILFTDCGIYFLHRWLHWPSVYKVLHKPHHKWIVCTPFASHAFHPVDGFFQSLPYHLYPLLFPLHKVLYLFLFTFVNFWTVMIHDGSYWSNDPVVNGTACHTVHHLYFNYNYGQFTTLWDRLGNSYRRPDDSLFVKDAKAEEEKKIWKEQTRKMEEIRGEVEGKVDDREYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="5" type="ordered locus">CAALFM_C600940CA</name>
        <name evidence="4" type="ordered locus">orf19.7741</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30040.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000559">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRM"/>
    </dbReference>
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        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012994623" evidence="3">
        <location>
            <begin position="16"/>
            <end position="296"/>
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    </feature>
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        <location>
            <begin position="79"/>
            <end position="98"/>
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    </feature>
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            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000193527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="296" mass="32573" checksum="3618E9C6884D5217" modified="2005-04-26" version="1">MITAILLLIAKQVTGVELHHHHKHASNITTLSITPTLVARDATEDAMPTLSTGEPTLSITHIPVSKNPYIYSSNLPSNLVFIVIGAILGAILLSIILYRITAHFKYNRQAMNEKETYYTNLTEILNQKGTPYSRNSSILDLSNSNNNTTDLSSSSTSSNQGRSYRDSVLGNNKPMMTNKPSRNSMFISPTMDLKTFELPLYQKQHSTSSASLILRYNNDSSTIVSTAFDEKSRITTTSTTVDGNESSINGSTINGSYLENGKLAPPPPKRVVRAPSLYLEDLLNDKSKDDKEEEGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-04-09" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZU1</accession>
    <accession>A0A1D8PFY9</accession>
    <name>YPI2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Type 1 phosphatases regulator YPI2</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name type="ordered locus">CAALFM_C114350WA</name>
        <name type="ORF">CaO19.7250</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPI1 family.</text>
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        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
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    <dbReference type="InterPro" id="IPR011107">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="147" mass="16840" checksum="3635D0385CCFCB93" modified="2005-04-26" version="1">MSNQPSRTIVQENNVLRLRPGSEPTPSSSNQQPPQQEQQQETTSTKKKKKKKAPKVRWTEGTVDNEHMNKKKTKICCIFHPQRSFDEEVEDDKHNHSCSSSDESSDSSDNEGDKDEDESRPSNGIPKPNAYEYQPHYENRSKLPEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4K9</accession>
    <name>Q5A4K9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </dbReference>
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    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <source>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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                <person name="Weissman J.S."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037327">
        <property type="entry name" value="TFIIIB_Bdp1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="502"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
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            <begin position="47"/>
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            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
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            <end position="187"/>
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            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000190298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="662" mass="74064" checksum="9739AAF87B7C88B4" modified="2005-04-26" version="1">MSSLVKKGGTSFTPKLKKVVRKKPVTAAKPPATPPATQVKEGDDDTSTVIFDTKNTSGVLAAGIETSTADVETSIATPASTQLPDSPKSKPAFRIGLTKTSSSDKSQKDNDIDPKDSSKQYANENENENENAIASSSEEDDDEDIFKPPVDPSKSRRQSITQRRLSNITASGLRSRSASISLHTADSNHVPAKIGIPVSKPTKRRRSSAQARSSKRVSTTQPAKPKAVVVPTVSTEPTSSSMDKSESSTREEKKPPKKSDIKGISDDFIVGIDPKTQKLTKFRRKGATKVKKESDSVKTENESVKPEGDEVKVEVLSDTDSIPEEPDNLITTVTHIHQIPKNINDEDADLFGEVDIDLEEVTMADLCKPTLRIGKVSTNFELVREAEQQLKQKKAQRRRDRELARLEGISLEDAIQKNEEQRRGNGDDVEKQDEEPKPDSLFDEEPQQAATSLQLTFTDGKIGFNEESAIVAKPRADITSRSVEKSNPFANPITSTTYSRRVFTDKWTSQELNQFYQALSMFGTDFSLISQLFPHRSRKQIKSKFNLEERRFPEVVELALRRKLPVDFEEYCANTKNDIKSLEYYNEELRKVRIEHEQSMNAIALEREKALKEDAEASRRREIEIRTGSKPMSRAEKLKELRKNETVVGSIDDVRKKRETNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABD2</accession>
    <name>Q5ABD2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uga32p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">UGA32</name>
        <name evidence="6" type="ordered locus">CAALFM_C100670CA</name>
        <name evidence="5" type="ordered locus">orf19.13459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719000.1">
        <property type="nucleotide sequence ID" value="XM_713907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABD2"/>
    <dbReference type="SMR" id="Q5ABD2"/>
    <dbReference type="GeneID" id="3639333"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100670CA"/>
    <dbReference type="CGD" id="CAL0000195594">
        <property type="gene designation" value="UGA32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00670C_A"/>
    <dbReference type="eggNOG" id="ENOG502SMTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_1_2_1"/>
    <dbReference type="InParanoid" id="Q5ABD2"/>
    <dbReference type="OMA" id="FQGCIQP"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000195594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW25765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="583" mass="66846" checksum="FF98AE913F1851ED" modified="2005-04-26" version="1">MFYVFDLTSNETIATDTSQAHELQPTTTPSNQQHIKLRTILNTSKRSRTGCLQCRARKKKCNEEHPVCGSCKRRKVNCSWRVTSKFKILKNGHQENSTSSEEIQESNYTRVDNQSTNDDPPDQNILRGSDKALHQKSDNTDIISLDKNLSSISPKYLSEPGYDFSDLSFLEHCIPSPINSHIFQPFKYLNVQGLYFLDGFIANVAKKFSIGHESSNYILKTFYQLSEEHEAVSYALAAWGGIFIEGGFTENVNHFLGEAIFKMSQEYPNLNNISKKDVYILLNYYLVYIGLQVCAGDVSQWHQIFHRTIDLVKRQGGLSSIIEMFDCSNEIKWLLSDIQYHDILSSNTFQKGTMLPMEEYNSVFKEAKILELGNYGLDPFQGCIQPIYLVLGEITSSAVDLRLRQHEIEIDGDITSRLEFYHEADKCYRDLSYKISNCIPNIEQMKLIKDDRYELELHLTLFEVYSLTCQLCLNYLIKKLPANTLDMQLLVLNCLASIDILIDTKMKSALSFSLLVCGITCCSKNDRSSMLNRFKIVSDDYKAGNVTLIKSIVEKVWERNQNGQLCVDWLTICQENNWNISFC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2025-06-18" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABG1</accession>
    <accession>A0A1D8PCE5</accession>
    <name>SET1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="1">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>COMPASS component SET1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SET1</name>
        <name type="ordered locus">CAALFM_C100960CA</name>
        <name type="ORF">CaO19.13430</name>
        <name type="ORF">CaO19.6009</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="60" first="697" last="709">
            <title>Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis.</title>
            <authorList>
                <person name="Raman S.B."/>
                <person name="Nguyen M.H."/>
                <person name="Zhang Z."/>
                <person name="Cheng S."/>
                <person name="Jia H.Y."/>
                <person name="Weisner N."/>
                <person name="Iczkowski K."/>
                <person name="Clancy C.J."/>
            </authorList>
            <dbReference type="PubMed" id="16629671"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05121.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3 (PubMed:16629671). Binds RNAs which might negatively affect its histone methyltransferase activity (By similarity). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (By similarity). Plays a role in the pathogenesis of invasive candidiasis (PubMed:16629671).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class V-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718971.1">
        <property type="nucleotide sequence ID" value="XM_713878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABG1"/>
    <dbReference type="SMR" id="Q5ABG1"/>
    <dbReference type="ELM" id="Q5ABG1"/>
    <dbReference type="FunCoup" id="Q5ABG1">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABG1"/>
    <dbReference type="EnsemblFungi" id="C1_00960C_A-T">
        <property type="protein sequence ID" value="C1_00960C_A-T-p1"/>
        <property type="gene ID" value="C1_00960C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639280"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100960CA"/>
    <dbReference type="CGD" id="CAL0000198993">
        <property type="gene designation" value="SET1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00960C_A"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004391_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ABG1"/>
    <dbReference type="OMA" id="ERLPCLC"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="PHI-base" id="PHI:11771"/>
    <dbReference type="PHI-base" id="PHI:2825"/>
    <dbReference type="PRO" id="PR:Q5ABG1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048869">
        <property type="term" value="P:cellular developmental process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905088">
        <property type="term" value="P:positive regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903341">
        <property type="term" value="P:regulation of meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055092">
        <property type="term" value="P:sterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12302">
        <property type="entry name" value="RRM_scSet1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000056">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-4 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000269767" description="Histone-lysine N-methyltransferase, H3 lysine-4 specific">
        <location>
            <begin position="1"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="898"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="591"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RxxxRR motif" evidence="1">
        <location>
            <begin position="867"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1014"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16629671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1040" mass="119161" checksum="30A4796C4C7B0160" modified="2005-04-26" version="1">MSYNNRSGGGASGGYSRRGYHGSHRGGYRTGRSKYPEDRYLVGGMLSLNKGSHYESSDNRYIPNEIGSKSPENRSHRSSTKDGRTPSGLSTPLSSSDKVSTPISIESINGSDRNTGVNNKDSEFPKLSHHSDFTSTIPFSRSINPQKNFMVINDSHTPKTDKGIQSKKIRYNGEGVNHVSDPRIAQSNSNLQKPTKKTKKTPYKQLPQPKFVYNSDSLGPAPMSTIIIWDLPISTSEPFLRNFVSRYGNPLEEMTFITDPTTAVPLGIVTFKFQGNPQKASELAKNFIKTVRQDELKIDGATLKIALNDNENQLLNRKLESAKKKMLQQRLQREQEEEKRRQKLVEEQKKQELLKKKEKEHQESVKKEKSVEHESTIVSTRDKNLVYKPNSTVLSMRHNHKIISSVILPKDLEKYIKSRPYILIRDKYVPTKKISSHDIKRALKKYDWTRVLSDKSGFFIVFNSLNECERCFLNEDNKKFFEYKLVMEMAIPEGFTNNIRENESKSTNDVLDEATNILIKEFQTFLAKDIRERIIAPNILDLLAHDKYPELVEELKSREQAAKPKVLVTNNQLKENALSILEKQRQLFQQRLPSFRMSHDRTQQHKPKRRNSIIPMQHALNFDDDEDSESHSQSESEDEDEDETTASRPLTPVVSTMKRERSSTITSIEDDIELEEREIKKQKVKVPAIEAEIAPESSPEEGEEEEKEEVEIKQEAEEVDIKFQPTEESPRTVYPEIPFSGDFDLNALQHTIKDSEDLLLAQEVLSETTPSGLSNIEYWSWKSKNRKDVQEISQEEEYIEELPESLQSTTGSFKSEGVRKIPEIEKIGYLPHRKRTNKPIKTIQYEDEDEEKPNENTNAVQSSRVNRANNRRFAADITAQIGSESDVLSLNALTKRKKPVTFARSAIHNWGLYAMEPIAAKEMIIEYVGERIRQQVAEHREKSYLKTGIGSSYLFRIDDNTVIDATKKGGIARFINHCCSPSCTAKIIKVEGKKRIVIYALRDIEANEELTYDYKFERETNDEERIRCLCGAPGCKGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABU0</accession>
    <name>Q5ABU0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">ARG3</name>
        <name evidence="12" type="ordered locus">CAALFM_C603230WA</name>
        <name evidence="11" type="ordered locus">orf19.13053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719171.1">
        <property type="nucleotide sequence ID" value="XM_714078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABU0"/>
    <dbReference type="SMR" id="Q5ABU0"/>
    <dbReference type="FunCoup" id="Q5ABU0">
        <property type="interactions" value="707"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABU0"/>
    <dbReference type="GeneID" id="3639180"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603230WA"/>
    <dbReference type="CGD" id="CAL0000176534">
        <property type="gene designation" value="ARG3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03230W_A"/>
    <dbReference type="eggNOG" id="KOG1504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_0_1"/>
    <dbReference type="InParanoid" id="Q5ABU0"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903269">
        <property type="term" value="C:ornithine carbamoyltransferase inhibitor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000176534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="345" mass="38623" checksum="6981BED7346B17CE" modified="2005-04-26" version="1">MMSSVRTITTTRLLSTTPIKATASSQTPRHLINIAQLTNDEFSSLINKAYQFKQLVKSDKPSIENHQKLLGKLVALLFTKRSTRTRISTEGAASFFGAQPMFLGKDDIQLGVNESMYDTTKVISSMTSCIFARVNKHQDILDLCQHSSVPIVNSLCDKYHPLQAIADLLTIKEQFGDNLKGLKLTWIGDANNVINDLSIACLKLGINVSISIPKDITFDQDVVEIAEKLAKEQNLTFEIVNDPIIALNNANIVVTDTWISMGEEEQKLAKLKQFQGYQITQEMCKLGKVNSNWKFMHCLPRHQEEVADDVFYSDNSVVFEEAENRLYAAMAVIDGFVINKGDLLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AED9</accession>
    <accession>A0A1D8PJM2</accession>
    <name>BBP_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BBP</name>
        <name type="synonym">MSL5</name>
        <name type="ordered locus">CAALFM_C303300CA</name>
        <name type="ORF">CaO19.329</name>
        <name type="ORF">CaO19.7961</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720024.1">
        <property type="nucleotide sequence ID" value="XM_714931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AED9"/>
    <dbReference type="SMR" id="Q5AED9"/>
    <dbReference type="FunCoup" id="Q5AED9">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AED9"/>
    <dbReference type="EnsemblFungi" id="C3_03300C_A-T">
        <property type="protein sequence ID" value="C3_03300C_A-T-p1"/>
        <property type="gene ID" value="C3_03300C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638361"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303300CA"/>
    <dbReference type="CGD" id="CAL0000178990">
        <property type="gene designation" value="MSL5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03300C_A"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016864_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AED9"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="PRO" id="PR:Q5AED9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000256145" description="Branchpoint-bridging protein">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="3">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CCHC-type" evidence="2">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="455" mass="50078" checksum="6905857724197F1B" modified="2005-04-26" version="1">MSNRGRQPSGPPPSRKRETKWSGKPKRYANFGAQSFDTVITGHLTQEQLDAYQRYFRIEEISNFLSVAKQQHKSIVDVLPSAKVDETDHYKRDPSPPPKYDKNGNRTNTRERRVTEALEKERHELVELAASSIKNYMIPSNYRRPSRTVERLYVPVKDYPDINFVGFLIGPRGNTLKKLQEDSGARLQIRGKGSVKEGKSSDGFGSSQTGTDIQDDLHVLITADSPLKISKAVKLVNEIIDKLIFSPQGMNFMKRDQLKELAVLNGTLRETKPFDPEAHEKKQQQQMDITKIVCKICGNIGHIARDCKQNNGKRPLDDNAENEPTTINKKARTDVPPPPPPPPPPAPPSSSTEISKQVPPPPPPPPPPAPSAAASGFATTENYKQGLVPPPPPPPPPPPPPVRSALVNFENNSKVLLTKEKEESGSSELKNTGESSSSSSGVPPSPPPPSSNVPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEN1</accession>
    <accession>A0A1D8PJJ5</accession>
    <accession>Q5AF18</accession>
    <name>CCPR_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c peroxidase, mitochondrial</fullName>
            <shortName>CCP</shortName>
            <ecNumber evidence="2">1.11.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CCP1</name>
        <name type="ordered locus">CAALFM_C302480CA</name>
        <name type="ORF">CaO19.238</name>
        <name type="ORF">CaO19.7868</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="4">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719937.2">
        <property type="nucleotide sequence ID" value="XM_714844.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEN1"/>
    <dbReference type="SMR" id="Q5AEN1"/>
    <dbReference type="BioGRID" id="1221383">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AEN1">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AEN1"/>
    <dbReference type="PeroxiBase" id="3406">
        <property type="entry name" value="CalCcP02"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_02480C_A-T">
        <property type="protein sequence ID" value="C3_02480C_A-T-p1"/>
        <property type="gene ID" value="C3_02480C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638350"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302480CA"/>
    <dbReference type="CGD" id="CAL0000199533">
        <property type="gene designation" value="CCP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02480C_A"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AEN1"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="PRO" id="PR:Q5AEN1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000023">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="3">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000045287" description="Cytochrome c peroxidase, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Tryptophan radical intermediate" evidence="1">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="366" mass="40682" checksum="59860ED332DB3EDA" modified="2017-03-15" version="2" precursor="true">MATFAPHISKITKSSTKFNYGRIAKTFLGVAGSAAIATYFYNNGNPFNNNNNNNNNNGGSKNAAKALFGASAGANVKIAKVPEGKSASDYQKVYNDIATKISENLEFDENAGYYGQLLRLAWHTSGTYDKSDNSGGSYGGTMIFAPEEFDPENAGLQVGREFLMEFLVKYPWISRGDLWTLGGVAAVQESGGPKIEWRPGRVDDNTASKVPPNGRLPDASKDGKYVKDLFARMGFNERETVALLGAHVLGRCHKHNSGYDGPWGPSFNQFTNVFYTTLLGDWHVKKWDGKKQYEDDETGEFMMLPTDMALKEESYFLKYVKMYADDQDLFFKDFAKAFSKLISNGIKYPADSKPILFKTLDEQDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AG56</accession>
    <accession>A0A1D8PNK1</accession>
    <name>YPT35_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">YPT35</name>
        <name type="ordered locus">CAALFM_C502980CA</name>
        <name type="ORF">CaO19.11798</name>
        <name type="ORF">CaO19.4323</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PX domain binds phosphatidylinositol 3-phosphate (PtdIns(3)P) which is necessary for peripheral membrane localization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720629.1">
        <property type="nucleotide sequence ID" value="XM_715536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AG56"/>
    <dbReference type="SMR" id="Q5AG56"/>
    <dbReference type="FunCoup" id="Q5AG56">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AG56"/>
    <dbReference type="EnsemblFungi" id="C5_02980C_A-T">
        <property type="protein sequence ID" value="C5_02980C_A-T-p1"/>
        <property type="gene ID" value="C5_02980C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637816"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502980CA"/>
    <dbReference type="CGD" id="CAL0000199935">
        <property type="gene designation" value="orf19.11798"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02980C_A"/>
    <dbReference type="eggNOG" id="ENOG502S5IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070610_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AG56"/>
    <dbReference type="OMA" id="QWFMTNV"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="PRO" id="PR:Q5AG56"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000333492" description="Endosomal/vacuolar adapter protein YPT35">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="167" mass="19494" checksum="C60A772263E34D0B" modified="2005-04-26" version="1">MNSDTTPTHRNKSNSISQLNKVLPVPIELHNGESLEQHQQNHLNHITNVIVGEYHLISGEFGKSYMTWQIKITINDLDYSSIVLYKRYNEIYQLRQDLLKIFPPHDHTITTNIVPSLPPKDNLSLDRLMMSKNWLEERRKGLQWFLSNVLLNPVFQNCSVVKQFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH58</accession>
    <accession>Q3MPB2</accession>
    <name>Q5AH58_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">SEC1</name>
        <name evidence="4" type="ordered locus">CAALFM_C702320WA</name>
        <name evidence="3" type="ordered locus">orf19.13833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721320.1">
        <property type="nucleotide sequence ID" value="XM_716227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH58"/>
    <dbReference type="SMR" id="Q5AH58"/>
    <dbReference type="FunCoup" id="Q5AH58">
        <property type="interactions" value="847"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AH58"/>
    <dbReference type="GeneID" id="3636935"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702320WA"/>
    <dbReference type="CGD" id="CAL0000174130">
        <property type="gene designation" value="SEC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02320W_A"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AH58"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000174130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="779" mass="89635" checksum="330ED25AD527D7E5" modified="2005-04-26" version="1">MSKNKDPGSLINIQHDYILNKIKSVQQRGQLYNLIIDDKMESVLYNVLTKEELLRIVASIEKIDAKRRQGTFMTAIYLIDVNIYNLKCIIGDVQTRKYKNGIALFPIYQDSRTQDFWLKKFWNQPNVLTFFNNHIEFLNANYFALETKVFLVDNKTSNSMPIYYNPNCIEFVMPQVQLVANALLNLVVSMEEYPLIRFYNPQDGDYDAKRLPELIADAFQAQLDDYCRLNENYPPPSVASKPRAILLITDRTMDLYSPLLHEFSYQAMAMDIVESLERTGKYKYKSENEKGEIMEVEAKLENENDEDWVNLRHLHIIESSELIFNKISELVKNNPLMIDRSKATTSSDLMYIVAHLKGFDEERRQLTLHKTLIDECLDINASRKLAEFAADFEQTCCAEGVSFEGERNKHLHDDLIILLARDDLHINDKMRLVLIYAFYRGGLIRADFEKLIRFIGVNDKYITGLVEKCFNNVEKLGFQIFKKNVKDKPFHKEMYHVINNEGTYNTSRFTPGIKRIMQNAGKYSLDREWFPYFRDQPLDEDIPTNNTRISSTTSTSTRTTNSAGKDLHTSGSLRNPRIKAAWASSSSTLSSSRNINTLGSQAKNKQRIFCFVAGGMTYSEIRSIYELSSSMNKDFYIGSESILKPRDFLIGLQSIDKNKTPENLDLNIYQELNKPTDPPLHVFEDGIPKPKKIINQPQNQFQQQIQQQQLMYQNTHPNANNGGNEQSSPSSSSSSAPPSHYQKRQTPGGNLDNIGNIGSPTSTVDSKEKKKSRLKKFFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-06-18" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH87</accession>
    <accession>A0A1D8PGT7</accession>
    <name>STP4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator STP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">STP4</name>
        <name type="ordered locus">CAALFM_C203220CA</name>
        <name type="ORF">CaO19.8527</name>
        <name type="ORF">CaO19.909</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="4">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2913" last="2925">
            <title>Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.</title>
            <authorList>
                <person name="Garcia-Sanchez S."/>
                <person name="Mavor A.L."/>
                <person name="Russell C.L."/>
                <person name="Argimon S."/>
                <person name="Dennison P."/>
                <person name="Enjalbert B."/>
                <person name="Brown A.J."/>
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            <dbReference type="DOI" id="10.1091/mbc.E05-01-0071"/>
        </citation>
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    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
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            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
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    <reference key="6">
        <citation type="journal article" date="2006" name="Eukaryot. Cell" volume="5" first="180" last="191">
            <title>Cellular and molecular biology of Candida albicans estrogen response.</title>
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                <person name="Cheng G."/>
                <person name="Yeater K.M."/>
                <person name="Hoyer L.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/EC.5.1.180-191.2006"/>
        </citation>
        <scope>INDUCTION</scope>
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        <citation type="journal article" date="2006" name="PLoS Pathog." volume="2" first="E21" last="E21">
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                <person name="Kalachikov S."/>
                <person name="Subaran R."/>
                <person name="Nobile C.J."/>
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                <person name="Mitchell A.P."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.0020021"/>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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    <reference key="2">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
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        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_716373.1"/>
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        <property type="gene ID" value="C1_02790W_A"/>
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    <dbReference type="GeneID" id="3636872"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102790WA"/>
    <dbReference type="CGD" id="CAL0000192484">
        <property type="gene designation" value="TIF34"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_02790W_A"/>
    <dbReference type="eggNOG" id="KOG0643">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
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    </dbReference>
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        <property type="term" value="C:nuclear periphery"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="term" value="P:cytoplasmic translational initiation"/>
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    </dbReference>
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        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000365361" description="Eukaryotic translation initiation factor 3 subunit I">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <sequence length="350" mass="38232" checksum="45D6396905515032" modified="2005-04-26" version="1">MRPIKLMGHERSLTQVKYNREGDLLFSVAKDNAASIWYSSNGERLGTLEGHQGVIWSIDVDPETHLCATGGGDLAIKLWKVENGQCVYTWDSPSPVRRVAFSPDGKKLLAIADQVMGHIGTVSVFDINDDDATLSQQKAEPSLVIETKSEGSKATVAGWSGDGDYIIVGHDNGYVSKYDSKTGKLVTSLQAHGIHNEEKNVSITDIQFAPEDRSYFITSSKDKTATLIDVDTFEILKVYKADAPMNTAAITPVKDFVILGGGQEARNVTTTAESQGKFEARFYHKIFEEEIGRVKGHFGPLNTVAVHPDGTGYSSGGEDGFIRVHTFDKSYQDFLFDAERTERAAAAGTI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJB1</accession>
    <accession>A0A1D8PJ97</accession>
    <name>VATA_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>V-type proton ATPase catalytic subunit A</fullName>
            <shortName>V-ATPase subunit A</shortName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TFP1</name>
        <name type="ordered locus">CAALFM_C301630WA</name>
        <name type="ORF">CaO19.9249</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Mol. Biol. Cell" volume="22" first="687" last="702">
            <title>Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans.</title>
            <authorList>
                <person name="Leach M.D."/>
                <person name="Stead D.A."/>
                <person name="Argo E."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="21209325"/>
            <dbReference type="DOI" id="10.1091/mbc.E10-07-0632"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUMOYLATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Fungal Genet. Biol." volume="71" first="58" last="67">
            <title>Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albicans.</title>
            <authorList>
                <person name="Jia C."/>
                <person name="Yu Q."/>
                <person name="Xu N."/>
                <person name="Zhang B."/>
                <person name="Dong Y."/>
                <person name="Ding X."/>
                <person name="Chen Y."/>
                <person name="Zhang B."/>
                <person name="Xing L."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="25220074"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2014.08.012"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:25220074). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:25220074). Mediates oxidative stress response, filamentous growth, and plays an important role in virulence (PubMed:25220074).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is a probable target for sumoylation.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Leads to a defect in vacuolar acidification and higher sensitivity to oxidants such as H(2)O(2) or menadione. Reduces strongly virulence in mice.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330831.1">
        <property type="nucleotide sequence ID" value="XM_019475286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJB1"/>
    <dbReference type="SMR" id="Q5AJB1"/>
    <dbReference type="FunCoup" id="Q5AJB1">
        <property type="interactions" value="1165"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJB1"/>
    <dbReference type="EnsemblFungi" id="C3_01630W_A-T">
        <property type="protein sequence ID" value="C3_01630W_A-T-p1"/>
        <property type="gene ID" value="C3_01630W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636662"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301630WA"/>
    <dbReference type="CGD" id="CAL0000187512">
        <property type="gene designation" value="TFP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01630W_A"/>
    <dbReference type="eggNOG" id="KOG1352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AJB1"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="PHI-base" id="PHI:3321"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
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        <property type="entry name" value="ATPase_V1-cplx_asu"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
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    </dbReference>
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        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
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        <property type="entry name" value="ATP-synt_ab_N"/>
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    </dbReference>
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        <property type="entry name" value="ATP-synt_ab_Xtn"/>
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        <property type="entry name" value="ATP-synt_VA_C"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
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    </dbReference>
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        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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    <keyword id="KW-0926">Vacuole</keyword>
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            <begin position="1"/>
            <end position="617"/>
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    <feature type="binding site" evidence="2">
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            <begin position="257"/>
            <end position="264"/>
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        <ligand>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="25220074"/>
        </source>
    </evidence>
    <sequence length="617" mass="67607" checksum="D1573ED986E7807F" modified="2017-05-10" version="2">MAGALENATKEIKRLSLEDTHESQYGQIYSVSGPVVVAENMIGCAMYELVKVGHDNLVGEVIRINGDKATIQVYEETAGVTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKDESQSIYIPRGIDVPALSRTTQYDFTPGKLKVGDHITGGDIFGSIYENSLLDDHKILLPPRARGTITSIAESGSYNVEDTVLEVEFDGKKHKYSMMHTWPVRVPRPVAEKLSADYPLLTGQRVLDSLFPCVQGGTTCIPGAFGCGKTVISQSLSKFSNSDVIIYVGCGERGNEMAEVLMEFPELYTEISGRKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKATALGSPDRIGSVSIVAAVSPAGGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKYYDSNYPEFAQLRDKIREILSNAEELEQVVQLVGKSALSDSDKITLDVATLIKEDFLQQNGYSSYDAFCPIWKTFDMMRAFISYYDEAQKAVANGAQWSKLAESTSDVKHSVSSAKFFEPSRGQKEGEKEFSELLSTISERFAEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKB6</accession>
    <name>Q5AKB6_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Mrv4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">MRV4</name>
        <name evidence="3" type="ordered locus">CAALFM_C504210CA</name>
        <name evidence="2" type="ordered locus">orf19.11385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000559">
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    </dbReference>
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        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="37"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000193387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="256" mass="28284" checksum="8306FB2A3A7620D7" modified="2005-04-26" version="1">MSPQAVTASIIRGSQVVVTTIIFAVSIKALAVLGIYYDKSKPTFYITVVAALDIIYFCYTLLLTPLVFKNSSPSIIPTASEFILYTLNLAASCISTINSPTVLCDEFYYSDTIDLCHIHQCLHGFSVTNWVLFTISFMMILYCTFIPEIKRHGVKHTLSPSQFYISCIIIDDNPKSIEVIASESASLDEANIHDESEIGMAPTVYATNNTSSLDANNAIVDSNLESSEDEKSIQKIPIEAVYEKTDISKPYASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKV4</accession>
    <name>Q5AKV4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dal7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DAL7</name>
        <name evidence="9" type="ordered locus">CAALFM_C113850CA</name>
        <name evidence="8" type="ordered locus">orf19.12490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722226.1">
        <property type="nucleotide sequence ID" value="XM_717133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKV4"/>
    <dbReference type="STRING" id="237561.Q5AKV4"/>
    <dbReference type="GeneID" id="3636130"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113850CA"/>
    <dbReference type="CGD" id="CAL0000193894">
        <property type="gene designation" value="DAL7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13850C_A"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="Q5AKV4"/>
    <dbReference type="OMA" id="FLWLMPD"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000193894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="509" mass="56086" checksum="E5836C907999170D" modified="2005-04-26" version="1">MSLNGKTDLEKSGARVSVTASTVSENQTTGFELYEKAQELSFEEEEAIRKKVVWKVDMRIVPLLCITYTLQFLDKLSLNYAAAYTLKEDLNLYGQRYSWCAAIFNFGYLAGALPANYVIQKLPVAKFTGCMLFLWSIILIGHIGLQNYGGILVIRFLLGLFESMISPSCMAICNNFYTVKNQPLRMCIFLSFNGVATIVGSLLSWGLGHADESKLKIWKLIFLVIGLMNFVWSGIFLWLCPDSPKSVKFLTEDEKAVLIKEVATNNQGLGETRFKKSQAVEALQDLFVYFVALIGLACGVINGGTSNFASSLIKGFGFTGIQATALQMPLGAVELVVVVAAGIVVFTVKNMRCIVLFVICIPPLAGLIGLHVIPLTHRWALVGCSFLQFIIGGPVILCWILSNANVSGSSKKTIANGIWFVMYAAGNIISPNIFYAREAPKYRSGIIGLISSYCGIMVLAIAIRLVFMHRNRKRNLEQGGYNEQIAEQAVLDGFKGLTDFENAGFRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKW1</accession>
    <name>Q5AKW1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C113790CA</name>
        <name evidence="3" type="ordered locus">orf19.12483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722220.1">
        <property type="nucleotide sequence ID" value="XM_717127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKW1"/>
    <dbReference type="SMR" id="Q5AKW1"/>
    <dbReference type="FunCoup" id="Q5AKW1">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AKW1"/>
    <dbReference type="GeneID" id="3636141"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113790CA"/>
    <dbReference type="CGD" id="CAL0000188080">
        <property type="gene designation" value="orf19.12483"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13790C_A"/>
    <dbReference type="eggNOG" id="KOG2313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AKW1"/>
    <dbReference type="OMA" id="CLGGFGK"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000188080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="121" mass="13746" checksum="C7FAB6EF5356B085" modified="2005-04-26" version="1">MLRSFIRRMSSAKPPQISHSETPGPIESSIISKITNEFKPLYFKIDNDSHKHAHHAGIRGAKNKTESHFRLEIVSDVFEGKSLSARHRLVYSLLANELKNDGVHALQMKTKTPEEINKTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALU6</accession>
    <name>Q5ALU6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C201690WA</name>
        <name evidence="14" type="ordered locus">orf19.9055</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722529.1">
        <property type="nucleotide sequence ID" value="XM_717436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALU6"/>
    <dbReference type="SMR" id="Q5ALU6"/>
    <dbReference type="FunCoup" id="Q5ALU6">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALU6"/>
    <dbReference type="GeneID" id="3635728"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201690WA"/>
    <dbReference type="CGD" id="CAL0000185815">
        <property type="gene designation" value="orf19.9055"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01690W_A"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ALU6"/>
    <dbReference type="OMA" id="LTWMLSG"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000185815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW27215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="176" mass="19501" checksum="63886055EE2D13BE" modified="2005-04-26" version="1">MISRIGLLKRPTVSTLNNYVKLQSTLALKRYTSTVPATSNQEQEILVAQRKNRPTSPHLQIYEPQLTWIMSSFHRITGVAMAGAFYALTCGFAATSILNIPFDTTTLVSAFTTLPTFAQYGIKAICAYPFVYHIGNGIRHLVWDFGKELTIPGVYRTGYAVLAATAVIGSYLAFLW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALV2</accession>
    <accession>A0A1D8PGF4</accession>
    <name>SLA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SLA1</name>
        <name type="ordered locus">CAALFM_C201640WA</name>
        <name type="ORF">CaO19.1474</name>
        <name type="ORF">CaO19.9049</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="42" first="981" last="993">
            <title>Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.</title>
            <authorList>
                <person name="Murad A.M."/>
                <person name="d'Enfert C."/>
                <person name="Gaillardin C."/>
                <person name="Tournu H."/>
                <person name="Tekaia F."/>
                <person name="Talibi D."/>
                <person name="Marechal D."/>
                <person name="Marchais V."/>
                <person name="Cottin J."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="11737641"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02713.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="Curr. Genet." volume="56" first="309" last="319">
            <title>Candida albicans SH3-domain proteins involved in hyphal growth, cytokinesis, and vacuolar morphology.</title>
            <authorList>
                <person name="Reijnst P."/>
                <person name="Jorde S."/>
                <person name="Wendland J."/>
            </authorList>
            <dbReference type="PubMed" id="20383711"/>
            <dbReference type="DOI" id="10.1007/s00294-010-0301-7"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="3485" last="3497">
            <title>Cdc28-Cln3 phosphorylation of Sla1 regulates actin patch dynamics in different modes of fungal growth.</title>
            <authorList>
                <person name="Zeng G."/>
                <person name="Wang Y.M."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="22787279"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-03-0231"/>
        </citation>
        <scope>INTERACTION WITH CLN3 AND PAN1</scope>
        <scope>PHOSPHORYLATION BY CDC28-CLN3 AND PRK1</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Required for assembly of the cortical actin cytoskeleton and for hyphal growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the PAN1 actin cytoskeleton-regulatory complex (By similarity). Interacts with PAN1 and CLN3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Peripheral membrane protein</topology>
            <orientation>Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Cell tip</location>
        </subcellularLocation>
        <text>Localizes in patches that are found concentrated at the hyphal tip.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is regulated by NRG1 and MIG1.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal SH3 domains are important for actin cytoskeleton assembly but not for localization.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylated by the CDC28-CLN3 complex and by PRK1. CDC28-CLN3 phosphorylation regulates cortical actin patch dynamics, as well as PRK1 phosphorylation and SLA1 association with PAN1. Rapidly dephosphorylated upon hyphal induction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722523.1">
        <property type="nucleotide sequence ID" value="XM_717430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALV2"/>
    <dbReference type="SMR" id="Q5ALV2"/>
    <dbReference type="BioGRID" id="1218833">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5ALV2">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALV2"/>
    <dbReference type="EnsemblFungi" id="C2_01640W_A-T">
        <property type="protein sequence ID" value="C2_01640W_A-T-p1"/>
        <property type="gene ID" value="C2_01640W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635739"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201640WA"/>
    <dbReference type="CGD" id="CAL0000198859">
        <property type="gene designation" value="SLA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01640W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003674_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ALV2"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:actin cytoskeleton-regulatory complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="C:SLAC complex"/>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="term" value="F:lipid binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="CDD" id="cd09532">
        <property type="entry name" value="SAM_SLA1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_Sla1p_1"/>
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        <property type="entry name" value="SH3_Sla1p_2"/>
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        <property type="entry name" value="SH3 Domains"/>
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    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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        <property type="entry name" value="DUF1720"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="SHD1"/>
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    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
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    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
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    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
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    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
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    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0254">Endocytosis</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <feature type="chain" id="PRO_0000424376" description="Actin cytoskeleton-regulatory complex protein SLA1">
        <location>
            <begin position="1"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="SH3 1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SH3 2" evidence="2">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SH3 3" evidence="2">
        <location>
            <begin position="396"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1207"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11737641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20383711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22787279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="1257" mass="138870" checksum="981BF1339AA506BA" modified="2005-04-26" version="1">MSSIYIGVYKALYDYAAQAEEELNIKQNDLLYLLEKSDIDDWWKVKKRVVATGEEIVDEPSGLVPSTYIEEAPVIKTATALYDYDKQTEEELSFNENDKFNVFDLNDPDWILVGDLAKEKFGFVPSNYIQLDSTAEPAQHQQQQPQQVFQPPPQQQQAIPQQQTQIPINNFPPPPTHKDRTPDFPAPPAHRDRSPEHPPPTPEKDYPRMFEQEPRSLGSRYDRQPEGREEEEDEAPPPMPSRPTGSNIVAPEPVVGRSNTYEQEENVEHSEHSYDGEFFTWYIDEVDGRKKRAIKLSIGQGLVIIKPNTTNPKKLRMRSSSSLDNQWRIKDLITFNNEKKHVFLEFKNPAASLELHAGSKDVAEAIMAILGDLKGAEAAHGLREVAKASKASANERNRKIGRLLYDFEVQGDDELDCKEGDEVYIIDQKKSKDWWMVENIATRRQGVVPSTYIEIISTSNLDKLTDGPLRRKSTKSKGRVVETKDKRSSHHRTREERDRIREKDRAQRDKAPTSQTEQDKSMPNFHRVRTWIDSSGTFKVEAEFLGCVEGKIHLHKTNGVKIAVAADKLSVEDLEYVERVTGTSLEQYKEQVMKQQAKRAKSKSKSGATATPSSTNETKYASSATAAINDIAPPKPTRPQTTTQVSNNGAPLYDWFDFFLECGVDIGNCQRYTLNFEREQMDENILEDISPSLLRTLGLREGDIIRVMKYLDAKFDRKKTPEAPQQNGGLFIDKNGNLKNNSSSTEISKVSADALPSPVKTQVTSFTPVNESTQNNNKIEDDAWAMKPAARSSEDLLKPSPQPQTPQYTGALSDLVNIKPVGTSNENKAKTEQIPVEPSAPALQPMKTSNTAATSSIPPQGPGVTPQRTGTLVPVQKTGGLVPVQRTGAGLVPVQTGGYLPAQPTGFVPITAQPTGFIPIQATGILQPQLTFGIVPLQTGTSTFNANNKTAPPRPDTAPPPITTFGQQPTFQPAFVPLQTGVITMPQTTFGGQSQQLPTQITGGAPPQTSFNQPALVPTQRTGGQITGGFVPQSNFGKQITGGFMDTNTLSFGQQITGNAQQQPPPSTSFGQQITGGLPATSFGQQITGGFPQTSFGQQMTGGAPQTSFGQHITGGNMPNTSFGQPFSQQATSNPFPQMANQFTQQQQYQQQQPVMNQFQQQPQQQQQPFYNQFQSQPNLNQMTNMFQNTSISSPATFNQQIPTTTFGQQPQFEGFGSQPLQSQPTGMGFGNAPLQSQPTGKRANLQAATPDNPFGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-11-28" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AP53</accession>
    <accession>A0A1D8PEW5</accession>
    <name>CBK1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase CBK1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cell wall biosynthesis kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CBK1</name>
        <name type="ordered locus">CAALFM_C110380CA</name>
        <name type="ORF">CaO19.12375</name>
        <name type="ORF">CaO19.4909</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="J. Bacteriol." volume="184" first="2058" last="2061">
            <title>Conserved serine/threonine kinase encoded by CBK1 regulates expression of several hypha-associated transcripts and genes encoding cell wall proteins in Candida albicans.</title>
            <authorList>
                <person name="McNemar M.D."/>
                <person name="Fonzi W.A."/>
            </authorList>
            <dbReference type="PubMed" id="11889116"/>
            <dbReference type="DOI" id="10.1128/JB.184.7.2058-2061.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="5456" last="5477">
            <title>Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans.</title>
            <authorList>
                <person name="Song Y."/>
                <person name="Cheon S.A."/>
                <person name="Lee K.E."/>
                <person name="Lee S.Y."/>
                <person name="Lee B.K."/>
                <person name="Oh D.B."/>
                <person name="Kang H.A."/>
                <person name="Kim J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="18843050"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-03-0272"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH MOB2</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Mol. Biol. Cell" volume="22" first="2458" last="2469">
            <title>CDK-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans.</title>
            <authorList>
                <person name="Gutierrez-Escribano P."/>
                <person name="Gonzalez-Novo A."/>
                <person name="Suarez M.B."/>
                <person name="Li C.R."/>
                <person name="Wang Y."/>
                <person name="de Aldana C.R."/>
                <person name="Correa-Bordes J."/>
            </authorList>
            <dbReference type="PubMed" id="21593210"/>
            <dbReference type="DOI" id="10.1091/mbc.E11-03-0205"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002683" last="E1002683">
            <title>The NDR/LATS kinase Cbk1 controls the activity of the transcriptional regulator Bcr1 during biofilm formation in Candida albicans.</title>
            <authorList>
                <person name="Gutierrez-Escribano P."/>
                <person name="Zeidler U."/>
                <person name="Suarez M.B."/>
                <person name="Bachellier-Bassi S."/>
                <person name="Clemente-Blanco A."/>
                <person name="Bonhomme J."/>
                <person name="Vazquez de Aldana C.R."/>
                <person name="d'Enfert C."/>
                <person name="Correa-Bordes J."/>
            </authorList>
            <dbReference type="PubMed" id="22589718"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002683"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH BCR1</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 8 9">Serine/threonine-protein kinase required for wild-type hyphal growth and transcriptional regulation of cell-wall-associated genes. Involved in the biofilm formation through phosphorylation of the master regulator of biofilm formation BCR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7 9">Interacts with MOB2 and BCR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Bud neck</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell tip</location>
        </subcellularLocation>
        <text>In yeast cells, localizes to the cell cortex of small- and medium-budded cells and to the bud neck in large-budded cells. During hyphal growth, is present at the tip of hyphae and in the region of the septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723591.2">
        <property type="nucleotide sequence ID" value="XM_718498.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AP53"/>
    <dbReference type="SMR" id="Q5AP53"/>
    <dbReference type="BioGRID" id="1217932">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AP53">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AP53"/>
    <dbReference type="EnsemblFungi" id="C1_10380C_A-T">
        <property type="protein sequence ID" value="C1_10380C_A-T-p1"/>
        <property type="gene ID" value="C1_10380C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634838"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110380CA"/>
    <dbReference type="CGD" id="CAL0000198853">
        <property type="gene designation" value="CBK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10380C_A"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_2_1"/>
    <dbReference type="InParanoid" id="Q5AP53"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="PRO" id="PR:Q5AP53"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036168">
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        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="term" value="P:membrane raft organization"/>
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        <property type="term" value="P:positive regulation of filamentous growth"/>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
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        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="AGC-kinase_C"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
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        <property type="entry name" value="Pkinase"/>
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        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000420233" description="Serine/threonine-protein kinase CBK1">
        <location>
            <begin position="1"/>
            <end position="732"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="3">
        <location>
            <begin position="648"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="281"/>
            <end position="310"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="159"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="171"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="172"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="185"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="2 4">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="341"/>
            <end position="349"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="11889116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="18843050"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="21593210"/>
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    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="22589718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <sequence length="732" mass="84500" checksum="7A9CF033CDEF170A" modified="2017-05-10" version="2">MNFDQLTDEQKQQLYLQHLQQQQQLQQQQQQLQQQQHQLQQQQQSYHLQQQQAAYQQQNQAQLQQDDSYMDEDTSELINQPPVQLDHGSPIRQQPQMSAFMPSPRFAQSESFDNHLNVDPNNTERFTSMDSMNFQPPASTFTQLGNGSSTNLSEISSGQNSLLSNHSVNNLPTALTSDTSPPVQQHPQFQPQQQQQQQQPQQQQIFQQQQQQQQQQQQPQQSRAVVNQSVSTEAANSDMTGSNTKYVYFERKPNLLSKTTQDKAASIKLTLENYYTSSVSHAIERNQRRLELENKIANEDIGSSEERKNRQLQNLGKKESQFLRLKRTKLALEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMFNKDQLAHVKAERDVLAGSDSPWIVALYYSFQDSQYLYLIMEFLPGGDLMTMLIRWEVFTEDITRFYIAECVLAIEAIHKLGFIHRDIKPDNILIDNRGHVKLSDFGLSTGFHKTHDSNYYNKLLEKEPSNTHLQPNQLTSGRNSVMVDAIHLTMSNRQTMQTWRKSRRLMAYSTVGTPDYIAPEIFIHQGYGQECDWWSLGAIMFECLIGWPPFCSENPHDTYRKILNWQESFQIPEDVHLSPEAEDLIKRFLTSAENRIGRYGGAEEIKQHPFFRGVDWDSIRDVQAPFVPRLSSMTDTRHFPTDDLASVPDNPAMSKAMEQRELDAKNGGGRKNPKEDLPFIGYTYSRFDYLTRKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APB4</accession>
    <name>Q5APB4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TFIIE subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">TFA1</name>
        <name evidence="7" type="ordered locus">CAALFM_C109860CA</name>
        <name evidence="6" type="ordered locus">orf19.12314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723537.1">
        <property type="nucleotide sequence ID" value="XM_718444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APB4"/>
    <dbReference type="SMR" id="Q5APB4"/>
    <dbReference type="FunCoup" id="Q5APB4">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5APB4"/>
    <dbReference type="GeneID" id="3634850"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109860CA"/>
    <dbReference type="CGD" id="CAL0000198769">
        <property type="gene designation" value="TFA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09860C_A"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_2_0_1"/>
    <dbReference type="InParanoid" id="Q5APB4"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000198769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="394" mass="44512" checksum="91CD92C20C9535EA" modified="2005-04-26" version="1">MDDSVRSLIRFVSRGFYSTPYVLILDAVLRHSVLSEDDLIHLLGIKRKELRSLCNRLVDDRLLTNHIQREDNGQQKYVTRTYFFIHITEAIDSIKWKVHSIVNVLKQEMSSFGNPQGYVCPRCGNKVSQLDAISMLSEDKTEFICDVCQGVLIEDDSSQQATLKQERLEKLMKQLDPIIKFLKIIDETQIRDNDFESALLQAIPAQSATTASYTLSNRVSSKSRSNAQAMQNAAARSQATLHVSITANDENYEREQMEKENRRQKLEQNALPSWHSNSTVGQSNTFGKLEDEEDDHMGTPSSIKEEGEQGEANTDSKEIYGSDSKEGTTEQSSVMATPEPQSTVNNNSNFNNVSAELKEREAQDALAAYYAQLAEQDADEDDDDDDDEEFDDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APH1</accession>
    <name>Q5APH1_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C109330WA</name>
        <name evidence="3" type="ordered locus">orf19.12257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723479.1">
        <property type="nucleotide sequence ID" value="XM_718386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APH1"/>
    <dbReference type="SMR" id="Q5APH1"/>
    <dbReference type="FunCoup" id="Q5APH1">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5APH1"/>
    <dbReference type="GeneID" id="3634802"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109330WA"/>
    <dbReference type="CGD" id="CAL0000197859">
        <property type="gene designation" value="orf19.12257"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09330W_A"/>
    <dbReference type="eggNOG" id="ENOG502RY79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106785_0_0_1"/>
    <dbReference type="InParanoid" id="Q5APH1"/>
    <dbReference type="OMA" id="WAYIATI"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000197859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23335" checksum="AB93F083B8D9AF6D" modified="2005-04-26" version="1">MPLAHNLNKVTKNISKSTGSLHIKGRKFKQLNRATLRDKKLQQRKSQSLERKSNELSIVFFIQSLLQEKNTANDGGDEDEEEGENFKEFSNKKQFTLDEMKQIIEKFIHQNDDELQRLQSERRKGRPPTNRQTILEEKLKYDLEIYRTGFKIPDLTDQLTVERIKEWNGTTGATTTMKFIRVSKDMTELPTTTNEIEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCJ1</accession>
    <name>A0A1D8PCJ1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">MRP20</name>
        <name evidence="6" type="ordered locus">CAALFM_C101600WA</name>
        <name evidence="5" type="ordered locus">orf19.10858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718173.2">
        <property type="nucleotide sequence ID" value="XM_713080.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCJ1"/>
    <dbReference type="SMR" id="A0A1D8PCJ1"/>
    <dbReference type="FunCoup" id="A0A1D8PCJ1">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCJ1"/>
    <dbReference type="GeneID" id="3640224"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101600WA"/>
    <dbReference type="CGD" id="CAL0000174219">
        <property type="gene designation" value="MRP20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01600W_A"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCJ1"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000614">
        <property type="entry name" value="Mrp20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000174219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW25850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="293" mass="34388" checksum="AFBD15AD57552841" modified="2017-01-18" version="1">MDGNTRSGRLVASIWKSFTRSIHYKPLAPNKYPKVNVNDVDLNPPRYGFRRIRPPIIAQSPTKTLFPSVEIAKKYIEEGKRVPNRFMDQFGPDHARKEFEEFQEKLALEEPHFKIGGKQIYFPQGRICLLRSNAKHTPYQAKFLVPKSMNKMDLRDYLWHIYGLRALNITVQLQPARWKRSPYGLGRYRSPQLKKMTVDMMEPFIWPEVPQAKLDLLKTQRDNSLKTVQQNTAVGADKLKPLEVYDGMYKEQVQPQRFVSEKFKREAEKNIKLYNKVVQSRSDRKSLENYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCV2</accession>
    <name>A0A1D8PCV2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C102770WA</name>
        <name evidence="3" type="ordered locus">orf19.2965.1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Scherer S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713581.2">
        <property type="nucleotide sequence ID" value="XM_708488.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDE2"/>
    <dbReference type="SMR" id="A0A1D8PDE2"/>
    <dbReference type="FunCoup" id="A0A1D8PDE2">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDE2"/>
    <dbReference type="GeneID" id="3644780"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104740WA"/>
    <dbReference type="CGD" id="CAL0000174538">
        <property type="gene designation" value="LPG20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04740W_A"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDE2"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018456">
        <property type="term" value="F:aryl-alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000174538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="348" mass="39908" checksum="81F4D26FF7B22E67" modified="2017-01-18" version="1">MSIELKYNNLGESGLKIAPIIVGCMSYGDKRWAQWVLEDEEKIFQILKRCYDVGLRTFDTADVYSNGKSEELIGKFIKKFNIPRDRIVILSKVFFPVDPQTPGFSLATRDNFPVLDYYNSQGLSRKHVLQAVQNSVERLGTYIDVLQVHRLDKDTPKKEIMKTLNDVVDQGLARYIGASSMKVTEFAQLQFIAEQNHWHKFISMQNYYNLIHREEEREMIPFCKDNFISKVGIIPWSPIARGVLTRPVDTSSENSRDKLDKTFKLLHLDELTDADKEIISRVEKIAKDNKVSMAVVATAWVISKGCNPIVGLSSVERVDDILKATVLKLTEEDIKYLEEPYVPKQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE70</accession>
    <name>A0A1D8PE70_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C107590CA</name>
        <name evidence="11" type="ordered locus">orf19.10302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711728.2">
        <property type="nucleotide sequence ID" value="XM_706636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE70"/>
    <dbReference type="SMR" id="A0A1D8PE70"/>
    <dbReference type="FunCoup" id="A0A1D8PE70">
        <property type="interactions" value="884"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PE70"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PE70"/>
    <dbReference type="GeneID" id="3646673"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107590CA"/>
    <dbReference type="CGD" id="CAL0000177244">
        <property type="gene designation" value="orf19.10302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07590C_A"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE70"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="789"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000177244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117688" checksum="04C517B560E158A0" modified="2017-01-18" version="1">MSKSQPKSQMKGLTQFIVDLRNSKDQDEEDKKINLEINNIKTKFNNNNLNGYQKKKYVCKLIYIYLIGNPNLVDFGLKESFQLLQSNIFSEKKLGYIAVATLLDNEKILINGKNQKSKKFTSSKQRLNYILENIHTDLVRDLQSNNEEFNCLAIQFIASVFTINADSDNTIIKESDENSHLWLELVDMVYASVTSPISSPIVKSKASIALKSLLKLYPQVIITNNNWIPRLLKLIDDKDYSTIISSIPLLQFILSLEPQYVKSVMPSIASQLSQIVIEGKCPEPYFYYDSPAPWLIVKLLQLVEQLFLLVDQQGSQVLTIDKLDDNTINQLRQVVAKSIQNASQPIKGLPNRNSQSSILFQAVSLAVFLEASPEAISGAMNALLMLLTSNETNTRYLSLDALIKLTARSNSNYLSSSKDNFDKALNIIMKLLRDKDISVRRKALDLLYTICNFENYNIIISKLLDYFPNADFLLKSELAIKIAVMAEKFATDSTWYVTTMLKLLSIGGGSNSNGVGFMSNEVWERIVQIVVNNESLQKKTCKLLINLLRRPFDQRNVASPSQHQQQQPPPQALPLSESLIKVAAFVLGEFGDQINDIEDLNVIVQFQLLFDAYFKVSLLTRAMLLSTFLKFLVKFPNESFVPDIVDLFEIETQSIDLEIQTRAYEYLKLVTLQSDFKLAQNVIKPFPAFNNKVENPLMNRLGSVSRIVGVNRSRSLVMAKNIKSKPVSRAIPEEEEEVEEFNTTIENDPFNEESATAAATTTTTTTTTTNNNNGSHSLKLSPNWYAGYHRMLHFDAGIFYEDQLIKITYRIMKNTNELTIKFTIINNARKNINKDITGFTILNLESLANIQDPNYTLHIQTLPESTIKDKTQMEIYIKVRNIIENNESPVLSMTYMCGGSFNQLNLKFPVLLLKTITPTTLSTFEEFNKRWNQIGQLLGIEQGQFIHKVILTHRYNSSNISRLLSRVGLAIIKTTDDTLNGPIYVASAGILHTQKSNYGVLITIRGTDEIGKELQIVVRCTGGGVAEVICSTLKEIFTGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEN6</accession>
    <name>A0A1D8PEN6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type 2C protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">PTC1</name>
        <name evidence="9" type="ordered locus">CAALFM_C109260CA</name>
        <name evidence="8" type="ordered locus">orf19.12249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </evidence>
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        <source>
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                <person name="Dungan J."/>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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</entry>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
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    <dbReference type="Proteomes" id="UP000000559">
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        <property type="term" value="F:protein methyltransferase activity"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHQ0</accession>
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        <submittedName>
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    <gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="259" mass="29416" checksum="8B8095E7584DF2E9" modified="2017-01-18" version="1">MSIIFRKRLDSDRNIDASLYFGNIDPQVTELLMYELFIQFGPVKSINMPKDRILKTHQGYGFVEFKNSADAKYTMEILRGIRLYGKALKLKRIDAKSQSSTNNPNNQTIGTFVQSDLINPNYIDVGAKLFINNLNPLVDESFLMDTFSKFGTLIRNPIIRRDSEGHSLGYGFLTYDDFESSDLCIQKMNNTILMNNKIAISYAFKDLSVDGKKSRHGDQVERKLAESAKKNNLLVTKTSKAGTTKGNKRKNKPHKVTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="11">Translation initiation factor eIF4G</fullName>
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        <name evidence="10" type="ordered locus">orf19.11082</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="3643880"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208760CA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="707"/>
            <end position="946"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="67"/>
        </location>
    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="60" mass="6953" checksum="798DB3FEF2A771C7" modified="2017-01-18" version="1">MAAGHIARYIRHAPAIKPHVPAYVKWSSKLLGATMWFWIMLRIKEDGPVMFGLKLPFEHH</sequence>
</entry>
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            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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        <source>
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        </source>
    </reference>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="cal:CAALFM_C210330CA"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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        <name evidence="8" type="primary">ZCF8</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Antimicrob. Agents Chemother." volume="48" first="3064" last="3079">
            <title>Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.</title>
            <authorList>
                <person name="Karababa M."/>
                <person name="Coste A.T."/>
                <person name="Rognon B."/>
                <person name="Bille J."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="15273122"/>
            <dbReference type="DOI" id="10.1128/AAC.48.8.3064-3079.2004"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2017" name="PLoS Pathog." volume="13" first="e1006699" last="e1006699">
            <title>The yeast form of the fungus Candida albicans promotes persistence in the gut of gnotobiotic mice.</title>
            <authorList>
                <person name="Boehm L."/>
                <person name="Torsin S."/>
                <person name="Tint S.H."/>
                <person name="Eckstein M.T."/>
                <person name="Ludwig T."/>
                <person name="Perez J.C."/>
            </authorList>
            <dbReference type="PubMed" id="29069103"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1006699"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2018" name="Cell. Microbiol." volume="20" first="e12841" last="e12841">
            <title>Identification of Candida albicans regulatory genes governing mucosal infection.</title>
            <authorList>
                <person name="Meir J."/>
                <person name="Hartmann E."/>
                <person name="Eckstein M.T."/>
                <person name="Guiducci E."/>
                <person name="Kirchner F."/>
                <person name="Rosenwald A."/>
                <person name="LeibundGut-Landmann S."/>
                <person name="Perez J.C."/>
            </authorList>
            <dbReference type="PubMed" id="29575428"/>
            <dbReference type="DOI" id="10.1111/cmi.12841"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2021" name="MBio" volume="12" first="e0302021" last="e0302021">
            <title>A Fungal Transcription Regulator of Vacuolar Function Modulates Candida albicans Interactions with Host Epithelial Cells.</title>
            <authorList>
                <person name="Reuter-Weissenberger P."/>
                <person name="Meir J."/>
                <person name="Perez J.C."/>
            </authorList>
            <dbReference type="PubMed" id="34781731"/>
            <dbReference type="DOI" id="10.1128/mbio.03020-21"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7">Transcription factor functions primary as a transcriptional repressor to maintain vacuole homeostasis when the fungus faces fluctuations in nitrogen (PubMed:34781731). Binds the 5'-TAAATCCG-3' consensus sequence upstream of genes encoding vacuolar and intracellular vesicle trafficking components (PubMed:34781731). Acts also as a negative regulator of filamentation in host tissues (PubMed:34781731). Plays a role in cell-substrate adherence, a fundamental property that enables the formation of biofilms (PubMed:22359502). Especially modulates interactions with host epithelial cells and governs mucosal infection (PubMed:29069103, PubMed:29575428, PubMed:34781731).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is repressed by fluphenazine treatment.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5 6 7">Decreases adherence to silicone substrate and host epithelial cells (PubMed:22359502, PubMed:29069103). Increases fungal load in tongues in an oropharyngeal candidiasis (OPC) model (PubMed:29575428). Leads to alterations in vacuolar morphology and luminal pH and renders the fungus resistant to nigericin and brefeldin A, two drugs that impair vacuole and associated functions (PubMed:34781731).</text>
    </comment>
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    <dbReference type="eggNOG" id="ENOG502S81P">
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    <dbReference type="InParanoid" id="A0A1D8PJ72"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463338" description="Zinc cluster transcription factor ZCF8">
        <location>
            <begin position="1"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 3">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15273122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="29069103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="29575428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="34781731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="915" mass="106575" checksum="F7C7357400405880" modified="2017-01-18" version="1">MESNLSNTESPSPSPSSPSSSATPTTTNISTNTTNNENPGIHTSATTNTTPSSADTTTKPKRQRRSYSCGPCKLLKIKCDLQIPCTACKKFNRVNRCLLQPPQPPSQQELSKIQERKKRTTIKKMKLSNEFVQAYNVNPNALPSMISTMETTSKNYEKKTQKHKMNQISLDKDSSPKENTSKTLKQLNNFNGNRKDTQLTKNSNSMSPHSLIEIQRHHLSFQQPQMNKQQLHPISYITSVSSPSSALTSTSLNFPQGSQQEDVIQYLLTMDSQKTIDLTMVDIKRIKRLLPNDFGLFKSMFDCYLNTVNPIAIDMQDFSEIFKQSNLVYNKLLSIDDENPKNLSINVSFTLIELRNLSLFFLILVNGLLFDFRGEKPPLDSTRQTHNNRYTNFLLERSIYKSKHDVIEDWIKISKFIKLKVLAYESLTDIIFLIDWYMILKNYYDYENMVVENYLEFNNLLNYLVLNNDFINTIEDPYNEVGRNSNEEEEEEDAATTSVDENEVVYPDTRQFKVLSKYWIQLRLIEIDYTFFQFKGSLLFANQLKGTVVPHKKILKTLYKDVELDPITTHLMKIWGLYYKRSKNTTSVREIIKDYLLLYCNMMGTLKDELNEFETNKPLELPNSRSINLKDIELLIKNQRLLHLFVRWLSFIRIESNYFPSLRYTTYFTTVMNLFNHFNYLDDKSNNNVLSMIFNNYSLSNIKLFYQCLVFQGIFLVLLKNALNGNNNYPNNNPSTSLPKFKINLEKIYQFSLHQYQTTLNKILNHEVCRELQENITLFKLIANLSIEFNQYLINPITNNNPKDKDLDLTELIYDLKSKISSSNWDLLLNYFFGSKDNFARYIEKIWDLFQYLKIDPTTTTTTSTVSTTDIPITSKIYLNDQLIDDVMGKFSGFKFDENVVNEYFKHCVEPNIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKE0</accession>
    <name>A0A1D8PKE0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH/NAD(+) kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C306110CA</name>
        <name evidence="7" type="ordered locus">orf19.7393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716634.1">
        <property type="nucleotide sequence ID" value="XM_711541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKE0"/>
    <dbReference type="SMR" id="A0A1D8PKE0"/>
    <dbReference type="FunCoup" id="A0A1D8PKE0">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKE0"/>
    <dbReference type="GeneID" id="3641761"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306110CA"/>
    <dbReference type="CGD" id="CAL0000187953">
        <property type="gene designation" value="orf19.7393"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06110C_A"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKE0"/>
    <dbReference type="OMA" id="MRMRLCC"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000187953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="592" mass="65704" checksum="CEC786462DCF1D26" modified="2017-01-18" version="1">MSHKTQSQLSSQMKNLNTPPIDFNSTSSNNTMPSEPNSQPQQQQSQPEAKTEPQTIRPATFTTSGNSSSSSISTLSADIIQPLHQLSINNNNSTVTQPAPQSSSFQRRNNPQRFNRNQLNVYTDFNSTTSSASSISSSPKDFFTREPPRIHSKLICEEIASANNRAAKEVLSRLSTDELRSVKSHTELAETANGVRMLAKNLSRATIQLDVRAIMIITKARDNGLIYLTKEVVEWILDQHPHITIYADEKLAKSKRFNPESIIANYPNGCKKLKYWNKKLTTKNPEIFDLVLTLGGDGTVLFASNLFQKIVPPILSFSLGSLGFLTNFEFSAFRTVLSKCFDSGVKANLRMRFTCRVHTDEGKLICEQQVLNELVVDRGPSPYVTHLELYGDGSLLTVAQADGLIIATPTGSTAYSLSAGGSLVHPGVSAISVTPICPHTLSFRPILLPDGMFLKVKVPSSSRATAWCSFDGKVRTELKKGYYVTIQASPFPLPTVMSSKTEYIDSVSRNLHWNIREQQKPFSSYLKPETRQSIAESERLDNLHISSEQDESNHEEPEITEDFDINYTDNERDSSSSTPSEESNEECANTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKF6</accession>
    <name>A0A1D8PKF6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SUMO ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">MMS21</name>
        <name evidence="13" type="ordered locus">CAALFM_C306200CA</name>
        <name evidence="12" type="ordered locus">orf19.7413</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716078.1">
        <property type="nucleotide sequence ID" value="XM_710985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKF6"/>
    <dbReference type="SMR" id="A0A1D8PKF6"/>
    <dbReference type="STRING" id="237561.A0A1D8PKF6"/>
    <dbReference type="GeneID" id="3642265"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306200CA"/>
    <dbReference type="CGD" id="CAL0000188305">
        <property type="gene designation" value="MMS21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06200C_A"/>
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    </evidence>
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        <source>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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    <accession>A0A1D8PKY5</accession>
    <name>A0A1D8PKY5_CANAL</name>
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        <name evidence="2 3" type="primary">TLO8</name>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Chibana H."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
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        <property type="match status" value="1"/>
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        <location>
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            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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    <accession>A0A1D8PLN1</accession>
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    <gene>
        <name evidence="6 7" type="primary">SAS10</name>
        <name evidence="7" type="ordered locus">CAALFM_C402790CA</name>
        <name evidence="6" type="ordered locus">orf19.10232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720467.2">
        <property type="nucleotide sequence ID" value="XM_715374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLN1"/>
    <dbReference type="SMR" id="A0A1D8PLN1"/>
    <dbReference type="FunCoup" id="A0A1D8PLN1">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLN1"/>
    <dbReference type="GeneID" id="3637899"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402790CA"/>
    <dbReference type="CGD" id="CAL0000185070">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02790C_A"/>
    <dbReference type="eggNOG" id="KOG3118">
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    <dbReference type="InParanoid" id="A0A1D8PLN1"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="490"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
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        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
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        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000185070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLR0</accession>
    <name>A0A1D8PLR0_CANAL</name>
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        <recommendedName>
            <fullName evidence="3">ribonuclease T2</fullName>
            <ecNumber evidence="3">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">RBT7</name>
        <name evidence="11" type="ordered locus">CAALFM_C403100WA</name>
        <name evidence="10" type="ordered locus">orf19.10196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720434.1">
        <property type="nucleotide sequence ID" value="XM_715341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLR0"/>
    <dbReference type="SMR" id="A0A1D8PLR0"/>
    <dbReference type="STRING" id="237561.A0A1D8PLR0"/>
    <dbReference type="GeneID" id="3637925"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403100WA"/>
    <dbReference type="CGD" id="CAL0000180106">
        <property type="gene designation" value="RBT7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03100W_A"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLR0"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T2 family ribonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111155" description="ribonuclease T2" evidence="9">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000180106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="325" mass="36858" checksum="478B342569F96F73" modified="2017-01-18" version="1">MLSQSFLIALAVIPVTLASPYYNPYFGKYFHGQRTSGDSSSSGNFYPVKDCSAFIDQNPETSWSCHNKSPVSSANSCCFEENGIILSTQFWDYNTTLLEIAVNGSTSDIVEAELKSKLDTVYNDLSRTFTIHGTWDDFCNGSYPQYCNKSLEVSDEKDNLTHILVDQFKEVELYNIMSKYWIDTIASNVDSSASTALWEHEYNKHGTCMTTLSPSCFTSQSYTRFENVVNFYKKTVEIWSQLDTFEFLAAAGIYPTVSRKYKLSQVQEALQKAHGAEVYVGCLNNSISEIWYFYNLQGSILTGTYKPIDTTTNTKCKDEVWYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLR7</accession>
    <name>A0A1D8PLR7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">NCP1</name>
        <name evidence="25" type="ordered locus">CAALFM_C403180WA</name>
        <name evidence="24" type="ordered locus">orf19.10187</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720425.2">
        <property type="nucleotide sequence ID" value="XM_715332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLR7"/>
    <dbReference type="SMR" id="A0A1D8PLR7"/>
    <dbReference type="FunCoup" id="A0A1D8PLR7">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLR7"/>
    <dbReference type="GeneID" id="3637839"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403180WA"/>
    <dbReference type="CGD" id="CAL0000197218">
        <property type="gene designation" value="NCP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03180W_A"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLR7"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000075">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="264"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="439"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="457"/>
            <end position="459"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="473"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <begin position="599"/>
            <end position="600"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="606"/>
            <end position="610"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50902"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000197218"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="680" mass="76635" checksum="5D30C13E1AA01B47" modified="2017-01-18" version="1">MALDKLDLYVIVTLVVAVAAYFAKNQFLSKPQDTGFLSNDGAGGSSRNILETLKKNNKNTLLLFGSQTGTAEDYANKLSRELHSRFGLNTMVADFADYDFDNFGDITDDILVFFIVATYGEGEPTDNADEFHTWLTDEADTLSTLRFTVFGLGNSTYEFYNAIGRKFDQLLEEKGGERFAEYGEGDDGTGTLDEDFLSWKDGVFDSLKNNLNYEEKELKYEPNVKLTERDDLTVDDSHVSLGEPNKKYINSQGVDLSKGPFDHTHPYLAKITKTKELFNSKDRNCVHVEFDISDSNLKYSTGDHLAVWPSNSDENIKQFLKCFGLEDKENTVIELKALDSTYSIPFPSPITYGAVIRHHLEISGPISRQLFLSIAGFAPNEETKATLTRIGNDKQEFASTITRRKFNIADALLFASKGKAWVDVPFEFIIENVQHLTPRYYSISSSSLSEKQLINITAVVEAEVESDGRAVTGVVTNLLKNIEIEQNNTNETPVVHYDLNGPRNKFSKFKLPVHVRRSNFKLPKNTTTPVILIGPGTGVAPLRGFVRERVQQVKNGVNVGKTILFYGCRNEHDDFLYKQEWSEYASVLGDKFEMFNAFSRQDPSKKVYVQDKIVENYKIVNELLNNGATIYVCGDASRMARDVQAAIAKIVAKDRDISQESATELVKSWKVQNRYQEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM72</accession>
    <name>A0A1D8PM72_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C404990CA</name>
        <name evidence="7" type="ordered locus">orf19.11262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_712093.2"/>
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    <dbReference type="Proteomes" id="UP000000559">
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        <property type="entry name" value="LAAT-1"/>
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    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
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        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="20"/>
            <end position="37"/>
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        </location>
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        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
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        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000185570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="466" mass="52758" checksum="A77E7B2E7CEF9B57" modified="2017-01-18" version="1">MTHSLRLFDNFLSNISKTSSIISLTIWLFTQIPQIILNHKRRDVSLSISFVGLTFLADIINLTYQISIKDSPYSILLVYMIILDLIIISQYFYYSRYFKKPVSPPPPPQQQQQQPTLVDRILGAAFVTDLVSAMNIKAQQPEYHHQKQTSPVHFDWVQILPIVCCFLYIISRIPQIRRNYIRKSTTGLSLYMVLFTVLGTIFNLLSIVTDTNLYNVLSIKIFLIGSLVIVLMDGALLYQFWLYRKHISAHENDTVDIDEQPQWYVKNQPLVFYQSFEQHKHKQQELAFSASVPSITSSLHFSNSIHPIKSNQSRGRKLVKSPGEQTSLLDESLIPSSTAIAVSMATPPPPQHYIVSSSARYQSFHRFNSHQNPQSKIIPQSLTSSSVGSATSLIPSIIGNISSVNKKLMDGSKIPFSPIDFLTDDYYNSNNNKNKNSHSHSHSSREGTNGSVVIGSTNMYYGSIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM87</accession>
    <name>A0A1D8PM87_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">SSK2</name>
        <name evidence="15" type="ordered locus">CAALFM_C405030CA</name>
        <name evidence="14" type="ordered locus">orf19.11257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717180.2">
        <property type="nucleotide sequence ID" value="XM_712087.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM87"/>
    <dbReference type="SMR" id="A0A1D8PM87"/>
    <dbReference type="FunCoup" id="A0A1D8PM87">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM87"/>
    <dbReference type="GeneID" id="3641144"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405030CA"/>
    <dbReference type="CGD" id="CAL0000187689">
        <property type="gene designation" value="SSK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05030C_A"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM87"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:MAP kinase kinase kinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:cellular response to oxidative stress"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
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        <property type="term" value="P:lipid oxidation"/>
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        <property type="term" value="P:MAPK cascade"/>
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        <property type="term" value="P:neuron projection morphogenesis"/>
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        <property type="term" value="P:p38MAPK cascade"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:stress-activated protein kinase signaling cascade"/>
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    </dbReference>
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        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1338"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00056158"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000187689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW29244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1483" mass="168057" checksum="B5172BDFEBD5A72F" modified="2017-01-18" version="1">MSDIPPTNESNSDSTLINQKNNDNNDNKETGKDISSTHTHHRVTFAEQQPISTSSRKSSLLRKHSSNNTSSDSDKRPSIISRNSNPDIHRDSLPPLNRGPSYNGNYTRSHSSRNVNANNTINTGVTSDSNSNNNVDSNAPISSPTTPAISSPPANGKYFNLVLPAGKSREKSPGRHSKEGHTRSRSFTKQQHGIGSTSSQSSSQYLAQEKAYLRKMRNQSVDDYYSKGIPGAHEVSKADDNDDEDDDDEEHSSFDGGDNANLLAAIDDDKYQIDYSMALSLMKNSNVNLRKIANLNTDDTDDPAIIERLEWQSMLTSVLTGDVVRSEKTKIININNPDSTQESYLHATFKENLWFGIRAKIFNRTEDEQRKIVAYRRTLVDQLIDDVMKFEIDYENSTDNPIRDQVKTILDRYDQACSLWKTLEDMYSDKPACRSEEFQNRIDALTAWLTITDAISRETKSLRLWIGNDELDITKSPVEVSSSNAATSTSKIVKKIFDEDNKSLAERLMKEKDVQTIFRKRIFKPIAPWMIKSKDTYIRLGVIFENMKLPDYLHDLLQICIIPVRLIKEIVIVRLGYAMKLQNPTLMMIDQMLDDFKSYITVALEVKSGISEYKEPDEDRKWLISDLFDSELEDFDNVILRCVRYFLVLLNRKLLDSSRSPTTFRTFKEPEELEEAWNFLKPLGHYVDGGSVVVAEEITMLASRLIHRLMAYFNHQIREPTYNGVPQDLIRWYSSTSENFGQLRRKLARFMGEISRDFKNSVVFDIPSQSNCTKTLLEILRSSNHFLVYTGTVETQGTYFFASPELLGNEQEILKILTGSCVGLDPSTDNSHFTDLLHLIRSGSEEHLRYNDDDLDSYDDSNGAYAYVLALCPMKPIVWDGLVVNVDIDSVPITDMKNGELLLVSKLSYYDLHIVRNRFLEVASEVSLGNAGLKQVEYRCSLAKVNQELKKMNRVVFKMCSSVLESVQVIKTRIAELDPVGEYQALINSYFIYARDYGKNSVRTLDPQRKSTIIMKMIQLSIDWVSFICDDCIPTDRKTFRWCVLALEFSMEMIRGINIFLLTEEQFTKLKVKVARCMSLLISHFDIMGARSSEAEKNKLLKWTAQRHNIASSQNDDEYLNKVYHEEVMGQINKIEERRRNLQEEFQSIGRVLDVSDSEYQFLTLLASSFSSVSIRWQKGACIGRGTFGQVFSAVNLDTGGVMAVKEITFHDSQSVKTIVPSIKEEMTVLEMLNHPNVVQYFGVEVHRDKVYIFMEFCEGGSLAGLLTHGRIEDEMVIQVYALQMLEGLAYLHQSGVVHRDIKPENVLLDHNGVIKYVDFGAAKVIASNGRTIGGMTNSSLRKSVKRDGHNNLNSMTGTPMYMSPEAITGTSTDRSGVVDIWSLGCCVLEMATGRRPWANLDNEWAIMYHIAAGHKPQLPSPEQLSEPGRTFLARCLEHDPTKRPSAVELLADPWMVEIRHMAFGNSDVTTTPLSEVAGPVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMH9</accession>
    <name>A0A1D8PMH9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">CWH41</name>
        <name evidence="18" type="ordered locus">CAALFM_C406100WA</name>
        <name evidence="17" type="ordered locus">orf19.11899</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711869.2">
        <property type="nucleotide sequence ID" value="XM_706776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMH9"/>
    <dbReference type="SMR" id="A0A1D8PMH9"/>
    <dbReference type="FunCoup" id="A0A1D8PMH9">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMH9"/>
    <dbReference type="GeneID" id="3646533"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406100WA"/>
    <dbReference type="CGD" id="CAL0000183221">
        <property type="gene designation" value="CWH41"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06100W_A"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMH9"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044650">
        <property type="term" value="P:adhesion of symbiont to host cell"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
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    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
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        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000008">
        <property type="entry name" value="Cwh41p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111170" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="52"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="331"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000183221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW29337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="830" mass="96269" checksum="8D2AF0F97A9C00BD" modified="2017-01-18" version="1">MRLLSWLPFVFLLEVIFASNQIKFDLYDNNELQSNNDTVDLATQYSQISNSSLLWGPYRSALYFGLRPRFPRSLLSGLMWFSINDYEGIGKIRHFYEQHDKMSKANWVSYDPRIGGRQIIDDDECHIKIIIDFVKSDDGLSWGVKIRAKPHKGFENIKTSFIWYSGLEGEQKVIEENGDETTSRTGFLKLENPKNVLGYEGNVKFAGVSEELGAFELEINDGPKTNVHPAGRTDVDPELDPRKAHHYSLTVPDDNVWRARDIFMTMLQESIQKLVEKFGGVEAIPPENLFILRDLQDFEGNLHFVQKVYQGSCEFDVVYNNALTPITERITFENLKFRIQNSLKAFDEKFNNHFELAPPFNSKKYKKFGKEVLSGLLGGLSYFYGDQLVDRETVFDEDSFESYKLEGTFEGPYELFTLVPSRPFFPRGFLWDEGFHLLPLLNYDSDLVLEITKSWFNLIDEDGWIAREQILGKESRSRVPAEFVVQSPQIVNPPTLTLVLTYLLDSVVGNYDTINEPKNVDESLSRENLGGFVLKNPEVLTNYTKQVYPKLKSHLDMFRRTQKGYVEEFDRGTNPEAYRWRGRTLTHCLASGLDDYPRALPADVAELNVDLISWIGIMTRSIRLMAEILNIDEDVETYKNLENDIIDNIEKLHWSPEDKTYCDVSVNDDDENIFVCFKGYISLFPFLTKLIPEANTDKLEHIINLISNPEELWTPYGIRSLSKADEFYKTGEDYWRSPIWIPINYLILDSIQDYYIRSKHHMSTNLQEKFAKTYHDLRINIVKNVFDQADKTGFVWEQYNDETGEAQRAKNFLGWSSLVLIMMTMPEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMM1</accession>
    <name>A0A1D8PMM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 20">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 20">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">TOP2</name>
        <name evidence="25" type="ordered locus">CAALFM_C406600WA</name>
        <name evidence="24" type="ordered locus">orf19.10391</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19 20">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 20"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715530.2">
        <property type="nucleotide sequence ID" value="XM_710437.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMM1"/>
    <dbReference type="SMR" id="A0A1D8PMM1"/>
    <dbReference type="FunCoup" id="A0A1D8PMM1">
        <property type="interactions" value="1247"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMM1"/>
    <dbReference type="GeneID" id="3642777"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406600WA"/>
    <dbReference type="CGD" id="CAL0000175071">
        <property type="gene designation" value="TOP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06600W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PMM1"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097047">
        <property type="term" value="C:DNA replication termination region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097046">
        <property type="term" value="P:replication fork progression beyond termination site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000011">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 19 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16 19 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 19 20" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="22">
        <location>
            <begin position="498"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="23">
        <location>
            <begin position="752"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1122"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1244"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1274"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1406"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1434"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="19">
        <location>
            <position position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000256" key="18">
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            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
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        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000175071"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AOW29383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
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            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1461" mass="165363" checksum="895415CEC1E17424" modified="2017-01-18" version="1">MSESESDYFTDGSEDDFVPTSKKSTKKNASSKSKQPLGDATNSTVSSSRSSTPKPTNASETYQKLSQLEHILKRPDTYIGSVEKTKTEMWCFDAETESMVFKEVTIVPGLYKIFDEILVNAADNKIRDPSMKNIRVKIDAENNIIEVMNDGKGIPIEMHTKENMYIPELIFGNLLTSSNYDDDQKKVTGGRNGFGAKLCNIFSTQFEVETADLNMGKLYKQSWTNNMSNVSKPKITTLRTKKEYTKITFRPDLSKFDMDCLDNDLLSVLRRRVYDLCGTVKNCNIYLNDKRLNISSFKGYVEMYVKAIKERSPEPEPQDGTIKNFTTIVHEVFNDRWEVAFAVSDGSFNQVSFVNSIATTSGGTHVKYVSDQIINKLVETLSKKEKGKKKLMIKPQEVRDNMFLFINCLIENPAFTSQTKEQLTTKVSQFGGKDKFVANDNLINRILKTSIVDKIRAIANANEDKALQKADGSRKSRIKGQVNLVDANKAGTKDGHNCTLILTEGLSAMNLAVAGLSVVGRDYYGCFPLRGKLLNVREASADQISKNAEINSLKQIIGLQHKKVYTAENIKSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIPGFLLEFITPIVKVTVKARGAGGKRVIPFYTMPEFEHWRDTEGKQCRWTQKYYKGLGTSTPMEAREYFTALDRHLKRFHALQGEDKDYIDLAFSKKKADERKEWLQGFLPGTHLDPEITEIPISDFINKELILFSMSDNVRSIPSVLDGFKPGQRKVLYGCFKKKLRSEIKVAQLAGYVSENTGYHHGEQSLVQTIIGLAQNFVGSNNINVLKPNGSFGSRAAGGKDFSAARYIFTELSEITRKIFNPLDDPLYTYVQDDEQTVEPEWYLPVLPMILVNGAEGIGTGWSTNIPSYNPKDLVTNIRRLMNGEELQEMTPWYKGWGGDLEPMGPQKFKVSGRIEQIDSNTVEITEIPVKTWTNNVKEFLLSGFGNEKTQPWIKDMEEHHTTSIRFVVKLTDAEMQKSLRIGLLERFKLVSSLSLANMVAFDPMGRIKKYNDVLEIIKDFYYVRLEYYQKRKDYMTDNLQNQLLMLSEQARFIKMIIEKQLSVANKKKKQLVALLEEHNFTKFSKDGKPIKSSEELLTGDDADEEEETQEQEGDEDVGNTSVANIQEGEPEQAAHVPETIYSSYDYLLGMAIWSLTYERFMRIMQQRDQKEAELNALLSKSAKDLWNQDLDEFLAEFDKFLLRDEQERESLASNGKKKSTKRRAKATATKDQPNNKKVKVEPKEKKSISAKPVVKKEASNEPQASSSSKPKEKDDILSFFSSSSSSAKKITKPSGRATSNKEIETITLFSDDDDDEDIFNLNSSSSTKVKKEAKSRSATPAAEKSKKSKSSGKQSILDELEDLEILGNFDKPEPKERRTRETASTTKRNTKKKPVIIDSDDEDEDEEDDIVMSDGDDDDDFIVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNH1</accession>
    <name>A0A1D8PNH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">OPY1</name>
        <name evidence="4" type="ordered locus">CAALFM_C502370CA</name>
        <name evidence="3" type="ordered locus">orf19.11720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720554.2">
        <property type="nucleotide sequence ID" value="XM_715461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNH1"/>
    <dbReference type="SMR" id="A0A1D8PNH1"/>
    <dbReference type="STRING" id="237561.A0A1D8PNH1"/>
    <dbReference type="GeneID" id="3637793"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502370CA"/>
    <dbReference type="CGD" id="CAL0000194103">
        <property type="gene designation" value="OPY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02370C_A"/>
    <dbReference type="eggNOG" id="ENOG502S0C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNH1"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="448" mass="51689" checksum="836CACB924B015BE" modified="2017-01-18" version="1">MVDRLETTGPVTTTMTTTTIASPQPQPLQNSTIINASPKSDVNKIHSRTSTIDTSATSTFDNNKLLISTVLYKRSRHTRQWKKKWVVLRKCQLSYYKDSKEYKPLKVYHGEDLLSFSIIPDHTKNHFALYTSNKVLHFRAPDETTFHQWVDTLNEYFNSQENEDDDTQLLDQQQQEEEEEEDSLNKEEPRVSDVDPSPEEDHGSQVSSPPANNQQTLPIHSIQNKQQAQVRRSTSLTDSINTSTEFSDCSSEAWSTIDSPITPSNAVNMNNGSSLFNTLDVPNEEDERRRIEPSVSSHPPQPPPPIESTKNKPQSSTPNTDLVESVIEQGYMTVLKKKYNRNLTKRVYLVLTNVNLKVYKTQEDYRTDSQQQQQQQSFELIYKNYPINDILDIIELDPMTSKYQWCLLIITPLKRIRFCCHDEEDMMKWFSALKAVVVTQKKKQKEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNH8</accession>
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            <fullName evidence="7">Chromatin-binding protein</fullName>
        </submittedName>
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        <name evidence="7" type="ordered locus">CAALFM_C502610CA</name>
        <name evidence="6" type="ordered locus">orf19.11751</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720583.2">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNH8"/>
    <dbReference type="STRING" id="237561.A0A1D8PNH8"/>
    <dbReference type="GeneID" id="3637780"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502610CA"/>
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    <dbReference type="eggNOG" id="KOG3548">
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        <property type="component" value="Chromosome 5"/>
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    </dbReference>
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        <property type="project" value="CGD"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1047"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="19"/>
        </location>
    </feature>
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            <end position="31"/>
        </location>
    </feature>
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        </location>
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            <end position="379"/>
        </location>
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        </location>
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            <end position="620"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000186283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNP4</accession>
    <name>A0A1D8PNP4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C503490CA</name>
        <name evidence="2" type="ordered locus">orf19.6658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711411.1">
        <property type="nucleotide sequence ID" value="XM_706319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNP4"/>
    <dbReference type="GeneID" id="3646967"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503490CA"/>
    <dbReference type="CGD" id="CAL0000189210">
        <property type="gene designation" value="orf19.6658"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03490C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQQZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNP4"/>
    <dbReference type="OMA" id="NELGGYN"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000189210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="543" mass="60518" checksum="0299407EA30AA8CA" modified="2017-01-18" version="1">MTLPANFKFKSTEDPKIIEQLYTLCGTEWGGKLTPEQFGSAQAKGNFKYVDEGGRILSYYIEDVNTGTIVATTSVKFCKAFYKPADRSSAISSIPDPSLFGVNNATALLISFVFTHKDYRKLGLAGQCVSKAIEATEKLIIKEKVDSSDESVADNFKKMSIADGTNETDLQLANYYLSKEYIWILYSGVNTYYERFGFKSFPMDFYEVPNTLLTNDVESAIENLIKESKEEKQSPSGKSIRLLLGDNPADQEIIQFILQNKELNIVTEINKLQFHSNLQSDRKSSTSLTNMTNILSMSKLGSSTGLSSVAETNAAAASSSSPGSPGVRRKSSVHHQTIPKFAIKPTYAHYQSNATVNKEMFDYFSEVSQKFANIQGAIVTNEVQQRSYYALWCPLKGQFFITGMGEIQFQGIPSSLPANRPRRASSLSGINELGGYNFKDLEVLVFTALHVAKNLDTHFDKVHISVNDLPEEIPDPVMYDFFINYLPASIQESEGVKEEAKAEVKLLTDAAHSIRVLPMVRKFGSQKSEFDLDWIADGMWCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNU2</accession>
    <name>A0A1D8PNU2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C503940CA</name>
        <name evidence="4" type="ordered locus">orf19.10729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710957.2">
        <property type="nucleotide sequence ID" value="XM_705865.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNU2"/>
    <dbReference type="FunCoup" id="A0A1D8PNU2">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNU2"/>
    <dbReference type="GeneID" id="3647446"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503940CA"/>
    <dbReference type="CGD" id="CAL0000181747">
        <property type="gene designation" value="orf19.10729"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03940C_A"/>
    <dbReference type="eggNOG" id="ENOG502QTZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNU2"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF2">
        <property type="entry name" value="ABR173CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000181747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54329" checksum="B724978DA5ED9742" modified="2017-01-18" version="1">MHLWKSLSQSNKDIRILWGSVFLRMANYGLTNQVLTLYLKSLNINETKIGLFMTLTLIGDTIISYYLTWNADEKIGRRNVMILGTIMMFFSGIVFGLNIQVDNNNNNNNMEVHFYILLMAAIFGVISPSGDETGPFKSVEEASIAHLTPHNHRPEIFAFYGLFATAGAAIGSLLCGILVDYWNLTMGVDIIQCYRYVFLVYSGIALIKFGLMMGLSEKCEIHQKKHASNNNNNNNNNNNNNNNNNNNNNNNNNNNEASLLLETDSVESDDLDNTSILSTGTKISKLSNISKYYLPRLLCIFMLDSLGYGFMPNAWIVYYLKITFELTASSLGILFFITNSVDSISSLPSAYLSKLIGPVKTILFTQIPSAIFFGLTIIPSNYPLVAILLILYFTTSTMDVVPRQVLLTSIMPKQDITKVMGIVNIGKTLARCIGPIITGKLASINKLYVGFIINSCCVLLADMILAINFLHLDEEILLKQSIIQEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNY3</accession>
    <name>A0A1D8PNY3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C504410CA</name>
        <name evidence="13" type="ordered locus">orf19.11410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721838.2">
        <property type="nucleotide sequence ID" value="XM_716745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNY3"/>
    <dbReference type="SMR" id="A0A1D8PNY3"/>
    <dbReference type="STRING" id="237561.A0A1D8PNY3"/>
    <dbReference type="GeneID" id="3636410"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504410CA"/>
    <dbReference type="CGD" id="CAL0000189493">
        <property type="gene designation" value="orf19.11410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04410C_A"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNY3"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000189493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="380" mass="44619" checksum="17BBAA49A826C0F6" modified="2017-01-18" version="1">MTLSSRRRELRASIRENIRQAENFDQEDDADKHIDQELRHLQHSHPQEHEATTNHDATKSINTIKREHEEHAGYNNAYDTIKVKREFDNKQGEDDDEEEEEEYQEENEHTEIPNRRRTRNKRQRIELSNTTVAPQTRTIFKHIDNPDSTICEHCGLAFRNVIDKRNHRRTHSQPKRHVCETCGKKFSQKANLEIHKTHVHHDLILDEYNGELPNQPVEDNSANIFSNDNNTKPPVNLKDVRVFHCNALQCGKGFISHDKLMDHIATEHPNFVPEVKKETKREKKKAQLPKVHECTFEGCDKSFAKISDYKRHYRIHTGERPYICEHCGASFNQRYRLTTHTRIHTGEKPFQCKYCGKTFARGDAVQSHIFSIHRAKGEAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-05-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNZ7</accession>
    <name>GDE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerophosphocholine phosphodiesterase GDE1</fullName>
            <ecNumber evidence="9">3.1.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glycerophosphodiester phosphodiesterase GDE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GDE1</name>
        <name type="ordered locus">CAALFM_C504510WA</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Eukaryot. Cell" volume="4" first="1562" last="1573">
            <title>Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Murillo L.A."/>
                <person name="Newport G."/>
                <person name="Lan C.Y."/>
                <person name="Habelitz S."/>
                <person name="Dungan J."/>
                <person name="Agabian N.M."/>
            </authorList>
            <dbReference type="PubMed" id="16151249"/>
            <dbReference type="DOI" id="10.1128/EC.4.9.1562-1573.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="PLoS Pathog." volume="3" first="E92" last="E92">
            <title>Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.</title>
            <authorList>
                <person name="Xu D."/>
                <person name="Jiang B."/>
                <person name="Ketela T."/>
                <person name="Lemieux S."/>
                <person name="Veillette K."/>
                <person name="Martel N."/>
                <person name="Davison J."/>
                <person name="Sillaots S."/>
                <person name="Trosok S."/>
                <person name="Bachewich C."/>
                <person name="Bussey H."/>
                <person name="Youngman P."/>
                <person name="Roemer T."/>
            </authorList>
            <dbReference type="PubMed" id="17604452"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.0030092"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="33939" last="33952">
            <title>Glycerophosphocholine utilization by Candida albicans: role of the Git3 transporter in virulence.</title>
            <authorList>
                <person name="Bishop A.C."/>
                <person name="Ganguly S."/>
                <person name="Solis N.V."/>
                <person name="Cooley B.M."/>
                <person name="Jensen-Seaman M.I."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
                <person name="Patton-Vogt J."/>
            </authorList>
            <dbReference type="PubMed" id="24114876"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.505735"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline (PubMed:24114876). The choline is used for phosphatidyl-choline synthesis (PubMed:24114876). Required for utilization of glycerophosphocholine as phosphate source (PubMed:24114876). C.albicans can utilize GroPCho through transport and intracellular hydrolysis or through extracellular hydrolysis (PubMed:24114876).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16061"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="EC" id="3.1.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16062"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 6">Expression is positively regulated by the transcription factor PHO4 (PubMed:24114876). Induced during early phase of biofilm formation (PubMed:16151249).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6">Results in altered glycerophosphocholine catabolism (PubMed:24114876). Leads to hypersensitivity to 5-fluorouracil (5-FU) (PubMed:17604452).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GDE1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721845.1">
        <property type="nucleotide sequence ID" value="XM_716752.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNZ7"/>
    <dbReference type="SMR" id="A0A1D8PNZ7"/>
    <dbReference type="FunCoup" id="A0A1D8PNZ7">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNZ7"/>
    <dbReference type="EnsemblFungi" id="C5_04510W_A-T">
        <property type="protein sequence ID" value="C5_04510W_A-T-p1"/>
        <property type="gene ID" value="C5_04510W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636505"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504510WA"/>
    <dbReference type="CGD" id="CAL0000191313">
        <property type="gene designation" value="GDE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04510W_A"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNZ7"/>
    <dbReference type="OMA" id="WTPMEHA"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000845">
        <property type="entry name" value="Glycerophosphocholine phosphodiesterase GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0040">ANK repeat</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000439802" description="Glycerophosphocholine phosphodiesterase GDE1">
        <location>
            <begin position="1"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 1" evidence="1">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 2" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 3" evidence="1">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 4" evidence="1">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 5" evidence="1">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 6" evidence="1">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="817"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16151249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17604452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1162" mass="130854" checksum="CFB280D9215A1F0C" modified="2017-01-18" version="1">MKFGKTYVTHQIPEWSIYYMNYKQLKKIIKSIDSAANTNVDESKYPEVISDTLGSFFYDLDRDIEKVDSFYNTKFKEYNRRLNKIFQVLGYQDGQITHNIESSEELDEIINILIELKSLFRNLKWFAELNHKGFIKILKKLDKKLTSILSQHSGVSVGGVSNHNQEAYMGSRINALPFANGTEASNCLDSIHHILSRIETRNDVVQETIPVENNETSISALIKNDDFEGLKKHITIKSSQKFLISTLNKAALANSTKCIDVIWNQLDMLYDDSDFNGRNFFHQHIISLGKAQFIREEQIVPGEVTNRLIGGDNGPDNSNKNDNPIGLLYILNKLKHKRLILAEDHYHRTPLHYASQYGLVEVTRYLVEFGVKWGLINTSISIDDVSIWGDQEGLTPLHLSIIGKHPKTTETLLGFNKAQTLTCPNLLLLAVRLNSPQILNSLIVEGNIDVNYTDIDHRNETALYIASKLNHPDLVEFLLESNANTEIGENVFGWTPIFIAASEGFMTIVKLLKEYGASYDIVDDSGWLPMEHACLRGHLDVTDLLLPKNEKLLLYDMYHPENNLPRIPSLAASPVLTGSDDGTVSTSSIDKLPEPQKNTVNQFYKQLKNNSSNNVSRSTSPKRNKRYKPVKSFGHRYLNEDESLILLTLGTTDLRDTNVPVELNKVSLAKSFATELDTALSLSITCRHKLTNNPVEPPVVVDLPLEDFHGSATDPISFKLSNDLTVNDVIITFDIIPTYQVNKKVIGRAIALLKDAYTKVGPNLRSLNNSIAIPIIESTNLDILGTIRFEYLQVLPFKHKAMSIARSDTYWKQLVSTRVIGHRGLGKNLSGKKSLQLGENTVESFIAAASLGASYVEFDVQLTKDHVPVVYHDFTVAESGVDIPMHLLTLEQFMGFNTPTEKPTHTVDDEVLTRGKQRAQSSYQLSNNHNDDIEKEFANQRDERMKFTKTWKNQGYKGNLRGSSVASNFVTLRELFRKLPNNVGFNIEVKYPMLDEAQLEDMGEIGVDLNFFVDTILKVIYDENTTGRDIVFSSFHPDICLLLSLKQPTMPVLFLTEAGTAPMYDIRASSLQNAVRFSKKWNLLGIVSNALALIKTPRLAQVVKSMGLVCVTYGTENNEPELAKIQMRAGVDAVIVDSVLAVREGLREHNETMNEFEDSPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP00</accession>
    <name>A0A1D8PP00_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Arginase</fullName>
            <ecNumber evidence="2 12">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">CAR1</name>
        <name evidence="14" type="ordered locus">CAALFM_C504490CA</name>
        <name evidence="13" type="ordered locus">orf19.11416</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 12"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721843.1">
        <property type="nucleotide sequence ID" value="XM_716750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP00"/>
    <dbReference type="SMR" id="A0A1D8PP00"/>
    <dbReference type="FunCoup" id="A0A1D8PP00">
        <property type="interactions" value="1392"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP00"/>
    <dbReference type="GeneID" id="3636503"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504490CA"/>
    <dbReference type="CGD" id="CAL0000174553">
        <property type="gene designation" value="CAR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04490C_A"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP00"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903269">
        <property type="term" value="C:ornithine carbamoyltransferase inhibitor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090369">
        <property type="term" value="F:ornithine carbamoyltransferase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090368">
        <property type="term" value="P:regulation of ornithine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000174553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="317" mass="34329" checksum="787507A7270BC30A" modified="2017-01-18" version="1">MSSIQYKYHPDKKASIITAPFSGGQPKGGVELGPDYILKAGFQKQIESLGWTTDLKEPLEGTDYEKMKTNDKDDFGVKNSKIVSESCQKIHDAVKGSLAEGKLPITIGGDHSIGTATVSASLVHDPSTCVVWVDAHADINTPKTTDSGNLHGCPLSFIMGIDRDSYPPEFSWVPQVLKSNKLVYIGLRDVDDGEKEILRKHNIAAFSMYHVDKYGIGKVVEMALDKVNPNRDCPVHLSYDVDAIDPSFVPATGTRVEGGLSLREGLFIAEEIAQSGLLQSLDIVETNPMLAETEEHVLDTVSAACAIGRCALGQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP58</accession>
    <name>A0A1D8PP58_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">CNB1</name>
        <name evidence="12" type="ordered locus">CAALFM_C505160CA</name>
        <name evidence="11" type="ordered locus">orf19.11492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="173" mass="19435" checksum="72BC8F26E58CF109" modified="2017-01-18" version="1">MGANASILDGFIEDTNFSIEEIDRLRKRFMKLDKDGSGQIDKQEFLSIPGISSNPLATRLMDVFDKDGDGSIDFEEFITGLSAFSGKSDNLNKLRFAFNIYDIDRDGYIGNGELFIVMKMMVGKNLKDEELQQIVDKTLMEADLDGDGKLNFEEFKNAVNTDTIANTLTLNMF</sequence>
</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000192173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="38" mass="4320" checksum="6B677E72F095EE2F" modified="2017-01-18" version="1">MLPPGVILVFCLIFVAFLLVSGVFIQKKLKARKAQQRF</sequence>
</entry>
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        <alternativeName>
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        </alternativeName>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C6_02740W_A"/>
    <dbReference type="eggNOG" id="KOG3466">
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    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:respiratory chain complex I"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Complex1_LYR_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000174836"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="107" mass="12433" checksum="C9CFAC56EB74BDF3" modified="2017-01-18" version="1">MSSPILPFTEANSKRVTSLFRQALRTAYDHSMRWDVYRDATINIRRQFEANKHISSQQELEAVINKTKAKLAEWKHPDPYIPPCRPGGTKYQRNIPVAREPLVPGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQB7</accession>
    <name>A0A1D8PQB7_CANAL</name>
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        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C604120CA</name>
        <name evidence="4" type="ordered locus">orf19.8798</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710427.2">
        <property type="nucleotide sequence ID" value="XM_705335.2"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S20P">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="915"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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            <begin position="100"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000191245"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1083" mass="125760" checksum="1091F006F63FB782" modified="2017-01-18" version="1">MAKSILKDNQNHTAPIVFGDNNNNNNTNTKNDESGITVNSNYNNNNNNNSNNNRRVSFAREVTLHKIDYVENPNNKRRKTDIGITYQDYGIISGDSNLENDYNNSNNGNSMNNINEQDEHEEEQGDETYGEKMLVDSSDEEQEGGHVIDVNDKQEDHEEQTMDLTSVGVPEYMPPIIYDGKSSTDQQYPEVEGEEEEDMELTEGMPRKIEYSSPKENNVVDQNNEDEDITMDVTNVISHIRQSVNQNENHNQVQDNDSNEKSEPANADDTQPMELTQTFETVTRSNIEKPVLQEVTEEQESEDGVEQPDSEKTEIKEQEEEERVLTDQIIDDNDEENADDHKPGNISSNDFSEHMDLTIVDYKKIDYNGPLPEIPRGDGFDNGELSFAMDLTEIQSFVRPRNDNLTPEVKDNEKQEGDQTNNKETGIDDPDTNAITQDTQHNEAKPKENEPQLDEDIENEAMELTQTIPMKIINSHEDTDSISKPSPIVDDLPDESLSQPMELTQIDSKITTGKEESDLGDASQPMDLTQTISNISHDEINTSGIEERVTTTTIPLATTIPLAEITQDDINQEEDEGGEERKEEEKETVVGEEEEGDVSSEDDSFDEDDPNYISVSLSKFLSDIRVQFYDDLELDLNSIPRLSITNSIELPTIHDYIKAKPNLELLELYEFCCNELNKKIIQGRELYNEYEKTVLVNNPILFKKYYSMDDKTKLLINLKIQLIRDFARLKSKKTWYDWRNQLTENLIDKLDEEINSLTIDKQEIIKDINRLNELYDKTRIYLKGLNHKFNELIRLKNEINEIPPNELNKLQLDVRKRKQDIVEINKEIEIKLSELSTIKKNLDTSNNKKLTLQTQLNDLENQFNQIRKYDNLEIKLILQKYQFLQHLTNLKYLKTIESGQKISFLFDDSIICEFDFINNNISYTVKQNNFKNKLLIEIYEQFVIDGDKQDHTITDKFQMFHRNWQWLKKIDSDFYYISLKFPIELKIVHHQDNDNDDDGKKALEFTIKYYNFKHDYKVLICGKIDINKFLIHQLFNTHNNIEFTGEIIYQRGEINNKSFRDQISNDLKVFDKQILNNLIIVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR96</accession>
    <name>A0A1D8PR96_CANAL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="6" type="ordered locus">CAALFM_C703090CA</name>
        <name evidence="5" type="ordered locus">orf19.12611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716968.1">
        <property type="nucleotide sequence ID" value="XM_711875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR96"/>
    <dbReference type="SMR" id="A0A1D8PR96"/>
    <dbReference type="STRING" id="237561.A0A1D8PR96"/>
    <dbReference type="GeneID" id="3641401"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703090CA"/>
    <dbReference type="CGD" id="CAL0000193063">
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
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    </dbReference>
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        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:NADP binding"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000193063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="415" mass="47674" checksum="B6C53D195F53304A" modified="2017-01-18" version="1">MVEKRIAIVGGGPSGIITLRSLLDEGFTSVTLFERKNKLGGCWNLTPPEQINFEQLSKKQWDVDPIPETIPTTVPHTTVQRFMDTATYPYLETNVEDIAMEFDKPFPKDTISKHGKDSPFRHFTEINQYLHDLADLKYVTFDTSVELIEKKNEQWRLVLRKFGQTQDYIYEEFFDNVVVASGHFDVPFVPEIPGLQQFSELDDTLVIHSKQFRSRDDFKDKQVVVVGASVSAMDSIRDILPVAKRAITSQKPTTEPHVYFGTEAFDHDGIEKRGQIVKIEDHTIHFHDGTSTFADAIILGTGFLYHYPFLPKFPELKELIFDANDPSLAFVGHNTPGLTFKLFQWQAILVARVFAGKGNVPTTIRNDPTIHPDFNQYYETLREASCGALPKWNPVWEEAFYRGHLRRRQYWLDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR97</accession>
    <name>A0A1D8PR97_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose-induced degradation complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C703240WA</name>
        <name evidence="5" type="ordered locus">orf19.12596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716954.2">
        <property type="nucleotide sequence ID" value="XM_711861.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR97"/>
    <dbReference type="FunCoup" id="A0A1D8PR97">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PR97"/>
    <dbReference type="GeneID" id="3641368"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703240WA"/>
    <dbReference type="CGD" id="CAL0000176928">
        <property type="gene designation" value="orf19.12596"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03240W_A"/>
    <dbReference type="eggNOG" id="KOG0293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PR97"/>
    <dbReference type="OMA" id="DYGKLWC"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000176928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="720" mass="82146" checksum="3CFBE1D7E4E7D313" modified="2017-01-18" version="1">MTLDELKLQLIVKSLHELGCDQLATELISQLRQTNSLDQQPGDELHNWILEQLRIRNYTELDDYFCSLLNDTNGLNEFVKIINYRGDNMDSIISILLYLIRRANYLDVIKLSDSLTDTERLTYVNNKLLPLLDCVDVGNNKIEDISSVIDVRILQQLSKEKESKLLMDSNHAIEQYLFQLPIDSIHSLNQFIFDKLFNGSIFNLLTTDSLANTPDLATIIQQAAKYQQSQSPFYLPPRTKQERKKAPLPLPSKRFHDNFNGNTTTLLHTLTYHKDEVWFVKFSPSGKFLVTGSLDGRLVLYDVLNNFQLIKVLEPTMAADNTAFSPISTRPTSSKNNKAVIYCCWDPKEQYIVSCCLDTVIRVWSVGDIHKRRITRSETNTITDYKLITCFTLAPDIKTWTCEFLPENRKLSGDLSGQSDSPQFIVGSPDKVLKIFDCNGIELFDFYGNIEDEDERENEQSNQNQDDHLALKPNLQQQQQPSLASSTSTSSQSHGQTTSTTAEEANKHDDISMKDTDESLPRVRTYKTSLESNFNRINDLVITNNGKILITLNDHQLHFYTVPDTLGEEATTRRICNIHFKGRLTSCSISHNGKYLLISSAPEELQVWDLSPLLVNESNRPILYRKYLGHTQSSYIVRSTLGYLNEDNDQEELVLTGSDHGYIYFWKFTTGQLITRIKGHVGLCNGVDWNRNGMVIKGKDYGKIWASVGDDKLVKIWGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRG4</accession>
    <name>A0A1D8PRG4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mam33p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">MAM33</name>
        <name evidence="2" type="ordered locus">CAALFM_C703930CA</name>
        <name evidence="1" type="ordered locus">orf19.7187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715236.1">
        <property type="nucleotide sequence ID" value="XM_710143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRG4"/>
    <dbReference type="SMR" id="A0A1D8PRG4"/>
    <dbReference type="FunCoup" id="A0A1D8PRG4">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRG4"/>
    <dbReference type="GeneID" id="3643103"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703930CA"/>
    <dbReference type="CGD" id="CAL0000193007">
        <property type="gene designation" value="MAM33"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03930C_A"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRG4"/>
    <dbReference type="OMA" id="CEYMMSK"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000020">
        <property type="entry name" value="Mitochondrial matrix acidic protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
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    </dbReference>
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        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000193007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="264" mass="29883" checksum="2A632C7289F18949" modified="2017-01-18" version="1">MSRLLSTTLRSQLSKRLVASVSRPSKTVLATLPKAIATTSLRSFHNTPITFNQTAESDLKQILDKELQVVEAIPNELDQSHVDFLETSGFKVVSKPGNANVELVKKDEQGHIIHVYFDVEDVTDIPAEELELEGQELEEEAESLDQIFSNVKVLIENPTKNEGLFFSLMLQASESAFLVDYVNTQADVQKFISKIDNEGEFADKFNYQGPKFGLLDESLQVEFENYLVSKGIDEQLADFIIGYSDVKEETEYRNWLNSVNKFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRI7</accession>
    <name>A0A1D8PRI7_CANAL</name>
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        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
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    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C703980WA</name>
        <name evidence="11" type="ordered locus">orf19.7183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_710139.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="CGD" id="CAL0000180939">
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG3318">
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </feature>
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        </location>
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            <end position="44"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SYF2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_04290W_A"/>
    <dbReference type="eggNOG" id="KOG2609">
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        <property type="component" value="Chromosome 7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
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        <property type="entry name" value="SYF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0747">Spliceosome</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000182244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="132" mass="15525" checksum="5597F72A95A90A4E" modified="2017-01-18" version="1">MSRLEKLKEKRREGQKPQQERKSVKTTPSEPRSHMDYTIEETENWHKKQRVDGSENVDKLAESTYYKDISAIKVDLQAYREGKAADPTELTTILAANTERKTKRKRHAKDADADSYINEKNKQFNMKLNRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRP3</accession>
    <name>A0A1D8PRP3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mms22p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">MMS22</name>
        <name evidence="3" type="ordered locus">CAALFM_CR00390WA</name>
        <name evidence="2" type="ordered locus">orf19.7494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718651.1">
        <property type="nucleotide sequence ID" value="XM_713558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRP3"/>
    <dbReference type="STRING" id="237561.A0A1D8PRP3"/>
    <dbReference type="GeneID" id="3639681"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00390WA"/>
    <dbReference type="CGD" id="CAL0000177845">
        <property type="gene designation" value="MMS22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00390W_A"/>
    <dbReference type="eggNOG" id="ENOG502SF90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRP3"/>
    <dbReference type="OMA" id="YINHMLA"/>
    <dbReference type="OrthoDB" id="4018542at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000177845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1704" mass="196922" checksum="1ACAD5983CD97A91" modified="2017-01-18" version="1">MSNTEYISDSEDDSLRGELLVDKNKFTNILSTLSPSKQELTRQRLETLTNISYVNIENSTCSPRLGHNQNSETRNTINNLIEDSDDDSDSNPIDLIKNLPRRSANEIEQREHSTSQHQSQDNAITQNIVGNTVVPEDQENENHLQSYLNTTNSYVTWSGRSLRKRNFASTHPYLADQAHYLGLSDIDYLNEIYEENDHNLEKVVKYLNYNYERLKKRYPKDEKFRSKNFYTIISRQSHLASEKELQEEQRNGDSGSLPNIDEEFEDEDEEGNKEFTIDPLDDLNSQTYETDESSHEPDDFLQPVKHHRLVIPDDDDEDDNFDTNSNFYSRNVANEESGSGSDSDSSKSDVYVRVGGRFRKERNALKGVLPESAKRLSIYQPKSKGPSSRHLQKPHPVSEHRKGIALRKRTKRKISERDDFTGFVDDTITYDTNNELYHELYDQPIVIEEPTPALNYPSFESVTNFSESSASEDEGEQMNYESDLDIFDVGPPQADITGVDEETGKLDENGDLDEPSDYEVREGDYINHMLATAPKRKTTAPKRQSASATTMGTSGNRTYKSQNRSIDGMLSRPKKAHSYNTKRDVRRSDSSTVSVINRSTPNSRRQRKPRTARAASDESYSRLPVKRITSLRDQNTHKTTRPTRKSKKRKDNLQLTTLDNCMKGNPKDLFTDNYLFSRSPILSTTIVEAASVTRFVKESYKNVNPSAPQMAPSIILGSQPIFEFGCILNDIVLDKITALGDGKFYQIHKDSVTIEFLGETVILTLIDLESSKFRYEKLLIHLARLSKNSDLSNESLIQTVYTTVKGILEWNLILQECPTERIWKLIHLAVSNIRDSPYLTASTMKFILPYFILVEYTMSMITKLNNKPSSFDSNPLGIRYWQLFFETFSGDLFEKSNFEAGAKTKEAESYFILCRILEESGVWWTTIIKALQVYEAFDLSLLLESVFCLCVFARKGFSWEPLQLVYQKAILEETLGVEFYYRYLEIVYFMNQRNNWPLPETVVLQIYSSITRMKFANFIDEIGMPDLIGKVSNRFDIPDDSFFERFMQLLYWYISGLSEPSKVKKLVTKLFTFSKFQYVNDQSHHVMFINRLNFILLLASVCKVDLKTQLLNLLEGIENAKDAKLIKLASQGVCVLTEIAIQRDTKLPIEGISIVIQCCINGYYNVHGILKVWKNFLISLKDLFRDPLSRLSHSLQLLNISKSIDINNVPDKIIIDICHVLSHITSSMINVKDMVIQKHIKTIKSFNEFVLSLLHRQMGRLPLPSVIQENRVCDLIEILLSIWVQCAFVLDESWDRLILQTYAYTGNQQSREQFALYFYSKILQFNNLKGCKELVTRQVLRDLVCFNPSKYLCSILQKLQKEKWGTFNFGKTNGITLSMITNSRYVVVTNILQNLASDSSIISMYEYQLYVKDILRTLDIEFEKYYSSLRYKTFCVNVIKDIQKYCEPAIINESLLTNLASKLGISENELSHLKIQKLPLKEKLKAFVGEFLNAVYFGGDYIKILEKFTFEEGVELIYHLVSVLLQEMQANSDFITWKVIYLLLKFFDENLRLFKFKFVNFQFKRFLKQLVELPKVRQRSSSTADQYCRICCLLCITSILRYCKIIFEGYTDLNEIECYWVLFSNAVHSYNADKSKFSEYVYSSFRMQDLLNDFRFPKDPNPQDDISQESLQVAHRVLVSEIDLIDTTSGEVPDTCILDYDYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRX4</accession>
    <name>A0A1D8PRX4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fth2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">FTH2</name>
        <name evidence="10" type="ordered locus">CAALFM_CR01270CA</name>
        <name evidence="9" type="ordered locus">orf19.10737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717918.2">
        <property type="nucleotide sequence ID" value="XM_712825.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRX4"/>
    <dbReference type="STRING" id="237561.A0A1D8PRX4"/>
    <dbReference type="GeneID" id="3640401"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01270CA"/>
    <dbReference type="CGD" id="CAL0000181829">
        <property type="gene designation" value="FTH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01270C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQ3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRX4"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="PHI-base" id="PHI:11356"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF7">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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    <reference evidence="3 4" key="2">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Martchenko M."/>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000187239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="133" mass="15420" checksum="BC74DA9A470A9655" modified="2017-01-18" version="1">MKVEIVEWKSYCTWHWDLASSDGYVDELCGICRVSYDGTCPNCKYPGDQCPIVLGSGCTHNFHLHCILKWLEQETSKGLCPMCRQIFTFKEQKKQTPEEVAKLKKLIDGHKVMRERPEQADQEFEEYVPETIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PUA2</accession>
    <name>A0A1D8PUA2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <shortName evidence="11">CK II alpha</shortName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">CKA1</name>
        <name evidence="14" type="ordered locus">CAALFM_CR10660WA</name>
        <name evidence="13" type="ordered locus">orf19.7652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2019-03" db="PDB data bank">
            <title>Crystal structure of Cka1p, a casein kinase 2 alpha ortholog from Candida albicans.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH AMP</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Phosphorylates YTA7 during S-phase to promote transcription of histones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719411.2">
        <property type="nucleotide sequence ID" value="XM_714318.2"/>
    </dbReference>
    <dbReference type="PDB" id="6O6Q">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B=1-335"/>
    </dbReference>
    <dbReference type="PDBsum" id="6O6Q"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PUA2"/>
    <dbReference type="SMR" id="A0A1D8PUA2"/>
    <dbReference type="FunCoup" id="A0A1D8PUA2">
        <property type="interactions" value="1090"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PUA2"/>
    <dbReference type="GeneID" id="3639018"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10660WA"/>
    <dbReference type="CGD" id="CAL0000178518">
        <property type="gene designation" value="CKA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10660W_A"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PUA2"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000178518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW31714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6O6Q"/>
        </source>
    </evidence>
    <sequence length="335" mass="39961" checksum="BCB9288BF99CB303" modified="2017-01-18" version="1">MSSHRHNTVQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYFDPIRVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PUA5</accession>
    <name>A0A1D8PUA5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_CR10770WA</name>
        <name evidence="9" type="ordered locus">orf19.7666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719425.1">
        <property type="nucleotide sequence ID" value="XM_714332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PUA5"/>
    <dbReference type="GeneID" id="3638944"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10770WA"/>
    <dbReference type="CGD" id="CAL0000177995">
        <property type="gene designation" value="orf19.7666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10770W_A"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PUA5"/>
    <dbReference type="OMA" id="SWHIWAL"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000177995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59790" checksum="5B73D3347961DE5E" modified="2017-01-18" version="1">MVNHKNSGGLATKDNVSITQDEISHDEISQSDTPYIDISLDIDEEEVQRRNNSKWFQVKKFWWDGTGKHPKEQQYLMKLDFFLLTSSCLGYFIKNLNQTNVTTAFVNGMDEYYGMNKNQYNYLLTMFTIGYIIGQIPSNMLLHKISIRYYLGGLEIFWAFLTLIMITVPSHKIKALYALRFLSGFTESAYFPCLEYILGAHYSKDEVSKRSAWFAISGNLSGIVSGPLQQAIIKRFSKSGMPPFKWMFVFDAVISFPIGIYTVFANPNTPSTTNSWYFTEDDKKVGLERRRLIGAEINTKTNYSWKKVKSFFNTWHIYVFPIVFLCYNNSCAAIGQPTFQTWLKLTLKKPSSVYNSYPSIISGVGIAMALLFAYLNDYLGGRKNVWFVSGFFVPLIIGCALLAKWNIPIGLHYLCYFLVGVPTSWGQPFIFSWINRLLYHNDMKRNFVVVVTNTLPYVTGAFVPIFVWNTNDKPEYFIGFSYTAALSALGLVATFVAHYLTIQDENGVTLKDLESYGSTEFSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G1UBC2</accession>
    <accession>A0A1D8PID9</accession>
    <accession>G1UB13</accession>
    <name>PGA47_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cell wall adhesin EAP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Enhanced adherence to polystyrene protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GPI-anchored protein 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EAP1</name>
        <name type="synonym">PGA47</name>
        <name type="ordered locus">CAALFM_C209530WA</name>
        <name type="ORF">CaO19.1401</name>
        <name type="ORF">CaO19.8979</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Eukaryot. Cell" volume="2" first="1266" last="1273">
            <title>EAP1, a Candida albicans gene involved in binding human epithelial cells.</title>
            <authorList>
                <person name="Li F."/>
                <person name="Palecek S.P."/>
            </authorList>
            <dbReference type="PubMed" id="14665461"/>
            <dbReference type="DOI" id="10.1128/EC.2.6.1266-1273.2003"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="1451" last="1469">
            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
            <authorList>
                <person name="Lan C.Y."/>
                <person name="Rodarte G."/>
                <person name="Murillo L.A."/>
                <person name="Jones T."/>
                <person name="Davis R.W."/>
                <person name="Dungan J."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="15387822"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Biotechnol. Prog." volume="21" first="1601" last="1609">
            <title>Identification of Candida albicans genes that induce Saccharomyces cerevisiae cell adhesion and morphogenesis.</title>
            <authorList>
                <person name="Li F."/>
                <person name="Palecek S.P."/>
            </authorList>
            <dbReference type="PubMed" id="16321041"/>
            <dbReference type="DOI" id="10.1021/bp050236c"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Microbiology" volume="154" first="1193" last="1203">
            <title>Distinct domains of the Candida albicans adhesin Eap1p mediate cell-cell and cell-substrate interactions.</title>
            <authorList>
                <person name="Li F."/>
                <person name="Palecek S.P."/>
            </authorList>
            <dbReference type="PubMed" id="18375812"/>
            <dbReference type="DOI" id="10.1099/mic.0.2007/013789-0"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2007" name="Eukaryot. Cell" volume="6" first="931" last="939">
            <title>Eap1p, an adhesin that mediates Candida albicans biofilm formation in vitro and in vivo.</title>
            <authorList>
                <person name="Li F."/>
                <person name="Svarovsky M.J."/>
                <person name="Karlsson A.J."/>
                <person name="Wagner J.P."/>
                <person name="Marchillo K."/>
                <person name="Oshel P."/>
                <person name="Andes D."/>
                <person name="Palecek S.P."/>
            </authorList>
            <dbReference type="PubMed" id="17416898"/>
            <dbReference type="DOI" id="10.1128/EC.00049-07"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>GPI-ANCHOR</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2009" name="PLoS Pathog." volume="5" first="E1000601" last="E1000601">
            <title>Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans.</title>
            <authorList>
                <person name="Sahni N."/>
                <person name="Yi S."/>
                <person name="Daniels K.J."/>
                <person name="Srikantha T."/>
                <person name="Pujol C."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19798425"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000601"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2010" name="Eukaryot. Cell" volume="9" first="1622" last="1634">
            <title>Heterologous expression of Candida albicans cell wall-associated adhesins in Saccharomyces cerevisiae Reveals differential specificities in adherence and biofilm formation and in binding oral Streptococcus gordonii.</title>
            <authorList>
                <person name="Nobbs A.H."/>
                <person name="Vickerman M.M."/>
                <person name="Jenkinson H.F."/>
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            <dbReference type="PubMed" id="20709785"/>
            <dbReference type="DOI" id="10.1128/EC.00103-10"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2011" name="J. Med. Microbiol." volume="60" first="1261" last="1269">
            <title>Detailed comparison of Candida albicans and Candida glabrata biofilms under different conditions and their susceptibility to caspofungin and anidulafungin.</title>
            <authorList>
                <person name="Kucharikova S."/>
                <person name="Tournu H."/>
                <person name="Lagrou K."/>
                <person name="Van Dijck P."/>
                <person name="Bujdakova H."/>
            </authorList>
            <dbReference type="PubMed" id="21566087"/>
            <dbReference type="DOI" id="10.1099/jmm.0.032037-0"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Microb. Pathog." volume="64" first="33" last="38">
            <title>BDSF inhibits Candida albicans adherence to urinary catheters.</title>
            <authorList>
                <person name="Tian J."/>
                <person name="Weng L.X."/>
                <person name="Zhang Y.Q."/>
                <person name="Wang L.H."/>
            </authorList>
            <dbReference type="PubMed" id="23948468"/>
            <dbReference type="DOI" id="10.1016/j.micpath.2013.07.003"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Eukaryot. Cell" volume="12" first="875" last="888">
            <title>Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/alpha biofilms.</title>
            <authorList>
                <person name="Srikantha T."/>
                <person name="Daniels K.J."/>
                <person name="Pujol C."/>
                <person name="Kim E."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="23563485"/>
            <dbReference type="DOI" id="10.1128/EC.00071-13"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E62902" last="E62902">
            <title>Human serum promotes Candida albicans biofilm growth and virulence gene expression on silicone biomaterial.</title>
            <authorList>
                <person name="Samaranayake Y.H."/>
                <person name="Cheung B.P."/>
                <person name="Yau J.Y."/>
                <person name="Yeung S.K."/>
                <person name="Samaranayake L.P."/>
            </authorList>
            <dbReference type="PubMed" id="23704884"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0062902"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5 6 7 9">Cell wall protein which mediates cell-cell and cell-substrate adhesion. Required for biofilm formation and plays a role in virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Secreted</location>
            <location evidence="6 7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Lipid-anchor</topology>
            <topology evidence="14">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 6 8 10 11 12 13">Expressed in white cells. Transcription is regulated by the transcription factor EFG1 and up-regulated by alpha-pheromone, by host serum, in biofilms, and in high iron conditions. Repressed by BCR1 in a/a biofilms.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain mediates haploid invasive growth and yeast cell-cell adhesion.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The regions containing tandem repeats are required to project the N-terminal region into the extracellular environment and to mediate adhesion to polystyrene and to host cells. In allele CaO19.8979, the N-terminal tandem repeat region is expended and contains up to 90 repeats and the C-terminal tandem repeat region has one more repeat.</text>
    </comment>
    <comment type="PTM">
        <text>The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the PGA18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_709479.2"/>
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        <property type="glycosylation" value="1 site, No reported glycans"/>
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        <property type="protein sequence ID" value="C2_09530W_A-T-p1"/>
        <property type="gene ID" value="C2_09530W_A"/>
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        <property type="gene designation" value="EAP1"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="P:single-species biofilm formation in or on host organism"/>
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        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
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        <property type="project" value="CGD"/>
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        <property type="entry name" value="Flocculin_t3_rpt"/>
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        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
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        <property type="entry name" value="Flocculin_t3"/>
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    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="chain" id="PRO_0000424809" description="Cell wall adhesin EAP1">
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            <begin position="19"/>
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    <sequence length="653" mass="65265" checksum="62847FE0F3135DC1" modified="2017-03-15" version="2" precursor="true">MKVSQILPLAGAISVASGFWIPDFSNKQNSNSYPGQYKGKGGYQDDCGDDYKKGYKSKTYSKVKPITSTDCTTPIQPTGTTTGYTKDVVESTSYTTDTAYTTTVITVTKCDGGSCSHTAVTTGVTIITVTTNDVITEYTTYCPLTSTPATESTPATESTPATESTPATESTPATESTPATESTPCTTSTETTPATESTPATESTPATESTPATESTPATESTPATESTPATESTPATESTPCTTSTETTPATESTASTETASSTPVESTVIVPSTTVITVSSCYEDKCSVSSVTTGVVTISSEETIYTTYCPITSSITIPVPNTSTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPVESQPATTPVAPGTETTPAAPGTPVESQPVIPGTETTPAAPGTPGTEATPVTTQPVSVLSTSQVVTASGEFSTVTAHSTSIVASCPEGGCVPEGQQTETSPSVPTNGPEVEASSSVLSIPVSSVTTSTIASSSETSVPPAQVSTFEGSGSALKKPYYGLAVAALVYFM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-14" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>O93852</accession>
    <accession>A0A1D8PU25</accession>
    <accession>Q5ACU1</accession>
    <name>ALO1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="6">ALO</shortName>
            <ecNumber evidence="5">1.1.3.37</ecNumber>
            <ecNumber evidence="5">1.1.3.8</ecNumber>
            <ecNumber evidence="5">1.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">FAD-linked oxidoreductase ALO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ALO1</name>
        <name evidence="6" type="synonym">ALO</name>
        <name type="ordered locus">CAALFM_CR09790WA</name>
        <name type="ORF">CaO19.7551</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Infect. Immun." volume="69" first="3939" last="3946">
            <title>Deficiency of D-erythroascorbic acid attenuates hyphal growth and virulence of Candida albicans.</title>
            <authorList>
                <person name="Huh W.-K."/>
                <person name="Kim S.-T."/>
                <person name="Kim H."/>
                <person name="Jeong G."/>
                <person name="Kang S.-O."/>
            </authorList>
            <dbReference type="PubMed" id="11349062"/>
            <dbReference type="DOI" id="10.1128/IAI.69.6.3939-3946.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="Eur. J. Biochem." volume="225" first="1073" last="1079">
            <title>Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231.</title>
            <authorList>
                <person name="Huh W.K."/>
                <person name="Kim S.T."/>
                <person name="Yang K.S."/>
                <person name="Seok Y.J."/>
                <person name="Hah Y.C."/>
                <person name="Kang S.O."/>
            </authorList>
            <dbReference type="PubMed" id="7957197"/>
            <dbReference type="DOI" id="10.1111/j.1432-1033.1994.1073b.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">D-arabinono-1,4-lactone oxidase that catalyzes the final step of biosynthesis of D-erythroascorbic acid, an important antioxidant and one of the virulence factors enhancing the pathogenicity (PubMed:11349062, PubMed:7957197). Is also able to oxidize L-galactono-1,4-lactone, L-xylono-1,4-lactone and L-gulono-1,4-lactone (PubMed:7957197).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:23757"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20617"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17464"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="EC" id="1.3.3.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:20619"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32363"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17587"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="EC" id="1.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:32364"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-xylono-1,4-lactone + O2 = dehydro-L-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18118"/>
            <dbReference type="ChEBI" id="CHEBI:177361"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:68361"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Abolishes D-arabinono-1,4-lactone oxidase activity and impairs the production of D-erythroascorbic acid (PubMed:11349062). Leads to increased sensitivity towards oxidative stress, defective hyphal growth and attenuated virulence (PubMed:11349062).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="5"/>
    <dbReference type="EC" id="1.1.3.8" evidence="5"/>
    <dbReference type="EC" id="1.3.3.12" evidence="5"/>
    <dbReference type="EMBL" id="AF031228">
        <property type="protein sequence ID" value="AAC98913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719313.1">
        <property type="nucleotide sequence ID" value="XM_714220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O93852"/>
    <dbReference type="SMR" id="O93852"/>
    <dbReference type="BioGRID" id="1222077">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="O93852">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="237561.O93852"/>
    <dbReference type="EnsemblFungi" id="CR_09790W_A-T">
        <property type="protein sequence ID" value="CR_09790W_A-T-p1"/>
        <property type="gene ID" value="CR_09790W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638983"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09790WA"/>
    <dbReference type="CGD" id="CAL0000174500">
        <property type="gene designation" value="ALO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09790W_A"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_1_1"/>
    <dbReference type="InParanoid" id="O93852"/>
    <dbReference type="OMA" id="YPRFGEF"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:197"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050024">
        <property type="term" value="F:L-galactonolactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050105">
        <property type="term" value="F:L-gulonolactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000042">
        <property type="entry name" value="D-arabinono-1,4-lactone oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000128164" description="D-arabinono-1,4-lactone oxidase">
        <location>
            <begin position="1"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="543"/>
            <end position="546"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pros-8alpha-FAD histidine" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9FUJ1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11349062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="7957197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="11349062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="557" mass="63447" checksum="0348233954111D92" modified="1999-05-01" version="1">MTDIPESLKPFVTKKVIHSTWAGTFLCKPQAIFQPRNVEEIQELIKQARLHGKTIMTVGSGHSPSDLTMTTEWLCNLDKFNHVLLEEPYYAPKSPTDDTPEIKFVDLTVEAGTRIFELNEYLKRNNLAIQNLGSISDQSIAGLISTGTHGSTQYHGLVSQQVVSVKFLNSAGELITCSSVDKPEYFRAILLSLGKIGIITHVTLRTCPKYTIKSKQEIINFETLLNNWDNLWLESEFIRIWWFPYTNKCVLWRANKSTDPLSDPRPSWYGTKLGRFFYESLLWVSVHLFPRLTPFVEKFVFGQQYGEVETLGKGDIAVQNSVEGLNMDCLFSQFVNEWSSPLNSGPEILTELKKIITDASQTGDFFVHAPIEVRCSNVTYSDEPFTDDKNQKSLYPSQEWLSNRSKTSAGPIPGNNLRPYLDNSPKLPYSKDGKITNDQLTLFINATMYRPFGTNVETHKWFQLFEDVMSKAGGKPHWAKNFIGLTQDEKYDKQQDLKTQLEFGGKPFYTMLGFKPVMQDWFGKDLVAFNKVRKETDPDGVFLSGKVWAERNGILLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-03-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>P0CU34</accession>
    <accession>A0A1D8PKI8</accession>
    <name>TSA1B_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Peroxiredoxin TSA1-B</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Thiol-specific antioxidant protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin TSA1-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSA1B</name>
        <name type="ordered locus">CAALFM_C306330WA</name>
        <name type="ORF">orf19.7398.1</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="57" first="1318" last="1341">
            <title>The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis in Candida albicans.</title>
            <authorList>
                <person name="Urban C."/>
                <person name="Xiong X."/>
                <person name="Sohn K."/>
                <person name="Schroppel K."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="16102003"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04771.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Yeast" volume="22" first="907" last="918">
            <title>Characterization of thiol-specific antioxidant 1 (TSA1) of Candida albicans.</title>
            <authorList>
                <person name="Shin D.H."/>
                <person name="Jung S."/>
                <person name="Park S.J."/>
                <person name="Kim Y.J."/>
                <person name="Ahn J.M."/>
                <person name="Kim W."/>
                <person name="Choi W."/>
            </authorList>
            <dbReference type="PubMed" id="16134099"/>
            <dbReference type="DOI" id="10.1002/yea.1283"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Localizes to the cell surface in hyphally grown cells, whereas no surface but mainly nuclear localization is found in yeast-form cells.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Induced by oxidative stress.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Results in delayed hyphal development and enhanced sensitivity to cell wall-perturbing agents, yet does not impair virulence in vivo.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330878.1">
        <property type="nucleotide sequence ID" value="XM_019475333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CU34"/>
    <dbReference type="SMR" id="P0CU34"/>
    <dbReference type="FunCoup" id="P0CU34">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P0CU34"/>
    <dbReference type="EnsemblFungi" id="C3_06180C_A-T">
        <property type="protein sequence ID" value="C3_06180C_A-T-p1"/>
        <property type="gene ID" value="C3_06180C_A"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_06330W_A-T">
        <property type="protein sequence ID" value="C3_06330W_A-T-p1"/>
        <property type="gene ID" value="C3_06330W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515214"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306180CA"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306330WA"/>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06180C_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06330W_A"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="P0CU34"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0049">Antioxidant</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000439054" description="Peroxiredoxin TSA1-B">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-169); in linked form" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-48); in linked form" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P34760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16102003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16134099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="16102003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="196" mass="21860" checksum="0BD7B6B4715DCDBB" modified="2017-03-15" version="1">MAPVVQQPAPSFKKTAVVDGVFEEVTLEQYKGKWVLLAFIPLAFTFVCPSEIIAYSEAVKKFAEKDAQVLFASTDSEYTWLAWTNVARKDGGIGKVDFPVLADTNHSLSRDYGVLIEEEGVALRGIFLIDPKGVLRQITINDLPVGRSVEESLRLLEAFQFTEKYGEVCPANWHPGDETIKPSPEASKEYFNKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KV5</accession>
    <name>Q59KV5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">AMO2</name>
        <name evidence="14" type="ordered locus">CAALFM_C206700WA</name>
        <name evidence="13" type="ordered locus">orf19.10662</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710377.1">
        <property type="nucleotide sequence ID" value="XM_705285.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KV5"/>
    <dbReference type="SMR" id="Q59KV5"/>
    <dbReference type="STRING" id="237561.Q59KV5"/>
    <dbReference type="GeneID" id="3648021"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206700WA"/>
    <dbReference type="CGD" id="CAL0000179644">
        <property type="gene designation" value="AMO2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06700W_A"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="Q59KV5"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="245"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000179644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW27671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="671" mass="76016" checksum="EADA000FB43097BA" modified="2005-04-26" version="1">MSSSSSSSSSTIHPFHPVKDYEIRLASKLVKDAYPASANVHFVQIDRVDPPKKDMKQYIVAEREGLPLPKIPRILYLYYYTNTMEFNKALVNVTIGHIITKTQLPKGVIGPLLPDDMMEWEEYCNNHPAVKAEIAKLKLPSGYSVRNDPWIYATDDANETRPLIQFYMYVLAGNGHSESNHYSLPLKFSPVFECFTKKFIRIDYLPGGFDHKTVPTGPWQEVPCVQYHPDLNGETQMRDVKPLLISQPEGPSFQIIDGNKVLWQGWEFRVSPNSREGFAIYDCWFKGRQTFYRISLSEMTVPYGDPRAPYHRKQAFDLGDCGFGVNGNKLALGCDCLGVIKYLDGHGIHANGEPFVIPNTVCMHEQDDGLLYKHVNYRTDNAVVARKRIFIVQTIATVANYEYIINLKFVTDGSIDIEVRATGILSTMPIDENVKVPWGTIVGPNVMAAYHQHILGFRIDPAVDGHMNSVVYDDAIKLPRDEFNPYGIGFVTDRHFVEKAGYIEQRPFDNRTYKIINENVINPISKTPVGYKINMPARQMLLADPDSFNAKRAKFATQQVWVTKYQDHQLFAAGEFTNQSKIDTGITEWANGIDPVRNEDIVVWATMGFTHIPRVEDFPVMPVETHNIQLAPANFFDRNPALDLPQSNNGFNKSVLVADNSDEKACCKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q59M47</accession>
    <name>Q59M47_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR05500CA</name>
        <name evidence="1" type="ordered locus">orf19.13274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710807.1">
        <property type="nucleotide sequence ID" value="XM_705715.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59M47"/>
    <dbReference type="GeneID" id="3647598"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05500CA"/>
    <dbReference type="CGD" id="CAL0000195695">
        <property type="gene designation" value="orf19.13274"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05500C_A"/>
    <dbReference type="eggNOG" id="ENOG502SY6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363686_0_0_1"/>
    <dbReference type="InParanoid" id="Q59M47"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000195695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="101194" checksum="ED27026D3D48F852" modified="2005-04-26" version="1">MAETYQSTLYSELFNDSIDNDDDFYKSIFVTPIAKDLLTTVLNTNTEAIVLTSEVSDKNLLILSRIYFSGLKVLAQATNYHPSDVTKLSNEKVKSIVGISKQNRTVSSEKLFDDESGDITELNGNVSKNTSKQTLNEFDDGDDLTTLSGGRQGWQDSLSNNPGFPLKDENAFSNLSEKDRIDLIGNVLKIFQVWFQNLIDVDFKLEVSQRSSGIQLKLRVFEFCGENSNGSFLIELFTILKSFLATAIKEIEDTDSESKFISLSAIKESINLLKKVFTSIFLDLDMHKKGDNEFKSLVKLLSVFFEVDFADEFWKLIKLTSPDLEDNNYKPPKIVLSLETMSTFYLLMGVLANTPSSLFSEGKRNADITTFSVEMKNPYKSYFSQDFKWDVFNQQVNSKLLPLFCVEFNYCYNFRPDLVLEQIQNSSLINWISGNRLSSDIYVNCLTSQTITNLEVNKKLSVAGSKSDLYCQELNKIYNSKIQNLQAKQSNEEMNLDLSKIFPVFLHMYTFAQNSSFNSILTTQQYHFYDKIDDRTDDELNNVELFEVWVCLLSYVFEYQYRSTLMQDLTQLALSTLLTLPLNNLVDYQINEYKWKLCHQKVPFVPLDLGAKGHKPSIFYILDTVQNLLRFNLTNRLHVVNLSMGLNLMYNILDHVKADSNIELDKYSWDNLFLSLFGLIKFIKKQNSLILKYINQRDLGSLTEECFLVLNLLLDTRFSSVKQVIVQEKSSFMGLFDSDETRSINYALIYNILLNFEVIQTLINEFGLSESEHLTNLFHCMEHFDKLFYLTEDSKKERLYKKTEVLDFDFDSPVFVAAINSFTDAKNSNQTENSTEGTQSPITYQYNQTLKYSLKQKQRAVLDDQAMFSLIHRTFFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59M50</accession>
    <name>Q59M50_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cwt1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">CWT1</name>
        <name evidence="11" type="ordered locus">CAALFM_CR05530CA</name>
        <name evidence="10" type="ordered locus">orf19.13271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710804.1">
        <property type="nucleotide sequence ID" value="XM_705712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59M50"/>
    <dbReference type="FunCoup" id="Q59M50">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59M50"/>
    <dbReference type="GeneID" id="3647595"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05530CA"/>
    <dbReference type="CGD" id="CAL0000195956">
        <property type="gene designation" value="CWT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05530C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_0_1_1"/>
    <dbReference type="InParanoid" id="Q59M50"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="PHI-base" id="PHI:2562"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036171">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000195956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="578" mass="64670" checksum="BFAF033A0EBBA385" modified="2005-04-26" version="1">MSTMSTQKANSSTPGETDSSSSLPPPEITEPTYKKPEKSTKRRKKKLEIACVYCRRSHMICDESRPCQRCIKRGIAHLCYDEPSNSRQRKKAAALRKTQSEGAPMVTSPITLPLTGSTGNQSPLPLPPLQASQSDIRSAPKTENSLQFSQPALHQQQMQENPQGASQSVHTNNTHIYSSQNQQQQPQHQQQLQQQQPQPQPQSRLIKNSVLSQTLPYNQQPFFYSEHANSEFSSLNDFLSMIDDPELVNGALNDDTDGLLNFGVGNNNNSGGSNSNINNTHNNNNNGFSISGGNSTTNLNAVLAYSPNSNLFPPTFGNEADSTQIQSQQQQPELTQQPPALNPVKVEPQAEKTEQQPVISDSARDKFFLTAADPTTEISPEERLKQVIKAKLEAGLLQPYNYAKGYARLQRYMDNYMNISSRQRILKPLSIFRPAFRAIARTLKDVDLVLVEESFERMLLDYDRVFTAMAIPACLWRRTGEIYRGNKEFASLVGVTTDDLKDGKLAIYELMSEESAVNFWEKYGAIAFDKGQKAVLTSCNLRTRDGIKRKSCCFSFTIRRDRYNIPSCIVGNFIPIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MZ5</accession>
    <name>Q59MZ5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">ADE6</name>
        <name evidence="23" type="ordered locus">CAALFM_CR04740CA</name>
        <name evidence="22" type="ordered locus">orf19.13694</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711102.1">
        <property type="nucleotide sequence ID" value="XM_706010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MZ5"/>
    <dbReference type="SMR" id="Q59MZ5"/>
    <dbReference type="FunCoup" id="Q59MZ5">
        <property type="interactions" value="1000"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MZ5"/>
    <dbReference type="GeneID" id="3647304"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04740CA"/>
    <dbReference type="CGD" id="CAL0000175495">
        <property type="gene designation" value="ADE6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04740C_A"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="InParanoid" id="Q59MZ5"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="42"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="488"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="707"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="895"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0000175495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AOW31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1370" mass="150809" checksum="5E35E22145D9C9AA" modified="2005-04-26" version="1">MSKFLILSGPKALSDFRINNLIQEIEKKIGQSDIIDKVVGSFTHYISLQQEQGDLTDKQLELLKILLTYDNPLETDNDENSSLNKILIKNSTVIDGESIELPPNTYLIQILPRPGTISPWSSKATDIAQICGLKDQIERIERGLSLLIKTKNGFKLDQNNNNNNNDSGSNSNSIPIETLLTSVFDRMTQSIYFGNNVPQYNDLFAHHSPKPLVTIDIISDSENLIKANKELGLALDQGEIDYLINAFKEIIGRNPTDVELFMFAQVNSEHCRHKIFNADWTIDGTTKELSLFKMIKNTHEKTPQYTISAYSDNAAVFEGHEGYVWTPDFKTKQWKSIKEKVQTLVKVETHNHPTAVSPFAGAATGSGGEIRDEGAVGRGSKSKAGLSGFSVADLNIPTLPQPWERNVGKPNHIASSLDIMLEAPIGSAAFNNEFGRPAINGYFRTLTTEVENSHGETEIRGFHKPIMLAGGMGAIRPDLALKDTKITPGAKLIVLGGQSMLIGLGGGAASSISSGEGSADLDFASVQRGNPEIQRRAQEVINACVSLGKLGNPIQSIHDVGAGGLSNALPELVHDNDLGAKFELRSILSLEPGMSPMEIWCNESQERYVLGVAPENLDLFAKICQRERAPFAVVGVATEEQRLVLTDSLLNSTPIDLEMSVLFGKPPKMSRTAITSNLNLTPFETTNNNLDVSESIDRVLQLPAVGSKNFLITIGDRFITGLVDRDQMVGPWQVPVADVGVTATSLGDTILSTGEAMAMGEKPTLALISASASAKMCVAESLLNIFAADIPSLDHVKLSANWMSAASHEGEGAKLYEAVQAIGMDLCPDLGISIPVGKDSMSMKMKWDDKEVTAPLALTITSFAPVDNTSNTWTPQLQNLDEQQQEETVLVLVDLAASNEAGKSLGGSALAQVYKQVGDSAPTVHSHKILKSFLETLIVLHKQFDILAYHDRSEGGLITTVLEMAFAGRCGLDLNINGKQDVFTELFNEELGAVFQIKFKDYTKFQQIFLDNGIDENFIQIIGKPKFDSKQLIDISFNGTPIYSSTRGHLQQLWSNTSYHIQKLRDNPITSTQEYDAIKDDNDPGISYQLTYQPNEFKKYSSQQPKVAILREQGVNSQQEMAWCFQQAGFDVYDVTMSDILEGRTTLDDFVGIAACGGFSYGDVLGAGAGWAKSVLFHDKARQEFKKFFQDRNDTFAFGACNGCQFLSRIAELIPGTENWPTFEKNLSEQYEARFVMVEIESSPQKNNSIFLKNMKGSKLPIAVAHGEGRAQFKALQEQKDFQLDVIHYVDNYGKITENYPFNPNGSPNGIAGITNSNGRVLAMMPHPERVCRKESNSWYPIEQGKEWGQYGPWIELFKSAREWVGDNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NC4</accession>
    <name>Q59NC4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">low-specificity L-threonine aldolase</fullName>
            <ecNumber evidence="8">4.1.2.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">GLY1</name>
        <name evidence="13" type="ordered locus">CAALFM_C110450WA</name>
        <name evidence="12" type="ordered locus">orf19.8601</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-allo-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:26209"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58585"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:19625"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid degradation; L-threonine degradation via aldolase pathway; acetaldehyde and glycine from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.48" evidence="8"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711204.1">
        <property type="nucleotide sequence ID" value="XM_706112.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NC4"/>
    <dbReference type="SMR" id="Q59NC4"/>
    <dbReference type="FunCoup" id="Q59NC4">
        <property type="interactions" value="1039"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59NC4"/>
    <dbReference type="GeneID" id="3647181"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110450WA"/>
    <dbReference type="CGD" id="CAL0000194550">
        <property type="gene designation" value="GLY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10450W_A"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="InParanoid" id="Q59NC4"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000194550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW26674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="373" mass="41778" checksum="C0F741E6F2DD3187" modified="2005-04-26" version="1">MTADEEETFTTFNEFRSDTFTVPTRAMVEDGFMNATFGDSVYQEDETTLRLESKMCEITGKPAALFCVSGTMSNQIGLRANLVQPPYSILCDYRAHVFLHEAGGLATLSQAMVHPVRPSNGNYLTFEDVLANVTYDDGDIHAAPTKVISLENTLHGIIIPIEEIRKISEFCRENDIRLHLDGARLWNASVATGISIKEYCSYFDSVSLCLSKSLGAPIGSVLVGDEKFIRKANHFKKQSGGGIRQAGIMSAMAIHAIDYNLSKLELSHNYAKQIGDFCQEHGIKLESPVDTSLVFLDLKANKMDPNRLVELGRTKYNVKLMGQRIACHFQLSQESVDNVKKCILECFEYHQKHPHKDDGRNNKKMYSFDAIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NX5</accession>
    <accession>A0A1D8PNR1</accession>
    <name>FGR27_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Filamentous growth regulator 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FGR27</name>
        <name type="ordered locus">CAALFM_C503680WA</name>
        <name type="ORF">CaO19.6680</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="2668" last="2678">
            <title>Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.</title>
            <authorList>
                <person name="Uhl M.A."/>
                <person name="Biery M."/>
                <person name="Craig N."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="12773383"/>
            <dbReference type="DOI" id="10.1093/emboj/cdg256"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 6">Transcription factor involved in yeast cell adherence to silicone substrate, filamentous growth, and biofilm formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Induced during biofilm formation.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29779.1"/>
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        <property type="nucleotide sequence ID" value="XM_706340.1"/>
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        <property type="protein sequence ID" value="C5_03680W_A-T-p1"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Nantel A."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000125">
        <property type="entry name" value="Arginine permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="37"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000175530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="529" mass="59776" checksum="19E2B75BD59FEDB7" modified="2005-04-26" version="1">MNEETHLFTTPSGQQQRSNEHPAHPHANTKRLLTSLHTSMISLGGIIGTGLFIGVRITLLNGPIISLMSYLYISLICFYIIQAVGEMSCYMPLNGSLCQFQFIYISNPIGVMNNFIYWISWSITLALELSLIYNMLKYWQWSWIDNIGETWMIFIIWLILTICNLFPVNNYGNIEFIITIFKIFFMMGWIGISISLVLNNGTGFKYWNKDLIWGIDYIKVIENPVGSKLINILSSLISSCFTFQSIESVAICSGEIIDVHKNLPRAIKYVVSRIVVFYILTLFLLTLMIPCNDPRLVSSGGDDDGSTDDVFASPFLIGLINMGMSSSSFLLGFFNFIILISMVSAANSNIYFGSRCLLSMVEEGYFPVVFGETTKNGVPFNAILLTSSIGLISLLSKFKSIDIFYKLLINLSSTSGLIMWLFISISYLQFRRALAFNSIVYETLAYTAVHKFPMIKLSYITIVSIVTIIIGNGIVNIWEFSWDSFISCYLTSIILIVGSVWLSVIWKQPILKKIEDIDIFTNQSVHAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RB8</accession>
    <name>Q59RB8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ICL1</name>
        <name evidence="16" type="ordered locus">CAALFM_C104500WA</name>
        <name evidence="15" type="ordered locus">orf19.14134</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Also acts on 2-methylisocitrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712232.1">
        <property type="nucleotide sequence ID" value="XM_707139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RB8"/>
    <dbReference type="EMDB" id="EMD-31053"/>
    <dbReference type="SMR" id="Q59RB8"/>
    <dbReference type="FunCoup" id="Q59RB8">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59RB8"/>
    <dbReference type="GeneID" id="3646146"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104500WA"/>
    <dbReference type="CGD" id="CAL0000178151">
        <property type="gene designation" value="ICL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04500W_A"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="Q59RB8"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="PHI-base" id="PHI:477"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000178151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="550" mass="61422" checksum="D5441076423E0AC3" modified="2005-04-26" version="1">MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQADKLFKLLEKHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGITAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIESEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSNQYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTEDQFKESKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T94</accession>
    <name>Q59T94_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAALFM_C101860WA</name>
        <name evidence="18" type="ordered locus">orf19.12012</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712962.1">
        <property type="nucleotide sequence ID" value="XM_707869.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59T94"/>
    <dbReference type="SMR" id="Q59T94"/>
    <dbReference type="FunCoup" id="Q59T94">
        <property type="interactions" value="989"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59T94"/>
    <dbReference type="GeneID" id="3645430"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101860WA"/>
    <dbReference type="CGD" id="CAL0000174383">
        <property type="gene designation" value="orf19.12012"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01860W_A"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_2_0_1"/>
    <dbReference type="InParanoid" id="Q59T94"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000007">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="17">
        <location>
            <begin position="145"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000174383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW25873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="305" mass="34006" checksum="BDF8A1D213DF3EB1" modified="2005-04-26" version="1">MDTKEIRSTVSNLEKAVDDTTILKLLNILNDGVKPSEKLLRETKVGVAVNKFRSHDSAEINGLVKKMIRNWRDAVQAEKNNKKKLAIAAGTGTGTPSSSAISPSSSGSGSTTPKPSESTTPSAARKGPRNPKTDGVNTQLYENDTRNASVSALYTSLAVDRDDSPKHILRIAIEIEAEVYKSEYSKVSDSYRNRLRSFTMNLRNKKNPELRERILSKQILPAAFIKMTPNEMAPEALKKEIEKLHKQNLFDAQGATEKRAVTDRFTCGKCKHKKVSYYQMQTRSADEPLTTFCTCENCGNRWKFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TD3</accession>
    <accession>A0A1D8PH66</accession>
    <accession>Q59TG7</accession>
    <name>MED8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED8</name>
        <name type="ordered locus">CAALFM_C204530WA</name>
        <name type="ORF">CaO19.11973</name>
        <name type="ORF">CaO19.4497</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707830.2"/>
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    <dbReference type="BioGRID" id="1228539">
        <property type="interactions" value="27"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.Q59TD3"/>
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        <property type="gene ID" value="C2_04530W_A"/>
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    <dbReference type="GeneID" id="3645446"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204530WA"/>
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        <property type="gene designation" value="MED8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04530W_A"/>
    <dbReference type="eggNOG" id="ENOG502S8U1">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_108151_0_0_1"/>
    <dbReference type="InParanoid" id="Q59TD3"/>
    <dbReference type="OMA" id="PQWYSLQ"/>
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    <dbReference type="PRO" id="PR:Q59TD3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:core mediator complex"/>
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    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
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    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
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            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="239" mass="27959" checksum="EFDF7C7331CBB019" modified="2005-04-26" version="1">MSQTPFNPNSPSVPTTTSLPSTDFSQIPYDVLESIRNRLNQIRQSLTKLADQINNHNRHPQKIKLPSYSYFQNQFQVLITQLMSITNQLYNNEDLLRNTNVYPTPIFPTSAHENMLTTLLRKKVAPEVDEWINGAKLIMENETKNKLDNQQVEIDILKIDQWVQWCLAKIQDLRDEFQFYGFHTVEELDHMETPQGKQEIKEKKDKEFEREQIELKITAGGQKSLHPNQVLKFMCQGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UE6</accession>
    <name>Q59UE6_CANAL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR03080CA</name>
        <name evidence="1" type="ordered locus">orf19.9956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_708158.2"/>
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    <dbReference type="AlphaFoldDB" id="Q59UE6"/>
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    <dbReference type="STRING" id="237561.Q59UE6"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR03080CA"/>
    <dbReference type="CGD" id="CAL0000183978">
        <property type="gene designation" value="orf19.9956"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_03080C_A"/>
    <dbReference type="eggNOG" id="ENOG502S3TP">
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    <dbReference type="HOGENOM" id="CLU_085417_0_2_1"/>
    <dbReference type="InParanoid" id="Q59UE6"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000183978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="191" mass="21711" checksum="1A963C4D2EA6BD26" modified="2005-04-26" version="1">MSESITITANSIDNPETDVRRNERFHLVPRKRLEALVTTSGLIGAMIGFYDGVKISSLRYLTENAHRMPKTVGGWYFYHKKKNYVMIVAGVKKAITTSFKYGAAVGGFFGLEYLLDISRGNTIDFFNTTTAAFLTSTFYAKYNKLSSMQTRKMIFKGTALGLTLGLIQDYLIHARKGRVWYLDRYTQQKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WC3</accession>
    <name>Q59WC3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C107210CA</name>
        <name evidence="10" type="ordered locus">orf19.11926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713890.1">
        <property type="nucleotide sequence ID" value="XM_708797.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WC3"/>
    <dbReference type="SMR" id="Q59WC3"/>
    <dbReference type="STRING" id="237561.Q59WC3"/>
    <dbReference type="GeneID" id="3644473"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107210CA"/>
    <dbReference type="CGD" id="CAL0000191891">
        <property type="gene designation" value="orf19.11926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07210C_A"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="Q59WC3"/>
    <dbReference type="OMA" id="GCDFKFS"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072488">
        <property type="term" value="P:ammonium transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
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    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="327"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="580" mass="65256" checksum="22F294F98E7BF56C" modified="2005-04-26" version="1">MSTDVEPMTSLDVTTGLNSLYMLYCTAPLPLVVIGIAFFYSGLTQRRSALTMFAVPFLLAPMIIIDWFIWGYSLCYSASSNHFIGNLNYVVLRQFRNALTAEFTNTRGHVLAGAHVLFNMFFKLICVSLTFPGCIAERGRVLPMILFAFIWSVIIYNPVTYWFWNSNGWLSVDLGRLPVLDFAGGNCVHIVSGFTCLAYSYILGPRNPKLLYNYRNSNTGHIIFGTFLVFMGWIGYIAGCDFKFSFNSIYIILNTLIAACASGIVWTAIDFFFSSVPLEGESVGLKHGDSKLSNSSGDNHSPMLQAIVSRTGVSINQRLHESKSNFVEKRKFSMISFSSGIMTGLVVFTPGGGYVSSNAEFWKGIIFGVVGAISGNLATRLKYFFNIDDALDLFAVHGIPGIVGSMLTGIFANDLYDSKGGWVKGHWKQFGYQLLGLVVTSAYVFIMSMVFLYLIDLIPGFHLRIDKDFNRREREKTLKAKQLDQELESQTSPQQVVPHMSNSTEQMSFWEQVELQGTDGYEFNGEFMLDFMEFIRAIRPQDYEDDDLKDIIQAPNQYEGYIGQDFELHQEGVHNLTKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WC4</accession>
    <name>Q59WC4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ordered locus">CAALFM_C107220WA</name>
        <name evidence="1" type="ordered locus">orf19.11925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW26374.1"/>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="63635" checksum="0B95F6097DB3AC85" modified="2005-04-26" version="1">MNSLTDLPIDLLQRIIEETNRLDNHKNPSYSSLFSLSQTCRFFNRLINQVLYQHITIYDNDNKSIIQTTNQTYIHIDHLSKFIEGLSMSNFQYIKSIHIHCKSNFSSFNYDSLYTKLNQYWSYLNHPIEFINFDVENIRQKQSLDQFLSNNNCTNIMEENDEVGGVCDIHSSVSKLCNLSNLSILKVQELNQIPCHNPNLKNLNLFIEGNFMDEYIKDRVLNLEQLEILQLNTTLSTKVFVNSNINCPNLEKLSICYCHSLRESPLTFSQFAAIDFGKLIELELKLNCFHRDCDCINQFYNDLTKAQHANEFNNLQKLSIINYKSKNSSNNLCQYNYVINCQLESIFRKFPKLDYLYFNLNEFTKNDQFKINWAKFAESLQILKNLKTLIIYDFFNYWLPSMKSNQATSEILLNNCKCVECNQRRSAFNSMAEYDAANNYVHNFKNYTEPELSAESGNEYQPILLNKKCNAKLLWFIFSQLQSQQFKQSPIYSMNLSYFREDKELFSQFQELFKHNCLNNLCNDIKIGNNNTKTINLGGIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WG4</accession>
    <name>Q59WG4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alp1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">ALP1</name>
        <name evidence="11" type="ordered locus">CAALFM_C110800CA</name>
        <name evidence="10" type="ordered locus">orf19.9873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713942.1">
        <property type="nucleotide sequence ID" value="XM_708849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WG4"/>
    <dbReference type="SMR" id="Q59WG4"/>
    <dbReference type="STRING" id="237561.Q59WG4"/>
    <dbReference type="GeneID" id="3644437"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110800CA"/>
    <dbReference type="CGD" id="CAL0000201651">
        <property type="gene designation" value="ALP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10800C_A"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_2_1"/>
    <dbReference type="InParanoid" id="Q59WG4"/>
    <dbReference type="OMA" id="AMFSTAN"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000129">
        <property type="entry name" value="Lysine/arginine permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="52"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000201651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="543" mass="61357" checksum="4E361BD587834E45" modified="2005-04-26" version="1">MSVEYPNSVTSLDKKPQVDLENVIEDASTSSEHRVAQTENLNRSLGARTINLICLGGVIGTGIFLGMGKMLSNAGPLGLLLNYLIMGSMIYFMMLSLGEMSVQYPISGSFAVYTKRFGSDSLAFATLFNYWLNDCVSVAADLVALQLVMQYWTNFHWYVISIIFWVFLLLLNVLHVRLYAEAEYSLALLKVVTIIIFFIVSIICNAGKNPQHEYIGFKYWSYGDAPFVDGIRGFSKVFASAAYSFGGLESVSLTAGETKNPTRVIPKTVQMTFFRVLIFYILTAFFIGMNIPYDYPNLLTKKVATSPFTIVFQMVGAKGAGSFMNAVIMTSIVSAGNHALYAGSRLAYNLSLHGYIPKIFLPMNRFRVPYVAVIITWLIGGLCFASAFVGSGELWSWLQAIVGLSNLISWWVIGVVSIRFRRGLEKQGRTHELLFKNWSYPYGPLYVVILGGFIILVQGWTTFSPFSVNDFFQSYLELGVFPLCFVFWWLVVRKGKDKFVKFEDMDFDTDRYYETPEEIEKNRYANSLKGWAKFKYNFADNFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XX2</accession>
    <accession>A0A1D8PIN3</accession>
    <accession>Q59XS9</accession>
    <name>MP65_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cell surface mannoprotein MP65</fullName>
            <ecNumber>3.2.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Mannoprotein of 65 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Soluble cell wall protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MP65</name>
        <name type="synonym">CMP65</name>
        <name type="synonym">SCW1</name>
        <name type="synonym">SCW10</name>
        <name type="ordered locus">CAALFM_C210030CA</name>
        <name type="ORF">CaO19.1779</name>
        <name type="ORF">CaO19.9345</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
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                <person name="Magee B.B."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
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                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1996" name="Infect. Immun." volume="64" first="2577" last="2584">
            <title>Purification and biochemical characterization of a 65-kilodalton mannoprotein (MP65), a main target of anti-Candida cell-mediated immune responses in humans.</title>
            <authorList>
                <person name="Gomez M.J."/>
                <person name="Torosantucci A."/>
                <person name="Arancia S."/>
                <person name="Maras B."/>
                <person name="Parisi L."/>
                <person name="Cassone A."/>
            </authorList>
            <dbReference type="PubMed" id="8698482"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 33-45</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>GLYCOSYLATION</scope>
        <scope>IMMUNOLOGICAL ACTIVITY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1993" name="J. Infect. Dis." volume="168" first="427" last="435">
            <title>Identification of a 65-kDa mannoprotein as a main target of human cell-mediated immune response to Candida albicans.</title>
            <authorList>
                <person name="Torosantucci A."/>
                <person name="Bromuro C."/>
                <person name="Gomez M.J."/>
                <person name="Ausiello C.M."/>
                <person name="Urbani F."/>
                <person name="Cassone A."/>
            </authorList>
            <dbReference type="PubMed" id="8335981"/>
        </citation>
        <scope>IDENTIFICATION AS A DOMINANT ANTIGEN</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1994" name="J. Med. Vet. Mycol." volume="32" first="447" last="459">
            <title>Differential release of an immunodominant 65 kDa mannoprotein antigen from yeast and mycelial forms of Candida albicans.</title>
            <authorList>
                <person name="Bromuro C."/>
                <person name="Torosantucci A."/>
                <person name="Gomez M.J."/>
                <person name="Urbani F."/>
                <person name="Cassone A."/>
            </authorList>
            <dbReference type="PubMed" id="7738727"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2000" name="Infect. Immun." volume="68" first="6777" last="6784">
            <title>Generation of a recombinant 65-kilodalton mannoprotein, a major antigen target of cell-mediated immune response to Candida albicans.</title>
            <authorList>
                <person name="La Valle R."/>
                <person name="Sandini S."/>
                <person name="Gomez M.J."/>
                <person name="Mondello F."/>
                <person name="Romagnoli G."/>
                <person name="Nisini R."/>
                <person name="Cassone A."/>
            </authorList>
            <dbReference type="PubMed" id="11083795"/>
            <dbReference type="DOI" id="10.1128/IAI.68.12.6777-6784.2000"/>
        </citation>
        <scope>IDENTIFICATION AS A DOMINANT ANTIGEN</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="Infect. Immun." volume="69" first="3728" last="3736">
            <title>Antigenic properties and processing requirements of 65-kilodalton mannoprotein, a major antigen target of anti-Candida human T-cell response, as disclosed by specific human T-cell clones.</title>
            <authorList>
                <person name="Nisini R."/>
                <person name="Romagnoli G."/>
                <person name="Gomez M.J."/>
                <person name="La Valle R."/>
                <person name="Torosantucci A."/>
                <person name="Mariotti S."/>
                <person name="Teloni R."/>
                <person name="Cassone A."/>
            </authorList>
            <dbReference type="PubMed" id="11349037"/>
            <dbReference type="DOI" id="10.1128/IAI.69.6.3728-3736.2001"/>
        </citation>
        <scope>IDENTIFICATION AS AN ANTIGEN</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="955" last="965">
            <title>Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins.</title>
            <authorList>
                <person name="de Groot P.W."/>
                <person name="de Boer A.D."/>
                <person name="Cunningham J."/>
                <person name="Dekker H.L."/>
                <person name="de Jong L."/>
                <person name="Hellingwerf K.J."/>
                <person name="de Koster C."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="15302828"/>
            <dbReference type="DOI" id="10.1128/EC.3.4.955-965.2004"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2006" name="Mol. Cell. Probes" volume="20" first="263" last="268">
            <title>Use of 65 kDa mannoprotein gene primers in Real Time PCR identification of Candida albicans in biological samples.</title>
            <authorList>
                <person name="Arancia S."/>
                <person name="Carattoli A."/>
                <person name="La Valle R."/>
                <person name="Cassone A."/>
                <person name="De Bernardis F."/>
            </authorList>
            <dbReference type="PubMed" id="16616453"/>
            <dbReference type="DOI" id="10.1016/j.mcp.2006.01.006"/>
        </citation>
        <scope>DIAGNOSTIC TOOL</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2006" name="Fungal Genet. Biol." volume="43" first="124" last="134">
            <title>Genomic response programs of Candida albicans following protoplasting and regeneration.</title>
            <authorList>
                <person name="Castillo L."/>
                <person name="Martinez A.I."/>
                <person name="Garcera A."/>
                <person name="Garcia-Martinez J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Valentin E."/>
                <person name="Sentandreu R."/>
            </authorList>
            <dbReference type="PubMed" id="16455273"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2005.12.002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2007" name="Eukaryot. Cell" volume="6" first="2056" last="2065">
            <title>Candida albicans Sun41p, a putative glycosidase, is involved in morphogenesis, cell wall biogenesis, and biofilm formation.</title>
            <authorList>
                <person name="Hiller E."/>
                <person name="Heine S."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="17905924"/>
            <dbReference type="DOI" id="10.1128/EC.00285-07"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2007" name="Cell. Microbiol." volume="9" first="1223" last="1238">
            <title>The 65 kDa mannoprotein gene of Candida albicans encodes a putative beta-glucanase adhesin required for hyphal morphogenesis and experimental pathogenicity.</title>
            <authorList>
                <person name="Sandini S."/>
                <person name="La Valle R."/>
                <person name="De Bernardis F."/>
                <person name="Macri C."/>
                <person name="Cassone A."/>
            </authorList>
            <dbReference type="PubMed" id="17217426"/>
            <dbReference type="DOI" id="10.1111/j.1462-5822.2006.00862.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2007" name="J. Immunol." volume="178" first="2038" last="2046">
            <title>Identification of pH-regulated antigen 1 released from Candida albicans as the major ligand for leukocyte integrin alphaMbeta2.</title>
            <authorList>
                <person name="Soloviev D.A."/>
                <person name="Fonzi W.A."/>
                <person name="Sentandreu R."/>
                <person name="Pluskota E."/>
                <person name="Forsyth C.B."/>
                <person name="Yadav S."/>
                <person name="Plow E.F."/>
            </authorList>
            <dbReference type="PubMed" id="17277107"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH PRA1 AND HYR1</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2008" name="Infect. Immun." volume="76" first="4359" last="4367">
            <title>A Candida albicans mannoprotein deprived of its mannan moiety is efficiently taken up and processed by human dendritic cells and induces T-cell activation without stimulating proinflammatory cytokine production.</title>
            <authorList>
                <person name="Pietrella D."/>
                <person name="Lupo P."/>
                <person name="Rachini A."/>
                <person name="Sandini S."/>
                <person name="Ciervo A."/>
                <person name="Perito S."/>
                <person name="Bistoni F."/>
                <person name="Vecchiarelli A."/>
            </authorList>
            <dbReference type="PubMed" id="18591233"/>
            <dbReference type="DOI" id="10.1128/IAI.00669-08"/>
        </citation>
        <scope>IDENTIFICATION AS AN ANTIGEN</scope>
    </reference>
    <reference key="16">
        <citation type="journal article" date="2009" name="J. Antimicrob. Chemother." volume="63" first="473" last="479">
            <title>Effect of tunicamycin on Candida albicans biofilm formation and maintenance.</title>
            <authorList>
                <person name="Pierce C.G."/>
                <person name="Thomas D.P."/>
                <person name="Lopez-Ribot J.L."/>
            </authorList>
            <dbReference type="PubMed" id="19098294"/>
            <dbReference type="DOI" id="10.1093/jac/dkn515"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>GLYCOSYLATION</scope>
    </reference>
    <reference key="17">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1071" last="1081">
            <title>Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.</title>
            <authorList>
                <person name="Sorgo A.G."/>
                <person name="Heilmann C.J."/>
                <person name="Dekker H.L."/>
                <person name="Bekker M."/>
                <person name="Brul S."/>
                <person name="de Koster C.G."/>
                <person name="de Koning L.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="21622905"/>
            <dbReference type="DOI" id="10.1128/EC.05011-11"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Surface mannoprotein required for hyphal morphogenesis, surface adherence, and pathogenicity. Contributes in a high proportion to the carbohydrate component of the matrix due to high levels of glycosylation and may play important roles during biofilm development and maintenance. Acts as a major antigen target of host cell-mediated immune response. Induces extensive T-cell proliferation of human peripheral blood mononuclear cells. Facilitates host dendritic cells maturation and promotes cytokine production through its glycosylated portion while its protein core is essentially involved in induction of T-cell response.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of a multiprotein complex of 250 kDa composed of at least HYR1, MP65, and PRA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 6 7 8 9 11">Secreted</location>
            <location evidence="3 6 7 8 9 11">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 9 10">Expressed predominantly by the mycelial cells. Also induced during cell wall regeneration and biofilm formation. Repressed by fluconazole.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Glycosylated protein with a polysaccharide moiety composed exclusively of mannose and glucose at a ratio of 12.7 to 1. Contributes highly to the carbohydrate component of the matrix. Treatment with tunicamycin impairs glycosylation.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Impairs germ tube formation and suppresses hyphal formation. Also decreases pathogenicity and adherence to polystyrene plates.</text>
    </comment>
    <comment type="miscellaneous">
        <text>The presence of the MP65 gene can be used as a diagnostic marker to distinguish C.albicans from other yeast or Candida species by PCR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714424.2">
        <property type="nucleotide sequence ID" value="XM_709331.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XX2"/>
    <dbReference type="SMR" id="Q59XX2"/>
    <dbReference type="BioGRID" id="1227045">
        <property type="interactions" value="2"/>
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    <dbReference type="FunCoup" id="Q59XX2">
        <property type="interactions" value="130"/>
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    <dbReference type="STRING" id="237561.Q59XX2"/>
    <dbReference type="EnsemblFungi" id="C2_10030C_A-T">
        <property type="protein sequence ID" value="C2_10030C_A-T-p1"/>
        <property type="gene ID" value="C2_10030C_A"/>
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    <dbReference type="GeneID" id="3643951"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210030CA"/>
    <dbReference type="CGD" id="CAL0000177294">
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    <dbReference type="VEuPathDB" id="FungiDB:C2_10030C_A"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_2236255_0_0_1"/>
    <dbReference type="InParanoid" id="Q59XX2"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005576">
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        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0042149">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000111">
        <property type="entry name" value="Soluble cell wall protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000426722" description="Cell surface mannoprotein MP65">
        <location>
            <begin position="33"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O22317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15302828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16455273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17217426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17277107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="17905924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="19098294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="21622905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="7738727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="8698482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <sequence length="378" mass="39264" checksum="95D903DFA54C63A5" modified="2017-03-15" version="3" precursor="true">MLFKSFVTFTVLANALAAPLAHQHHQHKEEKRAVHVVTTTNVVVVTIGNGDQTTTFAAPSVAAESSVSVSVNTEPPQNHPTTTQDVASASTYPSSTDGSAASSSAAASSSSQAGSEPSGGVGSGGAKGITYSPYSDNGGCKSESQIASEIAQLSGFDVIRLYGVDCSQVEAVLKAKTSSQKIFAGIFDVSSITSGIESLAEAVKSCGSWDDIYTVSIGNELVNAGSATPSQIKAYVEEGRKALKAAGYTGPVVSVDTFIAVINNPDLCDYSDYMAVNAHAFFDGHVVAENSGAWVLQQIQRVWTACGGKKNVLITETGWPSRGDSNGVAVPSKSNQQAAISSIKSSCGASAILFTAFNDLWKADGPYNAEKYWGIYSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YD9</accession>
    <accession>A0A1D8PIG4</accession>
    <name>CFD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytosolic Fe-S cluster assembly factor CFD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytosolic Fe-S cluster-deficient protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CFD1</name>
        <name type="ordered locus">CAALFM_C209670CA</name>
        <name type="ORF">CaO19.1387</name>
        <name type="ORF">CaO19.8965</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of 2 NBP35 and 2 CFD1 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714559.1">
        <property type="nucleotide sequence ID" value="XM_709466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YD9"/>
    <dbReference type="SMR" id="Q59YD9"/>
    <dbReference type="FunCoup" id="Q59YD9">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YD9"/>
    <dbReference type="EnsemblFungi" id="C2_09670C_A-T">
        <property type="protein sequence ID" value="C2_09670C_A-T-p1"/>
        <property type="gene ID" value="C2_09670C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643792"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209670CA"/>
    <dbReference type="CGD" id="CAL0000176016">
        <property type="gene designation" value="orf19.8965"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09670C_A"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="InParanoid" id="Q59YD9"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PRO" id="PR:Q59YD9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000278873" description="Cytosolic Fe-S cluster assembly factor CFD1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <sequence length="294" mass="32265" checksum="658916E83F87D201" modified="2005-04-26" version="1">MSSELLQEVPKSIEHVKHIILILSGKGGVGKSSVTTQVALTLVNKGFNVGVLDIDLTGPSLPRMFGVENKQVHQSTQGWVPVSVYNNNNNQGTDSKRGNLSLMSLGFLLGDRGNSVVWRGPKKTAMIKQFLKDVVWGSTETPLDYLLIDTPPGTSDEHIAIAEELRWANPIDGAIIVTTPQQVATADVRKEINFCKKVNFQILGIVENMSGFICPHCSECTNIFSSGGGKALSEQLNLTYLGNVPIDPQFVELVELQNEQENKKLIELYDDCELKPILNGIVDKILDKNLPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YJ9</accession>
    <name>Q59YJ9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA-binding translational activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">GIS2</name>
        <name evidence="4" type="ordered locus">CAALFM_C501910WA</name>
        <name evidence="3" type="ordered locus">orf19.10692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <sequence length="175" mass="18668" checksum="9BD61CA4EA6C4B63" modified="2005-04-26" version="1">MAAVYPRTCYKCGEVGHVADDCQQEERLCYNCHKPGHESNDCPDPKQNTAKQCYSCGDVGHIQTECPNQAQGAKCYNCGQFGHISKNCDSAPSSTNNAPSFKRPSGRASGTTCYKCGGPNHFARDCQANTVKCYACGKVGHISKDCHSSAGGSNFSAKTCYNCGKSGHISKECTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZH8</accession>
    <name>Q59ZH8_CANAL</name>
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        <submittedName>
            <fullName evidence="7">Translation termination factor eRF1</fullName>
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        <name evidence="6 7" type="primary">ERF1</name>
        <name evidence="7" type="ordered locus">CAALFM_C205100CA</name>
        <name evidence="6" type="ordered locus">orf19.11025</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_709807.1"/>
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        <property type="gene designation" value="ERF1"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
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        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
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        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
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        <property type="entry name" value="Peptide chain release factor subunit 1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eRF1 domain 1"/>
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    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
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        <property type="entry name" value="eRF1_Pelota-like_N"/>
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        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
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        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
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        <property type="entry name" value="aRF1_eRF1"/>
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        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eRF1_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eRF1_1"/>
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        <property type="entry name" value="L30e-like"/>
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        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000184893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="436" mass="49139" checksum="B6FE797351F87D81" modified="2005-04-26" version="1">MSETEAEKNIEIWKVKKLIKSLEMARGNGTSMISLVIPPKGQISLIQKMLTEEYGTASNIKSRVNRLSVLSAITSTQQKLKLYNSVPRNGLVVYCGDVITDEGKEKKLNIDFEPFKPINTSLYLCDNKFHVEALNELLENDDRFGFIIMDGNGALFGAVSGNTREVLHKFTVDLPKKHGRGGQSAVRFSRLREEKRHNYVRKVAEVAVQNFITADKVNVKGLILAGSADFKNELSKSDLFDNRLQAKVIKIVDISYGGENGFNQAIELSAETLANVKFVQEKKLLEAYFEEISQDTGKFCYGIEDTLKALDLGSCEKIIVYENLNTIRYTLKDIEGEEVVAHVNPELPDKSWQLDKKTGTEMEIVKEESFLEWLAENYKNYGAELEFVTDKSSEGAQFVQGFGGIGAILRYKVNFEQLADESSEDEYYDDDDDSFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-08" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZI3</accession>
    <accession>A0A1D8PHA6</accession>
    <name>GNT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Glucose N-acetyltransferase 1</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GNT1</name>
        <name type="ordered locus">CAALFM_C205050CA</name>
        <name type="ORF">CaO19.11020</name>
        <name type="ORF">CaO19.3536</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GNT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714895.1">
        <property type="nucleotide sequence ID" value="XM_709802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZI3"/>
    <dbReference type="FunCoup" id="Q59ZI3">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZI3"/>
    <dbReference type="EnsemblFungi" id="C2_05050C_A-T">
        <property type="protein sequence ID" value="C2_05050C_A-T-p1"/>
        <property type="gene ID" value="C2_05050C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643450"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205050CA"/>
    <dbReference type="CGD" id="CAL0000177663">
        <property type="gene designation" value="orf19.11020"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05050C_A"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034860_1_2_1"/>
    <dbReference type="InParanoid" id="Q59ZI3"/>
    <dbReference type="OMA" id="ILPHRVY"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="PRO" id="PR:Q59ZI3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06914">
        <property type="entry name" value="GT8_GNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000087532" description="Glucose N-acetyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DXD">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="462" mass="55312" checksum="4EB71727636B916C" modified="2005-04-26" version="1">MTSKSSSWKALLKNWEFKVAAFIGIYFLISHVVLETTDVVNEKGLKSHLKVLPEEVIDYYGKQPFSNVDKYAYMQYATNYDYLNLAIINFIHLRKANTKIPNLVIIYDEVLHYYASDKWSELYQVANQYKITLKAAPLIKASYQDDSNWAASFTKFHIFNQVEYDRIVFFDSDSMLVDIPNEIDFDNMESRFNHIDELFKIPQELSFASPQAYWLNNVVEGKSPRPRKNVEIPNKKRYSLRMKKLVNDLSIYQDFNLLPSLIYENHYFDNANHFFANHIMVITPSKNTFQELMRYIHNPWWWSITNRGSLRKPNDYDMEILNKYLNNELQRKRINVGILPHRVYGVLTGEFGEEWHERFVVEPQYLPFINKKSNKGWSPLEFFKKIKVVHFSDSPIPKPWEEENNEEHYNIKKIYCDKGDMEKFHKDYPVYKPRLTDDCDSVSIWNWFREQFYKERSGYWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A345</accession>
    <name>Q5A345_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_CR08500WA</name>
        <name evidence="3" type="ordered locus">orf19.13776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716256.1">
        <property type="nucleotide sequence ID" value="XM_711163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A345"/>
    <dbReference type="SMR" id="Q5A345"/>
    <dbReference type="FunCoup" id="Q5A345">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A345"/>
    <dbReference type="GeneID" id="3642136"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08500WA"/>
    <dbReference type="CGD" id="CAL0000176600">
        <property type="gene designation" value="orf19.13776"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08500W_A"/>
    <dbReference type="eggNOG" id="ENOG502QWR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764082_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A345"/>
    <dbReference type="OMA" id="LWENNIW"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001340">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000176600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW31530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47133" checksum="C8E4A91CE33F2056" modified="2005-04-26" version="1">MGKHRRNKKTQKSRHDPLSNPNLTTSAAINAVRGSGKQSKIGPLIDKLKSSVLNDKSMAIGVINVLAEDEQMRQELINNDIVLVLMQYCLNDANASEDILIESFGLLRNLIIEEGYDIIQFIWDNDIWTIVENNLNKINISFNYLMNHNNNDDGTSDGKPKKNLSKAKIQSLYEFSENLFTLIIMLITSDERIFDFVFNINSNGENNTGGNKIDPIVQFVLSLIDSHINNKLRLSKKLFNTLLELLFQLSTESISFVQKLSTSFDWDKLGQFLQSDANYDSTSKIYYNGIFFSLVEIVLQPSPQEKKEELMRQVLSDIIKAITVKEGSESKPKEGEEQETQDLAAFEAGCDIIATICEYLATDETNPETPARLSPETLQLLEMVGNQLVGKIEAMGVSESESSSAEAAINNLQLVISFNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A389</accession>
    <name>RS20_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS20</name>
        <name type="ordered locus">CAALFM_CR08150WA</name>
        <name type="ordered locus">orf19.6375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_711122.1"/>
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        <property type="gene ID" value="CR_08150W_A"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR08150WA"/>
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        <property type="gene designation" value="RPS20"/>
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    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
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    <dbReference type="OMA" id="IHKRVIH"/>
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        <property type="component" value="Chromosome R"/>
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        <property type="entry name" value="uS10_euk_arch"/>
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        <property type="entry name" value="RIBOSOMAL_S10"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456558" description="Small ribosomal subunit protein uS10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
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    </evidence>
    <evidence type="ECO:0000303" key="2">
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="119" mass="13345" checksum="6DE54D3EE2AD43B2" modified="2005-04-26" version="1">MSAPINKEKVEQEAEQQIHKIRITLTSTKVKQLENVSANIIRNAAQYNIVKKGPVRMPTKVLKITTRKTPNGEGSKTWDAYEMRIHKRVIDLQAPASTVKRITQITIEPGVDVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3M5</accession>
    <name>Q5A3M5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bul4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">BUL4</name>
        <name evidence="4" type="ordered locus">CAALFM_C112190WA</name>
        <name evidence="3" type="ordered locus">orf19.12710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716314.1">
        <property type="nucleotide sequence ID" value="XM_711221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3M5"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C112190WA"/>
    <dbReference type="CGD" id="CAL0000182032">
        <property type="gene designation" value="BUL4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12190W_A"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022027_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A3M5"/>
    <dbReference type="OMA" id="HINLNIV"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04425">
        <property type="entry name" value="Bul1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="2">
        <location>
            <begin position="527"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000182032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="722" mass="82744" checksum="F600BFF11FF22981" modified="2005-04-26" version="1">MNEFKSSVTPDEDVSAILPSYFMYKATVGVSVMTAEQMETQNIDPPTYINENNPGWSSSLISPISSENLSTSPVYAQQFVPSSESPVPITNEHQEVGSEEKILDNVYRLPNLSLYPNKVGDSIRLQIHFTKEIGELGKKPEFINPYVYEYQQGDVISGYIVIENASSKPIPFDMFVVLFEGVFMITNSDHGKSAIPVKIKKFLELFDFSASWTEATINRLRSESRNPYIWLDLVDPVDGISISLSNEKFLTPYKKYKRFFTFKIPHNLLDSECNNHNLSKHVKLPPTIGNISDNEQQIKTSTRSNYFFEDFSFSDTSISYGVTARFIGRVHPIEQEFGKIDIPYTDDRLQDSKGDPFIVLKELTSHVRVIPKTINLTNEAMSSKDLDNQILFENFIQRIEEKIKTGRELIKQVANATTLNNYHNVIPDIESDVAKRDQLYKPNRRRDIKQVSSSIKQYESFTLINKRSFTGTNTISGALYLSTPKVNYIIDYIPPKKYRTQSDVNSSWKLVIPLKISIKPFETPMKSQNLPTIKSISADMVVVTIKSPKYPIPIEFDHGMLYNNDTGQPFDETSFKNNIVEPFKEYALELYQLSQELGENNFNIERQLSEDIKSMCQLQCKISELHVANLKINGHSWNKKTTNWSISSKEANASVDVTIKLEYLSHQLLKSLPESLKSYNRFNFIPDFQSCYMSRLYHINLNIVLSCGTKCQLRIPLRVQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4J9</accession>
    <name>Q5A4J9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable NADPH dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Estrogen-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C601420CA</name>
        <name evidence="8" type="ordered locus">orf19.10946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Oxidoreductase that binds mammalian estrogens with high affinity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716749.1">
        <property type="nucleotide sequence ID" value="XM_711656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4J9"/>
    <dbReference type="SMR" id="Q5A4J9"/>
    <dbReference type="FunCoup" id="Q5A4J9">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="GeneID" id="3641602"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601420CA"/>
    <dbReference type="CGD" id="CAL0000196564">
        <property type="gene designation" value="orf19.10946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01420C_A"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A4J9"/>
    <dbReference type="OMA" id="YMANAVN"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000196564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="413" mass="47009" checksum="3074D0F3420ADF9C" modified="2005-04-26" version="1">MSNSNPLKDSLVFQPIKVGDNTLSNRIVYCPTTRFRAAKGNEEPTYRHVPSDLMLKYYSDRAQYPGTLLVTEATLISNRAGGYDGCPKISTQEETKAWKKIVDAVHSKGSFLSCQFWFLGRVGYPSLLKHRKLDYLAPSPIYENEKHQKQAEKAGLPLREVTEQEIHDIIYNDYTIAAKNAIAAGFDFIELHGAHGYFIDQFLHECSNQRTDKYGGSIENRCRFVLELIDHLITIVGAHRLAIRLSPWAEVQGIVEKESPIPTFSYLINELQKRADQGNQLAYLSVVEPRVQGTITADIKTMKGDNEFVAEIWKGVLLRAGNYTYDAPEFKGIVADTSNNRTLVGFSRFFISNPDLVSKLKNNPSSLVKYDRKLFYEQFNWGYNTYGQDQPVDEEKERKKFPKVIGNIDEARL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4W8</accession>
    <accession>A0A1D8PMV0</accession>
    <name>BDF1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Bromodomain-containing factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BDF1</name>
        <name type="ordered locus">CAALFM_C500200CA</name>
        <name type="ORF">CaO19.8593</name>
        <name type="ORF">CaO19.978</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="FEMS Microbiol. Lett." volume="245" first="25" last="32">
            <title>DNA array analysis of Candida albicans gene expression in response to adherence to polystyrene.</title>
            <authorList>
                <person name="Marchais V."/>
                <person name="Kempf M."/>
                <person name="Licznar P."/>
                <person name="Lefrancois C."/>
                <person name="Bouchara J.P."/>
                <person name="Robert R."/>
                <person name="Cottin J."/>
            </authorList>
            <dbReference type="PubMed" id="15796975"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2005.02.014"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="Eukaryot. Cell" volume="1" first="787" last="798">
            <title>A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans.</title>
            <authorList>
                <person name="Bensen E.S."/>
                <person name="Filler S.G."/>
                <person name="Berman J."/>
            </authorList>
            <dbReference type="PubMed" id="12455696"/>
            <dbReference type="DOI" id="10.1128/EC.1.5.787-798.2002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="334" first="1149" last="1158">
            <title>Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro.</title>
            <authorList>
                <person name="Singh V."/>
                <person name="Sinha I."/>
                <person name="Sadhale P.P."/>
            </authorList>
            <dbReference type="PubMed" id="16039996"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.07.018"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="460" last="478">
            <title>Integrated proteomics and genomics strategies bring new insight into Candida albicans response upon macrophage interaction.</title>
            <authorList>
                <person name="Fernandez-Arenas E."/>
                <person name="Cabezon V."/>
                <person name="Bermejo C."/>
                <person name="Arroyo J."/>
                <person name="Nombela C."/>
                <person name="Diez-Orejas R."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="17164403"/>
            <dbReference type="DOI" id="10.1074/mcp.M600210-MCP200"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6 7 8 9">Expression is regulated by FKH2 and repressed upon adherence to polystyrene and interaction with macrophages.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BET family.</text>
    </comment>
    <comment type="sequence caution" evidence="10">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW29466" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29466.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716816.2">
        <property type="nucleotide sequence ID" value="XM_711723.2"/>
    </dbReference>
    <dbReference type="PDB" id="5N13">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.20 A"/>
        <property type="chains" value="A=386-491"/>
    </dbReference>
    <dbReference type="PDB" id="5N15">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.37 A"/>
        <property type="chains" value="A/B/C/D=193-327"/>
    </dbReference>
    <dbReference type="PDB" id="5N16">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.76 A"/>
        <property type="chains" value="A/B/C/D=193-327"/>
    </dbReference>
    <dbReference type="PDB" id="5N17">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A/B=193-327"/>
    </dbReference>
    <dbReference type="PDB" id="5N18">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.45 A"/>
        <property type="chains" value="A/B=386-491"/>
    </dbReference>
    <dbReference type="PDBsum" id="5N13"/>
    <dbReference type="PDBsum" id="5N15"/>
    <dbReference type="PDBsum" id="5N16"/>
    <dbReference type="PDBsum" id="5N17"/>
    <dbReference type="PDBsum" id="5N18"/>
    <dbReference type="AlphaFoldDB" id="Q5A4W8"/>
    <dbReference type="SMR" id="Q5A4W8"/>
    <dbReference type="FunCoup" id="Q5A4W8">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4W8"/>
    <dbReference type="PeptideAtlas" id="Q5A4W8"/>
    <dbReference type="GeneID" id="3641592"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500200CA"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001499_4_0_1"/>
    <dbReference type="InParanoid" id="Q5A4W8"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="PHI-base" id="PHI:7195"/>
    <dbReference type="PRO" id="PR:Q5A4W8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4Y2</accession>
    <name>Q5A4Y2_CANAL</name>
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        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
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        <name evidence="15 16" type="primary">SMC4</name>
        <name evidence="16" type="ordered locus">CAALFM_C500300CA</name>
        <name evidence="15" type="ordered locus">orf19.8579</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
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        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="679"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="393"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="505"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="903"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000183293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW29476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1368" mass="155217" checksum="73994B3DC5AEF72A" modified="2005-04-26" version="1">MKRKRNTIPESDDDASFVNNSDYSVLDKSHTQQTLDGPFDVHKSESEHSIGETNESKMISHNTLETSTNTQLVSPKDTNDLKSQTDLNIENETDRPVVDGSDPVPSKKLDAPTSEAKMYSSPLSLNTHDSIAQDTKITQEKRNEPRLVIDRLVLTDFKSYAGKKVIGPFHSSFSAVVGPNGSGKSNVIDSMLFVFGFRASKMRQGKLSELIHNSGDQRPDYCQVDIHFQMVVDDLVVPQKADVVPDSELIISRKAFRNNQSSYYINGKTSSYSEVTTLLKNKGIDLDHKRFLILQGEVESIAQMKPKAEKENDDGLLEYLEDIVGTSKYKKLIEDSIVRIDELNDICLEKANRFDLVEKDKDLLEEKKVEALRFLELEKKLINCKSVQFQIEISAHQKRIAAKQAEADAIEKELEENKESNKEILEGIESELSTQKEIERDIKVLSAEIDSLGKNRKDISKKNVSLEEKSKNNANKLKKIQKSLENSKHTVSSSNQKLSNYAVTTEKFKSDIDRLNKELETEEARLNDIRSSLTEKTSEFTKEIQSLQKSLDPWDSKLKEKENEIKLAESAIEILRSQLNSTTNQLEEHKERLIQIKKLGKDKEVEYRENESKLGKIEEQIALGEEQCQTAKSALNNFKSQLMSFRQKTQDSAAIVHNTQNKNKVLTALLRLANSGRIQGFYGRLGDLGTIDQKYDVAISTAAPGLDSMVVETVETAQACIEYLRKNKLGYANFICLNKLRKFNLAPIQTPGDPSSIKRLFDLIQPSSSKFAPAFYSKVFNTLVAPNLNEAKKVAYGAKRWKVVTLDGKVVDTSGTMSGGGNYVSRGAMRLSDSSNSNDQAITADELEKMNTKLQEMENEFEQMNSDYNEKIAMLNKLQVLKPETEFAISRLKLDIQSLVSEKKEVTQICKNLIAEQQKLEENNPFEQQLLSKEKELEELVNAKTQIKEQMSGFEQKISVLEQKIMDVGGVELKVQSSKVDSIKQQISIIHEKTSGDRMTVKKLENEINRHTKLIESLTTEQEEAEAELEKINEQQRSLLSKLEEVNSKLKELEDERNDKEDNLEKMKHDLEEKQDQINKFKSVEIELLNKLEKCKGTLKGLKQAIEQNKEELDALVIRDVEPYISWLDETEQKKYNGALIDTLSEEDIADVDLEAVTSEIEELENYMANVKVDIEILKEYGAKIVEYNDKKSDLNQAVAERDSKKNYCDDLKRKRLDEFMVGFNTISMTLKDMYRMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHKYKPTPLYVMDEIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAQQLVGIYKVNNKTSSVSLANIEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5N1</accession>
    <name>Q5A5N1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C210850CA</name>
        <name evidence="13" type="ordered locus">orf19.12828</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717170.1">
        <property type="nucleotide sequence ID" value="XM_712077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5N1"/>
    <dbReference type="SMR" id="Q5A5N1"/>
    <dbReference type="FunCoup" id="Q5A5N1">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A5N1"/>
    <dbReference type="GeneID" id="3641232"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210850CA"/>
    <dbReference type="CGD" id="CAL0000178143">
        <property type="gene designation" value="orf19.12828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10850C_A"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014293_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A5N1"/>
    <dbReference type="OMA" id="AQKTIHR"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036266">
        <property type="term" value="C:Cdc48p-Npl4p-Vms1p AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="166"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000178143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="537" mass="60671" checksum="1E8CBE84AFA4D054" modified="2005-04-26" version="1">MEDFYIYNLSDKVINSLELLYFDSKTSESVKADEPPKTPQPPPNQHDTEYYKSDLYRYNLKRKLNDLPPVTEQQFDKLLEEESIESLSGSDDESDDEDKLQHLIQKLDVKDDDNDDESTVSHLNTKSPFILFGSPLVPADKAIGVYKAVFSPSQLDNPTESLHFPKTGKSALFMIGGGHFAGAIISHTRKNTRGNAPTTKESIQEQAVDIVQSKTFHRYTTRRKQGGSQSASDNARGKANSAGSSIRRYNEQALIQEVRELLHDWKNQLAECTAIYIRANGASNRKVLVGEGSPIQANDPRLRGFPFTTRRATTSELKRAWVELTHLHVVDMPKVEKKKETPKKIEKTTVSPPPPPTNTLSTDLITLLKKQKAPKLINFVKQNSIDVNEFRLDYTHTPTLLHYAAANGLGHMVQVLLVNLKANPIVYNAAGRTPAEVADTSARKVFQIVRHKLGEEYCDWNAAKVAPPKSKEEIEQEERTLHEQLELEKKQLIQQELTKPEPKKVTPSFDLTGLSDQQKMRVLREQRARAAEARMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7B0</accession>
    <name>Q5A7B0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C107810CA</name>
        <name evidence="7" type="ordered locus">orf19.12518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717589.1">
        <property type="nucleotide sequence ID" value="XM_712496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7B0"/>
    <dbReference type="STRING" id="237561.Q5A7B0"/>
    <dbReference type="GeneID" id="3640708"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107810CA"/>
    <dbReference type="CGD" id="CAL0000201274">
        <property type="gene designation" value="orf19.12518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07810C_A"/>
    <dbReference type="eggNOG" id="ENOG502RIXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392367_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A7B0"/>
    <dbReference type="OMA" id="YLKFFCK"/>
    <dbReference type="OrthoDB" id="4077024at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="653"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000201274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="756" mass="85030" checksum="FCCA63A282FD6961" modified="2005-04-26" version="1">MNGSVDLNNKSLSQPATPPRSSPNTTIDHSQSLPNSILRGSRRTSIYNIPLPPHGLSEATTFLSQQLQHQLSERGRSRSRHSTHNTTSNHGSVTPKSRRSVTPNSRMSLTPIRSRRNSRRRSSIIITKTGEKLYEPNYQGPITIDYLKFFCKTSIQNQDKINQQQQQQRQQQLGEPFVDTRDLVTSEERNDSRISETSKHVTQESTNVVSPFEKNESNSPLQIQEEFSQSLIIPSNNDNILESLDETKQDVNDVVLQEQHSHIDEMPQHDKDSPEKPKPLSYLQKILLAKSKKSSLISRKTSDETPTKEVVPKLDDLKQSEENDASTVDTGKQDSQFEQDNGEIIDKIDHFAIQDNSKISNSIFPDWRDNSESAGASAGATTISNTSSNNVNTKGPSTDILNDLESAEDNQTTVVGDSIKDFEPDKEDRVPVTTSSTESNGQQTETVELAKSQSDELNTKENENEGSNEIDWNIQEPDFALMDDEVPSQEPTPTNEIEEMNEPHESSSHEDDITPPLTNTQEGGSLSMAKDQVTPENLFISDQQLIDEEASDASENEIIQDEFFVDNDQSASIFEGIDDDIEEDESTDDNDQEFGLEPGKSNRVHLTRIIPQKRKQSPVSSTGVDVSIRDVSYIVKSIQAHKSLNTNLPSRKKFKKPKSLSREIVKSIQEKSNEFLDTLMDDLKSYAEHRQSQTVDMKDVLLYLQRINFAGKGSSTNETEIDRISELAQKFLPLENLIALDNDLYDTISPQKKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A945</accession>
    <name>Q5A945_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Origin recognition complex subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ORC6</name>
        <name evidence="9" type="ordered locus">CAALFM_C101000CA</name>
        <name evidence="8" type="ordered locus">orf19.10799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718112.1">
        <property type="nucleotide sequence ID" value="XM_713019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A945"/>
    <dbReference type="FunCoup" id="Q5A945">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A945"/>
    <dbReference type="GeneID" id="3640180"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101000CA"/>
    <dbReference type="CGD" id="CAL0000183337">
        <property type="gene designation" value="ORC6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01000C_A"/>
    <dbReference type="HOGENOM" id="CLU_060403_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A945"/>
    <dbReference type="OMA" id="ARYHICA"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016811">
        <property type="entry name" value="ORC6_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022941">
        <property type="entry name" value="ORC6_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="363" mass="41148" checksum="56161085CFE6B7CA" modified="2005-04-26" version="1">MSSSQARKALQDVIPNYLGEFTPKLLDYINSLYQLSLRKQAILPNKSEIARFHLCAVVIVEKYKQSFELPTPDVSRIPTQPKVAAKLLDTFRELIEQISAASTPVSSPKKVKPPSQSPSTPTKSRTSKENLKSGSPLKRLRAEMLQEDQVNGNSPDGQLKDVDSPFNPKKRKESKAGTPTHKVYKYDKKHVSIADFIAFCNTFLIPGDITAKMVGTFLTHQHKFLKKSDWSLACGMVYAAYIRINNRLLAQSVGTKSEFTKQLLQYQKGGLSLGAMQSWCGIIEEWIQDEPWIQEIEKTYAYGSKTAEETRNSFERKAKIGEGWDLMEQFGAMIHGETISLSSHQEEYYKNWRKEALEKCDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A9A6</accession>
    <name>Q5A9A6_CANAL</name>
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        <name evidence="6" type="ordered locus">orf19.10091</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_713133.2"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="768" mass="85842" checksum="5C23CAAA8D44E092" modified="2005-04-26" version="1">MDKKSKLFKYPLSEETAKFEYRLLNPNGKLSDIWLHEEYQKLSLSAIDKVSQQPSAVTTAPSQPHRENSRKRNAGDDDVYDQKNMPSCDDTASSDTDCQSQVSSTAHLHSYRSNGLVEPPSKRRLTTTNETSLSSAGATTFQIESPGSISAITTNNSTTSAGDSNNSNSFSDQHSRHPRTPNVMNSPTHTPISDIEEDPIQQLPLPSPSASPIQSDTENEHVTTSDSLQGKANLDSIENVMSNEPTTQSELVDLVTKLSGFLSEANQNHLVFKLLQKTTRPTLSTFNNLINNSLKRDILSNVPFEVTMKILSYLDYKTLLSVAQVCKKWFDIINNPDTWIKLLKRDKLITDDAVIKYELQYPDQLLREWSTLPEINSAQVLYKKRKIIVNRWMDPKFKPHRISVSGHGNKVVTCLQHDDEKVVTGVDDKCILIYSTQTGQLMKVLEGHEGGVWALKYTGNTLVTGSTDRTVRVWNMKTGQCTHIFRGHTSTIRCLDIIHPAVIGKNQDGEDIVFPEYPLLITGSRDHNIHVWKLPVVDDSQDYIETFEGEFDNPYLIAVLSGHTQSVRSISGYGNIIISGSYDSTVRVWDLLDDGHCTHVLQGHLDRVYSTAIDFHSKTCFSGSMDSNINVWNFETGELKKVLVGHASLVGLLDLVDDVLVSAAADATLRIWDAKTGELRSKLKGHGAAITCFEHDGLRVVSGSEKMLKLWNVEKGTFARDLLSDVTGGIWQVRFDYKRCVAAVQRIINEDEGETFIEILDFSQPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB78</accession>
    <name>Q5AB78_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps53p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">VPS53</name>
        <name evidence="10" type="ordered locus">CAALFM_C100130CA</name>
        <name evidence="9" type="ordered locus">orf19.13513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719053.1">
        <property type="nucleotide sequence ID" value="XM_713960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AB78"/>
    <dbReference type="SMR" id="Q5AB78"/>
    <dbReference type="FunCoup" id="Q5AB78">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AB78"/>
    <dbReference type="GeneID" id="3639319"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100130CA"/>
    <dbReference type="CGD" id="CAL0000194290">
        <property type="gene designation" value="VPS53"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00130C_A"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AB78"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.110:FF:000009">
        <property type="entry name" value="Vps53p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="8">
        <location>
            <begin position="541"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000194290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW25715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="699" mass="80718" checksum="1E4A759DD56A361D" modified="2005-04-26" version="1">MDSPTYDPTTHLNKIFSSPDTLNELPQLLNHVSQYKRQLTEEINKSTAKYERVDLSEDISHLATSIGEIKRDSSMTKQSISQMTGSIQRLDCTKKNLVASMTLLKRLQMLVNVNNTLSSILPSHDYKEIYQLLGVLKELLQFFQPYKSIDEINQINLMVVHTQNKLIDDIFMDFEEYKNKDEEQLLFGARILELIDVKYKDKLLAWFYNLQLQDLQEIFSGEAGSLDNLNRRFIYFKNILKQVQQYKIFPWDISNAITQEFCQITRQDISKLLYNSKIESKTLLDNLTKTLEFEKSLGLHNEISSVFEPYLSIWVHEQDKYLNSKMLEFSAVPQLPPDVPNIAVSSTELFKIFNRLLSHITKLTNGDTIVDLARVFNKYLSEYNRRILAPILSTDDFGAESLKYFTMLLNTGDYIINNIEELADKIQKTTTHTIAPFNTDAFYQLINKSISSLLLKMSIDYKPCWREFFNLDWGQLDSVNDISSYMNDLKSKTAENLRVILPLIIRDSYVRNFNDKLVEMLVTTIANNLKFVKPMTATSVEQILMDVSSLKEDALRFPLFSVKDVSKSYQKFVNHQFGDLQSLLKLLMVPSIPVENLIESYFALIGDKSVSNFVKVLKLKGVDKAQHHKYVDNFKLQLSVDDGSVTSCLLLQNLEEEEEASRAATPDVKLNEKFDVSKINENFKNFGKFFRKDIGNESS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB93</accession>
    <accession>A0A1D8PC65</accession>
    <name>PNS1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PNS1</name>
        <name type="ordered locus">CAALFM_C100310WA</name>
        <name type="ORF">CaO19.13498</name>
        <name type="ORF">CaO19.6077</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719039.1">
        <property type="nucleotide sequence ID" value="XM_713946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AB93"/>
    <dbReference type="SMR" id="Q5AB93"/>
    <dbReference type="FunCoup" id="Q5AB93">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AB93"/>
    <dbReference type="EnsemblFungi" id="C1_00310W_A-T">
        <property type="protein sequence ID" value="C1_00310W_A-T-p1"/>
        <property type="gene ID" value="C1_00310W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639298"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100310WA"/>
    <dbReference type="CGD" id="CAL0000201857">
        <property type="gene designation" value="orf19.13498"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00310W_A"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AB93"/>
    <dbReference type="OMA" id="DTIFVAM"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="PRO" id="PR:Q5AB93"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000191731" description="Protein PNS1">
        <location>
            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="133"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="373"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="439"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="518" mass="58064" checksum="CBA1BD42560BF77A" modified="2005-04-26" version="1">MSDYPPPNYPPPNHPQYQQQQDETYHVRPDMERQQDFGYYEKPTPSQNFDDSFKVEKPKFNDWPFAIFFWLVVAGFIAVAGITLNALRSTYGFQGGSIYGSGNTFTLNTNTIILFAFIIVMAFILSAAIIVFARLAPKAFIVTGVILNVVLGIGTAIFYFVEKYYSAAIVFLIFALFGAWCYWSSRHRIPLSATILTIVIDVMKMYPSTLIASFIGLIFSAAFSALFSIVIVATYVKYDPNSNNEACSVGGGSCSKGKLIGVLVFVFFAGYYISEVIRNVIHVVIAGIYGTWYYLANSDQGAPKHPALSSLKRALTYCFGSITFGSLIVSLIQLLRQFISILRSNFAADGNGWGVCGMIILDFFVGFIDWLVRYLNKYAYCYVALYGKSYIKSAKDTFDLIRFKGMDALINDMFINTALNLYSLFVAYLVALLAYLYLKFTKPEYNSGGAFYAPVIAFAFLIAGQINRISLTVIESGTATFFVALAKDPEIFQMTNRNRFDDIFRNYPQVLEKITSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADY2</accession>
    <name>Q5ADY2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C307760CA</name>
        <name evidence="4" type="ordered locus">orf19.14001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719809.1">
        <property type="nucleotide sequence ID" value="XM_714716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADY2"/>
    <dbReference type="SMR" id="Q5ADY2"/>
    <dbReference type="STRING" id="237561.Q5ADY2"/>
    <dbReference type="ESTHER" id="canal-q5ady2">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="3638450"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307760CA"/>
    <dbReference type="CGD" id="CAL0000198949">
        <property type="gene designation" value="orf19.14001"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07760C_A"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_3_1"/>
    <dbReference type="InParanoid" id="Q5ADY2"/>
    <dbReference type="OMA" id="YLEWNPQ"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000198949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="308" mass="35752" checksum="E969BBBDD2D7BF00" modified="2005-04-26" version="1">MTKFDIKLHNGRRTFSTLSNLPETEVSGLQWDRAIILIHGFPDVNTTFNKAWPYLEDSFAGEKVLLLAPKLRGYEKSSIGPESEYALPYLAEDVKAWIEEINPGNKKPVHLLGHDWGAMVSFKTANLYPHLVTSIVTLAIPYLANLHLWDLLWYAPEQFYLSSYFLTMQIASVYRPKLTESNDYLKYLWKYWSPSYNTSKEEIDEIRNAFTKDNVVDAVTSYYRHLFRPFSLVKSRWPVDFNRVPTLILVGKEDGCMSPRIAELEKEKLKDFPKAEVKILPNAGHFLQREQPEIVAKISIDFFEKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEI3</accession>
    <name>Q5AEI3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C302920WA</name>
        <name evidence="4" type="ordered locus">orf19.7917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719982.1">
        <property type="nucleotide sequence ID" value="XM_714889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEI3"/>
    <dbReference type="STRING" id="237561.Q5AEI3"/>
    <dbReference type="GeneID" id="3638379"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302920WA"/>
    <dbReference type="CGD" id="CAL0000186920">
        <property type="gene designation" value="orf19.7917"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02920W_A"/>
    <dbReference type="eggNOG" id="KOG4076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101493_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AEI3"/>
    <dbReference type="OMA" id="IYRMYGK"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000186920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="129" mass="14408" checksum="D230D111BC5A2F52" modified="2005-04-26" version="1">MSYSEEDPLSEPKNTQQLDLSKLSPQELRIYKMYGKLPTTQQILSSKFQDKKYFDSGDYAMQKQMGGGLKSGIPGGMSMKHPNAERMKEMSVRNSISATNAQVLLNGKSGLLNERTVGKDDNGEEQNKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEM5</accession>
    <accession>A0A1D8PJJ3</accession>
    <accession>Q5AF12</accession>
    <name>OXR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">OXR1</name>
        <name type="ordered locus">CAALFM_C302540CA</name>
        <name type="ORF">CaO19.243</name>
        <name type="ORF">CaO19.7873</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719942.2">
        <property type="nucleotide sequence ID" value="XM_714849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEM5"/>
    <dbReference type="SMR" id="Q5AEM5"/>
    <dbReference type="FunCoup" id="Q5AEM5">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AEM5"/>
    <dbReference type="EnsemblFungi" id="C3_02540C_A-T">
        <property type="protein sequence ID" value="C3_02540C_A-T-p1"/>
        <property type="gene ID" value="C3_02540C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638372"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302540CA"/>
    <dbReference type="CGD" id="CAL0000197295">
        <property type="gene designation" value="OXR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02540C_A"/>
    <dbReference type="eggNOG" id="KOG2372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029204_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AEM5"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="PRO" id="PR:Q5AEM5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000058111" description="Oxidation resistance protein 1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="114"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="345" mass="39398" checksum="6429DD0BE5228919" modified="2017-05-10" version="2">MSFLFRRSIEQPRVNEKETNKEVKDEPQHQQQEKEDDNSKQEELLSDSVNEKPKEQPKPVKRRGTFFGNLLGNGSKNSSSASLNSSHSSVSSSSKFPPLGPLTLTGYKESTHHRLLDSELANNIRNLIPARFQLFDNWELVYSLEQHGISLNTLYRNSNPEHQLRLLKKQKAAEKGFADSIVKNMVVGDTSRPRYSFEPKRSQSYVLVIKDNHNNKFGAYLSENLKPMEHRRYYGNGECFLWKCEKYDPSKLDHAVDKRATQEIRFKAFMYTGINDNIIYSNHDFIAIGSSNGQNGLFIDKSLLSGVSYSCDTFGNEILNSSPQNAKFGSFKIKGLEVWRIGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AF37</accession>
    <name>Q5AF37_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C402340WA</name>
        <name evidence="7" type="ordered locus">orf19.10285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the heterodimeric LMA1 complex together with the thioredoxin II/TRX2. LMA1 binds to the ATPase SEC18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720519.1">
        <property type="nucleotide sequence ID" value="XM_715426.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AF37"/>
    <dbReference type="SMR" id="Q5AF37"/>
    <dbReference type="FunCoup" id="Q5AF37">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AF37"/>
    <dbReference type="GeneID" id="3637883"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402340WA"/>
    <dbReference type="CGD" id="CAL0000188954">
        <property type="gene designation" value="orf19.10285"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02340W_A"/>
    <dbReference type="eggNOG" id="ENOG502SBW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1970218_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AF37"/>
    <dbReference type="OMA" id="FHYFHTA"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000188954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="127" mass="13629" checksum="C7607B30EA4FF71F" modified="2005-04-26" version="1">MNQNKKLTGLILLAIISIITLFNFKTISQITAIRSFVSPASSTATNTNTKSTMSDSKGYIITLKDTCADSEASSIKSKITELGGKITNEFSLIKGFSAQLPTIHAEALPKDFAGIANIEEDGEVRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALV8</accession>
    <name>Q5ALV8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">CDC55</name>
        <name evidence="7" type="ordered locus">CAALFM_C201600CA</name>
        <name evidence="6" type="ordered locus">orf19.9043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722518.1">
        <property type="nucleotide sequence ID" value="XM_717425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALV8"/>
    <dbReference type="SMR" id="Q5ALV8"/>
    <dbReference type="FunCoup" id="Q5ALV8">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALV8"/>
    <dbReference type="GeneID" id="3635785"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201600CA"/>
    <dbReference type="CGD" id="CAL0000191618">
        <property type="gene designation" value="CDC55"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01600C_A"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="InParanoid" id="Q5ALV8"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="442"/>
        </location>
    </feature>
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            <end position="420"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="CGD" id="CAL0000191618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="519" mass="59094" checksum="CFB4A033B865E8C4" modified="2005-04-26" version="1">MPSDKNWKFSQCFGDKGDIENITEADIISTVEFDHTGDFLATGDKGGRVVLFERAETKPKQGCEYKFFTEFQSHDAEFDYLKSLEIEEKINKIKWLKSGNDSLYLLSTNDKTIKLWKIQERQIKLVSENNLNGSTHLPSTDIGISSLKLPQLQLHDKLISAQPKKIYANAHAYHINSISVNSDQETYLSADDLRINLWNLGIADQSFNIVDIKPANMEELTEVITSAEFHPSQCNLFMYSSSKGTIKLSDMRSNSLCDSHAKIFEEYLDPSSHNFFTEITSSISDVKFSHDGRYIASRDYMTVKIWDLAMENKPLKTIDVHEHLRERLCDTYENDAIFDKFEVQFGGDNKSVMTGSYNNQFVIYPNAVNKGGNDKPKSVFKNNTNKRKKNGYRGRDDDDDEDNNNDDDDDDDDDDDDEDNQFDKEVPVSKNSPSSQLDYYDDDDEPEKITLQADKSAFKSKKISPHTVSGRMMSGVGGNIGRDFEDVDFKKSVLHLSWHPKENSVAIAATNNLYLFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMR3</accession>
    <name>Q5AMR3_CANAL</name>
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        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C402080WA</name>
        <name evidence="14" type="ordered locus">orf19.12052</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_717562.1"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.Q5AMR3"/>
    <dbReference type="GeneID" id="3635643"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402080WA"/>
    <dbReference type="CGD" id="CAL0000179012">
        <property type="gene designation" value="orf19.12052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02080W_A"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q5AMR3"/>
    <dbReference type="OMA" id="VYRESGW"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000179012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="309" mass="35071" checksum="D46C12BC06141F8D" modified="2005-04-26" version="1">MSIVVQDKEDQILTQLEHPQPDTKSPPKYIAYLAGVCSGINKNLVGHPFDTWKSRLQTAPKGRFKGPIDCAWQTLKYEGPFGFYKGFTPPLVGWVFMDSIMLGSLHTYRELVKDYIYPQEKKLPLVGHMIAGLGSGLTVSFVAAPIEQCKARLQVQYDKKSRTYSGPIDVAKKVYQAAGIRGIYSGLISTMIFRTNFIFWWGSYEIFTQYFEKNTKMSTPSINFWAGGLSATVFWIFAYPADVVKQNIMTDSPIQSEKKFPRWIDAVKYIYKEKGWRGFTKGFGPAILRSFPANAAALLAFEWVMRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMR6</accession>
    <name>Q5AMR6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C402110WA</name>
        <name evidence="4" type="ordered locus">orf19.12049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722652.1">
        <property type="nucleotide sequence ID" value="XM_717559.1"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW28540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718119.1"/>
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        <property type="gene designation" value="orf19.13424"/>
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        <property type="component" value="Chromosome 3"/>
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            <dbReference type="CGD" id="CAL0000186615"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="595" mass="67620" checksum="F86380DCF7D7369B" modified="2005-04-26" version="1">MAINTHQPLNHPSLDTISVSISSSHPSIDSINSSCIMQKHKHQLLLPQTEKYNNNNNNISAYQPDKQLLQQKQSKTKNSQSEYSPKRRTKMKKSFSINNIKQITSSIDNHPLNHNYNDTDTDTNPSTNSHGENNFEDYQDDSMELDDDYDSDDLSYTSCSSSQSNSNYSVVFEKDPTTMSPTSDQIPFSYHSFNNDCFLYTNTKSSLGISIPMNRSHPMSSSLQSPISSQSLLSMSPPPSVFCLPSTTTSCSPITTNSISQSLEMERSLRRSSSSDSLYMLLKNASTSSSTPFSSSSPSTQSSSPSPTSTSLSLFSKKQSIKSTSKKSIYSNLSTSLRSFRNKLSSYNKENLLKFIMDSPRLTDEKLPLQKPSCPEAKVQEEETEETEETEETEETPMEELTTFHHHQHHNHHHELGLEKSQCIKYKTRESRTNSRFLILYAFDMNARCNSMTLPNSPTQDELYKIIKRHPNIKKFHYKHNIHRISNMSREKLWNNVILPPRQDDSPELFIKSDPYIIYNDHNELDNGLDGHYSIVRKSGKYMPWALKPSIKPAGVLPNSKWVFNGQAPNSGITKTQFTVKGWCNPRWVDHTPTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2025-06-18" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APG6</accession>
    <accession>A0A1D8PEK2</accession>
    <name>CEF1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CEF1</name>
        <name type="ordered locus">CAALFM_C109370WA</name>
        <name type="ORF">CaO19.12262</name>
        <name type="ORF">CaO19.4799</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CEF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="C1_09370W_A"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_09370W_A"/>
    <dbReference type="eggNOG" id="KOG0050">
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:filamentous growth of a unicellular organism"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb_dom"/>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
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        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000197096" description="Pre-mRNA-splicing factor CEF1">
        <location>
            <begin position="1"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type 1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type 2" evidence="3">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="610" mass="70172" checksum="DBFCB6B67FB7DFA0" modified="2017-05-10" version="2">MAPPLYVKGGVWTNVEDEILKAAIQKYGIYQWERISSLLPKKSAKQVKARWVEYLSPLLNKTDWTKEEDEKLLNLHKIFPNQWRSISNILNRTAVQCVERYQKLIDEAAGIKPGDDEENLGLSGPGIETLPAVGASSGLAVGEMNLNPESKPARPDDEDLPDDEREMLAEAKARLGNIQGKKAKRKARERMLEESKRIALLQKRRELKSAGINVKLTTRNKKKRKEFDYNADIPHEIIPQAGPYDTAEELKQNDFEKQQFGQQVSTKGISMKDIDDRIAKEESRRKKEIEKKKLERKREFNAAASLISEHEDSKRRKLNLPEPGTHNFEKTKSDVLTLTNQANNKLSEKEIARNQNKKRAAVAQLIKATFERLPPPKHETGEILPFVSTNILEFRNDVNANDISDIAGAKLPDETATNVSTLISRVVQRELPIPHPNNLRDLSTVKFDTLVDKLIAEECHRLIRSDYKQYHDTTINGVSTDKYDRDLLEKINQDIDKEFAQMDVSTVHSFEDYVLPKNFKVAESIIENLHTFHNENEKLTNKILESTNYEDQRDQKLQQLTHLWRELSDVNLSYSIEKKLFELESSAIDKELLRLRSEIDKLNKKIETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APN0</accession>
    <name>Q5APN0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">CAALFM_C108780WA</name>
        <name evidence="17" type="ordered locus">orf19.12198</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723423.1">
        <property type="nucleotide sequence ID" value="XM_718330.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APN0"/>
    <dbReference type="SMR" id="Q5APN0"/>
    <dbReference type="FunCoup" id="Q5APN0">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5APN0"/>
    <dbReference type="GeneID" id="3634789"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108780WA"/>
    <dbReference type="CGD" id="CAL0000197686">
        <property type="gene designation" value="orf19.12198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08780W_A"/>
    <dbReference type="eggNOG" id="KOG4126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="InParanoid" id="Q5APN0"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047386">
        <property type="term" value="F:fructose-2,6-bisphosphate 6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.40:FF:000002">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000197686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW26515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="551" mass="60737" checksum="01AA594AD4EC2151" modified="2005-04-26" version="1">MGLSNDQSPLLGGDSLTCWNKKQSGIKRNLSYLLNIITIGIIAYLCIFAKHSDNDDNTGLSLNPQKKKNIIMMVTDGMGPASLSAARSFRQFRDKLAINDILTLDKYLIGSSRTRSSSSLVTDSAAGATAFSCALKSYNGAIGVTPDKTPCGTVLEALKLQGYYTGLVVTTRITDATPAAFSSHVDYRFQEDLIAQHQLGEYPFGRAVDLILGGGRCHFLPTSEGGCRADNRNLIKEYSDKWQYVGDRVSFDQLQGGKNVSLPLLGLLANTDIPYDIERKDSEYPSLAEQVQVALTALSEATKDSEQGFFLLIEGSRIDHASHHNDPAAHVREVLAYDRAFEEVIKFIDNSEIETVAISTSDHETGGLVVARQVSESYPDYLWYPEVLLNSTHSGDYLSHKVVHYKEKDNTKKFTNFIKHEILEKDLGISDYTAKDVDLIIEKANNAGELLYVLNNIVSIRAQIGWTTHGHSAVDVNIYAHTNSPAIKSKLLSHKAYDGLSGNHENIEIGAFIEYITGSDLNQVTQLIKKTEHSPDNNKAKVDDIFHANVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q9UW26</accession>
    <accession>A0A1D8PN98</accession>
    <accession>O93834</accession>
    <accession>Q59YI3</accession>
    <name>PAPA_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Poly(A) polymerase PAPa</fullName>
            <ecNumber>2.7.7.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Polynucleotide adenylyltransferase a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAPA</name>
        <name type="synonym">PAP99</name>
        <name type="ordered locus">CAALFM_C501780WA</name>
        <name type="ORF">CaO19.3197</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Science" volume="285" first="1271" last="1275">
            <title>Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Hull C.M."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="10455055"/>
            <dbReference type="DOI" id="10.1126/science.285.5431.1271"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1998-12" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans PAP99 gene, a putative homolog of the C.albicans PAP1 gene.</title>
            <authorList>
                <person name="Nagahashi S."/>
                <person name="Ishii N."/>
                <person name="Aoki Y."/>
                <person name="Arisawa M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19"/>
    <dbReference type="EMBL" id="AF167162">
        <property type="protein sequence ID" value="AAD51407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB021667">
        <property type="protein sequence ID" value="BAA36217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9UW26"/>
    <dbReference type="SMR" id="Q9UW26"/>
    <dbReference type="FunCoup" id="Q9UW26">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9UW26"/>
    <dbReference type="EnsemblFungi" id="C5_01780W_A-T">
        <property type="protein sequence ID" value="C5_01780W_A-T-p1"/>
        <property type="gene ID" value="C5_01780W_A"/>
    </dbReference>
    <dbReference type="KEGG" id="cal:CAALFM_C501780WA"/>
    <dbReference type="CGD" id="CAL0000194576">
        <property type="gene designation" value="PAP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01780W_A"/>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="InParanoid" id="Q9UW26"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000051619" description="Poly(A) polymerase PAPa">
        <location>
            <begin position="1"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="1">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="1">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="1">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="1">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; BAA36217." evidence="3" ref="2">
        <original>N</original>
        <variation>K</variation>
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; BAA36217." evidence="3" ref="2">
        <original>Q</original>
        <variation>R</variation>
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="555" mass="63289" checksum="5C76DA500616042A" modified="2000-05-01" version="1">MNNQAYGVTPPISVANSTPKENELNDSLIKELKSRGSFESETATKKRVEVLNILQSMTEEFVYKVSIKKNISEGMARDVGGKIFTFGSYRLGVYGPGSDIDTLVVVPKHVSRNDFFEVFYELLKGRSELEEIAPVPDAFVPIIKIEFAGISIDLIFARLDIPRVPRDLTLDDKNLLKNIDEKDLRALNGTRVTDEILQLVPKPTVFKHALRCIKMWAQQRAVYGNIFGFPGGVAWAMLVARICQLYPNAVSAVIVEKFFHIYSQWAWPQPVLLKQIEDGPLQVRVWNPRLYALDRQHRMPVITPAYPSMCATHNITSSTQKVILSEFQRGIELMNDINVGKKSWSDLLERHDFFFRYKFYLCIVAATRSTYAEHLKYSGMVESKLRLLVQKLELVEGIELAHPYVKSFENGYYCDNAEEAHEIMNLYGTSKGDDRVKGVLHAENNDNNKENVENKVELHMTKLFIGLKLDLSKEGEKKLDIQYPCAEFFNICKGWQDFDSEKHFIQIKNVKLYDLSDDVYVDGETRPIKIAKRKRAVSKNEGKKKPKSVGTVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCA6</accession>
    <name>A0A1D8PCA6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaphase promoting complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">APC1</name>
        <name evidence="9" type="ordered locus">CAALFM_C100600WA</name>
        <name evidence="8" type="ordered locus">orf19.13467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719008.2">
        <property type="nucleotide sequence ID" value="XM_713915.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCA6"/>
    <dbReference type="SMR" id="A0A1D8PCA6"/>
    <dbReference type="FunCoup" id="A0A1D8PCA6">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCA6"/>
    <dbReference type="GeneID" id="3639383"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100600WA"/>
    <dbReference type="CGD" id="CAL0000196687">
        <property type="gene designation" value="APC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00600W_A"/>
    <dbReference type="eggNOG" id="KOG1858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCA6"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000435">
        <property type="entry name" value="Ubiquitin ligase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="7">
        <location>
            <begin position="647"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000196687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1535" mass="172803" checksum="F1B706AB5EAE674E" modified="2017-01-18" version="1">MTSSQGNDILKFPILNIQEDMDYPVPFQDPYQLALFSQNKQLLIAKRKLVVIKGSIIMKVLTYEEDIVTATYTHFSNSQELEEVLVVSLKKHIHVYYPDGKSYVCSLPFALKNALPFESGLVLQRDQNESLIPHNGALYSNTSHLNSAAILTLVDPMGDFRIVATASTSVISSKEEVMTFPRKDMSKVCSLCVTFNASDGSISIYHVKAPSRTTTFGKTQSARNQKRRYGSITTPNPSRILEEENGTEPLHSISLNMEKKRTSTLLSDISSVGRVSSDCHSLSQDFSGFKKDMILSRVESFGNKLQKDQLRIFNIWFEDQEGVVIFNRIKKECAVLIYRNPSFSRHLSVFKTSCLDCIPLTSTKHEGNLIILTEHQKFSIINPFLGMKSASHTFGNKLKVRSLIDSYDSKLALKLIDGSEMIIKIVLEPSSELVKMCLMCFRYLSGSSINHIMWMLWRSAYVEIKYADEWEAFVAALLSLIFPFSEGAQCVQNEITKLLPVAKRIHETSDVNYNLHDLIPYITISLHLIREEIRLDSTKAKCLNNINLLLCQLTTWMGWPAPWIKYYSIKPENIDPNTRFLSALILEAPPNLLRSLASLFTNNIVRYLTFSQLVEETETVDLLVTPRTFYVLKLFEVLVSSQYGPSAIVSLMLEFGITKDLLETYPLGISIPLKEALSICQESPEFEWTSQTLDLVGRKDLNKLFLDADFSADINTEPHTSTKDLSSLLNEVLEDNENFSPWDGQSEAERMNITKLIFEADRRYFEITTLLHQTKTQTAYLKVDENVTEYDLVLQQRELAVIVALRTLTIPLGRAALVYASRNPLLTEKFPIPKFNLNTLISPTMTNIVYSEDRVSKSFSEWGHFHNGVSSGLSIGPFAKGISGSWIIFNKPPELNAQHAGFLLGLGLNGHLKRLEEWHIYNYLGPKHPLTSIGLLIGMAASLRGTMDNKLTKVLSVHAVALLPQGANDLNVPTMVQTAGLIGIGLLYLESQHRRMSEVLLSQITASVLQNDTEQVHEGYRLAAGIALGFVNLGKGDDLRGLNDTHVIDKLMALAIAMKDYHPVQESGKSCCGAIMALAFIYLKTENVNVANKLKLPETEQMLDYIRPDLLFLRCLAKNLIMWNEISCTDTWVASQMPSSVAHKYMSGNGHEVAFEHLDGDQLTYFNVLGGACLSMALKFASSHNLEARDTILKYLDKVMQLSAKPALNYDQKIAYKGCVNLQNILALCASVIMAASGDLEVFRRLRVLHNDTNKKMGFGCFMAINTALGFLFLGGGQYAFDSSPFAIACLVTSLYPIYPTENSEYEIHLQALRHFWALAIQPRCLIVRDISTGRPCKIPVAINMKDDSVIESISPCLLPDINEILTLKTNSSAHFEVILDFSLNSEVLEKFKQSLTLYVEKSNNHSVLKPNVRSVLQNYSQPVRPEEDTTDILSPQMLDNLDEKVKAAWYRENTNHVESDLRSSSVRSGLSVFNIIDNQLELINNAQTPKSVEDIWNLKLLFEYANHIARNNKLNYISLEFIEGLKHKLWRVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCV3</accession>
    <name>A0A1D8PCV3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA splicing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C102900CA</name>
        <name evidence="3" type="ordered locus">orf19.10497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721479.2">
        <property type="nucleotide sequence ID" value="XM_716386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCV3"/>
    <dbReference type="SMR" id="A0A1D8PCV3"/>
    <dbReference type="STRING" id="237561.A0A1D8PCV3"/>
    <dbReference type="GeneID" id="3636869"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102900CA"/>
    <dbReference type="CGD" id="CAL0000199681">
        <property type="gene designation" value="orf19.10497"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02900C_A"/>
    <dbReference type="eggNOG" id="KOG2184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCV3"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000199681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW25971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="725" mass="83884" checksum="F24F197889DDD9BA" modified="2017-01-18" version="1">MPGNVHNSDFSFKKSDSFNEFNTKNTMSMGSMMMAAIYDEYSDIEEEDQEEEEEAEEKQADQPNSQPFYEGKLNDDTSDNFQKYGIGAKLLMKMGYQKGKGLGVNQEGIINPIETKLRPKGLGVGAVKEKADNNYSDSDKDDLAIDFENKSTKTTASSLSDKLYDTILRFEKLNVNIPSHVKHFLDQRLSLSDESFVSKAEVLLGSLNDIYGEVTKIIDRENIIDYSIKELEKTNESTAIENLQKINQILRTFSSSEITYEEASKMILTDFKSEPSAALAYLSLRRDQLEQLTDVAFSDLSCQKEKVIPILHSIRNEFRQFSTEVSTAHLDKYLYNKYSKIIKKILYCAPTDDEDEYKDISNHEVLLSVLSLWESSPIFVFQDKRMTQLATNIIVPYLRSELNILENDNSTMYSLPEYLLDYIAIFCNDELGTFEQVFTEYVDRYQNFLDVEAPSSLWNFLTSERKVEQVFTIIDEFNHNWAPAVTKFLPRKIEKFYNTFFRSFAKWLEGISFGGADDDITRVDNAFVLLKYVEHKDLLSLLQFRIFNRWLQTFLQSFTNEPHNVPKWYSFWYSYFANKLQECDNITSETINWYLNKALDIIEAKFETSVCESVPKLNGKMLPNCEELINNSRNIKSTVNGIPSYQLITSFKDVVSQFCLQNNILMKPLKDELSLQKGFPVYQFSQNDLSNKKICGYIDDDVLWVGKIDDQEFVPINLENLTNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCX5</accession>
    <name>A0A1D8PCX5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C102970WA</name>
        <name evidence="3" type="ordered locus">orf19.10505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <begin position="61"/>
            <end position="325"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
    <sequence length="421" mass="48119" checksum="8C8BB3B50D14A275" modified="2017-01-18" version="1">MSNPIVPFGKQFRAKYFTNMDDEVFPVNHGSYGLTPTPVLEKYLDLIVKNASYTDKFMKYGIKDSYVESLKAVGRVLNCDYHNLAFVDNATSGVNTILRSYPLKKGDKLVIQSTVYGACGNTVKFLHDRYGVEFIVVDLNYPITDEEILSKFERVFVEEKPKLCMFDTISSMPGVVFPYEKMTKLCKKYSVLSLIDGAHGIGCIPQDLGNLKPDFYVTNLHKWFYIPFGCAVLYIDPKHHNVVHTLPISHSYLEDHVKLSDGDQKNRLIDRFFLYGTKNFASIQVIPEAIKFRSEVCGGETKIYDYCHGLAKQVGELVSRKWGTSYLDQKGSTLISTMVTVEVPTQDYPEIVKNWSVIDHHVYNKMFDRKAYTPCIAHNGKLFARFSCQVYNELSDYDYASDVVLETLKEVASEQYKKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCY1</accession>
    <name>A0A1D8PCY1_CANAL</name>
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        <name evidence="17" type="ordered locus">CAALFM_C103070CA</name>
        <name evidence="16" type="ordered locus">orf19.10518</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1D8PCY1">
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    <dbReference type="GeneID" id="3636922"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103070CA"/>
    <dbReference type="CGD" id="CAL0000190220">
        <property type="gene designation" value="ORC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03070C_A"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PCY1"/>
    <dbReference type="OMA" id="FFNWPTY"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04720">
        <property type="entry name" value="BAH_Orc1p_Yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000274">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Origin recognition complex subunit 1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="60"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="223"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00062293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000190220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW25988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="805" mass="91194" checksum="774069A99204CA44" modified="2017-01-18" version="1">MNKLPKGWNFTIVDDNADSTNSENIQGKRPRRSRTSVQRSDGASPIIRDNIVLIRTDDNEEFKVGDTIEITQGKGPEDPTTEYGLITEIKFGNSEFIEVIVDWFIRSSEIVGMPNDFFADNELLLTPFRSEVKFIDFIRPINVLSESQFADVVIDESNSHSTFLVKRATDNEGNFSDIFDYKDFSGKVLENPKKCAIQVKELISTTVQKELLKEFSKEQRKKKANKVSTTGRVTRFNKRKESVSTKAIKPENKQVRIEIDNDVLSDQSEEKQEESDYNEAEDANSALESDEENISQESEDSEVEYSTKKKLKNKKLSRRSKAAATPSPKRKLQKKDIEDIYSVVTPTKRMKLGKDDRDSLPVFLSPTKSVPSEFTDPKSVAFKEVKQRLHTSQKLNALPGREDEFAMIYMNLESAVNEKTGCCVYVCGVPGMGKTATIKDVVEQMTYSSERGEMEQFSYLELNGLKLLSPTVAYEALWHHISGDKVSASNAALLLEEYFKREDHKRKPLVILMDEFDQIATKKQNVMYNFFNWPTYSTSKLIVIAVANTMDLPERMLTNKIASRLGLRRIQFRGYTFQQLGDIITHRLEMITKNNRRKVVITSDAIGFASRKVASVSGDARRALTICRRAVEIAEKEYLENKKGEDDSGPYQVLISHISTAINETVNSPLSKYIASLPFASKLVLASLLRRSRRTGLAENSLGDIIDEMRNSFAMATHSEEQGSDELNMQDVLYSDKTFTATNETAPILNLRIHFFKQIVTSLVEAGIIIQQNSPGERSRLVKLDVPEEEVVSVFKKDNAISQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDD8</accession>
    <name>A0A1D8PDD8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tco89p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">TCO89</name>
        <name evidence="3" type="ordered locus">CAALFM_C104810WA</name>
        <name evidence="2" type="ordered locus">orf19.8381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713571.2">
        <property type="nucleotide sequence ID" value="XM_708478.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDD8"/>
    <dbReference type="FunCoup" id="A0A1D8PDD8">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDD8"/>
    <dbReference type="GeneID" id="3644788"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104810WA"/>
    <dbReference type="CGD" id="CAL0000194863">
        <property type="gene designation" value="TCO89"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04810W_A"/>
    <dbReference type="eggNOG" id="ENOG502QR2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDD8"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071285">
        <property type="term" value="P:cellular response to lithium ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018857">
        <property type="entry name" value="TORC1_cplx_su_TCO89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="40"/>
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    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
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            <end position="690"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000194863"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="708" mass="78297" checksum="B55C2863523E9CEF" modified="2017-01-18" version="1">MSAQSTPKKEYSNDSRPQSTENDTARSKRGGKDSQPPPFHNSTVTRSSLPNNPRPASTGNIPRNTSTPSLNKKQANRLKTHNRSLSHNKSLTKLSTSTGATARPHLNRSKSTEVLLKSRQGGALKRNSRSLTKMTALQPMTKTTSSPTLPTHKSTTSLKNINSTCSIGLKSSAHKGKAILQLNDDDADYEDVENLSNDEDTGENNAPVPERFDSQDTISTTHSQDEQNIPSLYEQINRILPEPTPASEEPPKFKDKLEVVEEGNTIDSKVNTSHPELGSSTKSSTDDFSQANNFYSGSLLLSQSTGLVRKIDPKHSANLKMTEAYPAMPSDEALNSTAISGISFKANPMELNNAAEPVTTSKNVSQNNSYQPDQTIFNNLQRTNNQYLMNKKQQQQQQQQQQQQKTQQKSQQKQQQVKPLSPAGTAINNGTNNFSDFLRTNNSTSSADSQYGHNIETRTQQRLWLQRESSLMDVTNLDANRMSNFSNLSLNNLMFSHNYNNQSQANIRDLQYSGSVPQQHQPLTPMTPATPGVGNNGSYPGSDVNGNQGLLNLVQGTLPHTVQTKIEFERLNREYLNVRRHANPMGESLKRLESYSGKELKVSKTRKGDKSTTDANASTFEEFSPTFHEKETEISNTLSKLWQDAIVSSSSSSAARPTQPATQHHPTNQRSINPRLASYNQNYNNSRQNQAPNTRAVKLAPIQTTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDS7</accession>
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        <recommendedName>
            <fullName evidence="15">Calcium permeable stress-gated cation channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C106270WA</name>
        <name evidence="12" type="ordered locus">orf19.9382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710874.1">
        <property type="nucleotide sequence ID" value="XM_705782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDS7"/>
    <dbReference type="SMR" id="A0A1D8PDS7"/>
    <dbReference type="STRING" id="237561.A0A1D8PDS7"/>
    <dbReference type="GeneID" id="3647523"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106270WA"/>
    <dbReference type="CGD" id="CAL0000193197">
        <property type="gene designation" value="orf19.9382"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06270W_A"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDS7"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="222"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="411"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000193197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW26288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="105547" checksum="516DB3646AB0CB69" modified="2017-01-18" version="1">MLLLDILSIGWQIIIQTGTNGLGEDYTNGDNDGKKPDPIHSVGPQRVFTTQLVLTLIAGMFSFLLFCMLRFKWPHIYAVRTLRQPRNNSHILRPLPNNLFGWIKVVYKITDEEIIACSGLDTFVYLRFFKMGIKIFLILSISAIFVLSPIRYYFTGNYDKENIMTKPNQPPDINYDFPSFYWVYPIFTYVFSIVVFYYLFEFTTTILRTRQKYLASQSSITDRTIKLDGIPKRLLQREKLKKFIEDLGIGKVLDVKLIYNWTPLEDLLHKRQELMNNLECIYTSMYKMDIDIYNQHEVPAVNPIWSEPLDKPQLNELANKYTQELIELDGEIKHMQGKFDSDLSTIDVKENREFKQVPSAFITMDSVASAQMAAQTILDPRVYKLIASLAPAPKDIIWENLKLTYFERKIKSYFITLVIVLSYGFIIFLVIPLTSLLDLKTISKFWPALGEFIGQSKWLTTFVTGILPPLLFTLLNFSFPYFYQYLSQLQGYTSNSDVELSTLSKNFFFIFFNLFLIYVAAGTFWDYMSYISDTTKIAVQLATSLRRMALFYVDLILLQGLTMFPVKLLQVSDFFLLNVLGKLFYFKRLILKTPRDYRSYYFTPQIFDFGINLPQHILIFMIILIYSVVSTKIVTCGLIYFILGLFVYKYQLVYNFVHPPHSTGKVWPMIFRRVILGLIIFQLFMCGTLALESAILLSILCTPLIFITMIILWNFEKYYVPLNTFIALRAILNPYDFEKVFDQDDQSFSSTSNANSNDESDTSAILDDLDLDLDLENDPIDESSCLLENGGDNGNGNDHGSNGEINNGSITKSSRQNNGEPTISRRKSTLDEEREEFTDYTYPGLIDPLDGPWVGFTGNFVKMIEYKSLRLQQQALLEEGRNVRNENEAAIGTTFINEQELVVNKKLSVSEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE62</accession>
    <name>A0A1D8PE62_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C107490CA</name>
        <name evidence="9" type="ordered locus">orf19.10314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711738.2">
        <property type="nucleotide sequence ID" value="XM_706646.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE62"/>
    <dbReference type="SMR" id="A0A1D8PE62"/>
    <dbReference type="FunCoup" id="A0A1D8PE62">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PE62"/>
    <dbReference type="GeneID" id="3646666"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107490CA"/>
    <dbReference type="CGD" id="CAL0000183205">
        <property type="gene designation" value="orf19.10314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07490C_A"/>
    <dbReference type="eggNOG" id="KOG1625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE62"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="8">
        <location>
            <begin position="216"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="353"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000183205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="664" mass="74630" checksum="86883462AC8B5A66" modified="2017-01-18" version="1">MTVTDEFKKQVSKTFGPKTDLSDDEYIKLQTLLDLFNKSMDDIFVEWESFNITEVKEDLDLNLSNLIRFQGYLQTKLAKNSTPVSKKTRDTIGSTSNRKQFRTVDNHHLTPQLKKRKFEDNTPEFKTPAGIPVSSPTTDYETANNTFVGLTTNGTPTTTTAKTTPSNSLLETLNPQIDEITIDQLPEGKTFRLSTNFDASKFKFRTMQMKLLESADVLDDQIDRMISLYQDQNKTADLQFGNPCMSTQSDILCCGRIVPDNPLYDKEILNSTSLFLETSRISGIGQRIPLDLSNLSNYSFFPGQIVVLKGKNPSGKSFIVEQNMPLPQLGAPVTSSEELKEFQTLQNNQGLKVLIASGPFSNSNKLNYDKLDKLVDLINTKILPQVVILNGPFLDIGNKVVESGEIIIDSDQSQPQPKTLDDLFKAIVTPVLKKIDSKIQVILYPNLRDTCIKHCSYPQDSFDRKKLGLPKNFKVFPNPSGFSINEVLIGNSNLDIFKDLRDIYKEDTAIISNNRFERIVKHIFEQRRYYPIFPGSIKTEPKQKCTELLNGAQGEYLDGIAVGGSSLETPYLGLSELGDSLPDVLILPSELKYFAKVIQGVIVINPGIFIKPSKDPNREEGSYAVVNIQPPNFDAEDNIEAIDDTNTLYYHNVNKRSRVDIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEF0</accession>
    <name>A0A1D8PEF0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 13">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">HEM14</name>
        <name evidence="17" type="ordered locus">CAALFM_C108880WA</name>
        <name evidence="16" type="ordered locus">orf19.12209</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
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        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
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        <text evidence="3 13">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
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        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
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        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6 13" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 13" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367069"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000182679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="531" mass="59621" checksum="4896DBA64CA2BC4E" modified="2017-01-18" version="1">MTLTTLPQNARVAVLGAGISGLTFTYFLSKLRPDLQFTIFEKSKRPGGWMSSPKLHVNNTNESILFEKGPRTLRGVKDGTLLMLDILRKLDLDSQIEVINEKCNANKKYILDSSGEIIQVPNSIGTTIEFLKNVKCVDRKLITGIIKEPFVKPIKEDETIEQFFKRRLGSTVLTDNVASSIIHGIYAGDVGKLSIKSIMSFMKDIENQSGSIVKHIFKSLYSTKKKEEPQLSQELQTYNQLMSPKAELLTLQKTLKQYPMIKLHDGMETLPKYLAEYLINNTNTKIEYNTSIQDIDAVTGKINGESYDHIRSTINTHDLAKTLPTTDPLVPELKSIEYVSIFLTNVYSRSSNLIPKGKPGFGFLSPRYGNVWKNPDALLGTIYDSDIENNVEGLFVDTKPVHNPNNKITIMMGGHYYTNWTIPSNSVNLKIVKDVLTSKLKVDLSKFNLKVIKDGEPLQIDEINDNDLVISYNFHSNCIPQYNLGYQETKDKVNQLLDKGYKLSFGGTVFADGVGVPDCVLNGFKDALKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PES2</accession>
    <name>A0A1D8PES2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pet100p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">PET100</name>
        <name evidence="12" type="ordered locus">CAALFM_C109960WA</name>
        <name evidence="11" type="ordered locus">orf19.4862.2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330687.1">
        <property type="nucleotide sequence ID" value="XM_019475142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PES2"/>
    <dbReference type="SMR" id="A0A1D8PES2"/>
    <dbReference type="FunCoup" id="A0A1D8PES2">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PES2"/>
    <dbReference type="GeneID" id="30515038"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109960WA"/>
    <dbReference type="CGD" id="CAL0000185665">
        <property type="gene designation" value="PET100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09960W_A"/>
    <dbReference type="eggNOG" id="ENOG502S1QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PES2"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000185665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="107" mass="12644" checksum="2714EB195D141E2D" modified="2017-01-18" version="1">MGFIRAFITRITRTQLETAKFGFYLLSPILVMYYVGLDTDKKFNLPGFWPDPSTLNQIPKEPHEIQAEIARIKRARLEKRKRLEEKARELGISEEDFEEEQQQEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF83</accession>
    <name>A0A1D8PF83_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C111720WA</name>
        <name evidence="2" type="ordered locus">orf19.1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2016-12" db="PDB data bank">
            <title>Crystal structure of the ENTH domain of ENT2 from Candida albicans.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 1-155</scope>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGH6</accession>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="PubMed" id="15123810"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="8 9" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <source>
            <dbReference type="CGD" id="CAL0000179002"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="591" mass="65537" checksum="EBB62B2F074883A1" modified="2017-01-18" version="1">MIEILHNLSQGWTLTLLSSCLCILGTLIILIDDIYYTCLPKFITSKFKIQIKQNYRFLNGSLAFSSGCLIFTSLYRLLPSAHEYLANSNNNNNNNNNNNNHSGHTHNLDENGEGADDNHQWNQFILILSYIMGILICLSFNYILHLLTSESVVHCNHGGDVTTDLHDINGDLENQIGVHHHHQHHHHGDTLFNDNYNGSDGRGDHNKNSNSVTETTPLIDNTKNGVASVPVATARKRKSIIQLILKHDDIEDGSGGECKGYSSAELCTFHNNNNNKISTKLNGDGNECDSNISEELDGGHPGVEEEGEGVVVQQTQQLHYCEIPTLSQELIENNNNNNNNNNVNAYSYPPENDIDHFSNTINNFDGNDANNNNNNNIDMGPLYSIHSKSSHSLHSHAHSHAHSHARSHRSHKIDHHHHVNSPLSRLLTIGIQTTLAITLHKLPEGFITYITSETNPQLGISIFISLLIHNFTEGFSMCLPLYYSMNNSTKYPKLKAIIISSTLGGLSQPLGAILGYFFLLFNSHNKNSDNDYDVDKLNRIFGITMAITSGFLTVISLSMYGSSVSFGGNINFVMTWCIIGISVIGITSVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PGI2_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C202050CA</name>
        <name evidence="2" type="ordered locus">orf19.9097</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722566.2">
        <property type="nucleotide sequence ID" value="XM_717473.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGI2"/>
    <dbReference type="STRING" id="237561.A0A1D8PGI2"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C202050CA"/>
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        <property type="gene designation" value="orf19.9097"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02050C_A"/>
    <dbReference type="eggNOG" id="ENOG502RPQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGI2"/>
    <dbReference type="OrthoDB" id="4089867at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
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            <begin position="120"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="539"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="802"/>
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        </location>
    </feature>
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            <begin position="1020"/>
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        </location>
    </feature>
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            <end position="311"/>
        </location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AOW27246.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115361" checksum="E0E3462BD184828B" modified="2017-01-18" version="1">MSTKVAQGKSKDDLSIPEGGLNSIPLNSDRRTRSNSPVKNRYSLPPNLTDYKLPSIPRMDDDIKSIMSSTSFNQERLKQAAKSPIAKRLHIIASNSNSPNNGGKYTIPIPFTLKLPPKLSSVNTTRETSAASSVVSSPHGSRAGSPTRSMESSRSNSPSKTKQSKLVFTRNGYEKVDSSSDSDSDIENSLLNMSLSYQDDLNKRIALSKRTVPPPSVSTNNSKFASKVFSSRNTDELSIIEEVSNCGSRHSSVLSKLNSAKKEADTEAQQQKTVVTPIPIKATAKPSHALISPFNNPQIKDTPSKQQDKSLPKLPTTDIIPPKQETATSDKKLTPGPDRTSVPNFKTHKYNKSLPAIPVHRSTTNGPNKSQVPKSQRETNLNMLTHASDPDKAPKIHKRSFSDESHVSSVSSFSSVGDFMHIARLQAMSPPAEKLRFINFNHGNNQNQLKIQPKSNNVKPNDSTEKLENPKKSETQDSRMLFIPPQNIRNVSSSSTSSFQSSGTSSSWDSLQKSIDITLGSRPDEEIVTKKSIKPTTKVTKILGGNNQSDDGSWSDTSESDSEDENNSNNQITQEYENTKPLNIHKEEVSNDKTVLNLMNVNNTEINRNFYFPNTFENSTNSQEVKDRVPQENNRKARHSFYSSNGQIEIPDLSDKRFSDEYSSIAPSSYNGTTFSEIRTEISVSDVDDESNTNLKIGVPGRDAIKHLKQQYSALGDDSDADYASNITSLYNTGANSDKMQMKPASVQPQLECNLLVPGRRSPAKHARHKSMFNIDFDLGKGKNNSNHSRHKSVDILSEMTTFGKQQSRANTDSRSAGGDLDESAGSKSRINIEQPVAPLVITRKPSSESKHVNNNIQKEEQNQEQEEILNIKVAEPPKKVDYAVDFKESNSQDDDFGTPFITPRIGSRSIETSSGRNIGAITKSLKPKTRSVTSKGEDSDSETESVVIDLTKDKYDVVHVIGRKDSTRSYKSTTETINGKNVEVVLVEDEDEDEEENEEIYDELMSIYSKYRNDSWLFRNNSTTSSTASFSSRSSSTLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGN5</accession>
    <name>A0A1D8PGN5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Low-affinity Zn(2+) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">ZRT2</name>
        <name evidence="10" type="ordered locus">CAALFM_C202590WA</name>
        <name evidence="9" type="ordered locus">orf19.9158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722627.2">
        <property type="nucleotide sequence ID" value="XM_717534.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGN5"/>
    <dbReference type="FunCoup" id="A0A1D8PGN5">
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="2 3" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="419" mass="47727" checksum="250578697299247D" modified="2017-01-18" version="1">MFFLIQLQPSKTYIQIMLRPIRWNPRMVGIRSFSITRLNFNTNNNTRASPSSSSLFAYIHDYNTLLEKVKSTITSNSSESDILEAMNGIKNLQNNYPIQDQINDTSKLTKQSISIINTIFKNDDDRKFSSKLLHDILILNLPSSLNIKVIKHYYKSNPTDVISKEVALIPLRNAIFNAEFMKAIKLTDLTVGHENYINHMNQILKSGVIKLISTAIIVTLFTKLGVSSLIDAGVISQSWQSIGAINSIILTYLINSSFFISIVKLGRTLINAGGDYLTWQKGTFYTHWFKHADEMLFSSKIIEADRELNQGESNPDIIEELCRRPPDDRDSMRGLKPGVDRDGNKIRLLQLKDDLNKVTFQAYWMTGGDGFEWIEPDQDPADIQWRKHLELYNKPALKQGEFGALGWADDLIQKSTKDV</sequence>
</entry>
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    <name>A0A1D8PHI7_CANAL</name>
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        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
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        <name evidence="9" type="ordered locus">CAALFM_C205750WA</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707722.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PHI7"/>
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    <dbReference type="STRING" id="237561.A0A1D8PHI7"/>
    <dbReference type="GeneID" id="3645577"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205750WA"/>
    <dbReference type="CGD" id="CAL0000191069">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05750W_A"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHI7"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:maturation of 5.8S rRNA"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="416" mass="48541" checksum="0F1F9273B0F70932" modified="2017-01-18" version="1">MSEEIISKKPSKPQASRKGKRAWRKNIDIQEIEQNLQDKRDEEIVLGKEVTDDFVIDDTPSSKSGKLPKKLKTKEILTNKSKIPALTNQRHQKKGENTIQGVKKTDLLRLIQLNGGKFKSEDKYVNRLEQDGIVNGSSQDLWDDTDNNEKKKIPDFMKSTAEVTKASVVPKTLKVNPIKITSNELTDKKIHAGKSYNPSLESWKELINQEYDIEYKRELTRQQIEEHRNKIKELMITLDDNMLSDSDDDEDDEDNDKVEEEEQLNANGEKDYSLSINKPNKIKIKTKTKRNKELKHKERVKLEQQIKDLKKQLKDLSNLDEILEKQAVKDQSQPNEKKRKRREKLFKYSLVETPLEVKLSDELSGNLKNLKPEGNLYYDQMLSLQSSGKIESRVPVNKKRKYTKKITEKWTYKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="326" mass="37537" checksum="6194D1819163EDB4" modified="2017-01-18" version="1">MIQNVTRDKLYPEGKPVDLEEEFGVEKIGPNLYRGKKPIAKPDKRSRGAFGGFLAGQALVVAIESVPKEFKPHSFHSYFVKAVDDLAPLEWAVDEVSNGRNYANRSLKAYQYEDIVYTANVSLTKKISTKKAIEETGVKPFEFQTPKHEWFNRHKLEDLPVADVNSRLLAYHKFFPEVVSLEDTREEDNISPAERQLSWYFKWGIENEGDFHQPLANLDSKYQYVGMASLTDTVYLTRLLRILRIEDADHSQFIHYFSVSLDHTIYFHDDDFDVTKWMSFTFKVTRFSHNRALCQGEVYNDKGVHVATIVQEGLVMLNGLEEGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711481.2">
        <property type="nucleotide sequence ID" value="XM_706389.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHM7"/>
    <dbReference type="SMR" id="A0A1D8PHM7"/>
    <dbReference type="STRING" id="237561.A0A1D8PHM7"/>
    <dbReference type="GeneID" id="3646921"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206270WA"/>
    <dbReference type="CGD" id="CAL0000182815">
        <property type="gene designation" value="orf19.12944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06270W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PHM7"/>
    <dbReference type="OrthoDB" id="4084460at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000182815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="398" mass="44594" checksum="78F949A100879D2C" modified="2017-01-18" version="1">MMAISNTVLLVILIITFVLILGIFFLVGFCFASWCPFLCICSKRRKARVALKNILMNRSSSSNLVSQPCKRLNDLENQPVAIERNTDSASNIALKSYPMDSNHSAKICNATQSQICDGNSPNVDETHDSDFKSVLDNFDKSESCISHNFVEESRNESDLMPTLIAHPSQNAESIVQSEFDTYSLTLLLQYLIQTSTKPDDQAIRKVSDPFSDNYISVGEKVVIVKSFIGKTDTEFPSLQTGDLLRIIKFIVRDSDDSDEATGSIKSMRMAPKSPTRPRPRSRNQKQKQKQDYQPTSAITLESSNESFSSEIIINKSNPIHKNIYCVGLLLNSYLDFNNDQLNLELKVQETSSEEEEATEDLIKEFPLSIVSLETTVVKSVLAGEVGEEEEEEEQAQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIH0</accession>
    <name>A0A1D8PIH0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">KAR3</name>
        <name evidence="12" type="ordered locus">CAALFM_C209370CA</name>
        <name evidence="11" type="ordered locus">orf19.11581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
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            <end position="683"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <end position="31"/>
        </location>
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    <feature type="binding site" evidence="6">
        <location>
            <begin position="442"/>
            <end position="449"/>
        </location>
        <ligand>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ02</accession>
    <name>A0A1D8PJ02_CANAL</name>
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        <submittedName>
            <fullName evidence="6">Lys144p</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="6" type="ordered locus">CAALFM_C300750WA</name>
        <name evidence="5" type="ordered locus">orf19.12835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AOW28124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_712664.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PJ02"/>
    <dbReference type="STRING" id="237561.A0A1D8PJ02"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PJ02"/>
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    <dbReference type="CGD" id="CAL0000201205">
        <property type="gene designation" value="LYS144"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SPNA">
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000201205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="860" mass="97735" checksum="3ACCB185E0B28B38" modified="2017-01-18" version="1">MGSSSPNPTKSPLGETSQQEATTTTAKPTKKVIKKSKYSRGGCAECRRRKIKCDELKPYCHNCTRLNKLCVYPTKPKFKFETPKTTLNNDNNMSNDQALPNGNNIGNNSVSYQFLHDKSNISNLQIYYNETQKRILNGSNGNNIPNLQQHQQNVIPYIDTGNLGTLPPPHHHRPPTKKFKISDMLSPDNDNQSNTTTTNNNSNNRNAYDFINMDYYNWDTLPITDIQNLFDDASLLVQDSLGLFTALENELNLPINADENNFGENNNNDIQLPILDSSSDKVSSSNSPSTTLSPSSFAVPQKSLSNKKLIEKTLLMHDIQGPHKLYLDKLTKTKLSYHVYPFAESIETNQVLRILLQYSLGSPYLLTAILATSATFQFIETRQMIHKDHQFKYTNISLKYLSEAFPQESNKDIHNSNNSGTTDNANFKMMTKDVEKLLLTILVLTLNFTALAYFQSNNRDGSTGISSVNKNNWKIHLRGVKDLLLKYSKLAHSNNQQYITDGLALAKTWFFAIESVAELNDPLGGTIKYSTKNISSHVDIIKTNQNVLDCSDSSRLWVETGYFNRGKNQDYHDALYRIGMVTNPNLPISTQFNMFLGFSIDVVKLIDEMTKSLDLLRENKPGQLSGTSIANIFTLISRARNNDIVPKVNKETFVIPKESIGHPEYKEFDKLVLPKSCYTHEIINDNSTTTSKDGSSKETIYYSWYDWSEQLHIDSVYMKLFHIKGLMKLPRDHPLVQELKDKVLTSMFFLKDKQQNIVDKEINNDSKIFLESDHYYLHSDLFDTRAIMAQSSYRECIKIANGLLDFEKLELYFQGLIKLGNGSSLLALDNVKRFKQNFIDGKDVEDDVDLAFDSEIIPFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK43</accession>
    <name>RL18_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL18</name>
        <name type="synonym">RPL18B</name>
        <name type="ordered locus">orf19.5982</name>
        <name type="ORF">CAALFM_C305100CA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330871.1">
        <property type="nucleotide sequence ID" value="XM_019475326.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="BL/y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="BL/y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="BL/y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="BL/y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="y=1-186"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
    <dbReference type="PDBsum" id="7Q0R"/>
    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PK43"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PK43"/>
    <dbReference type="FunCoup" id="A0A1D8PK43">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PK43"/>
    <dbReference type="EnsemblFungi" id="C3_05100C_A-T">
        <property type="protein sequence ID" value="C3_05100C_A-T-p1"/>
        <property type="gene ID" value="C3_05100C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635156"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305100CA"/>
    <dbReference type="CGD" id="CAL0000188970">
        <property type="gene designation" value="RPL18"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05100C_A"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PK43"/>
    <dbReference type="OMA" id="IDICHKN"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456490" description="Large ribosomal subunit protein eL18">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="186" mass="20770" checksum="EE74FCC80A9920F9" modified="2017-01-18" version="1">MGRDHTSKQHVRSGHRTAPKSDNVYLQLLVKLYSFLARRTDAPFNKVILKSLFLSKINRPPVSVSRISRALKQKGAAEKTIVVVGTVTDDNRLLEFPKATIAALRFTAGAKDRILKNGGEAITLDQLALRAPKGQNTLIVRGPRNSREAVRHFGFGPHKGKAPRILSKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKP8</accession>
    <name>A0A1D8PKP8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C307140CA</name>
        <name evidence="3" type="ordered locus">orf19.14078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712617.2">
        <property type="nucleotide sequence ID" value="XM_707524.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL54"/>
    <dbReference type="SMR" id="A0A1D8PL54"/>
    <dbReference type="STRING" id="237561.A0A1D8PL54"/>
    <dbReference type="GeneID" id="3645759"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400780CA"/>
    <dbReference type="CGD" id="CAL0000181516">
        <property type="gene designation" value="YPP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00780C_A"/>
    <dbReference type="eggNOG" id="ENOG502QV6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL54"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23270">
        <property type="entry name" value="YPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000181516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123498" checksum="2C2EF6201CD75605" modified="2017-01-18" version="1">MYIESSINDKYIRTLNFGCFPKNVLEFQQSQDYFQQLIFIDYQLQLLIDNEFFQNELLPISLLSENNVSANEKLQQLINYSNSISLNYENTPKSYDEKLYYATLMSHLYYLQDNFFEMSKYLNLVKVSYQARSNNQIETASSASSVSLNQIEFIEYLTTRYYVLFGLSAGNNGVNVWLEYLQNFKSPYNKSQVIANHWLDLLFGKLTFELSQRGTIPFSFINHVKNLSLSKNKLVLIAFSNYLLRPENSNIINPSFKQDYTVFLTTEIEESILVKSQFPNANTANTDESQDVNNFINNLYESLSYVPFNLSILKPSLSKRYLLNATLKTFQSKVILSNLIYTLIDLNEYDEALAVFTTYIDYLEKDEELKDGYIDDILSIIDTFSTCIIHFNPLKSFKSGNKFKHNDDSSVCQHLKKFVTLLQKYLLELQKLIDLTYDEEEDESDKVTTAAGDKIPLSFLYRKYNLNILQSDNTQFIELISKAWHATGYYYYYLSSYESSNQIILQNNISLVLKSYKNCLIVNSTGNVLYLFSYALALANSGSLKPALKLCKFILKKFPESFKTWNLLVLLLSSFDNDNSDVTKPIANHTSMNILPDELTNGNANAHGGDGLTANGGNDTKSKLREPEKFINKALNIAGLYTLKHRQRNIKLTVETKYEILQLKLTQLAVLESIHGSQYMIDYLSEVFVLYHELFEVNLSSSSSNKNAANQSSRQFGASDKWSHRPSFIDPSPNAKKNNPHHNINGKDELQFFDAPKLSIANDADSISDLNKKQSRTGSIIGGVGGSRVEKLKRLSTTISSKEGPISRRGSLLYNSVQQKIRKSDSKNSVNKSFAADTSESPQQHLEDENLHFNQQKLQTYPEEQQISKPSKPEYIKDPPRHQHDNLIERKILQQVWLWTARVFLKVGLIDECEQCIVEAETIYEPNFKTYTALGFLTSKSRKFLSLQEFERSLEILTKKDNSLASHNKFNSKYDYGLTLLGLSKLFLIDDDPKNSLFISTKDLNSGIIRLKNLLEDYSLTWPYGYNNPEIWFYLSKIYEFIDDKILLTKSLWRCIELEDKRPVREFIFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL79</accession>
    <name>A0A1D8PL79_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCA-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">CAALFM_C400880WA</name>
        <name evidence="16" type="ordered locus">orf19.12176</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded. The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA. This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="7"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722770.2">
        <property type="nucleotide sequence ID" value="XM_717677.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL79"/>
    <dbReference type="FunCoup" id="A0A1D8PL79">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL79"/>
    <dbReference type="GeneID" id="3635681"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400880WA"/>
    <dbReference type="CGD" id="CAL0000199196">
        <property type="gene designation" value="orf19.12176"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00880W_A"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL79"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3090.10:FF:000024">
        <property type="entry name" value="tRNA nucleotidyltransferase, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="14">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076038"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000199196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW28879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="531" mass="60909" checksum="42310154D8258CF3" modified="2017-01-18" version="1">MKRPVSNSIVLTTTEEKIRNVLVGYCDYYNKTNNDSLELRITGGWVRDKLLGNESHDIDIAVNHLTGEEFVNGLHDYLRQHEPELSMNHVHTIKMNPEKSKHLETCTTKLFGVDIDFVNLRSEEYTHDSRVPSIEFGTPEQDAVRRDATLNALFYNLNQGEIEDYTKRGLSDLQNGILKTPLAPIKTFLDDPLRIIRLIRFASKFNFVVESETLNAMKEEHNKSALSTKISKERIEIELRKILTSNNPGYGLQLINYVDLASSIFYVPELAKEFDNESLEEARSQLACHMEIASLIYPNFKQTINNSTEKFKNEFAALMTNDDYKNVFWLSVILHPYTNVKSCKPNRDIFNQYLRLGLTSKKSDIAKVSAINMNSAELSRFFSAPELVKRSDIGLYLRKFSEFASLNLIVNALLDCVRKVDQFTQLPKELPVPFPEVGEKILGDENINKVISEIVSRYENLFVQIENWDLTNVHLVKPLIDGTTLSKSLGMKPGPWLRPTIEEILVWQLDNPQSSVDECFEFVKSIIPKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLC1</accession>
    <name>A0A1D8PLC1_CANAL</name>
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        <submittedName>
            <fullName evidence="5">Ubiquitin-ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C401560CA</name>
        <name evidence="4" type="ordered locus">orf19.12099</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW28936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_717608.2"/>
    </dbReference>
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    <dbReference type="PeptideAtlas" id="A0A1D8PLC1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bul1_C"/>
    </dbReference>
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        <property type="entry name" value="Bul1_N"/>
    </dbReference>
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        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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            <begin position="55"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="897"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000193613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLU0</accession>
    <name>A0A1D8PLU0_CANAL</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
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        <name evidence="5" type="ordered locus">orf19.10881</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711593.2">
        <property type="nucleotide sequence ID" value="XM_706501.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLU0"/>
    <dbReference type="SMR" id="A0A1D8PLU0"/>
    <dbReference type="FunCoup" id="A0A1D8PLU0">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLU0"/>
    <dbReference type="GeneID" id="3646813"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403460CA"/>
    <dbReference type="CGD" id="CAL0000175616">
        <property type="gene designation" value="orf19.10881"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03460C_A"/>
    <dbReference type="eggNOG" id="ENOG502QUGB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLU0"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12453">
        <property type="entry name" value="RRM1_RIM4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000861">
        <property type="entry name" value="Rim4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034352">
        <property type="entry name" value="Rim4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="287"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000175616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="623" mass="68394" checksum="60704C09BC5960A2" modified="2017-01-18" version="1">MKLEASSCSSNSSESSTSDLIESFPPLETTVSPKENINSLYSNNQWHDKIDSASSTLSSSNSGKSKEKFTAKLAIESVGGMTASNKASELNSAYVRGRPSACVFVASLCSNMSDDALCVSVTDHFKQWGTLATVKVLRDTCNRPYAFVQYTTDSDSKLAIEKGHNSVLDGRNIRCEAAKVNRTLFVSSKSFLSKSIIRDRLSNFGEIEELLPSTSKGELYNSGVDTRGYKNWFCKFTYRDDAIRAYANLTEEGIYKVDWTQNIDKSNAPRNVNEPEQESLKVKFDKYSIFVGQLSPEVSEDQLSQRFERHGEILDLNLIKRTNNTFAFIKFKRESSAAGAVERENHSMFCGKTMHVQYRETHIHAPIRTRSNYNNGIPLAPPPINLNKKSFQKNDYVKSKGMIEMSKPKFNSYPSNSFNKGFNKLKQFKSFRPGSYEKKFGNTKTESTWHASQLNLKSEVSESSQVEKKASGDIRVPSAPNESRGSGASSRNNSSTSFPPPPPTTTTPGFPLFYYVPADNVNFANSSSANPPPFYNVYPQYYPATAAAAAAAVAAAAAAASATGGANGNLQYDTPGCPPSGVANVVAGSPEFSSIASHPSYGGIANYMYYPNEPEMNINDKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM44</accession>
    <name>A0A1D8PM44_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">CAALFM_C404720WA</name>
        <name evidence="16" type="ordered locus">orf19.11291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717215.2">
        <property type="nucleotide sequence ID" value="XM_712122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM44"/>
    <dbReference type="SMR" id="A0A1D8PM44"/>
    <dbReference type="FunCoup" id="A0A1D8PM44">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM44"/>
    <dbReference type="GeneID" id="3641137"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404720WA"/>
    <dbReference type="CGD" id="CAL0000186217">
        <property type="gene designation" value="orf19.11291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04720W_A"/>
    <dbReference type="eggNOG" id="KOG0089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM44"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="14">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="15">
        <location>
            <begin position="145"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000186217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW29216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="323" mass="36136" checksum="4CA14C5251152C42" modified="2017-01-18" version="1">MSKPAGRTILASTIAKPFQEEVTKAVKQLNFTPKLVGLLSNEDPAAKMYANWTGKTCESLGFKYELLEVNKNDLETALIKANKDDSVNGIMVYFPVFGDKQDQYLQQLISPEKDVEGLNFLYYHNLYHNVRFLDPPQNQQKSILPCTPLAMVKILEYLGVYNTILHYGNRLYGKKVLIVNRSEIVGRPLAALLANDGATVYSVDINNIQQFTRGDDLSEQRHKVVDLSPEEYTLEKLAPQCDVIITGVPSENYKFPSDLVSHGTVVINFASSKNFNDDVKLRAGLYVPSIGKVTIAILLRNLLRLIHNKQIRQGEVSDATSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMC4</accession>
    <name>A0A1D8PMC4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fgr6-10p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">FGR6-10</name>
        <name evidence="3" type="ordered locus">CAALFM_C405530WA</name>
        <name evidence="2" type="ordered locus">orf19.8819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000191763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29392.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16649" checksum="1DC46105D334EE62" modified="2017-01-18" version="1">MSLRVVPSSTNKESSVNTTKFGQPAEHAPALQDSLRSQEGPLNIASKINNRHPLESQVTNWEKTQEENRMETYRRIFGAGAPIKRAMELEIVESSSFRPSLLGGVDSMHKDILLNKDSSVDWEDVYPGGFANGDNVKDFHSEMEKQMGI</sequence>
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        <recommendedName>
            <fullName>Amino-acid permease GAP3</fullName>
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    <gene>
        <name type="primary">HIP1</name>
        <name evidence="8" type="synonym">GAP3</name>
        <name type="ordered locus">CAALFM_C501800CA</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Eukaryot. Cell" volume="4" first="1687" last="1696">
            <title>Global role of the protein kinase Gcn2 in the human pathogen Candida albicans.</title>
            <authorList>
                <person name="Tournu H."/>
                <person name="Tripathi G."/>
                <person name="Bertram G."/>
                <person name="Macaskill S."/>
                <person name="Mavor A."/>
                <person name="Walker L."/>
                <person name="Odds F.C."/>
                <person name="Gow N.A."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="16215176"/>
            <dbReference type="DOI" id="10.1128/EC.4.10.1687-1696.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Microbiology" volume="151" first="3381" last="3394">
            <title>Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans.</title>
            <authorList>
                <person name="Kunze D."/>
                <person name="Melzer I."/>
                <person name="Bennett D."/>
                <person name="Sanglard D."/>
                <person name="MacCallum D."/>
                <person name="Norskau J."/>
                <person name="Coleman D.C."/>
                <person name="Odds F.C."/>
                <person name="Schafer W."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="16207920"/>
            <dbReference type="DOI" id="10.1099/mic.0.28353-0"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1219" last="1229">
            <title>The Candida albicans GAP gene family encodes permeases involved in general and specific amino acid uptake and sensing.</title>
            <authorList>
                <person name="Kraidlova L."/>
                <person name="Van Zeebroeck G."/>
                <person name="Van Dijck P."/>
                <person name="Sychrova H."/>
            </authorList>
            <dbReference type="PubMed" id="21764911"/>
            <dbReference type="DOI" id="10.1128/EC.05026-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2016" name="MSphere" volume="1" first="0" last="0">
            <title>Characterization of the Candida albicans amino acid permease family: Gap2 is the only general amino acid permease and Gap4 is an S-adenosylmethionine (SAM) transporter required for SAM-induced morphogenesis.</title>
            <authorList>
                <person name="Kraidlova L."/>
                <person name="Schrevens S."/>
                <person name="Tournu H."/>
                <person name="Van Zeebroeck G."/>
                <person name="Sychrova H."/>
                <person name="Van Dijck P."/>
            </authorList>
            <dbReference type="PubMed" id="28028545"/>
            <dbReference type="DOI" id="10.1128/MSphere.00284-16"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Amino-acid permease that is able to transport phenylalanine (PubMed:21764911, PubMed:28028545).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 6 7">Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545). Expression is also regulated by PLC1 and GCN4 (PubMed:16207920, PubMed:16215176). Expression is induced during development of biofilm (PubMed:22265407).</text>
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        <text evidence="9">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="gene designation" value="LEU3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C5_02180C_A"/>
    <dbReference type="eggNOG" id="ENOG502QPVP">
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:positive regulation of L-leucine biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAL4"/>
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        <property type="entry name" value="C6 transcription factor (Leu3)"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
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        </location>
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            <begin position="840"/>
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            <begin position="40"/>
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            <begin position="59"/>
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    </feature>
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            <begin position="740"/>
            <end position="759"/>
        </location>
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            <begin position="778"/>
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        </location>
    </feature>
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        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000199400"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="984" mass="110890" checksum="1B74E696A1D927E4" modified="2017-01-18" version="1">MNNNVASSQNSGKSSLDNLVHIASNMSQEFRLPNRPSIPPNQSLSQTPLNQQPASEYNSATSTPSPSMATGSKTKRSKKMACVECRQQKSRCDAFEKRPDPCTRCAKKGLHCDVKSDYKRTYKRARMAQIEKEFEELKKTLTTTQAAELLTKFPSLSSASPDTNPQEETSQIQVKIEPGTSNDTTQGIAGVGVAKTTSNVDLPQHSTKAVEGAYTQQNSTKNTQFTPYRISSHNSSETSQSIPNTPSITRQVESNTRSQIPLAQQEKKVELLDSSLICEEKSVDDISLMPETIKKLYLEYFERYHPILPVVDVSLGPERIYRLCPALFWVIMFVSLRRFPDNSSKSLLVRLSPIVKGILAEIMISPITRYNPIEEDEPIYNVSSVYSVQAFLLYSYWPPITSSLSADSSYNTVGTAFLQAIRIGLHTPTLVNTSEMNKDEKTKHQLTMTHEQLKTWIFCNIASQTIATAFGFPACTQFESSMWFYNQPGSSIIIPRNLQLMMEIAQFEDQMAKALNSNPMDPCGLIDASERLPLLKLLSKRLDTIEITLKNEMLQPSDRRFRVFEILSARVHLLSYYFMDTVRIAQFELQKGLIRLYNAAIALISHTSECQAEDKKFVKYLPGVYLLNLWQAGCIIGKLIHSSLKKFIDVGTGKQSYESVITFTATASILKHDMAYRSSGITRNMWQLFRELDAKKMNSLSIDIRNRMSASVFFDCLKLLRAQVGITKLTTKTDESHPADDDEAIEESQEEVEDEDDQQLAEMGNEKAAPSEDEKNGSLHNVSQKSTPNSTTSSRVRRARTLSNNMDAESKTRKIIRTIPLDPEPISIGASKRSSIFKVVNSSTDSSPIMKSDVSTPNSNRINDHQTRTQTYNPSHVGKQYSQQSPHISSKQTVQSSQYQHHQQQQQPQQLQQHQYEQILQSDNRSYQPAQNISEAPLSQFSAFAFNESPIQLGLENLDIDNFDHDMLWKDVDSVMNDFGFHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNE2</accession>
    <name>A0A1D8PNE2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C502350CA</name>
        <name evidence="3" type="ordered locus">orf19.11718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720552.1">
        <property type="nucleotide sequence ID" value="XM_715459.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PNE2"/>
    <dbReference type="FunCoup" id="A0A1D8PNE2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNE2"/>
    <dbReference type="GeneID" id="3637791"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502350CA"/>
    <dbReference type="CGD" id="CAL0000199643">
        <property type="gene designation" value="orf19.11718"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02350C_A"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNE2"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000199643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="292" mass="32865" checksum="C3B2B37B4E2D568A" modified="2017-01-18" version="1">MNCKSMTMSKQQPCHSNPTKTHIQKNSRKVQRGGARGLGGGNRISQDKETQRETSINGNDAKPIPIPSNYRYDEHSMEAKELWSLVPVNSKYSNRMGSIPNQKFPINEVFAIKALEFFQGDVYKVVELISELSSSPISSNKQSKQFNEKRQPFDVKINKPSSPSSTLEYQSDNVSFNSDDEQQLFNKYLKTGTVDFHGFTVVEAMKLVPLILNHWWNQELIHRQSIGQLQKFGNSASLGSVLIITGRGIHSTGGVSTIKASVNRYLINNNYIFNQPTSGSFEITGKRMNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPD9</accession>
    <name>A0A1D8PPD9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C600630WA</name>
        <name evidence="3" type="ordered locus">orf19.11672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <begin position="54"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PPL1_CANAL</name>
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        <submittedName>
            <fullName evidence="7">Histone acetyltransferase</fullName>
        </submittedName>
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        <name evidence="6 7" type="primary">TRA1</name>
        <name evidence="7" type="ordered locus">CAALFM_C601320WA</name>
        <name evidence="6" type="ordered locus">orf19.7783</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
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        <property type="entry name" value="FATC_dom"/>
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        <property type="entry name" value="PIK-rel_kinase_FAT"/>
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    </dbReference>
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        <property type="entry name" value="Tra1_ring"/>
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    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2647"/>
            <end position="3202"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3457"/>
            <end position="3794"/>
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    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3789"/>
            <end position="3821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="545"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="3222"/>
            <end position="3281"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="536"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2062"/>
            <end position="2075"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="3235"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3236"/>
            <end position="3260"/>
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        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000175793"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30073.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="3821" mass="437987" checksum="B91DFEE8DFF98390" modified="2017-01-18" version="1">MPYTEQLDAFVTRLNDSGSDYTKKHSILSELLDTIESFNGATEYEYFLKNLVPIFIKDLEQVPISFISTSPQHKLRNSILEIIHRSIMNDTFQPFSEQILDALVKTLIEENEDNGVLCMKIITSLHKAYKNKLNEKVQPFVDIIGSIYDNMDKTVHDVFSDDDTQGTASATVGDTSTDVKEDSPAPTSGFNEETPTKKLNKAMFSFKTLAECPITMVSLYQSYKQLVSTSLPKFLPKIIHILELQVDKQKQFREESENKIVTSISPDIKNRQAFSDFILGQVKAASFLAYVFIRGYASQHLKPEESKCVPDVILRLLQDCPAELSIARKELLHATRHILSTPFRTQFIPKLELLFNEKILIGDGLTSYETLRPLAYSTVADFIHNVRNELTPAQIWSTVNIYCDLLKDDSLALTVQIMSAKLLLNLVEKIMKLPNKLEGRQLFLIIIDSYAKRFASLNRKYNYIISKHNEFENKKASKERKAKKAIERYSSKIEPEEPEEQQQEKQQKEEQKSDNANEDMMDIDKPNQDEVSEKQETPSPLDMFNIDTHSPIAAIPVSNNTDVLKDARYLFRTLMTFLKSVIFGLKNCNPPVPPQPTSSDPNKPRQQVNYDKWNDSAKLIAYEEVNILRALFRGGISCLRFFSITKSKPPITNKTIDFSTGGPNLPITSSKEEKDLMEIFATIFIHIDPASFNEIVSSELPFMFESMLENAALLHLPQFFLASEVTSANFSGILISFLRDNLEQLGEADLIKSNILTRLFKLCFMSVNIFPTTNEGVLLPHLNHLILESLRLGTKAEEPIVYSYLVRILFRSISGGRFENLYKEIMPILPVLLENLNKMITNARRPYERDIYVELCLTVPVRLSVLVPHLNYLTRPLVYALNGSQELVSQGLRTFELCVDNLTAEYFDPMIEPVIDEIMAALWKHLEPVPYHHQHSHTAIRILGKLGGRNHRNFKPCNKLVTQSDLDQEVKALFEIHGLKGSVPVSITPGVESAVKLLEDPRLKIHYKISAFKYLANILKLLINTTPIPENFPQYISESIEYLKQEKNEDINIELAPSDIKDNEKLDRQQQLFSKLLEILFFSVSIPDLKDEASELIDGITTHFTFLRLTTSVIEKVKKERQFSINENEGKAYINENVFFNSLNYALSFWDKNVRQKGIDCIQKIYDTTVVIFGSDENALYSPVFRSMFYKFTHCCYNEYYHAKLGGILGLKTMFQNLKIPANWFSKRQFELVRSIFFILRDTPETAPFEVRESAKTLVLDLLKACNTDVTKETVTEKSFQTLVGAFVYDLASPTPMVREVAQKCLTVLSETTGVGIATMIDPCKHLLLAPIFGKPLRALPFPMQIGNIDAITFCLNLPDTFLTFNEELNRLLLEALALVDAEDESLANVHRLSEYRTSKQLIELRVVCIKLLSLALTKPDFSLGSLAEARIRILGVFFKALCNKSTEIINAAHHGLAASLQENAKLPKELLQNGLRPMLMNLSDHKKLTVSGLEALARLLELLISYFRVEIGRKLLDHLMAWAQINTLRQIAGQDLTNNHTVQIVMAILNIFHLLPAKAYTFMEEIINTLQYLEGHLDRHKDSPFRQPVSKFLNRFAENCIEYLIVNFKNRKLGNMLAAITGMDGCENLRKISREKLTVFIDDVKNESNKEIKIIKFANLVDLVDAISKHEHSWFDEQKPLLLLLSETVEEISDTRTTAEFSSVHFQSDQAIEKLHELIVGFLKRNPKEVDLMLAVVNRDCKLKLQVPAVVEDYIFNDIVSSNEIDIREEYLKKSIEFASDEVSNLKAKIFFLKKVFNPIFIYESVNKGSVDTFFTNTKPEWLEKLNDSIWKSTKDIITNHTSGSMDSYRYALLEVTALLLKLASKYLGDLRKDIIKFSWNYIKLEDNITKQVAYVTTSYFISVYETPAKLTTQVFVALLRTHQTDSRYLVKQALDILAPVMSERMNDADSSDNWLKWPRRILSEDGFNDNWLKWPRRILSEDGFNVTQVLNVYQFIVQHPDLFFVAREHFVSNIITAMGKLTILANPAIENQVLAIELAELILYWERKAKDSKEESQATQEDENIEEDKEEAADTTTTAADKVKPEGDFTTSPNYSIPFGQREACVTFLIRYVCISPQRASESELGQKALGILYDLLSPEHWAEVSVKLTFFEKFLLAQDINSSNLLGYCLNALEVLGVVLEWKKPEWIVSNLSYLQKLLEKCIKSDNHDIQEVLQRVLSIILKAIADQKTPEEEDEEEDDVKEFLTLLTTTVTENLGDTSSVPAGVTLFWTLAHYRPSTLDNLLPTIMKTFSKLCKDHITMTHQGSQTSTSKDNANLEFEAKMTTKLLEKILKLCASRISNLGDQRRIFLSLLAQLIERSLDKDTLEKIIKIVKNWVFSRTDLFPTTKEKAAILSKMMVFEIRGEPSLSKEFYQIIVDIFEDDTFSCTELTVRMEQPFMVGTRSVDVSIRRKLMSILNNSLEKDIAKRLYYVIREQNWEYLADYPWLNQAMQLLFGAINFEQQIRLVDDENKLAPLKVLSFPESDKMDVDNNNSNSNKDELNELLKKHSGFIEAAGNIKVGDILEPLIDMFYQSGETIHRTWSSFFPIAFSSLPHSETLDFTRFMIILLSKDYHTRQVDMRPNVIQSLLEGVSRCDDLQLPPFAVECLASNFDAWSQGIHILENIDEKLVNANAEVREVTEDALAKLYATLKEDDMFYGLWRRRAKYAETISALSFEQLGLWDKAQQLYETAQIKARSGALPYGESEYALWEDHWILCSEKLQHWDILTDLARHEGFSDLLLECGWRVADWYNDRETLDQTVKNVMDVPTPRRQVFETFLCLQGFGQEKETLQDLSRLCDEGIQLALRKWHGLPERFANAHIPLLHTFQQYVEFMEASQVYASLVTTNAQNLDMKSQELKRVLQVWRERLPNVWDDINIWNDLVTWRQHAFQVINKVYMPFIPVLQQNSTGSNANSYAYRGFHEIAWVINRFAHVARKHNMPEVCIKELTRIYQLPNIEIQEAFLKLKEQVKCHYQNANELNTGLDVISNTNLVYFATQQKAEFFTLKGMFLNKLNQKDEANKAFATSVQIDLNLPKAWAEWGMFNDRRFKENPNDMVYANNAISCYLQAAGLYKNGKTRKLLARILWLISLDDASGTLAQAFENFRGEVPVWYWITFIPQLLTSLSQKEAKLAKQILVRIAKNYPQALHFQLRTAREEFAAQQRHVVDLARQQAAQVSAATATVPSSSSSPNGVNDTNSTNQQSKLNGSSAGNGDKTQQSPTSQPQQPPHPQINIPNSVRQPLEHIDEIMAILKTAYPLMALSLESLVDQINQRFKCTADEDAYRLCVALLNDGIQYLNKIGNPKEDAKLPPITEANITRFAETVLPKQIRAEFEKDLVISKPNLETYISKLRNWRDRLEDKLDRRFSQVNLENLCPHLSEFHHQKFEEIEVPGQYLLNKDSNAHFVKIERFLSTIDLARGSSACYKRLRIRGHDGSLHTFAVQFPAARNCRREESVFQLFRIFNDSISRKVETRRRNIQFTLPIAVPLSPHIRIVNDDTRDVTLQRVYEDFCKKNGKSRDEPFIYTVEKLRAAFDQRLPKPDIASVKVEILSAIQSLLVPSTVLKNHFINLYPNFEDFWLFRKQFTSQYASFIFTTYMMCINARQPQKIHVNRGSGAVWTSDMLPYRLSTRNNGEITHNKQSPIFVNTEQVPFRLTPNIQKLIGETGLEGVLSVYVLCIARALLEPESDLEQYLTLFVRDEVMSWYSQNDKAALSNEKQLSDIVRLNVENIIRRVMTMGHISSANGVANQHVLELISQAVNPRNLASADTLWMAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPW6</accession>
    <name>A0A1D8PPW6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">NIP7</name>
        <name evidence="10" type="ordered locus">CAALFM_C602360WA</name>
        <name evidence="9" type="ordered locus">orf19.10982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712517.2">
        <property type="nucleotide sequence ID" value="XM_707424.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPW6"/>
    <dbReference type="SMR" id="A0A1D8PPW6"/>
    <dbReference type="FunCoup" id="A0A1D8PPW6">
        <property type="interactions" value="1154"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPW6"/>
    <dbReference type="GeneID" id="3645880"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602360WA"/>
    <dbReference type="CGD" id="CAL0000185986">
        <property type="gene designation" value="NIP7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02360W_A"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPW6"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000185986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="181" mass="20611" checksum="19CFE645ECD37552" modified="2017-01-18" version="1">MRPLTEEETKVVFEKLANYIGRNISFLIDNPENPHVFRLQKDRVYYVQESIAKFATSVSRQQLMSLGTCFGKFTKTGKFRLHITSLPYLAQYAKFKIWIKQNGEMPFLYGNHVLKAHIGRMSDDIPEHAGVIIYSMNDIPLGFGASAKSTAEARNLPPTGIVAFRQGDIGEYLREEDTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ77</accession>
    <name>A0A1D8PQ77_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C603600CA</name>
        <name evidence="11" type="ordered locus">orf19.13150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="526" mass="59739" checksum="D91BEF558313F2D2" modified="2017-01-18" version="1">MSSTTFNDIIDSVLPYLTKWYTILIGAGLIFVLSTNLKNAYYSYKLGCKNPVHLKRAGWTGIPALIDAIKAKNSGKLAEFGGDTFDELNSKNFYLNVAGVLKIIFTIEPENIKAVLATQFNDFSLGTRHAHFYPLLGDGIFTLDGEGWKHSRAMLRPQFAREQIAHVKSLEPHIQILAKQIKLNKGETFDLQELFFRFTVDTATEFLFGESVHSLYDDKLGIPPPNDIPGRDNFATAFITSQHYLATRSYSQTFYWLTNNKEFRDCNAKVHHLAKYFVDKALNSTEEEIEEKSQGGYVFLYELVKQTKNPKVLQDQLLNIMVAGRDTTAGLLSFAMFELARNPKVWNKLREEIEANFGVGEEARVEDITFENLKKCEYLKAILNETLRLYPSVPINFRTSTKDTTLPTGGGPNGTSPIFVPKGSTVAYTVFKTHRLEEYYGKDSHDFRPDRWFEPSTKKLGWAYLPFNGGPRICLGQQFALTEASYVISRLAQLFPVLESRDEQYPPNKCIHLTMNHDEGVFVSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQL0</accession>
    <name>A0A1D8PQL0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fgr2p</fullName>
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    </protein>
    <gene>
        <name evidence="9 10" type="primary">FGR2</name>
        <name evidence="10" type="ordered locus">CAALFM_C700480WA</name>
        <name evidence="9" type="ordered locus">orf19.7071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQL0"/>
    <dbReference type="SMR" id="A0A1D8PQL0"/>
    <dbReference type="STRING" id="237561.A0A1D8PQL0"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PQL0"/>
    <dbReference type="GeneID" id="3637988"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700480WA"/>
    <dbReference type="CGD" id="CAL0000194373">
        <property type="gene designation" value="FGR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00480W_A"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQL0"/>
    <dbReference type="OMA" id="SGWRYLM"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
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        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000194373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="514" mass="57325" checksum="AA6C8E81013F6E63" modified="2017-01-18" version="1">MSDIEKKQTKISPASSVAHDEDTLANDELFQLTDSVLNKKLKLINDAIDEIGFTPYHLKLFFLNGMGYWTDTQLTYLESSVRTFVNYQFGYKYPVSNEMLAAGLLVGALFWGFSADLIGRRLAFNLTLLLSALFTILTGVMNNMASYCIFVFLSCFAAGGNLVLDTCIFLEFLPHKDQWLLTFFAFFWGIGQTIAVALAYAFLPNNSCESADNCPSHINRGWRYVYYTNGSIVLAMAILRLTLIRLQETPKFLVSNNRDQEAVEILQRIAQKHNRTCSLTIEDLESLGKVEINDDYRKHIDIKGTFRLVTHHVQILFSNRTMARSSVLVFVSWLLLGISYPLYSSFLPVYLATRGANISAPDVHGVYRDNLISNCVSMGGPLIAGALLFCFPWLGRRGVLFIGGVASMAFLFGYTQIKTRAQNVALSSISFASMYIYYSALYAYTPEVFPSVARATGNAIAIACTRVMTCIVPVIAYYSNTSSSVPIWVCGAFVGVIGFLALLFPYEPSKQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR83</accession>
    <name>A0A1D8PR83_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">CYR1</name>
        <name evidence="18" type="ordered locus">CAALFM_C703070CA</name>
        <name evidence="17" type="ordered locus">orf19.12615</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716974.2">
        <property type="nucleotide sequence ID" value="XM_711881.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR83"/>
    <dbReference type="SMR" id="A0A1D8PR83"/>
    <dbReference type="FunCoup" id="A0A1D8PR83">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PR83"/>
    <dbReference type="GeneID" id="3641407"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703070CA"/>
    <dbReference type="CGD" id="CAL0000178292">
        <property type="gene designation" value="CYR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03070C_A"/>
    <dbReference type="eggNOG" id="KOG0618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PR83"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036164">
        <property type="term" value="P:cell-abiotic substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036171">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900430">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900439">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900743">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070786">
        <property type="term" value="P:positive regulation of growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900241">
        <property type="term" value="P:positive regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900239">
        <property type="term" value="P:regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900231">
        <property type="term" value="P:regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:symbiont-mediated evasion of host immune response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001515">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048580">
        <property type="entry name" value="CYAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21187">
        <property type="entry name" value="CYAA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="304"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="1005"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1329"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000178292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW30653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1690" mass="189399" checksum="24CD4CC93B5F79ED" modified="2017-01-18" version="1">MSFLRRDKSKANFRDGSATGLEEPVSPTTHFSPNAPPPLDGNHGDHYHDPDSPRSSVVSLPQLIHNSATHHLKENYRGFHANKRPKGIANVPPLAQPIKPRFKKKSNSLLNKLIYSTKKEDDETATSGKESRSSSIISDEKRKSASSASSGSSRQKFRFSSFDSNLSTSSSSPPKDKKASISDTVSDSSTVTASMSNMPTISIDLNLDEMHDIIKSPETPAPTVGLPTQKAEKKASPTAIKNWQAPESWDVKAPIKKEEPHAPKIEEVAENDVAIDNVLEKKRLPVLYGTHQVPHVTNSKDIKSSHIIRVFKEDNTFTTILCPLETTTSELLAIVQKKFFLESTTNFQLSVCIGNCVKVLEDFEKPLKIQMGLLLLSGYTEEDKLRMLGREDLSFVCKFVVENIFLRSLTHDEEVLLSRNYVDVNISSLNLKNVPIIFHQHTYEIEKLNVANNPSIYLPLDFIQGCTSLAYVDFSHNGCSKFPNNLLEAPQLTHLNLEMNFLDEIPQRISCLSNLTNLKLSSNQLYSLPHSFSTLTNLKQLDLSSNYFDSYPEAVNKLTNLVELNFSYNDLSIIPESIANLINLQKLNLCTNKLSGTLPGYLSQLKALKRLDIRYNYISNVDVLGIIPNLEVAYASKNAISTFSDQMKCLRLLHFDRNPITELKFNTQMQMLSVLDLSRAKITAFPAEFVEKVPNIEKLVLDKNHLVSLPNELCQLSKLVSLSVHANNLQSLPANIGDLRFLKYLDLHSNNLKSLPDQIWDLCHLTSLNVASNNLTSFPKAPYSVVKRLSSSLVDVHLESSQTLSLADSLLILILSDNRLSDDCFDEISFLIALKSLNVSYNDLIEIPQGTLSRLTRLNELYLSGNELTTLPADDLEVLKSLKLLYMNNNKLVSLPAELSRIANLQHLDVSSNQLKYNISNWPYDWSWHWNKNLKYLNFSGNKRFEIKQSHIKNPETGEDFDSLLVLKQLRVLGLIDVTLTTTNVPEQAVDLRLRTTASEFDNFGYGVSDSLGMRDHVSARDLFVQKFRGKENEMLLCAFDGKHGATNQGHRISLVAKNMFVRNFTKELDEIKNDDEIENALRKAFLNFNKEINGILTAKKNKSFTPVPNMSKEALELNLVDDGNAGCTVSVIYIKDKKLYSANIGDIEALLCRNNGDQFLLTEKHDPTNREEFERIRASGGYVSGGGELDGQLSVSRGVGFFNFLPHTHCGPTIRRFKITNDDDMIILGSKQLWDFISYESAVDIIRKDKNDPMVAAQKLRDFAICYGATDKICVIVLTFGNRQKQAANMYSNYGVDRRRRDKQQVVGGDSNLRKLEQEIEPPIGPLALVFTDIKNSTLLWDSYPAPMRSAIKIHNTIMRRQLRITGGYEVKTEGDAFMVAFPSPTAALLWCFQVQQNLVTADWPSEILETDQCCVVSDSENNTIFRGLSVRMGIHWGSPVCEPDVITGRMDYFGPMVNRASRISAIADGGQIAVSSDFLDVLNSLTVKHNNIKNNVESLIDAYQGNENAGMTIERELNALEDLGCNYFKIGERKLKGLETPEPITLVFTNRLKLRYDIFQKRLDANHSTRVAGTLPVEIIYGLRTVSLRLENLCSSINNGGNYCSEGFESSSGVISQKMNSSFKDSDLISLLNHVTTRIESCTTTLFLRQQLSQIKGNGGLIETNNSPSLDVIMDEIADIMKTVNELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRH8</accession>
    <name>A0A1D8PRH8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">MED9</name>
        <name evidence="9" type="ordered locus">CAALFM_C704100CA</name>
        <name evidence="8" type="ordered locus">orf19.7165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715214.1">
        <property type="nucleotide sequence ID" value="XM_710121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRH8"/>
    <dbReference type="SMR" id="A0A1D8PRH8"/>
    <dbReference type="STRING" id="237561.A0A1D8PRH8"/>
    <dbReference type="GeneID" id="3643134"/>
    <dbReference type="KEGG" id="cal:CAALFM_C704100CA"/>
    <dbReference type="CGD" id="CAL0000183091">
        <property type="gene designation" value="MED9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_04100C_A"/>
    <dbReference type="eggNOG" id="ENOG502SFWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRH8"/>
    <dbReference type="OMA" id="DFHNNAG"/>
    <dbReference type="OrthoDB" id="4092914at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000183091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="218" mass="24774" checksum="A5FEA3EF91FBB288" modified="2017-01-18" version="1">MYSNRKISRPKFILIVQLIMSSPQPNDSNSKMPSPMLSNDTSMLGDINIGTPIDLTIDNSVIQQTQQENLSTNDNMEVDDVVTSEIAQNSNELEPAKIEVKSEPPEQFTQEQAQLETEPDVDPIEKMRSLEILPDLFNLLYDLNNEENSKVTPKDFDKYLGSLRLKLSNLKNLMSEVEGINETLSYTLDKIESLKQNNIKKEAFLSNFKNSVNMNEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRM4</accession>
    <name>A0A1D8PRM4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_CR00230WA</name>
        <name evidence="6" type="ordered locus">orf19.7511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718668.1">
        <property type="nucleotide sequence ID" value="XM_713575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRM4"/>
    <dbReference type="SMR" id="A0A1D8PRM4"/>
    <dbReference type="FunCoup" id="A0A1D8PRM4">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRM4"/>
    <dbReference type="DNASU" id="3639698"/>
    <dbReference type="GeneID" id="3639698"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00230WA"/>
    <dbReference type="CGD" id="CAL0000198338">
        <property type="gene designation" value="orf19.7511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00230W_A"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRM4"/>
    <dbReference type="OMA" id="AYGFIEW"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000198338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW30794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1847" mass="209942" checksum="57F3BA010AB56D2B" modified="2017-01-18" version="1">MSGIFNWSSDVFADIYNTLKFESNIDLDTIDFTSIKNDLANVLITPVPSDQSRSKLGDASKPVALPSGDEVKLNQASIEITGVLSNELDLDELNTAELLYNASDLSYKKGTSIGDSARLAYYLRAHYILNIVGYLVSHKRLDIITNNNQVLFDNILKSFSKIYTLSGKLNDMIDKQKVTGDINNLAFINCINYSRSQLFNAHELLGQVVFGLADNYYESYGTLNNYKSLVEFISKNISDEDVFVIHFLPSTLQLFKKLLQLGEESLVDQFYKTITSSILKDYEANNFSKSEDIDLSKSKLSGFEIVTSFIFLTEFIPWCKQSSSRTAKYDFKDDILKYMEFLISYGVMERLLSYCSETANAKTQQVYDWSNMYDFRALLQKNFPRLTPAKFHYPGNQELLNAVRPGYENVSKLIDISFLTLDPSLNETLVSPFFQSFFSVFISNAAVVMTSLRDSEEDFVLSSLNESDEEEEEEESDSDEDSSTPKNKEKSTGLDLDKIAQRAELERFYLAFAYTYNNRPELCALFWGNEQVTHDIIGFISWGLANNTSPLITATFCLLLGSLASAGAEATSRIWEILVHNNNNASTRKNDFSKISVDSLYDSLKYYIDSLNESFEQDLNAQLMLNQKKQDFLFSTTTSKQDLDDSGENRIVIELAEDSLVFISGFIQLLSAIVKNLNTKNERSKEIKSVVYTRFSPIIKGFLKFDNLINGSRFLQVDASIQSTNNPKFIDLPNVFVSDDSRIILTNLILTFLGDFVTNDSDPYIRYEIWRLVDRWMYQGLHSLPEDKKDDAFRHIKRKYISKKNVPINQAFSTNLTHLSQIGNFTVLVKKLLTPYADSNEAFTKYSLLYPCDLGSGYRFNNQLGIWPYIEFLMQNVFANSATIANKRDRVNLQLNLLELFSNALQEVDWKFLIDVAPKIIRDLKNFNGIFDSLIPGVQLDFEVFVKLHHSVAVINYLFENKTFSALFKLVNIGVDSVNESGESAALVSHALGLINSLLRVQNSFINKLLPILRNKDTQQQLHCGTAIGIGTSMSLSLATPRTIFDCIYYPKNLGTHGVADFYEVILFHLSAVVQFALYVSCENTISNKAISILKGVSQSKFFVTRVSSSADPLLNNDRLITTFENIDESIKIKFAFIDKFEELEDSLNMKYEILDFVLGNLNQFDGKVATTAHFLLGYKVKGDTLDLVQTNDQNTLLKSFLNTLSISLDLISEIDYNNGNNHIIDVGPAKLSSLILQILIKLCQDPISSSITLNQLREYEELFEKLVNCQPKLDLNTVWCGNQFDGDLQIDASNVFVDNQASTQAFFSFINQRNLILQYLSLEFHSVKSRTKREYYSKVLTNDKEFVNRTPKVLTFLNILNYSFKNFEVQKYEWLDQKFNMSLLLAEVNAQKNGTLDFSVLTKVFRLLCQTSNLITPESKQLFAEEIMVEGSKISDFVTKYSVSTDLKDVQLKCLHSWCQLIEILVTDSGINSSNFILEVLQVIIPKINDYFDVDISFSEEMVSLCVLLFDLYDQSTLADRKGEDFALGIERLIPLFQTCIAGILNSNSTPSLRSDLYVVGNKFLLKCFERESFLKQVMHIIKSVDKKFFQVICNDAIYSEGPSRITSTLFLESLVHLGTLVKVDFILNALIKNNALSLLVRSVKRTDAMIKLCQEKNSGVTLDHFIFDLMAFKATLYFFVRVAKSKNGALQLIQNELFSILHQSKFLQIDPDIGLSLRIEEVQDHKTVNVNVLLDTPLSITDLVDPYKLRSENTISYFEFLVPIFQLLTTVLLSMGPNYQPAIIQTRELMKSVNRLVVGVMKRDFLVETKQIGQGLYKEESHELVSLKELVKLFILIDSLAHYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRM9</accession>
    <name>A0A1D8PRM9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR00280CA</name>
        <name evidence="2" type="ordered locus">orf19.7506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718663.1">
        <property type="nucleotide sequence ID" value="XM_713570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRM9"/>
    <dbReference type="SMR" id="A0A1D8PRM9"/>
    <dbReference type="STRING" id="237561.A0A1D8PRM9"/>
    <dbReference type="GeneID" id="3639719"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00280CA"/>
    <dbReference type="CGD" id="CAL0000188531">
        <property type="gene designation" value="orf19.7506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00280C_A"/>
    <dbReference type="eggNOG" id="ENOG502S4MM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRM9"/>
    <dbReference type="OMA" id="QHDNQND"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000188531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="407" mass="47971" checksum="C5E5780D55B74875" modified="2017-01-18" version="1">MVSRSHSSTPVPIDASHPIHSLNIGNQDQIASLSKQTPIILLNQQEENGFQTPELVALRNSNKYVFVINWLYNYRGYLKLQSELFDVDLFELELLGFFSAFDLSSLFINKLKLALITSVQNSKHVELEDFEFVFRSHFGSDSPLGVQTDNEQDSVKFDLLNITEKFDILYILINYISKYSKFRDWTEKQGLATRLDPLFKLSSTEYFSLFDDNRLYKRTITYYPLTIPKKRKLSPESPQDYFEEKVFDVKDVKFELIYKNIYEFNEYLTKIKKSSAHKLLYTKLAGKSSAIIDTIFNNEIKKRKYLINKRKEIQMVNLLAVRKRSSRLEAKKQRQEELDRQREEESKYAAERRFERRMKLKNTENIDTGKLSRDQRMKLRQLNNESTPETETNPTPEPEQPEVIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRT5</accession>
    <name>A0A1D8PRT5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">GSL2</name>
        <name evidence="14" type="ordered locus">CAALFM_CR00850CA</name>
        <name evidence="13" type="ordered locus">orf19.10779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717960.2">
        <property type="nucleotide sequence ID" value="XM_712867.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRT5"/>
    <dbReference type="STRING" id="237561.A0A1D8PRT5"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PRT5"/>
    <dbReference type="GeneID" id="3640410"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00850CA"/>
    <dbReference type="CGD" id="CAL0000186782">
        <property type="gene designation" value="GSL2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00850C_A"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRT5"/>
    <dbReference type="OMA" id="IKHCEYM"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF97">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1253"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1340"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1381"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1419"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1485"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1522"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1575"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="12">
        <location>
            <begin position="90"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000186782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW30850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1640" mass="189424" checksum="807AAC1511870FB0" modified="2017-01-18" version="1">MFDYLMRLLDSRTSRLGPTHALRSIHADYIGGMNSNFRKWYFAAQLDIDDFVGFDNLAKNGKIKGSNDPVPTLEQAESQWSTNMLALSPTDSVIQLAIYLLIWGEANNIRFMPECICFIFKCCNDFYFSIDPDTPVTTVTPSFLDHIITPLYNFYRDQSYILVDGKYRRRDKDHESVIGYDDMNQLFWYSKGLERLVLADKKSRLMSLPPGERYEELNQVLWNRVFYKTFKENRGWSHVLVNFHRVWIIHSAVFWYYTAFNSPTLYTKNYQPALDNQPTTQARLSVLAFGGVVAIVIDIISLLFELRFIPRKWTGAQPVSKRLALLILALILNVGPSVYLFMFIPLNVQNTVGLVISAFQFSFSVIMVLYLSTVPLGRLFSKKPKANDRRFLPQRSFVTNFYSLAEGDRVASYGLWFAIFVSKFIESYFFLTLSLRDPVRELSIMKMSRCAGEVWLGNWFCTRQPTIVLGLIYLTDLVLFILDTYLWYIVWNTVFSVCRSFYIGVSIWTPWRNIFSRLPKRIFSKIISVSGDKNIKSKLLVSQVWNSIIISMYREHLISLEHVQKLIYKQIDNPGVEGDSVLKEPIFFVSQEDQTIKSSLFQDQAEAQRRITFFAQSLSTPMPEVGPVHLMPSFTVLIPHYSEKITLSLREIIREEEQYSHVTMLEYLKSLHPLEWSCFVKDTKLLAEEFETDSSSAEIKREKLDDLPYYSVGFKVATPEYILRTRIWASLRSQTLYRTISGFMNYSRAIKLLFDVENPDSTKFGTENDKLEQAAIMAHRKFRIITSMQRLKYFTPEEKENTEFLLRAYPELQICYLDEEVDEASGEIVYYSALVDGSCAILENGEREPKYRIRLSGNPILGDGKSDNQNHSLIFCRGEYIQLVDANQDNYLEECLKIRSILAEFEEATFPLDPYSTDLEGTESVYPVAIIGTREYIFSENIGILGDVAAGKEQTFGTLFARTLAHIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIYAGMNVVLRGGRIKHCEYMQCGKGRDLGFGSILNFTTKIGAGMGEQMLSREYFYMGTQLPLDRFLSFYYAHSGFHLNNLFIMLSIHLFLLVGANLAALTSESTICEYDRFRPITDPKRPHGCYNLIPVVHWLQRCIFSIFIVFVISFVPLAVQELTERGFYKAITRLGKQFASFSPLFEVFVCKIYAHSLSSDISIGGARYLATGRGFATIRVPFATLYSRFAVESLYYGSICGLLIFYCSLSMWKLQLLYFWITILGLLICPFLYNPNQFSWNDFFLDYKECIQWFYRGNSKPRLSSWINFTRLKRSRIVGVKSKRYSINEEIKVVSEVKPSRFKLIISESFLQLCVITLVGLAYLFTNSQNESRGTYPVNSILRILIISFVPIGVNLVILIACFVVSISIGPIFTLFCKKFPSFVAAIAHLLAVANHVFFFELLWLFQNWNFSVTVLGFALSALIQCWFLQMMTILLVSREFRHDRSNRSWWSGKWATAGLGWYIITQPMREAVCKLSEMSYFAGDLVATHIILFAQIPILLIPYADKWHTLMLFWLKPGNQIRPRILSKRQKRRRRFQANLYLLIFLLGLILFSSIFVLPLIATKYFDIEFSEYIPEFFHPLFQPYDAPTNSKGLKKKLEIKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS08</accession>
    <name>A0A1D8PS08_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_CR01630CA</name>
        <name evidence="12" type="ordered locus">orf19.10084</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718220.2">
        <property type="nucleotide sequence ID" value="XM_713127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS08"/>
    <dbReference type="SMR" id="A0A1D8PS08"/>
    <dbReference type="GeneID" id="3640085"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01630CA"/>
    <dbReference type="CGD" id="CAL0000194965">
        <property type="gene designation" value="orf19.10084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01630C_A"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS08"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000114">
        <property type="entry name" value="H /K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111365" description="Cation-transporting P-type ATPase C-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="11">
        <location>
            <begin position="445"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000194965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW30922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="654" mass="73147" checksum="D5736998C7F4823A" modified="2017-01-18" version="1">MKQHQILVKSLHMCGTLASCSVLCFDKTGTLTQNNMKVTLSCIGDKLHEESEKEENNDIFDSCAATQVFTIGALCNEATIVNNTALGGNATDRAILQFVEKNTSTEILKAKWMKKLDIPFNSKDKYMISLVEPVKATATSSWNEIGFEDNENFLLLVKSAPDVLIDNCQFRMNENGTLQPLTTDEIQYYKDIQRKWSSDGKRVILFASKMVSRQSLNLADRITSANKLKEEIGSGLIFMGLVGIEDPPRKNIDHVIGILRDAGIKIVMITGDFELTGVSIAKQCGIVTSGKIAKVNTLGDSDKNSISVTGPELNSLDESQWEQLVAHNELVFTRTTPEQKLLIVEKFQKYGQVVGMTGDGINDAPALKQSDIGISILDASDIAKEAADLILMNSDADQLFLSIVEALKFGRLVFENLKKTICYLLPAGSYSELWPVVMNVFFGMPQMLSSFLMIIICCLTDCAGSIVLAYEGAESNLLKKKPRVVTGERLVNFKLLFHAYFCLGTFYTFTSFLVAFLNLTRRGLKFDQFSLSFGSYQDIPNVTNWLNMSSSIYFVNLIILQMFNLLSLRTRHLSLFQHSILKNKKVIFVVPFVLLVNFVINYIPAIQRTMGTSQVPVEYYFIAVGFGLVVFTYDELRKLIARKYPNSFTARIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSP7</accession>
    <name>A0A1D8PSP7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">SNP3</name>
        <name evidence="12" type="ordered locus">CAALFM_CR04260WA</name>
        <name evidence="11" type="ordered locus">orf19.8145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331079.1">
        <property type="nucleotide sequence ID" value="XM_019475534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSP7"/>
    <dbReference type="SMR" id="A0A1D8PSP7"/>
    <dbReference type="FunCoup" id="A0A1D8PSP7">
        <property type="interactions" value="1110"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSP7"/>
    <dbReference type="GeneID" id="3640991"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04260WA"/>
    <dbReference type="CGD" id="CAL0000178800">
        <property type="gene designation" value="SNP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04260W_A"/>
    <dbReference type="eggNOG" id="KOG3448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSP7"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000178800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="96" mass="10992" checksum="2FBB69BCBB3B7327" modified="2017-01-18" version="1">MLFFSFFKTLVDQEVTVELKNDIEIKGTLKSVDQFLNLKLDNITCTNGQRYPYLGAVKNLFIRGSNVRYVHMNPNSVDCTLLQDASRREAMVQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSW2</accession>
    <name>A0A1D8PSW2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">low-specificity L-threonine aldolase</fullName>
            <ecNumber evidence="8">4.1.2.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_CR04880WA</name>
        <name evidence="12" type="ordered locus">orf19.13682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-allo-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:26209"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58585"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:19625"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid degradation; L-threonine degradation via aldolase pathway; acetaldehyde and glycine from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.48" evidence="8"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711090.2">
        <property type="nucleotide sequence ID" value="XM_705998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSW2"/>
    <dbReference type="SMR" id="A0A1D8PSW2"/>
    <dbReference type="FunCoup" id="A0A1D8PSW2">
        <property type="interactions" value="1039"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSW2"/>
    <dbReference type="GeneID" id="3647309"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04880WA"/>
    <dbReference type="CGD" id="CAL0000176940">
        <property type="gene designation" value="orf19.13682"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04880W_A"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSW2"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050410"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050939"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000176940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="369" mass="41324" checksum="7A3B49DE87F9B8F2" modified="2017-01-18" version="1">MDFSTFDKQSPAHNDFRSDTFTTPTTSMIQSLAQTTLGDAVYNEDLKTIELEQKVAELTGKEAGLYCVSGTLSNQIAIRTNLYQPPFSVLCDYRAHVYVHEAGGLSTLSQAMAQPINPKNGIHLTLEDDILPNFIIDDGEIHGAPTKLICLENTLHGMIFPIEEIKKISKFCQQNNVKLHLDGARIWNASAETGISLKEYCSYFDSVSLCLSKTLGAPIGTVLVSDKKFILKANHFKKQNGGGIRQSGLLASMAIIAIDENFSKLKQTHIWAKELGKLCDENGIILEHPVQTNFVFIDIAANKINPEKLMEISDKYNVKIYSGRIAFHYQISQESFENAKKVVLEVIQYAKDHPYEEKTNFKFYTSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT01</accession>
    <name>A0A1D8PT01_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_CR05450CA</name>
        <name evidence="4" type="ordered locus">orf19.3516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
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    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710161.1">
        <property type="nucleotide sequence ID" value="XM_705069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT01"/>
    <dbReference type="STRING" id="237561.A0A1D8PT01"/>
    <dbReference type="GeneID" id="3648236"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05450CA"/>
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    </dbReference>
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    <dbReference type="OMA" id="DVFTWQM"/>
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        <property type="component" value="Chromosome R"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000192248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="215" mass="24230" checksum="06A25842A95C0F8F" modified="2017-01-18" version="1">MSTEVNQTVSKVKGAIEDESITEQESGFRYAAYANRLRTILLASHRYVAYTSDIGESFRPVAHPYLVKSGYAVSWLYILGDVSYASWITKMKAEGRYEPGLKPWDKAPAPNEIAAKTFTSTHSLVDSDWRWSALKRGIFQSIASMGLPAFTIHSSVRYSSYLFKNSKVPVLKTYGPVAIGLGIVPVLPYIFDEPVEHAVDWVFEQGEDIYRQKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTB6</accession>
    <name>A0A1D8PTB6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR06850CA</name>
        <name evidence="10" type="ordered locus">orf19.1848.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331096.1">
        <property type="nucleotide sequence ID" value="XM_019475551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTB6"/>
    <dbReference type="SMR" id="A0A1D8PTB6"/>
    <dbReference type="FunCoup" id="A0A1D8PTB6">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTB6"/>
    <dbReference type="GeneID" id="30515424"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06850CA"/>
    <dbReference type="CGD" id="CAL0000187569">
        <property type="gene designation" value="orf19.1848.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06850C_A"/>
    <dbReference type="eggNOG" id="KOG3808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTB6"/>
    <dbReference type="OMA" id="KVGFQGT"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009026868" description="Protein kish" evidence="9">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Federspiel N.A."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="181" mass="20316" checksum="7744EF380EE1094D" modified="2017-01-18" version="1">MFAFKKSTTSILKTVVAPTSSRYLSTVTLRSIPRTFHNATKVSLFNGLRTTPRFYSVLTESPEAKVYKYADVKDVAVHPENHPDSVLVDVREPTEFGDGHIPGALNIPFKSSPGALDLPEEDFQEHFGFPKPSTDKELIFYCLGGVRSTAAEELANTFGYKKRGNYLGSWEDWVKHENKKN</sequence>
</entry>
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    <reference evidence="7 8" key="2">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
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        </reaction>
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        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU73</accession>
    <name>A0A1D8PU73_CANAL</name>
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        <recommendedName>
            <fullName evidence="11">Trs120p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_CR10290CA</name>
        <name evidence="8" type="ordered locus">orf19.7604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
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        <property type="entry name" value="Trs120_TRAPPC9"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="5"/>
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    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="5">
        <location>
            <begin position="743"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="6">
        <location>
            <begin position="987"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26251"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF26254"/>
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        <source>
            <dbReference type="Pfam" id="PF26283"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000190214"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1274" mass="143162" checksum="C8885A29AB0B9D2F" modified="2017-01-18" version="1">MWDKYNFITPAKVRVLLVPINDCTPSNFQRYLHLIQTNVGEVRLLDIRENNKLHYFNSVTSPQGRIFPEFITSSIDNELIFLHDFDPFRKTFIVLGVGPYGQDPSTALVELKKKYNTAIVHNVILFDTPEDKLNEQVPEVFFHNGTTSHLTALETIFCDISGNFLEKLDAYASAYANITLRSPVSITDSHVLTKTINQAQKRLSSGSTSFKVTFNNSTTTSTTTPGSTLEKSKTHLKHLGRQRKLMGSFYLLAGKYHDAFQNFIESLTSLKKSDDFLWLASALEGVAVSIVLMQFIGTAYQLPNQTMNPVLQVSKIRGSIDTATVRKTSIDSNVSSPRNSINGSNGFGFNALTSAIPDFNNLPVQELLKIITSRVVYYFSMSTNDIENMVPDIVYVESILRRIKLLIGIHFSSSMEDIVKGTITPTPNGSFPKIEIIDEIDKIFSLQITDLNIVDQCRIYSALATMYADLGLMRKNAFILRLLISAILPHLSSGELPAQSIKEVLENVFVLYDICDEPESFSEAARFHGQSNWTSLQIQLLRLALKVAENLNDQELLLKLCTLLLTRYTHCLPTDDQIKLKNKVDSALKSNGGLSIPYWDPFLVRKVKFVNSKPRGNLIPMKETLNSNNSSQPFFDPYTKKESDKAFVPTLVKDDISQLKVTLQNPFAFEVEIHEITIVSEGAQIETIKSLIRPLESITSKPSSTMPNGNIVNNKLRGHPGKKSSSTTSVVHQGVSHTTSTNSASTFVLAPRSMESVMLSFKAISTGQVKITGFDVSIGNCQTQFFHIIDEEKFDHTIKLQKVNQKSKQTTSVLDKVVTNLQSQSVLGRVMTSSLSLSIIPPQPSLTLLEISASNGCLMLLEGEKHNVTVTLANHSAQSINYLTFSFWDSNIEFLNKKLTNPNLTAAEVHELEWKLLVFKPFRILNKDVIGETINPGGVVELQCELTSRKFMNESKIILEYAHKSDTEQSFMKNLNIPLNVSVMPSIDVVGCEMLPAISISDNVPHSIGQALKCVKNVDDYCLLVLDLRNSWGERLECNLKYNEFELSEPMQAGKTQRFIIPIKRIEVDITKTIPSLRNKQFIKNYNISDEEEKHMKKLFWLRNSILENLVGSWKLGRRHGVIDLRPIRLTTKMANILSYENIQVHNTVLTDDDLQVDSIGKSYNLSTDQFYVLKTTIINHSKKPINGIVRQLPFPIHNTPTKSSSSRPQLSIDKKMLVNGTLQNKFPEIAPGDQLVLETSFVIIQNGEFEWGTVVDLFSDKIICREQLYITAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G1UB61</accession>
    <accession>A0A1D8PMT9</accession>
    <name>CDC11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Septin CDC11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cell division control protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CDC11</name>
        <name type="ordered locus">CAALFM_C500070WA</name>
        <name type="ORF">CaO19.5691</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="41" first="19" last="31">
            <title>The germ tubes of Candida albicans hyphae and pseudohyphae show different patterns of septin ring localization.</title>
            <authorList>
                <person name="Sudbery P.E."/>
            </authorList>
            <dbReference type="PubMed" id="11454197"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02459.x"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="Mol. Biol. Cell" volume="13" first="2732" last="2746">
            <title>Septin function in Candida albicans morphogenesis.</title>
            <authorList>
                <person name="Warenda A.J."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="12181342"/>
            <dbReference type="DOI" id="10.1091/mbc.E02-01-0013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Infect. Immun." volume="71" first="4045" last="4051">
            <title>Candida albicans septin mutants are defective for invasive growth and virulence.</title>
            <authorList>
                <person name="Warenda A.J."/>
                <person name="Kauffman S."/>
                <person name="Sherrill T.P."/>
                <person name="Becker J.M."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="12819094"/>
            <dbReference type="DOI" id="10.1128/IAI.71.7.4045-4051.2003"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="55" first="381" last="395">
            <title>Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence.</title>
            <authorList>
                <person name="Umeyama T."/>
                <person name="Kaneko A."/>
                <person name="Nagai Y."/>
                <person name="Hanaoka N."/>
                <person name="Tanabe K."/>
                <person name="Takano Y."/>
                <person name="Niimi M."/>
                <person name="Uehara Y."/>
            </authorList>
            <dbReference type="PubMed" id="15659158"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04405.x"/>
        </citation>
        <scope>INTERACTION WITH HSL1</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="Yeast" volume="21" first="1025" last="1033">
            <title>Tandem affinity purification of the Candida albicans septin protein complex.</title>
            <authorList>
                <person name="Kaneko A."/>
                <person name="Umeyama T."/>
                <person name="Hanaoka N."/>
                <person name="Monk B.C."/>
                <person name="Uehara Y."/>
                <person name="Niimi M."/>
            </authorList>
            <dbReference type="PubMed" id="15449307"/>
            <dbReference type="DOI" id="10.1002/yea.1147"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>IDENTIFICATION IN THE SEPTIN COMPLEX</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Eukaryot. Cell" volume="4" first="1191" last="1202">
            <title>Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth.</title>
            <authorList>
                <person name="Martin S.W."/>
                <person name="Douglas L.M."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="16002645"/>
            <dbReference type="DOI" id="10.1128/EC.4.7.1191-1202.2005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2007" name="J. Cell Sci." volume="120" first="1898" last="1907">
            <title>Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation.</title>
            <authorList>
                <person name="Li C.R."/>
                <person name="Lee R.T."/>
                <person name="Wang Y.M."/>
                <person name="Zheng X.D."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="17504812"/>
            <dbReference type="DOI" id="10.1242/jcs.002931"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2007" name="Dev. Cell" volume="13" first="421" last="432">
            <title>Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.</title>
            <authorList>
                <person name="Sinha I."/>
                <person name="Wang Y.M."/>
                <person name="Philp R."/>
                <person name="Li C.R."/>
                <person name="Yap W.H."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="17765684"/>
            <dbReference type="DOI" id="10.1016/j.devcel.2007.06.011"/>
        </citation>
        <scope>PHOSPHORYLATION AT SER-4; SER-394 AND SER-395</scope>
        <scope>MUTAGENESIS OF SER-394 AND SER-395</scope>
        <scope>ACETYLATION AT MET-1</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2010" name="Eukaryot. Cell" volume="9" first="224" last="226">
            <title>A photostable green fluorescent protein variant for analysis of protein localization in Candida albicans.</title>
            <authorList>
                <person name="Zhang C."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="19915075"/>
            <dbReference type="DOI" id="10.1128/EC.00327-09"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2012" name="Antimicrob. Agents Chemother." volume="56" first="4614" last="4624">
            <title>Rapid redistribution of phosphatidylinositol-(4,5)-bisphosphate and septins during the Candida albicans response to caspofungin.</title>
            <authorList>
                <person name="Badrane H."/>
                <person name="Nguyen M.H."/>
                <person name="Blankenship J.R."/>
                <person name="Cheng S."/>
                <person name="Hao B."/>
                <person name="Mitchell A.P."/>
                <person name="Clancy C.J."/>
            </authorList>
            <dbReference type="PubMed" id="22687514"/>
            <dbReference type="DOI" id="10.1128/AAC.00112-12"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 9 10 11">Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinase GIN4. Septins are also involved in cell morphogenesis, chlamydospores morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization, and spore wall formation. CDC11 is required for the correct localization of SEC3 at bud tips and bud necks. Plays a key role in invasive growth and virulence.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SEP7. The purified septin complex appeared to have a stoichiometry of 2 CDC3, 1 to 2 CDC10, 1 CDC11, 2 CDC12, and 1 or none SEP7 subunit. Interacts with HSL1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5 12 13">Bud neck</location>
        </subcellularLocation>
        <text>Localizes to a tight ring at the bud and pseudohyphae necks and as a more diffuse array in emerging germ tubes of hyphae.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Hyphal induction causes immediate phosphorylation at Ser-395 by GIN4 and at Ser-394 by CDC28-CCN1. GIN4 phosphorylation at Ser-395 primes CDC11 for further phosphorylation by CDC28-CCN1. CDC28-HGC1 then maintains CDC11 phosphorylation throughout hyphal growth. Ser-4 is also phosphorylated in yeast cells but not hyphal cells.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Met-1 is acetylated.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6 9 13">Causes greater curvature of cells growing in a filamentous manner and morphological defects in suspensor cells and chlamydospores. Leads to reduced tissue penetration and non-invasive fungal masses in mice infected kidneys. Also leads to hypersusceptibility to caspofungin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710520.1">
        <property type="nucleotide sequence ID" value="XM_705428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1UB61"/>
    <dbReference type="SMR" id="G1UB61"/>
    <dbReference type="BioGRID" id="1230981">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="FunCoup" id="G1UB61">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="237561.G1UB61"/>
    <dbReference type="iPTMnet" id="G1UB61"/>
    <dbReference type="EnsemblFungi" id="C5_00070W_A-T">
        <property type="protein sequence ID" value="C5_00070W_A-T-p1"/>
        <property type="gene ID" value="C5_00070W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647888"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500070WA"/>
    <dbReference type="CGD" id="CAL0000177264">
        <property type="gene designation" value="CDC11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00070W_A"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="InParanoid" id="G1UB61"/>
    <dbReference type="OMA" id="NNGIHIY"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000399">
        <property type="term" value="C:cellular bud neck septin structure"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032168">
        <property type="term" value="C:hyphal septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072687">
        <property type="term" value="C:meiotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006033">
        <property type="term" value="P:chitin localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001410">
        <property type="term" value="P:chlamydospore formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002908">
        <property type="entry name" value="Septin CDC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000424349" description="Septin CDC11">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4 motif" evidence="3">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="318"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Basic motif" evidence="1">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N-acetylmethionine" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="11">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDC28" evidence="11">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by GIN4" evidence="11">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Blocks phosphorylation of Ser-394 and impairs hyphal morphogenesis." evidence="11">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Blocks phosphorylation of Ser-394 and Ser-395 and impairs hyphal morphogenesis." evidence="11">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11454197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12181342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="12819094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15449307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="15659158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="16002645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="17504812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="17765684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="19915075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="22687514"/>
        </source>
    </evidence>
    <sequence length="402" mass="46712" checksum="9D09A5D55B3BC87E" modified="2011-10-19" version="1">MNYSTENVSSAALRKRKTLKKSINFSIMIIGESGSGRSTLINTLCGGNSIVPTSSTATQDPFTKKLTLRHENVELEDNEGHKISLNIIDTPNFANSINCDDDFKIIVDFIRHQFDEVLLEESRVKRNPRFKDGRIHVLIYMINPTGHGLSDIDVKFLQHVNNLVNIIPIISKADSLTPKELKLNKELILEDLNNYGINFYKFNEYDYEQDYIDEEIIEYNKYLNSLIPFAIIGANEYRSNPNGSEDEDDILKLRILNKDFKPIDIDNAEINDFTILKNVLLVTHLNEFKDITHDSIYENYRTEALSGKQFQYVNKDSAKQEISESDYLMKEEQIKLEEERLRKFEERVHQDLINKRKELLERENELKEIEKRLLAEGLKFDENGDVVKVHEEESSENEVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G1UB62</accession>
    <name>G1UB62_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C703040WA</name>
        <name evidence="15" type="ordered locus">orf19.12624</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716979.1">
        <property type="nucleotide sequence ID" value="XM_711886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1UB62"/>
    <dbReference type="STRING" id="237561.G1UB62"/>
    <dbReference type="GeneID" id="3641379"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703040WA"/>
    <dbReference type="CGD" id="CAL0000192634">
        <property type="gene designation" value="orf19.12624"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03040W_A"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="InParanoid" id="G1UB62"/>
    <dbReference type="OMA" id="SEWWLMY"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000192634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW30650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="203" mass="23750" checksum="B77AECA1DC297F46" modified="2011-10-19" version="1">MKGYLILYNSVSAILWGYILFQCFRDWNIGYYEVEEIPHKFMVYTQIFNSSIEIFHSMIGLVPTPIPTLLLQSFARLIIMVGICVVIPESLANYDITVFSGLTLAWSITEVIRYGFYVIKMFGIATPYWLVWLRYSAFLVLYPLGLVCESTTVFNSYDYVKTKIPAYYYFLKYAIVLYIPGFLYLYTYMIGQRTKVLKKIKAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>O74711</accession>
    <accession>A0A1D8PL28</accession>
    <accession>Q59UT0</accession>
    <name>PEX5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Peroxisomal targeting signal receptor</fullName>
            <shortName>PTS1 receptor</shortName>
            <shortName>PTS1R</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PEX5</name>
        <name type="ordered locus">CAALFM_C400150CA</name>
        <name type="ORF">CaO19.13085</name>
        <name type="ORF">CaO19.5640</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Yeast" volume="14" first="1147" last="1157">
            <title>Cloning and sequence of a 3.835 kbp DNA fragment containing the HIS4 gene and a fragment of a PEX5-like gene from Candida albicans.</title>
            <authorList>
                <person name="Navarro-Garcia F."/>
                <person name="Perez-Diaz R."/>
                <person name="Negredo A."/>
                <person name="Pla J."/>
                <person name="Nombela C."/>
            </authorList>
            <dbReference type="PubMed" id="9778800"/>
            <dbReference type="DOI" id="10.1002/(SICI)1097-0061(19980915)14:12&lt;1147::AID-YEA297&gt;3.3.CO;2-Z"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-592</scope>
        <source>
            <strain>ATCC 64385 / 1001</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
        <text evidence="2 3">Cycles between the cytosol and the peroxisome matrix. Following binding to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, recruited to the docking complex, composed of PEX13 and PEX14, leading to translocation into the peroxisome matrix along with cargo proteins. Export and recycling to the cytosol is initiated by binding to the PEX2-PEX10-PEX12 ligase complex via its unstructured N-terminus that inserts into the ligase pore and emerges in the cytosol. Cys-10 of PEX5 is then monoubiquitinated, promoting its extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex (By similarity). Extraction is accompanied by unfolding of the TPR repeats and release of bound cargo in the peroxisome matrix (By similarity). The TPR repeats refold in the cytosol and ubiquitination is removed by deubiquitinating enzyme UBP15, resetting PEX5 for a subsequent import cycle (By similarity).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for PEX5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the PEX2-PEX10-PEX12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Monoubiquitinated at Cys-10 by PEX2 during PEX5 passage through the retrotranslocation channel: monoubiquitination acts as a signal for PEX5 extraction and is required for proper export from peroxisomes and recycling. When PEX5 recycling is compromised, polyubiquitinated at Lys-22 by PEX10 during its passage through the retrotranslocation channel, leading to its degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ003115">
        <property type="protein sequence ID" value="CAA05870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713321.1">
        <property type="nucleotide sequence ID" value="XM_708228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O74711"/>
    <dbReference type="SMR" id="O74711"/>
    <dbReference type="FunCoup" id="O74711">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="237561.O74711"/>
    <dbReference type="EnsemblFungi" id="C4_00150C_A-T">
        <property type="protein sequence ID" value="C4_00150C_A-T-p1"/>
        <property type="gene ID" value="C4_00150C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645026"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400150CA"/>
    <dbReference type="CGD" id="CAL0000177775">
        <property type="gene designation" value="PEX5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00150C_A"/>
    <dbReference type="eggNOG" id="KOG1125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013516_3_0_1"/>
    <dbReference type="InParanoid" id="O74711"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="PRO" id="PR:O74711"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140597">
        <property type="term" value="F:protein carrier chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0882">Thioester bond</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000106308" description="Peroxisomal targeting signal receptor">
        <location>
            <begin position="1"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 3">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 4">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 5">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 1 (AH1)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 2 (AH2)" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 4 (AH4)" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="WxxxF/Y motif 1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="WxxxF/Y motif 2" evidence="1">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="WxxxF/Y motif 3" evidence="1">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="WxxxF/Y motif 4" evidence="1">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A1L8FDW4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P35056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P50542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="592" mass="67324" checksum="FA5B271F220B38E6" modified="2006-01-24" version="2">MSFVGGGSECSVNGNAVAQFNKHTQQDRSLQQQVANQHGNVAQNQGFKKDNLMNVRDRANLDQFMNNGAPQNSFQFQPMRHELNTIQNQPNAIHQQQSNWSQDFVAQSPSAQITTPIAKTGSPVNAQWASEFSQAPATQQHNQRPGQFGPRLGGYRPMMGMSMAYQSQPQQQQQQQHNQEPQVDWENQFKEIEELTNKAEEVEEIQREQSPEIVVDDKYQATFQEVWDSLNSESFENDFINQQYEDFKRTQKDGFPADMNQWEKDFAKYASTRAHFGDYQFEDKQSNQFLDLPKDQDPYEIGLQLMENGAKLSEAALAFEAAIQRDENHVDAWLKLGEVQTQNEKEIAGISALEKCLELHPENSEALMNLAISYINEGYDNAAFATLERWISTKYPQIVEKARQENPTITDEDRFSLNKRVTELFLNAAQLSPNQASMDADVQMGLGVLFYANEEFDKTIDCFKAALSIRPDDAILWNRLGASLANSNRSEEAVDAYFKALQLKPTFVRARYNLGVSCINIGCYKEAAEHLLSGLSMHQVEGVDTVSTLNHNQSTSLTETLKRAFIAMERRDLLELVKPNMDLNQFRGEFSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-10-14" modified="2025-04-09" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>P86029</accession>
    <accession>A0A1D8PLI0</accession>
    <accession>Q5AMS9</accession>
    <name>HQD2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Catechol 1,2-dioxygenase</fullName>
            <ecNumber>1.13.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HQD2</name>
        <name type="ordered locus">CAALFM_C402230CA</name>
        <name type="ORF">CaO19.12036</name>
        <name type="ORF">CaO19.4567</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Arch. Microbiol." volume="187" first="199" last="206">
            <title>Purification and characterization of a catechol 1,2-dioxygenase from a phenol degrading Candida albicans TL3.</title>
            <authorList>
                <person name="Tsai S.-C."/>
                <person name="Li Y.-K."/>
            </authorList>
            <dbReference type="PubMed" id="17089147"/>
            <dbReference type="DOI" id="10.1007/s00203-006-0187-4"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 56-80; 161-169 AND 212-219</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
        <scope>SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <source>
            <strain evidence="3">TL3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Can cleave 4-methylcatechol at lower rates than catechol, but has no activity with 3-methylcatechol, 4-chlorocatechol, 4-carboxycatechol or hydroxyquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>catechol + O2 = cis,cis-muconate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23852"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:32379"/>
            <dbReference type="EC" id="1.13.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="3">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Inhibited by Ag(+), Cu(+), Hg(2+) and Pb(2+).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">9.3 uM for catechol</KM>
            <KM evidence="3">21.5 uM for 4-methylcatechol</KM>
        </kinetics>
        <phDependence>
            <text evidence="3">Optimum pH is 8.0. Active from pH 7.0 to 9.0.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="3">Optimum temperature is 25 degrees Celsius. Stable at temperatures lower than 40 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">By phenol.</text>
    </comment>
    <comment type="mass spectrometry" mass="31994.0" error="2.0" method="Electrospray" evidence="3"/>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.1"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722639.1">
        <property type="nucleotide sequence ID" value="XM_717546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P86029"/>
    <dbReference type="SMR" id="P86029"/>
    <dbReference type="STRING" id="237561.P86029"/>
    <dbReference type="EnsemblFungi" id="C4_02230C_A-T">
        <property type="protein sequence ID" value="C4_02230C_A-T-p1"/>
        <property type="gene ID" value="C4_02230C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635693"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402230CA"/>
    <dbReference type="CGD" id="CAL0000188195">
        <property type="gene designation" value="HQD2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02230C_A"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="InParanoid" id="P86029"/>
    <dbReference type="OMA" id="AMGPKTT"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="SABIO-RK" id="P86029"/>
    <dbReference type="UniPathway" id="UPA00157">
        <property type="reaction ID" value="UER00258"/>
    </dbReference>
    <dbReference type="PRO" id="PR:P86029"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019615">
        <property type="term" value="P:catechol catabolic process, ortho-cleavage"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019614">
        <property type="term" value="P:catechol-containing compound catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.130.10:FF:000005">
        <property type="entry name" value="Catechol 1,2-dioxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000351556" description="Catechol 1,2-dioxygenase">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="4" ref="4">
        <original>SR</original>
        <variation>DK</variation>
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="4" ref="4">
        <original>C</original>
        <variation>Y</variation>
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="4" ref="4">
        <original>I</original>
        <variation>L</variation>
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="4" ref="4">
        <original>T</original>
        <variation>S</variation>
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="4" ref="4">
        <original>D</original>
        <variation>E</variation>
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="4" ref="4">
        <original>E</original>
        <variation>D</variation>
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="4" ref="4">
        <original>I</original>
        <variation>L</variation>
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17089147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="303" mass="33800" checksum="51BA8D5B0C8C6FBA" modified="2008-10-14" version="1">MSQAFTESVKTSLGPNATPRAKKLIASLVQHVHDFARENHLTTEDWLWGVDFINRIGQMSDSRRNEGILVCDIIGLETLVDALTNESEQSNHTSSAILGPFYLPDSPVYPNGGSIVQKAIPTDVKCFVRGKVTDTEGKPLGGAQLEVWQCNSAGFYSQQADHDGPEFNLRGTFITDDEGNYSFECLRPTSYPIPYDGPAGDLLKIMDRHPNRPSHIHWRVSHPGYHTLITQIYDAECPYTNNDSVYAVKDDIIVHFEKVDNKDKDLVGKVEYKLDYDISLATESSIQEARAAAKARQDAEIKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-07" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KC4</accession>
    <accession>A0A1D8PSV7</accession>
    <accession>Q59KD1</accession>
    <name>S2538_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_CR04920WA</name>
        <name type="ORF">CaO19.1804</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710191.1">
        <property type="nucleotide sequence ID" value="XM_705099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KC4"/>
    <dbReference type="SMR" id="Q59KC4"/>
    <dbReference type="FunCoup" id="Q59KC4">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59KC4"/>
    <dbReference type="EnsemblFungi" id="CR_04920W_A-T">
        <property type="protein sequence ID" value="CR_04920W_A-T-p1"/>
        <property type="gene ID" value="CR_04920W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3648207"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04920WA"/>
    <dbReference type="CGD" id="CAL0000196262">
        <property type="gene designation" value="orf19.9370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04920W_A"/>
    <dbReference type="eggNOG" id="KOG0766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_0_3_1"/>
    <dbReference type="InParanoid" id="Q59KC4"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="PRO" id="PR:Q59KC4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000378931" description="Mitochondrial glycine transporter">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="2">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="2">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 2" evidence="2">
        <location>
            <begin position="132"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 3" evidence="2">
        <location>
            <begin position="269"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q96DW6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <sequence length="362" mass="39667" checksum="41B086AF38D5C95E" modified="2005-04-26" version="1">MSSPPLSSPVPQVKTTQNGKSPDATVHLLAGAIAGLVSAVTLQPFDLLKTRLQQQQLTTKQEVRTTLTKELKKLTRVKDLWRGTLPSTLRTSIGAGLYFTTLSKMRTSWGEYKQSKDSSINLKSNSSILPKLTAMENLTTGFIARGIVGYITMPITIIKTRFESNLYNYNSMYEGISGIYLDDKKQQQQIRNPSINKGVGGGGSWKNFFKGSVATLARDCPYAGLYVLTYEAFKNDLIPLIIPNSSLSLSSSSSLSSSSSLFVFNDNNRSSIINSTAAVLAASTCTTITAPFDAIKTRLQLTNEEGGSMTTVLKKMLREDGGIKNLFRGLSLRLGRKGISAGISWCIYEELIKSNYFQSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q59M32</accession>
    <name>Q59M32_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial 54S ribosomal protein YmL15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C112610WA</name>
        <name evidence="2" type="ordered locus">orf19.11239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710785.1">
        <property type="nucleotide sequence ID" value="XM_705693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59M32"/>
    <dbReference type="SMR" id="Q59M32"/>
    <dbReference type="FunCoup" id="Q59M32">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59M32"/>
    <dbReference type="GeneID" id="3646825"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112610WA"/>
    <dbReference type="CGD" id="CAL0000201122">
        <property type="gene designation" value="orf19.11239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12610W_A"/>
    <dbReference type="eggNOG" id="ENOG502RXWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088025_0_0_1"/>
    <dbReference type="InParanoid" id="Q59M32"/>
    <dbReference type="OMA" id="LHKGPRV"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000052">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="220" mass="24641" checksum="77EEC0BCF3542448" modified="2005-04-26" version="1">MIGNIRQLSSRITGQQFTIFTRSIYLHKGPRVEGLKRDPEAAFINPKGIKYGLNETNISHIKSFLGDKYNIPDEIALQVITHKSFGNGIKPYNEKLAAMGSKLLSLYFAKYVTNQPCKHDNGVEGKNLDVLGSPMSRELPSLKTAAIFAKSNNINEIMFWHTRNSTLGFESSGELKVSGELLFSLVGAVNFYHGKNKAEQFITEKLVDQFEKISAQNIRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q59M70</accession>
    <accession>A0A1D8PPU2</accession>
    <name>MCR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>NADH-cytochrome b5 reductase 2</fullName>
            <ecNumber>1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Mitochondrial cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MCR1</name>
        <name type="ordered locus">CAALFM_C602040WA</name>
        <name type="ORF">CaO19.11001</name>
        <name type="ORF">CaO19.3507</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710845.1">
        <property type="nucleotide sequence ID" value="XM_705753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59M70"/>
    <dbReference type="SMR" id="Q59M70"/>
    <dbReference type="BioGRID" id="1230654">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59M70">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59M70"/>
    <dbReference type="EnsemblFungi" id="C6_02040W_A-T">
        <property type="protein sequence ID" value="C6_02040W_A-T-p1"/>
        <property type="gene ID" value="C6_02040W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647561"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602040WA"/>
    <dbReference type="CGD" id="CAL0000182452">
        <property type="gene designation" value="MCR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02040W_A"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="InParanoid" id="Q59M70"/>
    <dbReference type="OMA" id="KGPEMQK"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="PRO" id="PR:Q59M70"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000330176" description="NADH-cytochrome b5 reductase 2">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="301" mass="33460" checksum="7F16134D770DBDFB" modified="2005-04-26" version="1">MLTHHLSKLATPKFLVPFAGATALSIGLALQYSTSNNYIANETGKTFTDSNEWVDLKLSKSIDLTHNTKHLVFKLKDENDVSGLITASCLLTKFVTPKGNNVIRPYTPVSDVNQSGEIDFVIKKYDGGKMSSHIFDLKEGETLSFKGPIVKWKWEPNQFKSIALIGGGTGITPLYQLLHQITSNPKDNTKVNLIYGNLTPEDILLKKEIDAIASKHKDQVKVHYFVDKADEKKWEGQIGFITKEFLQKELEKPGSDFKVFVCGPPGLYKAISGPKVSPTDQGELTGALKDLGFEKEHVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NG8</accession>
    <name>Q59NG8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">NHX1</name>
        <name evidence="14" type="ordered locus">CAALFM_C600570CA</name>
        <name evidence="13" type="ordered locus">orf19.11677</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711253.1">
        <property type="nucleotide sequence ID" value="XM_706161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NG8"/>
    <dbReference type="SMR" id="Q59NG8"/>
    <dbReference type="FunCoup" id="Q59NG8">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59NG8"/>
    <dbReference type="GeneID" id="3647141"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600570CA"/>
    <dbReference type="CGD" id="CAL0000198193">
        <property type="gene designation" value="NHX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00570C_A"/>
    <dbReference type="HOGENOM" id="CLU_005912_5_1_1"/>
    <dbReference type="InParanoid" id="Q59NG8"/>
    <dbReference type="OMA" id="FTYVRRF"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="60"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000198193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW30005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="663" mass="73298" checksum="58595D683CAEF5E9" modified="2005-04-26" version="1">MSSLTIYAAKILLKRAISGDLEEDTPDLTTPDDAEDSNPVENEIFSSWALFILLFLLMSALWSSYFLQQRRIKAVHETVLSIFCGMIVGLIIRMSPGHYIQDAVKFNPGYFFNILLPPIILNSGYELHQANFFRNLGSILTFAIPGTFISALVVGIILYIWTALGLDNVSLEFVDALAVGATLSATDPVTILSIFNAYKVDPKLYTIIFGESLLNDAISIVMFETCQKFHGQPVRFSSFFQGVGLFLMTFTISTIIGIFIGILVALILKHSHIRRYPQIETCLVLLFAYQSYFFSNGAHMSGIVSLLFCGITLKHYAYFNMSRRTQIATKYIFQLLAQLSENFIFIYLGLSLFTEVELVFKPMLIIVAFIAICVARWSAVFPLSRFLNFFYRTRFERYSAGTLSTSAGNMINMPDEISHSYQMMIFWAGLRGAVGVALAMGFSGEAKWTLLATVLVVVVLTVILFGGTTASMLEILGIKIGCVDESGDFSDDEFDIEAPPRFPQQSQQSNISSVANKNQNIYGNRRFARSSKLSNYKDNLSAVNLLDQEHGGVPNTGNSSTSNFANVNDDDDDDEIVGSDVDDFISGSISNSTSNINNNNDRGGVLGAILSAEEHAKWFTRFDEEVLKPVLLDTLPSTGQSSQNNSTSNLNSSGNGNGKRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QC1</accession>
    <name>Q59QC1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C108520CA</name>
        <name evidence="8" type="ordered locus">orf19.8027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711885.1">
        <property type="nucleotide sequence ID" value="XM_706792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QC1"/>
    <dbReference type="SMR" id="Q59QC1"/>
    <dbReference type="FunCoup" id="Q59QC1">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59QC1"/>
    <dbReference type="GeneID" id="3646495"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108520CA"/>
    <dbReference type="CGD" id="CAL0000197867">
        <property type="gene designation" value="orf19.8027"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08520C_A"/>
    <dbReference type="eggNOG" id="KOG4778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126124_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QC1"/>
    <dbReference type="OMA" id="DYAYKAP"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000197867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="147" mass="17164" checksum="FDC62182D91A6126" modified="2005-04-26" version="1">MFNPLNKPTTTSNVIKHFVRGKRQATELNIATQKIVNQLSVLSASRKQPKLLKLCNEDFIKHKTIMNAWKLLQRRRITQQSEKLSKQYKSIVNAMEDLKQTSPELFEAANAKNPKRFTTFPIEMRVPTDYPPNKPWTYNFVPSKTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QT2</accession>
    <name>Q59QT2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Actin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">ARP1</name>
        <name evidence="9" type="ordered locus">CAALFM_C503380WA</name>
        <name evidence="8" type="ordered locus">orf19.10164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712024.1">
        <property type="nucleotide sequence ID" value="XM_706931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QT2"/>
    <dbReference type="SMR" id="Q59QT2"/>
    <dbReference type="STRING" id="237561.Q59QT2"/>
    <dbReference type="GeneID" id="3646349"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503380WA"/>
    <dbReference type="CGD" id="CAL0000177256">
        <property type="gene designation" value="ARP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03380W_A"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="Q59QT2"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="PHI-base" id="PHI:11135"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000177256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="414" mass="46742" checksum="EC83D0A87161BB54" modified="2005-04-26" version="1">MAEILYNQPVVIDNGSGNLKAGFAGEDKPKSYASAIIGRPKYQKIMAAGSTSLLSEQQSHDQLFIGNSAQDNRGLLKLSYPIEHGIVNNWSDMEKLWYHTYTQDLKTQSEDHPLLITEAPLNPRSNRNKMCQILFENFNIPCIYISIQAVLSLYASGRTTGVVIDSGDGVTHVVPVYEGFALPPSIKRMDIAGRDITESLAFNIRRMTGVALQSSSELEIVRLIKEQNCFISKDPVRDEKKYGSHYSRNNPNNELMSTYKLPDGHEIQLGVERFRATEILFNPQLIGHESPGIHELTSLAIAKTDLDLRSTLYQNIILSGGNTLLKNFGDRMLKELKDLQQPLQEDQKMSIWNKNVQNDVYNTKMKVKIYAPPERKYSTWIGGSILAGLSTFKKMWVTSEEYHENPDIVHVKCM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RR3</accession>
    <accession>A0A1D8PTH7</accession>
    <name>MNL1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>MSN2- and MSN4-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MNL1</name>
        <name type="synonym">MSN2</name>
        <name type="ordered locus">CAALFM_CR07450CA</name>
        <name type="ORF">CaO19.13540</name>
        <name type="ORF">CaO19.6121</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="1111" last="1123">
            <title>Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Nicholls S."/>
                <person name="Straffon M."/>
                <person name="Enjalbert B."/>
                <person name="Nantel A."/>
                <person name="Macaskill S."/>
                <person name="Whiteway M."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15470239"/>
            <dbReference type="DOI" id="10.1128/EC.3.5.1111-1123.2004"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="4393" last="4403">
            <title>MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Ramsdale M."/>
                <person name="Selway L."/>
                <person name="Stead D."/>
                <person name="Walker J."/>
                <person name="Yin Z."/>
                <person name="Nicholls S.M."/>
                <person name="Crowe J."/>
                <person name="Sheils E.M."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="18653474"/>
            <dbReference type="DOI" id="10.1091/mbc.E07-09-0946"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_707235.2"/>
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    <dbReference type="EnsemblFungi" id="CR_07450C_A-T">
        <property type="protein sequence ID" value="CR_07450C_A-T-p1"/>
        <property type="gene ID" value="CR_07450C_A"/>
    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_CR07450CA"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07450C_A"/>
    <dbReference type="eggNOG" id="KOG1721">
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        <property type="component" value="Chromosome R"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="zf-C2H2"/>
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    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000426086" description="Transcriptional regulator MNL1">
        <location>
            <begin position="1"/>
            <end position="905"/>
        </location>
    </feature>
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            <begin position="832"/>
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    </feature>
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            <begin position="861"/>
            <end position="883"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="15470239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18653474"/>
        </source>
    </evidence>
    <sequence length="905" mass="100509" checksum="C9E1C9EA2EF8A1AE" modified="2017-03-15" version="2">MDSHNNIDQSVSELLSDPASVQQSYNSQLRGPEFDQQRQIRNQVSPFNKMTDTIDNDNIPLSSDYDKLYQQFSIPSQQQYENNSDNVYKTNNDLAALASPLNMDLDLAPSDQQQQPQQSQQQFLNDFSNLQPHLNNSQEQVQLNGLTSNILSNPQITVNMPGAYHQNYNCDQMEIDDSPPFTIESDLYFEQQTDNNSIVTSNRVHNQPDVESMFNNQLSVPSLQRTELSPQQHETNVTTGRPQESAFGSFDNNSRVSSFANVNNAGTNLFVNGKDLYFDDESHHRTGRLRNGSIDSYYAANVINHQLHLQQQTQAQAQAHQQQQQQSQQQHSPQDLASHTSLPSKSIYNELSPLTTTTSRASSIQSGQPSFFSAQQYFSRNSMDQVPSSLHRPSFDLYNHRPSIDSQHSQQSQQRNARYTSFTSSISNILPFMSEKNTNHNNRSPPTPPTSTSSPQNLLSSNQSRHLIRSIFKTNPTPIVSDAGNSNGNIVNGGSGTIDAENLPDAPYASGTINDSEFLILSSPTKEEPEDELMQPKKVKKPKRSLFTRFKTPVKQEQPDSEMAVSAPVDELKPDETVIDMVGNISSHHSSGTPSITTGAGGNTLEHSISESSFQEPDYAALFENVGKRKNKSYRKPKGKTKEEEQQQQQLPLSSGTAGGTSSNNSTGTVEKTLFFNKTKIKKEPASERSSLLDNASAGNASASSSEASSIQNAIGSDDHNGPPLTSAPTSSTLANASKRILSSKLISKKKSTSKLKEYTAAELEDMCTVSSLETPVATMISKGIEVEVDLASLDLPPDTKIFPTSIINNKNRTRGRKENKEADLSDTSKIYLCNLCQRRFKRHEHLKRHFRSLHTFEKPYNCDICHKKFSRSDNLNQHLKIHKQEDEKDCADAETGVGMDDASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SD0</accession>
    <name>Q59SD0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory particle lid subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPN12</name>
        <name evidence="5" type="ordered locus">CAALFM_C208930WA</name>
        <name evidence="4" type="ordered locus">orf19.7845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707504.1"/>
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    <dbReference type="FunCoup" id="Q59SD0">
        <property type="interactions" value="1300"/>
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    <dbReference type="eggNOG" id="KOG3151">
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    <dbReference type="InParanoid" id="Q59SD0"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="C:proteasome storage granule"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
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    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="76"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000184969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="277" mass="32138" checksum="3EC3357630D5C998" modified="2005-04-26" version="1">MSLQKLTAEIYSLFGKGDYQGCQQLLAPIKLELVKHDLLVPLPSNTTDKNQINDLRIAQRILEIGALSSLLTNNYSGFENYFAQLRPFYSNPKLHNLQKVHINTDITKIISLYLLYLLSQGLISKFHVELEVIYNSSQYDAQQDKYLQFPINLESNLMEGNYIKIWKLLKEEKNLPCQEYTHFVDTLINALRFEIAKSLEKTYDSIPISNCKNLLYLPQELSDANFEKTLKETYQVDNWKFEDGVIYFTKNENETNVDNQSVIKNLLGYAEQIESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T32</accession>
    <name>Q59T32_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nem1-Spo7 phosphatase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">SPO7</name>
        <name evidence="4" type="ordered locus">CAALFM_C205740WA</name>
        <name evidence="3" type="ordered locus">orf19.14174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712814.1">
        <property type="nucleotide sequence ID" value="XM_707721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59T32"/>
    <dbReference type="STRING" id="237561.Q59T32"/>
    <dbReference type="GeneID" id="3645576"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205740WA"/>
    <dbReference type="CGD" id="CAL0000190675">
        <property type="gene designation" value="SPO7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05740W_A"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030111_0_0_1"/>
    <dbReference type="InParanoid" id="Q59T32"/>
    <dbReference type="OMA" id="RHMEINQ"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000190675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="514" mass="57829" checksum="AD98074AFBC1C832" modified="2005-04-26" version="1">MSNSIGFEEENDTACDATSKVKQSRSASSLNSSSSRRNSLERMSHDEGISSPTSSINYMSSSSTKSPPPSPPKSPRLENTKKMFKMMSITSPMGSSSESVVLSDSDERSSLELQERGTITPSRHMEINQSSDEDDTEFDSTRLRFSARKGRRKSGTDEESPSKRSIKLSRGASPARKGRRRGSSPSPHSDTNTQGKSSSTSKRKLRRKSKESDKSHRSEFFGTGYTSMPTSGKVFRNLLILEENLREQVIQQRAMRRKYLTFLSILCSIIAALSHHLFFLDNSSTGTLKVILQFCLLATIVTLMLYHLSGEYQKTIVLPRRFLSSTNQGLRQLNVRLVKIKTPFFDKLTDLIREISLAIVNFNLSVFHKLSPESIQNKNSKIEVFLVTCQSQCQPRIGVTDVKLVLNARVFNTDIREGWEMYRSEFWINEGIRRRNNMLSFISGSPVAKPVGLKRRKRKSENNDSSIKPKSIPASLSEQNLQVLSSGFEYNNDNNVDLRSETSSPLRSDTLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T89</accession>
    <name>Q59T89_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TFIIH complex kinase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C101820CA</name>
        <name evidence="5" type="ordered locus">orf19.12017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712967.1">
        <property type="nucleotide sequence ID" value="XM_707874.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59T89"/>
    <dbReference type="SMR" id="Q59T89"/>
    <dbReference type="FunCoup" id="Q59T89">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59T89"/>
    <dbReference type="GeneID" id="3645435"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101820CA"/>
    <dbReference type="CGD" id="CAL0000186980">
        <property type="gene designation" value="orf19.12017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01820C_A"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_2_1"/>
    <dbReference type="InParanoid" id="Q59T89"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000128">
        <property type="entry name" value="TFIIK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000186980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW25869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="395" mass="45892" checksum="082086DD4472E696" modified="2005-04-26" version="1">MSEVKNELETETTPAPAKKQRLSNDDLYRNSTQYELWSFTQETLQDAKREANEKGVKISKERFKSAFENAKKEHPDAFEQFPDELNENMVSLLTLEEESTYLDFYIQNITTTCNFFKMPTQVRLTAASFFKKFYLVNSVMEFHPKNVLYTCIFLAAKSENYFISIESYVKALKGTDTSHILDLEFIVLQSLKFTLLVHHPIRALYGFFLDFQAVLLHPEQVMYDVSVDTLGNMYNQAKEWLNKYFMVSDVAFLFTPPQIALAAMYDTDKRITDKYLRRKYLGNEEKLDPIKEQENENEKQNGEDKSVVASEEASKDVSKEKTKSSNRQQYETLVTLLRKCVKLAKQSRVADREASKEIDKKCFFALNPKKLIDKRIKRLTLGNQDVAKESTVEPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TE0</accession>
    <name>RL17B_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L17-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL17B</name>
        <name type="synonym">RPL17</name>
        <name type="ordered locus">orf19.4490</name>
        <name type="ORF">CAALFM_C204600CA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712916.1">
        <property type="nucleotide sequence ID" value="XM_707823.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="x=1-185"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="x=1-185"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="x=1-185"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="x=1-185"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="x=1-185"/>
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    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="BK/x=1-185"/>
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        <property type="resolution" value="3.10 A"/>
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    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="BK/x=1-185"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="BK/x=1-185"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="BK/x=1-185"/>
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    <dbReference type="PDB" id="9G1Z">
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    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="x=1-185"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="x=1-185"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
    <dbReference type="PDBsum" id="7Q0R"/>
    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="Q59TE0"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="Q59TE0"/>
    <dbReference type="FunCoup" id="Q59TE0">
        <property type="interactions" value="1082"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59TE0"/>
    <dbReference type="EnsemblFungi" id="C2_04600C_A-T">
        <property type="protein sequence ID" value="C2_04600C_A-T-p1"/>
        <property type="gene ID" value="C2_04600C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645439"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204600CA"/>
    <dbReference type="CGD" id="CAL0000193181">
        <property type="gene designation" value="RPL17B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04600C_A"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_0_1"/>
    <dbReference type="InParanoid" id="Q59TE0"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456517" description="Large ribosomal subunit protein uL22">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="185" mass="20963" checksum="CC95976D878D2694" modified="2005-04-26" version="1">MVRYAATPANPAKSASARGSYLRVSFKNTRETAQAINGWKLEKAQKYLDQVLDHQRAIPFRRYNSSIGRTGQGKEFGVTKARWPAKSVNFVKDLLRNAQANAEAKGLDSSKLVISHIQVNHAPKQRRRTYRAHGRINAYQSTPSHIELTLTEEDEIVEKPVEQKQIRLNSRQRGRLASQKRLTAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VC6</accession>
    <accession>A0A1D8PT75</accession>
    <accession>Q59V81</accession>
    <name>DAD3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DAD3</name>
        <name type="ordered locus">CAALFM_CR06160CA</name>
        <name type="ORF">CaO19.11352</name>
        <name type="ORF">CaO19.3871</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713496.1">
        <property type="nucleotide sequence ID" value="XM_708403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VC6"/>
    <dbReference type="SMR" id="Q59VC6"/>
    <dbReference type="BioGRID" id="1227903">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VC6"/>
    <dbReference type="EnsemblFungi" id="CR_06160C_A-T">
        <property type="protein sequence ID" value="CR_06160C_A-T-p1"/>
        <property type="gene ID" value="CR_06160C_A"/>
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    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
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    </feature>
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        <location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
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        <source>
            <dbReference type="UniProtKB" id="P62505"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="UniProtKB" id="P69850"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    <sequence length="138" mass="15466" checksum="386366B8999B614A" modified="2017-03-15" version="2">MSFTTKDKSDDSSIITTNYADNPNLSPIEQKILQQYQLMNNNLIKVSNELELLTNTTDEFGKGKGSSIHLVENLRQLETKLVFVYTFFKGAVYSILNAQDYIAEQETNGLEETNEEEDGNEEDESGNVELSGVSADEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP017623">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_708713.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="356"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000177129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="369" mass="41174" checksum="D66994F70B5336A7" modified="2005-04-26" version="1">MENNNTIPALFQPIKISDSITLPNRIGVSPMCMYSSSPTDNQATSFHFVHYGSFAVRGPALIILESIFVSENSGLSIHDLGLWNDDQAHSLRKIVDFIHDQDGICCIQLNHAGRKIVEGVPFQQIQHGWQEHCVGPSTEPFSDSHNTPRELTVNEINSIVEDFANAAWRAVEISKFDAIEIHCANGCLIHQFLSKLTNKRADQYGGSFENRVRFLLQIIENIKRKIETPIFLKFPMSDNCSDPEAWSTEDALKLADLVIDLGVKVIDVTSGGNVAHCKSRYLLNDDKQLPSQVPLARKLKSHIRNRCLIACSGGLDRDIFKLDEFIANGDFDIALIGKGFLKNTGLISRIADQLQAQFRTAPQYKLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WF2</accession>
    <name>Q59WF2_CANAL</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C110710CA</name>
        <name evidence="8" type="ordered locus">orf19.9886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713954.1">
        <property type="nucleotide sequence ID" value="XM_708861.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WF2"/>
    <dbReference type="SMR" id="Q59WF2"/>
    <dbReference type="FunCoup" id="Q59WF2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WF2"/>
    <dbReference type="GeneID" id="3644407"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110710CA"/>
    <dbReference type="CGD" id="CAL0000192014">
        <property type="gene designation" value="orf19.9886"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_10710C_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000397">
        <property type="entry name" value="Aminotriazole resistance protein"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
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            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="277"/>
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        </location>
    </feature>
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            <begin position="353"/>
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        </location>
    </feature>
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        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000192014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="520" mass="56655" checksum="F053E43FDF115EE4" modified="2005-04-26" version="1">MSDCTSSNSVSVEEFNPDPVNELEKKESNVTVTTVSQLPEPNYENISVIREILFMFFMCMSQLLTQAAVSQTMNTQLKIADTYSIQDDPGEMSWFAASFSMTAGTFILVSGRLGDMYGYKLLYIIGYLWFGVFSLLCGFAGLTKSNVFFTTMRGLQGIGPALMMPNSQALIASFYPESLKKNVCLALFGAIAPSGFVVGALFSGLLADLAKWQWTFWLCGIVSIGLAALAFFIIPKKIGLKSSGKFDFWGSLFGVSGLVLINFAFNQGPNIGWHVPYVYVLLIVGFLCIVAFHFVEERVEDPLVPKEALQGDTGFILGCIAAGWSCFGVWLFYTLRWSLVVDNDNAVMSGVKMIPCGPMGVVAAIGGAILLMKVPSAVVMFLAMMAFFIGIVIMGTRPVGQIYWAQKFVSLLIQPIGMDMSFPAACILLSSSLPRHQQGIAGSLVSTFVNYSISIGLGFAGTVEYYTTKNKEPNLSTSIFGMRNAFRMGMGLAGVGVVLSSIFMLLQIINRRKSTRSQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YG7</accession>
    <name>Q59YG7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TUG ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C209930WA</name>
        <name evidence="4" type="ordered locus">orf19.8939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714533.1">
        <property type="nucleotide sequence ID" value="XM_709440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YG7"/>
    <dbReference type="SMR" id="Q59YG7"/>
    <dbReference type="STRING" id="237561.Q59YG7"/>
    <dbReference type="GeneID" id="3643824"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209930WA"/>
    <dbReference type="CGD" id="CAL0000174689">
        <property type="gene designation" value="orf19.8939"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09930W_A"/>
    <dbReference type="eggNOG" id="ENOG502S0EM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521749_0_0_1"/>
    <dbReference type="InParanoid" id="Q59YG7"/>
    <dbReference type="OMA" id="ERIMLIW"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000174689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="583" mass="67602" checksum="3856B88565DF77DC" modified="2005-04-26" version="1">MCSPTISHLLQVVSIGQDLNSLKFFFFVHTNYNRQFSILLLFVNDLPLNHYNPIFTTQFTMSSSSSPTINFFINYNQPLQGKKITVPKSTSINQLILQALTVYKIDPNNYEGQLYHNGKLLDGSLPIRLTNLLNNAKLNLKTIPKSNSSTNVDTTTNTGSANHHKINVKFINDDTGSSKVQKCSSGLNLIELIEKFNGDISRQSDLRIVNVIIESEKYRETTLESIVGKSNNVVVRLKYRKIDNDDNDRMVKEKQEEAIRLHIEQESIRKKKVHEQEKVEQSLKEQQQQQQQQQVQQQQQEQQDNKNVDAVEDAIIEDPKEDLPHEVSSSNERQAIQPKQENLSHPTIVQPQQYTFQEEEIKDTPQLYIPSNKQQALYENPDEDYELTLNQAKTYQNMIRDSAKRKPKSKGDKPISLPNKYQIRIKFPDASILQINFIENVHEIKFGNLIKKIDELLLPKFINIYNLKHGHPPFKTIDMSYSNNNEYLYNLPDFQQERIMLIWELQKPDLNLKGPYIKNDNLNIKQSEELPERVLERHRGELPSGTDNEKRVNTPRSNTTTTTTDNDSKSTKKPKVPKWFKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZI2</accession>
    <name>Q59ZI2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Sulfiredoxin</fullName>
            <ecNumber evidence="4 14">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAALFM_C205060CA</name>
        <name evidence="18" type="ordered locus">orf19.11021</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="4 14"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714896.1">
        <property type="nucleotide sequence ID" value="XM_709803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZI2"/>
    <dbReference type="SMR" id="Q59ZI2"/>
    <dbReference type="FunCoup" id="Q59ZI2">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZI2"/>
    <dbReference type="GeneID" id="3643451"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205060CA"/>
    <dbReference type="CGD" id="CAL0000196707">
        <property type="gene designation" value="orf19.11021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05060C_A"/>
    <dbReference type="eggNOG" id="KOG3388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124532_1_1_1"/>
    <dbReference type="InParanoid" id="Q59ZI2"/>
    <dbReference type="OMA" id="SQIRRPI"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032272">
        <property type="term" value="P:negative regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017267">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="16">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000196707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW27524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="132" mass="14835" checksum="359C50934235289E" modified="2005-04-26" version="1">MSMYTSRLATEYVPLSEIKRPIPPVLDYQKIDAMLSTLKGVPMESATCKVEDITAGELPPIDVFKIRENGKNFYFAFGGCHRFQAYDRISKETEKEVMVKSRILPATRKSLRIYLGASVDALFDSVDSESSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A246</accession>
    <accession>A0A1D8PSD1</accession>
    <accession>Q5A1Z6</accession>
    <name>RPC3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName>RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPC82</name>
        <name type="synonym">RPC3</name>
        <name type="ordered locus">CAALFM_CR02890CA</name>
        <name type="ORF">CaO19.10366</name>
        <name type="ORF">CaO19.2847</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715778.2">
        <property type="nucleotide sequence ID" value="XM_710685.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A246"/>
    <dbReference type="SMR" id="Q5A246"/>
    <dbReference type="FunCoup" id="Q5A246">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A246"/>
    <dbReference type="EnsemblFungi" id="CR_02890C_A-T">
        <property type="protein sequence ID" value="CR_02890C_A-T-p1"/>
        <property type="gene ID" value="CR_02890C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642585"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02890CA"/>
    <dbReference type="CGD" id="CAL0000174854">
        <property type="gene designation" value="orf19.10366"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02890C_A"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010734_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A246"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="PRO" id="PR:Q5A246"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000351029" description="DNA-directed RNA polymerase III subunit RPC3">
        <location>
            <begin position="1"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine-zipper">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="595" mass="68319" checksum="23DE3CF7069DCCC8" modified="2005-04-26" version="1">MDEVQMETARIQSPKSYLYTTLATTHLGEIASCIISILISNGRLTAREISNRTKIPTKNIKSALVSLIQLNCIYYWQEEKDRKFYYSLKETGLLLFVYSGDIINHIKRQYGEDEAEIIQNILIHGHVKIEDYLTQFNHDKSMKIDQENKFLKLFNDNWLIKLQDYHFHSLDDIWHKIFEECLKDTPRSSVTSEIKRVAEAQAKAKVKLNTLLESGTTGGGDIFTEVNGMKKLKPDLVVTFNLSRFQKHLRTNAFVNMVRSKIGVLTAIVYDAALRYIENKSPPMDYPLLDIPGLINDPKDVKEYILSIENKLVNEKKITFSARDIQRLLPKDIDFKNSVITPTFAKPKRPLENGSSPTLKKIKLEDGIASSTSTSTSTSSSTSSNGTSIDLNTLEQHLKLLLNGTNTAFVNEISPGNYTIPFSHLTNILKQNNFEALVKATLGDYAFRILRCVKSMKLCDEKSICNGALLKEKTVRSELYHLIKANIIEIQEVPRSADRAASKTFYLFRHKSNSNFNYLKNCLIYDMAEILNRIQDFKLEHKILLEKYKLVEGQEDQYLLDRELKLLNDLQLREIKNLVKFQRIKSLYSLYSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A322</accession>
    <name>Q5A322_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U4/U6-U5 snRNP complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">PRP8</name>
        <name evidence="10" type="ordered locus">CAALFM_CR08660WA</name>
        <name evidence="9" type="ordered locus">orf19.13800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716279.1">
        <property type="nucleotide sequence ID" value="XM_711186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A322"/>
    <dbReference type="SMR" id="Q5A322"/>
    <dbReference type="FunCoup" id="Q5A322">
        <property type="interactions" value="1388"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A322"/>
    <dbReference type="GeneID" id="3642125"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08660WA"/>
    <dbReference type="CGD" id="CAL0000198077">
        <property type="gene designation" value="PRP8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08660W_A"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="InParanoid" id="Q5A322"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:metallopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:second spliceosomal transesterification activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:U6 snRNA binding"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:filamentous growth of a unicellular organism"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mRNA 3'-splice site recognition"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mRNA 5'-splice site recognition"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
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        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
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        <property type="entry name" value="PROCT"/>
    </dbReference>
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        <property type="entry name" value="PRP8"/>
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    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
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    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
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        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
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    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2182"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000198077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2416" mass="279882" checksum="F2F51AC2F691A84F" modified="2005-04-26" version="1">MGRKLPPPPPPPGISNKNKRRKENDGKPITENSNGAGKQQLPPPPPPPSSSQSLNSKLRPPPPPPPPPPPSADSKKQSAPSTSLENEQEPRKRTWSNVVKSRRQKKSDTKRSATQVIPQKPEMPPQHLRKIMIDHGDLTSNKIASDKRSHLGSLKYLPHALLKLLENMPQPWEQQKEVKVLYHTTGAITFVNEIPRVIEPVYIAQWATTWNMMRREKKDRKHFKRMRFPPFDDEEPPLDWLENLDDTELVDAIRSKEIEDDDELRDWFYDTRPLVEDPDIVNGDSYRKWNLDFGTMNKLYQLSRPILHEGQTQKFDKNSLFTAKSLNVAIPGGPKFEPLFKDKINNPELEDFTEFNSVDRIIFRQPIKTEYKVELPFLYNSFVKKVSVSPLGAPLDCRSQQPQSKGLPAFTFNPKFNLIVPKTQPKKSEDKDDDDDDNNDFALDVEPFLSWTTTEETNDIEEFGEVPVEPKGTADALDLFFAPYPFNRRRGKTIRAQDAALTKDWYLHQAPKSSNTKVRVSYQKLLKNYVLNEVHKRPNSRRRSHKNKHQKLLRSLKMTKYFQQTTIDWVEAGIQVCRQGFNMLNLLIHKRGLTYLHLDYNFNLKPTKTLSTKERKKSRFGNAFHLIRELLRAVKMIVDSHIQYRLGNVDAYQLADGLYYLFNHLGQLTGIYRYKYKVMHQIRQCKDLKHIIYQRFNKVIGKGPGCGFWQPAWRVWLFFLRGIIPLLERWLGNLIARQFEGRRQNDVAKTITKQRVDAYYDIELRAQVMHDILDMIPEGLKQSKSKTVLQHLSEAWRCWKANIPWKVPGLPKPIESIIERYIKAKADGWISVAHYNRERIRKGAHVEKTVARKNLGRLTRLWIKNEQERQMNFGKNGPFVSPDEGVKIFQTMVSWLESRKFNPIPFPPISYKHDTKLLVLALENLKESYSANAKLNSAQREELALIEQAYDNPHECLVRIKKFLLTQRIFKEVGLEMMDYYSHLVPTYSVDPLEKITDAYLDQYLWYEADKRRLFPNWVKPSDDEIPPLLVYKWCQGINNLHSVWNTSAGECGVMLETSLNKFSENIDFTLLNRLLRLIMDTNIADYITSKNNVSLTFKDMNHVNQYGIIRGLQFASFVYQYYGLVVDLLILGLDRALEIAGPVQNPNNFLQFKDLETETASPIRLYSRYLDKIHIFFQFDNEEASGLIQDYLSEHPDPNFENVVGYNNHRCWPRDSRMRLMRHDVNLGRATFWEISGRIPTSLTSIEWEDSFASVYSRDNPNLLFSMCGFEVRILPKIRAKELSSSQEGVWDLVDQNTRERTAKAFLQVSQEAVDHFHNRIRQILMSSGSTTFTKVAAKWNTALIALVTYYREAAIATPSLLDVLVKCETKIQNRVKMGLNSKMPSRFPPAVFYTPKELGGLGMLSASHILIPASDLRWSKQTDTGITHFRAGMTHQDEKIIPTIFRYVTSWENEFLDSQRVWAEYAIKRQEAIEQNRRLTFEDMENNWDRGLPRISTLFQKDRHTLAYDKGHRIRREFKQFSLARFNPFWWTSNHHDGKLWNLNAYRTDVIQALGGIETILEHTLFKGTGFDSWEGLFWEKASGFEDSLKFKKLTNAQRQGLSQIPNRRFTLWWSPTINRANVYVGFLVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVVQDICQVLDKELEVLQIDNVEKQAIHPRKSYKMNSSTADIVLTSTYKWKVSKPSLLNEKDDKMEIPATTFWIDVQLRYGDYDSHDISRYARSKFLDYTTDGMSSYPSPTGIIIAIDLAYNMYDVYGNWFPGLKPLVHNAMREIMKANPALYVLRERIRKGLQLYQSQPQEAFLNSNNYAELFNNDTQLFVDDTNVYRVTVHKTFEGNLATKPINGCIFILNPKSGQLFLKIIHTSVWSGQKRLGQLAKWKAAEEVAALVKSLPREEQPKQLIVSRRGMMDPLEVHMLDFPNISIRPSELHLPFAAVMKIDKLSDIVLKASEPQMVLFNFYDDWLKSISPYTAFSRVILILRALNIDTETANHILRPSANIVTQDHHIWPSLSDEQWVDVEAQLRDLILSDYSKKYNVNIQSLTQSEVRDLILGQDIRAPSVKRQEIAEIEDGKSNNQVENKELTALKTTTTNVHGEEITTVTTTNYEQSTFSSRNEWRNRAIAANNLHLRAKNIYVSSEEFVDDENSFTYILPKNILQKLIQISDLRIQVGAFLYGKSPADHVGVKEIKCIAIVPQLGNVNSIQFPNTLPDQVGYLKDLELLGWVHTQSQEFSYMTSFDITTQSRFFDEYKPNFVTMTVAYTPGSVTVSSFEITKEGFDWGRTNNDMMSETPSGFSKDYAKKNQLIMSDKIAGTFMVPDDDIWNYFFMGAIFNAAELYDLKLDIPLTFYDELHRPIHFSNFTHIEAGNEEEANQEDVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3K5</accession>
    <name>Q5A3K5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kip4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">KIP4</name>
        <name evidence="5" type="ordered locus">CAALFM_C112010CA</name>
        <name evidence="4" type="ordered locus">orf19.12730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716334.1">
        <property type="nucleotide sequence ID" value="XM_711241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3K5"/>
    <dbReference type="SMR" id="Q5A3K5"/>
    <dbReference type="STRING" id="237561.Q5A3K5"/>
    <dbReference type="GeneID" id="3642032"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112010CA"/>
    <dbReference type="CGD" id="CAL0000181337">
        <property type="gene designation" value="KIP4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12010C_A"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_17_0_1"/>
    <dbReference type="InParanoid" id="Q5A3K5"/>
    <dbReference type="OMA" id="ETLGFRN"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000194">
        <property type="entry name" value="AaceriADR145Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF17">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="57"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000181337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="904" mass="100966" checksum="2E09CBDF6F725179" modified="2005-04-26" version="1">MSSVHSKSFDGDLTSHRSVEYYDDSMNSSGSPFNFLAPSQVRGSTFIMDSNISTINNIKVICRFRPENEKELQKGKSIVEFPNTQTVTLYGKDYTTHYSFDRVFSPEASQLDIYQFSIAETVDDLINGYNGTVLAYGQTGSGKSYTMLGGPQLSDPNSKGIIPRISHEIFERISANEAVSSEVEYSVCVSFMEIHMEQIRDLIDVVNNEFDHKFTIHEDKSNGIYVKGLATRSVTNELELLNILSEGLKYRSISSTQMNEESSRSHTIFQVKLTQKHMETEVIKRSNLFLVDLAGSEKVDKTGAQGQTLEEAKKINSSLSALGNVINALTDGKSTHIPYRDSKLTRILQESIGGNSRTSLIINCSPSSFNELETLSTLRFGTRAKSIKNSAHVNTELSTASLKNRITQLEKMNQSNQSYIKQLEDELSSYRSEPHSSPSMFSMMRNSTATTTSIATSLATKPSNFQSRLPIPSTASIISSPPPSLARNSHMSDELDRRDKKIEELENVILNLKMQNLKTSHQEESKLFSLENSLQNITNKLNEVELVNINLRKHLLISEKIIESRDNKINKLKLSLKEQQLLISRETLGFRNRLGEIQMKLEDLNKYKEEEMSIKRETLLLQRQQSIGGVSSAGTGTGFGGGLDIMQRSGTTSTDDIQSISAFKPDPELIDNMYDDDRREVEEGNQPHHQYQQQQQQHQQQQEEHFDGGSHNHDGDDEQEEEGGEDHSNTLINRSSDSQISKNGSLRLANDIDKESLQEGFSIYSSKKLDDEYEGKPPQQPQQRLAASASFGNYKNGHNGILNFQQEYLSINEFLKESRRRSLMMANPATNFTPSTIPSPAQQPRVLSDVDSSDTSGMFGSGDAAGSMTPSSKSQKHRRNHSSSGGLNLKIVKPLKSAASLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4K5</accession>
    <name>Q5A4K5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C601480WA</name>
        <name evidence="5" type="ordered locus">orf19.10940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716743.1">
        <property type="nucleotide sequence ID" value="XM_711650.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4K5"/>
    <dbReference type="SMR" id="Q5A4K5"/>
    <dbReference type="STRING" id="237561.Q5A4K5"/>
    <dbReference type="GeneID" id="3641621"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601480WA"/>
    <dbReference type="CGD" id="CAL0000186367">
        <property type="gene designation" value="orf19.10940"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01480W_A"/>
    <dbReference type="HOGENOM" id="CLU_130497_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A4K5"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000186367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21201" checksum="86BE92D1C62641E3" modified="2005-04-26" version="1">MTIVTHPDFQIIKLTVSIVNDNNNITTTTNDGKNERNNNKPIEVPVKDAEKIHIVIPNGVQYQFTLYFQVKNKPYNNVRYKQVVKKHGITMRTRELEIGNYEPSPKIEKEGIKKEEEEQEEEQEEAEEEQVVTYSKEFPIDETPSSRFSRGFYYCTSWYYVGDDKNPIITTDWTLEIVAKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2025-06-18" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4P9</accession>
    <accession>A0A1D8PPR3</accession>
    <accession>O93990</accession>
    <name>DBP9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP9</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP9</name>
        <name type="ordered locus">CAALFM_C601890CA</name>
        <name type="ORF">Ca20C1.02</name>
        <name type="ORF">CaO19.10896</name>
        <name type="ORF">CaO19.3393</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AL033391">
        <property type="protein sequence ID" value="CAA21924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716703.2">
        <property type="nucleotide sequence ID" value="XM_711610.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4P9"/>
    <dbReference type="SMR" id="Q5A4P9"/>
    <dbReference type="FunCoup" id="Q5A4P9">
        <property type="interactions" value="1046"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4P9"/>
    <dbReference type="EnsemblFungi" id="C6_01890C_A-T">
        <property type="protein sequence ID" value="C6_01890C_A-T-p1"/>
        <property type="gene ID" value="C6_01890C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641598"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601890CA"/>
    <dbReference type="CGD" id="CAL0000180288">
        <property type="gene designation" value="orf19.10896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01890C_A"/>
    <dbReference type="HOGENOM" id="CLU_003041_17_1_1"/>
    <dbReference type="InParanoid" id="Q5A4P9"/>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="PRO" id="PR:Q5A4P9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232337" description="ATP-dependent RNA helicase DBP9">
        <location>
            <begin position="1"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="235"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21924." evidence="5" ref="1">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21924." evidence="5" ref="1">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="574" mass="65186" checksum="DFE1513342D3E826" modified="2017-03-15" version="2">MSTSASSSYLDDETTWDSFNLDPRLLQAIDQLGFSNPTLIQSSAIPLALEEKRDIIAKASTGSGKTAAYCIPIVNNLLTDDSSQGIKSIILVPTRELSNQVFQFVEKLLTFSTNKINVLNLSSSYSDQVLNSLLVNKPEIIISTPAKLIQILEKNEKNIDLSTVKNLTIDEVDLVLSFGYLDDLKKLESYLPVKKNLQTFLMSATVNDDLDDLKQRYCTKPAILKLNEDSANQNNLVQYYAKTTEFDKFLLAYVIFKLNLIKGKTIAFVNNIDRGYRLKLFLEQFGIRCCILNSELPINSRLHIVEEFNKNVYHLLIATDETNELNEEQDDDEDGDEDTKDKGNAETKPKKSKKSKFKQDKEYGVSRGVDFRNVACVLNFDLPTSSKAYIHRIGRTARAGKAGMALSFVLPLSEFGKHKTASLASAKKDEKVLGRIVKQQSKNGFEIKPYQFDMKQVEGFRYRADDAFRAVTQTAVREARVKELKNELINSEKLKRFFEENPQDLASLRHDKELHPARIQSQLKNVPQYLLPESARQDVKNIGFVPFHKNKIHKHRKGKGKGRKKVDPLKSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5R5</accession>
    <name>Q5A5R5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zsf1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">ZSF1</name>
        <name evidence="9" type="ordered locus">CAALFM_C210560CA</name>
        <name evidence="8" type="ordered locus">orf19.12794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717137.1">
        <property type="nucleotide sequence ID" value="XM_712044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5R5"/>
    <dbReference type="STRING" id="237561.Q5A5R5"/>
    <dbReference type="GeneID" id="3641257"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210560CA"/>
    <dbReference type="CGD" id="CAL0000194006">
        <property type="gene designation" value="ZSF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10560C_A"/>
    <dbReference type="eggNOG" id="KOG1677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084519_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A5R5"/>
    <dbReference type="OMA" id="CANWSKY"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061013">
        <property type="term" value="P:regulation of mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000018">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000194006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="203" mass="23319" checksum="C4ABAA058F547A35" modified="2005-04-26" version="1">MMSTLKDSKHFAFNGTKSSIASSSSSTTDFDDLLPDLWQTSSNESDIKHSSQSLFNSPHHYLFQQQPQQNWFNVSVSPANSVSSPLRSTSSLWEDPPAEQQQQQPQPIFYLPQDDDLFNFEQVHHPQHHTKTQINTQLYKTELCASFMKTGVCPYANKCQFAHGENELKHVERPPKWRSKPCANWTKYGSCRYGNRCCFKHGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6M0</accession>
    <accession>A0A1D8PSS8</accession>
    <name>RBR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Repressed By RIM101 protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Predicted GPI-anchored protein 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RBR1</name>
        <name type="synonym">PGA20</name>
        <name type="ordered locus">CAALFM_CR04440CA</name>
        <name type="ORF">CaO19.535</name>
        <name type="ORF">CaO19.8168</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="776" last="784">
            <title>RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1.</title>
            <authorList>
                <person name="Lotz H."/>
                <person name="Sohn K."/>
                <person name="Brunner H."/>
                <person name="Muhlschlegel F.A."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="15189998"/>
            <dbReference type="DOI" id="10.1128/EC.3.3.776-784.2004"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="5214" last="5225">
            <title>The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans.</title>
            <authorList>
                <person name="Alvarez F.J."/>
                <person name="Douglas L.M."/>
                <person name="Rosebrock A."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="18799621"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-05-0479"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probable cell wall protein required for filamentation at low pH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
            <topology evidence="7">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 6">Expressed under acidic conditions. Expression is positively regulated by HAP43 and NRG1, and repressed by RIM101. Expression is also controlled by SUR7.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717398.1">
        <property type="nucleotide sequence ID" value="XM_712305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6M0"/>
    <dbReference type="STRING" id="237561.Q5A6M0"/>
    <dbReference type="EnsemblFungi" id="CR_04440C_A-T">
        <property type="protein sequence ID" value="CR_04440C_A-T-p1"/>
        <property type="gene ID" value="CR_04440C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640986"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04440CA"/>
    <dbReference type="CGD" id="CAL0000198834">
        <property type="gene designation" value="RBR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04440C_A"/>
    <dbReference type="HOGENOM" id="CLU_169106_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A6M0"/>
    <dbReference type="OMA" id="MANIECE"/>
    <dbReference type="PHI-base" id="PHI:11395"/>
    <dbReference type="PRO" id="PR:Q5A6M0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001058">
        <property type="entry name" value="Synuclein"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01211">
        <property type="entry name" value="SYNUCLEIN"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424779" description="Repressed By RIM101 protein 1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424780" description="Removed in mature form" evidence="2">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15189998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18799621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="111" mass="9530" checksum="560553C2D581B960" modified="2005-04-26" version="1" precursor="true">MKFSTTLLALTASIAAVMSADSSAAASGAASAASGAKSGATSAASGAKSGASSVASAAKSGVSSAASAAKSGASSATGGSSAAKSGSSSGAGFAPVAGAGSLAAIAGLLLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-05" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6N8</accession>
    <accession>A0A1D8PSP3</accession>
    <name>RFT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RFT1</name>
        <name type="ordered locus">CAALFM_CR04280CA</name>
        <name type="ORF">CaO19.516</name>
        <name type="ORF">CaO19.8147</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </evidence>
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</entry>
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    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAR0</accession>
    <accession>A0A1D8PDV4</accession>
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        <recommendedName>
            <fullName>Transcription factor IWS1</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name type="ORF">CaO19.13630</name>
        <name type="ORF">CaO19.6252</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713747.2"/>
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    <dbReference type="STRING" id="237561.Q5AAR0"/>
    <dbReference type="EnsemblFungi" id="C1_06590C_A-T">
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        <property type="gene ID" value="C1_06590C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639514"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106590CA"/>
    <dbReference type="CGD" id="CAL0000188700">
        <property type="gene designation" value="orf19.13630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06590C_A"/>
    <dbReference type="eggNOG" id="KOG1793">
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000083355" description="Transcription factor IWS1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="2">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="400" mass="45797" checksum="93B9CDBEBB51E286" modified="2017-04-12" version="2">MSDPLADYTNLSHDEIDPSSANAAESEQAEPEQQVSEHYEPQPEELTYENDENVLNSIKVQKITDAEAIGEVVRKKVIRDSRPQGYQQDDFNDNSNVTLGSRPGHQQTDEIDISSMDPQQRKRFELEERMSAAIKPSNKRRRKADEDDLERMQDDKIDYLKDQMIKAANSDVEKNSQGQIATEKLKLLKEVSDILARADLAIPILDNNLLEAVRLWLEPLPDASMPAYQIQKELIHALETLPIKTDHLVASGIGKVLVFYQRSKRTEPSLKKIVDRLIGDWTRPILNKSDSYKDRTVQFHEYNRNKFTNKLSRGVKKREAKTLYEENAERRKRAAIPSTRTTAYKIAPQVDKSLLMRQQSRHASNDERFKRINSKLTSMSVKRKAAKKGGPSIEGRDLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD31</accession>
    <name>Q5AD31_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C200880WA</name>
        <name evidence="8" type="ordered locus">orf19.9584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719485.1">
        <property type="nucleotide sequence ID" value="XM_714392.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD31"/>
    <dbReference type="SMR" id="Q5AD31"/>
    <dbReference type="STRING" id="237561.Q5AD31"/>
    <dbReference type="GeneID" id="3638897"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200880WA"/>
    <dbReference type="CGD" id="CAL0000201942">
        <property type="gene designation" value="orf19.9584"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00880W_A"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="InParanoid" id="Q5AD31"/>
    <dbReference type="OMA" id="CTSSFRY"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="152"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000201942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="359" mass="40704" checksum="B312861142507A62" modified="2005-04-26" version="1">MTVITLNWGILGAGNISSQFVHDLVLNNQRDTQFHHIVKSIGCSSHDKGLDFIKKNNITLENNFQTTPIVESYEDFYKNSDIDVVYIGTPHTFHKEQSIACLNNNKHVLCEKPVTVNKAELESILNVAKSKKKFFMEAMWTRFFPAITELKKKIYDEKVIGEIHRLFADLSYNCDISNIPLSSRIRNKDLAAGSLLDIGIYPLTYSRVLLDDSLGENHSPFQIKSFLTIDSQDQVDHLYSAIVKYQNGKHAVLTASELIDGPKAYVRLEGSQGHVEMYSDNPARAKHFKIFNAKGDEIFEYKDGSGYNGFIYEANAVAKDITEGKLSNDTMPHDESLLIMETMDQIRHENGLVYPQDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADP3</accession>
    <name>Q5ADP3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">SSN6</name>
        <name evidence="12" type="ordered locus">CAALFM_C307020WA</name>
        <name evidence="11" type="ordered locus">orf19.14090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-10635830">
            <id>Q5ADP3</id>
        </interactant>
        <interactant intactId="EBI-10635759">
            <id>Q5ADP0</id>
            <label>RPD31</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719894.1">
        <property type="nucleotide sequence ID" value="XM_714801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADP3"/>
    <dbReference type="SMR" id="Q5ADP3"/>
    <dbReference type="FunCoup" id="Q5ADP3">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="IntAct" id="Q5ADP3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="MINT" id="Q5ADP3"/>
    <dbReference type="STRING" id="237561.Q5ADP3"/>
    <dbReference type="GeneID" id="3638518"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307020WA"/>
    <dbReference type="CGD" id="CAL0000174892">
        <property type="gene designation" value="SSN6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07020W_A"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006762_3_1_1"/>
    <dbReference type="InParanoid" id="Q5ADP3"/>
    <dbReference type="OMA" id="NPHHAKV"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0031490">
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</entry>
<entry dataset="Swiss-Prot" created="2013-05-01" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADT1</accession>
    <accession>A0A1D8PKQ3</accession>
    <name>MDS3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Negative regulator of sporulation MDS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MDS3</name>
        <name type="ordered locus">CAALFM_C307320WA</name>
        <name type="ORF">CaO19.14052/14051</name>
        <name type="ORF">CaO19.6760/6759</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Genetics" volume="162" first="1573" last="1581">
            <title>Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis.</title>
            <authorList>
                <person name="Davis D.A."/>
                <person name="Bruno V.M."/>
                <person name="Loza L."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="12524333"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Microbiology" volume="149" first="3629" last="3637">
            <title>Genetic control of chlamydospore formation in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Bruno V.M."/>
                <person name="Richard M.L."/>
                <person name="Davis D.A."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="14663094"/>
            <dbReference type="DOI" id="10.1099/mic.0.26640-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Microb. Pathog." volume="42" first="88" last="93">
            <title>Genetically regulated filamentation contributes to Candida albicans virulence during corneal infection.</title>
            <authorList>
                <person name="Jackson B.E."/>
                <person name="Wilhelmus K.R."/>
                <person name="Mitchell B.M."/>
            </authorList>
            <dbReference type="PubMed" id="17241762"/>
            <dbReference type="DOI" id="10.1016/j.micpath.2006.11.005"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>VIRULENCE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Eukaryot. Cell" volume="4" first="1493" last="1502">
            <title>Candida albicans biofilm-defective mutants.</title>
            <authorList>
                <person name="Richard M.L."/>
                <person name="Nobile C.J."/>
                <person name="Bruno V.M."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="16087754"/>
            <dbReference type="DOI" id="10.1128/EC.4.8.1493-1502.2005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2010" name="Mol. Cell. Biol." volume="30" first="3695" last="3710">
            <title>Mds3 regulates morphogenesis in Candida albicans through the TOR pathway.</title>
            <authorList>
                <person name="Zacchi L.F."/>
                <person name="Gomez-Raja J."/>
                <person name="Davis D.A."/>
            </authorList>
            <dbReference type="PubMed" id="20457806"/>
            <dbReference type="DOI" id="10.1128/MCB.01540-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH SIT4</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4 5 6 8">Negatively regulates early sporulation-specific genes (By similarity). TOR signaling pathway component that contributes to morphogenesis as a regulator of this key morphogenetic pathway. Required for growth and hyphal formation at pH 9, for full virulence in a mouse model of systemic infection and for biofilm formation. Involved in chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SIT4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Results in attenuated keratomycosis.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGC6</accession>
    <name>Q5AGC6_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Glucose-induced degradation complex subunit</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">CAALFM_C502450WA</name>
        <name evidence="2" type="ordered locus">orf19.11728</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715469.2"/>
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        <property type="gene designation" value="orf19.11728"/>
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    <dbReference type="eggNOG" id="KOG1477">
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
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            <begin position="145"/>
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            <begin position="286"/>
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            <begin position="417"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="599"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000195638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="781" mass="87945" checksum="8A08B95432D0B91A" modified="2005-04-26" version="1">MSDNSNSSGGSTIPSLCYVIPPYLLNSNYGSNLQKQLFAKNQQMGLLNVISTDSKNYYNHFKEQQQDQGEGNNKRKRKFTKDPYLNEIIKMKLIYKLSILGVLGDNPMEFLNGNDNDDYIYDMFDTFKRRLISSDDNDDDNGDSNSRDESKIGDGSDSGDVQLMLVDALRRNNKDDSNNYKLPKSVFSNGNNKIGEVEFNQLSGIPSQYKKYLSMSLKDLILSTNCHINDRYNYPPSFIDFGNDEFFNYTLPITWIPLIPNRYLSHLEKHYNLVIQDDQGFSNIKMSIDTSPNSASSSGAKNGDGSNLYQHDESHDDIAIDIDDEISRKQRQSRYYNLITDKAIISSVGIFYYEVEIEQVVTESTNFNSIIQMNDSSINSNNSMMLSLGFIKRLINFEPSPTTSPNSLHNHYHHDNNSGSNNNGNGNNNTGSILSGRVDLENIKSDLFANDSLEEEESIGDIETKKYLTARPGELRGSVAINLEDSILYNSINSISGEFGASSASASSSMHRAQILNMNRRLSNRSEYDSTATTTAGGGGVAGKINIDIPLKTKLVKDCRDERVYKTDIIGMGVNFIDKSIFITLNGVLARVITDTELNGNSDGDKTSNNNNNNSNNSNDNNNNKTSTTDNGKIDEEAMYPMIGFRINEINRSLNNVSDQKTNDKAKTTKVNIKTNFGSKSFFYDIDSYVAHYKNLTRQLLNMKILEMINLDVKEYNAAQQEIDKSNVFEIIKNYMMSNGGVNNHNNNNIFANLQRNLLELNEKDNKDHLFTLINLENDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH10</accession>
    <accession>Q3MPF0</accession>
    <name>Q5AH10_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C701930CA</name>
        <name evidence="2" type="ordered locus">orf19.13881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000018">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
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    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="30"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="154"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="293"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="515"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0000183638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AOW28234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="709" mass="78963" checksum="FC53942EE78460D4" modified="2005-04-26" version="1">MSFTKKNVSLAEGPDPRSSIQTERANSKFNPEQMNYFLEGSKERSELFKGLAQQMERDPVLFTDGSYYDLTKDQQRELTALKINRLARYRETDSIDTFNKRLSLVGVFDPQVGTRIGVNLGLFLSCIRGNGTAEQLKYWAFDKETSNIKGIYGCFGMTELAHGSNVAGLETTATFDKETDEFVINTPHIGATKWWIGGAAHSATHCSVYARLIVDGEDYGVKTFVVPLRDSNHDLMPGVTVGDIGAKMGRDGIDNGWIQFSNVRIPRFFMLQKFCKVSADGDVVLPPLEQLSYSALLGGRVMMVLDSYRMLARMSTIALRYAIGRRQFKGDNVDQNDPNALETQLIDYPLHQKRLFPYLAAAYVISASALKIEHTIETTLEELDQAVAKEDQRAIFKSIDDMKSLFVDSGSLKSTATWLAAEAIDQCRQACGGHGYSSYNGFGKAYNDWVVQCTWEGDNNVLGMSVGKPIVREIINLEDKDKKVRGSTAFLNQLKEYTGSNSSKVVLDNVADLDDINKVIKAIEVAIIRLGQEAASTVRKESLDFVGAELVQLSKLKAHHYSLSEYVRRVNEFDQKELVPYLLTIAKLYGATVVLDKFAGIFLTFNVASTKAITDLASIQIPKLCAEVRPNVVAYTDSFQQSDMIVNAAIGKYDGDIYENYFDLVKAQNPPSKTKAPYSAALEAMLNRPSLEARERFEKTDETAEILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALV9</accession>
    <name>Q5ALV9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">COX13</name>
        <name evidence="14" type="ordered locus">CAALFM_C201590WA</name>
        <name evidence="13" type="ordered locus">orf19.9042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722517.1">
        <property type="nucleotide sequence ID" value="XM_717424.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALV9"/>
    <dbReference type="SMR" id="Q5ALV9"/>
    <dbReference type="FunCoup" id="Q5ALV9">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALV9"/>
    <dbReference type="GeneID" id="3635784"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201590WA"/>
    <dbReference type="CGD" id="CAL0000194951">
        <property type="gene designation" value="COX13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01590W_A"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ALV9"/>
    <dbReference type="OMA" id="KLPWMVD"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00925">
        <property type="entry name" value="Cyt_c_Oxidase_VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000194951"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW27205.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="134" mass="15892" checksum="351A5ED9BE1E07FD" modified="2005-04-26" version="1">MFKAVQQLTFRRFNSHHLQPSKLLNELAYKPNKQVGEEFIKKYEEKVHHSEGITNLWKRLTYLVAIPAVLLVAIPVGKVELSHAEHRKHQAHLSDDEWPQQYDYQNIRSKPYFWGDGDKTLFWNSDVNRHVVKD</sequence>
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<entry dataset="Swiss-Prot" created="2013-12-11" modified="2025-04-09" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMQ6</accession>
    <accession>A0A1D8PLF4</accession>
    <name>RFX2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>RFX-like DNA-binding protein RFX2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RFX2</name>
        <name type="ordered locus">CAALFM_C402030WA</name>
        <name type="ORF">CaO19.12059</name>
        <name type="ORF">CaO19.4590</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="EMBO J." volume="20" first="4742" last="4752">
            <title>NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans.</title>
            <authorList>
                <person name="Murad A.M."/>
                <person name="Leng P."/>
                <person name="Straffon M."/>
                <person name="Wishart J."/>
                <person name="Macaskill S."/>
                <person name="MacCallum D."/>
                <person name="Schnell N."/>
                <person name="Talibi D."/>
                <person name="Marechal D."/>
                <person name="Tekaia F."/>
                <person name="d'Enfert C."/>
                <person name="Gaillardin C."/>
                <person name="Odds F.C."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="11532938"/>
            <dbReference type="DOI" id="10.1093/emboj/20.17.4742"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="2251" last="2266">
            <title>The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicans.</title>
            <authorList>
                <person name="Goyard S."/>
                <person name="Knechtle P."/>
                <person name="Chauvel M."/>
                <person name="Mallet A."/>
                <person name="Prevost M.C."/>
                <person name="Proux C."/>
                <person name="Coppee J.Y."/>
                <person name="Schwartz P."/>
                <person name="Dromer F."/>
                <person name="Park H."/>
                <person name="Filler S.G."/>
                <person name="Janbon G."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="18321992"/>
            <dbReference type="DOI" id="10.1091/mbc.E07-09-0960"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="PLoS Genet." volume="6" first="E1001070" last="E1001070">
            <title>The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation.</title>
            <authorList>
                <person name="Tuch B.B."/>
                <person name="Mitrovich Q.M."/>
                <person name="Homann O.R."/>
                <person name="Hernday A.D."/>
                <person name="Monighetti C.K."/>
                <person name="De La Vega F.M."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="20808890"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1001070"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="627" last="639">
            <title>Candida albicans RFX2 encodes a DNA binding protein involved in DNA damage responses, morphogenesis, and virulence.</title>
            <authorList>
                <person name="Hao B."/>
                <person name="Clancy C.J."/>
                <person name="Cheng S."/>
                <person name="Raman S.B."/>
                <person name="Iczkowski K.A."/>
                <person name="Nguyen M.H."/>
            </authorList>
            <dbReference type="PubMed" id="19252121"/>
            <dbReference type="DOI" id="10.1128/EC.00246-08"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1498" last="1510">
            <title>Transcriptional responses of candida albicans to epithelial and endothelial cells.</title>
            <authorList>
                <person name="Park H."/>
                <person name="Liu Y."/>
                <person name="Solis N."/>
                <person name="Spotkov J."/>
                <person name="Hamaker J."/>
                <person name="Blankenship J.R."/>
                <person name="Yeaman M.R."/>
                <person name="Mitchell A.P."/>
                <person name="Liu H."/>
                <person name="Filler S.G."/>
            </authorList>
            <dbReference type="PubMed" id="19700637"/>
            <dbReference type="DOI" id="10.1128/EC.00165-09"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="384" last="397">
            <title>G1/S transcription factor orthologues Swi4p and Swi6p are important but not essential for cell proliferation and influence hyphal development in the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Hussein B."/>
                <person name="Huang H."/>
                <person name="Glory A."/>
                <person name="Osmani A."/>
                <person name="Kaminskyj S."/>
                <person name="Nantel A."/>
                <person name="Bachewich C."/>
            </authorList>
            <dbReference type="PubMed" id="21257795"/>
            <dbReference type="DOI" id="10.1128/EC.00278-10"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional repressor which regulates DNA damage responses, morphogenesis, and virulence. Involved in the regulation of filamentous growth through its repression of hyphal-specific genes such as HWP1, ALS3, HYR1, ECE1, and CEK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 6 7 8">Expression is negatively regulated by NRG1, and by the contact with host oral epithelial cells. Up-regulated during the yeast-to-hypha transition through the function of YAK1. Also regulated by SWI4, SWI6, and WOR1, a transcriptional regulator of white-opaque switching.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to increased resistance to UV-killing, derepression of various stress-related genes, hyperfilamentous growth, and overexpression of hypha-specific genes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RFX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_717569.2"/>
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    <dbReference type="STRING" id="237561.Q5AMQ6"/>
    <dbReference type="EnsemblFungi" id="C4_02030W_A-T">
        <property type="protein sequence ID" value="C4_02030W_A-T-p1"/>
        <property type="gene ID" value="C4_02030W_A"/>
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    <dbReference type="GeneID" id="3635658"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402030WA"/>
    <dbReference type="CGD" id="CAL0000192725">
        <property type="gene designation" value="RFX2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C4_02030W_A"/>
    <dbReference type="HOGENOM" id="CLU_009415_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AMQ6"/>
    <dbReference type="OMA" id="YPILMYN"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001217">
        <property type="term" value="F:DNA-binding transcription repressor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="project" value="CGD"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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        <property type="entry name" value="RFX_DBD"/>
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    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
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        <location>
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        </location>
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    <feature type="DNA-binding region" description="RFX-type winged-helix" evidence="1">
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            <end position="540"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1050"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        <source>
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        <source>
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    </evidence>
    <sequence length="1111" mass="125295" checksum="D8F4753347466F65" modified="2017-05-10" version="2">MSNNPHRTHKRQKSSVSNPGYYFTPETKSEIQQQQPQQQESQQQQQQQQQQHSQTHNIYDNDNYMNYNFPPTSNRPRASTTTGTTSTTHPGSELSHESHSVHTSPLKRTASSELDQPIPAMAPSSPLVSSAPYYYQQPSQQQNLSYHDHHHQQQQQQSTPQGQQLSQQTQSNSQSGVPPPLYGTSSSIPPGSTMQPSTSFAFHTSHSTYNPSFDSSNLYNSAFRLPEYPTTSSSSLLSTTGGKQFQQSSALLPSGTLPPSILGTSSSSHVSALRQHQKNNLSISSHLTLFSLSGNNSSQLQSQGSSFQQSETGVDDTKRSSKESTTIFNDLLFHLTSVDGSNINTFLLSILRKINSPFTLDDFYNLLYNDRQRTLLDNSNYQNRIDKTIVSPSDTDMTVSIINQLLNFFKTPSMLVDYFPNMEDKDNKLANINYHELLRTFLAIKILHDILIQLPISEDDDPQNYTIPRLSIYKTYYIICQKLIASYPSASNTRNEQQKLILGQSKLGKLIKLVYPNLLIKRLGSRGESKYNYLGVMWNANIVQEEIKQLCDEHELNDLNEIFNSDNNNPFASIAPSGSATTGSTPRRGLSHKRTSSKQKIKTEPVAGNPFLQPLQTSHHHHHSHHHHHEEQSQEESLSQQMGEHITAPRLSFLRANSKYPTDVNLSVLDDDNWFVRLSYECYARQPALNRDLIQQIFLKNEFLLNNSSLLQNLMDSIIKPLVMQETYSNVDLVLYLAILLEILPYLLLVKSSTNINLLKNLRLNLLHLINNFNNELKKLDSPKFPIERSTIFLVLVKKLINLNDLLITFIKLINRDNCKTTMSSDIENFLKINSQTVKLDDDDNSFFFNLNTTSMGEVNFNFKNEILSNDLIYTLIGYNFDPTTNSELKSSISMNFINEEINVIDEFFKNDLLNFLSTDFHAGLDDDNGEEDDDEEAGPGSTHPMGATGSQGSLSPEPVSTGNPSVPPTRNTSISEVNAENKRGNEAVLTPKETAKLNSLISLIDKRLLSSQFKSKYPILMYNNCISYILNDILKHIFLKQQQQQLQSSSSQLHDTQPLTQQDTAQGIGSSSSNANNTNSSFGNWWVFNSFIQEYMSLIGELVGLHDNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANC7</accession>
    <name>Q5ANC7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C305060WA</name>
        <name evidence="2" type="ordered locus">orf19.13397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723187.1">
        <property type="nucleotide sequence ID" value="XM_718094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANC7"/>
    <dbReference type="SMR" id="Q5ANC7"/>
    <dbReference type="STRING" id="237561.Q5ANC7"/>
    <dbReference type="GeneID" id="3635241"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305060WA"/>
    <dbReference type="CGD" id="CAL0000181321">
        <property type="gene designation" value="orf19.13397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05060W_A"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049045_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ANC7"/>
    <dbReference type="OMA" id="DHIVRDD"/>
    <dbReference type="OrthoDB" id="4023202at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000181321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="52031" checksum="261BE0C017343973" modified="2005-04-26" version="1">MKPLFTYKIPDSPHWYIVITDTSHHFYFNNHDKSSYWQLSDIQEHYKNDIDIVKRLIKSINFDELAILFAKSRGVKFEKIEDELESIEVDHSKEEVQPKQTEQQQVTEEEEIVVVENIPSKVTKAKPKEEKQPSTKQINSIIQGYLSSDDEEDEEEEVNSKETKQESSQTINIDELTSQALAQHQKSTEIESDDDDDNDNGSLDLSLSETEDAATASTSSAEQDFINLLNQFSNRISIYESWDLVEEELLPEFTTYPEFFAISSKSERQKLFQKWCTQQEPKSPQTTINEGAFPTVKLNYLIFLQDFKQDIKQSFYQSFYNSHYQKLNEFNLSSQMKETIFRNYKIMLNDFTKFAKNYKKSNVGDNRNLKVMKLNEFLQNKLHSHITNTADSGPFSVDSNLSDLDNWINLLNHYDIPTDIAENEINFLVGDEKRLNSYIDQLKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANI8</accession>
    <name>Q5ANI8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding ribosome biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">MAK21</name>
        <name evidence="5" type="ordered locus">CAALFM_C304560WA</name>
        <name evidence="4" type="ordered locus">orf19.13333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723125.1">
        <property type="nucleotide sequence ID" value="XM_718032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANI8"/>
    <dbReference type="SMR" id="Q5ANI8"/>
    <dbReference type="FunCoup" id="Q5ANI8">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANI8"/>
    <dbReference type="GeneID" id="3635147"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304560WA"/>
    <dbReference type="CGD" id="CAL0000182474">
        <property type="gene designation" value="MAK21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04560W_A"/>
    <dbReference type="eggNOG" id="KOG2038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ANI8"/>
    <dbReference type="OMA" id="EIWCNDE"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="609"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000182474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1066" mass="121699" checksum="AAD65A7E45F53EB1" modified="2005-04-26" version="1">MSSGLNLSSLKDKIFSKLNLQKDNQTKSQQKSKKASSNDKEIQKDKKKPATPAKANAKKTKGVDEILRREALALGATDEDLKLVEGIESDDDKSEQEFDDDSKLDKNFSADLSKFMKGIGLGEEEAMVVSEEEEEEAMVVSEEEEEEVPELVEGEEEEEEKVSEDDVVEEEEESISEKESESEDTSDSESEKEVVVKEAKIDNKKSNQDPDKVTDLSSVSSSKLIVPNRTDWFNIVEVPAETPEKLDRFARERLLERAQKTIEKDNKTYLEEFASNTSQKKFLSQILSDGTLNDKISALTLLIQEAPLHNLKALDTLLAYCDKKSRTAALQSIVALKDLFVNSLLPDRKLFAFDKQPLRKDDSDIQLAIYYFEDHLKKVYFKLIQILEKLSHDPIVHVRMTVVNHIFDLLGAKPEQEVNLLKLGVNKLGDIDNKVSAKASYLILQLEQAHPAMKQIITDAVIDVIFQSNNDDHAKYYGVTTLNQTILTRKEHELANSLVKTYFALFEKILVESDGYNKDTKDDKSIGDSKKGRKNNRKNFKKGKKGGKSVKIEEKTEQELVEEKNAKFFSALLTGLNRAFPFSKLPNEIFQSHLDTLFKITHSSNFNTSIQALVLINHIVSEQGLNSDRYYRTLYESLLDPRLANSSKQGIYLNLLFKSLKNDIANIPRVLAFVKRMLQICSHWLNVGAVAGMLYLMMELSKTIPEISDLLVEFASRPDDTEESSEKDTEEVDKTKDENKDIEYDPRKRNPKFANANRSSLWEIHQFLNHYHPTIAIYASSFLDGTEQVKPDLGLYTLSHFLDRFVYKNAKQKPQTKGSSIMQPLGGAHTGSLLVRSTNLVDTTVPVNTENWLGKKIEDIKPDEKFFHQYFSTKVNKLKTKKDDKKSKEEGDNDDDEEDDNEMDDDEVWKALVKSRPEVEDASEDDFSDFDEEDFADMDSEEENEEDANEEKEDVEGEFSDAKLEAELDGDDDEELDQDDFDDDEKAMFAINDEDEFEDDEIELKMLGDDDDDEEEESEEEEEETKKRARENDSHSKKKSKKQRVKDLPIFASAEDYAEYLDSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANL4</accession>
    <name>Q5ANL4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">NUP85</name>
        <name evidence="12" type="ordered locus">CAALFM_C304400CA</name>
        <name evidence="11" type="ordered locus">orf19.13308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723103.1">
        <property type="nucleotide sequence ID" value="XM_718010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANL4"/>
    <dbReference type="SMR" id="Q5ANL4"/>
    <dbReference type="FunCoup" id="Q5ANL4">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANL4"/>
    <dbReference type="GeneID" id="3635175"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304400CA"/>
    <dbReference type="CGD" id="CAL0000195620">
        <property type="gene designation" value="NUP85"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04400C_A"/>
    <dbReference type="eggNOG" id="KOG2271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019986_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ANL4"/>
    <dbReference type="OMA" id="VKHYSWM"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036177">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000195620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="773" mass="89690" checksum="2474E2914855858D" modified="2005-04-26" version="1">MPEYTNFESKFDDIDMLEIPEDDDGENSIDNSISSETEGISDSSDSSKSSYDQWSPVAIFKSDKEYIDLSDWLNTQKSLEFKFDVQKYRKGIEKSRPFDEKYILYVNNMFKIIQKLTEDDITRFDLEEDDSPIGLVMDSMGSKAKQVRKFKKIDEALREIIDYLQDLVNSIPKEEQESYDSQCLQHVLYILECFEANNFYFDIQQKPELIIKWVNTFDPKPDPELLNDVIVNTPQPYLHPRFWNTCISQLLTRGLFTQIHEVIEHSQYQELKEKCPELYAVIGDMDTLLSNYTSYSSKGQFTAWKLLACEFRDSLSSVRNESITETKHKLIIDQIYDLACIFTGLPKTISSYCDTWYEVYLALSLYQVRDSNEVYIDYFKTAVSEKPPSDIFDDENENLDGLTEACFLNILENNFLKVLETLHELDPPTTAYLAELMELRFLLRGYYFDVTVTSSASFEDLLNRRIVSEYFLTRHAYDCLNIHELVPVGIGLLLNNVVCTSNNAVSANRKVIATFLPNYICNTNDDLEWALTICANLNLVSTARQLYYQAGLKSLEEGYMYEALNNFVNCYDPTLLSGENHSEGMKKVHYIVWDLIFANCLVHNRPIKDELINNIVDKKVDLNFKIHPVIQQCLAPYAVLKEFYETLPQRDIKLSNKLSKLIHLLKFNYLPKKFVPLLLAQFIPFLSEPNTTFQLPDLVIIIELLDNYESDRNEKELKEGADLYLYSINNIESDADENDWRKLVGKDNLPKDIDSFTRLLRNLIAAKVGKVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AP71</accession>
    <name>Q5AP71_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">TPK1</name>
        <name evidence="16" type="ordered locus">CAALFM_C110220CA</name>
        <name evidence="15" type="ordered locus">orf19.12357</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723574.1">
        <property type="nucleotide sequence ID" value="XM_718481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AP71"/>
    <dbReference type="SMR" id="Q5AP71"/>
    <dbReference type="STRING" id="237561.Q5AP71"/>
    <dbReference type="GeneID" id="3634879"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110220CA"/>
    <dbReference type="CGD" id="CAL0000200060">
        <property type="gene designation" value="TPK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10220C_A"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="Q5AP71"/>
    <dbReference type="OMA" id="KHTVVKL"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PHI-base" id="PHI:427"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:cell morphogenesis"/>
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        <property type="term" value="P:cellular response to stress"/>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="term" value="P:filamentous growth of a unicellular organism"/>
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        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan metabolic process"/>
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        <property type="term" value="P:hyphal growth"/>
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        <property type="term" value="P:negative regulation of cell adhesion involved in single-species biofilm formation"/>
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        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
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        <property type="term" value="P:regulation of single-species biofilm formation on inanimate substrate"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="AGC-kinase_C"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="93"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000200060"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="405" mass="46722" checksum="A415F092327E9AA6" modified="2005-04-26" version="1">MTSMEPADTSIRSLNDINLQELANKQHQRNIYAQGSPTLEDSITSNGNDINNPNNNINKTNNNSNSSLSLTKKTSRHINKDTTTKGKYTLNDFQILRTLGTGSFGRVHLTRSIHNGRFYAMKVLKKQRVVQMKQIEHTNDERRMLKLAQHPFIIRMWGTFQDCHNLFMIMDYIEGGELFSLLRKSQRFPTPVAKFYAAEVFLAIEYLHSLDIIYRDLKPENILLDKNGHIKLTDFGFAKEVQDVTYTLCGTPDYIAPEVVATKPYNKSVDWWSFGILIFEMLTGYTPFYDPTPMKTYENILNGSITYPDYLPPDILDLLQKLIVKDLTQRLGNLQGGSDDVKNHPWFKEVIWERLLSRDIETPYEPPITSGVGDTSQFDRYPEDKDLDYGISGVEDPYRDQFQDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AP97</accession>
    <accession>A0A1D8PER4</accession>
    <name>SWE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitosis inhibitor protein kinase SWE1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Wee1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SWE1</name>
        <name type="ordered locus">CAALFM_C110010CA</name>
        <name type="ORF">CaO19.12331</name>
        <name type="ORF">CaO19.4867</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="J. Cell Biol." volume="164" first="581" last="591">
            <title>In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organization.</title>
            <authorList>
                <person name="Wightman R."/>
                <person name="Bates S."/>
                <person name="Amornrrattanapan P."/>
                <person name="Sudbery P."/>
            </authorList>
            <dbReference type="PubMed" id="14769857"/>
            <dbReference type="DOI" id="10.1083/jcb.200307176"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="55" first="381" last="395">
            <title>Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence.</title>
            <authorList>
                <person name="Umeyama T."/>
                <person name="Kaneko A."/>
                <person name="Nagai Y."/>
                <person name="Hanaoka N."/>
                <person name="Tanabe K."/>
                <person name="Takano Y."/>
                <person name="Niimi M."/>
                <person name="Uehara Y."/>
            </authorList>
            <dbReference type="PubMed" id="15659158"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04405.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="59" first="1452" last="1472">
            <title>Rad52 depletion in Candida albicans triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes.</title>
            <authorList>
                <person name="Andaluz E."/>
                <person name="Ciudad T."/>
                <person name="Gomez-Raja J."/>
                <person name="Calderone R."/>
                <person name="Larriba G."/>
            </authorList>
            <dbReference type="PubMed" id="16468988"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.05038.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Mol. Biol. Cell" volume="18" first="265" last="281">
            <title>Regulation of Cdc42 GTPase activity in the formation of hyphae in Candida albicans.</title>
            <authorList>
                <person name="Court H."/>
                <person name="Sudbery P."/>
            </authorList>
            <dbReference type="PubMed" id="17093060"/>
            <dbReference type="DOI" id="10.1091/mbc.E06-05-0411"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Microbiology" volume="155" first="3847" last="3859">
            <title>SLA2 mutations cause SWE1-mediated cell cycle phenotypes in Candida albicans and Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Gale C.A."/>
                <person name="Leonard M.D."/>
                <person name="Finley K.R."/>
                <person name="Christensen L."/>
                <person name="McClellan M."/>
                <person name="Abbey D."/>
                <person name="Kurischko C."/>
                <person name="Bensen E."/>
                <person name="Tzafrir I."/>
                <person name="Kauffman S."/>
                <person name="Becker J."/>
                <person name="Berman J."/>
            </authorList>
            <dbReference type="PubMed" id="19778960"/>
            <dbReference type="DOI" id="10.1099/mic.0.033233-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1000752" last="E1000752">
            <title>An extensive circuitry for cell wall regulation in Candida albicans.</title>
            <authorList>
                <person name="Blankenship J.R."/>
                <person name="Fanning S."/>
                <person name="Hamaker J.J."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="20140194"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000752"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7 8 9">Protein kinase that acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylating and inhibiting the mitosis-promoting cyclin B-bound CDC28 at 'Tyr-18'. SWE1-mediated inhibition of CDC28 acts in a cell size or morphogenesis checkpoint to delay mitosis in response to defects in growth, actin organization or bud formation. Plays an important role in filamentous growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylated.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="10">Leads to hypersensitivity to caspofungin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723552.2">
        <property type="nucleotide sequence ID" value="XM_718459.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AP97"/>
    <dbReference type="SMR" id="Q5AP97"/>
    <dbReference type="FunCoup" id="Q5AP97">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AP97"/>
    <dbReference type="EnsemblFungi" id="C1_10010C_A-T">
        <property type="protein sequence ID" value="C1_10010C_A-T-p1"/>
        <property type="gene ID" value="C1_10010C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634866"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110010CA"/>
    <dbReference type="CGD" id="CAL0000197159">
        <property type="gene designation" value="SWE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10010C_A"/>
    <dbReference type="eggNOG" id="KOG0601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009087_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AP97"/>
    <dbReference type="OMA" id="KMFKNAN"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="PRO" id="PR:Q5AP97"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000424371" description="Mitosis inhibitor protein kinase SWE1">
        <location>
            <begin position="1"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="791"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="929"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="797"/>
            <end position="805"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="934"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="947"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="14769857"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="PubMed" id="17093060"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="20140194"/>
        </source>
    </evidence>
    <sequence length="1178" mass="130733" checksum="F9662B10E7805023" modified="2017-05-10" version="2">MDSNPCQDVSGDTSSTPMANNNPTNDSTISSQNHSKIGLRKHQQQHYHQHSHSQMHSHSQQSPYINQLEYFTNNQFSRSFNSLILEDANDANTNNSSTTTLNKKTINKSPPFNIKQDLLNDSIDTFLDNSNTETIEDGDVTTTDDDHDFDDEDIEDPEAVQYTPTLNILKSKKVDSFDIISSKHRKSNSQITYNSHVRKPSEEDTSSSMATIRLSNNSQSSIKRSSKYLNLSIDSNLKTVDGGKIPDEIDDISLNEIDVAVAPNDFSSPLSARKPDIFAAITAANGNSNNQFKRPHKLVSQSPSPSSKNKFRISSSTTSSPQSNLHSPSKLGSKGFKMFKNANRDAIMSSSRVMTPEKPKMVSKIFGKSAKIRRAYTPTHTSTPMAVSSLNPPSSSTSNSTTAAITSTSPPANEHYDIDNDFDSPSKNRKSSNISASSIIIYQDENHIKSNHARKSSNPIPYPPTEPLPTNISASVAETGKGSTTTKSNLSKGCPLFDDKENKASYQFVKPLQTAFNSSGLVKKNSISGSSDRKLPPETPIKRNPLMILNTNKVVPPYSSGFAEGKDVMGDQHDIYSHIPCQNQRFPGSVNPNTTTNNNNTQQHHDSDLSIEVGRNNSYDASSSTINNTSYIKIFPSSELKKEQVLQRPQEDLELVFNSDIELDDNIIPETPTKKSLLPNQHHQHHLPLYTQSKSPLLKFDTEKDGRRNLSIVLDKSNATKREISEPPSTPINMSFAKNSFKKPMNNAERGDDPDSIIAQRIDIMPSLDEADSVSVYPSKIDEHLIEKFGMKNIKYIGSGAFSIAFECLFNNEKFAIKRTKKPLIGKLEKQTIKREIEALRVLTSIKEDEATNMQEQEEGKEYLVYFIEAWDFNNYYYIMTEFCEGGTLFDFLEENKHYKIDEFRIWKILIEILNGLKFIHSKNYLHLDLKPANIFITFEGSLKIGDFGLATKLPILEKDFDLEGDRNYIAPELINDKIYTPFADIFSLGLIILEIAANIILPDNGTPWRKLRSGDLSDAGRLSSDNISMFLQHNPNTNSNISGSGSRSGSGSTGGNGSAGDGSTNSTNFSYNSLSGNSLTLNPPVKAVHGTSDTNNTLASELSKNIEGLIPSWAPDFLVHGDSMNLDKLVNKMLRPNPFDRPSACNILEMPECLIVENRRKCGATIFEGEFGSPPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCP6</accession>
    <name>A0A1D8PCP6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Age3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">AGE3</name>
        <name evidence="9" type="ordered locus">CAALFM_C102260CA</name>
        <name evidence="8" type="ordered locus">orf19.11167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713777.2">
        <property type="nucleotide sequence ID" value="XM_708684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCP6"/>
    <dbReference type="SMR" id="A0A1D8PCP6"/>
    <dbReference type="FunCoup" id="A0A1D8PCP6">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCP6"/>
    <dbReference type="GeneID" id="3644565"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102260CA"/>
    <dbReference type="CGD" id="CAL0000194066">
        <property type="gene designation" value="AGE3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02260C_A"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCP6"/>
    <dbReference type="OMA" id="MSKLWEV"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
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        <property type="term" value="P:filamentous growth"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
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        <property type="entry name" value="Arf GTPase activating protein"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
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        <property type="entry name" value="ArfGAP_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
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    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="229"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="330"/>
            <end position="341"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
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        <source>
            <dbReference type="CGD" id="CAL0000194066"/>
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        <source>
            <dbReference type="EMBL" id="AOW25911.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="379" mass="41903" checksum="4CCD79746B81D62A" modified="2017-01-18" version="1">MSIDPETRRKLLNLQKTGENKKCFDCSAPNPQWASPKFGIFICLECAGVHRGLGVHISFVRSITMDQFKPEETLRMEIGGNERLKKYFIDNGVDLNLSPKQKYDNYVAEDYKEMLTCEVEGKEFVAKDHSGEKLPDINNTASTTTDPVSRGRPTPVPLTNEQKQKNEAYFADLGAKNDQRPDHLPPSQGGKYGGFGNTPAPSNTTSNNNNNNNSNNNNNNNNNNSSLSSFTLDNFQNDPLGTFTKGWGLFSSTVVKSVQEVNNSVIKPSIDQIQSSKITGQAKTAMAQFGQKMQQTGKYGQETFQTFTKDINENGLNKTLDSTFGGIFGHNNNNNGSNQGNQVPNAFGFKKPDNGVKYESLSGGSKKNDDDDDDKWDDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCX8</accession>
    <name>RL6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPL6</name>
        <name type="ordered locus">orf19.3003.1</name>
        <name type="ORF">CAALFM_C103110WA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019475079.1"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
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    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
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    <dbReference type="PDB" id="7Q0F">
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        <property type="resolution" value="2.64 A"/>
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        <property type="resolution" value="2.77 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
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        <property type="resolution" value="2.90 A"/>
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    <dbReference type="EMDB" id="EMD-13737"/>
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    <dbReference type="EMDB" id="EMD-50957"/>
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    </dbReference>
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    <dbReference type="EnsemblFungi" id="C1_03110W_A-T">
        <property type="protein sequence ID" value="C1_03110W_A-T-p1"/>
        <property type="gene ID" value="C1_03110W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30514975"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103110WA"/>
    <dbReference type="CGD" id="CAL0000181737">
        <property type="gene designation" value="RPL6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03110W_A"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCX8"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rib_uL2_dom2"/>
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        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
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            <begin position="1"/>
            <end position="176"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000305" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW25992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="176" mass="19763" checksum="0CFFA028E3296983" modified="2017-01-18" version="1">MSQVAPKWYQSEDVPAPKQTRKTARPQKLRASLVPGTVLILLAGRFRGKRVVYLKNLEDNTLLVSGPFKVNGVPLRRVNARYVIATSTKVNVSGVDVSKFNVEYFAREKSSKSKKSEAEFFNESQPKKEIKAERVADQKSVDAALLSEIKKTPLLKQYLAASFSLKNGDRPHLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCX9</accession>
    <name>A0A1D8PCX9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">TEM1</name>
        <name evidence="7" type="ordered locus">CAALFM_C103080CA</name>
        <name evidence="6" type="ordered locus">orf19.10519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330622.1">
        <property type="nucleotide sequence ID" value="XM_019475077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCX9"/>
    <dbReference type="SMR" id="A0A1D8PCX9"/>
    <dbReference type="FunCoup" id="A0A1D8PCX9">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCX9"/>
    <dbReference type="GeneID" id="3636923"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103080CA"/>
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        <property type="gene designation" value="TEM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03080C_A"/>
    <dbReference type="eggNOG" id="KOG1673">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCX9"/>
    <dbReference type="OMA" id="FDLNCTI"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of protein localization to nucleolus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of mitotic division septum assembly"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000197426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW25989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="200" mass="22835" checksum="F91C2796467539B3" modified="2017-01-18" version="1">MEEDNQQDQNNQVALKIGLIGDSQIGKTSLMVKYVEGSFDEDYIQTLGVNFMDKKIQIRNTTITFSIWDLGGQKEFINMLPLVSNDAVAILFMFDLTRKSTLNSIKEWYRQVRGFNKTAIPFLVGTKYDQFIDLSFQDQIEITQQAKKFGSAMKAPVIFCSTSHSINVQKIFKIILSKAFDLKLNLDEIVNVGEPILIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDJ8</accession>
    <name>A0A1D8PDJ8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C105380CA</name>
        <name evidence="10" type="ordered locus">orf19.8057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715862.2">
        <property type="nucleotide sequence ID" value="XM_710769.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDJ8"/>
    <dbReference type="SMR" id="A0A1D8PDJ8"/>
    <dbReference type="STRING" id="237561.A0A1D8PDJ8"/>
    <dbReference type="GeneID" id="3642480"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105380CA"/>
    <dbReference type="CGD" id="CAL0000184448">
        <property type="gene designation" value="orf19.8057"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05380C_A"/>
    <dbReference type="eggNOG" id="ENOG502QPT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDJ8"/>
    <dbReference type="OrthoDB" id="4070686at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14267">
        <property type="entry name" value="Rif1_CTD_C-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="9">
        <location>
            <begin position="395"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1366"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1543"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1405"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1543"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1561"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000184448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1665" mass="188616" checksum="C63AFF86D0810759" modified="2017-01-18" version="1">MQNICRKQYLVVESVYMLPNARRASFEFFLFAQKKNYSPISKPFLLGTRSSRIFTHGSKTTSTVFEEKKSTYRYQQLIFLFLLGFLDFVKNCNSLFFLYANEELNYLRSLNMPPKRKKLSKETKLASLSKKQSPIVTTRRRRSARKLSHENKNSPSRTQKIEDDIGVDTQMSEEIASSLNSSPIKQIDRRSNNSTPTKNTLSSSPIKTKKSVAFSDDLISDIPSTPDRNHSSGRSILKSCNSEFQNRLVDPSNTSLWRKANENVSYGPKNPDFWLQGTIVQLPPNSPDLYHLIEGCITVLQDASFDKRFEVYATLNGVYKTNSGSGAVKLFSSTLEDSVLASPRKNRSTPSPLKNNSPTKKQRESSYVALLAGQIIKDIEATEDSLFDDNKDKENRSPTKNDPFRIRIVNQATKLMSYFILDQELNKLISLHNIDWLYHHACVMLTHPKASKAIISAYLVIMKECKLSAKKKKALFETGDLAEKMLFALINMKRFPSSSLVSEQFMCFKNFVNLFPGIMAKNISHWFGMLLLNICEVGSPFYLKCFSVGVHCLLEVAKAFLDNRKTRAYVKLFLSSPFSFNIKSMSSSESIVIDSDSNDSQSQKVVDIVLSKLSELIHDGQFKEAMDIWVALTVLVGYSGESFERWEHLSKWLQITKLCFNSQVPQARVLALSCWKAIIFNLCRNDLDEIRKTLDPVMGHSNIKDKQQQITTVMKPKVKLLTYLFGSFNAAEMEDEVIDTLHNLFVAILYSTINPLVIKSRTKYLHILWDKVFQFVFINFYFKKDASNARMSQLGFAVLSKLIKSATPVNERNFNEVRCLSNEPVSINEVNSLPPRWIYSKFDKIMQNMILIFLSENLHVEDKIGFFIAFLASIKPIVKNEASVSPTTFDIIDNIPIVLSHLFKTNTLSHDLAIKLIVNLHDTFTSSLLVRRANKQDEIDTSNNIYLPVLANCSKSLSKEKYLEIFQLITQSLSHKKILVFIADYVQSGLKMEDVKAVISDILAKRTVELSSEELGLYGEICQYFDTGFETFVKKLIQTIVVVSDSEKMLNCFENLNITSWNYSIVIFLLLLLKNAPNKHIFQFTINLIEKMMKSNFIATLELLTVQDFEAEIFPLMDQIYTNSLQYSGETLFKICSLLKDYLEYKLKNSENHELVDRLLLGCYSVLGIDVSTLIQDDYSKYPNFKIELDKRNSCIVNGKIVVNHLQKSQESDDKSSQEQETSVPTDSDNSLDLQVDSNIQKEQDVSESNEYDQSNIPELSADSSTSISDINTVDTVNKNIATEISSKSNLPEVEQVCKVNDIIVTDTECAKDESKVQPTEEFESVIQRNEGGLGLTVKLTPVKNRSAIETVSPKQEFIVKIVKKKPEEQVQESSSSAKDDDEISDIETSSVSQGNGNGIIEQPEVSSSRSSNGTLVRKREHPEESLAPSKRSKVCESTNSAEDGLKVTKTQLNANEKSLPLDDEIALENKQGELKMSKVDVDFNGQQGENIQVDSCNFSSINNNSSDPKTFAESIVSTDGEEKSENGEIPPAKELDIECTTSPDLKNSDNSAILETNNDINKKDTEEEKEKMKEEQYSMVQEAPSYFLPLKEFEEIKSKKEIDDDFENSVGYRSNGISKSYSPMDLVDLLSTKSDAELACITSDEKYEMETKLLNLMVRLRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDM9</accession>
    <name>A0A1D8PDM9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carboxypeptidase</fullName>
            <ecNumber evidence="12">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">PRC3</name>
        <name evidence="14" type="ordered locus">CAALFM_C105770CA</name>
        <name evidence="13" type="ordered locus">orf19.10011</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in degradation of small peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="12"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718495.2">
        <property type="nucleotide sequence ID" value="XM_713402.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDM9"/>
    <dbReference type="SMR" id="A0A1D8PDM9"/>
    <dbReference type="STRING" id="237561.A0A1D8PDM9"/>
    <dbReference type="GeneID" id="3639889"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105770CA"/>
    <dbReference type="CGD" id="CAL0000190176">
        <property type="gene designation" value="PRC3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05770C_A"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDM9"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009026856" description="Carboxypeptidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000190176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW26241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="550" mass="61945" checksum="FDB3D19DF2CAFB72" modified="2017-01-18" version="1">MQLSTLVTWLAALTVGAQAVSFGNNLKDQIILDSEESSPDLYLESVFKDLGSLPVDLITAWAEMQSELSPEQIAKLINQYESKNEKPKKNKFNPMSTFSSPSSKFEKLSNDKFAGYSMRVKESFPEILGLDTVKQYTGYLDIDSLDKHLFYWFFESRNDPKNDPIILWLNGGPGCSSSTGLFFELGPSSINKTLHPVYNPYSWNSNASVIFLDQPVGVGYSYTGGDEVKNTLTAAKDVYVFLELFFQKFPQFLTNKFHIAGESYAGHYIPAFASEIINNADRSFELASVLIGNGITDPLIQDGSYKPMGCGEGGYKPVLTTEQCDQMERDYPRCAKLTKLCYSFQSALTCVPAQYYCDSRLFQPYAQTGLNPYDIRKDCAEQGGNCYVEMDYLDEYLNLDYVKEAVGASNIDIFTSCDDTVFRNFILDGDEMKPFQQYVAELLDNNVPVLIYAGDKDYICNWLGNLAWVNELEYSDSEHFAPKPLQLWKPDGKKAAGEVKNHKHFTFLRIYDAGHMVPFDQPENALSMVNTWVQGDYSFGLEGNKLSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDT7</accession>
    <name>A0A1D8PDT7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C106340WA</name>
        <name evidence="5" type="ordered locus">orf19.13656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="9 10" key="2">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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        <scope>GENOME REANNOTATION</scope>
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    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716308.2">
        <property type="nucleotide sequence ID" value="XM_711215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFC1"/>
    <dbReference type="SMR" id="A0A1D8PFC1"/>
    <dbReference type="FunCoup" id="A0A1D8PFC1">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFC1"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PFC1"/>
    <dbReference type="GeneID" id="3642023"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112240CA"/>
    <dbReference type="CGD" id="CAL0000183506">
        <property type="gene designation" value="orf19.12703"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12240C_A"/>
    <dbReference type="eggNOG" id="KOG2105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFC1"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043905">
        <property type="term" value="F:L-seryl-tRNA(Thr) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000023">
        <property type="entry name" value="Alanyl-tRNA synthetase-related protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000012">
        <property type="entry name" value="Threonyl/alanyl tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000183506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="470" mass="52199" checksum="C8A80D3DADE4766F" modified="2017-01-18" version="1">MATTATGTTTAIVGALACQKNSFLKTFNTKVVSSYEFIPPPTAKDKQNKNNNKKKDVAVSKEFGVELEDTILFPEGGGQPYDKGTITLLPDNTKIIEVKSVLRDKLKAIHLVDELIEPGTQVRLNVDWGRRLDIMQQHTGQHLLSAVFDTYKLETLSWSMGETKDDINYIELPRKIDNDLVVEVQNKVNQLIVDSIPITVVTSDQHGHGHGQEHEHEHEHEHADVDISHIPDDYDLSQGGIIRIVKIGELDANPCCGTHLTSTAQIQSIALLHQSPIRGGHSRLYFICGGRVANHLRKEHEILKNVSTNQLSCSIDAVEEKIELLSLNYKKTNSTLNNLLKELASIEANKIFQNFKTHDNNNSKLAYVYRADLPEYLTWVQKELTTLINQDKTGDVDLSNKQTLVLLSGAAPNGGTIKILGPKAEELQKELKSKLSNLKGGGKGSSFQGKITKFEKGELEAVLKYLDSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFC8</accession>
    <name>A0A1D8PFC8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="6">4.1.1.48</ecNumber>
            <ecNumber evidence="5">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">TRP3</name>
        <name evidence="18" type="ordered locus">CAALFM_C112210WA</name>
        <name evidence="17" type="ordered locus">orf19.12708</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two components I and two components II.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="6"/>
    <dbReference type="EC" id="4.1.3.27" evidence="5"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716312.2">
        <property type="nucleotide sequence ID" value="XM_711219.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFC8"/>
    <dbReference type="SMR" id="A0A1D8PFC8"/>
    <dbReference type="FunCoup" id="A0A1D8PFC8">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFC8"/>
    <dbReference type="GeneID" id="3642035"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112210WA"/>
    <dbReference type="CGD" id="CAL0000192837">
        <property type="gene designation" value="TRP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12210W_A"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFC8"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="15">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="16">
        <location>
            <begin position="231"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000192837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW26840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="520" mass="58271" checksum="48742A0FC3140441" modified="2017-01-18" version="1">MTTDISSKRHVLMIDNYDSFTWNLYQYLHQSPKCGKVDVYRNDKITISQIENEIKPDIIFISPGPGHPLTDSGISRDIIKYFSGKIPIFGVCMGQECIFDVFGGDVSYAGEIVHGKTTTIKHDGKGMFENVPQSVAVTRYHSLAGSSKSLPDVLEVTAVTETQPEVIMGVRHKKYTIEGVQFHPESILTESGQLMIDNLLGVYGGTWEENDAIKTGKSIKINNKNGGENILQKIYKQREIDYESIEKLPGKSFENLQIELDLDLAPPLINFYDRLKYTRSNLKETIILSEFKRASPSKGDININAHPANQALTYSTNGCSTISVLTEPHWFKGSLDDLTLIRKVIDKPTTKDYKRPAVLRKEFIFNKYQILESRLAGADTVLLIVKMLNDETLLHELYQYSLKLGMIPLVEVNNSDELSQALKLTHKGTTEDPLIIGVNNRNLTTFDVDLNTTSNLVKQAKTSDRKGDVLVLALSGISSVDDVKKYKYEDNVDGFLIGESLMRAEEKGEAGKFLHDLCTC</sequence>
</entry>
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    <accession>A0A1D8PG05</accession>
    <name>A0A1D8PG05_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 8, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C200090WA</name>
        <name evidence="1" type="ordered locus">orf19.9469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710478.2">
        <property type="nucleotide sequence ID" value="XM_705386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG05"/>
    <dbReference type="SMR" id="A0A1D8PG05"/>
    <dbReference type="GeneID" id="3647910"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200090WA"/>
    <dbReference type="CGD" id="CAL0000183289">
        <property type="gene designation" value="orf19.9469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00090W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PG05"/>
    <dbReference type="OrthoDB" id="4015782at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000183289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW27064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23537" checksum="CE745838787A11C9" modified="2017-01-18" version="1">MRAYNHPILVNPTRWLRGPKKHAAALYQNGYYPSLDNNPFALALARLDANSPSSTLPIGNGIPLTVTQQDNHHVLTPTLNDTIEPSRLIVNSARYIKLIVDRPKAIQKLVPLQFIQQCKSSKAKVGMDRDMVDVIDKMYRQRIEELLEDVGNESGESGIILKPMDVPVRIEGSTTYVNNIFTTHPKFINYTHRELSQLILAYTDFVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG11</accession>
    <name>A0A1D8PG11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRP18</name>
        <name evidence="11" type="ordered locus">CAALFM_C200200WA</name>
        <name evidence="10" type="ordered locus">orf19.9660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719558.2">
        <property type="nucleotide sequence ID" value="XM_714465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG11"/>
    <dbReference type="SMR" id="A0A1D8PG11"/>
    <dbReference type="FunCoup" id="A0A1D8PG11">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PG11"/>
    <dbReference type="GeneID" id="3638903"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200200WA"/>
    <dbReference type="CGD" id="CAL0000183835">
        <property type="gene designation" value="PRP18"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00200W_A"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PG11"/>
    <dbReference type="OMA" id="RRWIISI"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000011">
        <property type="entry name" value="Pre-mRNA-splicing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="152"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000183835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="270" mass="31062" checksum="3837187F02155A31" modified="2017-01-18" version="1">MDFSNLLSNEINKKRKKVAANGRKRSKVSTTAKEPAVVVEHAPETINPQPTTTNDEPSEEQLDTKLSQFGELDTSLSKSEKARKLQLLLQQQIKNTKYKAWLDQEAPLYQDPEKQLITLDLITDITNKQDEVYLKLRVYIKQLIKQWQECDNDDQELLMETKKSIVKLLYKLRSHKLSLDMLISLSTIVYYIQQNEFNKANESYMKLSIGNVCWPIGVVNVGIHARSAASKITGASNVSNIMLSESTRRWIISIKRLISFKERVYNNARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGJ6</accession>
    <name>A0A1D8PGJ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C202140CA</name>
        <name evidence="1" type="ordered locus">orf19.1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722574.1">
        <property type="nucleotide sequence ID" value="XM_717481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGJ6"/>
    <dbReference type="GeneID" id="3635748"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202140CA"/>
    <dbReference type="CGD" id="CAL0000201561">
        <property type="gene designation" value="orf19.1530"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02140C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PGJ6"/>
    <dbReference type="OrthoDB" id="4024310at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000201561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW27254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="173" mass="20217" checksum="0574B89E3CBCF42A" modified="2017-01-18" version="1">MLYILINYSNQFVEFIIMRILSIDFPTSLFHSTTQGWNQTPPHETKNPTVSIAHTLKNFLLWLIFINLINHYISNFKLYFGEIDIVLLLSNSSLEPISSTNVSPLSTMKEINKFIINQDLENILRGIYVRNEDIYLNNINQTTILCQPIIMCNDNSIQMLFLEKFYNDNQGNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGY8</accession>
    <name>RS9B_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S9B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS9B</name>
        <name type="ordered locus">orf19.838.1</name>
        <name type="ORF">CAALFM_C203820CA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS9B is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330762.1">
        <property type="nucleotide sequence ID" value="XM_019475217.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CW/L=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="CW/L=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="CW/L=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CW/L=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="K=1-189"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
    <dbReference type="PDBsum" id="7Q0R"/>
    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGY8"/>
    <dbReference type="EMDB" id="EMD-13737"/>
    <dbReference type="EMDB" id="EMD-13741"/>
    <dbReference type="EMDB" id="EMD-13744"/>
    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PGY8"/>
    <dbReference type="FunCoup" id="A0A1D8PGY8">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGY8"/>
    <dbReference type="EnsemblFungi" id="C2_03820C_A-T">
        <property type="protein sequence ID" value="C2_03820C_A-T-p1"/>
        <property type="gene ID" value="C2_03820C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515104"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203820CA"/>
    <dbReference type="CGD" id="CAL0000197665">
        <property type="gene designation" value="RPS9B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03820C_A"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGY8"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000456547" description="Small ribosomal subunit protein uS4">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O13516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="11">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="12">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="189" mass="21720" checksum="A16A8E6D809EB747" modified="2017-01-18" version="1">MPRAPRTYSKTYSVPKRPYESARLDAELKLAGEYGLKNKREIYRIGFQLSKIRRAARDLLTRDEKDPKRLFEGNALIRRLVRIGVLSEDKMKLDYVLALKPEDFLERRLQTQVFKLGLARSIHHARVLITQRHIAVGKQIVNIPSFTVRLDSQKHIDFAHNSPYGGGRAGRVKRKNQGKGGEEGAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH55</accession>
    <name>A0A1D8PH55_CANAL</name>
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        <recommendedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">UGA1</name>
        <name evidence="14" type="ordered locus">CAALFM_C204190CA</name>
        <name evidence="13" type="ordered locus">orf19.8421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer and homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP017624">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="A0A1D8PH55">
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    <dbReference type="STRING" id="237561.A0A1D8PH55"/>
    <dbReference type="GeneID" id="3637329"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204190CA"/>
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    <dbReference type="eggNOG" id="KOG1405">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0000303"/>
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    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000181031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW27445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="471" mass="52662" checksum="1574B63FD0EEB711" modified="2017-01-18" version="1">MSSKSVSSLYFPEEPKEPVVVDSHAKSKEIADRLGKVFDNRGVYFVADYEKSVGNYIADVDGNVYLDVYAQIASIPLGYNNPALIETAKSDKMIRAIVDRPAIGNFPGKDTDEIVSEILKVAPKGQDKVWSGLSGADANELAFKAAFFYYQAKKRGYTTQFSEEEMKSVMQNEAPGSPELAILSFERGFHGRLFASGSTTCSKPIHKLDMPSFKWPKAQFPSYKYPLDKYAEENKKEDERCLKIVDDIIQNNKIPVAAVLVEPIQSEGGDNHASAEFFQGLRDITLKHGSLLIMDEVQTGVGATGVMWAHERFNLQPPPDLVTFSKKFQSAGYFFHDPEIIPNFAYRQFNTWCGDPARMILAGAIGQEILKHDLVKRAAEVGDYLFKKLEQLQEKYPKYIKDLRGKDRATFIAWSLESGEARNKFLSDMKTVGVNIGGCAEDSVRLRPTLVFEEQHADILVSAIDKLLGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH88</accession>
    <name>A0A1D8PH88_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADPH-adrenodoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ARH2</name>
        <name evidence="8" type="ordered locus">CAALFM_C204880CA</name>
        <name evidence="7" type="ordered locus">orf19.11004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714880.2">
        <property type="nucleotide sequence ID" value="XM_709787.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH88"/>
    <dbReference type="SMR" id="A0A1D8PH88"/>
    <dbReference type="STRING" id="237561.A0A1D8PH88"/>
    <dbReference type="GeneID" id="3643411"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204880CA"/>
    <dbReference type="CGD" id="CAL0000183664">
        <property type="gene designation" value="ARH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04880C_A"/>
    <dbReference type="eggNOG" id="KOG1800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH88"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000183664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="249" mass="27788" checksum="B06E6BA7B52ABFF3" modified="2017-01-18" version="1" fragment="single">MKPRFLSYTTRLLTKPFKVAIVGTGPGGFYTAHHLLNKSSPDVKLNIDFFEKLPTPYGLSRYGVAPDHPEVKNCEDHMINIMKDFGNSESRHKVRFLGNVEVGKDIALKELEGNYNSIVLAYGCTSADNKFSIPGADLPGVVPARQFVNWYNGHPDYYGENKYIPPPLDKVDTVSIIGNGNVALDVARILLADPREHWAKTDISVDAQQLLEKSTVKHVRIVARRGVLESAFSNKEIRELLELPAKFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHT9</accession>
    <name>A0A1D8PHT9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="12">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">OLE2</name>
        <name evidence="17" type="ordered locus">CAALFM_C207090CA</name>
        <name evidence="16" type="ordered locus">orf19.9804</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="12"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714854.2">
        <property type="nucleotide sequence ID" value="XM_709761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHT9"/>
    <dbReference type="SMR" id="A0A1D8PHT9"/>
    <dbReference type="STRING" id="237561.A0A1D8PHT9"/>
    <dbReference type="GeneID" id="3643503"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207090CA"/>
    <dbReference type="CGD" id="CAL0000198173">
        <property type="gene designation" value="OLE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07090C_A"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHT9"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="409"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000198173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW27708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="526" mass="60862" checksum="D6C7C11CC5EAADBE" modified="2017-01-18" version="1">MSKHSEDPIKGVKVQKRKVASIASTSSSTSTHQQLMNQATKMKRTKINEMKKQKQDFFKRINYSHLLTVVVLPLLAVLYVVLCKQSIVPENERTLYFTCIYYNITMLAFTSGYHKYFAHNSFKVKAELLKYYFCIFGSSCGLGSVRWWAGLHRAHHHFTDDTERDPYSIKRGFLFSHYAWLLKKPKLTKFYLDFLEQEFPEHAENQKVQNEIVLDKEIETEYNGEDIMRQNYDESLRNLLMWQQRTYLFWFFVTTILIPALITKYVCGDSIVHGILYPGILRMFLCQQSLLSTESICHLKRIQVTIPTQPFNDKNSSTNCNNPLVSFLTYGQSHQNYHHEFPHDYRVDNSYLTYDPTKWFIWILEQLGAVDELSRTPGNLIVQLKLQQQQLIINRTKSQLNWGTPISKLPLISPSDFKKIISSTSNKDRIYIVIQNIIHDITPFMDQHPGGVALLKASHGKDATKAFYGGVYGHSTAAVNLLATMRIGVLDDGDDEEVWRRVAREEREVSNSTDSRPGHHHTAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHW4</accession>
    <name>A0A1D8PHW4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">MCM3</name>
        <name evidence="16" type="ordered locus">CAALFM_C207350WA</name>
        <name evidence="15" type="ordered locus">orf19.9457</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713158.2">
        <property type="nucleotide sequence ID" value="XM_708065.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHW4"/>
    <dbReference type="SMR" id="A0A1D8PHW4"/>
    <dbReference type="FunCoup" id="A0A1D8PHW4">
        <property type="interactions" value="1151"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHW4"/>
    <dbReference type="GeneID" id="3645223"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207350WA"/>
    <dbReference type="CGD" id="CAL0000199452">
        <property type="gene designation" value="MCM3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07350W_A"/>
    <dbReference type="eggNOG" id="KOG0479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHW4"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000234">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="689"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000199452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="878" mass="98512" checksum="ADDBFC20748AFA2D" modified="2017-01-18" version="1">MDERFLNPPPTADQDDTNQPLDAIFGDRVRRFQEFLDRIDSNTGIDYRSIIKDMLIKSKFRLSVSIDEIREFDREFWLGLLNQPADYLPACERALRDTVLAIYDPQDPSFPHDSYDPNQQYYLSFKGAFGGHSLTPRSIDSSYLSKMVSIEGIVTRASLVRPKVIRSVHYAEKTGRFYAREYRDQTTSFDAIATPAIYPTEDMEGNKLTTEYGYSTYRDYQKISVQEMPETAPPGQLPRSVDVILDDDLVDLTKPGDRVQIVGVYRALGGAANNSSSFKTVILSNSVYLLHARSTGVASQEKLTDQDIRNINKLAKDRKIFDILSRSLAPSIYGFDYIKKAVLLMMMGGVEKNLDNGTHLRGDINILMVGDPSTAKSQVLRFVLNTASLAIATTGRGSSGVGLTAAVTTDKETGERRLEAGAMVLADRGIVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPVFGQYDVHKDPHKNIALPDSLLSRFDLLFVVTDDVNPTRDRVISEHVLRMHRFVPPGLMEGEPIREKSAVTLAVGDDETNEQELLEQPMFEKFNTLLHAGIQNKKSNNILSIPFLKKYVQYAKQRVQPVLTKGASDYIVTTYSSLRNDLIGNNQRNTAPITARTLETLIRLATAHAKVRLSKTVDVKDAKVAEELLRYALFKEVAKKTKKRQKTTSIVDSEEEEEDESDAEMENSDNEIMPRESTRRTRATAQTQPPQQQQASPSLTPEPPLGHRDDGDDDGVGEELEQFHLSSSQQQQQQQYLQPLTERSSSNIVSSTATNAISIERLNIFKRILAQVSRSALFANDQAAANYHDVTRAINEQMEQEDIFSEQELSAGFEVMSSENKFYLESDKIWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHZ2</accession>
    <name>A0A1D8PHZ2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sedoheptulose 1,7-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C207790CA</name>
        <name evidence="3" type="ordered locus">orf19.9748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
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</entry>
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    <accession>A0A1D8PIB6</accession>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="8 9" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
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            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:231623"/>
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    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="DFG10 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Steroid_dh"/>
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    </dbReference>
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        <location>
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            <end position="24"/>
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            <end position="257"/>
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        <location>
            <begin position="149"/>
            <end position="281"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000191358"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="282" mass="32641" checksum="706A913968AB4C20" modified="2017-01-18" version="1">MAIYDSQLTVVALYSLIIIAIYSAKFITPLNELLQYGKTVSQDVREHARLENNLIKQTIGFISKYFVVPKAWFVHFYITLFALSSLIFLASFNEPISSDPEKFKNLILIHRLLWVQGIRRLTECLTITNFSKTSKMNVSHYVVGLSHYILVTWATYLGLSKYGSHQVPNNYTVFDIVLIIGFAICSLLQFQAHYHLSTLVKYTLPDFKFVSSPHYFYEILIYTILLSFAIKDGFDMVSVTFFTAWLFVISNLSISSLETFSYYQKKYKEEFKLKWAVLPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK81</accession>
    <name>A0A1D8PK81_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
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        <name evidence="6" type="ordered locus">CAALFM_C305510WA</name>
        <name evidence="5" type="ordered locus">orf19.6986</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="294251at2759"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000181935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKQ6</accession>
    <name>A0A1D8PKQ6_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">FUN31</name>
        <name evidence="15" type="ordered locus">CAALFM_C306620WA</name>
        <name evidence="14" type="ordered locus">orf19.7451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716112.1">
        <property type="nucleotide sequence ID" value="XM_711019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKQ6"/>
    <dbReference type="SMR" id="A0A1D8PKQ6"/>
    <dbReference type="FunCoup" id="A0A1D8PKQ6">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKQ6"/>
    <dbReference type="GeneID" id="3642249"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306620WA"/>
    <dbReference type="CGD" id="CAL0000200971">
        <property type="gene designation" value="FUN31"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06620W_A"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKQ6"/>
    <dbReference type="OMA" id="MDESECR"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060917">
        <property type="term" value="P:regulation of (1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="873"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="993"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000200971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1323" mass="149216" checksum="E5AC118F24274DA0" modified="2017-01-18" version="1">MTSNRPPPPSLSFFIEDNPTAQQPQEHHQQSLLNPNASANRPPIKCTTTNSRFNSQSQLRYESNARPNRSSPLFTSSPTFANYNNKPPTPSANGDDNGNSDIEDILKFPIESSHAYSYAHLSPNSLALRLNVLKRSLEILKDRPELFKSLTTTNSATNSPVQSSAPPTATSINISIDEASPLFRSASHPVEIDTNMSTEDLSLQPPPLRKTLYMQTNHSSDYIHDVSGASSLSANEHKNYKLRSNASSAALAALFRPTMKRSDSLPLNNNTSIPVTGRRVSTPPLVRELPTSRKTSSSKNKNDDFKDIIDLLENDLSALLDNSEVATTLHDLSLSTPDNLDDTNSNHDILKHKLLHALAMPFIENSVQPTSLLEFDGTSDPSLNSSHVRPSTTALNLLNNNYDEPPAKNRFNNNNNNNFKNSAASRPFHSLLTTKHALPQSVFTVDKDLPFSVKAANDLACLMFGVSKNTIKALTLMDLIAPQFRDFVLKRITGVQIMENKKNRDRILFAGEIVAIVRPGDQNYSWTSLWAKRKGNLIICMFDQIPCDAFDVVISSEKDVIDYKIDSINEIAGSLIEDYGIQNLSSLNSLSYSLNKELLEFHHNNEAEQDAIDETDQTNHTNNTNRDSFDIDEYYDEDIELINQTRYYTLQLEDENNVPCAITSTPLESDQEKHEIKLKIHTMPYIAGIFVIDSNEYKILSCNNAIARNLFGKSFDELENHSIDELIPNFTKILHAGIEATSNYAYQLSPGLVLPEHFFRKYDAFIKKQQNPENDQESKETIFFNSKGIEAVHRDGKVVYIDVQVRVSTNNTLVVWVTYSRTNKNRTNISEELDKLSSASTSSSISLASSNKSAVSLSSISKPRTYSSGLQLSDLKQQQQPQHSPSSSSQFLTKPSQQQSANSLQNIGGHERKLTTTSTVPSQMKLFNNEKENDLLEFSPREITRASSTRKPKKETSLGIPLTRLDSYIYDKNGREQQNLQRKEEKKPAKDLQNPSSEPTLSSPLALSSQADDSVKTDFNIVLKYTQEEILELENESLEQIKCQSSHWPKDVGTQRRTKKFSEFKVLKDMGEGAYGKVVLAQHKQDPLYKIIIKCINKERILVDTWVRDRKLGTIPSEIQIMAYLNSEPHPNIMRIIDFFEDSKYYYLETPIFGDPPAIDLFDFIEIKKDLSEVESKFIFKQIVSSIYHLHKNGIVHRDIKDENIIVDEKGVIKLIDFGSAGYVKQGPFDVFVGTIDYASPEVLGGEKYEGKPQDIWALGILLYTMLYKENPFYNVDEIMEGDLRIPYVISETSLTLIKKILVRDVDERPTITDIMEDEWLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLL4</accession>
    <name>A0A1D8PLL4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rgt1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">RGT1</name>
        <name evidence="10" type="ordered locus">CAALFM_C402540WA</name>
        <name evidence="9" type="ordered locus">orf19.10261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720497.2">
        <property type="nucleotide sequence ID" value="XM_715404.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLL4"/>
    <dbReference type="FunCoup" id="A0A1D8PLL4">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLL4"/>
    <dbReference type="GeneID" id="3637920"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402540WA"/>
    <dbReference type="CGD" id="CAL0000176948">
        <property type="gene designation" value="RGT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02540W_A"/>
    <dbReference type="eggNOG" id="ENOG502QRVJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLL4"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="419"/>
        </location>
    </feature>
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        </location>
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            <begin position="17"/>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="463"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115305" checksum="71BF0FFD8A6E4E1C" modified="2017-01-18" version="1">MTTTTIANQIPSINTMLSNVNNNNTPSANSSQSTLINQEQQQAQQQAQQQAQQSQHHRQHQSRSGGTTTNNNYSSSSDPPRKRSKVSRACDPCRKKKIKCNAEYSELEKKVTKICTSCAKNKEICTFDRTPLKRGPSKGYIRDLEEKAGDRISSLSSKSNQASTKANIPFPPSHQYPPPPQQQQKQQSPSIAIIPPNPYPPSNIQQLPFPQNSTTHRVTGSISNTPNNNNNNNNINNGNSPTIKLPPIVNYPSKSLPSPSLSKFNSSISSSQTSNPSSPKSQLSNIPGLLNNDSNTNNNVGGGGGGGGSEQTNSPPIQGPFWKVPYEMPQSSLSRRSSIGSITSTNGGQPNILRRPSVESISSVSTNGSRLPSIRPSISNDYTSDAESEDFYSVQSFRPRSLSRNSQSLSPRNSISSMSSLNGRINRSLAFNSSSVTSPIMIGSPSQQAQVQQQQSQSQLQLQQPPPPPPSSNMTNFMPPQVPIFAPFATTNHIPLNPLDLNLKLYYERFHTIFPILPYDSRIIYNILNDKSQPPWDWLIEVFNHSLNNLINFQQVELQSSIGIFIRLIQSYPFPNETTTTTITDNSLILFFSSLIILSYTNLINGDQYNAGISFTSSVFNDYKICERFIDQITNNKKDNDINVDVNVDVDNIVNYFTKLYYCLNLIDNLNSLTLGTNKNLHSQRIIKFLNHHKKKFLQINNNNNNNNNNNNSILNDCEIFDQLVEMRDKFITIDNTNYQGDDDVNEIINIDLINFNESKSSIHNNTNSNNNNNDDQFLKYFHQLIIDKYKIFKIILQFTKTNTSTSSSTTTTINGTTISNISNNGNNNSIEINSFNQELFNLIKSSNDNILNFANYISTTNNNNNNTSPKTSNSNSNSNFSYLIINNNPILNLSICQLFKSIKLHKLIIDKLPPPTTTTKTTISNDLDIDIDRLNNQLSISFNLLNLNLQNLKIGNMINQILQNKFNQLYKFQFNKSTDNNDIVDVDVDVDDIDMDMDIYKLNQWYDELNHVIVPFIIQDFKDGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLM1</accession>
    <name>A0A1D8PLM1_CANAL</name>
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        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
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        <name evidence="5" type="ordered locus">CAALFM_C402660WA</name>
        <name evidence="4" type="ordered locus">orf19.10248</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38076" checksum="B33D12C0E1F735B1" modified="2017-01-18" version="1">MSSIFPKLSFQEWYQVLYGLWPSNPQFTEKDISSNTLKDKVVVITGGNSGIGYETAKVLAGNTEARIYIWARNRQKSIEAIEKIKLEVAEKHSKDVGDRLQFIQIDLSDLNSIEPAVKEFLQREQRLDIIYHNAGVMESPSDQKTKQDYQMELGVNCIGPQLLQTLLDPLFIKTAEKNPPNLSRIVWVSSTAHMFSPIGGMYLRDPEFKSIDVELKTKYDQSKAINLIQARQWNIHHPGANAISLSLCPGYLKTGIQRHVTGLTKLAYNLFFHDQKMGVYTLLFAGLSPEITTKNKGDHVISFGKLGLIRPDLKDDENGKKVWDYLQDKIKSYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLQ2</accession>
    <name>A0A1D8PLQ2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">orf19.10206</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720444.1">
        <property type="nucleotide sequence ID" value="XM_715351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLQ2"/>
    <dbReference type="SMR" id="A0A1D8PLQ2"/>
    <dbReference type="STRING" id="237561.A0A1D8PLQ2"/>
    <dbReference type="GeneID" id="3637935"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403000CA"/>
    <dbReference type="CGD" id="CAL0000189321">
        <property type="gene designation" value="orf19.10206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03000C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PLQ2"/>
    <dbReference type="OrthoDB" id="4014994at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000189321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="240" mass="28184" checksum="A6B8C637402CAC0D" modified="2017-01-18" version="1">MIPPTTNKNKFKQKWTKIKLRFRKNKTHEVDDQVTIVVRSSYDSCVKCMGEKLPLDELTDISTQIHPQQTSPFKEKMILETAKHIENKQEKLDQAVELSCSVVSSPRHPQPQYQMQPQPQPQLQHQQLPSYPPPKYQPRSIPPTIKYKSQLNQYLLDKASDPKPYTSISSYYMNLHNSFANYYLIVQDGSYQCVNYKSLEPEIEDSSRLLKSHYRFFYGFFVLYISIFVIYIYVVTTQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN05</accession>
    <name>A0A1D8PN05_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nrd1 complex RNA-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C500790CA</name>
        <name evidence="9" type="ordered locus">orf19.8214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
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                <person name="Jones T."/>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Weissman J.S."/>
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</entry>
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <source>
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        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="393" mass="44711" checksum="6EC73A94C11F2873" modified="2017-01-18" version="1">MSETNNPASSNDKKPVVFAVPSSSTRRGINAVHVNSAREMVRLHTQGRNPPAARQANVPSIPSRVVEASHAPTKKATDSMPSKFPNIQIPLHHDETECKNPQCQHCGQIIIPSPQSSYPIQDKPSISVNGWSVFTTKKPILNSLELDHLAETKFEFPLPEMIFGNNNVRIRNDVTGGTIEFNAIDALSSLDPNCPLKVSCHEEWLKSRRSKHASLKQEQSLKKDLSEFTENLDGLKPYDWTYSTNYKGTLQNLDLKSSTLHEIPIDKLTKPDPILFFDEAILFEDELADNGISILSYKIRVMPTCLLLLCRFFLRIDDVIFRVRDTRCYIDFETNTLTREYKVQEQEYDKVMSLVKVKNNKDPKKLFRDSNWVSQNIPVLNKEIETIVVNTET</sequence>
</entry>
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        </submittedName>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721893.2">
        <property type="nucleotide sequence ID" value="XM_716800.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="3636423"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504960WA"/>
    <dbReference type="CGD" id="CAL0000181504">
        <property type="gene designation" value="orf19.11467"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04960W_A"/>
    <dbReference type="eggNOG" id="ENOG502QSA6">
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    <dbReference type="OrthoDB" id="4068467at2759"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="11">Grf10p</fullName>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW29912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C505080WA"/>
    <dbReference type="CGD" id="CAL0000184581">
        <property type="gene designation" value="GRF10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05080W_A"/>
    <dbReference type="eggNOG" id="KOG0486">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PP44"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:nucleus"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Caudal_homeobox"/>
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        <property type="entry name" value="HD"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF9">
        <property type="entry name" value="HOMEOTIC PROTEIN CAUDAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="21"/>
            <end position="36"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="367"/>
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            <begin position="430"/>
            <end position="457"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
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        <location>
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            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="665"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
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    </evidence>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000184581"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29912.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="685" mass="76299" checksum="9E327F5C3151BE5B" modified="2017-01-18" version="1">MSPDSISSSVNQDLSTPTPPTSLSSTSTNSNTNASSGQKRIRATGEALEFLISEFETNPNPSPERRKFISDKAQMNEKAVRIWFQNRRAKQRKFERQMLRKETDSPGNYAGIYNTYTPNPPTVTTDMTNFNVNGSAGGATADFNDKLKNISSIPVEVNEKYCFIDCRSLSVGSWQRIKTGFHQSNLLTNNLINLAPVTLNQVMSNADLLIILSKKNLELNYFFSAISNNSRILFRIFYPLNAVVKCSLFDNNYYQNNNTNGTNSSDDNNISEIRLNLCQKPKFSVYFFNGSNTNNQWSICDDFSEGQQVSCAFAANDNSLPSNGKNQSFSNTIPHVLVGSTLSLQYLSQFILQHQQRQRQQQRQAQPQPQPQPHNQFDFNSQPFETIPTSAINNNFNTTKTVNSSSMQGFVPGDFQDLPAIYESISNSNHTTTTDLKDTNATTTTTNKHTPSSTTFTPQNLNGSNQSQTNVTYTNNYNESPFSIASTTNNNNTNSNRSNSQSHNPIFSDQLFYESSESASTNSPQFAMKKMNSETKLYINGNVSSNSSTNGPPLDDDNNLFDGVTRFTTTETSPEDDIIGMFTSQAHEPSAFELANGVTSSGSSYTHINNGSLTKSDKTFTGLSETSNNNNNTNGINFVDDFHVGNEFGDIDFEHHYSQDHHQQQQKNDNNNGNTNLDSFIDFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP67</accession>
    <name>A0A1D8PP67_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Riboflavin synthase</fullName>
            <ecNumber evidence="5">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">RIB5</name>
        <name evidence="13" type="ordered locus">CAALFM_C505300WA</name>
        <name evidence="12" type="ordered locus">orf19.11507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721932.2">
        <property type="nucleotide sequence ID" value="XM_716839.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP67"/>
    <dbReference type="SMR" id="A0A1D8PP67"/>
    <dbReference type="FunCoup" id="A0A1D8PP67">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP67"/>
    <dbReference type="GeneID" id="3636499"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505300WA"/>
    <dbReference type="CGD" id="CAL0000190137">
        <property type="gene designation" value="RIB5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05300W_A"/>
    <dbReference type="eggNOG" id="KOG3310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP67"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719089.1">
        <property type="nucleotide sequence ID" value="XM_713996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPX1"/>
    <dbReference type="GeneID" id="3639204"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602550WA"/>
    <dbReference type="CGD" id="CAL0000179889">
        <property type="gene designation" value="orf19.12970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02550W_A"/>
    <dbReference type="eggNOG" id="ENOG502RQCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPX1"/>
    <dbReference type="OMA" id="WELLEYD"/>
    <dbReference type="OrthoDB" id="4079109at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048920">
        <property type="entry name" value="REC102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21736">
        <property type="entry name" value="REC102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000179889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="235" mass="27164" checksum="F21A06D1355D9396" modified="2017-01-18" version="1">MSLSIRLLENYYQIQYSYLCTNPQLLNTATPSANFVIHVDISINNNTLTTKTFDSQLITGLASRFVKFWELLEYDVNLNISDDSSHSFNMGLKCKIFELYAPTNCLLSLNLKLSILTQENTIHLEDMCTNFNYLLSSWNLFMETQAPFVFSVIGRQYAKTNIFWYRRVRRDVLKYDSMDLDKVLILLEDKISHNFTVQQLLLQNVKLQSVLESTSPVSRKRGSGAIKSYPVVLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ07</accession>
    <name>A0A1D8PQ07_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">HPD1</name>
        <name evidence="11" type="ordered locus">CAALFM_C602890CA</name>
        <name evidence="10" type="ordered locus">orf19.13011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719127.2">
        <property type="nucleotide sequence ID" value="XM_714034.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ07"/>
    <dbReference type="SMR" id="A0A1D8PQ07"/>
    <dbReference type="STRING" id="237561.A0A1D8PQ07"/>
    <dbReference type="GeneID" id="3639239"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602890CA"/>
    <dbReference type="CGD" id="CAL0000185703">
        <property type="gene designation" value="HPD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02890C_A"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ07"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-18957"/>
    <dbReference type="BRENDA" id="1.1.1.59">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047565">
        <property type="term" value="F:3-hydroxypropionate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902859">
        <property type="term" value="P:propionyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000070">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001411">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="207"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000185703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="354" mass="39045" checksum="48F88308137C0067" modified="2017-01-18" version="1">MLRTSIRAFSTQPRLSTNYGFIGLGLMGQHMARHVYNQLEPSDKLYVYDVDPKHTTQFLTEVTSQTPQNAPLLTPLNSLKDFTTEVDSQLDFIVTMVPEGKHVKSVVSELVGHYKSTGNYDPSIKTTFLDSSTIDIPTSRDVHQLVKSSIPEFDFIDTPVSGGVAGARKGTLSFMLSRETHDDIDPSLTALLSKMGINIFPCGATHGTGLAAKLANNYLLAITNIAAADSFQLAESFGLNLQNYAKLVAVSTGKSWASVDNCPIPGVYPDNNLPSDVNYEGGFITKLTRKDVVLATESAKFNNRFLMLGDIGRHWYDKACEREDIANRDLSVLFEWLGDLKQNEKGDVIDVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ09</accession>
    <name>A0A1D8PQ09_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative lipoate-protein ligase A</fullName>
            <ecNumber evidence="6">6.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Altered inheritance rate of mitochondria protein 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C602900CA</name>
        <name evidence="14" type="ordered locus">orf19.13012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[lipoyl-carrier protein] + (R)-lipoate + ATP = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="6"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_714035.2"/>
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        <property type="interactions" value="272"/>
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    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="201621at2759"/>
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        <property type="reaction ID" value="UER00595"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LplA"/>
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    </dbReference>
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        <property type="entry name" value="Putative lipoate-protein ligase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="13">
        <location>
            <begin position="122"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000187056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW30221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="453" mass="51581" checksum="EDBC2F26DE090E8B" modified="2017-01-18" version="1">MFLRRALPRNLLLIQRRRISNVNVPFEDDLTGFEDDSLADFQHYPGLQQSTPVDQNNTPSTKTDKTIAQAPLQETTIIPQLSKISQLRNPVIFVSKLTNPYMNLAIEDYIYNAMPKPEGAKDNSFDRLMFYINTPCVVIGKNQNPWQEVNLPVLNSLGVPMLRRRSGGGTVVHDLGNVNYSYMTTKANFDRHKFASYIVEAVNQASPRFKIETNERGDIVSEKLLGLNYKISGSAYKLSKGKSYHHGTMLLNSKLDVLGKLLHRDEKKLGIVDSKMSIPSVKSKVINLEMKSDKFIDVVSQKFKSLYNVVPEEDTEMDEFNEMFGLTDFAKSQEVTLFVIDEATTIPEEIHITADELKQWSWRFGHTPKFTHSFKNQKHGLEILFNVEKGCLKSFKLTFDDSNSDTKEIEKSFQYLESHIKNNDLEYTGSNVAGFVLHDEISDWIGESIDGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ24</accession>
    <name>A0A1D8PQ24_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C603000CA</name>
        <name evidence="2" type="ordered locus">orf19.13025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719141.2">
        <property type="nucleotide sequence ID" value="XM_714048.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ24"/>
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    <dbReference type="CGD" id="CAL0000178848">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03000C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQ34">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000178848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="268" mass="30952" checksum="FF40D2506C57D3E9" modified="2017-01-18" version="1">MNKEIHEGEKILSGTILRVPLIIEDKATSETIKNSSLWLHVSGADYEPSNNPLFINKSLTAICSEGYFHKTLTTDNSNRVFRRYIPNIDLSNDKHFELLNNLFPLDLESLIEAKQTTKAPTQQQQQQLKLMAKLISDKSNYDANNEYLDDIEPNKNNIVLSIKTDAKYAVTIGTIELPPVDIENNPYLNDEENLLNWMELYNSQNESLLELLIESNNNLDRLKSENQKLESNLELTKNDYDKIIEDLESKFYLVLNSKKDKIYELTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ42</accession>
    <name>A0A1D8PQ42_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ayr2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">AYR2</name>
        <name evidence="6" type="ordered locus">CAALFM_C603270CA</name>
        <name evidence="5" type="ordered locus">orf19.13060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719175.2">
        <property type="nucleotide sequence ID" value="XM_714082.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ42"/>
    <dbReference type="SMR" id="A0A1D8PQ42"/>
    <dbReference type="STRING" id="237561.A0A1D8PQ42"/>
    <dbReference type="GeneID" id="3639184"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603270CA"/>
    <dbReference type="CGD" id="CAL0000201074">
        <property type="gene designation" value="AYR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03270C_A"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ42"/>
    <dbReference type="OMA" id="IWFLNAV"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000201074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="297" mass="32804" checksum="4C7DE16E89441D34" modified="2017-01-18" version="1">MSPKYALVTGASSGIGYNLAIELSKKGYKVIGCSPQSVLFGQKPLEQEYGVISLPLDVTDIDNIKTVLKKVEEITGGRLDVLYNNAGISISGPAIEIDETQLNKVFQVNVIGQINMTKYFAPLIINAKGTILFTSSVAARVPLSWVSAYNATKAAIDAYALTLHGEMAPFGVRVHSVITGGVDTAICDGNIKTSLGDSFYDVDGVYESIRSSAMMSRDLNISPEQYAKEVVRDIVSWRDPGFNLYHGARSYFLHWVSRFLPLWLVEFGVQIHFKQRRVLQTIAKLIKVKKSQEKKYV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-03-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ86</accession>
    <accession>Q7ZA78</accession>
    <accession>Q7ZA79</accession>
    <name>ALS9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Agglutinin-like protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Adhesin 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALS9</name>
        <name type="synonym">ALS11</name>
        <name type="ordered locus">CAALFM_C603710WA</name>
        <name type="ORF">orf19.13164</name>
        <name type="ORF">orf19.5742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Microbiology" volume="149" first="2947" last="2960">
            <title>Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9.</title>
            <authorList>
                <person name="Zhao X."/>
                <person name="Pujol C."/>
                <person name="Soll D.R."/>
                <person name="Hoyer L.L."/>
            </authorList>
            <dbReference type="PubMed" id="14523127"/>
            <dbReference type="DOI" id="10.1099/mic.0.26495-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>VARIANTS</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="30480" last="30489">
            <title>Functional and structural diversity in the Als protein family of Candida albicans.</title>
            <authorList>
                <person name="Sheppard D.C."/>
                <person name="Yeaman M.R."/>
                <person name="Welch W.H."/>
                <person name="Phan Q.T."/>
                <person name="Fu Y."/>
                <person name="Ibrahim A.S."/>
                <person name="Filler S.G."/>
                <person name="Zhang M."/>
                <person name="Waring A.J."/>
                <person name="Edwards J.E. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="15128742"/>
            <dbReference type="DOI" id="10.1074/jbc.M401929200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2007" name="Med. Mycol." volume="45" first="363" last="370">
            <title>Candida albicans Als proteins mediate aggregation with bacteria and yeasts.</title>
            <authorList>
                <person name="Klotz S.A."/>
                <person name="Gaur N.K."/>
                <person name="De Armond R."/>
                <person name="Sheppard D."/>
                <person name="Khardori N."/>
                <person name="Edwards J.E. Jr."/>
                <person name="Lipke P.N."/>
                <person name="El-Azizi M."/>
            </authorList>
            <dbReference type="PubMed" id="17510860"/>
            <dbReference type="DOI" id="10.1080/13693780701299333"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2007" name="Microbiology" volume="153" first="2342" last="2350">
            <title>Unequal contribution of ALS9 alleles to adhesion between Candida albicans and human vascular endothelial cells.</title>
            <authorList>
                <person name="Zhao X."/>
                <person name="Oh S.H."/>
                <person name="Hoyer L.L."/>
            </authorList>
            <dbReference type="PubMed" id="17600078"/>
            <dbReference type="DOI" id="10.1099/mic.0.2006/005017-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="FEMS Immunol. Med. Microbiol." volume="65" first="121" last="124">
            <title>Profiling of adhesive properties of the agglutinin-like sequence (ALS) protein family, a virulent attribute of Candida albicans.</title>
            <authorList>
                <person name="Aoki W."/>
                <person name="Kitahara N."/>
                <person name="Miura N."/>
                <person name="Morisaka H."/>
                <person name="Kuroda K."/>
                <person name="Ueda M."/>
            </authorList>
            <dbReference type="PubMed" id="22321066"/>
            <dbReference type="DOI" id="10.1111/j.1574-695X.2012.00941.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2012" name="Mycoses" volume="55" first="E151" last="E157">
            <title>Frequency and expression of ALS and HWP1 genotypes in Candida albicans strains isolated from Mexican patients suffering from vaginal candidosis.</title>
            <authorList>
                <person name="Monroy-Perez E."/>
                <person name="Sainz-Espunes T."/>
                <person name="Paniagua-Contreras G."/>
                <person name="Negrete-Abascal E."/>
                <person name="Rodriguez-Moctezuma J.R."/>
                <person name="Vaca S."/>
            </authorList>
            <dbReference type="PubMed" id="22429754"/>
            <dbReference type="DOI" id="10.1111/j.1439-0507.2012.02188.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="14 15 16" key="11">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="15775" last="15779">
            <title>Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans.</title>
            <authorList>
                <person name="Salgado P.S."/>
                <person name="Yan R."/>
                <person name="Taylor J.D."/>
                <person name="Burchell L."/>
                <person name="Jones R."/>
                <person name="Hoyer L.L."/>
                <person name="Matthews S.J."/>
                <person name="Simpson P.J."/>
                <person name="Cota E."/>
            </authorList>
            <dbReference type="PubMed" id="21896717"/>
            <dbReference type="DOI" id="10.1073/pnas.1103496108"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.49 ANGSTROMS) OF 18-328</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 8 9">Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections (PubMed:17510860, PubMed:22321066, PubMed:22429754). Allele ALS9-2 contributes to endothelial cell adhesion, whereas ALS9-1 does not (PubMed:17600078).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Lipid-anchor</topology>
            <topology>GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location>Secreted</location>
            <location>Cell wall</location>
        </subcellularLocation>
        <text evidence="11">Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter; domain that is relatively variable in length and sequence across the family.</text>
    </comment>
    <comment type="PTM">
        <text>N-glycosylated and O-glycosylated.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="AY269422">
        <property type="protein sequence ID" value="AAP34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY269423">
        <property type="protein sequence ID" value="AAP34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718078.2">
        <property type="nucleotide sequence ID" value="XM_712985.2"/>
    </dbReference>
    <dbReference type="PDB" id="2Y7L">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.49 A"/>
        <property type="chains" value="A=18-328"/>
    </dbReference>
    <dbReference type="PDB" id="2Y7M">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.98 A"/>
        <property type="chains" value="A=18-328"/>
    </dbReference>
    <dbReference type="PDB" id="2Y7N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=18-328"/>
    </dbReference>
    <dbReference type="PDB" id="2Y7O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.75 A"/>
        <property type="chains" value="A=18-328"/>
    </dbReference>
    <dbReference type="PDB" id="2YLH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=18-328"/>
    </dbReference>
    <dbReference type="PDBsum" id="2Y7L"/>
    <dbReference type="PDBsum" id="2Y7M"/>
    <dbReference type="PDBsum" id="2Y7N"/>
    <dbReference type="PDBsum" id="2Y7O"/>
    <dbReference type="PDBsum" id="2YLH"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ86"/>
    <dbReference type="SMR" id="A0A1D8PQ86"/>
    <dbReference type="STRING" id="237561.A0A1D8PQ86"/>
    <dbReference type="GlyCosmos" id="A0A1D8PQ86">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_03710W_A-T">
        <property type="protein sequence ID" value="C6_03710W_A-T-p1"/>
        <property type="gene ID" value="C6_03710W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640281"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603710WA"/>
    <dbReference type="CGD" id="CAL0000194750">
        <property type="gene designation" value="ALS9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03710W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PQ86"/>
    <dbReference type="OrthoDB" id="4023732at2759"/>
    <dbReference type="EvolutionaryTrace" id="A0A1D8PQ86"/>
    <dbReference type="PHI-base" id="PHI:11388"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043710">
        <property type="term" value="P:cell adhesion involved in multi-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1280:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2430:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000439168" description="Agglutinin-like protein 9">
        <location>
            <begin position="18"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000439169" description="Removed in mature form" evidence="1">
        <location>
            <begin position="1868"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 1">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 2">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 3">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 4">
        <location>
            <begin position="509"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 5">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 6">
        <location>
            <begin position="581"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 7">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 8">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 9">
        <location>
            <begin position="689"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 10">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 11">
        <location>
            <begin position="761"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 12">
        <location>
            <begin position="797"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 13">
        <location>
            <begin position="833"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 14">
        <location>
            <begin position="869"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 15">
        <location>
            <begin position="905"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 16">
        <location>
            <begin position="941"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 17">
        <location>
            <begin position="977"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 18">
        <location>
            <begin position="1013"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 19">
        <location>
            <begin position="1049"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1552"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1726"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1789"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1552"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1594"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1604"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1797"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated aspartate" evidence="1">
        <location>
            <position position="1867"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1175"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1475"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1818"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1821"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14 15 16">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14 15 16">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14 15 16">
        <location>
            <begin position="205"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14 15 16">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>LLLLLY</original>
        <variation>ILLFIS</variation>
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>DSLTWTRSVEYVYKG</original>
        <variation>NSLTWANAANYGYQT</variation>
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>N</variation>
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>A</original>
        <variation>P</variation>
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>M</original>
        <variation>L</variation>
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>S</original>
        <variation>T</variation>
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>DKA</original>
        <variation>ARV</variation>
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>IT</original>
        <variation>FS</variation>
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>M</original>
        <variation>T</variation>
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>KISTTVDFDASPVSPSGYITSSRII</original>
        <variation>EISTSVDFQASPISSSGYIASARVV</variation>
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>A</original>
        <variation>L</variation>
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>S</original>
        <variation>V</variation>
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>Q</original>
        <variation>N</variation>
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>S</variation>
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>SSSGIIVEYE</original>
        <variation>TSTSITVEFQ</variation>
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>SENVEQ</original>
        <variation>AENIDK</variation>
        <location>
            <begin position="281"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>K</original>
        <variation>E</variation>
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>W</original>
        <variation>T</variation>
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>N</original>
        <variation>D</variation>
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>K</original>
        <variation>R</variation>
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>A</original>
        <variation>D</variation>
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>S</variation>
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>IGIS</original>
        <variation>VGVT</variation>
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>F</original>
        <variation>L</variation>
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>A</original>
        <variation>G</variation>
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>N</variation>
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>S</original>
        <variation>T</variation>
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>QIPSPDPTTTITEFWSESFASTTTVTNPPDGTNSVIIKEPYN</original>
        <variation>ELPSPA</variation>
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="561"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>Y</original>
        <variation>H</variation>
        <location>
            <position position="577"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>V</original>
        <variation>F</variation>
        <location>
            <position position="607"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="645"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="669"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="679"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>K</original>
        <variation>M</variation>
        <location>
            <position position="682"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="685"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>T</original>
        <variation>R</variation>
        <location>
            <position position="712"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>K</original>
        <variation>M</variation>
        <location>
            <position position="718"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="753"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>P</original>
        <variation>L</variation>
        <location>
            <position position="781"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <location>
            <begin position="789"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="789"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="813"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>T</original>
        <variation>R</variation>
        <location>
            <position position="820"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>K</original>
        <variation>M</variation>
        <location>
            <position position="826"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>T</original>
        <variation>S</variation>
        <location>
            <position position="882"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="885"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-1." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="921"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>N</variation>
        <location>
            <position position="944"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>S</original>
        <variation>Y</variation>
        <location>
            <position position="948"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="1029"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>Y</original>
        <variation>H</variation>
        <location>
            <position position="1045"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="1065"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="1077"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>Y</original>
        <variation>H</variation>
        <location>
            <position position="1081"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>KTFYSSEAQSSLEIDSSNTFMTSISVS</original>
        <variation>TIFHSSEPHYSSDFDSSDSFVTLISVT</variation>
        <location>
            <begin position="1108"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="1149"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>ISSYSLSTSF</original>
        <variation>LSSYTWSSGL</variation>
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>L</original>
        <variation>F</variation>
        <location>
            <position position="1170"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>SSPS</original>
        <variation>NLPT</variation>
        <location>
            <begin position="1180"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>MYSSVTSAVTSIDNDREVPTSTTTYLHSKLYSESISTVI</original>
        <variation>VYSSTASAVASTDGDSVVPSSTNLVTQSISSSETYCIDISGCSSVRQSSSVMVTPSNSGRIIISDSAYLTTTYSHSESDLESIVTVV</variation>
        <location>
            <begin position="1189"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>L</original>
        <variation>S</variation>
        <location>
            <position position="1238"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>N</original>
        <variation>D</variation>
        <location>
            <position position="1242"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>STVSEESLHY</original>
        <variation>TTVSDDNSYS</variation>
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>M</original>
        <variation>V</variation>
        <location>
            <position position="1301"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>S</original>
        <variation>N</variation>
        <location>
            <position position="1308"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>M</original>
        <variation>L</variation>
        <location>
            <position position="1429"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>T</original>
        <variation>TTAESIATKTIVSETPVTKVLSSKSLAANASPSEPTSKKE</variation>
        <location>
            <position position="1488"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>D</original>
        <variation>G</variation>
        <location>
            <position position="1799"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="1859"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="1861"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele ALS9-2." evidence="4">
        <original>L</original>
        <variation>H</variation>
        <location>
            <position position="1875"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAP34370/AAP34371." evidence="10" ref="1">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="537"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAP34370/AAP34371." evidence="10" ref="1">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="705"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAP34370/AAP34371." evidence="10" ref="1">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="741"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAP34370/AAP34371." evidence="10" ref="1">
        <original>F</original>
        <variation>L</variation>
        <location>
            <position position="1886"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="24"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="turn" evidence="17">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="66"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="74"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="82"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="91"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="turn" evidence="17">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="106"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="helix" evidence="17">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="165"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="184"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="helix" evidence="17">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="195"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="257"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="286"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="294"/>
            <end position="297"/>
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    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="302"/>
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    <feature type="strand" evidence="17">
        <location>
            <begin position="307"/>
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        </location>
    </feature>
    <feature type="strand" evidence="17">
        <location>
            <begin position="320"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="14523127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15128742"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="17510860"/>
        </source>
    </evidence>
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            <dbReference type="PubMed" id="17600078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
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            <dbReference type="PubMed" id="22321066"/>
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    <evidence type="ECO:0000269" key="9">
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            <dbReference type="PubMed" id="22429754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="12845604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="14">
        <source>
            <dbReference type="PDB" id="2Y7L"/>
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    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="2Y7M"/>
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    </evidence>
    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="2Y7N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="2Y7L"/>
        </source>
    </evidence>
    <sequence length="1890" mass="201290" checksum="3E394E9A31CFF950" modified="2017-01-18" version="1" precursor="true">MLPQFLLLLLYLTVSTAKTITGVFNSFDSLTWTRSVEYVYKGPETPTWTAVLGWSLNSTTADAGDTFTLIMPCVFKFITSQTSVDLTADGVSYATCDFNAGEEFTTFSSLSCTVNSVSVSYDKASGTVKLPITFNVGGTGSSVDLTDSKCFTAGKNTVTFMDGDTKISTTVDFDASPVSPSGYITSSRIIPSLNKASSLFVSPQCENGYTSGIMGFVTSQGATIDCSNINIGISKGLNDWNFPVSSESFTYTKTCSSSGIIVEYENVPAGYRPFVDAYISSENVEQYTLTYANEYTCKNGNTVVDPFTLTWWGYKNSEADSNGDIIVVTTKTVTASTTAVTTLPFNPTVDKTETIEVLQPIPTTTITTSYIGISTSYETFTATIGGTATVIVDTPYHITTTVTTFWTGSVTTTTTYSNPTGSIDTVIVQIPSPDPTTTITEFWSESFASTTTVTNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTVTNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTVTNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTVTNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTTITNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTTVTNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTTVTNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTTVTNPPDGTNSVIVKEPYNPTVTTTEFWSESFASTTTVTNPPDGTNSVIIKEPYNPTVTTTEFWSESFASTTPSVSSFESKTFYSSEAQSSLEIDSSNTFMTSISVSTASSYDESSTIVSSAFPTLHISSYSLSTSFVPPVTLPRYVNTTISSSPSFESSSMYSSVTSAVTSIDNDREVPTSTTTYLHSKLYSESISTVIQTKSSDWSLSLGNSNKPESASTVSEESLHYLSTPGPSSSEYSISFTSEKEGHVSSYVPRVSYTSSVKVSISSTMSSENGMSATHTFGISTNTIPSSTETSIKSATVTTPVSESTNTGMSIFMSTTTESKTTDITTETSVSGEVNLGSATVKVSSSEFISKGTVTRIMPTELTNSESTFTASPSFVLTSTESSVIETPATIEMSSRSSSYSVPLSKLRSEGETTRVIPTSSTATGSTVIGSPSSVSTSNESIITGSSSFVSTTAETISTRSIVTESIVAGSPSLVLTTTVLDTTETTITETSIVGESSSRSLTFKASSLSKGEITGTVTPEMSVSTSKATTGTTSEVSIKESLTTKVPTFTSTTIKPETSETQHSESRTTQIPYSETKGSQLSTANSQVSQTGSSKSSIFESAISKDESTFVSATVKSITTPAVTQYQTSLPNPAVSVSEESGKKSSIIESQTENSATQHSIYFDSIETSTLSNTLANTLVSGAMKNSETTSELTTSDKAIGFSTTTETSIPGATNSALSPSVDSGKSSMLGWSGGIVSTVSTSTRLEDSTATSSSITAANQDSLNPSTVSKYPHGSETIDNGSNGSSHSSSALASTISASHSIKFSAHQTTLSQSLISSSTKTVIASTYDGSGSVIKLHSWFYGLVTIFFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ95</accession>
    <name>A0A1D8PQ95_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">SNQ2</name>
        <name evidence="15" type="ordered locus">CAALFM_C603840CA</name>
        <name evidence="14" type="ordered locus">orf19.13182</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713002.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PQ95"/>
    <dbReference type="FunCoup" id="A0A1D8PQ95">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ95"/>
    <dbReference type="GeneID" id="3640290"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603840CA"/>
    <dbReference type="CGD" id="CAL0000187456">
        <property type="gene designation" value="SNQ2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03840C_A"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ95"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_trans_N"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="ABCG_dom"/>
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        <property type="entry name" value="ABCG_PDR_1"/>
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        <property type="entry name" value="ABCG_PDR_2"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PDR_CDR_ABC"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="500"/>
            <end position="521"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="750"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="1222"/>
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            <begin position="1300"/>
            <end position="1324"/>
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        <location>
            <begin position="1453"/>
            <end position="1474"/>
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        <location>
            <begin position="142"/>
            <end position="391"/>
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    </feature>
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        <location>
            <begin position="839"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="799"/>
            <end position="829"/>
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    </feature>
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        <location>
            <begin position="1"/>
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            <begin position="13"/>
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        <location>
            <begin position="810"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    <sequence length="1495" mass="167718" checksum="A340CD4E395A0A65" modified="2017-01-18" version="1">MSSEDIGSSSSSLQEYVGQQQHNKIQPSTDDDYNEDDYESRRLHLVRTVSSINHHNFDEKFDTISREISRQVTNKEGEFQLRLDEFNLAKILANFVYFAKKQGIVLRKSGITFQDLCVYGVDESFAIAPTVTDLLKGPVGAVQAILSQMKTPPRKILKNLNGFAKPGESVLVLGRPGAGCTTFLKALSGTDFDLYKGVTGDIRYDGLPQKEMLKLFKNDLVYNPELDVHFPHLTVDQTLTFAIACKTPEMRINGVTRDEFINAKKEILATVFGLRHTYHTKVGNDFVRGVSGGERKRVSIAEALACNGSIYCWDNATRGLDASTALEFAQAIRTSTKLLKTTAFVTIYQAGEGIYETFDRVTVLYDGHQVYYGPANKAKKYFEDMGWECPPRQSTAEFLTAITDPIGRFPRAGWENKVPRTAQDFEHYWLNSPQYQELMQEIKDYNDEIDEDETRSKYYQSIQQEKMKGSRTKSPFTISYLEQLKLCFIRSYQRILGDSAYTITLMFASVAQAFVAGSLYYNTPDDVSGAFSRGGVIFFAVLFMSLMGLAEISASFSSRPILMKQKNYTMYHPSADSLSNFVMSIPISIFINTFFVIILYFLSNLARDAGKFFICYLFVIMLHLTMKSMFQAIAAINKSIAGANAMGGILMLASLMYSSYMIQRPSMHPWFKWISYINPVLYAFEAVIASEFHGRKMQCTSQYLTPSGPGYENLGAGEQVCTFIGSVPGQSWVLGDDYLRIAYTYRFSHVWRNLGILFGFLAFFLAIATLGTEYVKPITGGGDKLLFLKGKVPEHITLPSEKKEEDIESGGNSDTTATSNGTLSQGKSEEKAAIVDDGLKAKGVFVWKDVDYVIPYEGKKRQLLQNVSGYCVPGTLTALMGESGAGKTTLLNVLAQRVDFGVITGDMLVNGRPLDTSFSRRTGYVQQQDIHFSEVTVRESLQFAARLRRSNDVSDAEKLEYVEKIIDVLDMRGYADAVVGRLGNGLNVEQRKKLSIGVELVAKPSLLLFLDEPTSGLDSQSAWAIVKLLRDLANAGQSILCTIHQPSATLFEEFDRLLLLKKGGIVTYFGDIGPRSRTILDYFERNGARHCDDKENPAEYILEAIGAGATASTDFDWGEIWAQSPEKVQTDAKRDELINESAKNATDTSATDSPSEKNLTSKYATPYWYQFRHVTHRTSLIFYRDPDYIAAKVFLMTIAGLFIGFTFFGLKHTKTGAQNGMFCAFLSCVIAAPLINQMLEKAGSRDIYEVREKLSNTYHWSLLILPQIIFEVIYMIIGGTIMFVCLYFPTQVSTVASHSGMFYFSQAIFLQTFAVSFGLMVSYVSPDIESASVIVSFLYTFIVSFSGVVQPVNLMPGFWTFMNKVSPYTYFIQNLVSSFLHDRTIRCNAKELSYFNPPSGQTCKEFASAFISRNGGYLVDEGATSNCGYCNFSNADQYLLTIGAKFSYRWRNIGFFCVYIIFNISVCLVLYYFLRYRKVSFNVTGLVNKFKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQC8</accession>
    <name>A0A1D8PQC8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C604290WA</name>
        <name evidence="6" type="ordered locus">orf19.8687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW30347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_707006.2"/>
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    <dbReference type="GeneID" id="3646280"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604290WA"/>
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        <property type="gene designation" value="orf19.8687"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PQC8"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="De-ubiquitination complex subunit, putative"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NTF2-like_dom_sf"/>
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        <property type="entry name" value="NTF2_dom"/>
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        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="59"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="478"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720370.1">
        <property type="nucleotide sequence ID" value="XM_715277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQK0"/>
    <dbReference type="STRING" id="237561.A0A1D8PQK0"/>
    <dbReference type="GeneID" id="3638033"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700410CA"/>
    <dbReference type="CGD" id="CAL0000177839">
        <property type="gene designation" value="orf19.7079"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00410C_A"/>
    <dbReference type="eggNOG" id="ENOG502QSNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQK0"/>
    <dbReference type="OMA" id="LATNWPA"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021895">
        <property type="entry name" value="Bud3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12015">
        <property type="entry name" value="Bud3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="254"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000177839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1147" mass="130757" checksum="C6D5B2CB7611C7C3" modified="2017-01-18" version="1">MKTLHHNEGSKMKKPRLHEITTIPIKQLHSQFDNTENATTKSTTVDEWLDIFPQAAIFTGFDDILFDYVITIVYRKHENISTKSITKFGVSTYENMQLTHRSRFWPSCENLELKYQKSKVRRSLAISNLKNSNKLLNHAGDLPELPNFDETHAGTFASNMNLLSGKSPIEFGKQLLQLGLLQEHSLNSYGMDVVYNNTSSSQEIVDENNKLVFLLGEQLDHLFDPLLEYSPETMNFIYTPQQTQVPQTKLITSIVNELVTVQTNFTSKLVDLLQNLITPLRANVLDSPDGITRVNQVFPPTIDEITRINCILNESLLKAKSINYLEVLRAVANILPYFYKPFVRHEANLKGFYSRLRKFATSSILAIAKKEYSVREIDSIVTGSLLELPRLKLILKRLYDAIESEKLKLKNFENFDEDETMVNKYYTAAMEVIDAFGGHDEQVDLKQRIFTPTGKILTELATNWPAELHYGWLSRKVVGIFQLERSLVVIFNDYLLFLNIIDNNGYMEESHLKKISVSDALMHSLVNEKPLPNLSCFPAMEVSSWCNINEVIATTFVAPTDDNPKDDFIRFLSTSSTGFQSLSAIKQFSKTYHVENNKSKTIIELINKARLLYKCSPFHLFKANDRHLSIYYTAHEDKVYENEISQSPFVLFLNMKLDVPRYFETCPNLQLLLQASFVGDDKIQITGYNKPSQEQINEFVRPNEFSDFLKHKVFNCFNGIFSTYNKITRCLIKGNSAQLKFVIDDNATSRSEATTLDEVKFTPKQTYKHDKSFSEPITVVNVPLENKVDPPLRRRKSICGLLKKHTEDNAVVISEPTLKRDITNTFIPRGDENEYTNTLKPIPTLHRVVQDTTSESTMHYEIESPDDRTTITTSAPSVDASPNFQFPVVNDPVIVPKSASTIKRIATIDSNRIHLEKRSGKIKHGTNYKLLPIGENKSDSSPNWESISISRESSIRTNEPPRKKLDEEVANRVVDVSNLFKTKKIDRYPTKRPDSIPKIIRTTKSANRAFSKTMFAPPPPPRPLKPQQITRDESAVSITVSEMTNEFSQFIDNEFGNEPVPKLSKPSLPHNTSAITLTSSSEDEEFFSPNEEPNHIREPSQSESSEATITSTRQKNFANKQPLLSEDSVTQLCAYLEKSVDFGVFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR30</accession>
    <name>A0A1D8PR30_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C702220CA</name>
        <name evidence="10" type="ordered locus">orf19.13845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721332.2">
        <property type="nucleotide sequence ID" value="XM_716239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR30"/>
    <dbReference type="SMR" id="A0A1D8PR30"/>
    <dbReference type="FunCoup" id="A0A1D8PR30">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PR30"/>
    <dbReference type="GeneID" id="3636989"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702220CA"/>
    <dbReference type="CGD" id="CAL0000176476">
        <property type="gene designation" value="orf19.13845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02220C_A"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PR30"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001991">
        <property type="entry name" value="Uncharacterized protein CaJ7.0258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF563">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE KSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="59"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000176476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="408" mass="46531" checksum="D227D338157E0FC6" modified="2017-01-18" version="1">MGSFSFPKNITTANGFHQEQPNIQIAATTATSGSLVVPELTIEQFSEIKLPAVGIEYNKTSSKPIYEGANGIIFKGSDASHSKVVVLKRVKQKCDQPLHDYIQQVLREFNTMKICNHKNIISIFDLATISDTKELALILPYYPKGDLLNYLSRLRRFKIELSASLKDSIFKQILKGVNYLHGKGIVHRDLKPENFLIDSDGILKISDFGYSLNINNHPLCHEYFKSNPHELYCGTNSFKAPELFTIEHEIKSNRFDFDGYFKDDNTITCFDKSKYLDYWALGIIYFVIFLMKSPWTTANSLDSKNLAYINYCKHYPNSSLKLKEILIELNKKSPSSFTAISNNNNNNNGHNNNPALNLFKSLHYDSRESILGLLNPQPDKRLTPNQLLNTNWLSQVYADPKDLIKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRR6</accession>
    <name>A0A1D8PRR6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR00530WA</name>
        <name evidence="1" type="ordered locus">orf19.7482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Schwartz K."/>
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    </evidence>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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        <scope>GENOME REANNOTATION</scope>
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    <reference evidence="13 14" key="3">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="similarity">
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        <property type="gene designation" value="SMB1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_07510W_A"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTI0"/>
    <dbReference type="OMA" id="HDERIMI"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000198927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW31444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="125" mass="14295" checksum="EE69AAF56531D4F6" modified="2017-01-18" version="1">MSSSSSKLSINKKTKMSDLINFRIKIITIDNRTYLGTLLSFDKHMNLVLSDTEESRITKKSYSQLKKHTPNVELVYDKRNLGLIILRGDQVVSFTIESNAPLTDVKSRLDRPIKKPVSRMKKIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTU4</accession>
    <name>A0A1D8PTU4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_CR08920WA</name>
        <name evidence="11" type="ordered locus">orf19.7288</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716423.1">
        <property type="nucleotide sequence ID" value="XM_711330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTU4"/>
    <dbReference type="SMR" id="A0A1D8PTU4"/>
    <dbReference type="STRING" id="237561.A0A1D8PTU4"/>
    <dbReference type="GeneID" id="3641911"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08920WA"/>
    <dbReference type="CGD" id="CAL0000175310">
        <property type="gene designation" value="orf19.7288"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08920W_A"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTU4"/>
    <dbReference type="OMA" id="WNMFLSK"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="269"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000175310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49349" checksum="E478422327969C27" modified="2017-01-18" version="1">MSVKEDIPAVFLEKVSPRGLEAIQKTKDFVNDYCLPADQIYFEQLSDIPSERWKSVPPVIETLKKKAKELGLWNMFLSKHYKEGPQYTNLEYGLMARYLGRSYTAPEATNTAAPDTGNMELFAKYGTTYQKDRYLKPLLNGEIRSAFLMTEKGVSSSNALNISTSAVKNSNGNYVLNGVKWFASGAGDPRCSVWLVMCKTDNNKQNPYQNHTVLIIDAKKALATGKAKLIRPLQVIGFDDAPHGHCEIQFQDYEVPADEMPNVVMAGVGRGFELIQSRLGPGRIHHCMRAIGAGEFALLRIAHRANHRLIFGKPMNQREGFLSRYGQSKIDIERCLLLVLNAAHKIDISNAKEAQKEIAMAKIETPRTISDILDWGIQVYGAEGMSQDTELARMYAHNRTLRIADGPDEAHLAQLARNEAKKFAKVDDFFANMETQRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTW5</accession>
    <name>A0A1D8PTW5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR09150WA</name>
        <name evidence="1" type="ordered locus">orf19.7311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="APQ12"/>
    </dbReference>
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        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000188307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="214" mass="25084" checksum="4B2AA799D5DF5494" modified="2017-01-18" version="1">MEVKDIFVQIGTIIVFLLEFFFRNSITLIVHAHKNYPDITNVIFFILGVYIIYKILVRTLRSWFNFMIFTIKLIFVLFFVFLVFVIYLRGWETFIYQDVPFLKKSFGHLKAFNDSTTKNGGFGFSNILNFATQFNLNDIKSIFTNVEKNIKENLDESSEYFEYINSQFGNGNGNEPDYDNIQKLVEEGIGYLQENVDLNALRNNIQDILNGHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU69</accession>
    <name>A0A1D8PU69_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">TRX1</name>
        <name evidence="12" type="ordered locus">CAALFM_CR10350CA</name>
        <name evidence="11" type="ordered locus">orf19.7611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thioredoxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW31685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719372.1">
        <property type="nucleotide sequence ID" value="XM_714279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU69"/>
    <dbReference type="SMR" id="A0A1D8PU69"/>
    <dbReference type="FunCoup" id="A0A1D8PU69">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU69"/>
    <dbReference type="GeneID" id="3638950"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10350CA"/>
    <dbReference type="CGD" id="CAL0000180451">
        <property type="gene designation" value="TRX1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_10350C_A"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PU69"/>
    <dbReference type="OMA" id="DFHALWC"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000104">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="8">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="8">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="8">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000180451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="103" mass="11487" checksum="4B78100038A53620" modified="2017-01-18" version="1">MVHVVTEVNEFQTLLKENNLVIVDFFATWCGPCKMIAPLLEKFQNEYSNIKFLKIDVDQLGSLAQEYNVSSMPTLILFKNGEEVNRVIGANPAAIKQALASLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>O13289</accession>
    <accession>A0A1D8PDX2</accession>
    <accession>O42616</accession>
    <accession>Q5AAT2</accession>
    <accession>Q9URJ7</accession>
    <name>CATA_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Peroxisomal catalase</fullName>
            <ecNumber evidence="4">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CAT1</name>
        <name type="synonym">CTA1</name>
        <name type="ordered locus">CAALFM_C106810WA</name>
        <name type="ORF">CaO19.13609</name>
        <name type="ORF">CaO19.6229</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Infect. Immun." volume="66" first="1953" last="1961">
            <title>Cloning and sequencing of a Candida albicans catalase gene and effects of disruption of this gene.</title>
            <authorList>
                <person name="Wysong D.R."/>
                <person name="Christin L."/>
                <person name="Sugar A.M."/>
                <person name="Robbins P.W."/>
                <person name="Diamond R.D."/>
            </authorList>
            <dbReference type="PubMed" id="9573075"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10261 / CBS 2718 / NBRC 1061</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Microbiol. Immunol." volume="52" first="16" last="24">
            <title>Catalase gene disruptant of the human pathogenic yeast Candida albicans is defective in hyphal growth, and a catalase-specific inhibitor can suppress hyphal growth of wild-type cells.</title>
            <authorList>
                <person name="Nakagawa Y."/>
            </authorList>
            <dbReference type="PubMed" id="18352908"/>
            <dbReference type="DOI" id="10.1111/j.1348-0421.2008.00006.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>FC18</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4"/>
    <dbReference type="EMBL" id="U40704">
        <property type="protein sequence ID" value="AAC39448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB006327">
        <property type="protein sequence ID" value="BAA21767.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB006328">
        <property type="protein sequence ID" value="BAA21768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718818.1">
        <property type="nucleotide sequence ID" value="XM_713725.2"/>
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    <dbReference type="AlphaFoldDB" id="O13289"/>
    <dbReference type="SMR" id="O13289"/>
    <dbReference type="BioGRID" id="1222589">
        <property type="interactions" value="1"/>
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    <dbReference type="FunCoup" id="O13289">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="237561.O13289"/>
    <dbReference type="MoonDB" id="O13289">
        <property type="type" value="Curated"/>
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    <dbReference type="MoonProt" id="O13289"/>
    <dbReference type="PeroxiBase" id="5253">
        <property type="entry name" value="CalKat01"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_06810W_A-T">
        <property type="protein sequence ID" value="C1_06810W_A-T-p1"/>
        <property type="gene ID" value="C1_06810W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639495"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106810WA"/>
    <dbReference type="CGD" id="CAL0000188148">
        <property type="gene designation" value="CAT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06810W_A"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="InParanoid" id="O13289"/>
    <dbReference type="OMA" id="KFRWNVF"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="PHI-base" id="PHI:106"/>
    <dbReference type="PHI-base" id="PHI:7209"/>
    <dbReference type="PRO" id="PR:O13289"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CAFA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0036171">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0042743">
        <property type="term" value="P:hydrogen peroxide metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Catalase"/>
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    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
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    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
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    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
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    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0376">Hydrogen peroxide</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000084918" description="Peroxisomal catalase">
        <location>
            <begin position="2"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>F</original>
        <variation>I</variation>
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>T</original>
        <variation>N</variation>
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>K</original>
        <variation>R</variation>
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>L</original>
        <variation>M</variation>
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>K</original>
        <variation>E</variation>
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>R</original>
        <variation>RP</variation>
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>M</original>
        <variation>S</variation>
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39448." evidence="6" ref="1">
        <original>L</original>
        <variation>SF</variation>
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P04040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P15202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18352908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="485" mass="54863" checksum="A9E25AD096390C55" modified="2017-03-15" version="5">MAPTFTNSNGQPIPEPFATQRVGQHGPLLLQDFNLIDSLAHFDRERIPERVVHAKGSGAYGVFEVTDDITDICAAKFLDTVGKKTRIFTRFSTVGGELGSADTARDPRGFATKFYTEEGNLDLVYNNTPVFFIRDPSKFPHFIHTQKRNPETHLKDANMFWDYLTSNEESIHQVMVLFSDRGTPASYREMNGYSGHTYKWSNKKGEWFYVQVHFISDQGIKTLTNEEAGALAGSNPDYAQEDLFKNIAAGNYPSWTAYIQTMTEAEAKEAEFSVFDLTKVWPHKKYPLRRFGKFTLNENPKNYFAEVEQAAFSPAHTVPYMEPSADPVLQSRLFSYADTHRHRLGTNYTQIPVNCPVTGAVFNPHMRDGAMTVNGNLGSHPNYLASDKPVEFKQFSLQEDQEVWNGAATPFHWKATPADFKQAQELWKVLKRYPNQQEHLAHNIAVHAAGADAAIQDRVFAYFGKVSQDLADAIKKEVLELSPRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>P83774</accession>
    <accession>A0A1D8PQU0</accession>
    <accession>Q3MPL4</accession>
    <accession>Q59S46</accession>
    <name>GBLP_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein ASC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Absence of growth suppressor of Cyp1 protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic antigenic protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ASC1</name>
        <name type="ordered locus">CAALFM_C701250WA</name>
        <name type="ORF">CaJ7.0140</name>
        <name type="ORF">CaO19.6906</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proteomics" volume="4" first="3084" last="3106">
            <title>Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Abian J."/>
                <person name="Carrascal M."/>
                <person name="Sanchez M."/>
                <person name="Nombela C."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="15378761"/>
            <dbReference type="DOI" id="10.1002/pmic.200400903"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 47-59; 92-103; 159-173 AND 235-246</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ANTIGENICITY</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
            <tissue>Protoplast</tissue>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="Acta Biochim. Biophys. Sin." volume="42" first="793" last="800">
            <title>Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans.</title>
            <authorList>
                <person name="Liu X."/>
                <person name="Nie X."/>
                <person name="Ding Y."/>
                <person name="Chen J."/>
            </authorList>
            <dbReference type="PubMed" id="20929924"/>
            <dbReference type="DOI" id="10.1093/abbs/gmq093"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4 10">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome (By similarity). Involved in the negative regulation of translation of a specific subset of proteins (By similarity). Plays a role in morphogenesis and pathogenesis (PubMed:20929924).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Causes defects in hyphal development under hypha-inducing conditions and attenuates virulence in a mouse model of systemic infection.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="9">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="BAE44646" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44646.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331027.1">
        <property type="nucleotide sequence ID" value="XM_019475482.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="h=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="h=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="h=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="h=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="h=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="AR/DT=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
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    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="AR/DT=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="AR=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="AR/DT=1-317"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
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    </dbReference>
    <dbReference type="PDB" id="9G30">
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    <dbReference type="PDB" id="9G6J">
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        <property type="resolution" value="2.15 A"/>
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    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
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    <dbReference type="PDBsum" id="8OH6"/>
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    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="P83774"/>
    <dbReference type="EMDB" id="EMD-13737"/>
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    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-16874"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-50990"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="P83774"/>
    <dbReference type="BioGRID" id="1229000">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="FunCoup" id="P83774">
        <property type="interactions" value="1445"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P83774"/>
    <dbReference type="EnsemblFungi" id="C7_01250W_A-T">
        <property type="protein sequence ID" value="C7_01250W_A-T-p1"/>
        <property type="gene ID" value="C7_01250W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645907"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701250WA"/>
    <dbReference type="CGD" id="CAL0000180554">
        <property type="gene designation" value="ASC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01250W_A"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="InParanoid" id="P83774"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="PHI-base" id="PHI:3514"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
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    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
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    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
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        <property type="term" value="F:protein kinase C binding"/>
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        <property type="term" value="F:protein-membrane adaptor activity"/>
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        <property type="term" value="F:ribosome binding"/>
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        <property type="term" value="F:signaling receptor activator activity"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:filamentous growth"/>
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    <dbReference type="GO" id="GO:0036180">
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        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000089300" description="Small ribosomal subunit protein RACK1">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2" evidence="2">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="2">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="2">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5" evidence="2">
        <location>
            <begin position="191"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6" evidence="2">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7" evidence="2">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15378761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20929924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="15378761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="20929924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <sequence length="317" mass="34555" checksum="C31FFE7FFAB153B8" modified="2011-10-19" version="2">MADQEVLVLRGTLEGHNGWVTSLATTPAHPDLLLSGSRDKTLIKWKLTGGEDNQYGIPKKSFKGHSHIVQDVTISADGAYALSASWDRTLRLWDLETGETTQRFVGHKGDVLSVSIAKNLRQIVSASRDKTVKVWNTIGECMATLTGHNDWVSAVRISPSDQSSTVISASWDKTVKSWDLADYSVNADFIGHTGYISCITLSPDGSLCASAGKDGVIILWDLNKNKTLYTLEAKAEVHALAFSPNRYWLAAATTSGIKIFKLQERSLLDELKPEFAVGATAKDPEAISLAWSADGQNLFAGYTDNVIRVWQVMTPSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-01" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MJ1</accession>
    <accession>A0A1D8PKW3</accession>
    <name>MRR2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">multidrug resistance regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRR2</name>
        <name evidence="6" type="synonym">ZCF34</name>
        <name type="ordered locus">CAALFM_C307860CA</name>
        <name type="ORF">CaO19.6182</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E26962" last="E26962">
            <title>In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription factors mutants for mice organ colonization.</title>
            <authorList>
                <person name="Vandeputte P."/>
                <person name="Ischer F."/>
                <person name="Sanglard D."/>
                <person name="Coste A.T."/>
            </authorList>
            <dbReference type="PubMed" id="22073120"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0026962"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Mol. Microbiol." volume="89" first="1003" last="1017">
            <title>Analysis of a fungus-specific transcription factor family, the Candida albicans zinc cluster proteins, by artificial activation.</title>
            <authorList>
                <person name="Schillig R."/>
                <person name="Morschhauser J."/>
            </authorList>
            <dbReference type="PubMed" id="23844834"/>
            <dbReference type="DOI" id="10.1111/mmi.12327"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4 5">Leads to increased drug susceptibility. Displays decreased colonization of mouse kidneys. Shows decreased yeast cell adherence to silicone substrate.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710938.1">
        <property type="nucleotide sequence ID" value="XM_705846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MJ1"/>
    <dbReference type="STRING" id="237561.Q59MJ1"/>
    <dbReference type="EnsemblFungi" id="C3_07860C_A-T">
        <property type="protein sequence ID" value="C3_07860C_A-T-p1"/>
        <property type="gene ID" value="C3_07860C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647468"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307860CA"/>
    <dbReference type="CGD" id="CAL0000180700">
        <property type="gene designation" value="MRR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07860C_A"/>
    <dbReference type="HOGENOM" id="CLU_334333_0_0_1"/>
    <dbReference type="InParanoid" id="Q59MJ1"/>
    <dbReference type="OMA" id="CATFTIH"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001040">
        <property type="term" value="P:positive regulation of cellular response to drug"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000082">
        <property type="entry name" value="Zn(II)2Cys6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000431800" description="multidrug resistance regulator 2">
        <location>
            <begin position="1"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22073120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23844834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="22073120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="23844834"/>
        </source>
    </evidence>
    <sequence length="710" mass="82103" checksum="E449624B2C350E3A" modified="2005-04-26" version="1">MTKRDRTIYSCDACRSRKIKCNRQTPCASCHKSKRDCVYTVSRQRDAQITNRKLDKKTYHQISAIEKKISALEGKKGLLQVETINFNKSFTDQTPLVELQSLFPYLLLSKQDPGCVLVRHHCHHLLEKDPRYFEYSQLLADLSLTKRHHLTARAKALLGEAYIPSPQEGHTIDQLKHVLSLNPNFRFAGNFADPLTSFFSLIPPAWANKQLVDTFFQHIYPVIPIIDETDFNTSINRVLGPQIDGHYINSFPSIGSADDLPFLALFLLVLRISYMYTPGACPVSYDTLRAAETIMKEFDITKTHSLTALQAEIMLRFYKIVAPESYTQSNYVQVSVGVLIQNCYSLALHRDPEYIGEHNPKQQHLRRKIWHLLLRMEVIDSAIFQTILSSNPDASDTKLPQLIDQAPPMEQSIVKHIWRSTDLFVSLRKLVEINSKTSEDTPLETVLELLVEVETKLQAFLATIDSEASTVFYNDLVIFSVNFLLVYMYYSLYLFKGPTPLGNKYLLKSAQILFVDLARTRSTSLFLAYFNLNYIHLVLMITNFLRMRVDCIIHRHLRAQDSSVQDLQCCRYFLKIIFFSHVKELGNYSSSHKYAWQMRKVYLTLAKIMERSSDVLISNDPELVKSAAVDIPVKEINKLLEQYINFKGFTPTTLFDPTDNELIDEMQHENLWNAMENIEYSEKVYSGWIDAIKNVPSNWDWDYWDFLKIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PP0</accession>
    <accession>A0A1D8PRC0</accession>
    <accession>Q3MP11</accession>
    <name>HSM3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>DNA mismatch repair protein HSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSM3</name>
        <name type="ordered locus">CAALFM_C703450CA</name>
        <name type="ORF">CaJ7.0396</name>
        <name type="ORF">CaO19.1331</name>
        <name type="ORF">CaO19.8911</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_706579.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="C7_03450C_A-T-p1"/>
        <property type="gene ID" value="C7_03450C_A"/>
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    <dbReference type="GeneID" id="3646713"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703450CA"/>
    <dbReference type="CGD" id="CAL0000181303">
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    <dbReference type="HOGENOM" id="CLU_577450_0_0_1"/>
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    <dbReference type="OMA" id="YMEQMVL"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Hsm3_like"/>
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        <property type="entry name" value="HSM3_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF18795">
        <property type="entry name" value="HSM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000301756" description="DNA mismatch repair protein HSM3">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="472" mass="55468" checksum="4AF2A1C40A06483D" modified="2005-04-26" version="1">MLDELSYKVLTNLETSYERKQPLGSKLIDRYTLTIDQSTVAQQSYFEQIIPAINRILMNSEAHVIDPDNVLIRLLPEILSHLSFEQILMYYPNDFILHFLFEEKLENVSVICLEVILLNLQEPETLQFLRDNNVISRLLREVYFKKTPISVLNKIERLITVLNGIEEINLLESCLPILKKIRDQGNTVLLSRYLDLVNLLLRYLPEFSPHLYSFTKQEFLKYQDDPLFLILLIQFYVKLVRLKAPVDLSLPLSDILSLYDKFDLLVKNEVVELVAQLSFTQSYTDILFKSQIFKTHNLLEVFEKTENSDIRLLSKANPQVIYELNNSIYPDVLAHLNLFTNNLYFPILLNFMSSTTIFYQLKLHLNNEKLSQLPMDKLFKLLLEMSTHNHSKEHLFNNLPTIMSTNLLETEDLRNNELWNLKLEILQNLLNDDSVPGFEFWHQELTRNYELMTFGRVFRNAAPRVDIIDETA</sequence>
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    <accession>Q59QW5</accession>
    <accession>A0A1D8PQE4</accession>
    <accession>Q7Z883</accession>
    <name>FLO8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator of filamentous growth FLO8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FLO8</name>
        <name type="ordered locus">CAALFM_C604350CA</name>
        <name type="ORF">CaO19.1093</name>
        <name type="ORF">CaO19.8695</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="295" last="307">
            <title>The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans.</title>
            <authorList>
                <person name="Cao F."/>
                <person name="Lane S."/>
                <person name="Raniga P.P."/>
                <person name="Lu Y."/>
                <person name="Zhou Z."/>
                <person name="Ramon K."/>
                <person name="Chen J."/>
                <person name="Liu H."/>
            </authorList>
            <dbReference type="PubMed" id="16267276"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-06-0502"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH EFG1</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Eukaryot. Cell" volume="6" first="2112" last="2121">
            <title>Roles of Candida albicans Sfl1 in hyphal development.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Su C."/>
                <person name="Mao X."/>
                <person name="Cao F."/>
                <person name="Chen J."/>
            </authorList>
            <dbReference type="PubMed" id="17715361"/>
            <dbReference type="DOI" id="10.1128/EC.00199-07"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Eukaryot. Cell" volume="7" first="881" last="893">
            <title>Functional mapping of the Candida albicans Efg1 regulator.</title>
            <authorList>
                <person name="Noffz C.S."/>
                <person name="Liedschulte V."/>
                <person name="Lengeler K."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="18375615"/>
            <dbReference type="DOI" id="10.1128/EC.00033-08"/>
        </citation>
        <scope>INTERACTION WITH EFG1</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Appl. Environ. Microbiol." volume="75" first="3663" last="3672">
            <title>Hypoxic adaptation by Efg1 regulates biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Stichternoth C."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="19346360"/>
            <dbReference type="DOI" id="10.1128/AEM.00098-09"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1780" last="1791">
            <title>Mss11, a transcriptional activator, is required for hyphal development in Candida albicans.</title>
            <authorList>
                <person name="Su C."/>
                <person name="Li Y."/>
                <person name="Lu Y."/>
                <person name="Chen J."/>
            </authorList>
            <dbReference type="PubMed" id="19734367"/>
            <dbReference type="DOI" id="10.1128/EC.00190-09"/>
        </citation>
        <scope>INTERACTION WITH MSS1</scope>
        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="Mol. Biol. Cell" volume="23" first="2692" last="2701">
            <title>The transcription factor Flo8 mediates CO2 sensing in the human fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Du H."/>
                <person name="Guan G."/>
                <person name="Xie J."/>
                <person name="Cottier F."/>
                <person name="Sun Y."/>
                <person name="Jia W."/>
                <person name="Muhlschlegel F.A."/>
                <person name="Huang G."/>
            </authorList>
            <dbReference type="PubMed" id="22621896"/>
            <dbReference type="DOI" id="10.1091/mbc.E12-02-0094"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 6 7 8">Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5 7">Interacts with EFG1 and MSS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the FLO8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712106.2">
        <property type="nucleotide sequence ID" value="XM_707013.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QW5"/>
    <dbReference type="SMR" id="Q59QW5"/>
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    <dbReference type="STRING" id="237561.Q59QW5"/>
    <dbReference type="EnsemblFungi" id="C6_04350C_A-T">
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        <property type="gene ID" value="C6_04350C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646292"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604350CA"/>
    <dbReference type="CGD" id="CAL0000178880">
        <property type="gene designation" value="FLO8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04350C_A"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345808_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QW5"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="PHI-base" id="PHI:5056"/>
    <dbReference type="PRO" id="PR:Q59QW5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036187">
        <property type="term" value="P:cell growth mode switching, budding to filamentous"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:cellular developmental process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036171">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900439">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900743">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900241">
        <property type="term" value="P:positive regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010037">
        <property type="term" value="P:response to carbon dioxide"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093:SF2">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR MSS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000420157" description="Transcriptional regulator of filamentous growth FLO8">
        <location>
            <begin position="1"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="LisH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16267276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17715361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18375615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19346360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="19734367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="22621896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="792" mass="87127" checksum="D27184FEA60ED02E" modified="2017-03-15" version="2">MVPNTTKQVLNSLILDFLVKHQFQDTAKAFSKESPNLPSIPPLMDCSQGFLLEWWQVFFDLFQVRYGDGNSNNNPNNKLYHDYLRVQETQKHLFSQLPLIQQQQQQQHHFQQQQQQQGQQGQPFSQQQQRGIGVASGMQNQQHQFAPQHQGQPQGPGQTPQPPGSATNANFPINMPPNSNPQQQMFPINQQFAQMPNGQNQPSMEQQQRMAMMMKQQAMAAQRQQIPMNGLDPQQQQQMMNAVGGGPGNLNLQQQLFLQQQQQQQQQPKTTFQQQAQNQMNNLRQQAAMVAQQQQQQQQQQQQQGQLQGNLASAMGDSSSKNNSPVGARSNQQSTPQQNAAPAPSPHPSQQGQAQAQHNFQSQQQQQQQQMTKMAGSQGMKKNGQMSNGTSNNSSGRNNNALRDYQNQLMLLERQNKERLEFARNTGNSDSNPLSNGMMFAGQNQYSNSNQNQNQLPPNQQQPTPATFHPPPPPTTANGPQGQFNQKPSPATSNNSPALGNKSSPAMGNKKSKKESNSKKGKKANSNASTTANNKTSGQTTPNMSQPPSAGTEPKQPQPTEQMRQLQDKQQRPGSNTPSMGKKDFQPLTPRSEPISGETTKKKRKSGKLNDNNENSNGNSPKKQAKTNANSKNLDPIIKEEENGVLSLKKESSTSLQDQDLDLNPPLAPTQATAMSNTFNDDPFDVHLLDTQHHHQQNSNNSNHNRGQNLSNGSNNLSVSGPGMGMNNSVFGDSTHAFDINFNIDSLDDIWTTTGPGGDITGTGSGSGGAGGTDDDNFMGMNWAADPIENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SD1</accession>
    <name>Q59SD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">VPS28</name>
        <name evidence="10" type="ordered locus">CAALFM_C208940CA</name>
        <name evidence="9" type="ordered locus">orf19.7844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712596.1">
        <property type="nucleotide sequence ID" value="XM_707503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SD1"/>
    <dbReference type="SMR" id="Q59SD1"/>
    <dbReference type="FunCoup" id="Q59SD1">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SD1"/>
    <dbReference type="GeneID" id="3645794"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208940CA"/>
    <dbReference type="CGD" id="CAL0000187534">
        <property type="gene designation" value="VPS28"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08940C_A"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076417_0_0_1"/>
    <dbReference type="InParanoid" id="Q59SD1"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071469">
        <property type="term" value="P:cellular response to alkaline pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071285">
        <property type="term" value="P:cellular response to lithium ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036177">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="155"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000187534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="248" mass="28226" checksum="C7D64A9A52588DE4" modified="2005-04-26" version="1">MTSSPPEYAPTSTSSFTVSTSDVYNQEVTKSSLIKTPLHKSVYDSLAEIYSILPTLEMVENSYLKDYITDKERYTSTTYRLIHQYQMLIKVFTDDQTKFQLLQKEFLPGLLSDMSNFLDLLLSKFNDSYPHAVSRIKNGLPATIEQINGNQPTSASARLVAEITGNFITCMDAVKLNYKSKEQLHPLLSDLVVNLNELNEELQFTGKSKLVNWLIKINNLQTELTQEEADSFLNDLDIAYKGFYTTLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SN0</accession>
    <accession>A0A1D8PTD4</accession>
    <name>RRP36_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosomal RNA-processing protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RRP36</name>
        <name type="ordered locus">CAALFM_CR07030CA</name>
        <name type="ORF">CaO19.2362</name>
        <name type="ORF">CaO19.9898</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712652.2">
        <property type="nucleotide sequence ID" value="XM_707559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SN0"/>
    <dbReference type="SMR" id="Q59SN0"/>
    <dbReference type="FunCoup" id="Q59SN0">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SN0"/>
    <dbReference type="EnsemblFungi" id="CR_07030C_A-T">
        <property type="protein sequence ID" value="CR_07030C_A-T-p1"/>
        <property type="gene ID" value="CR_07030C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645730"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07030CA"/>
    <dbReference type="CGD" id="CAL0000179560">
        <property type="gene designation" value="orf19.9898"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07030C_A"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_3_0_1"/>
    <dbReference type="InParanoid" id="Q59SN0"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="PRO" id="PR:Q59SN0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000397623" description="rRNA biogenesis protein RRP36">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="281" mass="32954" checksum="F40BDD579FD0FB0F" modified="2017-03-15" version="2">MSRGKTIRPSYYDEEESSQDELSHTLSKGRSNIGSQSDDEEMSKISFGALNRAQSKLNKHNQKHKTQEDNYKSSEEEFFDSDSDSDGPPEETSSKDTKKKKNKHAPSESSSKRPVSRIRDIPGLPSRKQQTLHTDIRFDAAYGKADLAKARKDYAFLDEYRKQEIANMESLLKDKKSKLNDDEREEIKLQLQSLKSRMDTLKNRDLENNILSNYKKQQMESFKEGKVNKPYFLKRSDKRKILQKAKFDSMKPKQREKAMERKRKKRLGKEFRQLEFKPTNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ST6</accession>
    <accession>A0A1D8PJX5</accession>
    <name>PTPA2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein phosphatase 2A activator 2</fullName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptidyl-prolyl cis-trans isomerase PTPA-2</fullName>
            <shortName>PPIase PTPA-2</shortName>
            <shortName>Rotamase PTPA-2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphotyrosyl phosphatase activator 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RRD2</name>
        <name type="ordered locus">CAALFM_C303830WA</name>
        <name type="ORF">CaO19.14195</name>
        <name type="ORF">CaO19.6933</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712734.1">
        <property type="nucleotide sequence ID" value="XM_707641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ST6"/>
    <dbReference type="SMR" id="Q59ST6"/>
    <dbReference type="FunCoup" id="Q59ST6">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ST6"/>
    <dbReference type="EnsemblFungi" id="C3_03830W_A-T">
        <property type="protein sequence ID" value="C3_03830W_A-T-p1"/>
        <property type="gene ID" value="C3_03830W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645630"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303830WA"/>
    <dbReference type="CGD" id="CAL0000193039">
        <property type="gene designation" value="orf19.14195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03830W_A"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="InParanoid" id="Q59ST6"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="PRO" id="PR:Q59ST6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000226109" description="Serine/threonine-protein phosphatase 2A activator 2">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="358" mass="40710" checksum="BBD94A55ADE7A7D9" modified="2005-04-26" version="1">MSYITPTKRIFTPEDLSKWVGSPTYNTVLDFIVELQSSVTGKSNDSSYETSSIIDKLSKLLSKVDNLITLHPAHDSVSRFGKIEFRDFYSDLSSKAEEYISEITATAIQETSAYFIESWGNSTRIDYGSGHELNFICFLLCLKELGQITSADYEGLVLKVFTQYMSIMRKLQKEYWLEPAGSHGVWGLDDYHFLPFLFGAAQLSTHPHMKPKSIHNDELVEMYSTKYMYFECINFINKIKTIPNHQGKLSLRWHSPMLDDISAAKNWDKIREGMVKMYKVEVLGKLPIMQHFMFGSLLKCPEGIPEHTDENGHGENPEDHCGHAHVNTWGDCCGIKIPSGIAASESLKHERKGNIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TC4</accession>
    <name>Q59TC4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">homocitrate synthase</fullName>
            <ecNumber evidence="6">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LYS22</name>
        <name evidence="18" type="ordered locus">CAALFM_C204460WA</name>
        <name evidence="17" type="ordered locus">orf19.11982</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="6"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712932.1">
        <property type="nucleotide sequence ID" value="XM_707839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TC4"/>
    <dbReference type="SMR" id="Q59TC4"/>
    <dbReference type="FunCoup" id="Q59TC4">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59TC4"/>
    <dbReference type="GeneID" id="3645466"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204460WA"/>
    <dbReference type="CGD" id="CAL0000201759">
        <property type="gene designation" value="LYS22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04460W_A"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="InParanoid" id="Q59TC4"/>
    <dbReference type="OMA" id="NMFAHES"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000201759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW27472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="417" mass="46264" checksum="DE23F99CE96019FB" modified="2005-04-26" version="1">MSVASNPYGPNPSDFLSNVNKFEVIESTLREGEQFANAFFTTEKKIEIAKALDDFGVDYIELTSPVASEQSRRDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSQFLRQYSHGKDMNYIAQSAIEVIEFVKSKGIEIRFSSEDSFRSDIVDLLNIYRTVDKIGVNRVGIADTVGCANPRQVYELVKTLKSVVSCDIECHFHNDTGCAIANAYTALEAGAKLIDVSVLGIGERNGITPLGALMARMITADRDYVLSKYKLHKLRDLENLVADAVQINIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILNPNDFGLTRYIHFANRLTGWNAIKSRVDQLNLHLTDDQVKEVTNKIKKLGDVRQLNIDDVDSIIKDFHAEQSTTNTPLLKPVEDDEGPEIKKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UQ3</accession>
    <name>Q59UQ3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mg(2+) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">MNR2</name>
        <name evidence="10" type="ordered locus">CAALFM_C400400WA</name>
        <name evidence="9" type="ordered locus">orf19.13112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713348.1">
        <property type="nucleotide sequence ID" value="XM_708255.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UQ3"/>
    <dbReference type="FunCoup" id="Q59UQ3">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59UQ3"/>
    <dbReference type="GeneID" id="3645017"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400400WA"/>
    <dbReference type="CGD" id="CAL0000200038">
        <property type="gene designation" value="MNR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00400W_A"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_3_1_1"/>
    <dbReference type="InParanoid" id="Q59UQ3"/>
    <dbReference type="OMA" id="DVCFPDY"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
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    </dbReference>
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    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="735"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WI4</accession>
    <name>Q59WI4_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">CAALFM_C110980WA</name>
        <name evidence="2" type="ordered locus">orf19.9853</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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            <begin position="61"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000189564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="177" mass="19774" checksum="220F496D405C656C" modified="2005-04-26" version="1">MVSRKSSSSSNKTSTSTDTMIETIGKPQTVNTSYTSSHDFIPSRPPPPPKIGSASEDTEENTSSSQSSKVSKQDKLQEFSKKLFKKTSSSSLNKKTFYQKLRGKEKKKQRIHGTGVDKNIQTDDITNSLTLDMLDVKKKREKKYRENVTSSLKTFLDSNTSNGAVDSFKDYVENSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q59X87</accession>
    <name>Q59X87_CANAL</name>
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        <recommendedName>
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            <ecNumber evidence="2">2.1.1.22</ecNumber>
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        <name evidence="7" type="ordered locus">CAALFM_CR08040WA</name>
        <name evidence="6" type="ordered locus">orf19.8224</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714219.1">
        <property type="nucleotide sequence ID" value="XM_709126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59X87"/>
    <dbReference type="SMR" id="Q59X87"/>
    <dbReference type="FunCoup" id="Q59X87">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59X87"/>
    <dbReference type="GeneID" id="3644135"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08040WA"/>
    <dbReference type="CGD" id="CAL0000200346">
        <property type="gene designation" value="orf19.8224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08040W_A"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="InParanoid" id="Q59X87"/>
    <dbReference type="OMA" id="KQFAREW"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035498">
        <property type="term" value="P:carnosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000200346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW31489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="395" mass="45371" checksum="85A6ADE701CF0AF8" modified="2005-04-26" version="1">MSQNADEYEALTATLSSFYNFFRHQFEHIIKPRLIKFRAMTEKERALLPWYEAHTGELKQCIEVNRGFTELLSTSIANDWGVAGTSLDWHPAGPREFEITSTTLLQLMREWSDEGQAERDVAFTRIISELEELYPDEPSRQSIRILNPGCGLGRLVMELVIRGFWTQGNEISYHMLLASNFILNHSQFPHSHSIFPFLSRSSHLVKRKYQTRGITIPDVAPFAVLSELKEKTPSIAYEELMSITAGSFLELYGPNKPSDTLNDPAAIELKNSSKDSFDVVVTNFFLDTASNIIEYVRAINHVLKNGGRWINFGPLLWHFEGDYNVSYINREDNVSIPDIKKGLELSREDLLELIKNMGFDFVKHESDIESTYCKDIKSLGSFVFKCEYWVCIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
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    <gene>
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        <name evidence="3" type="ordered locus">orf19.8946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW27963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714540.1">
        <property type="nucleotide sequence ID" value="XM_709447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YG0"/>
    <dbReference type="SMR" id="Q59YG0"/>
    <dbReference type="STRING" id="237561.Q59YG0"/>
    <dbReference type="GeneID" id="3643782"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209850CA"/>
    <dbReference type="CGD" id="CAL0000180468">
        <property type="gene designation" value="orf19.8946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09850C_A"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="InParanoid" id="Q59YG0"/>
    <dbReference type="OMA" id="IFLSGHT"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIOX_N"/>
    </dbReference>
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        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
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        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000180468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47853" checksum="4C00B0DE88B47F53" modified="2005-04-26" version="1">MPVAKDKYNLRPFKEAPLSTSPIKPIELEAVDLSLYKDGAGNLPIRQKLATQIEKSLSTYGFIMVTNHGFPHDKLEFLKSLAQGILEVPLESQKPYLAGALKSDLEDRSISLGAERGAGYKPKKYWSMRNGVEDSIIHYNFNNMQHPSFFQGSGNANNNNQYPPIVQDHLSQVAEYYRYLHNDVLRKLCNLTDIVLELPEGFIWDNYYKVTPNDYENSGGGAGRFMLYEGMDPQDREKVGDTWLRGHSDSGGFTFITSQPILSLQIRDYFTGEWNYVGHTPDGLIVNIGDAMEFITGGYFKSSIHRVVGPPDDQKEFRRLVLIYFCKPKSTCILDPEPLQSPKLNRLGIGKPKEWEKIDFAAWNNEKSRLFGKKNVNDTQSEEPKLVLLYGRLHERWHQAETDFSLEEAEKKFQVIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Z37</accession>
    <name>Q59Z37_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C207080CA</name>
        <name evidence="2" type="ordered locus">orf19.9803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714853.1">
        <property type="nucleotide sequence ID" value="XM_709760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Z37"/>
    <dbReference type="SMR" id="Q59Z37"/>
    <dbReference type="GeneID" id="3643502"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207080CA"/>
    <dbReference type="CGD" id="CAL0000192507">
        <property type="gene designation" value="orf19.9803"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07080C_A"/>
    <dbReference type="eggNOG" id="ENOG502S7T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105491_0_0_1"/>
    <dbReference type="InParanoid" id="Q59Z37"/>
    <dbReference type="OMA" id="FESETGP"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="Gene3D" id="3.10.580.10">
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        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00571">
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        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="179" mass="20508" checksum="E42ECC500C73612B" modified="2005-04-26" version="1">MSETPLLFQTRDYRGATIEDLNIPLAVSINPTTSIYEAIGIAFENEFTYLPVIHERTKRLLGVINIEELKSNGDKLKRSILAPIVKSYMIWFNQSAKRKYEQENKEVLSSNRTAPKTTILKPRGKRYEVLTPMTPLEKLAEFFNSGNYFAIVTNGHGDFVYGVVTPQDLMKYEQSRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZH5</accession>
    <name>Q59ZH5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C205130WA</name>
        <name evidence="4" type="ordered locus">orf19.11028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714903.1">
        <property type="nucleotide sequence ID" value="XM_709810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZH5"/>
    <dbReference type="SMR" id="Q59ZH5"/>
    <dbReference type="FunCoup" id="Q59ZH5">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZH5"/>
    <dbReference type="GeneID" id="3643458"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205130WA"/>
    <dbReference type="CGD" id="CAL0000187542">
        <property type="gene designation" value="orf19.11028"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C2_05130W_A"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_026673_29_2_1"/>
    <dbReference type="InParanoid" id="Q59ZH5"/>
    <dbReference type="OMA" id="YNNREAS"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000187542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40897" checksum="8E7E1F43DEF7B699" modified="2005-04-26" version="1">MSLPSVATQIVLKNHPAGFINPEFNKLDSTFAVKHASFPKELKEGEVIVKTLYLSNDPTQRSWIRSKLEKRRHYAKPIEEGSPMRSLGLGQIVQSNSSRFKPGDIVYGIILWGDYSVLEDTSLYNSIDTSLGLPLEYYLSVLGMTSLTAFFGLTEAGDLKQYLNSPPGKGPIVCVSAASGATGSVVVQIAKNLLGASKVIGISGSSEKCQWVEKLGADICVNYKDPNYQDQIEKFLGDEFIDTYFDNVGGDILSFVLTKVKKFGNVVACGSIAGYNNREASKVSNWGEITVNSLTVRGFIVTDYQEHFPKAIGILTDAVKAGKIRTDGAYHVENLHGHDLIHRLENIPKIWNKLFEDNKPNGKMITKVALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0I7</accession>
    <name>Q5A0I7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C202820CA</name>
        <name evidence="4" type="ordered locus">orf19.13246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715365.1">
        <property type="nucleotide sequence ID" value="XM_710272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0I7"/>
    <dbReference type="SMR" id="Q5A0I7"/>
    <dbReference type="STRING" id="237561.Q5A0I7"/>
    <dbReference type="ESTHER" id="canal-q5a0i7">
        <property type="family name" value="ABHD11-Acetyl_transferase"/>
    </dbReference>
    <dbReference type="GeneID" id="3643027"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202820CA"/>
    <dbReference type="CGD" id="CAL0000180924">
        <property type="gene designation" value="orf19.13246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02820C_A"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_53_0_1"/>
    <dbReference type="InParanoid" id="Q5A0I7"/>
    <dbReference type="OMA" id="LITMHGL"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="69"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000180924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="353" mass="41619" checksum="55199A46527C5BBA" modified="2005-04-26" version="1">MFSKSGVNRVRQLILKRYTHQTSQTSQTNVLTPTFSVDQIRDLPYVDHVDLVWKQLLPYKVKINKRKTPILFLHGLFGSISSFNSIGRSLSAVVKHPVYAVDLRNHGDSPRALPHTYTIMARDIHNFIKQRKWDECILVGHSMGAKVAMMVSLLYPSLVSKLVVVDNTPHSRPLNHQFYKDLLGMCEVEVNGHQYKTANKKTVGKISQINRFLTQYEEDHKMRQILTGNLMTCLKHFKNRKDINHEKEVFKMPVMNFYKYDILRTLGGWPQLPQVQKFDKPVYVMYGNQSEFVAPQFHKEFYRYFTNVKFQDFDSGHWVAMEQPRQFLKKLAKFIDYDEYCKFKPNKVRYVKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0M4</accession>
    <accession>A0A1D8PGT9</accession>
    <accession>O13430</accession>
    <accession>Q9P4S4</accession>
    <name>EF2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor 2</fullName>
            <shortName>EF-2</shortName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EFT2</name>
        <name type="ordered locus">CAALFM_C203100WA</name>
        <name type="ORF">CaO19.13210</name>
        <name type="ORF">CaO19.5788</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Capa L."/>
                <person name="Mendoza A."/>
                <person name="Serramia M.J."/>
                <person name="Garcia-Bustos J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10261 / CBS 2718 / NBRC 1061</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proteomics" volume="4" first="3084" last="3106">
            <title>Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Abian J."/>
                <person name="Carrascal M."/>
                <person name="Sanchez M."/>
                <person name="Nombela C."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="15378761"/>
            <dbReference type="DOI" id="10.1002/pmic.200400903"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 559-564; 581-585 AND 675-682</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ANTIGENICITY</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
            <tissue>Protoplast</tissue>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Has antigenic properties.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="Y09664">
        <property type="protein sequence ID" value="CAA70857.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330758.1">
        <property type="nucleotide sequence ID" value="XM_019475213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0M4"/>
    <dbReference type="SMR" id="Q5A0M4"/>
    <dbReference type="BioGRID" id="1226092">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A0M4">
        <property type="interactions" value="1287"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0M4"/>
    <dbReference type="MoonProt" id="Q5A0M4"/>
    <dbReference type="EnsemblFungi" id="C2_03100W_A-T">
        <property type="protein sequence ID" value="C2_03100W_A-T-p1"/>
        <property type="gene ID" value="C2_03100W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642998"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203100WA"/>
    <dbReference type="CGD" id="CAL0000189676">
        <property type="gene designation" value="EFT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03100W_A"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="Q5A0M4"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="PRO" id="PR:Q5A0M4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="EFG_V-like"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
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        <property type="entry name" value="G_TR_1"/>
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        <property type="entry name" value="G_TR_2"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091015" description="Elongation factor 2">
        <location>
            <begin position="1"/>
            <end position="842"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="346"/>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
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        <ligand>
            <name>GTP</name>
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        <location>
            <begin position="213"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="1">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15378761"/>
        </source>
    </evidence>
    <sequence length="842" mass="93354" checksum="5C8C740109A23189" modified="2011-10-19" version="2">MVAFTIEQIRGLMDKVTNVRNMSVIAHVDHGKSTLSDSLVQKAGIISAAKAGDARFMDTRKDEQERGITIKSTAISLYASMTDEDVKDIKQKTDGNSFLVNLIDSPGHVDFSSEVTAALRVTDGALVVVDTVEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQTTKEDLYQTFARTVESVNVIISTYCDPVLGDVQVYPQKGTVAFASGLHGWAFTVRQFANKYSKKFGVDKEKMMERLWGDSYFNPKTKKWTNKDKDADGKPLERAFNMFILDPIFRLFAAIMNFKKDEIPVLLEKLEIQLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAETLYEGPSDDPFCTAIRNCDPNADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYQVGKKEDLFLKSIQRTVLMMGRSVEQIDDCPAGNIIGLVGIDQFLLKSGTITTNEAAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLENDHAGVPLRISPPVVSYRETVEGESSMVALSKSPNKHNRIYVKAQPIDEEVSLDIENGVINPRDDFKARARILADKHGWDVVDARKIWCFGPDGNGPNLVVDQTKAVQYLNEIKDSVVAAFQWATKEGPIFGENCRSVRVNILDVTLHADAIHRGGGQIIPTMRRVTYASMLLAEPAIQEPVFLVEIQCPENAIGGIYSVLNKKRGQVISEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQLIFDHWQVMSGDVTDENSKPGAIVKEKRVRAGLKPEVPEYTEYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0Z9</accession>
    <name>Q5A0Z9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">PDA1</name>
        <name evidence="8" type="ordered locus">CAALFM_C407110CA</name>
        <name evidence="7" type="ordered locus">orf19.10608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715406.1">
        <property type="nucleotide sequence ID" value="XM_710313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0Z9"/>
    <dbReference type="SMR" id="Q5A0Z9"/>
    <dbReference type="FunCoup" id="Q5A0Z9">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0Z9"/>
    <dbReference type="GeneID" id="3642902"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407110CA"/>
    <dbReference type="CGD" id="CAL0000181135">
        <property type="gene designation" value="PDA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07110C_A"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="InParanoid" id="Q5A0Z9"/>
    <dbReference type="OMA" id="SKRDPIM"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
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        <location>
            <begin position="67"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000181135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="401" mass="44175" checksum="48368261F23F35B5" modified="2005-04-26" version="1">MYRATATSRQLVGTTANILVAKRSMAKAASDLVTIELPASSYEGYNLEVPALSFETEKETLLKMYKDMIIIRRMEMAADALYKSKKIRGFCHLSVGQEAIAVGIENAITPTDTVITSYRCHGFAFMRGASVKSVLAELMGRRSGIANGKGGSMHMFTNGFYGGNGIVGAQVPLGAGLAFSHKYKNDKAVTFDLYGDGASNQGQVFEAYNMAKLWNLPVIFACENNKYGMGTSAARSSAMTEYYKRGQYIPGLKINGMDVLATYQASKFAKDWASQGNGPLVLEYETYRYGGHSMSDPGTTYRTREEVQHMRSRNDPIAGLKAVLLEKEIASEDEIKSYDKAARKYVDEQVAAAEADAPPEAKMDILFEDVYVPGSEIPVLRGRISDDSWDFKNKTFLNKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A346</accession>
    <name>Q5A346_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tsr1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">TSR1</name>
        <name evidence="8" type="ordered locus">CAALFM_CR08490WA</name>
        <name evidence="7" type="ordered locus">orf19.13775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716255.1">
        <property type="nucleotide sequence ID" value="XM_711162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A346"/>
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        <property type="interactions" value="1083"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A346"/>
    <dbReference type="GeneID" id="3642135"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08490WA"/>
    <dbReference type="CGD" id="CAL0000183541">
        <property type="gene designation" value="TSR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08490W_A"/>
    <dbReference type="eggNOG" id="KOG1980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A346"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000461">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="83"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000183541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="842" mass="94471" checksum="262644559F9F00BA" modified="2005-04-26" version="1">MANSHRNTLKHDHKPFKSKHATKGQIKARIKGKVEKSSNSSGGSKSSKVVSKLERKNLSKQQRDNKILETKLTKKLFEGNSGAEKIVTIITLTNDLSAVDIANRLFNEQEDTSNESITRFDFGYPSVTNINIAKFKTNLKVIIPKQNNMISILDAAQVSDFVLLGISATEEIGENSFGETVLRALIAQGISTTIGVLPNIVSAYPKRNLQLDVKQSLQSFYHHFFPSRDGSSNRGSGTDSGGNKLYSLELDSDNSNCLRIICQKFPQSITWRDSRGWLVADKVEIFNPNGMPVENQQQMMVVEGMVRGVGFNVNRLVHLPGLGDFQLHKLEKLARKARGNSSRNHRGGMDIDTGNDGDAEETFLPNEQQESLDELNPDEGIDMGTMEDDDDFLNNDNFGVRSEGKIYFDNGNSNGTSSSSTGKKLVPRGTSEYQGRWFVDDVLDEDASDLEEQREGEGEEEEDANIVDDDMMVEDNMEADDITDSIHDSEMMHVDLSPEEESRQLEEYRSLAKDDLEFPDEIELHPNESAIERLKGFRGVKSLGNCDWDYDEYDPEAPSILKRLFQVSNYKATKNKVNKQFIKQTEITAGNRVRLYIIIPPGASNNVSSVIGSCSSVPFPVYELLEHEHKLGVCNFSFEAWQDYEKPIINKEQIIVQYGPRRQIIQPLYNQANNNPNNVHKLENFVHHNQGGGGAIIATAITPVLFTNSPTLFFKIHPDADDSSNSNGGSVEFVGKGTYLGSDAKRIMVQRVVLTGHPIKIHKRVVTIRYMFFNREDINYFKAVSLFTKNSGRVGFIKESLGTHGYFKANFDGKLTSQDVVAMSLYKRSWPEVSTAWNKFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4X7</accession>
    <name>Q5A4X7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAALFM_C500260WA</name>
        <name evidence="18" type="ordered locus">orf19.8584</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716807.1">
        <property type="nucleotide sequence ID" value="XM_711714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4X7"/>
    <dbReference type="SMR" id="Q5A4X7"/>
    <dbReference type="FunCoup" id="Q5A4X7">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4X7"/>
    <dbReference type="GeneID" id="3641561"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500260WA"/>
    <dbReference type="CGD" id="CAL0000189135">
        <property type="gene designation" value="orf19.8584"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00260W_A"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="InParanoid" id="Q5A4X7"/>
    <dbReference type="OMA" id="CKMKKHR"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000051">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000189135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW29472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="404" mass="44466" checksum="3EFDBF8E241327C9" modified="2005-04-26" version="1">MRKCKIFVGSSHPELGQLVCDRLGVEPAPCTLKKFSNGETSVQIGVSVRDEDVYIIQSGSPHINDHIMELLILISACRGGSANKITAVIPQFPYSKQSKMKKHRGAITARMLANLLVMAGADHVVSMDLHASQMQGFFSKPVDNLFGAPTLARWIRHHIPDWENAVVVSKNPGGTKRVTALADSLKINFAMIHTDRRRTQDEYAKKKELKQAQIIEEGEDNIVSELQTARVVQGHVVDDDYQANGTSEHLAKEGILDSDVLGGTYDATGSDDEDETTTSSEEKLITLVGDVKDKVAIILDDMIDKPNSFIAAAEHLRLNCGAKAVYVVGTHGVFNDKCLKDLTDSKCIDKIVVTNTYPISKEQIEKHKDKLVVIDVSPIFAECIRRDHFGESISVLFDSLSSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6P1</accession>
    <name>Q5A6P1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RON1</name>
        <name evidence="5" type="ordered locus">CAALFM_CR04250WA</name>
        <name evidence="4" type="ordered locus">orf19.8144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717376.1">
        <property type="nucleotide sequence ID" value="XM_712283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6P1"/>
    <dbReference type="SMR" id="Q5A6P1"/>
    <dbReference type="STRING" id="237561.Q5A6P1"/>
    <dbReference type="GeneID" id="3640990"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04250WA"/>
    <dbReference type="CGD" id="CAL0000194121">
        <property type="gene designation" value="RON1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04250W_A"/>
    <dbReference type="HOGENOM" id="CLU_039323_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A6P1"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043610">
        <property type="term" value="P:regulation of carbohydrate utilization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000005">
        <property type="entry name" value="Meiosis-specific transcription factor NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="3">
        <location>
            <begin position="9"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="9"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000194121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="490" mass="55663" checksum="BC02D4E05E3D3667" modified="2005-04-26" version="1">MTNLSFHRKQKSKNKACNLDFKSDSVLELLNSKSKVAPRSGLQFKVGPPFQDTIQVSQLFIKESHQKIVPVLNARIDRGFDLTNNEWVGYKRNYFSVVASFSFEEYEINKSILPKNGFFIVSGEKEYQVKQFAIRLVSKSVQDNTEISLIQHTAKRDRGPISEPPIVPVITGSIPSHIVVKEGSNIRKISKIRQFDSLFFQDYKTLPILQSGSILNNYDKNKDYVKVVKYERIQFSSAINCKKQSITEKKRFILQIQLLAALSGENTYAIIAISNTPSLIIRGRSPSSYNSRGEGIEQSQNTECEEDVQSFLTTTANDKYTVYPESRDLGELSIMDNLYKNKENFEILKSYDSMDSYTINTIMSSEATASNWLDCSKLDFEEHSKLELQGGFPDVNIYSSPGPTPGLLEQESDPESLEPSYFLMKARTKYLQNPDNMIVGCQKTFSNEFFNHRKQAANLAYKIFEDGVEDDESDLDIVSKYVTPSDVMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A933</accession>
    <name>Q5A933_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-binding SDF ubiquitin ligase complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C101130WA</name>
        <name evidence="7" type="ordered locus">orf19.10811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <taxon>Saccharomycotina</taxon>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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                <person name="Hogues H."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000128">
        <property type="term" value="P:flocculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060257">
        <property type="term" value="P:negative regulation of flocculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051223">
        <property type="term" value="P:regulation of protein transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000280571" description="Chitin synthase export chaperone">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="310" mass="34709" checksum="CDB07F2D43991D18" modified="2005-04-26" version="1">MSFGSFDHICNKTALPLCSVVGAVNQSAFFQRGIVPDCYARSVELANTMIFQIGNAFVHFGGLIILLIIIFNVRAKYTAIGRKEMLFFLYLAIGLIVSSLIVDCGVSPPSSTSYAYFVAVQIGLSSALCICLLYNGFLCFQFWEDGTSRSMWILRVGCFAWFAVNFIVCIITFKHWDTALDYRKTTTLFIFAYVLNAVILAVYVVSQIILVVFALESYWSLGAILLGVFFFVAGQVLTYVFSDKICRGASHYVDGLFFGSACNVFTFMMIYKFWDMITSDDLEFSVANVEQPINEFGVGADDEKRSSMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAW5</accession>
    <name>Q5AAW5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA exonuclease 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C107090CA</name>
        <name evidence="11" type="ordered locus">orf19.13575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718786.1">
        <property type="nucleotide sequence ID" value="XM_713693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AAW5"/>
    <dbReference type="SMR" id="Q5AAW5"/>
    <dbReference type="FunCoup" id="Q5AAW5">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AAW5"/>
    <dbReference type="GeneID" id="3639488"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107090CA"/>
    <dbReference type="CGD" id="CAL0000194430">
        <property type="gene designation" value="orf19.13575"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07090C_A"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008679_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AAW5"/>
    <dbReference type="OMA" id="HKAGPPF"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031125">
        <property type="term" value="P:rRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="10">
        <location>
            <begin position="337"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000194430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="744" mass="84419" checksum="ADFF1B68D1237A17" modified="2005-04-26" version="1">MKSEIEIELGADDPLSKSTARLSICQADMEEETEGNQNPRLQVRELLQREKESIQRRDSAVSLNSFLEEDEENDQQQSQSQQQHLSPKKKSRSKKAAEKRRRSSAHSFSIAQQQPPLKREKVHKRKLKKRLQPPNIELLLDKSEENSNKDSELKRFPFRNLRSLILKVFNVPGTNNLKWCNIENSEKIPTVCVCLVPGLQLEENLAETADNGLQSSKEKSKQQCAISNLKRIDQLSFIFDNFTNFIKSSSPGSKDSIFSSLQTLLNVPLTKNEKNSLLRKSKATKITIKDLLLTEQQLKTYNYPTTLVDSTWKATKDLYNTDSNNNEKSDSETRKSRIYALDCEFCKAGAKQVLTRISLLDFEAKVVMDELVKPKEEITDYVTKYSGITEELLRDVTTTIEDIQNLFVNTVSQQDILIGHSLESDLNVMKIKHDNIVDTSIIYEHNRGPPSKPSLKSLAEKHLNRQIQAGEGQGLGHSSIEDAKACLDLVKLKIIEGKLFGVNVGEVSIFQRLSENPNYNAGGEVNPSSDTDGNNTFKSLLVSYGQTREYDINPDEKYDLTKINVTNDDEAVENFVKEIHSKNFAVINLRDSEFNNKWNTPPDYYKGDLDYNQMESYKRTNQRLEKIYQSLPDHSLLICYSQSGDPREMFKLQGVRRNFQKCEKEGIVDVTKLPEEESWTFTKSEKLLEQTSLARESLMFIKIKPSSDTGSYSINNLSTETITSVTPEISGGGGGSSSSNKDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABB8</accession>
    <name>Q5ABB8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HSP70/90 family co-chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">CNS1</name>
        <name evidence="8" type="ordered locus">CAALFM_C100560WA</name>
        <name evidence="7" type="ordered locus">orf19.13473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719014.1">
        <property type="nucleotide sequence ID" value="XM_713921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABB8"/>
    <dbReference type="SMR" id="Q5ABB8"/>
    <dbReference type="FunCoup" id="Q5ABB8">
        <property type="interactions" value="1290"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABB8"/>
    <dbReference type="GeneID" id="3639365"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100560WA"/>
    <dbReference type="CGD" id="CAL0000195791">
        <property type="gene designation" value="CNS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00560W_A"/>
    <dbReference type="eggNOG" id="KOG0551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040446_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ABB8"/>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000560">
        <property type="entry name" value="CNS1p TPR-containing co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="263"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000195791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW25754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="390" mass="45168" checksum="8E38D93754F7D15E" modified="2005-04-26" version="1">MSKIEPVTEKEEEYVSEWDRRRYVPKAGEPELPPQLSEFSNKTTDEVIEELNRLPFFMTKLDETDGDGGENVNLEALKSLAYEGDPDEIASNFKNQGNNCYKFKKYKDAIIFYTKGLEVNCDVDAINSALYLNRAACNLELKNYRRCIEDCKKVLMLDEKNIKACFRSGKAFFAIEKYDEAIKVLEYGLNIEPENKDLQKLLQQVQKRQETLAQIKAKKAQEEEQERLKNIVLENSIKLRHIEIVKSSSPPEVLKTAKIRLEDPKDYQSQLIFPAMILYPTTDEFDFIAEISELTTPLELLEMVLNRPREWFDDPKHKDFNVKKLECFMETESGGLIKVGKKIEVNNALMNEKPKAPLFDNALRLYVVPKLDVAKWTSEWNKETALAARK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD49</accession>
    <accession>A0A1D8PG92</accession>
    <accession>Q5ADH9</accession>
    <name>DPH4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>J protein type 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">JJJ3</name>
        <name type="synonym">DPH4</name>
        <name type="ordered locus">CAALFM_C201060CA</name>
        <name type="ORF">CaO19.2018</name>
        <name type="ORF">CaO19.9568</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719467.2">
        <property type="nucleotide sequence ID" value="XM_714374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD49"/>
    <dbReference type="SMR" id="Q5AD49"/>
    <dbReference type="FunCoup" id="Q5AD49">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AD49"/>
    <dbReference type="EnsemblFungi" id="C2_01060C_A-T">
        <property type="protein sequence ID" value="C2_01060C_A-T-p1"/>
        <property type="gene ID" value="C2_01060C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638835"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201060CA"/>
    <dbReference type="CGD" id="CAL0000175524">
        <property type="gene designation" value="orf19.9568"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01060C_A"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_7_0_1"/>
    <dbReference type="InParanoid" id="Q5AD49"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="PRO" id="PR:Q5AD49"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000071145" description="Diphthamide biosynthesis protein 4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="3">
        <location>
            <begin position="82"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="149" mass="16768" checksum="89FF73BF59A0602F" modified="2017-03-15" version="2">MISYYEVLGVTPEASIPELKQAYKSKLLTSHPDKIDNSSAQVDIPLIKQAFATLVDPTSRKQYDKQLIESSKLKGFNINGGGLDIYSLDDFEFDNDEWSKSCPRCTAHKSICLTETDLEKGTPDKDGGFDIIVQCNSCSLWIQVKYYEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-04-09" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADL8</accession>
    <accession>A0A1D8PKL6</accession>
    <name>TRY6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator of yeast form adherence 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TRY6</name>
        <name type="ordered locus">CAALFM_C306790WA</name>
        <name type="ORF">CaO19.14116</name>
        <name type="ORF">CaO19.6824</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="62" first="100" last="119">
            <title>The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans.</title>
            <authorList>
                <person name="Bennett R.J."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="16987174"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05367.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Eukaryot. Cell" volume="4" first="1562" last="1573">
            <title>Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Murillo L.A."/>
                <person name="Newport G."/>
                <person name="Lan C.Y."/>
                <person name="Habelitz S."/>
                <person name="Dungan J."/>
                <person name="Agabian N.M."/>
            </authorList>
            <dbReference type="PubMed" id="16151249"/>
            <dbReference type="DOI" id="10.1128/EC.4.9.1562-1573.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor required for yeast cell adherence to silicone substrate.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5">Expression is induced in biofilm and repressed by alpha pheromone.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Decreases cell adherence to silicone substrate.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword id="KW-1185">Reference proteome</keyword>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rit1_N"/>
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    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="340"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="437" mass="49189" checksum="E3AFAF93B751867C" modified="2005-04-26" version="1">MQQPIFNINNDINEINKDLKKSSLSLKNRLQSIVHDQYFVRTVHRSLSYPLIANERCGLWYVPLNDRLDTCYFKSTDGHTNVWSFSLRRLNLHLLPIILEHGGVVIVDSTRRGKLMPDALSKTIPIWCAVLNSVIFGTGDWLRTPSSMVSKSEHNSIEKLIPSFVASVKQMKLLEGFKLDKPLIPSWYYPGASLNSNLDESVYNICCISASRKVDVHKRIDIRTGNGTISCDYIQGSADDHELWVPSSLCNGKFGADVFWSMAGDLLEDGYIKCGETELIEKINSLYNPVDGSMEIFKLGETGISIGKLEGDAKFSQVNTNIILFHEEYTITDIPKDRQILQYSISSNKKGSNKFREILPKIKIDLPCTILCDTGRDLSVGMALVLLCLNFDLNWCPTTTPPTVTKTLIKQHLSKISQICKVNPSRSTLQSVNTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEV7</accession>
    <name>Q5AEV7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C302890CA</name>
        <name evidence="5" type="ordered locus">CAALFM_C303000WA</name>
        <name evidence="3" type="ordered locus">orf19.7912</name>
        <name evidence="2" type="ordered locus">orf19.7928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Candida Genome Database"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">SC5314</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">SC5314</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719978.1">
        <property type="nucleotide sequence ID" value="XM_714885.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719992.1">
        <property type="nucleotide sequence ID" value="XM_714899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEV7"/>
    <dbReference type="STRING" id="237561.Q5AEV7"/>
    <dbReference type="GeneID" id="3638336"/>
    <dbReference type="GeneID" id="3638389"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302890CA"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303000WA"/>
    <dbReference type="CGD" id="CAL0000186143">
        <property type="gene designation" value="orf19.7912"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000175697">
        <property type="gene designation" value="orf19.7928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02890C_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03000W_A"/>
    <dbReference type="eggNOG" id="ENOG502RQEU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1875168_0_0_1"/>
    <dbReference type="OMA" id="VKLICCG"/>
    <dbReference type="OrthoDB" id="4008099at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000175697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000186143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="136" mass="15384" checksum="EE3F32DB672D834D" modified="2005-04-26" version="1">MQRSWLQLISIVSRNIADDLKNNILNRPPILLILNPDSFEPPFTNGFDEYFNVTSTALLGQYSNSKAANYAIVALSIVLAGLDIIYSIIRLSISTMLMGAFLGSLLFFGLWFVVTASRRWKLVVLLFQNNDYNVLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AF56</accession>
    <accession>A0A1D8PLK2</accession>
    <name>ADR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator ADR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ADR1</name>
        <name type="ordered locus">CAALFM_C402500CA</name>
        <name type="ORF">CaO19.10266</name>
        <name type="ORF">CaO19.2752</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="2668" last="2678">
            <title>Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.</title>
            <authorList>
                <person name="Uhl M.A."/>
                <person name="Biery M."/>
                <person name="Craig N."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="12773383"/>
            <dbReference type="DOI" id="10.1093/emboj/cdg256"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1604" last="1614">
            <title>The transcription factor homolog CTF1 regulates {beta}-oxidation in Candida albicans.</title>
            <authorList>
                <person name="Ramirez M.A."/>
                <person name="Lorenz M.C."/>
            </authorList>
            <dbReference type="PubMed" id="19700635"/>
            <dbReference type="DOI" id="10.1128/EC.00206-09"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in the regulation of hyphal growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is increased in biofilm.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Affects filamentous growth.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">Targets a different set of genes than S.cerevisiae ADR1.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720502.2">
        <property type="nucleotide sequence ID" value="XM_715409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AF56"/>
    <dbReference type="SMR" id="Q5AF56"/>
    <dbReference type="BioGRID" id="1220960">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AF56">
        <property type="interactions" value="888"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AF56"/>
    <dbReference type="EnsemblFungi" id="C4_02500C_A-T">
        <property type="protein sequence ID" value="C4_02500C_A-T-p1"/>
        <property type="gene ID" value="C4_02500C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637866"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402500CA"/>
    <dbReference type="CGD" id="CAL0000189036">
        <property type="gene designation" value="ADR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02500C_A"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007571_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AF56"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="PRO" id="PR:Q5AF56"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF28">
        <property type="entry name" value="REGULATORY PROTEIN ADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000426051" description="Transcriptional regulator ADR1">
        <location>
            <begin position="1"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1132"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1338"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1338"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12773383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="12773383"/>
        </source>
    </evidence>
    <sequence length="1418" mass="160414" checksum="3B44866A0B841777" modified="2017-05-10" version="2">MISPTHQSQYLNYFVNPVLMTESGDIIDSVTGTTTTTANMSNTTIDAPTPASTTKNYKHKKQNTNTGTSMSPSNSINSTNNNAAAAAATTTTSKKSKDIPLELTAFGTTPSGKPRLFVCQVCTRAFARLEHLRRHERSHTKEKPFSCGVCQRKFSRRDLLLRHAQKLHAGCTDAITRLRRKSIKKSQDGDDDDDDDDDDEEMANSEDENDHDESGNASTKNGKKDKKDPPPEFNLNLFNSKQKPTKANTTKSKVAKLSTTTSRKNSTNPTRKNSSSLHKQVLDQRQKAAVNTKIVSSTKIVSGTNSGVSITPTRSRRGASFSAQSGANYAINIPEFNDIYPQSDNVEFSTPQFLPSSLDNEMTWLNNIPNIPGLSDSVSAANLMRQNSITNSADHVTPPVNVSQHGSFSHQSTFSATDMGQTRSESVNSLNTPFDGSYMMPTVTISNQEIQNGVAAHHHHQQQQQHQQHNHQHQPNQSSLGLSRNDMLSEDHYGYSFYDIPENILNFPMDSISTTSNAMSSGPIQNFKPLSPITQEIEHEITPRIDGRIGDFQNNNNTNDNPIHQNINYDLNFLHTIDDIGQDVISKFMPGGYSFYGDNNVSATSSANDYNSPNNIVSPSQQNNQFALHNQSSHPSGASPHLNQAMMNKMRLHNYSSNKLFTNHIRHMINKALGKYPISGIMTPTIPSNEKLEFYLSVFIQSFLAHLPFIHPSKLNEYEIMAMTGNEDINNESARVCLPLLTATMGALLANNKNDAEHLYEASRRTIHIYLESRKTNSTNDKNYKNGKDKSSSGNPLWLLQSLMLSVLYGLFSDNENNVYIVIRQLNALNSLVKTSIKNKGPIFFSNNGEDEELYNKLNSHDNGTSLFSNNLNDEMRYKNNINMQSQTRIVFIIYRLTNFLLMMYNVPLTFSINDINQLAVTSKDEETLWNFKNYQEFQEFSHKNNKTLDDYLNHKNEPIIFRELLLTVIKFGISDSNISPEIEKKVTHQLQNLCKYGFNCLVHGIYEIKQYQEMKEVDTFKVLDYLTKFYPTNDGLGFNCFRLPANKDLEKIDYALLVDFTKISSIIDLKLLKEQSWLKNYQDLTQNYHRLLDAHSTGNPLNSINDYDYLKLADCCISVLKLILFKVEDSNSNSRNRSKNDPTNEINNKLNNNNNNNNDMNNNNSNGDQLISAFDTDFGYLNMDNNGYAKKEEFSRFTDDELRYDKENTMSYFDKHIKLDIFEEVEKSSNLIQAQMLFHAFSVLSIFSVYVMRKNDNNSSPFANTDLIFELNHRYSMVLRLLERLETFLKLRYQTSAGGGGGGVNNNNNNALSIKLEQEFTNLYLYNGNVLSSDHNTNTNTTNTITTTTTTDNGTKQNQHHSQDFGLEKTLYILKMGENVLNYIYDLNLKVCVFKKLGDSLSEIRKYLIDNESTLNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFT3</accession>
    <accession>A0A1D8PLK6</accession>
    <accession>Q5AF46</accession>
    <accession>Q5AF47</accession>
    <accession>Q5AF48</accession>
    <name>CFT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cleavage factor two protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CFT1</name>
        <name type="ordered locus">CAALFM_C402430WA</name>
        <name type="ORF">CaO19.10274</name>
        <name type="ORF">CaO19.10275</name>
        <name type="ORF">CaO19.10276</name>
        <name type="ORF">CaO19.2760</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720510.2">
        <property type="nucleotide sequence ID" value="XM_715417.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFT3"/>
    <dbReference type="SMR" id="Q5AFT3"/>
    <dbReference type="FunCoup" id="Q5AFT3">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFT3"/>
    <dbReference type="EnsemblFungi" id="C4_02430W_A-T">
        <property type="protein sequence ID" value="C4_02430W_A-T-p1"/>
        <property type="gene ID" value="C4_02430W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637848"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402430WA"/>
    <dbReference type="CGD" id="CAL0000179267">
        <property type="gene designation" value="orf19.10276"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02430W_A"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AFT3"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="PRO" id="PR:Q5AFT3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002440">
        <property type="entry name" value="Subunit of the mRNA cleavage and polyadenylation factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000290625" description="Protein CFT1">
        <location>
            <begin position="1"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1420" mass="161940" checksum="315406750D5D52C7" modified="2017-05-10" version="2">MDAYREFIDPSKVNNCVGCNFISSTKKNLIVGKGSLLQIFETIQLKQSTINKPQYRLKLIDQFKLQGTITDLKSIRTIENPNLDYLMVSTKYAKFSIIKWDHHLNTIATVSLHYYEHCIQNSTFEKLAVSELILEPTYNSVSCLRFKNLLCFLPFEVIEDDEDEEEEEEEDEEDEDEGEENIDDTKEKKDKKQSKTDTIEEDKNSTTTNQEPRLFYDSSFIIDATTLDSSIDTVVDMQFLHNYREPTIAVLSSKQEVWAGNLIKSKDNIQFQVLTLDLNLKSTISVFKIDNLPYEIDRIIPLPSPLNGTLLVGCNELIHVDNGGVLKRIAVNKFTRLITASFKSFQDQSDLNLKLENCSVVPIPDDHRVLLILQTGEFYFINFELDGKSIKRIHIDNVDKKTYDKIQLNHPGEVAILDKNMLFIANSNGNSPLIQVRYRDSSKTSDTKESKLNKIEEKEDNKDDDDNDDDDEDDLYKEEEEEETQKTISKSHIEFLYHDELINNGPSSTFTLGICSKEKFKCNLPNPNYNEVSILSNAGTDSQTKLNIITPTIQPSISSSLTFSQVNRMWNLNQKYLITSDDVNYKSEIFQIEKSYARMKSKHFINNELTINMHELNNGKFILQVTPKQIVLYDNKFKKRFTLNDEIKDDEILSSILRDEFLMIFLASGDVMIFVINTYNESYDKIEIPKLLDDTIITTGYITNSYLLSAVSKNVNLLLDNNTSSNKRKRKHSALSNSEGSKKNTGKSQPSTAAPPPPPKVNKVKTFVLVTGDNRIVAFNRFHGEKCYQLNHVDKFTENLSLGFFDPNQSTVDPFIKQIMLNELGDKFDTKDEYLTILTIGGEIYMYKLYFDGENYFFKKEKDLTITGAPDNAFPYGTSIERRLVYFPNLNGFTSIFVTGVIPYLILKTVHSIPRIFQFSKIAAMSISAFSDSKIKNGLIFLDNQQNARICELPLDFNYEFNLPMKHVDIGESIKSIAYHETSDTVVLSTFKQIPYDCLDEEGKPIAGIIKDIKDTPAMSFKGSIKLVSPYNWTVIETIELEDNEVGMTLKSMILDVGSESGSTLGSDPNSLIKKYNKKKREYIVIGIGKYRMEDLAANGIFKIYEIIDIIPEPGKPETNHKFKEIFKEETRGAITSICELSGRFLVSQGQKVIVRDLQDDGTVPVAFLDTPVYVSESKSFGNLLILGDPLKGCWLVGFDAEPFRMIMLGKDTQHISVECADFIINDDEIFVLVADNNNVLHLLNYDPDDPQSINGTKLLTKASFELNSTISCLRSLPLIDIEESVQTDALTNIAVPPPLPPNTTSNYFQVIGSTQDGSFFNVFPINEAAYRRMYILQQQLIDKEFHYCGLNPRLNRIGSIKLQNNETNTKPILDYDLIRRFTKLSDDRKRNLANKVSGKGIYQDIWKDIIRFEHTLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGW0</accession>
    <accession>Q3MPI9</accession>
    <name>Q5AGW0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C701510WA</name>
        <name evidence="10" type="ordered locus">orf19.13931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721414.1">
        <property type="nucleotide sequence ID" value="XM_716321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGW0"/>
    <dbReference type="SMR" id="Q5AGW0"/>
    <dbReference type="STRING" id="237561.Q5AGW0"/>
    <dbReference type="GeneID" id="3637049"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701510WA"/>
    <dbReference type="CGD" id="CAL0000184433">
        <property type="gene designation" value="orf19.13931"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01510W_A"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="InParanoid" id="Q5AGW0"/>
    <dbReference type="OMA" id="TWRNYTL"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="86"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000184433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="547" mass="60697" checksum="2C48FCE95CA56FF0" modified="2005-04-26" version="1">MSLFEKNTTPDQNLGEDQNQNQNQNHSNHSINNDGNDDKKDFISHKENYLEDSTSSEFDMVGLEANDTILHNKMKLINDAIDEIGFTPYHLKLFFLNGMGYCTDCMLTYLESSVRTFINYQFGYKFPVSNECYAGGMILGALVWGFGADLIGRRLAFNLSLLLSAIFTIMTGMMGNMASYCLFVLLSSFAAGGNLVLDTCVFLEYLPHKDQWLLTFFAFFWGIGQTIAVALAYAFLPNNSCESADYCPSHINRGWRYVFYTNGSIVLAMAILRLTVVRLKETPKFLVANNRDAEAVEVLQEIAHKYNRKCSLTLEQLLECGEIESNDDYRKHFSFGGTLSLMFQHLKILFATKKSAWSTSLLFFSWACLGIAYPLYSAFLPEYLATRGANISADTTSGVYRDLVISNVSSVGGPIIAGLLLYLLPVLGRKGVLFIGGVTTMALLFGYTAVRTRAQNVGLTSAVYCALYIYYGVMYAYTPEVMPSAARATGNCLCLFFTRISTAMVPIIAWYSDTSSAVPIWICGALVGVIGIVALALPFEPSKQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AHY8</accession>
    <name>Q5AHY8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial 54S ribosomal protein YmL27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">MRPL27</name>
        <name evidence="8" type="ordered locus">CAALFM_C103650CA</name>
        <name evidence="7" type="ordered locus">orf19.10582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721562.1">
        <property type="nucleotide sequence ID" value="XM_716469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AHY8"/>
    <dbReference type="SMR" id="Q5AHY8"/>
    <dbReference type="FunCoup" id="Q5AHY8">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AHY8"/>
    <dbReference type="GeneID" id="3636884"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103650CA"/>
    <dbReference type="CGD" id="CAL0000184130">
        <property type="gene designation" value="MRPL27"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03650C_A"/>
    <dbReference type="eggNOG" id="KOG4756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1778531_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AHY8"/>
    <dbReference type="OMA" id="KHTKYGE"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000184130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="168" mass="19308" checksum="D32A5E7FA518DEBB" modified="2005-04-26" version="1">MKVSQVLSFQGSVSSALRRPWQTFRDGTLYYGQLKSGSKRHALTGKQGNKHYYKGTRSTGIGSWDSRGRYHINWEKVRTYVVPEGLNNTELKALVSPKSPKFIQQVVGYRDHFKSPELAFHNAKDFIEYGANYSDVDLEQEGYIHRIVHPDILEAERKENMDVEGIKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI44</accession>
    <accession>A0A1D8PCX7</accession>
    <name>COQ4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein COQ4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Coenzyme Q biosynthesis protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">COQ4</name>
        <name type="ordered locus">CAALFM_C103160CA</name>
        <name type="ORF">CaO19.10526</name>
        <name type="ORF">CaO19.3008</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721506.2">
        <property type="nucleotide sequence ID" value="XM_716413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI44"/>
    <dbReference type="SMR" id="Q5AI44"/>
    <dbReference type="FunCoup" id="Q5AI44">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AI44"/>
    <dbReference type="EnsemblFungi" id="C1_03160C_A-T">
        <property type="protein sequence ID" value="C1_03160C_A-T-p1"/>
        <property type="gene ID" value="C1_03160C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636804"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103160CA"/>
    <dbReference type="CGD" id="CAL0000193093">
        <property type="gene designation" value="COQ4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03160C_A"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061241_0_2_1"/>
    <dbReference type="InParanoid" id="Q5AI44"/>
    <dbReference type="OMA" id="YYERHFH"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="PRO" id="PR:Q5AI44"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000388103" description="Ubiquinone biosynthesis protein COQ4, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <sequence length="323" mass="37590" checksum="71428280EF0F2060" modified="2017-05-10" version="2">MLKSTVNNTRIKCGHIDQRRNYLFTTLAGTVLGSFLWSKNNVLASKMENGELHYHDPNLKFNKKLFNGKPPFERRTPDYPGHVPLYNFEKVLMFLGSSMGAFFHPEENKYIVALGESTAITPILQNLRHKMLSDPVGRTILREKPRMTSDSLNLTYLRSLPDNTIGKNYVNWLDKEHVSPDTRVAVRYIDNEELAYIYQRYRECHDFYHAITGLPIIIEGEIAVKVFEFANIGIPMSGLGALFAPLRLKSSQRQRLREIYYPWAIKNGLFSKPLINVYWEKILEKDVDEFRQEMGIQQPPDLRNMRKEYFAKKKLEKQLQGGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJ82</accession>
    <accession>A0A1D8PJ48</accession>
    <name>END3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">END3</name>
        <name type="ordered locus">CAALFM_C301400WA</name>
        <name type="ORF">CaO19.1711</name>
        <name type="ORF">CaO19.9278</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proteomics" volume="4" first="2425" last="2436">
            <title>Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Yin Z."/>
                <person name="Stead D."/>
                <person name="Selway L."/>
                <person name="Walker J."/>
                <person name="Riba-Garcia I."/>
                <person name="McLnerney T."/>
                <person name="Gaskell S."/>
                <person name="Oliver S.G."/>
                <person name="Cash P."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15274137"/>
            <dbReference type="DOI" id="10.1002/pmic.200300760"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <text evidence="1">Cytoplasmic and cortical actin patches.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">Regulated by GCN4 and induced in response to amino acid starvation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721782.1">
        <property type="nucleotide sequence ID" value="XM_716689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJ82"/>
    <dbReference type="FunCoup" id="Q5AJ82">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJ82"/>
    <dbReference type="EnsemblFungi" id="C3_01400W_A-T">
        <property type="protein sequence ID" value="C3_01400W_A-T-p1"/>
        <property type="gene ID" value="C3_01400W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636644"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301400WA"/>
    <dbReference type="CGD" id="CAL0000174035">
        <property type="gene designation" value="END3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01400W_A"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AJ82"/>
    <dbReference type="OMA" id="DWLIPES"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="PHI-base" id="PHI:123071"/>
    <dbReference type="PRO" id="PR:Q5AJ82"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990964">
        <property type="term" value="C:actin cytoskeleton-regulatory complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0254">Endocytosis</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000349443" description="Actin cytoskeleton-regulatory complex protein END3">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EH 1" evidence="3">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EH 2" evidence="3">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="285"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15274137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="395" mass="44983" checksum="97584C909D9518D0" modified="2005-04-26" version="1">MPRLEESEIKKYWQIFQSLKPQNNKLTGDQLSSILKNSQLPQQQLSAIWELSDIDNDGKLDFEEFCIIMRLIFDVINGKLPNVPQELPSWLIPASKSAIIQANKAVNQGNNNFGDIDDDEDDKLSNDFDWYISPTDKSIYEKIYDSKCDSFGRIKYSSLNELYNGLTNVPSSEISSAWNLINPKSFETIDKDQTLVFLHILNQRENGKRIPRGVPASLRATFSKEVPNYDLSAQAKPSISATTETGKKSFAENYLNKIGGGVGASSTINNGRNEKGTDFSATQGTDWEEVRLRRELQDLERLLDKVQNDTKNQKDNSNNNQDNNDMLIKYEFEQLLKYKQNQLNSTTNASKNSTDLSSVKQDIEEIQNQVNTLQEFLTTKNQELLKLNQQIESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJC4</accession>
    <name>Q5AJC4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C301790CA</name>
        <name evidence="6" type="ordered locus">orf19.9236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721744.1">
        <property type="nucleotide sequence ID" value="XM_716651.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJC4"/>
    <dbReference type="STRING" id="237561.Q5AJC4"/>
    <dbReference type="GeneID" id="3636587"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301790CA"/>
    <dbReference type="CGD" id="CAL0000180239">
        <property type="gene designation" value="orf19.9236"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01790C_A"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003233_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AJC4"/>
    <dbReference type="OMA" id="LLHEMNY"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="972"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000180239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1250" mass="144309" checksum="912D21BD6BAD4E78" modified="2005-04-26" version="1">MSLNKNIKQKVVAITNDLEKLIPIGTLNFFNLPLDITDLQGVKPSYITPKLDNDLQQWSWLDIDYIIYLLSINHKSINPILFTLKYLLEKSYIQAIYKVVKVTRSYNRSDGTKSIDYLFSMCRIRLYSIPADVEGARHIREYRQLQSKSLKLDRQYASHFEQLLKYLDFSHSNWFIGKQLSIESLLHQGSLLLIDCQCTNELGTASNDELKFHLQRWSNKQSATKFTNDKSHTNNLSNTDTSGDRIKKIYDQIPSPDLSKYMVNEKNYQFIKQSKASISSTTDKLSTLANDSEHQDMIKIDGIKSTLYPFQVKSVGLMLERECIKRRTIMPNFIKLESPLSSNFYFDLFTKRIYLHADVMSLPLGGILGENMGLGKTLMCLSLINLTKYEITKIPSDNFLLYNEIEIHDEIKTLTEICREKIIHSSIPWKLYNLPTSVTANLAKHPGYFCIDLNDHEKNKRSHKSGFLINRNGVDTCKRASRTTGTKSTSYLKLYMSSTTLIIVPDNLFIQWVDEIAHHVEPNFLKILCAANYIKSDQIKDQFLPNPKFVNTIPESPVELIEYDVILISQSCLNKSFANKNRNSQKNGNSQVPSLRQVYWKRLIIDEGHIVQSKTSNAAQICRLLFSERRWAVSGTPTSGLTKIYMEEGEEDTGEKRNSHQAQNNIHVLENQFFAKTELQRLGVLISNFLKLEPYYTQPKLWTQDIINPLINSRYGSELIFSNIINSIIIRHQPNQTNIKLPNFHHEKVILEPCFQDSLSFNLLAAVLAVNAVTSERTGIDYMFHQSNRQQLRRLLSNIQRATFYWTGFQQQDVETLVSICDEALSKSGKYNESDVELLRRSKNIALIALNNQRWTIAQSIHELGYYISKDETNQYVSSVWGISAYTPDVSVFAAPQLLRLQMFWKENWVSSFDNEQTFRDKFENTAKTFWDQYLHQEFKKNDRHVAMDKLIKKNSGAELYTLDNISKSFNDVTPPKRTIDKEAQAQSPPPKKKRKVTFTDAVIEEDERKQKEPPQSKDAYDNVSKDNKTIEKSDRSIPPFDMTGLFKNMNILGTSSAKLTYLATSLLENQRNRIKSIVFFEFEDSAYYLIELLEILKIRHIIYANFITPIKRAQNLYDFSNYDVDKEENNGGICLVMNIAHSSHGLNIIAATHIYFINPVKQESIEAQAIKRAHRIGQTKEVTVKTLYLKGVDELKILSRNEKLKNAKNDKESFDAKEKEDNDNLLEFLDFDNSEHEYAAFPHPISIFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKZ2</accession>
    <name>GUP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Membrane-bound O-acyltransferase GUP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Glycerol uptake protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GUP1</name>
        <name type="ordered locus">CAALFM_C113540WA</name>
        <name type="ORF">orf19.4985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="5" first="51" last="62">
            <title>Yeast orthologues associated with glycerol transport and metabolism.</title>
            <authorList>
                <person name="Neves L."/>
                <person name="Oliveira R."/>
                <person name="Lucas C."/>
            </authorList>
            <dbReference type="PubMed" id="15381122"/>
            <dbReference type="DOI" id="10.1016/j.femsyr.2004.06.012"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="BMC Microbiol." volume="10" first="238" last="238">
            <title>Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p.</title>
            <authorList>
                <person name="Ferreira C."/>
                <person name="Silva S."/>
                <person name="Faria-Oliveira F."/>
                <person name="Pinho E."/>
                <person name="Henriques M."/>
                <person name="Lucas C."/>
            </authorList>
            <dbReference type="PubMed" id="20843317"/>
            <dbReference type="DOI" id="10.1186/1471-2180-10-238"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3 5">Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Acts only on GPI-anchored proteins, but not on free GPI lipids. Also involved in lipid metabolism, having profound effects on sphingolipid-sterol-ordered domains integrity and assembly. Involved in cell integrity and apoptosis (By similarity). Plays a role in virulence and antifungal resistance (PubMed:20843317).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Changes ergosterol plasma membrane constitution and distribution and presents an increased resistance to azoles. Impairs the development of hyphae, adhesion, to invasion, and formation of biofilms, all of which are significant virulence factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722191.1">
        <property type="nucleotide sequence ID" value="XM_717098.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKZ2"/>
    <dbReference type="SMR" id="Q5AKZ2"/>
    <dbReference type="FunCoup" id="Q5AKZ2">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AKZ2"/>
    <dbReference type="EnsemblFungi" id="C1_13540W_A-T">
        <property type="protein sequence ID" value="C1_13540W_A-T-p1"/>
        <property type="gene ID" value="C1_13540W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636171"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113540WA"/>
    <dbReference type="CGD" id="CAL0000180356">
        <property type="gene designation" value="GUP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13540W_A"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AKZ2"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000451585" description="Membrane-bound O-acyltransferase GUP1">
        <location>
            <begin position="1"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="204"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="365"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="395"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="20843317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="15381122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="584" mass="68733" checksum="D636040B1B4C245F" modified="2005-04-26" version="1">MNYLSQLGKLFSLETLDTRLNPTTNPIKRQSIIKKANPTSRWSTLEFKIYLTILIIVVPLMIKAAMESSNETNPNYPRFQHLLSDGWILGRKVDNSDQQYRFFRNNFPLLCGLIFIHVTLRKLINTFIIIPNGRYNNNFKRTYFDLIFGIIFLIGAHGINVFKISFHLFINYLIGKYIKNYKLAIWCTWIYGIFSLFFNEWFGDSSFGLSIFVNGSGYYTGIIPRWDVFYNFTLLRMLSFNLDYIERERKLGNNDGQLNLNKQENINGADNPPTLLNLDDRQRLSAPLPLDDYNVSNYIAYISYTPLFIAGPIITFNDYVYQSNYQQSSTTQNYQRIFMYAIRFLFCLLVMEFLLHFMYVVAVSKTKAWDGDTPFQISMLGMFNLNLIWLKLLIPWRLFRLWALLDGIDPPENMIRCMDNNFSALAFWRAWHRSYNRWVIRYIYIPMGGSGTGKYRIINSLLVFSFVAIWHDIELKLLMWGWLVVIFLIPEISATLIFSKYNKNWWYRYLCGIGAVINIWMMMIANLVGFCLGTDGMWKLLHDLFQTFEGGRFFIISSICLFVGAQIMFELRESELRRAIDVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALU1</accession>
    <name>Q5ALU1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C201740CA</name>
        <name evidence="2" type="ordered locus">orf19.9060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722534.1">
        <property type="nucleotide sequence ID" value="XM_717441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALU1"/>
    <dbReference type="SMR" id="Q5ALU1"/>
    <dbReference type="FunCoup" id="Q5ALU1">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALU1"/>
    <dbReference type="GeneID" id="3635733"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201740CA"/>
    <dbReference type="CGD" id="CAL0000174313">
        <property type="gene designation" value="orf19.9060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01740C_A"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ALU1"/>
    <dbReference type="OMA" id="KYTVFDR"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000174313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="113" mass="13714" checksum="ED985FC18221A309" modified="2005-04-26" version="1">MFESLVRSGGYVWKFTSRLTTTQKYKLRSRMKQVDENIKNIYQGLIAMENKSMGEPTGLKKIDYLQFEFPKENEMTTRDKYTTFNRHSKNYRKPVHRVPKWTKLSFRENPKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALV0</accession>
    <name>Q5ALV0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C201650WA</name>
        <name evidence="7" type="ordered locus">orf19.9051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722525.1">
        <property type="nucleotide sequence ID" value="XM_717432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALV0"/>
    <dbReference type="SMR" id="Q5ALV0"/>
    <dbReference type="FunCoup" id="Q5ALV0">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALV0"/>
    <dbReference type="GeneID" id="3635741"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201650WA"/>
    <dbReference type="CGD" id="CAL0000194048">
        <property type="gene designation" value="orf19.9051"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01650W_A"/>
    <dbReference type="eggNOG" id="KOG2098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018702_4_1_1"/>
    <dbReference type="InParanoid" id="Q5ALV0"/>
    <dbReference type="OMA" id="PIINNHT"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902974">
        <property type="term" value="P:meiotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000221">
        <property type="term" value="P:negative regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000194048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="543" mass="62703" checksum="7B5BECA5B6F678FF" modified="2005-04-26" version="1">MIYELRDFIPFIEFILNQDNKILDTPIYGELWIIGPLIQKSSNLRFTSTKDFLDYIIQFNIISGYSLEFSKDLNNNIDIKHLPKLISINFKGVLMLQSRLKGKQTFSQISNSKNHKLPTNLLQILEMSSKRDILPYTSTNSSLSSDLSFDVEFLQELINKPTARTILNKQKASLKTPEKPFHSICSDHNHINLLATVGLNKKEYSHFGSKQTIPVDVIHQRILKCRNILSNDVYKCVQERIHFLPIINNHTDLNLGDCSYLDTCHKLKSCRYLHYYTLTPMKKELSHSSKEEQQQRQIKLKGLEYTIGDCFSESFREPLPPQWINCDVRCLPFSILGKFAAIISDPAWDIHMSLPYGTCKDDELLSLPMHELQDEGIIMLWVTGRSIEIGRRALLKWGYQIYDEMIWIKLNQLRRTIVTGRTGHWLNHSKEHLLVGLKGNPIWINKRIDTDVVVSPTRETSRKPDEFYDIVERLVGTHSRKLEIFGRDHNTRPGWLTIGNQLQGVSLFEPELKYKYELYKQTTTGTTATTSISMSTSGSGGKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AM44</accession>
    <accession>A0A1D8PGK2</accession>
    <accession>Q5ALP5</accession>
    <name>RNA14_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RNA14</name>
        <name type="ordered locus">CAALFM_C202150CA</name>
        <name type="ORF">CaO19.1531</name>
        <name type="ORF">CaO19.9106</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722575.2">
        <property type="nucleotide sequence ID" value="XM_717482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AM44"/>
    <dbReference type="SMR" id="Q5AM44"/>
    <dbReference type="FunCoup" id="Q5AM44">
        <property type="interactions" value="1238"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AM44"/>
    <dbReference type="EnsemblFungi" id="C2_02150C_A-T">
        <property type="protein sequence ID" value="C2_02150C_A-T-p1"/>
        <property type="gene ID" value="C2_02150C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635749"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202150CA"/>
    <dbReference type="CGD" id="CAL0000183478">
        <property type="gene designation" value="orf19.9106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02150C_A"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AM44"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="PRO" id="PR:Q5AM44"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000023">
        <property type="entry name" value="mRNA 3'-end-processing protein RNA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000035">
        <property type="entry name" value="mRNA 3'-end-processing protein RNA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000238520" description="mRNA 3'-end-processing protein RNA14">
        <location>
            <begin position="1"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 2">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 3">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 4">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 5">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 6">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="791" mass="91659" checksum="6539A8F66A583BCF" modified="2017-05-10" version="2">MFIPQNKSKRLSLDKIGQLEEDLELNPLDYNKWQKLIDQLIIKDNQEQVRNTFDKYLKIFKFDGASWCKYIKYELNRDEKEKVENLFQQCLGITDNVELCRLYVDYVRGVTDFVTGGEKARGVVVQAFEFAINKVGIDITSESLWQDYIQFLQSWNPNANWEQQQKIDLIRKVYKKFLTIPTENIEVSWSQYTKWENELNPATASKFISEKSGEFMLARSWNTEFNRITDKSLKRNLNPGDHNDEDVVKQLKYWLRWLELEKENKLELKDETVNDKRIQYVYKQATYALPFVPEIWFQYVKYLLVQNEEGNLQESIRLLKEGGLVLNPKSMLLTFQLAELYERDNSFNNAKIVFKNLLDALQKDYNSVANQIAELKERIDPATDKDNIQEDDDDNEEEEEEENDNDNDNDNGGDSKQQPPSKKLKLNPNGGQNGSNSENNGEAVSAPSSSVKLPQVYRISLADSKQLLSFENEQKRLSDAITLTYVKFMIASKRSEGIKEARNVFKQARKFTDIGYQIFIESALLEHYSDKKSTALKIFDLGKKNFATNGKFLLNYLDYLIMINDVDTMRTVIQSSDANFTKEIGNLQEELKLTNLDPITRKKLEKQITNLKKFLKQLYKKYISFAATFLSLDVTHSFAKKCEQLFPKDDPIDLFTDRYKLDNINIIKKDELGRDDILTSFDGIIDEEELQRLKRRKLSNGSGSSSSYSFNEEESKSAIKNIEEQKTRVQQEQDQENQGINKPEESFVGPSIIALMSALPNASYFGLPSESVFNSEKLVTLFANLSNIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMG6</accession>
    <name>Q5AMG6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C401090CA</name>
        <name evidence="2" type="ordered locus">orf19.12149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722749.1">
        <property type="nucleotide sequence ID" value="XM_717656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMG6"/>
    <dbReference type="SMR" id="Q5AMG6"/>
    <dbReference type="STRING" id="237561.Q5AMG6"/>
    <dbReference type="GeneID" id="3635685"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401090CA"/>
    <dbReference type="CGD" id="CAL0000187774">
        <property type="gene designation" value="orf19.12149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01090C_A"/>
    <dbReference type="eggNOG" id="ENOG502S2DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021934_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AMG6"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="46"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000187774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="381" mass="43094" checksum="E0CBF2EE52CA9E4B" modified="2005-04-26" version="1">MTRYRLTYQLKNIALEFGENDGKYFIQLGHSSTGKILNLSTLPSYLTERKVIIIDSVKSGTGRTPGKDIYSDILDPLFKELSIEHEYHATKSATSISELASSLKDHKVTIIFISGDTSINEFINSLNDSEKGEIAIFPIPGGTGNSLSLSLNITNPLDAIIRLFSAGTTSPLNLYEVDFPQGSHYLIANELGSPVPSHLKFLVVLSWGFHASLVADSDTPELRKHGIKRFQLAAHQNLSRDQKYEGDFYINDVELNGPFAYWLVTASQRFEPTFEISPKGDILKDELYVVTFNTQNTQYYIMDIMKEVYDKGSHIKNPNVVYKKLDKNDKIQLKTKNSKPLIQRRFCVDGSIIALPETESHEIYIHVKDNSQHSWKLYIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMH0</accession>
    <name>Q5AMH0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial distribution and morphology protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C401140CA</name>
        <name evidence="4" type="ordered locus">orf19.12146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722745.1">
        <property type="nucleotide sequence ID" value="XM_717652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMH0"/>
    <dbReference type="SMR" id="Q5AMH0"/>
    <dbReference type="STRING" id="237561.Q5AMH0"/>
    <dbReference type="GeneID" id="3635657"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401140CA"/>
    <dbReference type="CGD" id="CAL0000199336">
        <property type="gene designation" value="orf19.12146"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01140C_A"/>
    <dbReference type="eggNOG" id="KOG3481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1495984_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AMH0"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971232" description="Mitochondrial distribution and morphology protein 35" evidence="3">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000199336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21067" checksum="26BFC34B9D3CF83E" modified="2005-04-26" version="1">MMMLLLFSDLLWFFFFACRCVCVNFLQKRVSFLICSPPFKNCAKYGKRFHLHLPPLTIYHQKLSVVVEKKKETKIKAIPPASLKHTVIYIDMGNIMSVSFAPECTPAKNAYDDCFNKWYTEKFLKGKSMENECTEFWDTYITCINANLAKQGIKPMLDKAREDQPFDHQEIKESLNNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANG2</accession>
    <name>Q5ANG2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C304780CA</name>
        <name evidence="8" type="ordered locus">orf19.13362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANG2"/>
    <dbReference type="SMR" id="Q5ANG2"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANG2"/>
    <dbReference type="GeneID" id="3635214"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304780CA"/>
    <dbReference type="CGD" id="CAL0000178050">
        <property type="gene designation" value="orf19.13362"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04780C_A"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ANG2"/>
    <dbReference type="OMA" id="MTNHYLR"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Erv"/>
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    </dbReference>
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        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="153"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000178050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="345" mass="39464" checksum="8E3CBE6C7A925653" modified="2005-04-26" version="1">MDSFAQKVKTFDAFPKVDPQHQVRSQRGGLSTLLTYFCGLLILWIEIGGYIGGYVDRQFTVDDQIRSALTINVDMIVAMPCQFIHTNVEDITHDTYLAGETLNFEGIHFFVPDSFKINNPNDFHETPDLDEVMQESLRAEFRSEGARVNEGAPACHIFGSIPVNQVRGDFRITGKGFGYRDRSHVPFESLNFSHVIQEFSFGEFYPYLNNPLDATGKVTEERLQTYMYYAKVVPTLYEQLGLEIDTNQYSLTENQHVIKVDQSTHRPDGIPGIYFLYDFEPIKLVIREKRIPFFQFIAKLATIGGGLLIAAGYLFRLYEKLLFIFYGQKAVQQNREQKTGGLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APF5</accession>
    <name>Q5APF5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C109470CA</name>
        <name evidence="10" type="ordered locus">orf19.12274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723497.1">
        <property type="nucleotide sequence ID" value="XM_718404.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APF5"/>
    <dbReference type="FunCoup" id="Q5APF5">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5APF5"/>
    <dbReference type="GeneID" id="3634761"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109470CA"/>
    <dbReference type="CGD" id="CAL0000177270">
        <property type="gene designation" value="orf19.12274"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09470C_A"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="InParanoid" id="Q5APF5"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071454">
        <property type="term" value="P:cellular response to anoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000177270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="328" mass="35866" checksum="BB0C1ED0D1EC7144" modified="2005-04-26" version="1">MASSIPGPVSLPQSKYDLTTYWGRVKHCAEISDPTMLLNTTHDIETAKRMVWDYKNGVTSKMSPELWRAKKVLDSTLHPDTGETVFLPFRMSSCVLSNLVVTAGMLTPNLGTAGTLFWQIANQSLNVAINTANANKSHPLTTKQIVTNYTLAVSASCSVALGLNSLVPRLKSLKPNTRMILGRLVPFAAVVSAGIVNVFLMRSEELKKGITVFDRKGNEVGTSKQAAWYAVGETAASRVINATPIMVIPPLILVKLQQSRFLKSKSKGVETLVNIGLIFATSLVALPFALAVFPQRRVLAVNKLESKFHELKDKDGNDIKELEFNRGI</sequence>
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <begin position="209"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000179624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="376" mass="42478" checksum="20E82CF8407E26E7" modified="2017-01-18" version="1">MTIFTTLGMFIVDENRYVDSNNNLLPPPPSSSSLQQTNIIGGAGTYAIMGARIICDDRQDLIDQISGIIDMGSDFPFEIKQELDTWKTRGVIYRENPHRLTTRGVNIYRYTDNNNNKSSNESIDNELEAEPEQDAIRYFEYVTPKLRIEINDILEYPNLKQSSNYHLICSIERCKSLIDSITQFNPSAKFIYEPLPDDCVFENLEFLQNDILPKIHVFTPNLNEARLLLGLKDNENETNKSDDNDELQKISQQFTNHLQLSNSGTVLRCGAQGCYINTKSGDKFQLPAYHQDQTKVVDVTGGGNSFCGGFMMAYHLSDGDWLASGVAGIISSGCIIEKLGMPTVSDDSKFNNKSLRDRLDTYLTENPTLKVDFNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCP0</accession>
    <name>A0A1D8PCP0_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ordered locus">CAALFM_C101890CA</name>
        <name evidence="3" type="ordered locus">orf19.12009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707866.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PCP0"/>
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        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCP0"/>
    <dbReference type="GeneID" id="3645427"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101890CA"/>
    <dbReference type="CGD" id="CAL0000191039">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01890C_A"/>
    <dbReference type="eggNOG" id="KOG2689">
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    <dbReference type="Proteomes" id="UP000000559">
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0036503">
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    <dbReference type="PANTHER" id="PTHR46424">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
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    </dbReference>
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        <property type="entry name" value="UBX7_N"/>
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    </dbReference>
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        </location>
    </feature>
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    </feature>
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            <begin position="129"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="509" mass="57269" checksum="F93C0C50C5C8BDA0" modified="2017-01-18" version="1">MSDNIHRSFTTSVEQAVSSTISEQKALFVYLVTSTYTENTDTFLPKFIDDQTTAIIKSNFILLKLTQNTVEFGYFSQLFKDLIVPSFYIVNEGKIEAVISNDTTKEEFIKIIGKLTKKVKSSDNVSTRENISNENNVVIENSARNNSQSSSDHDKSVRKYQEKVARMRQERIEEKKRLRALLEADQKERKLKEQENANVESKLSVHSPSSRKTSTSSTNSCVLSIKLFDGSTMKCEFKSQDTLIDVRKWLDSEVEIIPPAKSMPSFATTAYPYPTGYAFHRPALPRVTYSEEQESNTLANLDLTPRSALILKPTYNEVDSDKPDNDVGKTGIFRSLLNVLFSLGTTIFSVFSYGINAPHNQEHRDSSPRYDHRDADNLQSSEDDQSINIHRPPIAGHPGSLMFESTSASSLLLNIEPNVDETSGDVMRPHSPPIPIESHFNQHSQQAYSTASNINSRPTTPGSRSLRKMPTVHGDSMETSSNKEKTHKVDTYNGNSINVNERDDENSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705090.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PD32"/>
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        <property type="gene designation" value="orf19.8639"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_03720C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="415532at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="116"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000200131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="590" mass="68870" checksum="2E1E047183809220" modified="2017-01-18" version="1">MPVPTSTLIKTEEEERAIRLAEQQQVWERQRLEFEERRRRAESQRIGSPFKHPWWTAFTDAGPEPRCLDEWLTVEISNSIREKPDWKTKYKNEEIVTKWKREIKEQCQDKTKYLDQIIDYVFKELQWYEDVEKDLNTFQIGCDYRIAYSDGAVNETLKKSFSIGAQKLVESFGSNIDYHPGSHNQVIDLVHPSLYIVQYDKTPVLKNGQLEIVKYGEQIEHAKPGVDQYGVSKRFQWIPALMTKNSNGKFEFGSYINNLHPIKYKDLYDSISDIFNAAVPGLNCVLTRYASQEFVRIPVPRGSDAYTDEYHKEREELDAILDREAEETGNDYDWERMEEFEKDKSKYLCELIPAWEQAPVFDKPIDLSTFENLKVIVKLINIELTPENPSYAGGSWHVEGGINEDIIATVLYYYDVENITESRLSFRTGFDDPNYEQGDDFYTETIFGIKDEKVMVREIGGIEAKEDRVVVFPNMFQHHVDPFELKDKTKPGHRKILCFFIVDPYNHNVISTDNVPPQQKEWWDDSSLDYLFPGNLKQQILDLKGDESSWPMTLEQAKEARVALMDERSAKGEGDEFEGAFTRSFSLCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDW1</accession>
    <name>A0A1D8PDW1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exosome non-catalytic core subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C106540CA</name>
        <name evidence="10" type="ordered locus">orf19.13638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718846.2">
        <property type="nucleotide sequence ID" value="XM_713753.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PDW1"/>
    <dbReference type="GeneID" id="3639520"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106540CA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C1_06540C_A"/>
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    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0271">Exosome</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000184319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="374" mass="41773" checksum="7740CFBFFC071087" modified="2017-01-18" version="1">MRFGDEHQTLKYKQSPNSKNQTSSMAELKQVTFSPEVLARIAPDVSLQRHLALGVRPNLRNFTEFKPVEVSNSTQFQDNNDNVFSSSVVKSGSTTIINTITLGVVENFNSNESEYATVYPCVEILRGRLGAPTDEEMILSQDLFETLYHNKIIPSTSLKINNLGISIKDDQTTTTSQTNSTIYYPDLNPGQWEYINLTSHHHKSYSFVLLSNIKVYSKSTSTSSLFDLCYLSMLEALKSLKLPRCYVSESFTTKVAMKSRRSNTRGLVDTNKASINIDLNKSLYEKIDLNIKSGTIASNFGVISHEGNTILLADLEGEAEESSVLSRLSIITNNDSINKISLVNGDPESEITLEMLKNAIEISKQRSREQGQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE92</accession>
    <name>A0A1D8PE92_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10 11" type="primary">NTG1</name>
        <name evidence="11" type="ordered locus">CAALFM_C108200WA</name>
        <name evidence="10" type="ordered locus">orf19.12564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717635.2">
        <property type="nucleotide sequence ID" value="XM_712542.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE92"/>
    <dbReference type="SMR" id="A0A1D8PE92"/>
    <dbReference type="FunCoup" id="A0A1D8PE92">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PE92"/>
    <dbReference type="GeneID" id="3640746"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108200WA"/>
    <dbReference type="CGD" id="CAL0000179989">
        <property type="gene designation" value="NTG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08200W_A"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE92"/>
    <dbReference type="OMA" id="RGKRCDL"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000025">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="9">
        <location>
            <begin position="108"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000179989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="320" mass="36212" checksum="4D06A8C4B1A51F28" modified="2017-01-18" version="1">MKVTKRAISDTSGSSKRIKLEHIEVEIESETTELAPNVFTKVDPEDMAKCNGPPKWSEIYNQLVWMRSKFFAPVDTQGCERMPNTINRNIKTRNPKIYRFQLLISLMLSSQTKDEVNYEAMKNLHNGLLKVHPDGLCIESVLKLSESEIDAYIKKVGFHNRKAQYIRKTCSILMENHGGDIPKTIEEIVALPGVGPKMGFLLLQSGWGINAGIGVDVHLHRLALMWGWVSPKANTPEKARIELQEWLPKDYWTDINPLVVGFGQVICVPRAANCDICTLARDGLCKGVNKKLLKTPLSEERINKLSKQRADLSQLLKEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE95</accession>
    <name>A0A1D8PE95_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C107960WA</name>
        <name evidence="9" type="ordered locus">orf19.12533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717605.2">
        <property type="nucleotide sequence ID" value="XM_712512.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE95"/>
    <dbReference type="SMR" id="A0A1D8PE95"/>
    <dbReference type="FunCoup" id="A0A1D8PE95">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PE95"/>
    <dbReference type="GeneID" id="3640725"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107960WA"/>
    <dbReference type="CGD" id="CAL0000186441">
        <property type="gene designation" value="orf19.12533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07960W_A"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE95"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000186441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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                <person name="Federspiel N.A."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Weissman J.S."/>
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        </citation>
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                <person name="Schwartz K."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
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            <end position="78"/>
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    </feature>
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        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
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            <position position="136"/>
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    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW27057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="226" mass="25526" checksum="1E647FBA0D18C8CE" modified="2017-01-18" version="1" fragment="single">VEQSNVETEDAGNSXIQDEVSQEGRIVNEQTDIVDTVAKXIENEXISPINSLDDHTELATDSGNDSNSTESDIQSKNEISPVINEKNTEIIQKHIESILXDKRLDEFETYNVDEIENVINDDDIAEANPLPDENNDVQMNESSDNNHGMSRAKKKYTFEKEVNEKIAGTKHSLDTTDPREAIRVLNTGETKRIEPKKREXPITVKLNKRSQYKSPYVTRSGRTVII</sequence>
</entry>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PGA9"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="81"/>
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        </source>
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            <dbReference type="CGD" id="CAL0000200800"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="538" mass="59562" checksum="B002860100E1D64D" modified="2017-01-18" version="1">MTQSDLNQSDSVSPQLSSFATDPTDQEKKLTEFNDDNKSVTSKDEDTKMSRNFSTLQIVTIGFGLTNSWLGISSTLILSISSLGPLLVVYGILIVASVSVCIAVTLGEMASAMPSAGGQYVWARVLAPKKYSSFLAYITGSISWGGAIFTTASMNLAVAYQVLGFWNMTHPDHVNQKWEVFIIYNILNWILFFFNIWHRFLPMIGDSVFGISLTSYCIILITVLVCARGHYQDAKFVFVHAVNNTGWPSKGIAFIVGLVNPAWAFSCLDSVTHLSEETAHPERDVPRAVLSTVGIGFVTSFTFSIAMFFCIRNLEEIMNSATGFPMLDIFYQALGSTKVGAICLGSLITLVATGCTLSCIIYQSRLLFSFSRDNGMPLSKYLSIIDPKTGGPFYAHLFSTVIVSVVSVLVFSDAALQATALACVSFLLIAYSIPTICLLARRRQIRHGPFWLGKIGVFCNFVLLAWCIFAVVFFSFPANYPVTAEGMNYFCVVLVVYIICMLGYWWFPIKKYACKYNFRGGNLNQEEVEFPDVCLTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGE9</accession>
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        <name evidence="10" type="ordered locus">orf19.9033</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_717415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGE9"/>
    <dbReference type="SMR" id="A0A1D8PGE9"/>
    <dbReference type="FunCoup" id="A0A1D8PGE9">
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C201510CA"/>
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        <property type="gene designation" value="orf19.9033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01510C_A"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PGE9"/>
    <dbReference type="OMA" id="IMCASYL"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
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    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
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    </dbReference>
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        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
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        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000197395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="270" mass="30732" checksum="9383E2C6BDBC3994" modified="2017-01-18" version="1">MAISLFVGYKALLNNETPVSCIVVDSKSDKIISIGYNYTNHSLNGTQHAEFIALQRFGEQKSSIDYNDLILYVTVEPCIMCASYLRQLGIKKVIFGCGNDRFGGNGTILSIHSDITLPNAAYSSIGGICRTEGIQLLRNFYIQQNESAPNPKIKKNTDIESKEYPENQFCSISKDEFIEFYGNERVHIYDGKIFEITPLQNKGYDIKELISLDMMQKVPFLEDELGQITDEQIIEFHNLFFNINDDGTVNYKKPIGKYNSKKRHFANDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGL1</accession>
    <name>A0A1D8PGL1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C202410WA</name>
        <name evidence="8" type="ordered locus">orf19.9137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722606.2">
        <property type="nucleotide sequence ID" value="XM_717513.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGL1"/>
    <dbReference type="SMR" id="A0A1D8PGL1"/>
    <dbReference type="FunCoup" id="A0A1D8PGL1">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGL1"/>
    <dbReference type="GeneID" id="3635755"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202410WA"/>
    <dbReference type="CGD" id="CAL0000184176">
        <property type="gene designation" value="orf19.9137"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02410W_A"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGL1"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000184176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="189" mass="21429" checksum="97E7B2C204E9E86F" modified="2017-01-18" version="1">MALYYNLVFGLLVFEMIFFGVLSLPYPRKIRRSILSTVSAPFKNEQFQIAIKCILGFVLVLFIDSVNRVYAVTTELHSSTASPGSTAVVDRSEVQARRFYAQRNMYLCGFTLFLTLILTRTYSLVAELIATKDKVDDLKSTETVTEDSATVAKLKKELAQKDEDLEILKNQAKSLSSEYEDVSELKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGS6</accession>
    <name>A0A1D8PGS6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C202870WA</name>
        <name evidence="9" type="ordered locus">orf19.13239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330756.1">
        <property type="nucleotide sequence ID" value="XM_019475211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGS6"/>
    <dbReference type="SMR" id="A0A1D8PGS6"/>
    <dbReference type="FunCoup" id="A0A1D8PGS6">
        <property type="interactions" value="1099"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGS6"/>
    <dbReference type="GeneID" id="3642972"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202870WA"/>
    <dbReference type="CGD" id="CAL0000194939">
        <property type="gene designation" value="orf19.13239"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02870W_A"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGS6"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000194939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="191" mass="21807" checksum="88500489CEF791F6" modified="2017-01-18" version="1">MSKKTTGDDIWKNNVEKINSELFTLTYGSVVAQLCRDFQNNYIEVNNQLDKMGYNIGLRLIEEFLAKTGIRRCQTFKETAEVISKLGFRIFLNIQPTVENWSNDGKSCSLIIPEPNPLTEFVELPITADNKIAKELWYSQILCGVLRGALQMVQLDCDVSFVKDVLRGDDRTEIRLKLNRILKDEVPAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGX5</accession>
    <name>A0A1D8PGX5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sap98p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">SAP98</name>
        <name evidence="6" type="ordered locus">CAALFM_C203680WA</name>
        <name evidence="5" type="ordered locus">orf19.8472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720976.2">
        <property type="nucleotide sequence ID" value="XM_715883.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGX5"/>
    <dbReference type="SMR" id="A0A1D8PGX5"/>
    <dbReference type="STRING" id="237561.A0A1D8PGX5"/>
    <dbReference type="GeneID" id="3637435"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203680WA"/>
    <dbReference type="CGD" id="CAL0000201944">
        <property type="gene designation" value="SAP98"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03680W_A"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGX5"/>
    <dbReference type="OMA" id="NQSIVWA"/>
    <dbReference type="OrthoDB" id="5839471at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000231">
        <property type="entry name" value="Sap98p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000188">
        <property type="entry name" value="Sap99p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111108" evidence="3">
        <location>
            <begin position="18"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="58"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000201944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="364" mass="39712" checksum="6A66FA7E3EEF130E" modified="2017-01-18" version="1">MIFNILSFISLAIFVDAVALKSNPKVISFDFELRFSDPIKRDTNFGTGTAAPVKDTHWSFPLKIGSNQDPVTLAADTGSWLIQINDANATCPNCHKHGTYNSSGSSTVVKSGKTARSFFTRSAYYIGELVSDSIQIGNLQIPQVTFNDVYNSTAGDGIFGLARPPSDKNQSIVWAAKYHGLVDKAAYSIYLQNLDGTPGALTVGGYDAAKVDGDITWTSIRNANVQAHLGHIEINEEIIDVNKNYTIDTGGRYGFLPEAAYNQVIANLPEDPKFGADRGQITCSLLEGKNFTYNLNGVDYTFPLRTLYVPTENTDHCYLALLKGNAAQLGAYVFRNLFVAVDFEDDLIGLASLKNTTATNIRPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH98</accession>
    <name>ITR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myo-inositol transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ITR1</name>
        <name evidence="10" type="ordered locus">orf19.3526</name>
        <name evidence="11" type="ORF">CAALFM_C204940CA</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2008" name="Infect. Immun." volume="76" first="2793" last="2801">
            <title>Candida albicans uses multiple mechanisms to acquire the essential metabolite inositol during infection.</title>
            <authorList>
                <person name="Chen Y.L."/>
                <person name="Kauffman S."/>
                <person name="Reynolds T.B."/>
            </authorList>
            <dbReference type="PubMed" id="18268031"/>
            <dbReference type="DOI" id="10.1128/iai.01514-07"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Major transporter for myo-inositol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Decreases myo-inositol import into cell (PubMed:18268031). Virulence is not affected in a mouse model of disseminated infection (PubMed:18268031). Simultaneous disruption of INO1 results in lethality (PubMed:18268031).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714885.1">
        <property type="nucleotide sequence ID" value="XM_709792.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH98"/>
    <dbReference type="SMR" id="A0A1D8PH98"/>
    <dbReference type="FunCoup" id="A0A1D8PH98">
        <property type="interactions" value="1289"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH98"/>
    <dbReference type="EnsemblFungi" id="C2_04940C_A-T">
        <property type="protein sequence ID" value="C2_04940C_A-T-p1"/>
        <property type="gene ID" value="C2_04940C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643440"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204940CA"/>
    <dbReference type="CGD" id="CAL0000201160">
        <property type="gene designation" value="ITR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04940C_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH98"/>
    <dbReference type="OMA" id="ETGWRWM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
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        <property type="term" value="P:myo-inositol transport"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000456706" description="Myo-inositol transporter 1">
        <location>
            <begin position="1"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P30605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="18268031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="18268031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="18268031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000201160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW27513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="554" mass="59703" checksum="AA2B96199426B2AC" modified="2017-01-18" version="1">MGSSTNNTQSKATPSVLENEVNSSKSSVVSSTSSAKGLLRETTNHGTMETSSVQISESESRPSKMVLVLTLASSISGFMFGYDTGYISSALVQIGTDLSNKILTSGEKEFITSATSLGALLGAVVGGVLANLIGRRRVLLGSNIIFVVGTIIQLAARTVWTMIAGRFVLGWGVGIASLIAPLMISELAPAKYRGRLIVTNVIFITGGQLIAYFINWGLTRVSHGWRVSVGLCMVPPVLQFVLFWFLPDTPRFYVMNGNFEKARQVLRKVHVDPSDEFVNATIDEMIASDSTVPGNGPLQKAWKSIKIIHTTPGNFRALILACGLQGIQQFTGFNSLMYFSATIFETIGFHNATAVSIIIAATNFVFTGIAICIIDKVGRRRILLVGMPCMCISLIVCAVAFHYLNVDFSTGTVVSRGINGWGIVVIIGMILYVASYAIGIGNAAWVGVELFSDVNVRSIGAMYAACTNWAGSLVIASTFLTMLENITPTGTFSFFAGLCFIAFFFVYFLLPDTAGLELEETTDFLSNGFNVKQAAQLSKERKKHSKFAKSKPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIN1</accession>
    <name>A0A1D8PIN1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C210170CA</name>
        <name evidence="8" type="ordered locus">orf19.9333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714409.1">
        <property type="nucleotide sequence ID" value="XM_709316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIN1"/>
    <dbReference type="STRING" id="237561.A0A1D8PIN1"/>
    <dbReference type="GeneID" id="3643931"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210170CA"/>
    <dbReference type="CGD" id="CAL0000176334">
        <property type="gene designation" value="orf19.9333"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10170C_A"/>
    <dbReference type="eggNOG" id="ENOG502S77Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIN1"/>
    <dbReference type="OMA" id="HPYLIYA"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000176334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31112" checksum="3E6DED0148A172A9" modified="2017-01-18" version="1">MAGTCITTIKLLGVGSLGLLSSSIIYQSLTKLPELIHQFNCQFNTNKDGGTHSSITLFEQQLYRLKNIIFGNRLINGALTAISTGLFALAFKYSVSNEKHPYLIYAALGAPLSFISLYYNIYSVEEKILSQQKSKSTSVAKTRTKSKHSESSTTNQEDAQAYDDEDEPAELISKITSSDSLLGKSYVHLSDESGISTPNSTTSHPSTPKLEPHQQEQEQEQPTPADDDVELEVEQEVENILIKKQVVQNLKKIESGYTIASYVSGISFVIASIGLIGDYYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIR7</accession>
    <name>A0A1D8PIR7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mtr2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">MTR2</name>
        <name evidence="2" type="ordered locus">CAALFM_C210640CA</name>
        <name evidence="1" type="ordered locus">orf19.5342.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330819.1">
        <property type="nucleotide sequence ID" value="XM_019475274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIR7"/>
    <dbReference type="SMR" id="A0A1D8PIR7"/>
    <dbReference type="FunCoup" id="A0A1D8PIR7">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIR7"/>
    <dbReference type="GeneID" id="30515167"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210640CA"/>
    <dbReference type="CGD" id="CAL0000193047">
        <property type="gene designation" value="MTR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10640C_A"/>
    <dbReference type="eggNOG" id="ENOG502RZK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIR7"/>
    <dbReference type="OMA" id="FDCHLIP"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="Gene3D" id="3.10.450.50">
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        <property type="entry name" value="NTF2-like_dom_sf"/>
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        <property type="entry name" value="Mtr2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000193047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="181" mass="20468" checksum="E6748D4C99E87D87" modified="2017-01-18" version="1">MNQDPTQQLEPFLKRFLASLDLSYTQPTSQPFPNVESYATQLGSNLKRSSAIIVNGQPIIPSPQEDCKLQFQKKWLQTPLSSHQLTSYDGHLIPGTGTFVVHFSAKVRFDQSGRNRLGESADLFQENNSIVSKTNQRPIWGSWFGVDVNLVVDENVMQDGEIINSMDYRFTYVPNDSIIKV</sequence>
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<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ01</accession>
    <name>PMA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane ATPase 1</fullName>
            <ecNumber evidence="4 7">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PMA1</name>
        <name type="ordered locus">CAALFM_C300720WA</name>
        <name type="ordered locus">orf19.12838</name>
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    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="5566" last="5574">
            <title>The Candida albicans plasma membrane and H(+)-ATPase during yeast growth and germ tube formation.</title>
            <authorList>
                <person name="Monk B.C."/>
                <person name="Niimi M."/>
                <person name="Shepherd M.G."/>
            </authorList>
            <dbReference type="PubMed" id="8366041"/>
            <dbReference type="DOI" id="10.1128/jb.175.17.5566-5574.1993"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1996" name="Biochim. Biophys. Acta" volume="1284" first="181" last="190">
            <title>Functional complementation between transmembrane loops of Saccharomyces cerevisiae and Candida albicans plasma membrane H(+)-ATPases.</title>
            <authorList>
                <person name="Mason A.B."/>
                <person name="Kardos T.B."/>
                <person name="Perlin D.S."/>
                <person name="Monk B.C."/>
            </authorList>
            <dbReference type="PubMed" id="8914582"/>
            <dbReference type="DOI" id="10.1016/s0005-2736(96)00128-9"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Microb. Drug Resist." volume="15" first="77" last="83">
            <title>Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase.</title>
            <authorList>
                <person name="Billack B."/>
                <person name="Santoro M."/>
                <person name="Lau-Cam C."/>
            </authorList>
            <dbReference type="PubMed" id="19432523"/>
            <dbReference type="DOI" id="10.1089/mdr.2009.0872"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="FEMS Yeast Res." volume="13" first="302" last="311">
            <title>Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Keniya M.V."/>
                <person name="Cannon R.D."/>
                <person name="Nguy'n A."/>
                <person name="Tyndall J.D."/>
                <person name="Monk B.C."/>
            </authorList>
            <dbReference type="PubMed" id="23374681"/>
            <dbReference type="DOI" id="10.1111/1567-1364.12035"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2019" name="Front. Microbiol." volume="10" first="1012" last="1012">
            <title>Candida albicans Pma1p Contributes to Growth, pH Homeostasis, and Hyphal Formation.</title>
            <authorList>
                <person name="Rane H.S."/>
                <person name="Hayek S.R."/>
                <person name="Frye J.E."/>
                <person name="Abeyta E.L."/>
                <person name="Bernardo S.M."/>
                <person name="Parra K.J."/>
                <person name="Lee S.A."/>
            </authorList>
            <dbReference type="PubMed" id="31143168"/>
            <dbReference type="DOI" id="10.3389/fmicb.2019.01012"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2025" name="Gut Microbes" volume="17" first="2455508" last="2455508">
            <title>PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression.</title>
            <authorList>
                <person name="Xu Z."/>
                <person name="Qiao S."/>
                <person name="Wang Z."/>
                <person name="Peng C."/>
                <person name="Hou Y."/>
                <person name="Liu B."/>
                <person name="Cao G."/>
                <person name="Wang T."/>
            </authorList>
            <dbReference type="PubMed" id="39886799"/>
            <dbReference type="DOI" id="10.1080/19490976.2025.2455508"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5 6 7 8">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (PubMed:19432523, PubMed:23374681, PubMed:31143168, PubMed:8366041, PubMed:8914582). Plays a role in the establishment of cell polarity and hyphal growth (PubMed:31143168). Acts as a pathogenic factor that, when transported by extracellular vesicles (EVs), activates host dendritic cells, promotes cytokine secretion and migration of the cDC2 subset in the gut, thereby promoting TH17 differentiation and progression of colitis (PubMed:39886799).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="3 7">Glucose addition rapidly activates the ATPase activity twofol (PubMed:8366041). Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a synthetic selenium-containing compound acts as an inhibitor of PMA1 activity (PubMed:19432523).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">11.9 mM for Mg(2+)-ATP at pH 6.5</KM>
            <KM evidence="4">3.9 mM for Mg(2+)-ATP at pH 7.5</KM>
            <Vmax evidence="7">0.8 umol/min/mg enzyme towards Mg(2+)-ATP during yeast growth at pH 4.5 without glucose</Vmax>
            <Vmax evidence="7">1.5 umol/min/mg enzyme towards Mg(2+)-ATP during yeast growth at pH 4.5 with glucose</Vmax>
            <Vmax evidence="7">0.6 umol/min/mg enzyme towards Mg(2+)-ATP during germ tube formation at pH 6.7 without of glucose</Vmax>
            <Vmax evidence="7">1.3 umol/min/mg enzyme towards Mg(2+)-ATP during germ tube formation at pH 6.7 with glucose</Vmax>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Extracellular vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="7">Expression increases up to sixfold during yeast growth and twofold during germ tube formation.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6">Decreases plasma membrane ATPase-specific activity and cytosolic pH (PubMed:31143168). Impairs glucose response, alters cation responses and vacuolar morphology, and reduces filamentation competence (PubMed:31143168). Leads to the inability to aggravate colitis (PubMed:39886799).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717759.2">
        <property type="nucleotide sequence ID" value="XM_712666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJ01"/>
    <dbReference type="SMR" id="A0A1D8PJ01"/>
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    <dbReference type="STRING" id="237561.A0A1D8PJ01"/>
    <dbReference type="EnsemblFungi" id="C3_00720W_A-T">
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        <property type="gene ID" value="C3_00720W_A"/>
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    <dbReference type="GeneID" id="3640531"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300720WA"/>
    <dbReference type="CGD" id="CAL0000187161">
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    <dbReference type="VEuPathDB" id="FungiDB:C3_00720W_A"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PJ01"/>
    <dbReference type="OMA" id="VIEFHPF"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008553">
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:proton export across plasma membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000463064" description="Plasma membrane ATPase 1">
        <location>
            <begin position="1"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="19432523"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="23374681"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="31143168"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="39886799"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="8366041"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="8914582"/>
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    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="8366041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="895" mass="97538" checksum="05046265F8EF64D9" modified="2017-01-18" version="1">MSATEPTNEKVDKIVSDDEDEDIDQLVADLQSNPGAGDEEEEEENDSSFKAVPEELLQTDPRVGLTDDEVTKRRKRYGLNQMAEEQENLVLKFVMFFVGPIQFVMEAAAVLAAGLEDWVDFGVICALLLLNAFVGFIQEYQAGSIVDELKKTLANSALVVRNGQLVEIPANEVVPGDILQLEDGTVIPTDGRIVSEDCLLQVDQSAITGESLAVDKRSGDSCYSSSTVKTGEAFMIVTATGDSTFVGRAAALVNKASAGTGHFTEVLNGIGTTLLVFVIVTLLVVWVACFYRTVRIVPILRYTLAITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVEPDDLMLTACLAASRKKKGLDAIDKAFLKSLINYPRAKAALPKYKVIEFQPFDPVSKKVTAIVESPEGERIICVKGAPLFVLKTVEDDHPIPEDVHENYQNTVAEFASRGFRSLGVARKRGEGHWEILGIMPCMDPPRDDTAATVNEARRLGLRVKMLTGDAVGIAKETCRQLGLGTNIYDADRLGLSGGGDMAGSEIADFVENADGFAEVFPQHKYNAVEILQSRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLELFLGLWIAILNRSLDINLIVFIAIFADVATLAIAYDNAPYDPKPVKWNLPRLWGMSIVLGVILAIGTWITLTTMLLPKGGIIQNFGGLDGILFLQISLTENWLIFVTRAQGPFWSSIPSWQLSGAVLIVDIIATCFTLFGWWSQNWTDIVTVVRTWIWSFGVFCVMGGAYYLMSTSEAFDNFCNGRKPQQHTDKRSLEDFLVSMQRVSTQHEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ04</accession>
    <name>A0A1D8PJ04_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C300790WA</name>
        <name evidence="8" type="ordered locus">orf19.12831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717753.2">
        <property type="nucleotide sequence ID" value="XM_712660.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PJ04"/>
    <dbReference type="STRING" id="237561.A0A1D8PJ04"/>
    <dbReference type="GeneID" id="3648186"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300790WA"/>
    <dbReference type="CGD" id="CAL0000187386">
        <property type="gene designation" value="orf19.12831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00790W_A"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJ04"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
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        </source>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="69" mass="7863" checksum="7BDC8FF406CDDA62" modified="2017-01-18" version="1">MPSNLFSNYFYRQRQLPQHQQNDINTSILEPTTAGTVDANPNPVISNLINQERPKHNYHKSSDNLAIGL</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C302390WA"/>
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    <proteinExistence type="predicted"/>
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            <begin position="356"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="541" mass="61181" checksum="26188EC56F17D0BB" modified="2017-01-18" version="1">MATYAKRRNGNGGGNTFKRARLSTSNSNNNNNNNNNNNNSSTSTSTLLSPISKRSITKSINNKINNNKNGQGQLYDDFLEIYNFQTDTKSNEDKSTNSQLDLFEMPDIDGDKSISRPKKISDDSITGAYKKKVTYNRSNKSKSKSNSNSNSNSNSNSNSNSNSNSNSNSKPKPKPRPKPKPKPVSKNISKINQTSNINPWNELLDNIEESTVYLPKISLIDDENESDENDQVQIGVNKAQEGGETITTTSIINLPILLNFDNEGEDEEEEEEENLQQQLIQSRSLSTSPSNSNSNSNSSKPNKTYAQDRSYLILDQSYIDVKQELGESISRKHDFDNNNNDNTEEEEEKEKEDINNNKLLSSSSSSGGGRVINVHDFKIKSEFKINPILQDIIDGLLSNSFNLQLSSLLEIISKKKKLSISTDTTDMTDMTDMRKGIIDIIIQYVLPLIDSNNKLINWLSSKIIFDIWKSTTIKLKEVEVKVEEKEEKRISFRDTFVNSIQNRLNDIEKNLNLEEENIDELKIIINQIPKIYRSMINELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJQ4</accession>
    <name>A0A1D8PJQ4_CANAL</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C303440CA</name>
        <name evidence="8" type="ordered locus">orf19.7974</name>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720036.2">
        <property type="nucleotide sequence ID" value="XM_714943.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJQ4"/>
    <dbReference type="GeneID" id="3638356"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303440CA"/>
    <dbReference type="CGD" id="CAL0000181961">
        <property type="gene designation" value="orf19.7974"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03440C_A"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Magee P.T."/>
            </authorList>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_711522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKC2"/>
    <dbReference type="FunCoup" id="A0A1D8PKC2">
        <property type="interactions" value="778"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKC2"/>
    <dbReference type="GeneID" id="3641743"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305930WA"/>
    <dbReference type="CGD" id="CAL0000200226">
        <property type="gene designation" value="CTA4"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QRPQ">
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    <dbReference type="OMA" id="CANENII"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cellular response to nitrosative stress"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
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    </dbReference>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000304"/>
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        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="841"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000200226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1016" mass="117165" checksum="247494DD8B73B48D" modified="2017-01-18" version="1">MTSEHKVSRNKPSLSCTNCRKRKTKCDRKQPCSACVKKINLSYTCAYDTPPKQFAINSDTPPTEYPARKRHKPETIDDAENPVQQELARLRKRIIELETSLQHAHTPKTPPENKNYPRNKPILSPTSSTCPNPIVNDEEIINFYEGYTPIQVKRNIRRVNYGPLSWIALMRKDPALNLAWKVLCSKDSYCIITNRWPRLTSENNALINISHNPEDEKNSNYMDKIFQKRVLEFEGYDEFVPYRSLYGRKESDTTNTEQPTTSDKSTSKPSSTTTTNPGPRLNFTQISLAKSIFDGRINPELHLIEKIKQIVPKRKVFWTLMDRFFTDIYPYFPFVDEESFKKELSRIFGTRTYTDLPFESIRIEKKLDLANIAICFILLRLTYLSFFNNRNCVNEFIMNSEEETVAKYIMQNPINLSTIEVANSCIQCFQFTRKSNITVFQAMLYMRIYRNCAPEESDGIDGGDSQVATALLVQMAYSLGLNREPDKFDVCNDEKVNHLGRKMWSFLMRSDLTQCYTLGNPTSIDPRNYDVRPPFVNDNNSNIEDREMEIAIVETFVYLNSELDLMRKMLDHVLDINNGAKINDLTRDVHDFEVILHDFFNVLGNVNAGKVKTDRESVIQYYHVIKLKIFLSMKTALVSLYFHIYLHYEKRFDSELSFFYLSKMYLIIRDDLIPAIGHTLIGKYSSKALVLNPNMQLALHKINQINLSCLIRVSYLVHMFEQKPNHEESMANDIVYSEHFNKLKSLMTNVRRTGDFVRVIMERIGSRYYYSWRIAKAHVGLFKMLSQPENYDKQLSGIRKLKSFQFTPKQLDELDNSIRILGKCAEKLVFYEDSVGMSPDFEMPFKPSEGDGNEKDQNQNDSKTTTTTTTTTTSDSTGISITPENNASAIVTPYSSLASPRLHLDNISNDYVDQMWFSMMAMKYDTLEPMGNNPDCQNCNSDDPNACPVSYNTRDNGVLGGTGGQLLTQQKQMTAQEQLAQQEITRQMQFGNENGYNNGFFLNSGFDLMDDGYFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKK4</accession>
    <name>A0A1D8PKK4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C306710WA</name>
        <name evidence="6" type="ordered locus">orf19.14124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719924.2">
        <property type="nucleotide sequence ID" value="XM_714831.2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKK4"/>
    <dbReference type="GeneID" id="3638448"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306710WA"/>
    <dbReference type="CGD" id="CAL0000187243">
        <property type="gene designation" value="orf19.14124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06710W_A"/>
    <dbReference type="eggNOG" id="KOG1288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKK4"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000187243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="663" mass="74608" checksum="EAB5FA60E442A4B0" modified="2017-01-18" version="1">MILKSMGLHYLYYLVMIATKSLSDNYPSIXLRKERKVSINQWVQIVEDLIVLQATVAVAANFTQMVLPKTEKGKGIFKLKKPFKNEKPAEKYIDLYPIQMSSVAQLDNGQSVMSTNFDTYTLILQLGYILSTVDEWEINNYRVRVIVFVEFSNEVADEKERLAGLLSSLRIDAEIRVICLENANLDSYNYMIKGYTKSQSNKTQYDKVDRVLACDQWWKNLSKARETLREIEKRKTLGKQKLRIIPTRTDSNSSLLPETFQPLNLTSRSPQGVQVQGLKNNRRYTLSNLQEQGMSLSFNLRAANSTTGKDLLYADSIVDSSDSESEDSSSVATSNTTANLGYVSSRDNSYVNLASSQATLENTQRGDLPKVKNTLKEQNVYSRTHTPEILSSRSSVINLRPNFSSVKIPTAKINDEAEDGDDQEEDEEEEGAETDNVQGKEEDETNKETAEKGSILIKDKQSKTKDRSKQSIQFVADEPPKDLSVNPESSQSNQKGGKPKTKNLIVNDDEIIHHMETPQFLAAEDDDETDFLQMSLRDSKFPSCGPSSARSEVYKQKPTLSTNQSADSERTITRKQLQEELKNLTFNDIPAKGQHLVLNELMSRNSPSDKTHIIFSTLPAPSNGTHLNDTDSFDYTNNLAIWLDDLPPILLVNSQTVTVTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL97</accession>
    <name>A0A1D8PL97_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C401130CA</name>
        <name evidence="7" type="ordered locus">orf19.4677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12 13" key="2">
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                <person name="Martchenko M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW29721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_715539.2"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C503010WA"/>
    <dbReference type="CGD" id="CAL0000192732">
        <property type="gene designation" value="SNU66"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNL9"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="651"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000192732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="673" mass="76896" checksum="4B12514AF7AB3DEC" modified="2017-01-18" version="1">MSEEISLSLEETNKLRIKAGLSPIPTTSSQSNEKVREVISLSIEETNKLRQKIGLPLLPTTTTTNISSDSTEYKNYEDYERERLQNLKNNQLIERINNAKFNSNKRKFLTNETIIDNAEDLDTDDWLNNLGESTESSKPHKKQKTTIVKSNQNDTGPTTTIIGHTTKELQSLGNNEILTLKDTDLINDDDEDGTGSILMNQDLSNKAKLKRNLAERKEAENIKFNGRHYRRNNKEEEEEEEEEFNDIDGLLTNDKVIMSGSTIDLSSNTAKPPPPPKDKKKNMMAITNLFEDLDNVTLSNNNNIKSNVPIKMKKIKKKKDNNKKKSNKLKLLDDSIKPVELSVESNIGDDDDIDDIENQLSNSISNLRTKKLQTRLEFTPEQLAEEISANKRWEFERKLEQENLKNNNNNNNVYNDTIGFLNNLETNILSESGEVEVTANINEESADDDDKDDVKQQEVESKQTNPGVYSIVEEKQKEDEAPKFSGGLAETLKFLKSRNILDPESITTTNEELRQQELAREEAIKKSELLKMKISIEERILKEELSKDKSYIRMPKIERSGYFEKLLDTRLKQKGIIIDNNTGTTTKKTNSGMVQNNLKIYNPKVELTYKDELGNVLNTKQAYKQLSHKYHGTGLDKNKKKQEQLKKKQQQQRGSKSTNISTTSTTVTERVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP91</accession>
    <name>A0A1D8PP91_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C505510CA</name>
        <name evidence="2" type="ordered locus">orf19.11537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000184194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="103" mass="11762" checksum="A7E321AF626B77B0" modified="2017-01-18" version="1">MSNAIDFGVVDDSEEPAVYTTFLPRPISALARVNLVLHEHPVVKYKTITRVRGGDEPLMSGEEERYGTEDERDTEKPLVEHNYDWSLQYLPGLQFGVVSIRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPF4</accession>
    <name>A0A1D8PPF4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C600730WA</name>
        <name evidence="2" type="ordered locus">orf19.11139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711327.1">
        <property type="nucleotide sequence ID" value="XM_706235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPF4"/>
    <dbReference type="GeneID" id="3647070"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600730WA"/>
    <dbReference type="CGD" id="CAL0000176514">
        <property type="gene designation" value="orf19.11139"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00730W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPF4"/>
    <dbReference type="OrthoDB" id="4092221at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000176514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="638" mass="73305" checksum="7BE18AB6938BC1F6" modified="2017-01-18" version="1">MIEPQDLQRKVNLFKRSPQKPIYKQNLLMDHEEPQYIIDNYKNSYLKIGGNGDGLDNSGNTNIMPLAANAKSIPMSTDTDSLILANAFYIFMTIIVLLILLSSISFGIREYSFAFRRRIKSSTNEALKLNNWNNTNKKANRPSPLCNKIDKAQVREATNTETNNQHETPMSSKNNAISGMTQFTDKEPKIENAQQWCYKEDTSPNYNVPSSHTESEKVYYENEYDSGLTDKSITKFTKKQTIPSFVTIQPKSIYSIDSLMALDKTKAMIGGVLNNVFKYKQKQKIPMSCLLNCTIVLPRTTFDNAWKAAKVIRDAENEIITSSCKISKKLSLLRILSIGKSFELLDNPNIFLEAFNDCIENLVDMGLVFTMMFDSSVVLKLLLIESLLTYSWSHYRFYDFDAKSNLVKLQFSNWNLPHPIVQTRNTIFKILCNLQLGLDTIFAESKEMENDNELKLGLVIRESINHSVCNDYIGYVPMIAQAIDISNIDRNKFFFYEILKLLIVKHGNCCMKEYIQESNIELKTLVQYGLSDDQHLVIQDKAKEIFQLLSRHDENIFMWFNDINHSKIHIDSAVPLSTEHTEKYFSAPLFKQQPPILEEPSSGSTFDSFSHSWKMGILSSDLKFHKNIDNRQSRVVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPM2</accession>
    <name>A0A1D8PPM2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C601470WA</name>
        <name evidence="1" type="ordered locus">orf19.10941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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    <sequence length="229" mass="25866" checksum="2D03A2332023994D" modified="2017-01-18" version="1">MPSSERDTLLAESKTILKSVTNWKPGKQFKSNVIPETITTSTYSTTNIKDNQFWCARESLIPSTYKQKVIDCLIGTANIGSTHSDHEVNYVEEFDSLKISNVTEYPDGGWSYELHANYKFGTIGISNRMFYESVHIYKFDKSNQTEEDDKDTNCAYIISVPIDGPTGNFVIGKYHSIEKISWSDNKDSDLKWIMATTSDAGGYLPRWLTNMILPGAISNDVPSVLKYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQA8</accession>
    <name>A0A1D8PQA8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C603990CA</name>
        <name evidence="2" type="ordered locus">orf19.13197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710014.2">
        <property type="nucleotide sequence ID" value="XM_704922.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQA8"/>
    <dbReference type="STRING" id="237561.A0A1D8PQA8"/>
    <dbReference type="GeneID" id="3640271"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603990CA"/>
    <dbReference type="CGD" id="CAL0000196240">
        <property type="gene designation" value="orf19.13197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03990C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PQA8"/>
    <dbReference type="OrthoDB" id="4022940at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000196240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="512" mass="56817" checksum="1B94C75AD8411FAF" modified="2017-01-18" version="1">MSEVPNQESPGSSIFKQSNASTSTKIHGAPSSSQIANVDFNTLRKLNTNTSFSSNLTNSTTKTSNALSRLFTRNKSSSNISVHPSSSDDDSSPKTLRESTSPSESSKSVSGNKLRIAKKLKFPKNQSSRKPDLFLDTSSTISEDSSSFRKIITGNSLNEMNKSRKSSMSSPMSTTFHSLFHRSHHSGSNLQQDNNSAATGTTPLSGKFDDFSKPSKTTLCLSSNSSNSIISNPELAQIYNFTNPNISIEDGETNLDHTNSSFLDIHKKMLVPADSFIQNKLNKYHQTEVGLGIYESELDHDKDSKIYSNLYHYLRSLFTPSFTISDSGQKGKRRPILSTSVEEIANFVKESFCLHQPNHERSFRSKTRSSVSSLGREKVEDFDYRQLSNLFEKLMALLNHNLQTAEPSDISLQALILNAWKYYNAYVRFYLLSIFQPLQLHLNELSTRGHNGSKITRIDDLLLVSFRKVFITEQGIGSGDRETSQFLGNAESEDLTGNGLLTSTLAVLSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQD4</accession>
    <name>A0A1D8PQD4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C604280WA</name>
        <name evidence="11" type="ordered locus">orf19.8686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712098.1">
        <property type="nucleotide sequence ID" value="XM_707005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQD4"/>
    <dbReference type="SMR" id="A0A1D8PQD4"/>
    <dbReference type="FunCoup" id="A0A1D8PQD4">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQD4"/>
    <dbReference type="GeneID" id="3646279"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604280WA"/>
    <dbReference type="CGD" id="CAL0000174534">
        <property type="gene designation" value="orf19.8686"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04280W_A"/>
    <dbReference type="eggNOG" id="KOG0418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQD4"/>
    <dbReference type="OMA" id="HWTFVYA"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000080">
        <property type="entry name" value="UBC1p Ubiquitin-conjugating enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000174534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="232" mass="25457" checksum="262C8A00298B6D14" modified="2017-01-18" version="1">MSRVKRIAKELEECRQDTQSGVSLNLNNENDLTHLTGYFKGPPGTPYEGGLFQVAIDIPQEYPFKPPQMKFITKIYHPNISSVTGAICLDILKDAWTPILTLKSSLISLQSLLQSPEPSDPQDAEVAKHYLSNKSGFEETAAYWTKIYASDGVDGSGSGSGSSNNNGGGAKLSDSALYGIDDEIVGQYESMGFPRDKTIQVLRRMGIKSFKGVGNKSELENKILEELLRECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQI5</accession>
    <name>A0A1D8PQI5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C700220WA</name>
        <name evidence="2" type="ordered locus">orf19.7102</name>
    </gene>
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                <person name="Dungan J."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <name evidence="2" type="ordered locus">orf19.10755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717936.2">
        <property type="nucleotide sequence ID" value="XM_712843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRW2"/>
    <dbReference type="GeneID" id="3640379"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01090WA"/>
    <dbReference type="CGD" id="CAL0000183189">
        <property type="gene designation" value="orf19.10755"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01090W_A"/>
    <dbReference type="eggNOG" id="ENOG502R9MD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRW2"/>
    <dbReference type="OMA" id="DMHRLQN"/>
    <dbReference type="OrthoDB" id="4096032at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000183189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="848" mass="97959" checksum="9223AC583197E166" modified="2017-01-18" version="1">MPPPSTPNPRTSNVLPTNQEQSEDIPSSSSSPNFSRYEEANTLDSMQRFRNASNTTNNTSSFSRLNSINLVSDYMYRNLHAEYNDHAINEPDAHFRSRILRHISDMHRLQNHFNELINTREQRNTLDHELAINTIPVQLRNLSRELTRNDNREAYYIETTDEDDQSFQEDDDPNVIYYSDNHDESDVIEVDDDESALSDDASAALRQDVRNNERLIVTSARNNSALYPYRSSLLGTTSALPLRRQNAIRIRQPPNKQGEEHAKSTNKDGNLITEVLNEEANALRTDISKFYQALQASGCFQGESPLFEKNYHDHGANFRKLYLTGPNGGSAMITEYRLSNLDQRMDAYLQSRRNRSLWQKTTLPIPPPPTLDKKRSRGIAKRTSKKQKLIHNTDDEVAKYVDDAPSNFPKTRCTYSKTEKEAIMNGLPSSLLESGSSYSVGISADPLYRCDVNFTDVNKIIHGVFSFTPEEKSPLLSVLLKLHNFTKFFCGFNDYAQNLPRSKILVRKLNVLDRISIDNKVHFNNFKTRGVNIPFNGHLVDFRNRDLRFLNYDSNESFSSRFKTNRVRLQLLEWMKLHPFIQFKENYFLSFLREVNDSMGYICEAKMKKSTKSQALNTVKDFISNLHELTKDFSFIKDTNSPLLEEQRKQKQCSRRYKDLFVDEWERYLTGKLCQNITTKESNTLINVQLNFILFVLEVDLSKFLDNFMDFIFQHCDNNDYINNYRKVYRNILSDEAKESDNYRAILICSIDRKTGAIEIHNTLPYLHYKDRSIKNTNFILSSDHNLSTYSSRNTYVYDDFEIFEGENVPLNSGTFNTSINLDGSTEAVVDSNLTGTVKLGTPVCDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSA9</accession>
    <name>A0A1D8PSA9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">PGM2</name>
        <name evidence="19" type="ordered locus">CAALFM_CR02820WA</name>
        <name evidence="18" type="ordered locus">orf19.10359</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="4">
        <citation type="submission" date="2021-08" db="PDB data bank">
            <title>Targeting an essential step in the biosynthetic pathway of uridine diphosphate glucose in Aspergillus fumigatus.</title>
            <authorList>
                <person name="Yan K."/>
                <person name="Stanley M."/>
                <person name="Kowalski B."/>
                <person name="Raimi O.G."/>
                <person name="Ferenbach A.T."/>
                <person name="Wei P."/>
                <person name="Yuan H."/>
                <person name="Fang W."/>
                <person name="van Aalten D.M.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715772.2">
        <property type="nucleotide sequence ID" value="XM_710679.2"/>
    </dbReference>
    <dbReference type="PDB" id="7PIZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="B/C=1-560"/>
    </dbReference>
    <dbReference type="PDB" id="7PJC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.11 A"/>
        <property type="chains" value="A/B=1-560"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSA9"/>
    <dbReference type="SMR" id="A0A1D8PSA9"/>
    <dbReference type="FunCoup" id="A0A1D8PSA9">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSA9"/>
    <dbReference type="GeneID" id="3642562"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02820WA"/>
    <dbReference type="CGD" id="CAL0000201506">
        <property type="gene designation" value="PGM2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02820W_A"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSA9"/>
    <dbReference type="OMA" id="WIQDRAN"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019388">
        <property type="term" value="P:galactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019255">
        <property type="term" value="P:glucose 1-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="21 22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="17"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="188"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="307"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000201506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="7PIZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="7PJC"/>
        </source>
    </evidence>
    <sequence length="560" mass="61842" checksum="C2445A38F4F7457D" modified="2017-01-18" version="1">MSELSIKTIETKPFQDQKPGTSGLRKKVTVFQQPHYTENFIQSILDAIPEGSQGSTLVIGGDGRFYNDVVIQLIIKIAAANGVKKLILGQNGILSTPATSHVIRIKQATGGIILTASHNPGGPQNDLGIKYNLGNGGPAPESVTNKIYEISKQINQYKLIELPNVDLSKIGTIVEGPIEIEIIDSTKDYVDMLKSIFDFPLIKSFIDKATKEQDFKVLFDALNGVTGPYGYEIFVNELGLPESSIQNYKPLPDFGGLHPDPNLTYAHTLVERVDKENIAFGAASDGDGDRNMIYGAGTFVSPGDSVAIISEYADSIPYFQKQGVYGLARSMPTSGAIDLVAANKNLQCYEVPTGWKFFCSLFDAKKLSICGEESFGTGSNHIREKDGLWAIVAWLNVLAGYNKQNPQSKTSIEIVQNSFWEKYGRTFFTRYDYENVSSEGAQKLIDLLQSIVNEKSVGDELAPGYIIKQADNFSYTDLDGSVSSNQGLFIKFDNGLRFIVRLSGTGSSGATVRLYLEKHCDDKSKYHLKVDEYLTNEIQFVLELLKFKQFLNKEEPDVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSI8</accession>
    <name>A0A1D8PSI8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">SMC1</name>
        <name evidence="14" type="ordered locus">CAALFM_CR03680CA</name>
        <name evidence="13" type="ordered locus">orf19.11845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715143.2">
        <property type="nucleotide sequence ID" value="XM_710050.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSI8"/>
    <dbReference type="SMR" id="A0A1D8PSI8"/>
    <dbReference type="FunCoup" id="A0A1D8PSI8">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSI8"/>
    <dbReference type="GeneID" id="3643221"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03680CA"/>
    <dbReference type="CGD" id="CAL0000179192">
        <property type="gene designation" value="SMC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03680C_A"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSI8"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="526"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="174"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="832"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1024"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000179192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW31106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1240" mass="141783" checksum="5BB751B99BD50B1E" modified="2017-01-18" version="1">MGRLIGLELFNFKSYKGKSIIGFGSSYFTSIIGPNGAGKSNMMDAISFVLGVNSYHLRSQNLKDLIYRGRRNIDTDSTTLDAIEQDPTSAYVMATYEKDDGEILKLKRTITASGNSDYQINGQSVTMLNYSMVLKQENILIKARNFLVFQGDVETIASQNPKDLTKLIETISGSNEYINEYERLKEEHEKAHELTTSVFSRKRTLNSESKQYKEQMAEQRQFEEKIITKNDTVKKINLYKLFHNEKKHNQLKDEIKSKNEELKLAKKELSNKEKTYKSIMTDYSSSVLNAKKQKQQTEAAQQKIDSTKRELIPVEANQRSLSNKINFHKLKVGDLVKDIARQKTQVSSVERQLRDAQRMFDDFQAKIAAAVASSTNISPEAQKEYEELRSKFLAENGSELEEQISLLLNNKDSLNSAKSNLENQKTNAENRIAELESIVATDLKSKLHDVSNEINEVLDKKSDKVEARNALIKQKDEFNHEELKLNTRLRDVLVKLDELASQQRESNKQKKLRENVATLKRLFPQGAIKGLVYELVRPTQQKYESALATLLGPNFDSIIVESSAVAYKCIDILKERRAGVATFIPLDSIETDIINLSHLRSIHPSALPGVDIIEYQDKSLEPAVNYIIGNTVVVDTIDTARNLKWQSNTRFDNKIVTLQGSVIHKSGLMTGGQQQQKSSASLSWSKQEWTKLNELKEELNQKIFKLQEKRPKDLEINLLAEEIGALDDKLPVLRNQKTSIERIIKDRESEIEFQTGLFKGFDKSIQEKMNEITKINGKIDKVNEKMKSSKDLIFAEFCEKYGFINGIEDYENMHGSTLRVRAKERAQFSKTISVLQNKLDFEKERLKETKDRRKSIESLIVDLEDDLAKVLTEKKKLEESLDKEEAEYEVLQTEISQFDDSMQSQLKTSKSIESDLDDSKSLVSTLVKEITQIEENLLKTDSERANVLRNCKIQNINLPLIDGDLDSISVGENLESSIKEVYKIELDYEMLEERFKEVFNNKLESELEVTLQNTISDLEKLTPNAKAIERLREVETKLRNYDKEYNVARQKERQVIERFKKVQEKRYDKFMDAFNHISGCIDSIYKELTKSAMSPLGGSAYLTLEDEDSPFLSGIKYHAMPPMKRFRDMELLSGGEKTMAALALLFAIHSYQPSPFFVLDEIDAALDNANVARIGNYIKKYAGPNFQFIVISLKNSLFEKSDALVGIYREQRENSSKTVTLDLREYPDDDVPLSTVTATT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT64</accession>
    <name>ZCF19_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc cluster transcription factor ZCF19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ZCF19</name>
        <name type="ordered locus">CAALFM_CR06240CA</name>
        <name type="ordered locus">orf19.11357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probably acts as a transcritpion regulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713501.2">
        <property type="nucleotide sequence ID" value="XM_708408.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT64"/>
    <dbReference type="STRING" id="237561.A0A1D8PT64"/>
    <dbReference type="EnsemblFungi" id="CR_06240C_A-T">
        <property type="protein sequence ID" value="CR_06240C_A-T-p1"/>
        <property type="gene ID" value="CR_06240C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644869"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06240CA"/>
    <dbReference type="CGD" id="CAL0000179648">
        <property type="gene designation" value="ZCF19"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06240C_A"/>
    <dbReference type="eggNOG" id="ENOG502QUEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT64"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463348" description="Zinc cluster transcription factor ZCF19">
        <location>
            <begin position="1"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 2">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000179648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="619" mass="71529" checksum="91DCC3C047873A4E" modified="2017-01-18" version="1">MVSIPPDTTPGTSKKRKSTTTNDPSPEKDKTRKYAQASRTLKACELCRKQKTRCFRSPENPNSCLRCRFLSKTCSFENEETEGEISGMLPFNLSNQETTKKIDMIHDGINQILNYMKNGARTEDAKLLLDASESMKDRSNSIVNANDQNIPQFDSFKSVSSASPIAILQQLFPHQCNTSITNPMLQNTTLIQKEDVITLGILSEHEVTELISNFRRNYGRWVSFPSSVSTENLIVQIKEKSDLLLTSCCLVSFRYYKYKGPNNRSMECQLLTQRLTQDLNNSLVKYTSFGTCLGQVEFLQALVILSIYSKSLSKLDHSLNLDPWFLSNIGLSTFITKTALIDDFKEIDDETVEIQGETYNKLTILRIYNHLCLAHISNCIFSGRMCILDSNRVEKCATTLSLLNATNFDGRMVSEIGLLFITYKYLQNVSEIDSYQKLDHIFEKVVLDIKSWFVQWEYLFSQPALHFLEFNYNFCSMLVYYVYCFTRLKLLGEVAHHGVLDEDIFTDVFQKIDNEKLLETMYEYCLQVISHTNNIENDSYFAYLSDQIHFTFYFCCVFMIKLQKVMTNKDMLPAKNRKRLINVIQSLIDKFERISTDYPHDIIVTYKNNLETCLKENFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTF4</accession>
    <name>A0A1D8PTF4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_CR07190WA</name>
        <name evidence="7" type="ordered locus">orf19.730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713089.2">
        <property type="nucleotide sequence ID" value="XM_707996.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTF4"/>
    <dbReference type="FunCoup" id="A0A1D8PTF4">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="GeneID" id="3645269"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07190WA"/>
    <dbReference type="CGD" id="CAL0000200127">
        <property type="gene designation" value="orf19.730"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07190W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTF4"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04436">
        <property type="entry name" value="DEP_fRgd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04399">
        <property type="entry name" value="RhoGAP_fRGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000169">
        <property type="entry name" value="Rgd3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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            <dbReference type="PubMed" id="17419877"/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="nucleotide sequence ID" value="XM_711129.2"/>
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    <dbReference type="SMR" id="A0A1D8PTN6"/>
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    <dbReference type="eggNOG" id="KOG0054">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:bilirubin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
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    </dbReference>
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        <property type="entry name" value="ABCC_MRP_domain1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, putative"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
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        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="TMD0_ABC"/>
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        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
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    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="31"/>
            <end position="52"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTT5</accession>
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        <name evidence="1" type="ordered locus">orf19.6834.10</name>
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    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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            <dbReference type="CGD" id="CAL0000180236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31553.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="89" mass="10310" checksum="88D997F068E6E513" modified="2017-01-18" version="1">MQNTKSDLKPFPFNNFTYFFTLFSKFFSSFHHCTCSLSVSRQYLALDGIYHPLRAAFPNNSTRRRNFTQTRVISSHGILTLCDVSFQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PUD2</accession>
    <name>A0A1D8PUD2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">ATP16</name>
        <name evidence="17" type="ordered locus">CAALFM_CR10850CA</name>
        <name evidence="16" type="ordered locus">orf19.7678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719436.1">
        <property type="nucleotide sequence ID" value="XM_714343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PUD2"/>
    <dbReference type="SMR" id="A0A1D8PUD2"/>
    <dbReference type="FunCoup" id="A0A1D8PUD2">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PUD2"/>
    <dbReference type="GeneID" id="3638963"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10850CA"/>
    <dbReference type="CGD" id="CAL0000197920">
        <property type="gene designation" value="ATP16"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10850C_A"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PUD2"/>
    <dbReference type="OMA" id="HQTLYSE"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="PHI-base" id="PHI:11818"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
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        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000197920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW31733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="161" mass="17582" checksum="1E86DAF57EDC7292" modified="2017-01-18" version="1">MFRQVFRQVTKQSFTGVKRTYATEAAVSTDALKLSLALPHQTLYNDSEVQQVNLPSVNGDLGILANHIPIVEQLRPGLLEIISKNGDSDQYFVSGGIAMVQPGNKLTISAIEAFKTDQIDLSAVKNLIADAQKRAESSDEKVAAEANIELEVLDALQHFTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>P83784</accession>
    <accession>A0A1D8PHW3</accession>
    <accession>Q59U57</accession>
    <name>HSP77_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein SSC1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cytoplasmic antigenic protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>mtHSP70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SSC1</name>
        <name type="ordered locus">CAALFM_C207380WA</name>
        <name type="ORF">CaO19.1896</name>
        <name type="ORF">CaO19.9452</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proteomics" volume="4" first="3084" last="3106">
            <title>Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Abian J."/>
                <person name="Carrascal M."/>
                <person name="Sanchez M."/>
                <person name="Nombela C."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="15378761"/>
            <dbReference type="DOI" id="10.1002/pmic.200400903"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 591-597</scope>
        <scope>ANTIGENICITY</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
            <tissue>Protoplast</tissue>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713153.1">
        <property type="nucleotide sequence ID" value="XM_708060.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P83784"/>
    <dbReference type="SMR" id="P83784"/>
    <dbReference type="BioGRID" id="1228280">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="P83784">
        <property type="interactions" value="1737"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P83784"/>
    <dbReference type="EnsemblFungi" id="C2_07380W_A-T">
        <property type="protein sequence ID" value="C2_07380W_A-T-p1"/>
        <property type="gene ID" value="C2_07380W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645232"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207380WA"/>
    <dbReference type="CGD" id="CAL0000178007">
        <property type="gene designation" value="SSC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07380W_A"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="P83784"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="PRO" id="PR:P83784"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000089306" description="Heat shock protein SSC1, mitochondrial">
        <location>
            <begin position="24"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="560"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="648" mass="69748" checksum="FDE4AAEBEF3D1DA3" modified="2011-10-19" version="2" precursor="true">MLSARNSLKNISRQFPKALTRAQSTAAAPTGPVIGIDLGTTNSAVAVMEGKTPKILENSEGGRTTPSIVAFTKDGERLVGIPAKRQAVVNPSDTLFATKRLIGRRYEDPEVQRDINQVPYKIVKHGNGDAWLEARGEQYSPQQIGGFILNKMKETAEAALSKKVNSAVVTCPAYFNDAQRQATKDAGKIVGLNVLRVINEPTAAALAYGLEKKDGEVVAVFDLGGGTFDVSILDIGAGVFEVKSTNGDTHLGGEDFDIALVRYIVDAFKKESGIDLEKDKMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINQKISRAQFEQLVEPLIKKTIEPCKKALKDAGLSTSDVSEVILVGGMSRMPKVVETVKSIFGKEPSKGINPDEAVAMGAAIQGGILAGEVKDVVLLDVTPLSLGIETMGGVFARLISRNTTIPAKKSQIFSTAAAGQTSVEIRVFQGERELTRDNKLIGNFTLSGIPPAPKGVPQIEVTFDIDTDGIIKVSARDKATNKDASITVAGSSGLSDAEIEKMVNDAEKFAESDKARREAIEFANRADQLCNDTENSLNEHKEKLSSESVQKVQDQIQQLREIVLKAQAGEEVSPEELKQKTEELQNEAINLFKDLYKDGGESSGSSEQPKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2025-06-18" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q3MNT0</accession>
    <accession>A0A1D8PRK1</accession>
    <accession>Q5A0G3</accession>
    <name>SPT6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcription elongation factor SPT6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Chromatin elongation factor SPT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SPT6</name>
        <name type="ordered locus">CAALFM_C704300WA</name>
        <name type="ORF">CaJ7.0509</name>
        <name type="ORF">CaO19.7136</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715187.1">
        <property type="nucleotide sequence ID" value="XM_710094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q3MNT0"/>
    <dbReference type="SMR" id="Q3MNT0"/>
    <dbReference type="BioGRID" id="1226265">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q3MNT0">
        <property type="interactions" value="1269"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q3MNT0"/>
    <dbReference type="EnsemblFungi" id="C7_04300W_A-T">
        <property type="protein sequence ID" value="C7_04300W_A-T-p1"/>
        <property type="gene ID" value="C7_04300W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643171"/>
    <dbReference type="KEGG" id="cal:CAALFM_C704300WA"/>
    <dbReference type="CGD" id="CAL0000194756">
        <property type="gene designation" value="SPT6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_04300W_A"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="InParanoid" id="Q3MNT0"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001073">
        <property type="term" value="F:transcription antitermination factor activity, DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0727">SH2 domain</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <feature type="chain" id="PRO_0000238571" description="Transcription elongation factor SPT6">
        <location>
            <begin position="1"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1401" mass="162067" checksum="B88983308D660B6C" modified="2005-10-25" version="1">MMKKKISAKKKNQQQQQLHQPTMSEVTEEERTRYEEEEDVRDSPSDSSEESEDDEEEIQKVREGFIVDDEEDEVQTKKRKSHKRKRDKERPHYDDALDDDDLELLLENSGLKRGSSSSGKFKRLKRKQIEDDEDEIESQDHQGEQQLRDIFSDDEEVEEEAAPRIMDEFDGFIEEDDFSDEDEQTRLERREQRKKKKQGPRIDTSNLSNVDRQSLSELFEVFGDGNEYDWALEAQELEDAGAIDKEEPASLDEVFEHSELKERMLTEEDNLIRIIDVPERYQMYRSALTYIDLDDEELELEKTWVANTLLKEKKAFLRDDWVEPFKQCVGQVVQFVSKENLEVPFIWNHRRDYLEYVDPDAPIPGSVRELMISEDDVWRIVKLDIEYHSLYEKRLNTEKIIDSLEIDDELVKDIKTLDSMVAIQDMHDYIQFTYSKEIRQREETQNRKHSKFALYERIRENVLYDAVKAYGITAKEFGENVQDQSSKGFEVPYRIHATDDPWESPDDMIERLIQDDEVIFRDEKTARDAVRRTFADEIFYNPKIRHEVRSTYKLYASISVAVTEKGRASIDAHSPFADIKYAINRSPADLIAKPDVLLRMLEAERLGLVVIKVETKDFANWFDCLFNCLKSDGFSDISEKWNQERQAVLRTAISRLCAVVALNTKEDLRRECERLIASKVRHGLLAKIEQAPFTPYGFDIGSKANVLALTFGKGDYDSAVVGVYIKHDGKVSRFFKSTENPSRNRETEDAFKGQLKQFFDEDETPDVVVVSGYNANTKRLHDVVYNFVSEYGISVKSEFDDGSSQLVKVIWGQDETARLYQNSERAKKEFPDKPTLVKYAISLGRYLQDPLLEYITLGDDILSLTFHEHQKLISNDLVKEVVESAFVDLVNAVGVDINESVRDSRLAQTLKYVGGLGPRKASGMLRNIAQKLGSVLTTRSQLIEYELTTRTIFINCSAALKISLNKSINVKDFEIEILDTTRIHPEDYQLAMKMAADALDMDEESELHEKGGVIKELLENDPSKLNLLNLNDFANQIYKLTHKLKFRSLQAIRLELIQGFAEIRSPFRILTNEDAFFILTGEKPQMLKNTVIPATITKVTKNHHDPYARIRGLKVVTPSLIQGTIDENAIPRDAEYVQGQVVQAVVLELYTDTFAAVLSLRREDISRAMKGGVVREYGKWDYKAEDEDIKREKAKENAKLAKTRNIQHPFYRNFNYKQAEEYLAPQNVGDYVIRPSSKGASYLTITWKVGNNLFQHLLVEERSRGRFKEYIVDGKTYEDLDQLAFQHIQVIAKNVTDMVRHPKFREGTLSVVHEWLESYTRANPKSSAYVFCYDHKSPGNFLLLFKVNVSAKVVTWHVKTEVGGYELRSSVYPNMLSLCNGFKQAVKMSSQQTKSYNTGYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KG2</accession>
    <accession>A0A1D8PI91</accession>
    <name>RGI1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Respiratory growth induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RGI1</name>
        <name type="ordered locus">CAALFM_C208290CA</name>
        <name type="ORF">CaO19.1354</name>
        <name type="ORF">CaO19.2659</name>
        <name type="ORF">CaO19.8934</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Antimicrob. Agents Chemother." volume="47" first="1220" last="1227">
            <title>Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates.</title>
            <authorList>
                <person name="Rogers P.D."/>
                <person name="Barker K.S."/>
            </authorList>
            <dbReference type="PubMed" id="12654650"/>
            <dbReference type="DOI" id="10.1128/AAC.47.4.1220-1227.2003"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Mol. Biol. Cell" volume="15" first="4490" last="4499">
            <title>Transcription profiling of cyclic AMP signaling in Candida albicans.</title>
            <authorList>
                <person name="Harcus D."/>
                <person name="Nantel A."/>
                <person name="Marcil A."/>
                <person name="Rigby T."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="15269278"/>
            <dbReference type="DOI" id="10.1091/mbc.E04-02-0144"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="Eukaryot. Cell" volume="9" first="1075" last="1086">
            <title>Adaptations of Candida albicans for growth in the mammalian intestinal tract.</title>
            <authorList>
                <person name="Rosenbach A."/>
                <person name="Dignard D."/>
                <person name="Pierce J.V."/>
                <person name="Whiteway M."/>
                <person name="Kumamoto C.A."/>
            </authorList>
            <dbReference type="PubMed" id="20435697"/>
            <dbReference type="DOI" id="10.1128/EC.00034-10"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5">Expression is under the control of RAS1. Up-regulated during colonization of the cecum and invasion of host tissue. Down-regulation correlates with clinical development of fluconazole resistance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RGI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q59KG2"/>
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        <property type="protein sequence ID" value="C2_08290C_A-T-p1"/>
        <property type="gene ID" value="C2_08290C_A"/>
    </dbReference>
    <dbReference type="KEGG" id="cal:CAALFM_C208290CA"/>
    <dbReference type="CGD" id="CAL0000189412">
        <property type="gene designation" value="UCF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08290C_A"/>
    <dbReference type="eggNOG" id="ENOG502S6JA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118207_0_0_1"/>
    <dbReference type="InParanoid" id="Q59KG2"/>
    <dbReference type="OMA" id="HLKYYPP"/>
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    <dbReference type="PRO" id="PR:Q59KG2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:energy reserve metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.40">
        <property type="entry name" value="Respiratory growth induced protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022554">
        <property type="entry name" value="RGI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038235">
        <property type="entry name" value="RGI1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10843">
        <property type="entry name" value="RGI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12654650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15269278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20435697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="201" mass="23654" checksum="759CD16DEC7A47A9" modified="2005-04-26" version="1">MAGKKKSKSEALPLDLDNIKPMDHLQPVPKTRSSSITSIESADEPGTMKQVLLPPTIKEFDELEQFESFVRDETWDNDFDYFHGRLHYYPPFVMKSCQNNLEKIKPTMNKNSKKFRRDLQHHIQKHLIKDLEKCCGYELNFGKGEVVETDNKVTWKFKDETDHGFSKEEEDMYDRHWRLELDVSCTNESAMVDVEYKSIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MG4</accession>
    <name>Q59MG4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">CAALFM_C205810WA</name>
        <name evidence="2" type="ordered locus">orf19.12671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710912.1">
        <property type="nucleotide sequence ID" value="XM_705820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MG4"/>
    <dbReference type="SMR" id="Q59MG4"/>
    <dbReference type="GeneID" id="3647481"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205810WA"/>
    <dbReference type="CGD" id="CAL0000193117">
        <property type="gene designation" value="orf19.12671"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05810W_A"/>
    <dbReference type="eggNOG" id="ENOG502S5HG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023466_0_0_1"/>
    <dbReference type="InParanoid" id="Q59MG4"/>
    <dbReference type="OrthoDB" id="4095763at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021216">
        <property type="entry name" value="DUF2722"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10846">
        <property type="entry name" value="DUF2722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
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        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="77"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="331"/>
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        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000193117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="545" mass="59347" checksum="B0FC85D38D2AB8D3" modified="2005-04-26" version="1">MSSMSVNSLIGKDDESENVKAIPQKRSASSGGSIAEEKAESEPSLQPPFQGQNKRTSIPSVSQLSESIPQHTNTPSLSAYKFPQKQIEDQGLLALLGPNVTSFPFSEETFSNALKLRAEQERTKQEYYRVETANKNLAILQTALRAQMPVNMIPLLCVGNAPELTEEQMKMLIQQATFGTPSVLHPQQQVQQVQQHQQPLHFPTSQQQQQPQQQQQQQQPFVGIQPGLSQEQQIQIIQANQKRMQQELQQKGGSFSQGSPFQKSHTRGGSGGGVGSQQDTFNVNPGPPLSFRFGAGSSTISASGRRPLSPAKIGAAAVANLATPTTPYRGSSSTASTSTRRSAAHHRHSSLPLDTSGISHRLSSVTSGPESSESNRGQGLQSPLTGATSTLQVKPIPAQPLHKQSKSQVQPSQESMTSFQHVIQFHHWKPTTGSPTSSSVGGGSPLKSQTSSHKRRKSSPSIPFQEQQILRPTKEKEFYAESTPKVTFENRNKDEVEMDPDLSIDSSVGEVTESKVDDQANPPKAHHRSESNFAKFPQDKESTAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2025-06-18" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MW2</accession>
    <accession>A0A1D8PTJ8</accession>
    <name>DBP6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP6</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP6</name>
        <name type="ordered locus">CAALFM_CR07750CA</name>
        <name type="ORF">CaO19.11188</name>
        <name type="ORF">CaO19.3704</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711043.2">
        <property type="nucleotide sequence ID" value="XM_705951.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MW2"/>
    <dbReference type="SMR" id="Q59MW2"/>
    <dbReference type="FunCoup" id="Q59MW2">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MW2"/>
    <dbReference type="EnsemblFungi" id="CR_07750C_A-T">
        <property type="protein sequence ID" value="CR_07750C_A-T-p1"/>
        <property type="gene ID" value="CR_07750C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647350"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07750CA"/>
    <dbReference type="CGD" id="CAL0000190599">
        <property type="gene designation" value="DBP6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07750C_A"/>
    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_15_2_1"/>
    <dbReference type="InParanoid" id="Q59MW2"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="PRO" id="PR:Q59MW2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000294659" description="ATP-dependent RNA helicase DBP6">
        <location>
            <begin position="1"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="211"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="430"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="331"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="606" mass="68542" checksum="027CD8780B11A7D8" modified="2017-03-15" version="2">MFSQRYDPLAEENNGSRPADSGFGVSLKKRKLSDDESSDEEEEEEETDESEHESSQDEDINEEEPEEEDEDTNKVDDNMEIDSQPEVDPDYIHKHQAIFNKFKQSTESETIEQDKEEDGEEDANIEQHSLVPLPQPALPRDRKLSSVSTHTKNLDWLTKPQYASPSDKKAFTDFKSSSFMIKNLEKMGFTEAFSVQISVLNMMLPEIEAQKLKPDRVGDILVNASTGSGKTLAYSIPIIESLYRRVVPRVRVIILVPTKPLINQVKSTLLQLSSGTNLQIAALKNDVSINDEKDSLTKSVPDIIVSTPGRLVEHLLNDSINLSSLQYLIIDEADRLLNQSFQNWSNVLLDKIDSQINIAEVWKLSVQKLVFSATLTTDAGKLSSLKFYNPRLIIVNDSKQLVNEIFTVPVTLSEFKIHLGVAKNSLKPLILTKFLISTNKLSNVLIFTKSNESSIRLTELLTSLFQKLSINLKIAFINSTNNRTSIRSKILKQFSNQEVNILITTDLIARGIDVASITDVINYDLPNSSREYVHRVGRTARANQVGYAYSFCFGKGENSWFKKLAHEVSRSKEVENVDLNVKELISDRDEEIYQQALHELQQQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59N76</accession>
    <name>Q59N76_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exomer complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">BUD7</name>
        <name evidence="3" type="ordered locus">CAALFM_C503820CA</name>
        <name evidence="2" type="ordered locus">orf19.8709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711164.1">
        <property type="nucleotide sequence ID" value="XM_706072.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59N76"/>
    <dbReference type="SMR" id="Q59N76"/>
    <dbReference type="FunCoup" id="Q59N76">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59N76"/>
    <dbReference type="GeneID" id="3647228"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503820CA"/>
    <dbReference type="CGD" id="CAL0000184594">
        <property type="gene designation" value="BUD7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03820C_A"/>
    <dbReference type="eggNOG" id="ENOG502QSKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019711_0_0_1"/>
    <dbReference type="InParanoid" id="Q59N76"/>
    <dbReference type="OMA" id="IEAYQHC"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001902">
        <property type="entry name" value="Exomer complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001904">
        <property type="entry name" value="Exomer complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000184594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="764" mass="86205" checksum="1950748DCE6924D7" modified="2005-04-26" version="1">MLPPTLSSIPEVKEEYPGACLIERTARLPQFIELGPPDLCNIHKYSVNAKRENEIGTFLYFTGVDTSNTASIAAHLQNIANLMTSKSQYWFGEKKHWKVPQLTYCTFNAFSKIDLRVTVHIPGKFEMQIIGQDGKLINDNFNDEQLDKLWSETFLTSIVRAVLESEDGDDVNKIGGLVEVRKINPFNNGITSKELLNNFLSAFELLFFEGVKLGCNVEIPQPTLINNYLVDGFIKVIQLTQSYDRGIEILQKLHEIEPNVISLIAKLQLLKQDEIEAVKTMNHGIQENRRDSDLLVLQAEFCLEKKKPELALELAKQAVKSSPSDFKTWAILVQIYTKLGDFENALLTLNSCPMNSHKEKYFLKRVVPIKSNDDLHLPSPTDVTLDQVSNLQSNEISYEQRNLDPSLVNLPAGNLKSTFAKAYDLLTEIVVKTGWESLLKYRAKVFVMEEEYRKDRQGSATGVNGSQTRKNSTTSTSTSNANGNGNGNGTEAQTPTNNPSTASATTASTTTPSDSDAASTVAIKSPGPSNDTEDTTSSTNVSYDDEFRKKRLCERWLDNLFMLLYEDLRAYTMWQAESLHFQAQQMEYKKTTLEWEILGSIAFRLKHFKEGSIAFANALSGRFSAKSQRELLKYYVMERSKLLSKNSSNQSTTFIHSYTKMMNQLNEKILESIIKLLVWNHRWYSDFSSFLLLTLSDLVAWEGSVKINSSVTALYNETKTTTTSSSSSTNNNSTDHISNHGIIEMMTDLDNDYIKLYNLHNADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PA3</accession>
    <name>Q59PA3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">YFH1</name>
        <name evidence="15" type="ordered locus">CAALFM_C404340CA</name>
        <name evidence="14" type="ordered locus">orf19.8989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711541.1">
        <property type="nucleotide sequence ID" value="XM_706449.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PA3"/>
    <dbReference type="SMR" id="Q59PA3"/>
    <dbReference type="STRING" id="237561.Q59PA3"/>
    <dbReference type="GeneID" id="3646853"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404340CA"/>
    <dbReference type="CGD" id="CAL0000188672">
        <property type="gene designation" value="YFH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04340C_A"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_2_1_1"/>
    <dbReference type="InParanoid" id="Q59PA3"/>
    <dbReference type="OMA" id="YEVEYHS"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010040">
        <property type="term" value="P:response to iron(II) ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000012">
        <property type="entry name" value="Frataxin, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000188672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW29183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="177" mass="19796" checksum="357807AEFADB03A2" modified="2005-04-26" version="1">MFKRFALNSAKCLSKPACTRQLIYPQTRFITKTLPTVASALRPIGSIRAYSLSTEGEAIDDKIDKLTDNEYAKVSNEYLENLSDSLEELNEDFEQVDSELSQGVLTLTLPPNGTYVINKQPPNKQIWLSSPISGPKRYDLIGGKWVTLRDGSSLTSLLEEEISTAIGQEFKFETVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PR4</accession>
    <name>Q59PR4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_CR05640CA</name>
        <name evidence="8" type="ordered locus">orf19.13971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711716.1">
        <property type="nucleotide sequence ID" value="XM_706624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PR4"/>
    <dbReference type="PeptideAtlas" id="Q59PR4"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR05640CA"/>
    <dbReference type="CGD" id="CAL0000201865">
        <property type="gene designation" value="orf19.13971"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05640C_A"/>
    <dbReference type="eggNOG" id="ENOG502SF8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113391_1_0_1"/>
    <dbReference type="InParanoid" id="Q59PR4"/>
    <dbReference type="OMA" id="TFIRFAT"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="64"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000201865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="191" mass="21738" checksum="E7F0BDED72AAA148" modified="2005-04-26" version="1">MTNLRELEEEIETYEGTSGDLQEQNVLQLRQRKLSYTRRPTSQPKVQSKFPYSLVMKVETSEPRDVLQSERTCLTFVRFSTALFFTALGIILNFKLDTSGSPDDNSGNNKKKYFNHTAFNSAISYILLVLALFVLCVTGVNYFVTINRYAKHKIATYSFNNLTTIIGMTSIIVTLMAINITMIVEGYIEQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RA0</accession>
    <accession>A0A1D8PM99</accession>
    <name>RIX1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RIX1</name>
        <name type="ordered locus">CAALFM_C405230CA</name>
        <name type="ORF">CaO19.14152</name>
        <name type="ORF">CaO19.6862</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712250.2">
        <property type="nucleotide sequence ID" value="XM_707157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RA0"/>
    <dbReference type="SMR" id="Q59RA0"/>
    <dbReference type="FunCoup" id="Q59RA0">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59RA0"/>
    <dbReference type="EnsemblFungi" id="C4_05230C_A-T">
        <property type="protein sequence ID" value="C4_05230C_A-T-p1"/>
        <property type="gene ID" value="C4_05230C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646156"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405230CA"/>
    <dbReference type="CGD" id="CAL0000185245">
        <property type="gene designation" value="orf19.14152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05230C_A"/>
    <dbReference type="eggNOG" id="ENOG502R65X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020084_1_0_1"/>
    <dbReference type="InParanoid" id="Q59RA0"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="PRO" id="PR:Q59RA0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000308915" description="Pre-rRNA-processing protein RIX1">
        <location>
            <begin position="1"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="769" mass="87628" checksum="A11066440E3E2C64" modified="2017-03-15" version="2">MSINIVLEEIKGTPSSIIPLLSILHNDKQILSTITKTELNHLISRTLNLVRSSDVYNKWCGINLIRVIVEEYSILASEGNNLMNSLLQVLEAYQQQQHHHHHQTTIDLKILTSCIETINYMGDLIRGKPTLTREILTPKLNSIIGYYFQYLHFAPLLILNSLQTLLKFHPTTFRPFGNKLKTKLINLIDGGGGEEFINYPQDLQLSIYNTLAMLPIIEKIEPETKWYNDVINILGEINGLIQIYQEFLNFKDDQDLSNLIQKLPNRPTTTTTTTKLLTDLSIDFNKPQTILSISNHLNILMGVLKSYLTVETLFTVKLPLGLILTTCELICSINTKFLSFKGDIRDETIKKLIKFSLIENYKTTLGVLIELIELYKGSLIPHLTTIWSFLETLIPFQNQNKRIVNEEIIESESLYVEILQFMKQSLSLLGNVSENTQLLRFVDMALILVEPRINPTTTTTTTNNNNNNNNTKQTNVQQGKKQKKRKNTSSVALSDILSHEHLFMTNIPTITITTVRSFINQIITKIILPPTQHYKIMRYLIIESIHAKYYNLYHNVPIELKKLLINAVLYPGYDKISILPIISTILSDDPLLGVFNNPKFPPLPKYINLVNNIEEEEQKEEQEEDAIIEDEVEEPIKEELTTPLKKRKLDIESNEETDNNNIIPVEDQSKIFTATKVEKLTTTTTSSIENNPVVIEELTSSKEIVVESPVDEPTKVDNIIPTTTTTTTTTTSLTSNTANANDDNDNDDDDESSDFEMPEINLDQDSDDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2025-06-18" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S45</accession>
    <accession>A0A1D8PQT0</accession>
    <accession>Q3MPL3</accession>
    <name>CMR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C701270CA</name>
        <name type="ORF">CaJ7.0141</name>
        <name type="ORF">CaO19.6907</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712479.1">
        <property type="nucleotide sequence ID" value="XM_707386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S45"/>
    <dbReference type="SMR" id="Q59S45"/>
    <dbReference type="FunCoup" id="Q59S45">
        <property type="interactions" value="787"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59S45"/>
    <dbReference type="EnsemblFungi" id="C7_01270C_A-T">
        <property type="protein sequence ID" value="C7_01270C_A-T-p1"/>
        <property type="gene ID" value="C7_01270C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645908"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701270CA"/>
    <dbReference type="CGD" id="CAL0000176214">
        <property type="gene designation" value="orf19.6907"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01270C_A"/>
    <dbReference type="eggNOG" id="KOG4328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017019_1_1_1"/>
    <dbReference type="InParanoid" id="Q59S45"/>
    <dbReference type="OMA" id="DPNTLYW"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000351102" description="DNA damage-binding protein CMR1">
        <location>
            <begin position="1"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="2">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2" evidence="2">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="2">
        <location>
            <begin position="390"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="2">
        <location>
            <begin position="446"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5" evidence="2">
        <location>
            <begin position="526"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6" evidence="2">
        <location>
            <begin position="571"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="602" mass="69057" checksum="F20544265A389053" modified="2005-04-26" version="1">MALSELEKKRQENIRRNQELLKKLDLDSISDSIKKEVDNKSFSSPSSQKRRKTTKKPVIKKEISEPSRRSRRIAGIKSELEDPKQAARIREEEELKQHRKQELERLKRTRLFGDFKLIDLITNKKGDMIFEKNVMDRKLSHIGLDSKVEEKKNEEDKEDEEEAINIDENNRVLQLVQSLGDKFSAGDFYEEIRNSQTNGNSKDKSLDAKRKEFDNLNIYPRFDPLDIKICHNRITSMFFHPSTTNRIVVGGDTTGNVGIWLVDEQNNDTKEEEEDDDDDEPSISILQLHGRNVSKIMTPTFSPEKIYTSSYDGSIRVLDLNKLTSTELLYLNEPGAREDIALGVSDINQCQDSSVIFMTTLDGEFYQHDTRTPFNTRQRHHLATKDLLRLHDKKIGGFAVNPNTNYQIATASLDRTLRIWDLRNVNKSVYSEFENQKSPHMYGNYNSRLSVSCVDWNQENRLVCNGYDDNICLFDYSGGSKLDNELPVITEWKSDFVPSTKSSEESELLPNNLTPFTKIKHNCQTGRWVSILKSHWQTNPADGVQKFIIANMNRGLDIYNQDGQILAHLNEQVGAVPAVCTLHPSQNWAVGGSASGKVYLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SC0</accession>
    <name>Q59SC0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyoxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C208850CA</name>
        <name evidence="6" type="ordered locus">orf19.7855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712608.1">
        <property type="nucleotide sequence ID" value="XM_707515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SC0"/>
    <dbReference type="SMR" id="Q59SC0"/>
    <dbReference type="FunCoup" id="Q59SC0">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SC0"/>
    <dbReference type="GeneID" id="3643890"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208850CA"/>
    <dbReference type="CGD" id="CAL0000175900">
        <property type="gene designation" value="orf19.7855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08850C_A"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="Q59SC0"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="79"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="139"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000175900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40223" checksum="CC39B204856F32EF" modified="2005-04-26" version="1">MSSIFKLSTRTIMTSTTTNSIKPKVLRLGITHYAQHKWDQLSKIAEIIDCESTNREEFIHDLQTKYNDITNISRTFASIKQTGRFDNELAKHMPTTLKAISHCGAGYDQIDVTPFTEIGVQISNVTVPVEGPTADTAIYLVLACMRNFQIGHNILVNGEWPQSKNKKKKKISHALSIGNSPEDKVVGILGMGGIGRAIRDRLKPFGFGKIVYHNRNRLSEELEAGAEYLSMDELLNQSDIIIVSVPLNAHTKHLVNKSLIEKMKDGVILINTARGAVIDEKVLPELIKSGKIGSFGADVFENEPEVSPELYELPQVVSLPHMGTYTVEAVRNMESWVVDNIESYIKTGKVKTIVPEQYNAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q59U73</accession>
    <accession>A0A1D8PHX4</accession>
    <name>MED4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED4</name>
        <name type="ordered locus">CAALFM_C207500CA</name>
        <name type="ORF">CaO19.1878</name>
        <name type="ORF">CaO19.9434</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713135.2">
        <property type="nucleotide sequence ID" value="XM_708042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59U73"/>
    <dbReference type="SMR" id="Q59U73"/>
    <dbReference type="BioGRID" id="1228243">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59U73">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59U73"/>
    <dbReference type="EnsemblFungi" id="C2_07500C_A-T">
        <property type="protein sequence ID" value="C2_07500C_A-T-p1"/>
        <property type="gene ID" value="C2_07500C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645209"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207500CA"/>
    <dbReference type="CGD" id="CAL0000181311">
        <property type="gene designation" value="MED4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07500C_A"/>
    <dbReference type="eggNOG" id="ENOG502RXM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071875_0_0_1"/>
    <dbReference type="InParanoid" id="Q59U73"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="PRO" id="PR:Q59U73"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000302073" description="Mediator of RNA polymerase II transcription subunit 4">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="79"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="323" mass="37008" checksum="C78914A861ECDFF1" modified="2017-03-15" version="2">MLPFKKADSPFKSNPVSRVGSSTRLNQLGNIKSNPTTPNAALYVTSSLNPSKNLPTNAANVKSRLQTQKDLDAFKQLPMVQKVNEYERLLNELSEAVSQFKNDELQEKIGQIITCNDVLKQQIEDLNKHRNYSYEVDKLSDRNKILEENSKFILKELVSYRNELKKLPKLPKSDKMVNRNVDVDDILKYAFKLAKFTKAPATVANMPFQIHPNNYVWPAEDSLRRGMLAQASLQAEEIIRHELGETDKENSNEVKTESKVDHDDDDDDEMEDVRISNENTNDEQRSKPPAASEHDTSKRKEEQNQQPVDLNLDLFDPDDEYSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q59V01</accession>
    <accession>A0A1D8PS63</accession>
    <accession>Q59V37</accession>
    <name>PGA23_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Predicted GPI-anchored protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGA23</name>
        <name type="synonym">PGR23</name>
        <name type="synonym">SLP99</name>
        <name type="ordered locus">CAALFM_CR02280WA</name>
        <name type="ORF">CaO19.11225</name>
        <name type="ORF">CaO19.3740</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Eukaryot. Cell" volume="2" first="718" last="728">
            <title>Diverged binding specificity of Rim101p, the Candida albicans ortholog of PacC.</title>
            <authorList>
                <person name="Ramon A.M."/>
                <person name="Fonzi W.A."/>
            </authorList>
            <dbReference type="PubMed" id="12912891"/>
            <dbReference type="DOI" id="10.1128/EC.2.4.718-728.2003"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Mol. Biol. Cell" volume="15" first="4490" last="4499">
            <title>Transcription profiling of cyclic AMP signaling in Candida albicans.</title>
            <authorList>
                <person name="Harcus D."/>
                <person name="Nantel A."/>
                <person name="Marcil A."/>
                <person name="Rigby T."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="15269278"/>
            <dbReference type="DOI" id="10.1091/mbc.E04-02-0144"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2913" last="2925">
            <title>Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.</title>
            <authorList>
                <person name="Garcia-Sanchez S."/>
                <person name="Mavor A.L."/>
                <person name="Russell C.L."/>
                <person name="Argimon S."/>
                <person name="Dennison P."/>
                <person name="Enjalbert B."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15814841"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-01-0071"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2006" name="FEMS Yeast Res." volume="6" first="1085" last="1093">
            <title>An in vitro assay to study the transcriptional response during adherence of Candida albicans to different human epithelia.</title>
            <authorList>
                <person name="Sohn K."/>
                <person name="Senyurek I."/>
                <person name="Fertey J."/>
                <person name="Konigsdorfer A."/>
                <person name="Joffroy C."/>
                <person name="Hauser N."/>
                <person name="Zelt G."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="17042758"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2006.00130.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="Antimicrob. Agents Chemother." volume="57" first="873" last="886">
            <title>Milbemycins: more than efflux inhibitors for fungal pathogens.</title>
            <authorList>
                <person name="Silva L.V."/>
                <person name="Sanguinetti M."/>
                <person name="Vandeputte P."/>
                <person name="Torelli R."/>
                <person name="Rochat B."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="23208712"/>
            <dbReference type="DOI" id="10.1128/AAC.02040-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable cell surface protein involved in the process of adhesion and early events of invasion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <topology evidence="8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5 6 7">Up-regulated when cells are growing in an adherent manner and upon milbemycins A3 oxim derivative (A3Ox) treatment. Expression is also regulated by CYR1, RIM101 and SSN6.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713428.1">
        <property type="nucleotide sequence ID" value="XM_708335.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59V01"/>
    <dbReference type="STRING" id="237561.Q59V01"/>
    <dbReference type="GlyCosmos" id="Q59V01">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CR_02280W_A-T">
        <property type="protein sequence ID" value="CR_02280W_A-T-p1"/>
        <property type="gene ID" value="CR_02280W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644941"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02280WA"/>
    <dbReference type="CGD" id="CAL0000196898">
        <property type="gene designation" value="PGA23"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02280W_A"/>
    <dbReference type="HOGENOM" id="CLU_1042056_0_0_1"/>
    <dbReference type="InParanoid" id="Q59V01"/>
    <dbReference type="OMA" id="PMGPRGC"/>
    <dbReference type="OrthoDB" id="10670740at2759"/>
    <dbReference type="PRO" id="PR:Q59V01"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424927" description="Predicted GPI-anchored protein 23">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424928" description="Removed in mature form" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="1">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12912891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15269278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15814841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17042758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="23208712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="282" mass="24390" checksum="75AE9831098891B8" modified="2005-04-26" version="1" precursor="true">MRVSTLVLSTSIIPIATALNISPFHNIEKKDILADAASAAGGAAAAVTSGAVGAANTVASGAAGAADTATSGAAGIANTVASGAAGAADTATSGAAGAAKTATSGAAGAADTATSGAVGAAKTATSGAAGAAKTATSGAAGAASGAETAAGAAASGAETAAAGQETSGAGSLVGGSGSSNSTSPSGGSGSSNGTSSGSGSGSGAGVGSGSGSGSGSRGSITGNSVATGASSGPAGLGISSSISQSTTRQLQTSGSSNSSSSAGMGNVVVGMNAVALAALVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WV9</accession>
    <name>Q59WV9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mic17p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C600920WA</name>
        <name evidence="2" type="ordered locus">orf19.7739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714302.1">
        <property type="nucleotide sequence ID" value="XM_709209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WV9"/>
    <dbReference type="SMR" id="Q59WV9"/>
    <dbReference type="FunCoup" id="Q59WV9">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WV9"/>
    <dbReference type="GeneID" id="3644031"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600920WA"/>
    <dbReference type="CGD" id="CAL0000196544">
        <property type="gene designation" value="orf19.7739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00920W_A"/>
    <dbReference type="HOGENOM" id="CLU_093520_0_1_1"/>
    <dbReference type="InParanoid" id="Q59WV9"/>
    <dbReference type="OMA" id="CDADARN"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044114">
        <property type="term" value="P:development of symbiont in host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000196544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15988" checksum="9D4B5C424B4838C0" modified="2005-04-26" version="1">MPRQRRSAPAPRQQTRSAHTAAAPAHHAPPQSYPSAHPAQPVQTQSSQPGLFGQMASTAAGVAVGSTIGHTLGAGITGLFGGSSSSAPVEAAPQQQQVAAYQQQQTQEQAKHCDADARNFTRCLEDNGGNMQICDYYLQQLKACQEASRQY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q59X26</accession>
    <accession>A0A1D8PHK5</accession>
    <name>CSM3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Chromosome segregation in meiosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CSM3</name>
        <name type="ordered locus">CAALFM_C206130WA</name>
        <name type="ORF">CaO19.11586</name>
        <name type="ORF">CaO19.4105</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714276.1">
        <property type="nucleotide sequence ID" value="XM_709183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59X26"/>
    <dbReference type="SMR" id="Q59X26"/>
    <dbReference type="STRING" id="237561.Q59X26"/>
    <dbReference type="EnsemblFungi" id="C2_06130W_A-T">
        <property type="protein sequence ID" value="C2_06130W_A-T-p1"/>
        <property type="gene ID" value="C2_06130W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644083"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206130WA"/>
    <dbReference type="CGD" id="CAL0000183710">
        <property type="gene designation" value="CSM3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06130W_A"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068092_0_0_1"/>
    <dbReference type="InParanoid" id="Q59X26"/>
    <dbReference type="OMA" id="ADMDDMW"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="PRO" id="PR:Q59X26"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0236">DNA replication inhibitor</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000301714" description="Chromosome segregation in meiosis protein 3">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="316" mass="35689" checksum="737A839DDD257765" modified="2005-04-26" version="1">MSYVMDETEEGINIDNTQHDLELDRDSSTQQPAQTHEDDGDLLGLDKPIKLKTRAKIAKVDNQRIFNHNGIPLLVKTHSKLLRTLKKNDKNFYSEPRSSISKSQKFEHEYENLSSVLQFYQLWCHGLFPKATFKDCIHLIRALGARSPQLRLYRRELIAAELHKLKVAKGIIADENQDAPSIPEEENTTDPSNEEWNSMHMSALVPGSSNKNGLFVDSNSNEDFETTNEVNAAASLADKDALSTDDKAEQTNAITSDTHNNDVDSDDPFSDDDDINIDAHTENLHPASGTQHQDRPKETTEENEDLELELMREYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YC0</accession>
    <name>Q59YC0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C209480WA</name>
        <name evidence="2" type="ordered locus">orf19.8984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714577.1">
        <property type="nucleotide sequence ID" value="XM_709484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YC0"/>
    <dbReference type="FunCoup" id="Q59YC0">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YC0"/>
    <dbReference type="GeneID" id="3643819"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209480WA"/>
    <dbReference type="CGD" id="CAL0000189572">
        <property type="gene designation" value="orf19.8984"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09480W_A"/>
    <dbReference type="eggNOG" id="KOG3186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1142929_0_0_1"/>
    <dbReference type="InParanoid" id="Q59YC0"/>
    <dbReference type="OMA" id="FFKITVD"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000189572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="30766" checksum="C9003A8F3909D011" modified="2005-04-26" version="1">MKSHSLPLTVENFLLTFKEYFTVWLNQILYYNHVYEQLTFDQFKSFDLIIYKNRNPQLQGYIEQLIVNVINQLIINQKQSQSKQRQKQKKQQETFNGLYGINCLVYHSTNNTVVRQYTINFHEFIINLNETINELKLHDKDEDNSAIINIESLNWDEIYTQYSTILFHHIQQLKIHEKSLIEERQQDLEVDDLFFKITVDVDQSLYINNYGNWVRLKRDGNRDNDSRDNETQCIFEPIGDVNLELLNFNCYNKVFT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YU1</accession>
    <accession>A0A1D8PKE4</accession>
    <name>AIM23_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM23</name>
        <name type="ordered locus">CAALFM_C305440CA</name>
        <name type="ORF">CaO19.6982</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714688.2">
        <property type="nucleotide sequence ID" value="XM_709595.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YU1"/>
    <dbReference type="FunCoup" id="Q59YU1">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_05440C_A-T">
        <property type="protein sequence ID" value="C3_05440C_A-T-p1"/>
        <property type="gene ID" value="C3_05440C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643668"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305440CA"/>
    <dbReference type="CGD" id="CAL0000184331">
        <property type="gene designation" value="orf19.6982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05440C_A"/>
    <dbReference type="eggNOG" id="ENOG502RY27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054408_0_0_1"/>
    <dbReference type="InParanoid" id="Q59YU1"/>
    <dbReference type="OrthoDB" id="3996489at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029427">
        <property type="entry name" value="AIM23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14877">
        <property type="entry name" value="mIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399530" description="Altered inheritance of mitochondria protein 23, mitochondrial">
        <location>
            <begin position="19"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="429" mass="49967" checksum="78B7AB0365CF9578" modified="2017-03-15" version="2" precursor="true">MSLRIILKREFSQCIRVLESGSKSPTIANRFQAQYGNKNNNSKRNTANNGTGNGNRFHNKYNNESRRPYPKTKYQQQQQQQQQQRKPQQHQQYIIDPRKIKFDNGTESARNAIEEIINRVYQLQRNYQIQLITDSGLKKCHLSEILQKLDLSINGLQLIDKSTTTTATTTTPTTNTSDEDLPLIKIITVRDMINQYSTYLNNLKQLELIKLGSSKTLKTLDIKLKLEQKKSTTKEILMKWSINNNDFKLQKTNEIKKLINNNGGNGKSFLINMVYNKRNTNKPIDTIFKRRSNTEEDEQELIEIELQRRQLLIENLQSLLTELNCKWTIEGDINTKMTFNVTPKGQPTTIEPSTTTNIVDEEVEDYNNNNNDDDGDCDEKKMNRTERKKRKSEQQKQKQKQKQQSKTNTNSNTAKEEDLDALYSFKIED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZZ6</accession>
    <accession>A0A1D8PSI4</accession>
    <name>EXO5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Exonuclease V, mitochondrial</fullName>
            <shortName>Exo V</shortName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Defects in morphology protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DEM1</name>
        <name type="synonym">EXO5</name>
        <name type="ordered locus">CAALFM_CR03490WA</name>
        <name type="ORF">CaO19.11870</name>
        <name type="ORF">CaO19.4392</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW31087" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31087.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715168.2">
        <property type="nucleotide sequence ID" value="XM_710075.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZZ6"/>
    <dbReference type="FunCoup" id="Q59ZZ6">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZZ6"/>
    <dbReference type="GeneID" id="3643200"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03490WA"/>
    <dbReference type="eggNOG" id="ENOG502QR0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019985_0_0_1"/>
    <dbReference type="InParanoid" id="Q59ZZ6"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="PRO" id="PR:Q59ZZ6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
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    </dbReference>
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        <property type="term" value="P:interstrand cross-link repair"/>
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    </dbReference>
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        <property type="entry name" value="EXOV"/>
    </dbReference>
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        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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        <location>
            <begin position="22"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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        <location>
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        </location>
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        <location>
            <position position="589"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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        <location>
            <position position="595"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="628" mass="72427" checksum="49AA7D8685397AE1" modified="2017-03-15" version="2" precursor="true">MSRFWHFKKFYFTSCYSMQRMRGKIFKNEPLVPMNVTSEHEQVQSISKEESRSLSSNDLNLSADSELQLESEPEIESEQLKNHEDVYEIIRSMVLAADTTLPRLSNNSLTGIYNHWKLNPNDDLPLYNPTKYTPYEFHSQYNQDRSYIITPRLSVTKLLVSSWCELRSFYQVYSGSVRLPSTKAMTQGTKLHSKLEAEVHPEIDTTEIEQFLISNAMSLRELQTTVPAEEETVVIDLGEVEQLAVDWAEMLIERLFSLIMGAEAREILLHGYLNLKNRSFVTNKDEIRESSSVLVSGIVDYIKLQNVTNPSDGTLFDDIHGFVDSAFDQVDNVPLVDLSQFLPEAKQILQNYDFRLTFTDVKTRSARQIPRQESVLEAAKFQTFYYRHFFHLLSRDSRFTYFSLIENAERRGHDVDKPLSILTTISLLRKHYHIFFKDFVKLANGEPIGFSPFDDSAKSIPYDFVSMFQSSDEFSLANPNHNHFLEQISAIDGIEYDSILSPLLKVWKTPPTLRYLAARASQLFNVFNENIGDITSVEYRYNKTSELLSEKVYDYNFSEFQAEVESASKFWNGEREVIPTEDLSRCSYCEFQSKCMVAGGKTTEAVEKKTIGPKIRQFLNECESSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0I8</accession>
    <name>Q5A0I8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sgt2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">SGT2</name>
        <name evidence="8" type="ordered locus">CAALFM_C202830CA</name>
        <name evidence="7" type="ordered locus">orf19.13245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715364.1">
        <property type="nucleotide sequence ID" value="XM_710271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0I8"/>
    <dbReference type="SMR" id="Q5A0I8"/>
    <dbReference type="FunCoup" id="Q5A0I8">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0I8"/>
    <dbReference type="GeneID" id="3642978"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202830CA"/>
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        <property type="gene designation" value="SGT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02830C_A"/>
    <dbReference type="eggNOG" id="KOG0553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q5A0I8"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Hsc70 cochaperone (SGT), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000011">
        <property type="entry name" value="TPR Domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000193564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="344" mass="36462" checksum="EF0540FD8DE09AAB" modified="2005-04-26" version="1">MSSTITNKDIALSIIDFLKQSVAKKEVAEDYAESMDVAIDCIADAFEVNKEDDSKTLKDVFHGKSLSELLKSSVSFSSTSEKSESVPAAKEVDADTKAKADELKVQGNRAMALKDYPEAIAKYTEAIGLDPSNVVYLSNRAAAHSSSQKHDKAVEDAEKAIKLDPNFSKAYSRLGLAKYALGDAKGAMEAYKKGLEVEGETKSDAMRKGYETAKKRVEEELENSISTTDKSGESSGSSESATGAGAGAGAGAGGLPDMSSFLGGGGGMPNLAEMMNNPQIMQAAQEMMSNPAAMQNLFSNPAVKQMAQQMGLGGENGPDLSNIMNNPMFNQFMGGRENQGDKPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1A9</accession>
    <accession>A0A1D8PMI7</accession>
    <name>PGA43_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Predicted GPI-anchored protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGA43</name>
        <name type="ordered locus">CAALFM_C406260WA</name>
        <name type="ORF">CaO19.10428</name>
        <name type="ORF">CaO19.2910</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715565.1">
        <property type="nucleotide sequence ID" value="XM_710472.1"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.Q5A1A9"/>
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        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_06260W_A-T">
        <property type="protein sequence ID" value="C4_06260W_A-T-p1"/>
        <property type="gene ID" value="C4_06260W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642804"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406260WA"/>
    <dbReference type="CGD" id="CAL0000197415">
        <property type="gene designation" value="PGA43"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06260W_A"/>
    <dbReference type="HOGENOM" id="CLU_101463_0_0_1"/>
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    <dbReference type="OMA" id="CCNELLH"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424945" description="Predicted GPI-anchored protein 43">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424946" description="Removed in mature form" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="236" mass="26292" checksum="523D609E5F143354" modified="2005-04-26" version="1" precursor="true">MHQRNHHSILLTLLLYLQSIVALARIIDPEFGTYSNPNPRKYPQCQANDLVKLSSCCNELLHKLDQCKSDDLACECCALQSIDRDCYHLCPGNPSTNFLTVLLQDCAQLSEINACALPFKKTDDLLVDKKKGTPNSKSAVQALEADEKYDASLKSKVHNKVDEIKSHVKQDQFLKKKIKLLIDKDETFAIQNHSNNSNNTISAKSESGSVCLTSSYLNSPIIILCAILTGTLFAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1L3</accession>
    <name>Q5A1L3_CANAL</name>
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        <recommendedName>
            <fullName evidence="1">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C500850CA</name>
        <name evidence="2" type="ordered locus">orf19.8220</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714215.1">
        <property type="nucleotide sequence ID" value="XM_709122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1L3"/>
    <dbReference type="SMR" id="Q5A1L3"/>
    <dbReference type="FunCoup" id="Q5A1L3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="3642637"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500850CA"/>
    <dbReference type="CGD" id="CAL0000186476">
        <property type="gene designation" value="orf19.8220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00850C_A"/>
    <dbReference type="eggNOG" id="ENOG502S4BW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160816_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A1L3"/>
    <dbReference type="OMA" id="LAFHQCM"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mix14"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UCP013232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000186476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="105" mass="12076" checksum="2B750C420E6EA9BC" modified="2005-04-26" version="1">MDQTKPGFLDQFLLEDISRHCPHQFLSFHQCMTLPQPDPNQCFQQQVDLTKCIKTSVPSFAKIQNECFGKMQAYEACLKMNKSNTKSCSHELQNLRNCAFGTIDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1V3</accession>
    <accession>A0A1D8PN47</accession>
    <accession>Q5A1P5</accession>
    <name>POA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber>3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">POA1</name>
        <name type="ordered locus">CAALFM_C501200WA</name>
        <name type="ORF">CaO19.1950</name>
        <name type="ORF">CaO19.9506</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the POA1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715713.2">
        <property type="nucleotide sequence ID" value="XM_710620.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1V3"/>
    <dbReference type="SMR" id="Q5A1V3"/>
    <dbReference type="FunCoup" id="Q5A1V3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C5_01200W_A-T">
        <property type="protein sequence ID" value="C5_01200W_A-T-p1"/>
        <property type="gene ID" value="C5_01200W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642657"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501200WA"/>
    <dbReference type="CGD" id="CAL0000194527">
        <property type="gene designation" value="orf19.9506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01200W_A"/>
    <dbReference type="eggNOG" id="ENOG502S60W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054419_1_2_1"/>
    <dbReference type="InParanoid" id="Q5A1V3"/>
    <dbReference type="OrthoDB" id="2155246at2759"/>
    <dbReference type="PRO" id="PR:Q5A1V3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047407">
        <property type="term" value="F:ADP-ribosyl-[dinitrogen reductase] hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000324904" description="ADP-ribose 1''-phosphate phosphatase">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="156" mass="17453" checksum="F4FB0140D21B0BDC" modified="2017-03-15" version="2">MIQYIKGDLFTHAIPAGKKVILAHACNTHGSWGGGIAAVFRKKFPKSNNEYSQYCHKNSNLLGTSFIIESDQPNILIACLFTSDFNQTPEQIVHFTKQSIADLARKVSDYKEVEKCDGKVAINMPKINAGIFGVPWEDTESALQEFDNLHFNVYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A340</accession>
    <name>Q5A340_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
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    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_CR08550WA</name>
        <name evidence="8" type="ordered locus">orf19.13781</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="316"/>
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        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3M0</accession>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716319.1">
        <property type="nucleotide sequence ID" value="XM_711226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3M0"/>
    <dbReference type="SMR" id="Q5A3M0"/>
    <dbReference type="STRING" id="237561.Q5A3M0"/>
    <dbReference type="GeneID" id="3642050"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112140WA"/>
    <dbReference type="CGD" id="CAL0000181678">
        <property type="gene designation" value="orf19.12715"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12140W_A"/>
    <dbReference type="eggNOG" id="ENOG502S6U8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000181678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="162" mass="17930" checksum="43AD5500F1AD43A9" modified="2005-04-26" version="1">MSMKSKIKSFFGKNRQYAVAGASNNPSKFGYKILNWYILHDLPVIPINPKEQEILGKEVVSNVSAIINAIEKHQDISNYKTSGVDGLSISFLTPPAVTVATLEEIGKIDGFDKVIKGLWFQPGSYDNEVLELAEKLGEFDKVVHEDECILVRGEEGMISANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A441</accession>
    <name>Q5A441_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C405810WA</name>
        <name evidence="4" type="ordered locus">orf19.8853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_711482.2"/>
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        <property type="entry name" value="J_dom_sf"/>
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        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
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        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
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        <property type="entry name" value="JDOMAIN"/>
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    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000192614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="461" mass="52667" checksum="FEDA649A9526F1FC" modified="2005-04-26" version="1">MVKDTTYYDILQVEVTATDVELKKAYRKQAIKLHPDKNANDPKAAEKFQELGEAYGILSNPESRKIYDEFGVEGMKENPTMQQAADIDPAEFFNMIFGGDSFKQWIGELSMLNDMSRMGEIITEDEVELDNVEEESKSGKQHGATDSLNESVQTLTISDNNNNNNTKVSSSNNKPTSNLTSEEIKKLKKQKINEQQREQMLKYQEEAKQAKLKRIDDLTSALLKRIENYQLSKNNKEALDSFTRKLQTEFEDMKIESFGIQLLHLIGKIYIDKANATIHASKTFGVSKIFTSVKSKTETVKNGYSILKTAVDAQLSIEQMVKEQEQFLLAQEEGHQPTQEELVKQAEMERIITGKFLATAWATTKFEVTDILRKVCHNVLRDKTISKKERVARAEALLYIGKEMSKVERSPEEEEEARIFEEMMAEAQAKKSSKKQKSMNNKELEEYMKKMAAENAEAEEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A649</accession>
    <accession>A0A1D8PM27</accession>
    <name>ATG1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG1</name>
        <name type="ordered locus">CAALFM_C404450CA</name>
        <name type="ORF">CaO19.11322</name>
        <name type="ORF">CaO19.3841</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717245.2">
        <property type="nucleotide sequence ID" value="XM_712152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A649"/>
    <dbReference type="SMR" id="Q5A649"/>
    <dbReference type="FunCoup" id="Q5A649">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A649"/>
    <dbReference type="EnsemblFungi" id="C4_04450C_A-T">
        <property type="protein sequence ID" value="C4_04450C_A-T-p1"/>
        <property type="gene ID" value="C4_04450C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641175"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404450CA"/>
    <dbReference type="CGD" id="CAL0000188572">
        <property type="gene designation" value="ATG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04450C_A"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006447_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A649"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PRO" id="PR:Q5A649"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000085641" description="Serine/threonine-protein kinase ATG1">
        <location>
            <begin position="1"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="64"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="834" mass="92910" checksum="4E190372160511DE" modified="2017-04-12" version="2">MIPQSNPTAQRRSGDAQNTNNVAPNSVATTTDTALTASTQSGSSSNNANKKLEYIGVYKIGPEIGKGSFATVYKCIDTTNNKAVAIKSVYRSKLKSKKLLENLEIEIQILKSMKHPHIVGLLDYKQTTSYFHLVMDYCSMGDLSYFIRRRNNLVKSHPVISSLLHCYPSPEGSHGLNEVLVLHFLRQLSSALQFLRDKSLVHRDIKPQNLLLCPPVHSKQEFIDGEFVGMWELPILKIADFGFARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFKAGNHIELLKNIEKANDKIKFPSAAQVPEPLKQLIRSLLKYNPTERISFNEFFNDSLITCDLDDNDQPLETSQMDENLFISEYISPIAPAERSQFFKEQKKNDSVVRSPSPTTATTATPRQDNVVQQMTKITSPVPDDFALSIARNSSEFNLKKDDMNLEKDYVVVEKRAVEVNALADELAHAGAGADAIPNSRKNSDVDQTNRLASSQQQTETASYRRSSSSGSQKRPSFSERRISLSLSPTNALTKAIGLASNRLFGLTTNSSHSNVSAIAEDDDSSTSNNDASSFSTVIPSTNNHVLLQKLNLATIGEPGTEFDLGSVSNLDEQILDKLELIANIANAVNLYADVKFSQIIPSPPSSDGIEDDTEMLPPKIIHMISQEGIGLYIKTLSLLGRAMDIAGQWWFEKYDAVHGERPSFETTVRINQIVQWIREKYNISLERLEFLKSKSDFTAEETIEDNEPNGTTRVQQAIFAAALGIARETALKELLRNSTDIECSYVTSIYMLLAILEDLEESDRQEVKKIIEKINSRLKNFMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A668</accession>
    <name>Q5A668_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 24" type="primary">SCS7</name>
        <name evidence="24" type="ordered locus">CAALFM_C404590WA</name>
        <name evidence="23" type="ordered locus">orf19.11303</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717227.1">
        <property type="nucleotide sequence ID" value="XM_712134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A668"/>
    <dbReference type="SMR" id="Q5A668"/>
    <dbReference type="FunCoup" id="Q5A668">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A668"/>
    <dbReference type="GeneID" id="3641157"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404590WA"/>
    <dbReference type="CGD" id="CAL0000201815">
        <property type="gene designation" value="SCS7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04590W_A"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A668"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000038">
        <property type="term" value="P:very long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_712733.1"/>
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        <property type="gene designation" value="orf19.12910"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C3_00170C_A"/>
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    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="entry name" value="VTC_Complex_Subunit"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000201471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="115" mass="12936" checksum="3A8D7D01BCBE5234" modified="2005-04-26" version="1">MSSTNKRIALPARVEPKVFFANERTFLSWLNFTVILGSLGVGLLNFGDYVGRISAGLFTFIAMLTMVYALVTYHWRAKAIRLRGSGPYDDRFGPTMLCIFLLVAVVVNFILRIRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AB87</accession>
    <name>RL16A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L16-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL16A</name>
        <name type="synonym">RPL16</name>
        <name type="ordered locus">orf19.6085</name>
        <name type="ORF">CAALFM_C100180WA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_713954.1"/>
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        <property type="resolution" value="2.67 A"/>
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    <dbReference type="GO" id="GO:0030447">
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    <reference key="29">
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        <scope>FUNCTION</scope>
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            <title>Inhibition of Candida albicans virulence factors by novel levofloxacin derivatives.</title>
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        <text evidence="4 5 8 12 13 19 20 25 31 32 33 34 35 36 39">Plasma membrane multidrug efflux pump that confers resistance to numerous chemicals including azoles such as fluconazole, voriconazole, and benztriazoles, as well as to benomyl, cycloheximide, methotrexate, 4-nitroquinoline-N-oxide, sulfometuron methyl, cerulenin, and brefeldin A.</text>
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            <location evidence="25">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="induction">
        <text evidence="6 7 9 10 11 13 14 15 16 17 18 21 22 23 24 26 27 28 29 30 37">Constitutive, high-level transcription is commonly observed in laboratory and clinical strains of Candida albicans that are resistant to the antifungal drug fluconazole. Multiple cis-acting sequences within the promoter mediate its activation. One, a benomyl response element (BRE), is situated at position -296 to -260. It is required for benomyl-dependent MDR1 up-regulation and is also necessary for constitutive high expression of MDR1. A second element, termed H(2)O(2) response element (HRE), is situated at position -561 to -520. The HRE is required for H(2)O(2)-dependent MDR1 up-regulation, but dispensable for constitutive high expression. Two potential binding sites (TTAG/CTAA) for the transcription factor CAP1 lie within the HRE. Expression is induced by fluconazole, rifampicin, methotrexate, diethylmaleate, diamide, 4-nitroquinoline-N-oxide, benomyl, o-phenanthroline (OP), hydrogen peroxide, methyl methanesulfonate, and sulfometuron methyl. Expression is down-regulated by tetrandrine and levofloxacin derivatives. Transcription is positively regulated by ADA2, CAP1, MRR1, UPC2, and TAC1; and negatively regulated by REP1. Transcription is also regulated by the general transcription factor MCM1. MCM1 is dispensable for up-regulation by H(2)O(2) but is required for full induction by benomyl.</text>
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        <text evidence="25">The central cytoplasmic loop (residues 295 to 350) is critical for the function, but unlike other homologous proteins, has no apparent role in imparting substrate specificity or in the recruitment of the transporter protein.</text>
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        <text evidence="4 31 33">Leads to enhanced susceptibility against fluconazole, methotrexate, 4-nitroquinoline-N-oxide, and cycloheximide.</text>
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        <text evidence="40">The overexpression of MDR1 is a frequent cause of resistance to the widely used antimycotic agent fluconazole and other toxic compounds in the pathogenic yeast Candida albicans.</text>
    </comment>
    <comment type="similarity">
        <text evidence="40">Belongs to the major facilitator superfamily. CAR1 family.</text>
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        <original>E</original>
        <variation>A</variation>
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Leads to general drug-sensitivity." evidence="25">
        <original>K</original>
        <variation>A</variation>
        <location>
            <position position="329"/>
        </location>
    </feature>
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    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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            <dbReference type="PubMed" id="21402859"/>
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            <dbReference type="PubMed" id="8031026"/>
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            <dbReference type="PubMed" id="8891134"/>
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    <evidence type="ECO:0000269" key="34">
        <source>
            <dbReference type="PubMed" id="9210670"/>
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    <evidence type="ECO:0000269" key="35">
        <source>
            <dbReference type="PubMed" id="9756759"/>
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    <evidence type="ECO:0000269" key="36">
        <source>
            <dbReference type="PubMed" id="9797228"/>
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    </evidence>
    <evidence type="ECO:0000269" key="37">
        <source>
            <dbReference type="PubMed" id="9922230"/>
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    </evidence>
    <evidence type="ECO:0000303" key="38">
        <source>
            <dbReference type="PubMed" id="7726508"/>
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    </evidence>
    <evidence type="ECO:0000303" key="39">
        <source>
            <dbReference type="PubMed" id="9046086"/>
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    </evidence>
    <evidence type="ECO:0000305" key="40"/>
    <sequence length="564" mass="62904" checksum="BC0DF5BEA61D5C4F" modified="2017-04-12" version="2">MHYRFLRDSFVGRVTYHLSKHKYFAHPEEAKDYIVPEKYLADYKPTLADDTSINFEKEEIDNQGEPNSSQSSSSNNTIVDNNNNNDNDVDGDKIVVTWDGDDDPENPQNWPTLQKAFFIFQISFLTTSVYMGSAVYTPGIEELMHDFGIGRVVATLPLTLFVIGYGVGPLVFSPMSENAIFGRTSIYIITLFLFVILQIPTALVNNIAGLCILRFLGGFFASPCLATGGASVADVVKFWNLPVGLAAWSLGAVCGPSFGPFFGSILTVKASWRWTFWFMCIISGFSFVMLCFTLPETFGKTLLYRKAKRLRAITGNDRITSEGEVENSKMTSHELIIDTLWRPLEITVMEPVVLLINIYIAMVYSILYLFFEVFPIYFVGVKHFTLVELGTTYMSIVIGIVIAAFIYIPVIRQKFTKPILRQEQVFPEVFIPIAIVGGILLTSGLFIFGWSANRTTHWVGPLFGAATTASGAFLIFQTLFNFMGASFKPHYIASVFASNDLFRSVIASVFPLFGAPLFDNLATPEYPVAWGSSVLGFITLVMIAIPVLFYLNGPKLRARSKYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ACX4</accession>
    <name>Q5ACX4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">RFA1</name>
        <name evidence="16" type="ordered locus">CAALFM_C200380CA</name>
        <name evidence="15" type="ordered locus">orf19.9640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_714446.1"/>
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        <property type="interactions" value="1221"/>
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    <dbReference type="GeneID" id="3638823"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C2_00380C_A"/>
    <dbReference type="eggNOG" id="KOG0851">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_012393_2_0_1"/>
    <dbReference type="InParanoid" id="Q5ACX4"/>
    <dbReference type="OMA" id="DQCDAFY"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:condensed nuclear chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="11">
        <location>
            <begin position="183"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="302"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="458"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000199773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="624" mass="69784" checksum="556ABABC8BEE53F3" modified="2005-04-26" version="1">MSSLQLSKGALKQVFSKEGHDSVQIPMILQITNIKAFDVSPSDSKKFRILVNDGVYSTHGLIDESCSEYIKNNNCQRYAIVQVNAFSIFATSKHFFVIKNFEVLAPTSEKSPNNIIPIDTYFLEHPEENYLTVMKKSESRDRESPVPGVTPPLAQSTNSFKSEVGGGVAAQSKPAGTHRKVSPIETISPYQNNWTIKARVSYKGDLRTWSNSKGEGKVFGFNLLDESDEIKASAFNETAERAHKLLEEGKVYYISKARVAAARKKFNTLSHPYELTFDKDTEITECFDESDVPKLNFNFVKLDQVQNLEANAIIDVLGALKTVFPPFQITAKSTGKVFDRRNILVVDETGFGIELGLWNNTATDFNIEEGTVVAVKGCKVSDYDGRTLSLTQAGSIIPNPGTPESFKLKGWYDNIGIHESFKSLKIDNAGSGGDKISQRISINQALEEHSGSTEKPDYFSIKASVTFCKPENFAYPACPNLVQNADATRPAQVCNKKLVFQDNDGTWRCERCAKTYEEPTWRYVLSCSVTDSTGHMWVTLFNDQAEKLLGIDATELVKKKEQKSEVANQIMNNTLFKEFSLRVKAKQETYNDELKTRYSAAGINELDYASESQFLIKKLDQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEB3</accession>
    <name>Q5AEB3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C303570CA</name>
        <name evidence="9" type="ordered locus">orf19.7988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720050.1">
        <property type="nucleotide sequence ID" value="XM_714957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEB3"/>
    <dbReference type="SMR" id="Q5AEB3"/>
    <dbReference type="GeneID" id="3638300"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303570CA"/>
    <dbReference type="CGD" id="CAL0000175763">
        <property type="gene designation" value="orf19.7988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03570C_A"/>
    <dbReference type="eggNOG" id="ENOG502R0XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AEB3"/>
    <dbReference type="OMA" id="NNWHTDV"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="114"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000175763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="423" mass="48328" checksum="2E122A96B7696A2F" modified="2005-04-26" version="1">MAPTAVTQEPEDVQETIKRLAGLKVIGHSKNSKGIITGYDPEWADKLPETTKQRYAKYGVDISKGYPYVPVNEKVPKFVDEVFAIRNEEYPYIERGKNADPEKKSLFDAAEDVIHLTPYIGTEIVGLQLSELTEQQRDELALLIAERVVVFFKDQDLSPQKQLELGHYWGQVEVHPQATRIGEEYDGISVIWQEQQRDRWGLNLTFKQSKKGNSQWHSDLVHEKQTAGITHLHLDAIPGIGGETLWSSTYGAYDKLSPALQKFLDGKTAIYRSAHQYLDRNDPLKGPKYVEREHPIVRTHPVTGWKYLFVNRSMTVRIVGLLPEESDLILNYLYSVIETNRDIQVRWSWQKELGSVKNNKKDEPKQYRGVSALWDNRISNHSVVHSEESIVGRHGTRVTSLADTGYYDPNSKSQRESLGLSLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-12-09" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEK8</accession>
    <accession>A0A1D8PJJ1</accession>
    <name>SLD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="4">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SLD1</name>
        <name type="ordered locus">CAALFM_C302680CA</name>
        <name type="ORF">CaO19.260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2008" name="Microbiology" volume="154" first="3795" last="3803">
            <title>Disruption of the sphingolipid delta(8)-desaturase gene causes a delay in morphological changes in Candida albicans.</title>
            <authorList>
                <person name="Oura T."/>
                <person name="Kajiwara S."/>
            </authorList>
            <dbReference type="PubMed" id="19047747"/>
            <dbReference type="DOI" id="10.1099/mic.0.2008/018788-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46280"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:85953"/>
            <dbReference type="EC" id="1.14.19.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Has a decreased hyphal growth rate and is highly sensitive to SDS and fluconazole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="4"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719958.2">
        <property type="nucleotide sequence ID" value="XM_714865.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEK8"/>
    <dbReference type="SMR" id="Q5AEK8"/>
    <dbReference type="STRING" id="237561.Q5AEK8"/>
    <dbReference type="EnsemblFungi" id="C3_02680C_A-T">
        <property type="protein sequence ID" value="C3_02680C_A-T-p1"/>
        <property type="gene ID" value="C3_02680C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638406"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302680CA"/>
    <dbReference type="CGD" id="CAL0000198953">
        <property type="gene designation" value="SLD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02680C_A"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AEK8"/>
    <dbReference type="OMA" id="LYNCNYF"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </feature>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="CGD" id="CAL0000185286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="313" mass="35785" checksum="C45DF71CFD2E898D" modified="2005-04-26" version="1">MSSSQPQMSFAQTYILASKVRSKLTREAQSPKSSLRNLVVQANMLDNIMDYISDETKRRTSEKLTSKTNTQKSSSGYLSPESSMVQFAPTPVRQAYKTSITEYEIDSDSSDDDEEEEEEDHEDDNEDDYFYEDGQNDYDDLDDYEDSVVMEQDELAAIKGVYYEEDQEEEEEDNLSETSSIYSNSSDSDLDSDSDEYYIYSDSDEIIEENNIAIEATIPRNFKSLSIVPPPSSTTSSTTSTTQSPLPSIVRSNSTPITITSLHTIDEQQEIEEEKQPELLLHENNQTIDWKLKNHNHPQSLYKNQNISLDQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AIB7</accession>
    <name>Q5AIB7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C102470WA</name>
        <name evidence="2" type="ordered locus">orf19.10453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721435.1">
        <property type="nucleotide sequence ID" value="XM_716342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AIB7"/>
    <dbReference type="SMR" id="Q5AIB7"/>
    <dbReference type="GeneID" id="3636851"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102470WA"/>
    <dbReference type="CGD" id="CAL0000183813">
        <property type="gene designation" value="orf19.10453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02470W_A"/>
    <dbReference type="HOGENOM" id="CLU_1834906_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AIB7"/>
    <dbReference type="OMA" id="HLWIQYF"/>
    <dbReference type="OrthoDB" id="4021927at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000183813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18365" checksum="B0C5663EDF43FFD7" modified="2005-04-26" version="1">MDQDNEIDRLRETELWNNNNNISNTASDPNDLTLPSSITAFDPIQQQELEQLQALLDPSSSLSHNEEQQQQQQGQQHHLKNNETSQCWIRALIFIGYCISTVFFSIHLWIQYFFVKYTYDDQTAVNMLNYVTAAQEQAIDEYSRKTERRRSRESDQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2025-06-18" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJD0</accession>
    <accession>A0A1D8PJB3</accession>
    <name>DBP5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP5</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP5</name>
        <name type="ordered locus">CAALFM_C301860CA</name>
        <name type="ORF">CaO19.1661</name>
        <name type="ORF">CaO19.9230</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Nucleus</location>
            <location>Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Nuclear pore complex cytoplasmic fibrils.</text>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721738.2">
        <property type="nucleotide sequence ID" value="XM_716645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJD0"/>
    <dbReference type="SMR" id="Q5AJD0"/>
    <dbReference type="BioGRID" id="1219658">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AJD0">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJD0"/>
    <dbReference type="EnsemblFungi" id="C3_01860C_A-T">
        <property type="protein sequence ID" value="C3_01860C_A-T-p1"/>
        <property type="gene ID" value="C3_01860C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636564"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301860CA"/>
    <dbReference type="CGD" id="CAL0000188126">
        <property type="gene designation" value="DBP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01860C_A"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AJD0"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PRO" id="PR:Q5AJD0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000232219" description="ATP-dependent RNA helicase DBP5">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="183"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="361"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="540" mass="60206" checksum="1CB36CE3394A520E" modified="2017-05-10" version="2">MSSEKVKRVEADATDLLASLSIDKSGEKLEEIKKGSTPDPSDLLGGLSLKEGDSKKPEEKKEVVEEPENKEINDDKKDEDKKDESKDEVKDGDGAKEETKEEVKEESKEEPKEPKEPKEPATNLIKSSYEVKVKLADIQADPNSPLYSVKSFEELGLSPELLKGLYAMKFNKPSKIQEKALPLLLSNPPRNMIGQSQSGTGKTAAFSLTMLSRVDPTIKMPQCLCLSPTRELARQTLEVITTMGKFTNITTQLVVPNAIPRGSSVNAQVLVGTPGIAIDLIRRRQLNLSKMKVFVLDEADNMLEAQGLGDQAIRVKKALPRGVQLVLFSATFPTEVREYAERLVPDANSLELKQEELNVDGIKQLYMDCRSEQHKFEVLCELYGLLTIGSSIIFVEKKETADVLYGKMKKEGHTVSVLHGGLDNTDRDRLIDDFREGRSKVLITTNVLARGIDIASVSMVVNYDMPTDKYGKPDPSTYLHRIGRTGRFGRVGVSISFIHDRRSYDILMAIKAYFGNVEMTRVPTDDWDEVEKIVKKVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK00</accession>
    <name>Q5AK00_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C505270CA</name>
        <name evidence="3" type="ordered locus">orf19.11504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721929.1">
        <property type="nucleotide sequence ID" value="XM_716836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK00"/>
    <dbReference type="STRING" id="237561.Q5AK00"/>
    <dbReference type="GeneID" id="3636496"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505270CA"/>
    <dbReference type="CGD" id="CAL0000180118">
        <property type="gene designation" value="orf19.11504"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05270C_A"/>
    <dbReference type="eggNOG" id="ENOG502SGTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073623_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AK00"/>
    <dbReference type="OMA" id="PYPQYQR"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000180118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="303" mass="36259" checksum="6B8A7CBC6B19FADB" modified="2005-04-26" version="1">MSDLEYDRDVAMEEPQPYPQYQRPPPPRKIDFIGLDLPDIADPMYKSKPEQDLDVRYEVKEENEFHETRALFIGNLRRPINAAHFQSYLRDLAREEGSFIIERAWLSRARTHAIVLVSSEHGAVYIRSKLLNTVYPPKEEEKRLRLEFEEKEIERFEEQKRLYEQELGRLNEKEREALPPPLEPREYVTERIPLYVEYIPVKAINQWTFEEDRGPRDGKWKLEFEHRDGDTVASHTLLNSDYIPRYVPTRRGPPRRYNDRPYNAPPRRADSYVPNGTNRRTDTYIPSRDRNRSRSPSRSPRRY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK10</accession>
    <accession>A0A1D8PP56</accession>
    <name>PAN3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="1">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PAN3</name>
        <name type="ordered locus">CAALFM_C505170WA</name>
        <name type="ORF">CaO19.11493</name>
        <name type="ORF">CaO19.4010</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721918.2">
        <property type="nucleotide sequence ID" value="XM_716825.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK10"/>
    <dbReference type="SMR" id="Q5AK10"/>
    <dbReference type="BioGRID" id="1219427">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AK10">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK10"/>
    <dbReference type="PeptideAtlas" id="Q5AK10"/>
    <dbReference type="EnsemblFungi" id="C5_05170W_A-T">
        <property type="protein sequence ID" value="C5_05170W_A-T-p1"/>
        <property type="gene ID" value="C5_05170W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636464"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505170WA"/>
    <dbReference type="CGD" id="CAL0000174293">
        <property type="gene designation" value="PAN3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05170W_A"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AK10"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="PRO" id="PR:Q5AK10"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001869">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000295362" description="PAN2-PAN3 deadenylation complex subunit PAN3">
        <location>
            <begin position="1"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pseudokinase domain" evidence="1">
        <location>
            <begin position="308"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="1">
        <location>
            <begin position="616"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="577"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PABPC-interacting motif-2 (PAM-2)" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PABPC-interacting motif-2 (PAM-2)" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="416"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="470"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="697" mass="77933" checksum="10EDD83024188F32" modified="2017-05-10" version="2">MNINLDTAKDTLCKNILIYGYCKYENKGCAFSHNRQQPAQQQQATNTSNNSTSVITPNSANSTASSADLSSKKKFNLNTPSFQPSVSNLSNKFSTLSPKLKEIPVFKPENGVSEPDTVDSPTTQRPFTSKRFNVSTPSFTPTNFDFANNSNADGNRGGASTPIGISSAPLVQNQQQQQQQQQQQQKQPLAVPSPLASGAQPPTMQHRILSMGVSQSSPSTNPYFANNLDMSAPTPGSETPGPVLPGSAGAAAAAANQPMYPLQYHLYAPAPPPRLTIPLQPYETNSQAMFIPNDLREYLHKKNEASLQSLSHSNLPEHVNQYHSLVPIDKSYEPVSKLWLGKNSLIFKCLDNIDGNLYVMRKIEPCNEIINEKPFKTIKRWKSIKNANIVGLQDAFTTMAFNGNQSGNTSLCIIYDYYPNSISLLEHHKKGLRVEPVNEALLWNYLIQLINAIMAIHEKGLSASSTIDLSKIIVTNKNRIKLSSVGISDILEFKDDETNQDIKIRQLQDIQKVGKVLMELAILLLPVNMRQSNNIYNSLKASTNLSEEIINNLQELNDLDTASGEFDLNEFSQRLTPKMFNIIDSLQNSSDFIEGQLTSELENARLFRLMTKLNYLIHDNSNSENDKIIKLFLNYVYNCYDSNNKKVINLNKVLINLNKLDCGIDEKILLVNNDECIIISYKELKEIIDTKFRLMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK82</accession>
    <name>Q5AK82_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial 37S ribosomal protein RSM26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C504530WA</name>
        <name evidence="3" type="ordered locus">orf19.11420</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="262" mass="30772" checksum="C5272A97E0C8B9B2" modified="2005-04-26" version="1">MFNSISRGVFASSTRFTRVARFLHQVPKLESHETWTQEGIPGFLSPKGYNLAWTDYQNYLLTNLTLLTNGTSSEYKTPYQTLLHTAKQTTQQHVFHYASMAHNNHFFFQQLDTKENASKTKPSRFLMEKLMHEDILDLDQLRNKLLTMAENTYGQGWIFLVETEDKNLKFINCHNDGTPYYYAKQQLLDLNGGIDEGNFSYLENLKSRALNNEKDYTLPILAINYWDYMYIPDYGVTGKSDYLNKLWDHINWDVVNKRLFQI</sequence>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    </evidence>
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    <sequence length="253" mass="29152" checksum="55448A02E2D5E997" modified="2005-04-26" version="1">MIIVWLILSLFTSLCLSVSPDPNPSKIDRPILKISTRTHDKIIIINNLQEIANNISVGMTSYEKFNRLSSNEMRECVEGSCIKFYIREIKCTDRTFIASECRTNLNARFQSILQPTTNIHNLILRDEDSLDTQLKTNLVDHFSSFRQFKEFKFNDFNNNLNYDLQCLVDYQSLMQVHFKQTVVEVNLMGTTEVADACQFDKINPNFDGSRSVYTTTYLPVNGTFYCQKGKSQTCNRTIAESKNSRYKLPDICG</sequence>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <comment type="similarity">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000132">
        <property type="entry name" value="Nitrogen-sensing and cell-morphology modulator, general aminoacid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="62"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000178778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="559" mass="61659" checksum="934632071EA83D42" modified="2005-04-26" version="1">MSYPTPKKEQDSILSESYQSFSTASTKNPIKNFIYSFRVNRDLQVTSDEITTPDDLLKGYQVKLIALSSCIGSGLFISSASMISSAGPGGTVIGYFIVAILMFFIVQALGELTSSYPVRGNFLVYNTRFIDESWGFAMNWNYCLQWIVNIPLSLVAASLTIQYWTDKIDPAVWVAIFWVVIVGISIFGVKGYGYGESLFSVIKVVAIAGFCILGVILAAGGGEQGYIGGRNWHPPFVNGFHGICNTLVNSAFSYSGTELAAIAAAETSNPRKSLNKTIKQIFWRILIFYMLVIVIVCFLIRHDDPKLMGNSSWPVSPFVIAISNGGIKVLPSIFNAVILSALLSVANASVFATYKPLVALAEAGHGPKFLAYVDQKGRPIYSIIIALAFGLIGFVGSSSSQAVVFNWLLALSGLSCIFIWFSISLAQIRVNYACKVQGIDSKNVPFKAIGGDYGAYFSMLINVLILMAQFYVGLYPINGKSLNASTFFQAYLAVPIVLVFYVGHKLWTKNWSWYIKAKDIDITTGRNIVDSDFELQAMEFEKEMEPKKSIMHRFVNFWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AL47</accession>
    <accession>Q8NKD3</accession>
    <name>Q5AL47_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">SPC3</name>
        <name evidence="12" type="ordered locus">CAALFM_C113020CA</name>
        <name evidence="11" type="ordered locus">orf19.12396</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722141.1">
        <property type="nucleotide sequence ID" value="XM_717048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AL47"/>
    <dbReference type="SMR" id="Q5AL47"/>
    <dbReference type="FunCoup" id="Q5AL47">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AL47"/>
    <dbReference type="GeneID" id="3636121"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113020CA"/>
    <dbReference type="CGD" id="CAL0000195857">
        <property type="gene designation" value="SPC3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13020C_A"/>
    <dbReference type="eggNOG" id="KOG3372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068714_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AL47"/>
    <dbReference type="OMA" id="LHWNIQP"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000195857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="192" mass="21780" checksum="53D6FA8B6560FA77" modified="2005-04-26" version="1">MFNLVTRAQAAANSAFTSSIVITSVVIVLTLLQLYKDNVWSLNTTSITNIRPTASIKQSFHYGSLNRKPKENAKIQFDLSSDLTPLFNWNTKQIFIYLTAEYPGKSEGSSNKVTFWDKIITNKEDANLTLTNQRGKYSVWDVEKSFRGRNATVRLEWNIQPYVGPLIFGSTEGFGEFQFADTQKKKESTKNT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-02-22" modified="2025-06-18" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANB7</accession>
    <accession>A0A1D8PKC0</accession>
    <name>THI4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="1">2.4.2.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thiazole biosynthetic enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">THI4</name>
        <name type="ordered locus">CAALFM_C305130CA</name>
        <name type="ORF">CaO19.13407</name>
        <name type="ORF">CaO19.5986</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">During the catalytic reaction, a sulfide is transferred from Cys-210 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="1"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723197.1">
        <property type="nucleotide sequence ID" value="XM_718104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANB7"/>
    <dbReference type="SMR" id="Q5ANB7"/>
    <dbReference type="FunCoup" id="Q5ANB7">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANB7"/>
    <dbReference type="EnsemblFungi" id="C3_05130C_A-T">
        <property type="protein sequence ID" value="C3_05130C_A-T-p1"/>
        <property type="gene ID" value="C3_05130C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635160"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305130CA"/>
    <dbReference type="CGD" id="CAL0000199344">
        <property type="gene designation" value="THI4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05130C_A"/>
    <dbReference type="eggNOG" id="KOG2960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ANB7"/>
    <dbReference type="OMA" id="MFPRIVV"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="PRO" id="PR:Q5ANB7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000415871" description="Thiamine thiazole synthase">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <sequence length="354" mass="38170" checksum="19288EFF22340F66" modified="2005-04-26" version="1">MTPPTMLQTAPVESFNLNPKSTQQAINLKSDAKNGKVSFADWNEFKFAPIRESTVSRAMTRRYFADLDKFAESDIVIIGAGSAGLSAAYTLGKNRPDLKIAIIEASVSPGGGCWLGGQLFSAMVLRKPAHLFLDDMGLDYEDEGDYVVVKHAALFMSTLMSKVLQFPNIKLFNATAVEDLITRKDPATNLQRIAGVVVNWAQLDHDTQSCMDPNTINCNVVLSTSGHDGPFGAFTAKRLEQLGRAPRDVTAGFTKPSITTSKLQEPEPISNFQLGGMKGLDMNKAEDAIVKGTREVVPGLVIAGMELAEVDGSNRMGPTFGAMALSGVKAAESVLNVLELRKQQNEACYGAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AND9</accession>
    <name>Q5AND9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">ARF2</name>
        <name evidence="18" type="ordered locus">CAALFM_C304950WA</name>
        <name evidence="17" type="ordered locus">orf19.13385</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2017-01" db="PDB data bank">
            <title>Crystal structure of the ARF family small GTPase ARF2 from Candida albicans in complex with GDP.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) IN COMPLEX WITH GDP</scope>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723175.1">
        <property type="nucleotide sequence ID" value="XM_718082.1"/>
    </dbReference>
    <dbReference type="PDB" id="5UF8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.87 A"/>
        <property type="chains" value="A/B/C/D=1-181"/>
    </dbReference>
    <dbReference type="PDBsum" id="5UF8"/>
    <dbReference type="AlphaFoldDB" id="Q5AND9"/>
    <dbReference type="SMR" id="Q5AND9"/>
    <dbReference type="FunCoup" id="Q5AND9">
        <property type="interactions" value="1220"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AND9"/>
    <dbReference type="GeneID" id="3635271"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304950WA"/>
    <dbReference type="CGD" id="CAL0000178804">
        <property type="gene designation" value="ARF2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04950W_A"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="Q5AND9"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PHI-base" id="PHI:7009"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="126"/>
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        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
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    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="127"/>
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        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000178804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="5UF8"/>
        </source>
    </evidence>
    <sequence length="181" mass="20574" checksum="350CFBC1DC3DE61C" modified="2005-04-26" version="1">MGLSFSKLFANLFGNKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRYYFQNTQGIIFVVDSNDRDRIAEAREELQQMLNEDELRDALLLVFANKQDLPNAMNAAEITEKLGLHSIRQRPWYIQATCATTGDGLYEGLEWLSTNLKNSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q96WL3</accession>
    <accession>A0A1D8PHB4</accession>
    <accession>Q59LH8</accession>
    <name>URE2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein URE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">URE2</name>
        <name type="ordered locus">CAALFM_C204710CA</name>
        <name type="ORF">CaO19.155</name>
        <name type="ORF">CaO19.7794</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2001-08" db="EMBL/GenBank/DDBJ databases">
            <title>Prion characteristics of the URE2 protein of various yeast species.</title>
            <authorList>
                <person name="Fernandez-Bellot E."/>
                <person name="Baudin-Baillieu A."/>
                <person name="Cullin C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Proc. Natl. Acad. Sci. U.S.A." volume="99" first="16384" last="16391">
            <title>Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein.</title>
            <authorList>
                <person name="Edskes H.K."/>
                <person name="Wickner R.B."/>
            </authorList>
            <dbReference type="PubMed" id="12177423"/>
            <dbReference type="DOI" id="10.1073/pnas.162349599"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Darlington</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF260777">
        <property type="protein sequence ID" value="AAK51643.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF525173">
        <property type="protein sequence ID" value="AAM91946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710606.1">
        <property type="nucleotide sequence ID" value="XM_705514.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q96WL3"/>
    <dbReference type="SMR" id="Q96WL3"/>
    <dbReference type="FunCoup" id="Q96WL3">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q96WL3"/>
    <dbReference type="EnsemblFungi" id="C2_04710C_A-T">
        <property type="protein sequence ID" value="C2_04710C_A-T-p1"/>
        <property type="gene ID" value="C2_04710C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647795"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204710CA"/>
    <dbReference type="CGD" id="CAL0000198677">
        <property type="gene designation" value="URE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04710C_A"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_1_1"/>
    <dbReference type="InParanoid" id="Q96WL3"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PRO" id="PR:Q96WL3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000034">
        <property type="entry name" value="Transcriptional regulator URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017298">
        <property type="entry name" value="Ure2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037861">
        <property type="entry name" value="Prion_URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0534">Nitrate assimilation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000186004" description="Protein URE2">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal">
        <location>
            <begin position="195"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="344" mass="39136" checksum="09D18470BF36C0CD" modified="2001-12-01" version="1">MMSTDQHIQQNMNDNSNNSNNSNNNNTNNNNNNQSVNVNVNNTNNNTQTISNLSAGLKSVSLTDQQQNEVNLNLLQQQLHQEASTQQQQSRITQFFQNQPTEGFTLFSHRSAPNGFKVAIILSELNLPFNTFFLDFNNGEQRTPEFVTINPNARVPALIDHYNDNTSIWESGAITLYLVSKYLKENGECSLWSNNLIEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRFFDHPVWLVGDRTTVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKHMMQRPAVKRALRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PC70</accession>
    <name>A0A1D8PC70_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pol93p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">POL93</name>
        <name evidence="12" type="ordered locus">CAALFM_C100290WA</name>
        <name evidence="11" type="ordered locus">orf19.6078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719040.2">
        <property type="nucleotide sequence ID" value="XM_713947.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PC70"/>
    <dbReference type="SMR" id="A0A1D8PC70"/>
    <dbReference type="FunCoup" id="A0A1D8PC70">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PC70"/>
    <dbReference type="GeneID" id="3639299"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100290WA"/>
    <dbReference type="CGD" id="CAL0000175689">
        <property type="gene designation" value="POL93"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00290W_A"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PC70"/>
    <dbReference type="OMA" id="SECWDEN"/>
    <dbReference type="OrthoDB" id="4022548at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="334"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000175689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="653" mass="75606" checksum="1746DEA010C22D40" modified="2017-01-18" version="1">MDMEEFLDEARKGQVGMLLLKTEDDEDTAGMVDDKKDIMSVVQGTNKSYFAELIRNYKDIFKGELDQKPPSRGSWDPKIEVVPHISPPATRQYPLSVPEQEELRKQVKKMLEIGLISPTPPQSPGYNSPVLFVRKSDSSYRLCVDYRLLNLIIISKQFSIPRAEELVRDIAGHRFYTRLDMTAAFHQLRLEASSKYYTSFSAFGRRYHFNVLPFGLSISPASLCEVMSEVLDGIEGCKSYIDDIIVYSNTLEEHEEILRELFSRFRKYTFYLKPTKCSFGDTTTSFLGHEISSNGVSIPEDHLRTIRELKCPDTSKGMRKVMGFMNFFRGHVRNFAKMLMNEVFSVFGLPHKIISDKDIRFMNSVFDYIYEYYQIQMATTSTNNPAANGQVESINKSVVTVLRAYCGLESAHWSTYIKIVQFTLNTHWAKAISMTPYQAVFGRLPRDQYGLSDFYMNHSNADAAALVTRAQLIRTYIKDNLSRYYDDLEEKANKGKKDIVYKLGDLVLLHRDAYYTPFRYRKLTPVYYGPFKIVKVINDNAYELDLPKISKKDRVINSKWFRPYIMDKVAFRDVPRPGKESELRAAEISAILGIDYENQTLDVTWLGCRPNHATTVSLDWFNRFVPKYLRKTLYENAKSLFGDRIEFNQRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCI5</accession>
    <name>A0A1D8PCI5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C101530CA</name>
        <name evidence="14" type="ordered locus">orf19.10849</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718164.2">
        <property type="nucleotide sequence ID" value="XM_713071.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCI5"/>
    <dbReference type="SMR" id="A0A1D8PCI5"/>
    <dbReference type="FunCoup" id="A0A1D8PCI5">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCI5"/>
    <dbReference type="GeneID" id="3640232"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101530CA"/>
    <dbReference type="CGD" id="CAL0000176283">
        <property type="gene designation" value="orf19.10849"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01530C_A"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCI5"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
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    </dbReference>
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        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
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    </dbReference>
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        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="505"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000176283"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW25843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="622" mass="70793" checksum="C7567B323EAA05AB" modified="2017-01-18" version="1">MSVETISDSLKQLGLSQPAAIEGTHPQYNVVDVFRNYIAEELNRISSVDKSIIIQALDTPKVLDQGDIIVPIPKLRLKGINPNEKSKEWAENFNKGKFISEIKPQGVFLQFYFAKTLLYNLVIEDVLKRKSDYGYLPLGVGKKAIVEFSSPNIAKPFHAGHLRSTIIGGFISNLYEKVGWDVTRINYLGDWGKQFGLLAVGFERYGDESKLASDPINHLFEVYVKINQDVTKETSEATGETPAETIDASEQDEKKIQSSTNEEARRFFRRMEDGDESALKIWARFRDLSIEKYVDTYGRLNIKYDVYSGESQVPQEKMKEATKLFEDKGLIDIDRGAKLIDLTKFNKKLGKALVEKSDGTSLYLTRDVGEAIKRYETYKFDKMIYVIAAQQDLHCAQFFEILKQMGFEWAHNLEHVNFGMVQGMSTRKGTVVFLDNILQETKEKMHEVMQKNEEKYAQIEDPDKIADLIGISAVMIQDMQSKRIHNYEFKWDRMTSFEGDTGPYLQYAHSRLCSMQRKSGISIEELEHANFDLLVEPCASALARTLAQYPDVIKKAVKGLEPSTIVTYLFSVTHIVSQCYDILWVSGQEKDVAIARLALYEAARQVINNGMTLLGLTPVNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCJ4</accession>
    <name>A0A1D8PCJ4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C101630WA</name>
        <name evidence="6" type="ordered locus">orf19.10861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718176.2">
        <property type="nucleotide sequence ID" value="XM_713083.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCJ4"/>
    <dbReference type="SMR" id="A0A1D8PCJ4"/>
    <dbReference type="STRING" id="237561.A0A1D8PCJ4"/>
    <dbReference type="GeneID" id="3640194"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101630WA"/>
    <dbReference type="CGD" id="CAL0000177587">
        <property type="gene designation" value="orf19.10861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01630W_A"/>
    <dbReference type="eggNOG" id="KOG2435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCJ4"/>
    <dbReference type="OMA" id="WIKAVAQ"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="36"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000177587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW25853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="227" mass="25897" checksum="02FEDA3758941328" modified="2017-01-18" version="1">MSMKALGLNATKSIFAKQAELTRPVQSVLNFKREPEKSLDQVLTRSDQELGGYSTVNFDIDPKEHCGHFYGNLSLDLPKDNPQVTRSGYAMFRTKDQNQSWLFGDSFWDWTNYSSLVLRVKGDRRKYLVNIQANTPLVTDLFQHRLFLNHPGQWETVVIPLNDFVMTNWGVIQDGSELNKGEVKSVGIGLLDKHYGPYSLKIDWIKVMTGAEVAKVATKSRMERLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDN5</accession>
    <name>A0A1D8PDN5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C105900WA</name>
        <name evidence="3" type="ordered locus">orf19.9996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718481.2">
        <property type="nucleotide sequence ID" value="XM_713388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDN5"/>
    <dbReference type="SMR" id="A0A1D8PDN5"/>
    <dbReference type="GeneID" id="3639866"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105900WA"/>
    <dbReference type="CGD" id="CAL0000188476">
        <property type="gene designation" value="orf19.9996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05900W_A"/>
    <dbReference type="eggNOG" id="ENOG502RWFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDN5"/>
    <dbReference type="OrthoDB" id="4096756at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="393"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="AOW26254.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    <sequence length="972" mass="104796" checksum="A9DCD88ED8691400" modified="2017-01-18" version="1">MSEEEEDKHLKSPGGSSLNPRKSSDLQPSASSSSQTLDDTHSQPKSTTPSESTEYTSPSKSLKSFFFKNRLSSYSIDSISEQPELEFQSHRHSTERTRTKKSSSIGSAELSPSRSPRMMNFSLRPKFIRSRSSGISDTSTGSTHPIPPAASVLSSSSQRRATIEDFADTESEESNDSNEDIEDKNQDQTNANKQQREHHHHHQQQQSHDIDEDSINSLLQEYHNRDSEFDNKDIKNKFIFREEFDDTNSIKTKSRPASRILTPEENEELKAEIIRQGSIRSSGGTSSSSQILKPLGSGMSRGSSSQQQQQQPYIDTQIAQQYYGDARKHIEVVDPTKREKSNSVIATTVSGDSPTALKRLSGGSNSSGSSSANTAIGGGGGGGGSENRNSGASSATSLRFKIYNDKIEPIKHASAGKHMSTSTTNAEAAGISGADRSSMRVSTAFSDESETAGDAKYPEPTVTPIQTPRINRNSDTPSTDTNYTSNDTSGISYEAPLAIAGSLHKSSSTSSSSPNSGHRSSSSVPSTPLRTQHANQQHGSSNLQRSGGENLQETKTDADGTRSTGGTNTTSTGFFDETMLKGGSRKSVAHSSMSSGELLQNLEHSYDYSKSNDNSGNSDDTNQNQTKATTAQQIKQSTPIHEFVIKDAKKSPPMSSPPQIDTYPADKPSQSGEDEVFGTSIPRPMGVPKSDSVGQNMTAGLDSKSELPVMLFKVQDRDIQRDSKFFDNSNSHGQRKSGGGDGGVGGEDENQSLSGCDSESAGNIRESVSGSVSGSGSGSGNGSGTRSGCSSRGRLTIGSLSEAGNSSRSSGSSIKQIISRHFRSIGESLNTDEKQPQPESNSQDPSQQQPLRSLNLVKDSPPILFDEKNHIIMPSSKFDQESQQEPTKQTIDYPWINWSLLMLLGLIVPPLYFVIPIGLMDRDYLGLRYANKPSKKFTTTQKIISLILGILWLLIVLAMIGVGIGLGVTRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEI4</accession>
    <name>A0A1D8PEI4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Crp1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">CRP1</name>
        <name evidence="13" type="ordered locus">CAALFM_C109250WA</name>
        <name evidence="12" type="ordered locus">orf19.12248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718377.2"/>
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    <dbReference type="GeneID" id="3634826"/>
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    <dbReference type="CGD" id="CAL0000174668">
        <property type="gene designation" value="CRP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09250W_A"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="432719at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0015691">
        <property type="term" value="P:cadmium ion transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
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        <property type="term" value="P:copper ion transport"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:silver ion transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000090">
        <property type="entry name" value="AGL041Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGL041Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="170"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="254"/>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131634" checksum="878AA345AD84902C" modified="2017-01-18" version="1">MQKFIINFANIHCDKCEGIIRNVVSRYYKISDETDLNANIKPSEVIFKLENNEVTLYGNDLIDFHGDIKSIIKSLGKSGFDILSWDLHNGDETVSSSQIVNTNIQGANEPDGFIDIVGMYHKFINSRNKKKHMKYCKVCQESEQHKKKSTDSDFSSSSEDTVVEIPHQEFRASFLVTGMTCASCAQSITDNLRSILGESKKEDEPNFSVNVIQQSVVVIIPNKQIINKIVDAINDMGFDCKLIEVLPVQRSVNTKVTALIGGMTCAACANSIDSAVKELPFILESGINVVTKAAQFVLEDDGGSNIAKLKETIEDCGFDFELLSTEKVNYTSGKQKPRSINLKVNGMFCNHCPDIITQYLTNYGDAVVINDPISLDHPVIKFTYVPSQTLKTRKILFDLNHLKDDGNGGYTITPDEKGAFECEIIKPVTVDEHVRKLAHREVLGLAIRLAIATLFAIPTFIFGIVAMSLLPKHHPFRVWVEDPLWVGNVSRNSWILFILATPVYFFAADTFHRKAIKEIKSLWFHKNSFKSRLLKFGSMNLLMSLGTTVAYFASIVLIGLSATQKPMTHHGLHTTYFDSVVFLSFFLLIGKLLQSYSKSKTADAISELSKLKQTEATLIEDDKDTRVDIQLLEIGDQIRIGTGESPPVDCVLVEGSTEFDESALTGESTPVKHQEGHQIFSGTVNIGNSSVVGKVTSLEGDSLLNQIVNTVRDGQMRKAPMERTADLITGYFVPLIIACAVITWVIWLALGYSGALPQSYLDIDVGGWTVWSLEFAIAVFVVACPCGIGLAAPTALFVGSGLAAKNGILAKGGGVAFQDGANVNIVCFDKTGTLTKGELTITDFHFPDKSSIAKTFALQAARDLEVPSHHPLGKAVKSFVTSYDGKSLTANKIPQVETVPGKGLRGQIIYDEGDDIWNEYKPTQAILGNEKLMEENDIEFTEKERQWLKKWKGECKSVILVGLQCESYFKDSKFHLALIMAARDQLRPETKKVIEFLKHKDIECWMITGDNKLTADAIAKEIGIENVVSEVLPDEKEAQIKKIRQLNSGGKKEPVIAMIGDGINDAPALASADVGIALSSGADLAVTSSDFILLNKIHPLVSLATLLDICSKVFQRVKLNFGWSLVYNLIALPIAAGVIYPYKNSRLDPVWASAAMALSSVSVVLSSLALKLYKPSLKAEDFGVDDSTESELSPNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFE7</accession>
    <name>A0A1D8PFE7_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">CAALFM_C112470WA</name>
        <name evidence="2" type="ordered locus">orf19.7723</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000198128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="245" mass="27426" checksum="8BE09BD0469A50B2" modified="2017-01-18" version="1">MNKLIYSPIELLNLRHNYKYDIYLPELDISTQQQQQPFFPPPPITFPAKSSIRLYTNTANNNNLYPISAFVLIQQPLYCQSQFNSTLPNYYNSSHPPIQDLVQPIFISSPPISPISLSSPITPIAIPVIRIDSNRSVPFGGVPLSDLYTKKFQQQEFQQRTHQKHNCPIQGKQTKHSMSATFPLYNTPISPESKGNVLKPGKDKDQNVNPGNDKSESPLLHLSNSKTASSSSSQSTSSSDVIIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PFI2_CANAL</name>
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        <submittedName>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AOW26882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711574.2">
        <property type="nucleotide sequence ID" value="XM_706482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFI2"/>
    <dbReference type="SMR" id="A0A1D8PFI2"/>
    <dbReference type="FunCoup" id="A0A1D8PFI2">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFI2"/>
    <dbReference type="GeneID" id="3646834"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112670CA"/>
    <dbReference type="CGD" id="CAL0000180134">
        <property type="gene designation" value="orf19.13713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12670C_A"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFI2"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071001">
        <property type="term" value="C:U4/U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000180134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="911" mass="105676" checksum="07EA9DA6567D8D2C" modified="2017-01-18" version="1">MERKSFLDQEAPEGYVAGSARGAVGFRTSTSPDSFNRGIAIVQNEEEEEDEDNNNKTTTQLNENGILSTKKRGKEDEDDEEADRIYNEIEKKLQSKKRKSPNNKNDRAKPTVTTTNDNSSTQFSDLKRQLANLTEDDWLNLPEPGDMTRKNKRTRLLEQQQQRMYSAPDTLISTSSSATGTNTTNFKSLSESRDKLLGSQLDNLLPAYVKTNGQSINNSSSVSEELQQSILNMTGVEQDSKYANLQKNRVILSSLRKSEPYKPSSWISSARLEEQDGKNLKLAKQYILEGCKKCPRNDEIWLENIRLNQSDIKLCKQLITNALNYNPKSEKLWLKATDLETNNINKRKVLMKGLEKIPNNDQLWEKLIELENDPNMVKKLLLKAVQLCSQNWEFWSALLNISNYEESKKILNQARKSIKGVKNILKVWITACQLEEREYGEETIDINKLIKLMDKAMKEISIYQMTKDDWYKLACDSERENFKVTTKAIIISYLKFKGLDQSSIFEDVDKFFNDGYIIVAKSILDYIVTNSSNDINKWKKVFSVIKKFNQELPLLFSYYDKAISLNPQVPLFYLMYAKDKWQLSKDIPQARSILNSGELANPTDLSIKFAIIKLELKTGNLLNAEKYIKHIIDTKPMESEKFWYKYIHILRCLNSDITVLKDVIQKALKLFPNCWKLYLQNIQILEDIDELEQARENALVGVKKCPQCIYLWIKLSQIDEKAQIIIRARSILDQAILQNPNNPEIWVYKIQFEKRIGNLSSLQNLTNKALKQFPTDPWLWIINLSLIPKMSQRKTIFLDALKATNNSNLILLIIGVFFWFDGKYSKSKNWFERSLQSDNTNGDIWSWMYNYLKKFGTSKELNSFLIDYESKYDSINKGHFFNKINKDIKNYNKSPKEILDIVAIEVLNYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFN1</accession>
    <name>A0A1D8PFN1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tgl99p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">TGL99</name>
        <name evidence="4" type="ordered locus">CAALFM_C113510CA</name>
        <name evidence="3" type="ordered locus">orf19.12449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722188.2">
        <property type="nucleotide sequence ID" value="XM_717095.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFN1"/>
    <dbReference type="SMR" id="A0A1D8PFN1"/>
    <dbReference type="STRING" id="237561.A0A1D8PFN1"/>
    <dbReference type="GeneID" id="3636168"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113510CA"/>
    <dbReference type="CGD" id="CAL0000198798">
        <property type="gene designation" value="TGL99"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13510C_A"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFN1"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000198798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="542" mass="61991" checksum="DB2C55F9D8AD77F7" modified="2017-01-18" version="1">MPVHEEISLISTLFNVSLLISKIVFLYISSLLGVDSFITTGDVPISKSSSNQPDNNHLKTRLVNAKDINEIVETHGYKIREHVVTTRDGYLLVIHKLEKIQNNSYSHHHRHISSTANLSKIAYFHHGLMTNSELFVLGTNKYKTLPYLLVDLGYEVWLGNNRGNKYSRKHLKLSASDPKFWDFSLDEYSYYDIPDSLTYIKNYYHHINNNTSNNNNNNHTGSPTVLSSSTSTLTNSDLQIIYIGFSQGCSQFFASLSLYPQLNSHIKMFIGLSPAIIPQNLNHPIFKLLVNQAANDNSFLFSLFGRRAIMPSVSFWYTIFGPSLYEKVVDKSLQLLFGWTGANISQSQKEIGYPHMFSNSSVKSLLHWFQIIKAGRFQMFEETCCYGITKLSCLSHKSKQKGNRVAPFPIADHLDVPMVLFYGDNDILVDINKTKNLIVDNNHKMQDKLELVLCPGYEHMDTLWGENVYQDVFKPVLERLEKSEFSFGYNINGSNNRDSELLIEDNDRHQLNSKNLQLHENALDLDDVSLDMNNANEMKFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG38</accession>
    <name>A0A1D8PG38_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pdr6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">PDR6</name>
        <name evidence="6" type="ordered locus">CAALFM_C200370WA</name>
        <name evidence="5" type="ordered locus">orf19.9641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719540.2">
        <property type="nucleotide sequence ID" value="XM_714447.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG38"/>
    <dbReference type="SMR" id="A0A1D8PG38"/>
    <dbReference type="FunCoup" id="A0A1D8PG38">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PG38"/>
    <dbReference type="GeneID" id="3638824"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200370WA"/>
    <dbReference type="CGD" id="CAL0000183439">
        <property type="gene designation" value="PDR6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00370W_A"/>
    <dbReference type="eggNOG" id="KOG2022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PG38"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000183439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1004" mass="115125" checksum="69054D789DE4F59F" modified="2017-01-18" version="1">MSDELNIEGVARDIELLYSSSNALVIHELQERLQTYQKSEIGYQLGFKLLENSNKNVKYFGALTITVFLNTHDSSVIFENCFNQVLGVLIELSTTDFTGNLFIIKKLISNLSLLYIMNSEVANFDPVFRLLSAISGSKDTAMSTMISQLQDEKQLELLLLFLLILAEDIIKLPTQSPKLHTLIHNTVFKYCSVLFEYLYNNLPSISTRIILLSLDCLSSWVVYISVAETNSEERYNDDVQVFLQYLLKQLDIETNINNMEILNKSFTLFTEIIDNVPRILSPLRSTIFDILFGKNKFGTRYTKLICTSQEFRETYSLEIENYVNLVISYLGLNLVLITRNINDINVVNIIQMTMALSSIPGIPTEDENVSEQFIVFWEDFTETYIDDAEEMKPQFTADQDQANFIAKRNEILLEVSRIFFKKVLYYPAATKEFRSYRNSVAELFGSLYSLMGVSLYSSICDLICFNLDQQDRTTETFQNLEAGLYLIYKITSDIYFHDDHEEDDFGKVTLTPLINEMFNKHLVSVVEGAPEFVTKQLQITLLNVMSVLPFFYRNEVGSQHLPATFNFLFNIILNGANETISLIASRTVYKICQDSEEKLIPFLPNLELILLEMLKNPNIDDTIRERMTHSYISIARATKNPVDWGNRVHGVLMEIESCYSSLNEELEAYAVSLISCISEMSNASLLPEDVEDYLTLEQLNIHKAYWIEDPLEIRSKVLKNLKLFSLETNMLSRNSIVTEKCCNVLKYGFREELPGPFTFSVDIVFEYLVAKVQNCNTQSIPIIHGLLETIIITSFKTINPDATEILLNSIFIEIYSTIVSDVDLVKSSLDLFTTILEKRPALLLQTPFFSDTIIPFAIQPLYLHEIFVVKSVTKFWNTAITLKKGNSNDHQQIKDIINSSIQNTTIGVLLIEALLSGFVSAPRSAIEYYFPLFRTLIARMPLEVKNWIRHVLLNSSMGKAPLDSKESETFLNKLLLTRGQRQANDVLRDYWLQVNKLTNFIKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG85</accession>
    <name>A0A1D8PG85_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C200920WA</name>
        <name evidence="2" type="ordered locus">orf19.9580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="222" mass="25292" checksum="4B671D8990404A26" modified="2017-01-18" version="1">MYKLILLTWLCLLPIQMVSSSDSTKKLFPKTDVNDLVYFNQVFDMATKQTSDPDPDSYVENSNKTITLITLDKPPKNDTNAVDAQFKKKKGKLKPKWELNAGVYLEKKVNKKLLKKSKKKNSKKFGILTKDNGDAERILIPAELMVSRATPGTHNLFSQNSSNYPFQLTKINVTSIRKAPVLSTSIAHEVSDINHGIVEFSIASKLFDKFWNQIFWAFLYIL</sequence>
</entry>
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    <accession>A0A1D8PGH0</accession>
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        <submittedName>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
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    </dbReference>
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        <property type="entry name" value="Opi1"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000184732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="432" mass="47821" checksum="3B99596757E0945C" modified="2017-01-18" version="1">MTAPSISNQQLPPPPYSKTDNLPTSNYQSSLNGSVQGQDQQVQAQVQGQAPELVSAAETLTSLTRNGTPPSDADTVAMDDAQSPVILPPIHPQHQRHPIVSTVSMVARHPIVMNAVKYYETSKRNYPSFNYAAGIVESAAIPVVNNIEAKLNTRHQTRQASAVSSTDITPTNSNFGDYKIQHDGKNSLQKKRRFSASSQTTNISSYSSIDTKKRLQFCINILKLANTNISSKVEFLQEKIDETEIAVKEEREKLIAQKSHDSNSTNTTEQATQKTKTEIVGTVKKIIHLISNFRPSSLGDTSVTNGLSPVSSNGSQSNQDFELKNAIRDIIMSLPQSLQQQQQQQSGPPSNSQDDVIFKFAKESLVMISKLTQIFTEKLDQVEHWVNGDEEQEQKLQSQSQSPEGLEKQQEDEREEENLAAETKRMKLDGSV</sequence>
</entry>
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    <accession>A0A1D8PGM7</accession>
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        <submittedName>
            <fullName evidence="8">Ato7p</fullName>
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        <name evidence="7 8" type="primary">ATO7</name>
        <name evidence="8" type="ordered locus">CAALFM_C202470CA</name>
        <name evidence="7" type="ordered locus">orf19.9144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
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    </dbReference>
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            <end position="86"/>
        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000180296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="260" mass="27619" checksum="F9921D1EDBF3C35B" modified="2017-01-18" version="1">MVSASTAESKDVDSVGSPNGNNVTKVEISGDGGEFVILGNKKYYRHEIMSVLAHNAQSSSSKFASSTPLGLCAFAITTLVLSLYLLQARGIKTINVAVSLATFYGGVVQTIAGIWVFFSGDTLIFTALTSYGAFWLSFAAINIPTFGILAAYQKDMTQLSSALAFYLIAWAILSFIFMLLTFKSTVLLSGFFLCLTALFSLLSASYFVGSVALTKAAGAFGVIAVVAALYDTFALLATKQNSYFTLSVIPLPGSEAKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGN6</accession>
    <name>A0A1D8PGN6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="2" type="ordered locus">orf19.9153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722622.2">
        <property type="nucleotide sequence ID" value="XM_717529.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PGN6"/>
    <dbReference type="GeneID" id="3635856"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202550CA"/>
    <dbReference type="CGD" id="CAL0000186103">
        <property type="gene designation" value="orf19.9153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02550C_A"/>
    <dbReference type="eggNOG" id="ENOG502QU5V">
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    <dbReference type="InParanoid" id="A0A1D8PGN6"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000186103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="703" mass="79117" checksum="7425033E97AF400C" modified="2017-01-18" version="1">MVLKDDNPPPPYHLISKEDNQNNSNNDSNNDDDIEDTSEPVSQPKLEDFRSFKYSIESIFPKFDKTKVQDPKFIPTTTEALAHLKLLKAFAVMKSKVVRDADAPKDFQINQWKSFITMAVRRFIIFVSALKTLYIGNNGKTTHRSFEELNKKEEFENVMAHLLPPLDVIMVWHAFLLNPKAFYDTFSRNSFIDFAKYPLPLDRIDFYINNETFEYKVSETYQTNYIDLLKRFTNNGSDLIYHMNNFIMYEQYVIINCPTCKIAISDPIPLVTDGNKGFADSEFMAKKKYQQKSIDSTDCYCSHIEYLTHDQLRKLQLFHDIHASEPLPGINKHFSNFLSHPRFSNRNTSIINYTIKDEAKKFWDNSSISVSTVMVSVISATTKSSDIKKAILRDYLQFNLIHLTVPNNTISIGEDLVGCVLRQESFVKKMNTINWVHSTTAQEKLETSLVRYQRFFRMLTDKNLKRMLVPTLDIDLMWHTHQLWMYGYFHDCLNSPCHSAIDHNDKIEEAKLDNGFEYTSKAYKKKFKEDYSICYCQYCSELRATKREKIKSFFKSSRSDDKKLYSTFKSASSENPLVLESPSHISTHNSIQLPTHTAETRRLKKPVPWSTANSNSQFYVVSPIAPVAEAHSQFYGNGLCCSVTASCASGATCCQIASGGCGSSGGGCSSGGCGATAFGGGGCGGGGGGGCGGGGCGGGGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGX7</accession>
    <name>A0A1D8PGX7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">SED5-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C203410WA</name>
        <name evidence="12" type="ordered locus">orf19.8499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721003.2">
        <property type="nucleotide sequence ID" value="XM_715910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGX7"/>
    <dbReference type="SMR" id="A0A1D8PGX7"/>
    <dbReference type="FunCoup" id="A0A1D8PGX7">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGX7"/>
    <dbReference type="GeneID" id="3637412"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203410WA"/>
    <dbReference type="CGD" id="CAL0000198855">
        <property type="gene designation" value="orf19.8499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03410W_A"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGX7"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="8">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="9">
        <location>
            <begin position="344"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="11">
        <location>
            <begin position="603"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000198855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW27377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113723" checksum="F791AF49144E0463" modified="2017-01-18" version="1">MSHNQYQQSYTERSDNGANTAINGNELSENLHALNLDQPQSLSAQQQQQHSSKKKSRRPVRAFHTEFNSPIPTTSSTPAFPSSPIVAGYPQNYASVYGSPVVNSTGQFQQSPLVSQAQDHHHSQFATASNSTELDQTVLQDSRNFHQNHDLSLQEHRLDSQREYNTPDAQGTYKSFQTFTDTVPPEAGTQFHAIDQGNASSKFMRSTMYYVPESEQLRSATKLPMSITVRPFAPLLSTEEKVQTVDFSMNDPNNTPEDPLSIGPIRCHRCRAYVNPSMQFTHNQRFVCNICQFANNVVPSEYASILDGRGYRVDKFVRPELHKGVYDIVVPKEYNFGGPEKDSNPLHIVYLIDITENSMKQNLPILITDAIRATLFSYNNSSEDATNGCNHDRSYKTKVAIIAFDKRIHFFNLSSSLETTQISVSPDLEDPFVPFSEGLFVDPEESRFVIEDALNYIENLASQDRVSDSEPCFSAACRTASMCLDLFGGGKIISLLSNLPSWGPGGLKYKDNKTIGRTAAPEVEKKLFSADNEYYKLLAREFIEKSVGLDVHVVSHTPVDLSNVGWLASVTGGEITRWANFDFERDGRALTAKIYNSVKNISGYQGQLKLRCSNGLQVTQYYGTSSSISDTSIVGNIQDPVIPVLSEDSTFTILLEYDGKLSPKLDCHFQAALLYTDPNGVRKVRVINLVLAVSKSLEDVFHFTDENAVVTTIVRDTLSFVGQQSLLELRESINNKLVDIFTHYRAMNEFGHNRAKTLSNKMLFPDSLKHLPLYMLSFLKSTVMRASAGLTADARMADMYQMLTMPIERLMYHLYPALVELHSLQPEDGILDETTGFAKLPLYKDLTIRNLDRGIYILCNGERVYLWIDPDTNPMLLKDLFGSDVDDIKNINPMMDELPELSTEISQQTRCVVKYFQQQINGVSYPNYTGVYIIRKTIDPAEFLFKELLMEDELGNAVKTVNGPSFAEYLTSLHKAIRVKIDSDKSSQSIRQLVSNVEHGNETLAQRYIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGZ5</accession>
    <name>A0A1D8PGZ5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA-directed DNA polymerase eta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">RAD32</name>
        <name evidence="13" type="ordered locus">CAALFM_C203540WA</name>
        <name evidence="12" type="ordered locus">orf19.8485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720989.2">
        <property type="nucleotide sequence ID" value="XM_715896.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGZ5"/>
    <dbReference type="SMR" id="A0A1D8PGZ5"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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    <sequence length="640" mass="72336" checksum="5401C82AA27F2F00" modified="2017-01-18" version="1">MSVKQETRPLTIPLVTNPEVATTLSKFTFQNLDDLNDPKKAYLSPLATIALIDLNAFFAQVEQIRLNLTNQDPVVCAQWNSVIAVSYASRKFGITRMDTIASCKSKCPNVIIAHAAVYKKGESHWAYVEGLPAINKHKVSLDPYRRESRKILRVIGKSFDLTEKASVDECYIDLGREIYKRLIDLFPQLSRGSRDNPENSYANLPLIPPALPLNLKWEGEIINTEKEKSEDNDIVSPPVIEDWDDICFIIGSQILLEVRKDIFEELGYTTSAGLARTKQVAKLAAGFKKPDAQTIIRNSAINSFLTNFELTDVTGMGGKLGESIINKVNVPPQINSISFIRENFSDASIKEKLGGELGLKVYNIVRGINAIELQSTIEVKSMTSTKNFTSFVISNLFDAYDWLKVFAGDLHNRLIDLDNENMELSSTELSNKSKGIMKRPKTLTLGVLSKNGTRQTRQMQIPIHKDLDKMKDIFFENGCVLLREFLEFNTHISLLNNRTPAKEIFIWDPKKVKIMELINMSLTISKFVSVEDRFTLLKTTDTSFNKEEHIAKLFRDYEQAPGTIKYSSPPPPPPPAQKKRSKNGQLDIFESLKKKSKPGDFLEELIKTKKCSRCKLSVDDPVEHNDYHIAMDLSNKLNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH14</accession>
    <name>A0A1D8PH14_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dck2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">DCK2</name>
        <name evidence="5" type="ordered locus">CAALFM_C204040CA</name>
        <name evidence="4" type="ordered locus">orf19.8436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715847.2"/>
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    <dbReference type="SMR" id="A0A1D8PH14"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH14"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C204040CA"/>
    <dbReference type="CGD" id="CAL0000201528">
        <property type="gene designation" value="DCK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04040C_A"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH14"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057500">
        <property type="entry name" value="C2_DCK1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25338">
        <property type="entry name" value="C2_DCK_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1685"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1709"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1730"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000201528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1768" mass="200661" checksum="535CB9194017759B" modified="2017-01-18" version="1">MTWTPTSCFLKGVVIKPFKPKNKRLSSPESENLPLKNLYPGDQVYVFETNNSKWGRGYVIHPSIGNDLKVISIRLNEVDQSSVVFPMNRIKIIDNIDFCKITNEVSSETENDKPNTPKFPRDNNQQYLSIKNQIGCAVNELNGLVFASYACGEINVFNQLKNVYLKLYDYYLRYIHNLFNEIETIETITKLLNEVTKILARVPYKPSLSSSSMIWSEVASKYCYMLARDKSNGEILNLGNSIPPTIAKAQEELILTNNNSVNIPTQSQLTLAPHNFKEYKNSHLLVNITDVQGDSSTQSTGLHNLFLHVYLRNETKRLTEPFVFKTKSIDDLQKVETISSILFRNLPEDQFDQNVFMVFVLTEEISLMRRKTFANLKYIKKGVAAGVINISKVFTQNQPNFHFDIKLFGAPLGGGGKKSSKSSFSWGVLVDKLIRGNIEGLVASSPIVQQVSASVKLIKHSPFGLSTKTKFSKKHSNLPITMIKPMFFDPFTETTERLYILLGQLALKKKKNSTDLYSVEISAPNNETIKFSQATNQREKKIWQLVGVTSNECFGEFIKIDNISLKNKNKKLPIDDYLQLTVYINGVLSGQGHLHYKSGNKLVEYRSKPHAVEIFSTSKGNQIASIEVSSTYVGKLFNSEVTIDNILEYESLYHSGTPGIDGLSSSLELFQKVKKKHLIRRFPELLTSLFGIIIISGADTDSNNLQNLQENTFKAIVFLLNSVLFKPQQHGHFLQCFEDIFINQPRIAVFLWTKLREIYYRGETIWDSYSKSVAKVQEILIRFATKSIQGSWEFEEYNETVVQSYRAMAHFLSMKSSLLIEDQINLLGIVDLMLTNTMYFDKRVVLNWYETFIDAIRLRSFGGHEKLMEDQEHKIQISKLLLILRVLGTELNRDKDTRSTVLLKSIEWAVEGFPDVTDIESVRLACSILNKCCTVIYELLVEGETDIIEVCHFLFKLLPALSRTFLKYSHIGNSAQQKSFGTQLFPQVYPFETVAIDQSFTDVGFCEVLVELAVVIGFIARIDKEIAVDNDDRTLHLADLYSRDDMYTVIIAVNEICKYEYFPSHNWLSLQAIIAESSLCVLELLSPVIFQKYIMGISLDINLCGEFLSTLLKLAILDTVASEGLPVLARAASTSITCSIGARVELLIDKVWGRLGDYVNKHKLESSLATLVLDYDLIHNVVLYTLKCTQTRKTGSKLLISIMKNYNQIEVERQCIISLFDIYCNGLYEPCESDESGFINNLNEFSTTNESETDQISMLFDFVAYLSRFIRVLNRLIRVPDTVEFNDDKVVYKIQALLYLVNVGEPEPLREFVGDLYKETIAQKDHIQAGLYLELLASTFPWSHGEYVTASLIPELPIQTNFERREALLELSAEHYISGHNLSKAIDVYNFMLNAFKNETYDLLRLSRLHGKLSLRYMELEYQDTIQHSYCRVVFLGNGFPEVLRGKQRIYEGQPFEHFTSIQQRILSKFPGSALYKDDGTDGKNLTGKYLDITLVYPNKSESGHDKKSFSVLKKVPGSSSIFDLWTEETTFETKSSFPTLMNFNDIASYKVIKLSPLDNASRTINAKTSELLRLERSIHRSMTDQTKSRGLFLDLSRELAGTVDSPINGGVGQYRLFLEYIGESNNNQAGKIKTLQNAFDELTTILKRCLDLHGRIVPESMRSSHQALVELFEKNFNDRIEAAYSSRDESDSSSSSSDPSTRPVSGGISRSHSMTPSVATMPEPRLAKTVTSTTGSSDTSYTSGKSSFLSNSLSLKRRFRWRKNANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHB8</accession>
    <name>A0A1D8PHB8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lem3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LEM3</name>
        <name evidence="10" type="ordered locus">CAALFM_C205110WA</name>
        <name evidence="9" type="ordered locus">orf19.11026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714901.2">
        <property type="nucleotide sequence ID" value="XM_709808.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHB8"/>
    <dbReference type="SMR" id="A0A1D8PHB8"/>
    <dbReference type="FunCoup" id="A0A1D8PHB8">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHB8"/>
    <dbReference type="GeneID" id="3643456"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205110WA"/>
    <dbReference type="CGD" id="CAL0000187500">
        <property type="gene designation" value="LEM3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05110W_A"/>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHB8"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015247">
        <property type="term" value="F:aminophospholipid flippase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044088">
        <property type="term" value="P:regulation of vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF20">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE ACCESSORY SUBUNIT LEM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000187500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="439" mass="50168" checksum="F0C06CC9C48418C6" modified="2017-01-18" version="1">MSRTADDAQQIDNGDQQREGVLDEYAQEGEYESSSDYDDESFVDKKEKSRRPKENSFTQQRLKAINPVLTAKTVIPLLVAIAIVFVPLGAAMWYASHKIEDITIDYSQCQNLARFDYWSEIPDNFTTYNFRNIDTNSESKPKFSWKLTNDTSQQFDDEKLVCQVQFEVVEKMKGPIYLYYRLHNFYANHRRYVKSFSEDQLNGKPATLNTIKNTVGQNCQPLSDVNGKRIYPCGLIANSLFNDTFTEAFEAVNGTSSDNTLVLTDKGIAWSTDKNRFKKTQYNYTEVVPPPNWYKKFPNGYNETNIPDISTWYQFQNWMRPSALATFNKLALRNDTGSLERGIYQINVGLHFPVLPYKGKKYLYITQRSVIGGKNDFLGISWMVGGGVCFILGLALLVINFVKPRKTGDVNLLSWNQEKTKRDEQSAAAAEGVTTGFEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHW6</accession>
    <name>ZCF10_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc cluster transcription factor ZCF10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ZCF10</name>
        <name type="synonym">QUA1</name>
        <name type="ordered locus">CAALFM_C207230CA</name>
        <name type="ordered locus">orf19.9820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2017" name="Genetics" volume="205" first="559" last="576">
            <title>Zinc Cluster Transcription Factors Alter Virulence in Candida albicans.</title>
            <authorList>
                <person name="Issi L."/>
                <person name="Farrer R.A."/>
                <person name="Pastor K."/>
                <person name="Landry B."/>
                <person name="Delorey T."/>
                <person name="Bell G.W."/>
                <person name="Thompson D.A."/>
                <person name="Cuomo C.A."/>
                <person name="Rao R.P."/>
            </authorList>
            <dbReference type="PubMed" id="27932543"/>
            <dbReference type="DOI" id="10.1534/genetics.116.195024"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probably acts as a transcritpion regulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is negatively reguled by the ZCFs master regulator of ZCF29.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714869.2">
        <property type="nucleotide sequence ID" value="XM_709776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHW6"/>
    <dbReference type="SMR" id="A0A1D8PHW6"/>
    <dbReference type="STRING" id="237561.A0A1D8PHW6"/>
    <dbReference type="EnsemblFungi" id="C2_07230C_A-T">
        <property type="protein sequence ID" value="C2_07230C_A-T-p1"/>
        <property type="gene ID" value="C2_07230C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643485"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207230CA"/>
    <dbReference type="CGD" id="CAL0000180150">
        <property type="gene designation" value="ZCF10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07230C_A"/>
    <dbReference type="eggNOG" id="ENOG502S3FG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHW6"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463340" description="Zinc cluster transcription factor ZCF10">
        <location>
            <begin position="1"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="27932543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="27932543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="921" mass="103363" checksum="F43FE0119835E6BD" modified="2017-01-18" version="1">MSESEDPNKKRKRIRRACDFCRSKKAKCDGKSPVCSNCFANKEECIYSQPVKRRGLPTGYTHDLEKKVRLFQGLIARLCEDKYVQSRLQTILNDESLVDDLVELEKSWNSNSISELFDQVASQSNSKNNIAKLATHKPTPVQSDSTPVSTLDGNPPLTTSQCQVCQKSQDRKFRKAHTPDPSQTISASPSTSQTATAATAATAAATVAADNAINPVIGSDRPTSIYPSTPSPFVSDSAFFLNYDVFQFISDEIEGVENPENWEPVALQYHGLSSIISGFTNKVVQQYNSKLNNVFKNPFRVGSIFNISSFAINASMTNKFQMPKEIFQFPINIRELVDIYFQVHQCYIPMLDRVSLIRHVNYLQSLPEHKRGSMDGNILALVWAVVALGEFSSIGGSVKKSSIFAKNAIMALENSFTTTIETIQAMITLGLVYYHLGQWDFSWVLISSGTRMAIDVRLMRNASDEDNPRVQSSASLNNINRQRTWATVYFVNTLLCARMGRSPVVRASDWPVPEINNDGWEEWSPWECYYAPNEIKLESGKFLSTFNETLKGVYILNLAITSTIDTSRGYYQNGEVKSEFKINYDDRQNSNNMTLEMFNDMIDAWSNQLPESFKDDQSNTGLKSPSTTILVLLRGLIWCVLAVRLSSLKGNSEIKDQIIQFRNQKYTEAIVAMKRCINENSENIWKHYFLFDYFLIMTFNFPYMMNFESEFMKYAHIQEMKNILVSCSETSIPCSICWDLLKIMNNGTKQRESSKLHDTPKAQESPTIANLLNDQADTEAVGPQPPTEVQPVASVPPMAPVAPNSSLTSVAPAPESAPAQVAAPPLVMAPAAPPISSSGNAPYISNDKNWVNQFGPPTTMLQDLHQVQSQPIYSNSNFHQQHKYYPHQISLEEPTSSLLQVNQIKQENTTSQPNNHNPNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHX3</accession>
    <name>A0A1D8PHX3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="14">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">TOR1</name>
        <name evidence="20" type="ordered locus">CAALFM_C207330WA</name>
        <name evidence="19" type="ordered locus">orf19.9459</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Vacuole membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="14"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714879.2">
        <property type="nucleotide sequence ID" value="XM_709786.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHX3"/>
    <dbReference type="SMR" id="A0A1D8PHX3"/>
    <dbReference type="FunCoup" id="A0A1D8PHX3">
        <property type="interactions" value="1201"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHX3"/>
    <dbReference type="GeneID" id="3643480"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207330WA"/>
    <dbReference type="CGD" id="CAL0000187577">
        <property type="gene designation" value="TOR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07330W_A"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHX3"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038201">
        <property type="term" value="C:TOR complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000748">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000750">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 14 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1337"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="2105"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="2450"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1782"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1782"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1804"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000187577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW27731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2482" mass="281335" checksum="E6B9AD798C50111D" modified="2017-01-18" version="1">MSASASTSAQLQVVDGVALTEIFKGLTSTSEEERSKYAEELHNYLSSIARDLSSEQFNRYNNDINKTIFDLLHGEKTSEILGGIAALNALIEFDSGVGKENAGKTARFSNYLGSLILSNDLVIMKQAIRTLGKLATLGGNLTGDFVDFEAKRAIEWLQSDSKQHENRRHAAILIITSLADNASTLLYPLINQVLENLWTPLRDHKLIVREDAAIALEKCMHIIYDRDVNARSFWIKRMIESASKLLNENDAADGADSNSSYNITFSGQSTENIHGSLLTYRELLKYYKDPFIVSRFEQIYENTYLYKNHKVAIIRQELTNIFPLLCKVNTELFVEKYLHRTLYYYLSQLKKYKSQNNETANTDKSAIFKSIGLIALEVGNQMATYLDAILDNIREGLSYTSNAGVQSILAKAASNESPNISTTNIASLASGSKYTASRKETEPAIFDCISKLSIAVGPALTKHLQRDILDMMFANCSLSKHMQDVLQVLIENIPTLTNLINEKLLNLLSLVLSGKGFQPPGSPFGTIKVNASLARDCRLIMISRDTGMSINTILMNQERYEKLDSKILIQALEMLAFFKFENYQLNEFVRYCTITYLEHNNAKVRLTATVTSCQIFVKDPICQQVSVNALNTVNEVLGKLVSISITDPAPEIRLAGLNCLIKAGNFDPQLSQANNVRLLFIALNDEVFGVRKVAIQILGRLSCINPAYIVPSLRKTLIQLLSKLEYSTTSRKKEESAILLSLLISNSKELTRPYVKPIVDALLPKAKDLSSSVASSAIKCLGELSVVGGEDLKPFIPDLMPLILDTFQDQSSSYKRDAALRTLGQLAFSSGYVIQPLLDYPQLLGMLVAILKSETSPDIKRETVRLLGILGALDPYKHREVEQNSKNIPVEQNAPPVDVALLMQGMSPSNEEYYPKVAITNLMKILKDPSLSIHHTKVIQAVMYIFQTLGLRCVAFLPQIIPGIINVMHTCQLSMLKFYFQQLGDIVLIVKQHIRPFLDDIFKVIKEFFNAGSQLNIQVTIINVIQSVSRALDGEFKMYLPEVLTLMIGVFEEDKSAKRSPSLHVLKSFVVFGSNIEEFVDIIVPHIVKLFETGPVELRRAAIETIGRLSKNIMLNDMASRIIHPILRILGQGNIDLRESCINTLTYMLVQLGPEFTVFIPVIKKTLLQKNIHAIKFEQLVGKLIGGDPLPLHLDIYKDYDYSLYDIADTDMPSKKLPVNQASLKAAWDASQRRTKEDWQEWIGRLSKELLLQSPSHAIRACAGLASDYYPLAKDLFNASFASCWSELYSQHKEELVESFCIALSSPSNPPEIHQTILNLAEFMEHDDKPLPMSISTLGQYAQRAHAFAKALHYKELEFYDQPTTPTIESLISINNQLQQSDAAIGILKHAQLHHDLQLKETWYEKLQRWDDALKAYNEREKIEPENMEITIGKMRCLHALGEWEQLSELARSKWDNSSSEIKRSVAPLAAAAAWGLSQWDRMDACIKVMKAESPDKAFFNAILSLHRNNFDDASVHILKARDLLVTEITALVSESYNRAYGVVVRVQMLAELEEIIKYKCLPSGSEKRAVMRKTWNTRLLGCQRNVDIWQRMLKVRALVIKPKQDMDMWIKFANLCRKSGRLNLAEKSLNLLLEEGSPENPSRAPPQVVYAQLKYMWAKGQRPEALRHLVDFTTRMSQDLGLNPNDLITQPLPSEGPGIPKHVEEYTKLLARCFLKQGEWQIALNSNWRSETSEIILGAYLLATHFDNKWYKAWHNWALANFEVISLYTSQNTSANNKIEILQDERNGSTEDGHSELKRAEQQKQQQQQQQQQQQQANIIPIEAVQRHVIPSIKGFFHSIALSNSNSLQDMLRLLTLWFKFGGIPEAAKAMTEGFNMVKIDNWLEVVPQLISRIHQPNEIVSRSLFALLTDLGKAHPQALVYPLTVAITSESTSRKKAAQSIIEKMRVHSPSLVDQAELVSRELIRVAVLWHEQWHDALEDASRFFFGEHNTEKMFETLEPLHQMLQKGPETMREQAFANAFGRELTDAYEWVLNFRRTKDITNLNQAWDIYYNVFRRVSKQVQSLASLELQYVSPDLKHAQDLELAVPGTYQAGKPVIRIIKFDPTFSIISSKQRPRKLSCRGSDGKDYQYALKGHEDIRQDNLVMQLFGLVNTLLVNDPECFKRHLDIQQYPAIPLSPKVGLLGWVPNSDTFHVLIKGYRESRSIMLNIEHRLLLQMAPDYDFLTLLQKVEVFTSAMDNCKGQDLYKVLWLKSKSSEAWLDRRTTYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPERVPFRLTRMLNYAMEVSGIEGSFRITCEHVMRVLRDNKESLMAILEAFAYDPLINWGFDFPTKALAESTGIRVPQVNTAELLRRGQIDEKEAVRLQKQNELEIRNARAALVLKRITDKLTGNDIKRLRGLDVPTQVDKLIQQATSVENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHZ3</accession>
    <name>A0A1D8PHZ3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NAM8</name>
        <name evidence="7" type="ordered locus">CAALFM_C207520CA</name>
        <name evidence="6" type="ordered locus">orf19.9432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713133.2">
        <property type="nucleotide sequence ID" value="XM_708040.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHZ3"/>
    <dbReference type="SMR" id="A0A1D8PHZ3"/>
    <dbReference type="FunCoup" id="A0A1D8PHZ3">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHZ3"/>
    <dbReference type="GeneID" id="3645207"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207520CA"/>
    <dbReference type="CGD" id="CAL0000179925">
        <property type="gene designation" value="NAM8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07520C_A"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHZ3"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="83"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="179"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="295"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000179925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="452" mass="51222" checksum="82764E0A723EA443" modified="2017-01-18" version="1">MSTYQNSGYRPRGYSSGYPSRSRGGGSGGGNNRGGSSRGRFNNGYQQTSHTSYRQRQTPATSSYKARQNVYQQHSTPLRNNDFQMWMGDLDPQWTEESIDNLWTKLVSKPHHVKIMRDRLQPSKPSYCFVTFRDQESIDLAIQRNGQKVPDSNRVFKLNYSGRNSTGSHDRSTNSSNEYSIFIGDLAPEVSDAALYNKFNMKYPNQIKQAKVITDSSTRKSKGFGFVKFHSPDIMNRALKEMQGYNIGSKAIRVGLAAGSHVDTSFKPVTKLDHHRVPVPQSQPALNQFTDPNNTSFTIGGLSGRITESELEQHFIGFGDLVYCRVSKDYQTGYIKFYSRSAAESALLNMYGFMINDCRLQITWGSCVQVSGASVNYLPNVAGEIYEKAKKSPAIYHHPNYPYLRFDKLSSDEIKKLPQRLDGSDVLTTSQIDEFYLNNKRYREKLLNDALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI44</accession>
    <name>A0A1D8PI44_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C208380CA</name>
        <name evidence="4" type="ordered locus">orf19.9008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710147.2">
        <property type="nucleotide sequence ID" value="XM_705055.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI44"/>
    <dbReference type="SMR" id="A0A1D8PI44"/>
    <dbReference type="FunCoup" id="A0A1D8PI44">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI44"/>
    <dbReference type="GeneID" id="3648253"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208380CA"/>
    <dbReference type="CGD" id="CAL0000188846">
        <property type="gene designation" value="orf19.9008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08380C_A"/>
    <dbReference type="eggNOG" id="KOG1929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI44"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="350"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000188846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="716" mass="82391" checksum="65F0AF64F063DB59" modified="2017-01-18" version="1" fragment="single">MSLKPFTGLLFCCTGLESTTRREVVEKIETLGGIHYSDLMTDVNYLIVGDRDTEKYRFCIKYRPDIIFIDADSIFTIHKHWINGEDENSDLLRIEKYRLAIFAQLNACFSRIEMSTSQIDHLVNTVKFRQRTNTSPEYFRPKNLFKLFVDNGGIAKESLSCHQNFIITADPRGTRYNKALEWNVPAIHPIWIVDSVLRGAALDWKDYILNNNPNDCYDRGCDVWPEVFDCQEKQKQKSQQQPKRLESTEPEVKRKITNNKTNADIWNSIMDHTKKQTKQLIHDKTWDDDEEEEDNDDDGDTQTKNEKNNQYKNITTIPKDGKQKPELNGKIHNLDLKLVSESKENSPNVSESQLFLGFNYYTVGFDSREFDLLSKAIENYSGEISNDPNDDSITHVVIPAKKGYQSMSVLKVLPADLKSRIANGFVKIVTEFFIERCMFYKKIILDRWGQPMKGLVPSKKSFKICTTGFTGIELLHIEKLIRSFNFEYCETLSEQRDLLILNVNLFKKSLMNSPKLFQYKCKDIINCPTGGSVSLMSSKHKVEAAKRWNIPVVSVAYLWEILELSTNKSHIIMPDITDLQWCVFAPSNYNKPKSLLEYVKNLDKASRESSFSPKSQENEALEEPTMDNSVRLPSPRRVNSKQKYGKLVGGKSPKSIKRKLLEAANSFADGQNDHSINPDVTIEEDSMSQIRYQDNESMINQERLLEKLDGSAVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIF8</accession>
    <name>A0A1D8PIF8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="5">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LEU42</name>
        <name evidence="13" type="ordered locus">CAALFM_C209750WA</name>
        <name evidence="12" type="ordered locus">orf19.8955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714549.2">
        <property type="nucleotide sequence ID" value="XM_709456.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIF8"/>
    <dbReference type="SMR" id="A0A1D8PIF8"/>
    <dbReference type="STRING" id="237561.A0A1D8PIF8"/>
    <dbReference type="GeneID" id="3643808"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209750WA"/>
    <dbReference type="CGD" id="CAL0000201867">
        <property type="gene designation" value="LEU42"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09750W_A"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIF8"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="571" mass="63427" checksum="47BE35E9CA3C016E" modified="2017-01-18" version="1">MLKDPSVKYKKFPNVNLPNRQWPSRSLDKPPRWLSTDLRDGNQSLPDPMSISEKKEYFKKLVDIGFKEIEVAFPSASQIDFDFTRFAVETAAEDVSIQVLSPCRPELIGRTVESLKGAKRATVHIYLATSDCFRNVVFGLSKEESKALAVKCTKLVRQLTKDDLSTAGTDWDFEFSPETFSDTDLDYAVEVCEAVKEAWGPTEDKPIIFNLPATVEMATPNIYADQIEYFATHITDRETVCISLHPHNDRGCSVAAAELGQLAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVSPKLDFSDLNSVIDIVEKCNKIPVHARAPYGGSLVVCAFSGSHQDAIKKGFSAHEKKKEKAGGKEVHWQLPYLPLDPEDIGRTYEAIIRVNSQSGKGGSAWVILRNLELDLPRGLQIAFSKVVQARAEVKGQELTNEELCELFKQEYFIDYDDEAPEQYFKLVDYSISTPSKGIKEIQADIEVDGKVISIKGEGNGQLSAFNNAIAKYLNIDIDVKHYHEHSLGEDSKARAATYIEVLVDKKVARWGVGIHTDVSQASFLSLISILNGLHKNKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ22</accession>
    <name>A0A1D8PJ22_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ato1p</fullName>
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    <gene>
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        <name evidence="9" type="ordered locus">CAALFM_C300920WA</name>
        <name evidence="8" type="ordered locus">orf19.6169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="13"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="265" mass="28366" checksum="FC3335576A01E984" modified="2017-01-18" version="1">MPSTSSQKSVGSSVMDPNEPPVGKVEVSGDGGEFVVINRHKYYRHELMAAFGGTLNPGAVPWPKININPAPLGLCAFALSTFVLSLFNAQAMGIKIPNIAVSLALFYGGLAQFLAGCWEFVTGNTFGMTALTSYGAFWLSFGAIFIDSFGIVAAYEKSEETVPQLKNALGFYLLAWAIFTFILWLNTLKSTVAFCALFFCLFVTFILLAAGEFSQKTALARAGGVLGVITAIIAWYVALAGTATTTNSYFRPISIPMPGNVAFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719963.2">
        <property type="nucleotide sequence ID" value="XM_714870.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PJH5"/>
    <dbReference type="GeneID" id="3638411"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302750WA"/>
    <dbReference type="CGD" id="CAL0000192677">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02750W_A"/>
    <dbReference type="eggNOG" id="ENOG502TBA8">
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    <dbReference type="OrthoDB" id="4091783at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="58108" checksum="A9EA6F554DF79B5A" modified="2017-01-18" version="1">MITTRIRPIMNNTSTHTNTKTSTTILAKRSATATTATTSIPKQSSMSGQSKHAILIPSALNSLLHTDKQIKYHFYSLGGDFIRLASYRRFKQLFQVGGGSLVKQFVFDLSTFLKEELNDINSLRHHQLKNFLTCNKTILEKEKSMTLCDHHFGLKNWLYIIFGYMLQNYNEQEVNNCLDQLVSMYLEARSNRFSINDIRIIRDERDQFILSTFEQYLLDVPVRNDLLYNDNGDNKDVNYIILSNIKHHKHSNKNATIASNKDNNTTNRINLPKLPKIKDKSLLVKSLMHKEFYRVLLDPNHYFGKKMLGRNYSLDPQDYSLIRKELSILDGLGDLFLAQETSKLIYELICQKNHININSSTTYQLLKIMLATNTLMAKLTKAYNLYQGLDDSIINKRIAKEWLPFTILGETPPHSESSDWQSKDEIRIYEEEFLGDFFESYMAALLIEQPEVAKSFIREIYHRILMVMTETLPPDITYQTWTSNILGRNIYRKKSESIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKY7</accession>
    <name>A0A1D8PKY7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">HIS4</name>
        <name evidence="23" type="ordered locus">CAALFM_C400140CA</name>
        <name evidence="22" type="ordered locus">orf19.13084</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713320.2">
        <property type="nucleotide sequence ID" value="XM_708227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKY7"/>
    <dbReference type="SMR" id="A0A1D8PKY7"/>
    <dbReference type="FunCoup" id="A0A1D8PKY7">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKY7"/>
    <dbReference type="GeneID" id="3645025"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400140CA"/>
    <dbReference type="CGD" id="CAL0000177625">
        <property type="gene designation" value="HIS4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00140C_A"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKY7"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000002">
        <property type="entry name" value="Histidinol dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="207"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0000177625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AOW28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="838" mass="91900" checksum="973C93EF50A56738" modified="2017-01-18" version="1">MIFPILPVISSPEDKQSIDEFSLVGQVLFPIESVSPKKHFIHQFPHDLDIFVNAIDNATTDQIVELLNVGIKQVFVNEKQYHDAIEAGSPSSRFVVAVDVPSTELLTSEASFVTSKPFSESDLKKYNANENRVIYIESNFTQDGAIELAKNYVPVIPSTKLTVKREEENKISISAVFVSTLTTDRPDGLYTTLITTPSPSYTALGIVYSSKDSIIAAIEEKVGVYQSRKRRDELWYKGKTSGATQKLVKLSKDCDSHVIQFMVEPRTGYGFCHRETKFTCFGDDIADSPARGLPKLDSTLQDRLENAPEVSYTKRLFDDEKLLIAKLKEELDELIEAKSKEEIAWECADLVYFAMVWCIKHGVRLADIEKNLDVKSLKVSRRKGDAKPQYQEAPVNSSYKLEIVSVDDAAAVERAMTRPVQKTADIMKLVLPIIEKVKSDGDKALIELTSKFDGVKLDAPVLQAPFPADLMDISEEMKAAIDLSMQNIEKFHAAQLPKEKVMTVETSPGVYCSRFAKPIENVGLYVPGGTAVLPSTAMMLGVPAKVAGCKNIIVASPPSRATGKLTPEVVYVAHKLGAKCIVMAGGAQAVTAMAYGTESVLKCDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADSNADADFVASDLLSQAEHGVDSQVILIGVGLSDEKLNEFQAAVERQAKVLPRKDIVAKCLAHSYILLAKTYKEAFDLSNQYAPEHLILQIDDAPSYVPDSIENAGSVFVGALSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQEVTEKGLQNIGKAVMELARVEGLEAHRRAVEIRMERMAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL36</accession>
    <name>A0A1D8PL36_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C400590CA</name>
        <name evidence="9" type="ordered locus">orf19.11660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in endocytosis and clathrin cage assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with PAN1 and the clathrin heavy and light chains CHC1 and CLC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AP180 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712638.2">
        <property type="nucleotide sequence ID" value="XM_707545.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL36"/>
    <dbReference type="SMR" id="A0A1D8PL36"/>
    <dbReference type="FunCoup" id="A0A1D8PL36">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL36"/>
    <dbReference type="GeneID" id="3645772"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400590CA"/>
    <dbReference type="CGD" id="CAL0000184462">
        <property type="gene designation" value="orf19.11660"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00590C_A"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL36"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="375"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00058079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000184462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="668" mass="76176" checksum="7D591FC997D53709" modified="2017-01-18" version="1">MTTYEKIVKGATKVKVAAPKPKYIEPILMATSLDHSLISKENFNTIMRTLQARLHDSSWSVVYKALIVIHLMIREGDKNVTLDYLSNQASPNLLNLNNNNIIKNSNSFNSDIKFITRYAKYLHTRVKQFESTGVDYVRDERSNNNTNQQGGRLRLLDVDKGLLREVESVQKQIDSLLKNNFMENEINNDIVLTAFRLLVNDLLALFQELNEGVINILEHYFEMSKIDAERSLKIYKKFVDQTKFVIDYLRVAKHLEYATKLHVPTIKHAPTALTSSLEEYLDDPNFEINRKQYLAEKKGKDNIVSKPTQSILNKKSKNEPGQQQQQPREQQQKLQGTSSDLNRHSSLVVQQTYNPWNTMFVPIVGVVDPSQQDQAQQQAQQQAQQQAQQQALQQQVQLQQAQQQALQQRATQQATQQQQQTLFSQLPSISQGKTLQSTFTGVGFGGYGSQPQQLQAQHTNPFIQPSQQLQQPQQPQQPIGLQRSNTNPFSSMATGQHQVSQQQFAQPYSQSNMNQQPQPLQAQSTNPFANTRFASTSHTTAFTLDNGSIQPQQQQQQQNQNQKIQANATGNNPFKVSQTTSQLFDNYASTQQQNQHQQLKPQATAGGLEHLPTIPVFPETQQEAQRQFYFQNAQTGLYNQAFQPQPQQQQQQQQQVQQYNYHDGPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLD5</accession>
    <name>A0A1D8PLD5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C401710CA</name>
        <name evidence="2" type="ordered locus">orf19.12093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722695.2">
        <property type="nucleotide sequence ID" value="XM_717602.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLD5"/>
    <dbReference type="GeneID" id="3635708"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401710CA"/>
    <dbReference type="CGD" id="CAL0000182167">
        <property type="gene designation" value="orf19.12093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01710C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PLD5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000182167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="142" mass="16314" checksum="A94F5673ECB10A5F" modified="2017-01-18" version="1">MQVNQRKQQKSYKMRLFSNKFNQNNNNNLNNSHYKNNNVMDYTTNNQPNKDINKTIINNKVNTPSNSNNNNNNKQVNQHNNNNNTITMVNINNNNILNKQLNQVLNLVVIQDSTIMLTTNKLLSSSSSPLQSLVMLLQLVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMI5</accession>
    <name>A0A1D8PMI5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C406160WA</name>
        <name evidence="4" type="ordered locus">orf19.10438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715575.2">
        <property type="nucleotide sequence ID" value="XM_710482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMI5"/>
    <dbReference type="SMR" id="A0A1D8PMI5"/>
    <dbReference type="FunCoup" id="A0A1D8PMI5">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMI5"/>
    <dbReference type="GeneID" id="3642819"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406160WA"/>
    <dbReference type="CGD" id="CAL0000201128">
        <property type="gene designation" value="orf19.10438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06160W_A"/>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMI5"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002504">
        <property type="entry name" value="ADR009Wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001545">
        <property type="entry name" value="CAP-Gly domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000017">
        <property type="entry name" value="Pac2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000201128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="502" mass="58182" checksum="DDFB2E16016AB6A3" modified="2017-01-18" version="1">MINKYSLNDRVSTIDNYLGTIRYIGNLPVWGTNTVALGIEWDDPSRGKNNGDLNGIQYFTPKVTGSGTFIKSSNRSLNHIRKSFVQIIHENYLDTEYKTKNIQFGIKTVEELGWDKLNKFHSNLRNLDSLTLDYCLINIAYHDNEDKQLFDELVNLTNLELSCNLFTDVNEICKIIDNIPSLTSLNINGNRFSQFSQEQRTHNGIVSLKLSSTMMSTSMLEKLIKKFPNLKELYISGNNYCNADIENMNLNMPLTILDLSYNRLEHMPILPLVSALNLSHNYLSLRIIKGTFPNLKSLDLRANQIKDWTEIDKISIHLPDLKELRINHNPLFQELSVDDMTMQLIGRIKCSPEHLWKLNGSFLTNEEIENSELYFISKVEQGKYHIDNEQQWSYLLSKYNKLVESRVSYTYTLKDWMPLTIVLPDSKEISKKFTKNTSILQFKGLLSSWMNDLSILKFSAYYYTNENSTFAEKHELTNYLSTLDSYSLSYDQRIYISIEASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMS5</accession>
    <name>A0A1D8PMS5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cta6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">CTA6</name>
        <name evidence="8" type="ordered locus">CAALFM_C407070WA</name>
        <name evidence="7" type="ordered locus">orf19.10614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715411.2">
        <property type="nucleotide sequence ID" value="XM_710318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMS5"/>
    <dbReference type="GeneID" id="3642907"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407070WA"/>
    <dbReference type="CGD" id="CAL0000182389">
        <property type="gene designation" value="CTA6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07070W_A"/>
    <dbReference type="eggNOG" id="ENOG502T0MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMS5"/>
    <dbReference type="OrthoDB" id="4023481at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000182389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="213" mass="24498" checksum="A76DED2AF5E58BFB" modified="2017-01-18" version="1">MSRDGTFSYIHLDDPNKVLYIERWKDEPITYDDIETSNLVEAAVNVYPQLFAEEEEDDGILNFPSQQFGSKLYKNRRSIKQKRWMDLNIESFKSDNKNVVDKTLVPPVAGDPDLAEFLSNGYNKEELSVLQLSPGNNTVLHNSDMSLNSTSDYVGNSNNTFINMRSNSTSHQQPSQQQQQQQQQQSQFQTPRPGRVRQVSTDKFQTPVSRIMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-05-10" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN14</accession>
    <name>GIT4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycerophosphocholine permease GIT4</fullName>
            <shortName evidence="4">GroPCho permease GIT4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycerophosphodiester transporter GIT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GIT4</name>
        <name type="ordered locus">CAALFM_C500870CA</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="33939" last="33952">
            <title>Glycerophosphocholine utilization by Candida albicans: role of the Git3 transporter in virulence.</title>
            <authorList>
                <person name="Bishop A.C."/>
                <person name="Ganguly S."/>
                <person name="Solis N.V."/>
                <person name="Cooley B.M."/>
                <person name="Jensen-Seaman M.I."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
                <person name="Patton-Vogt J."/>
            </authorList>
            <dbReference type="PubMed" id="24114876"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.505735"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT3 (PubMed:24114876). Does not possess detectable glycerophosphoinositol (GroPIns) transport activity (PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:24114876). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:24114876).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)</text>
            <dbReference type="Rhea" id="RHEA:32911"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:32912"/>
        </physiologicalReaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">16 uM for glycerophosphocholine transport</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text>Expression is positively regulated by the transcription factor PHO4 (PubMed:24114876).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Triple deletion of GIT2, GIT3 and GIT4 impairs the uptake of glycerophosphocholine (GroPCho) and reduces virulence in a mouse model of blood stream infection (PubMed:24114876).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715742.2">
        <property type="nucleotide sequence ID" value="XM_710649.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN14"/>
    <dbReference type="SMR" id="A0A1D8PN14"/>
    <dbReference type="STRING" id="237561.A0A1D8PN14"/>
    <dbReference type="GlyCosmos" id="A0A1D8PN14">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="A0A1D8PN14"/>
    <dbReference type="EnsemblFungi" id="C5_00870C_A-T">
        <property type="protein sequence ID" value="C5_00870C_A-T-p1"/>
        <property type="gene ID" value="C5_00870C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642635"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500870CA"/>
    <dbReference type="CGD" id="CAL0000176164">
        <property type="gene designation" value="GIT4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00870C_A"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN14"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001406">
        <property type="term" value="F:glycerophosphodiester transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000439801" description="Glycerophosphocholine permease GIT4">
        <location>
            <begin position="1"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="532" mass="59246" checksum="B7D55072FBB9D024" modified="2017-01-18" version="1">MATRDLPHSVGDFCFGWVDQIRSEITLGKSQDQLIKEDVLEDDETVETKVEIKNLWPAFASGAGLFSDGYVNAGISTVLSCLKKIYGDEFTKSNAMNNIGSIGFVGTVVGQLSFGYISDNFDRKTGMLTANVMLIFFTLMCAVASWGTTVQGFFACLTVWRFFLGIAIGAEYPTSSVIASEFANQLPSGHRNRYFSWFTNAMIDFGFVVSSFVPLVLLWIFTPRHLRAVWRLSIGLGVIPPLILFFIRLKMDNSKSFKKMNMKRVNYSKYPWWLIIKFYWFRLTVVSLIWFIYDFSVYSFGTFNTIIIGEVIPNGTLYENWGWSVVFNLFYMPGAFLGAFIGDYLGPRLTLAIGVGAQGIIGIAMSACLKSLKKHVAGFVVVFGIFSTFGEFGPGNNTGLLASKTCASSIRGQYYGIAAAIGKIGAFVGTWVFPAIQKHYAYSEDLSLQVPFYVSSALCLFSAFLTIFFVPPVGQDAINKEDRLFKEYLEENGVDIRLLGDSGVVTQYQEDEDIGVISDEKDDTVKVQQKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN15</accession>
    <name>A0A1D8PN15_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C500760WA</name>
        <name evidence="5" type="ordered locus">orf19.8209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714206.2">
        <property type="nucleotide sequence ID" value="XM_709113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN15"/>
    <dbReference type="SMR" id="A0A1D8PN15"/>
    <dbReference type="FunCoup" id="A0A1D8PN15">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PN15"/>
    <dbReference type="GeneID" id="3644122"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500760WA"/>
    <dbReference type="CGD" id="CAL0000177296">
        <property type="gene designation" value="orf19.8209"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00760W_A"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN15"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000054">
        <property type="entry name" value="GTPase-activating protein gyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="218"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000177296"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="604" mass="69417" checksum="B89FCAE8733BD162" modified="2017-01-18" version="1">MVTTENVSSEIKITTTTPNELLDPNNNISTLDKSNHQRNESSYSQNFSVLREYDIETLSHRNSMSEDEIDQELPDPSFTNEIDNLELSQGTSNDDSSTQINNCESSEEERRSNRDSFVKPTNSETDQQILKSDCDRYGFKKTSSVTGLTLDEYNEWFKSYSQYSQARKKKWLVLMKNNGLHVDDSDTESFNNNNNNNNNIPTRFPPRSDKVKKMIRRGIPPEWRGNAWFFYAGGYEKLSKNVGTYERIVKATYNVKTKDTEVIERDLNRTFPDNIYFNSSIKGVFSSLETLQQEKEQETLLIKSLRRVLVAFAQHQPQIGYCQSLNFLAGLLLLFMEEEKAFWMLVILTERIIPKVHSANLEGVHTDQGVLMLCVKEYIPQLWQVLGKNFDGETLSEDKILSRLPPVTLVTSSWFMSVFVGILPIETTLRLWDILWYEGSKTIFRFSLTIFKMCSDSPEFNTKQNRRSGSGSGGGGESEQIELFQFMQNFPKKILDANLLVDLCFKKIGGYGFGSLSQDEINKCRAFVSKQREKLTKKSNQKGLTDMTDEERNTLLKSSTGFETSDIHDVYGFNRSIMSGMVWNKNISNKMKKKFVVGKRNNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNC7</accession>
    <name>A0A1D8PNC7_CANAL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="ordered locus">CAALFM_C502080CA</name>
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        <name evidence="3" type="ordered locus">orf19.10669</name>
        <name evidence="2" type="ordered locus">orf19.11692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2016-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Candida Genome Database"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">SC5314</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">SC5314</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709485.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720527.2">
        <property type="nucleotide sequence ID" value="XM_715434.2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="83"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000180850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000182697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="127" mass="13325" checksum="DC7B6DBDC6024683" modified="2017-01-18" version="1">MSDAGRKNISTKINEAITPESEKSTLEKGKEQVTSTLDKAVGSNVPDNQKSFTQTVADNVQQGSDNAKADLKKQSEQAEGEAKTLAETAQEYVEVAKTEIGKAAEYVSGVVTGATEGAKTGADSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PNE5_CANAL</name>
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        <recommendedName>
            <fullName evidence="5">Phosphatidyl synthase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">CAALFM_C502380WA</name>
        <name evidence="2" type="ordered locus">orf19.11721</name>
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        <lineage>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720555.2">
        <property type="nucleotide sequence ID" value="XM_715462.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNE5"/>
    <dbReference type="SMR" id="A0A1D8PNE5"/>
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    <dbReference type="GeneID" id="3637794"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502380WA"/>
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        <property type="gene designation" value="SRG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02380W_A"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000201">
        <property type="entry name" value="Piso0_001792 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
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        <location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="704" mass="76104" checksum="FAC742517165BFC1" modified="2017-01-18" version="1">MAQFHSIVQSNGPPPTLSGSRISTQQHNIQQQPGMINTSFNGNQQVDSNMTTGLLKISNLPPDLTRREATLIFALVIEEMLSIEIKDYQIYAVFKNINTCITTGKLLDGKYIFGTDYPPIKVEYENSTLLGSPTNISSTQSAFNSLRLSGPPNTNISPPNLPHSQLQHQSSSNSIDNGNSSSTGSFDMLSKRQSIGNQRSRFVFSDPFAQDQSQHQSHQQQQQQQQQQQQHHHHHHQQQDPHAKQEIIGIQPAGSGPPSVGPAPIGLSDMSGKSILLMESQNDAREYENLVRDSWGPTPGNSGVSAVSANSSTSGVDWNGNSSASNGSNIIQQQQQQQQQQQPPPPQQIQPDRRRTSSSAFFNVAPALHTMTSNQNIPNTHLGPTAAGLRAILQQPENQPQSHDSQLQAHSQSQLQSQLQSKTQPQPPSQPQSQSQLHIQQSQAQQHHQQQQQQQQQQPNTQSQIAPQTSNTSSITNEFHAPPNISQQSITSNQNTTSTSTSTPTQQAITSPLDKGSTSSKDVPDLSLLARVPPPANPADQNPPCNTLYVGNLPPDATESELRTLFSPQKGFRRLSFRTKNQSSSNNGTGSGGGSGGGGGHSHGPMCFVEFEDVAHATRALAELYGRALPRPNGGNGKGGIRLSFSKNPLGVRGPGNSRRTSTNPAPNGLSQSQQQQSSQSQSQSQQQGSSGGGNYGYSNYHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR91</accession>
    <name>A0A1D8PR91_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">CAALFM_C703140WA</name>
        <name evidence="2" type="ordered locus">orf19.12606</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="OS12G0206100 PROTEIN"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="723" mass="81977" checksum="8DFBBAAEDAA35B1E" modified="2017-01-18" version="1">MSSTDIGATLFARLVDNQSDTIPIIVNYLPKCMLPELLDISSVRNAAASTILSNVNITDSVSRHENIYGDDNSYNKCKCVQFDIEPANLKRGVDQWGIYPTKIHFDGMEQFQNIFENFPEVLQNARSINGSFYCLEGENSKRILREMVSSNVKFEVLKLFEFGDMGSVPLFVKDLDLVNTKLDTTCISGLQRFYSNTKKINTPLLNYSFISRLEQLSITTNTPTEVSLPQSLRKLTVDSCNGTISLSCEESNNLKELLFRSMNTKSFVETGIMAPNLKVLRLANCYDLTDFDSLKGFTQLEELSIKDTIYPIGLFDAISFPKLKSFTYGGVENLFESSHVWLSSESLPEEFNNPILKFPPNLTSLHIEDADYFKINLDTLVFPVSLTDLRLSQVLLSEGEIPLNENLESIFIDTPKLTFSGEFTLPKSAKKFTINADHLTFQGSRFLKELPTNLSSLSLKAYESGEMKTPVGKIKWPSSLKSLALKRFDLNHKTFKMLNLRDSKLEDIDIYKCKLEKLDVHALPTSVVDLKLVNVGIENLPPSLERLEKLKHLTLRKNRFGNLVPVKLPMKSLETINVSRCYLRTVSPLLVSMKEKRFSKTRLEITAWNNPNLAVDDVLKSLKTIKGLTVIVSRLDDDNFMIVSRLTASQRAEKINIDFHPDNPELNYLMEANLCYDSDQIYCGSEISLDDVEDENGDDYEDEVEVESDDNGEYTYYDEGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRJ6</accession>
    <name>A0A1D8PRJ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor eIF2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">SUI3</name>
        <name evidence="7" type="ordered locus">CAALFM_C704130CA</name>
        <name evidence="6" type="ordered locus">orf19.7161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715210.1">
        <property type="nucleotide sequence ID" value="XM_710117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRJ6"/>
    <dbReference type="SMR" id="A0A1D8PRJ6"/>
    <dbReference type="FunCoup" id="A0A1D8PRJ6">
        <property type="interactions" value="1199"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRJ6"/>
    <dbReference type="GeneID" id="3643130"/>
    <dbReference type="KEGG" id="cal:CAALFM_C704130CA"/>
    <dbReference type="CGD" id="CAL0000188940">
        <property type="gene designation" value="SUI3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_04130C_A"/>
    <dbReference type="eggNOG" id="KOG2768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRJ6"/>
    <dbReference type="OMA" id="CMREGNK"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="281" mass="31079" checksum="573592AA515C1462" modified="2017-01-18" version="1">MSDLGFDPSLKKKKKSKKVASVVDDTDSKESTPQPGDASVDDLFSGLKKKKKSSSKKSAEESGSPSVDEDLSSSLGDLTLKKKKKKSTKSLDLNEFEQQLEEAGVEDITESTNGATNDQSAIGLSYPDLLSRFFDILKKNNPELAGDRSGPKFRIPPPIVQREGSKKTLFANVQEIATVLQRSPEHLIQYLFAELGTTGSIDGEKRLILKGKFQPKQMESVLRRYIIEYVTCKTCKSMNTELKRESANRLHFLSCKACGSTRSVSSIKTGFQAQIGKRKKF</sequence>
</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW30974.1"/>
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</entry>
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            <taxon>Dikarya</taxon>
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            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG2241">
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    </dbReference>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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    </evidence>
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        <source>
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    <sequence length="369" mass="40932" checksum="C21A7A19BEE99C88" modified="2017-01-18" version="1">MSDLIAKFSKISLADISKSDSSKFPELSAEQKALASQFETLANRLNEQESLIALNDSLRTKTFIVGNIPSHADLVVFEKVFSLASQWTSKDDVAKYRHILRWADLVQNTLVNVPEPIKINYDIDIPREIKEKKKPAKEAEKSATPEPKAKATPDAAQGQRKELTEEEKKAKAAAKEAKKAAKAKANAEKNKQQQAPVATPPNPSMIDFRVGFIEKAEKHPNADSLYMSTIDMGDAEGPRIVCSGLVKYIPIEEMQKRYVVVVANLKPVTMRGVKSCAMVLCASDAEKVEFVNPPAGSKPGDKIFFEGFNGTPEKQLNPKKKVWEAVQPHFSTNENYEVTYTEEGKEPKRLVNEKGELCKNSSIVKADVK</sequence>
</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="266" mass="31069" checksum="E8CDF14F4304FD7E" modified="2017-01-18" version="1">MTIKDIKLTISKIKFNLDEINNLQEERNNIYDLDLTPSKNDNFEMISLISKTRQYFTFIEQDMNDYFDNLEKNGILDEFMNLVNQYTKIFEELSNDTNIDISEYKYVYKLPTPSQNGTEANPVQKSVRFKDTPDDNDASELMGTRHTFQPYKDDPDEDSSVEHEDISDHQMFAQHQQTLMRQDQDLDVLHQSISRQHMMSQDINHELDDQLIILNDLEQGVDSSLGHLNSANTRLRHFRTLMRENGSLVTICTLTVILILLLVILN</sequence>
</entry>
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            <fullName evidence="5">UBR-type domain-containing protein</fullName>
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    <reference evidence="7 8" key="1">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_04350C_A"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="448" mass="51408" checksum="45754BAB38B69D0C" modified="2017-01-18" version="1">MSEKIVQSSNDEAATLTAVDYIQNQEELEKEARELMPYDPNECTYEMGELRQPLFACLTCSAENENQPIGVCYSCSIQCHSQHELVELFTKRSFVCDCGTTRMKNTKDGACKLRRHGKKESSGRKLSNSSATHSTYLELAAEDIPSSSNTYNQNYHGRFCGCKQVYNPLEETGHMIQCYFGFTCGEDWYHDRCVMGITFADEKANQKHGNSQEESVPDGTNIKTDISKAQSESADIDSIEKLQYFPKLETFDEFICWRCVTSFKDVFEDLDKHFPGVILSKLPRFSNTSTVEDWYAKREKLLEPCFKKIKIEESSGKLGEFHNQEYSLFLSNDFRFKLIDNYESLDHESKLYKFLLNNSFLFKDDPIFKPPEDDSEEDCYSSSNAGTGRALETLPRDKAIESIQAYDKIKSKLKDFFKPFAEQGKVVTEEEVRNFFGHIDDKNNDSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSY2</accession>
    <name>A0A1D8PSY2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR05130CA</name>
        <name evidence="10" type="ordered locus">orf19.8255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_706894.2"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_05130C_A"/>
    <dbReference type="eggNOG" id="KOG0724">
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        <property type="component" value="Chromosome R"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="DnaJ domain"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111369" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
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            <begin position="42"/>
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        </location>
    </feature>
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            <begin position="260"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="300" mass="34975" checksum="F41CE5FB134FE5E9" modified="2017-01-18" version="1">MKFIKVFLLFVTIVVAAHWSKEDYEIFSLNDKLQQDLGHDITFYKWLGLEKGPKSNLQEITKAYRKLSRKLHPDKFASASRSDKKKANERFQRLSLVGNILKDQSLKRRYDYFYTKGFPKWKGTGYYYSKFRPGVIFTLIILYVLVGFLHFFSLKINRKQAFKRIVDLKNEVKNQAWGGLQFPPGDGSDRKLSNEATGKVFLVKADGTVWLVENDGEQHLIDEYDVNVNPGFKESLFFKIPVKIWNLILGKWVPIDTSVEYKKQETSPQEDDTKKKVQKKKSKGKKVELPNGKVVYSRKK</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="8">Potassium transporter TRK1</fullName>
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    </protein>
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        <name evidence="8" type="primary">TRK1</name>
        <name type="ordered locus">CAALFM_CR07960CA</name>
        <name type="ordered locus">orf19.8233</name>
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    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="55060" last="55072">
            <title>The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5.</title>
            <authorList>
                <person name="Baev D."/>
                <person name="Rivetta A."/>
                <person name="Vylkova S."/>
                <person name="Sun J.N."/>
                <person name="Zeng G.F."/>
                <person name="Slayman C.L."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="15485849"/>
            <dbReference type="DOI" id="10.1074/jbc.M411031200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TRANSPORTER ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Antimicrob. Agents Chemother." volume="50" first="324" last="331">
            <title>Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides.</title>
            <authorList>
                <person name="Vylkova S."/>
                <person name="Li X.S."/>
                <person name="Berner J.C."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="16377704"/>
            <dbReference type="DOI" id="10.1128/aac.50.1.324-331.2006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="FEMS Yeast Res." volume="9" first="278" last="292">
            <title>Conservation and dispersion of sequence and function in fungal TRK potassium transporters: focus on Candida albicans.</title>
            <authorList>
                <person name="Miranda M."/>
                <person name="Bashi E."/>
                <person name="Vylkova S."/>
                <person name="Edgerton M."/>
                <person name="Slayman C."/>
                <person name="Rivetta A."/>
            </authorList>
            <dbReference type="PubMed" id="19175416"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2008.00471.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TRANSPORTER ACTIVITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>TOPOLOGY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2021" name="Biochim. Biophys. Acta" volume="1863" first="183486" last="183486">
            <title>Regulation and activity of CaTrk1, CaAcu1 and CaHak1, the three plasma membrane potassium transporters in Candida albicans.</title>
            <authorList>
                <person name="Ruiz-Castilla F.J."/>
                <person name="Bieber J."/>
                <person name="Caro G."/>
                <person name="Michan C."/>
                <person name="Sychrova H."/>
                <person name="Ramos J."/>
            </authorList>
            <dbReference type="PubMed" id="33069635"/>
            <dbReference type="DOI" id="10.1016/j.bbamem.2020.183486"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>TRANSPORTER ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5 7">Potassium transporter that mediates K(+) influx, as well as Cl(-) efflux as a secondary function (PubMed:15485849, PubMed:19175416, PubMed:33069635). TRK1 is the major K(+) uptake transporter that regulates membrane potential and intracellular pH (PubMed:33069635). The TRK1-mediated Cl(-) efflux should serve as a Cl(-) detoxification route and may play a role in sustaining C.albicans on mammalian epithelial surfaces, or in physiological saline solutions such as saliva (PubMed:19175416).</text>
    </comment>
    <comment type="function">
        <text evidence="3 4">Mediates candidacidal activities of cysteine-free peptides, but not of defensins (PubMed:16377704). The hallmark of salivary gland-secreted histatin-5 (Hst 5) killing of C.albicans is the rapid efflux of cellular ATP and other small nucleotides and ions from the cell as well as concurrent intracellular uptake of propidium iodide (PI) (PubMed:16377704). TRK1 is the channel for Hst 5-induced killing and histatin-5 may directly or indirectly alter TRK1 function, allowing the efflux of larger anions, including ATP, and the influx of small cationic dyes, such as PI (PubMed:15485849, PubMed:16377704).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5 7">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="3 5 7">
            <dbReference type="Rhea" id="RHEA:29465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3 5">
            <dbReference type="Rhea" id="RHEA:29824"/>
        </physiologicalReaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">TRK1-mediated chloride conductance is blocked by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6 7">Induced during biofilm formation (PubMed:22265407). Expression diminishes when pH was altered, either to acidic or to basic conditions (PubMed:33069635).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Abolishes salivary gland-secreted histatin 5 (Hst 5) mediated killing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714227.2">
        <property type="nucleotide sequence ID" value="XM_709134.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTL7"/>
    <dbReference type="SMR" id="A0A1D8PTL7"/>
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        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTL7"/>
    <dbReference type="EnsemblFungi" id="CR_07960C_A-T">
        <property type="protein sequence ID" value="CR_07960C_A-T-p1"/>
        <property type="gene ID" value="CR_07960C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644153"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07960CA"/>
    <dbReference type="CGD" id="CAL0000190529">
        <property type="gene designation" value="TRK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07960C_A"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTL7"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:chloride channel activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:chloride transmembrane transporter activity"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0868">Chloride</keyword>
    <keyword id="KW-0869">Chloride channel</keyword>
    <keyword id="KW-0407">Ion channel</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000459222" description="Potassium transporter TRK1">
        <location>
            <begin position="1"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="10">
        <location>
            <begin position="68"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="intramembrane region" evidence="10">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="10">
        <location>
            <begin position="91"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="123"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="10">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="10">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="intramembrane region" evidence="10">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="10">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="10">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="711"/>
            <end position="754"/>
        </location>
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    <feature type="transmembrane region" description="Helical; Name=5" evidence="10">
        <location>
            <begin position="755"/>
            <end position="778"/>
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    </feature>
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            <begin position="779"/>
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            <begin position="811"/>
            <end position="817"/>
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            <begin position="818"/>
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    </feature>
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            <begin position="842"/>
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            <begin position="875"/>
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    </feature>
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            <begin position="910"/>
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    </feature>
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            <end position="942"/>
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    <feature type="transmembrane region" description="Helical; Name=8" evidence="10">
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            <begin position="943"/>
            <end position="965"/>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="180"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="571"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
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        <location>
            <begin position="428"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="16377704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="19175416"/>
        </source>
    </evidence>
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            <dbReference type="PubMed" id="22265407"/>
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    </evidence>
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            <dbReference type="PubMed" id="33069635"/>
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    </evidence>
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            <dbReference type="PubMed" id="15485849"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="19175416"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1056" mass="119431" checksum="09AB9E1AEC4CBE4C" modified="2017-01-18" version="1">MLYRVSGFYKRHTRNFTNIDYGYYIRNFIHHIASKIYPYAKVVLPNFRAAHYFYILTLVILGSILVYPVKTCAYIDVLFFTAGASTQAGLNTVNVNDLSLYQQIVLYLLATLATPIFIHGSLLFVRLYYFERHFDNIKERSLMDYRMRKSATLARLGSAPTMSSTRLNTFNNQVLGFQEREAEKGSSSSPQSSSSQTSQPVSTAYNDQGGNDIEHHSEPSDSDDDESGNGPVTFQEKIHFEEPQRPRSQRRHSRTDSGIKFSALPHPRRRKSIDPEDMYRSINMLQEHKKNQEAKSKGIQFLNIGSPVRRKSRSSNIEAFPEEDTNPSRGDEITPATNSVGTGNNDEDEDDILIIKPPIEIENSDEANPIFTKKKKLASQIQFKETPGKAKKWITTKTRKHYNPWTSKLKKTLSNSSKKGSLSVVPTDTEDDSEDEEYASIDSETSDISDNEHAADNAEGSDVDSVGSYEEDEDEDEHNSDDDDDGEGERRLGNGASLTKAQSHLVLPSKDETGGKKYTKRSNTLDTPQQNTSDGRKIRKKAPKRKTPRTQRNASFNQHSNVSIGDGSIENVDTNDSYQRLSRTMSGNYLSWTPTVGRNSTFIKLTDEQKEELGGIEYRAVKLLIKIIVVYYVGFNIIPGVMLSIWIYCMPHYKNLMISSSISPAWWAFFTSQSSFNDLGLTLTSNSMMSFNQNAFVQILCSFLIVIGNTGFPILLRFIIWVMFKTARPLSLYKESLGFLLDHPRRCFTLLFPSVPTWWLFFILVVLNGFDLVIFCILDLHDDTFKGVDMGYRVLNGLFQAFCTRTVGFSVMDLSQLHAATQVSYLIMMYISVLPIAISVRRTNVYEEQSLGVYAKENAEGVDESAPSNYVGSHLRNQLSYDLWYICLGLFIICIAEGKRLKEQDLRFSIFAVLFEIVSAYGTVGMSMGYPGVDCSLSGEFNVISKLVIIAMMIRGRHRGLPYTIDRAIMLPNAAMKRHDRLQEEHAINRHNTMERTTTLGRVATFGNGPIDGGNNLLTRAITNIEHRLRNRRDGRSESSTVSEDPRYVVRTVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU81</accession>
    <name>A0A1D8PU81_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">YHB4</name>
        <name evidence="18" type="ordered locus">CAALFM_CR10570CA</name>
        <name evidence="17" type="ordered locus">orf19.7637</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719397.1">
        <property type="nucleotide sequence ID" value="XM_714304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU81"/>
    <dbReference type="SMR" id="A0A1D8PU81"/>
    <dbReference type="FunCoup" id="A0A1D8PU81">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU81"/>
    <dbReference type="GeneID" id="3638999"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10570CA"/>
    <dbReference type="CGD" id="CAL0000174612">
        <property type="gene designation" value="YHB4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10570C_A"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU81"/>
    <dbReference type="OMA" id="EICAAWG"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000076">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="15">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="164"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000174612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW31705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="400" mass="47199" checksum="C054AA1D5B257A4C" modified="2017-01-18" version="1">MPIDINTKAKCYFDTRPLTKGERKIIKDSIPILEYLDIQFGEKFFKRLIKQFPQYKPYFNETHLKLLRQPRSFHHCLLEFARNIDDLRPMKDFIMRIASKHVARQVSPDQYRVFGQVLVEVMMDQFPKEFVDQEFVEAWTMAFRILANILINIEVREYQDKPWYGFKAFRVTRLQPECVGTKSFFITPVDGTPVPIPKRGQYLCMRWKFPGEKQERLREYTISEFPKNNEYRITVRYIPGGKVTTYIHEKLAVGDIVQVSPPCGDCYYRSSKRNMVMLAGGNGVVALAPMIEKGLAEGRKVKFLYSNRSTETRSFGQFFRDLKQKYGDQLEVVEYLSRRRVIDPIDKYYRRSLTVEDLDFIVPEDDVYLIGPRTYMKMIEDYLKGRGVNVTLDYFGPQEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>P0C8K9</accession>
    <name>COX1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c oxidase subunit 1</fullName>
            <ecNumber>7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome c oxidase polypeptide I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">COX1</name>
        <name evidence="5" type="ordered locus">CM_00210W</name>
        <name type="ORF">CaalfMp08</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="865" last="872">
            <title>Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.</title>
            <authorList>
                <person name="Anderson J.B."/>
                <person name="Wickens C."/>
                <person name="Khan M."/>
                <person name="Cowen L.E."/>
                <person name="Federspiel N."/>
                <person name="Jones T."/>
                <person name="Kohn L.M."/>
            </authorList>
            <dbReference type="PubMed" id="11208783"/>
            <dbReference type="DOI" id="10.1128/JB.183.3.865-872.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="2">Binds 2 heme A groups non-covalently per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="2">Binds a copper B center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9"/>
    <dbReference type="EMBL" id="AF285261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0C8K9"/>
    <dbReference type="SMR" id="P0C8K9"/>
    <dbReference type="FunCoup" id="P0C8K9">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P0C8K9"/>
    <dbReference type="EnsemblFungi" id="CM_00210W-T">
        <property type="protein sequence ID" value="CM_00210W-T-p1"/>
        <property type="gene ID" value="CM_00210W"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000187344">
        <property type="gene designation" value="COX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CM_00210W"/>
    <dbReference type="InParanoid" id="P0C8K9"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
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    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000356866" description="Cytochrome c oxidase subunit 1">
        <location>
            <begin position="1"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="414"/>
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            <name>Ca(2+)</name>
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            <name>Cu cation</name>
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            <name>Mg(2+)</name>
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            <begin position="243"/>
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    <evidence type="ECO:0000250" key="1">
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            <dbReference type="UniProtKB" id="P00401"/>
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    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000187344"/>
        </source>
    </evidence>
    <sequence length="531" mass="58744" checksum="EDB63911A328C6AA" modified="2008-12-16" version="1">MSYVTRWLFSTSHKDIGILYLIYGMVSAMVATGMSVIIRLELSGPGPMFLHGNNQVFNVLVTGHAIAMIFLFVMPILIGSFGNYFLPIMIGAVDMAFARLNNISFWCLPPALVCVIASVLIETGAGTGWTVYPPLSSISAHSGPSVDLAIFAIHLTSISSLLGAINFIVTTLNMRSIGIHMIDMPLFVWAIFFTAILLLLSLPVLTAGVTLLLMDRNFNTGFYEVAAGGDPILYEHLFYFFGHPEVYIIIIPGFGIISHVISTYTKKPIFGQIGMIYAIGSIGLLGFLVWSHHMYVVGLDIDSRAYFTSATMVIAIPTGIKIFSWLATLYGGELRLAVPMLFALGFLFLFTIGGLTGVMLSNASIDVAFHDTYYVVGHFHYVLSMGALFSLIAGYYYWGPAMFGLKYNKVLAEVHYWLLFVSVNIIFLPMHFLGLNGMPRRIPQYPDAFVGWNVVSSWGSIMSVISVLIGLYSVLVQLTNGENEREEIQVTPDYLESNNTRDVRDSDLELITSRPAQYHTFSELPILIQQI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LR2</accession>
    <accession>A0A1D8PNV7</accession>
    <accession>Q59LQ3</accession>
    <name>ATR_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MEC1</name>
        <name type="ordered locus">CAALFM_C504060CA</name>
        <name type="ORF">CaO19.1283</name>
        <name type="ORF">CaO19.8870</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes to nuclear DNA repair foci in response to DNA double strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710664.2">
        <property type="nucleotide sequence ID" value="XM_705572.2"/>
    </dbReference>
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    <dbReference type="SMR" id="Q59LR2"/>
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        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LR2"/>
    <dbReference type="EnsemblFungi" id="C5_04060C_A-T">
        <property type="protein sequence ID" value="C5_04060C_A-T-p1"/>
        <property type="gene ID" value="C5_04060C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647733"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504060CA"/>
    <dbReference type="CGD" id="CAL0000200852">
        <property type="gene designation" value="MEC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04060C_A"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_4_0_1"/>
    <dbReference type="InParanoid" id="Q59LR2"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="PRO" id="PR:Q59LR2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:DNA damage checkpoint signaling"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0042770">
        <property type="term" value="P:signal transduction in response to DNA damage"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000033">
        <property type="entry name" value="Serine/threonine-protein kinase MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000227709" description="Serine/threonine-protein kinase MEC1">
        <location>
            <begin position="1"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="3">
        <location>
            <begin position="1363"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="1993"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="3 4">
        <location>
            <begin position="2293"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="1999"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic loop" evidence="2">
        <location>
            <begin position="2174"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Activation loop" evidence="2">
        <location>
            <begin position="2194"/>
            <end position="2218"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="2325" mass="266545" checksum="7F0A008BFE0B9E28" modified="2017-03-15" version="2">MTSNQSISTTELLQFLTDIETNIDDHETDFRKLLLYLLRFTNEKLIVIAQEENKTPTELQLLSKLIDTIELVLSKKTPLLSTLLTIEDVNIIHTTGSGSLVYEVPLHEWCISFALSHIPNFVSHTAGLNQLKRLVFLIVNLVSTQLHSFKVIKSTRIHLLKTLDDNLNFCLQNLLSANTFLFKSKLTTAVNLFSIVHDYDISQKLSLNLNNYQLKFESCSRKIWFILNEISLVSELDNLNLLDCLKSVFILDQSSALVLNVSVGWNQIGFLLSCIVEYLQQDFRTLDSNTNNFEFVNLNRSISLSLLNVYIVCFDKDLLENFMSFSNIKGILSKLIYDDSIPSVIRKTLNIVQYTYQLMSNPDGDDIKLYSTSVYNDYVWTPFVDSELESLRARLLDLQGNHEDSRKEELLSFSIDETHKLAKSTNSLNYTDEKAWIRTVKKLIGIDKNVLEDETTLYTLVTALSHYPCILKGDYDYTINECTKCGFGPLTKNNYSSIDPNRFPLNYSTEATTLQDIIQQFLIPKLETQQDPLLCCNTLLLIFNFYASFSPMADMQDHNILDFLLRLLATNDNRDVRMLVARILPLYLIQSKDDKLLDETFKYIFQKVTSIDFSSQHRLHFGESTIRAVVELATVSTGERLCAIYFKLVDWLGEQNEQHSNYVYCGILNLASAKSLPPHKLLSPYLPSVAEIIIKKPQVFERIIKVSMVTKNYFLNRTKEYTVPRILEYYKDPTLLTQIANAAGLEVGKLLANCLPRILATYLTKESVNERYIMKVLSSVCPDYKMIHTEELFTRIGDITWYILLEIQMDEFGNIRNLANITRALECVCKNVSLRKNGSELTKNNSINDLIEDQVLLLVQKFSDVTHSSRGAKPYLELKNSFYAIEFLIKGHIDAITSALGQLSTCLQATLEEPNFHVLSLRCWNELIKKVPPSHLISLIDIIISIILQKFESFGSEAKSIAIEILRKIYEEIKDKYNRYSLYFLSLPFLSYMEDYQMVKEFRNMKSPSRAMIFSEFTRRLQTSNMYVVKHALFDLSNYFEKYQINCQKDLFKDPGLTPAITSLVRTILDTAAKFKNKDTTVSTACAKALAIIGALDSNKFQFKTVKSLIIISSDFEDIEENSTFLVDLIENHLLKIFWASNDPHKQLFAAYVMQSFLAVMGLDERVLNTKDNRVWNKFTDVAKSTLTPFLKSKYAAPKPKLDNLKFPFFKLGMKYETWLVDVTLFLLKRASIDNGKGNQKAKTRKLIFQSYAVLIQREHDIPLCEHLLRYVALSHVINEGVPEDLHKEFLHILKMDSKSTSPDRAEQLKLCYQTIFSVLDYFNQWVSNMRVVTSNSGSELTSSDIRHKMDAVAKFSSFPQDLLTTRSAECDAYERTIMYLENCYRDSQSEKSFKLSNLNGAATLQDMYAHIDDYDALNGTLKMFSTNNLNEKLTTFQYSDSWSLAHESFEALGSTKNSVSNNTKLLQSLNEHGLYNEVLSTLSARTDSNDLKSIPLDWSLMGLHAAVYKGDSKQLEKWLQVINSIGKPHDMETMINYELAKALSFLFQSRIDMFKGSMDKLYNIIGCSLVPSVSSNFTRNITLMNQLHAIYDVSLIVLSKDSEDTLDLRIGNVDQDFDTQRNILTLHNVANTVMKNPAMISKNLLRESSLARKYNRLDISTRSIVQAMSLEDDQANIEFAELQWAQGKQSEAIKCLFDILKDNKFHDDKSKAKVQLQYANWLDESNHLSAHQIITEYNKAFHLNMVDEKCNFDIGKYYNKLMESSNDESGEYEHLTVRNYIRAVSVGTTYIFEALPKVLTIWLDFADKSNKSNAAENRLKQIIDDLYNAIANVPNYSWYTVLTQILSRIVHEHEPSFKVLKRIVQNVTLEYPKHCVWYIFSHARSSDKVRKRRVRELLNQVCTQDGNDTLPKSTMAAGNLFAKLIKIAELKIPKTNRKRQMSLLQDFEVDLSEPIDDLVIPIQSNLQIQIPSHLNSKHKGFSRSSSISFDGFDDNVNIFFSLQMPRQLTVRGSDGNAYRLMVKSDDTRKDAKVVEFTTMVNRILSTSTEARKRGLQIANYSVVPLSDHFGIIEFVMNVQTMKGVISEQRKRQGIPINERKVFMHIDSLQKAKKKDSKQLDKLVAGFRAIMDRCPPVLHTWFVEQFSDPSAWYMARNAFTRSSAVMSMVGYIMGLGDRHCENILIFKNTGAVLHIDFDCLFEKGTTLPTPEIVPFRLTQNMVDAMGITGVDGIYRITCEVTGTLLRENEQILMNILETLIYDPLIDWRNHNPREDLSKVRKKIRGLINEDEGLPMNIHGQVDVLIQEATSLERLSQMYAGWAAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q59M00</accession>
    <accession>Q3MP79</accession>
    <name>Q59M00_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="11">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EPT1</name>
        <name evidence="16" type="ordered locus">CAALFM_C702690CA</name>
        <name evidence="15" type="ordered locus">orf19.11179</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="11"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710744.1">
        <property type="nucleotide sequence ID" value="XM_705652.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59M00"/>
    <dbReference type="FunCoup" id="Q59M00">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59M00"/>
    <dbReference type="GeneID" id="3647649"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702690CA"/>
    <dbReference type="CGD" id="CAL0000195072">
        <property type="gene designation" value="EPT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02690C_A"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035066_5_2_1"/>
    <dbReference type="InParanoid" id="Q59M00"/>
    <dbReference type="OMA" id="FITRQIC"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="PHI-base" id="PHI:8897"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000195072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW30624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="402" mass="45810" checksum="33936E160C0FC10D" modified="2005-04-26" version="1">MGLFIPTNKLQNLKLYKYSSEDHSIISKYILKKWWNFFVQIFPLSMAPNVVTLLGLFFIIGNLMTVFYYDPYLNETQPTWCYFFYAFGLFMYQTFDGCDGCHARRTGQSGPLGELFDHSIDAINTTLGTFVFASVLKMGYGGLLLLSQFASVCNFYTSTWEEYHTHTLFLSKFSGPVEGILMICIVYIITGIFGPDIWTIDLFELNLTSLGYGYYKVDTSIIYTIIGLTSLYFNIASAMFNVSKHYKKSSTNNSTNGDKDESTKDQISQAYRGLYPFFIYYGFVFLLLWIYPQILYDYGFPLVISIGCTIAFSVGRIILAHLTLQEFPFIQYPMFVPIGQLILSKILIDIYGYGTAKVLHAISWLGCGITLGIHGIFVAEVITEITTYLDIYALSIKHKKIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MB6</accession>
    <accession>A0A1D8PDG4</accession>
    <accession>Q59MA4</accession>
    <name>NAGS_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber>2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>N-acetylglutamate synthase</fullName>
            <shortName>AGS</shortName>
            <shortName>NAGS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ARG2</name>
        <name type="ordered locus">CAALFM_C105020CA</name>
        <name type="ORF">CaO19.56</name>
        <name type="ORF">CaO19.7717</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Nippon Ishinkin Gakkai Zasshi" volume="48" first="159" last="167">
            <title>Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium.</title>
            <authorList>
                <person name="Cho T."/>
                <person name="Aoyama T."/>
                <person name="Toyoda M."/>
                <person name="Nakayama H."/>
                <person name="Chibana H."/>
                <person name="Kaminishi H."/>
            </authorList>
            <dbReference type="PubMed" id="17975531"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Up-regulated in cells treated with farnesol and grown at high cell density in N-acetyl-D-glucosamine medium. Expression is regulated by the general amino acid control response transcription factor GCN4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710867.2">
        <property type="nucleotide sequence ID" value="XM_705775.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MB6"/>
    <dbReference type="FunCoup" id="Q59MB6">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MB6"/>
    <dbReference type="EnsemblFungi" id="C1_05020C_A-T">
        <property type="protein sequence ID" value="C1_05020C_A-T-p1"/>
        <property type="gene ID" value="C1_05020C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647533"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105020CA"/>
    <dbReference type="CGD" id="CAL0000184037">
        <property type="gene designation" value="ARG2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05020C_A"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013088_0_0_1"/>
    <dbReference type="InParanoid" id="Q59MB6"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="PRO" id="PR:Q59MB6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372556" description="Amino-acid acetyltransferase, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="403"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17975531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="580" mass="66683" checksum="387726E29CA0C75B" modified="2017-03-15" version="2" precursor="true">MSKLKTLNRQFISNLETHKVTTDAKRNLILSILKSTTTKREAKNYLTKYQNQFDFNDDLDFNKSIKIKNEQSSLTNRDSQRELFINRFLNQSNPFINVYDKEDVKLQKVPLRLAIFKIKFTKITIKQWKGIAETFKRLITLGISPIIMLDYDHLPSDSYKNNELYMINQGNKMLNYLGHPEEESDLKVTLLRSLFTSHKGVPTLDSLESILIPLYQGIIPIIQPIVYNADLSKQEFLASDKLLLGLSSALIEKRTTDLLSIEKIVMIDPIGGIPSIERHQTSHVFINLSQEYSDILSELFIGHIEPKYRDTHVDNLNTMNNVLSYINEKSGNDETTGIITTPEIMSINIDQLNPIIYNVLTDRAIISSSLPSTTNRTPHLSTTIIKKGVEVQIFDVDNYDKDLTMQNLFDDKLVNKEKLIDLLNDSFGKSLDVGPYLDRINKNIATVVIVGDYDGAAIITWEYSKGEKIAYLDKFAIAKKNQGLPGLADVIFKIILQSHPFELIWRSRKNNPVNKWYFERCCGCMSAPDSQWKIFYTGEVFDKKIDRFKRKLRHQNGVVDIDRKLQQYSEICEGITPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MK8</accession>
    <accession>Q9P825</accession>
    <name>Q59MK8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C503960WA</name>
        <name evidence="6" type="ordered locus">orf19.10727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710955.1">
        <property type="nucleotide sequence ID" value="XM_705863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MK8"/>
    <dbReference type="STRING" id="237561.Q59MK8"/>
    <dbReference type="GeneID" id="3647444"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503960WA"/>
    <dbReference type="CGD" id="CAL0000191323">
        <property type="gene designation" value="orf19.10727"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03960W_A"/>
    <dbReference type="eggNOG" id="ENOG502S7AZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162803_0_0_1"/>
    <dbReference type="InParanoid" id="Q59MK8"/>
    <dbReference type="OMA" id="DAGPYYP"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000191323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="129" mass="14139" checksum="D2D8E92377DCA26B" modified="2005-04-26" version="1">MSKDEYFGKPSGPPPNYNNQPQSQQPQQSYVPQSQPNYSQQTQDRGMFSGGGGGHGHYQQQQGYNAYGPPPPQGGYYQQQPGGGGGYYQQQQQQQPMYVQQQPRSGGNDSCLMGCLAALCVCCTLDMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NQ5</accession>
    <name>Q59NQ5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">GLR1</name>
        <name evidence="20" type="ordered locus">CAALFM_C501520CA</name>
        <name evidence="19" type="ordered locus">orf19.11623</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711351.1">
        <property type="nucleotide sequence ID" value="XM_706259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NQ5"/>
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    <dbReference type="MoonProt" id="Q59NQ5"/>
    <dbReference type="GeneID" id="3647061"/>
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        <property type="gene designation" value="GLR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01520C_A"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="Q59NQ5"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="BRENDA" id="1.8.1.7">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="38"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="402"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000194377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW29585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="516" mass="56483" checksum="155587BBD2379F9F" modified="2005-04-26" version="1">MFTNSIISKSTTRLTQLSRQLSTTTMAPTSTKNSIKHFDYLVIGGGSGGVASARRAAKYGAKVLLIESNFKKFGGTCVNVGCVPKKVMWYTADLAHKKHDLYAYGLDKEPDSIKYGDFDWAKLKHKRDAYVTRLNGIYENNLKREKVDYAYGFAKFINSEGEVEVTLSGDQELPFLDEGKTYKKGEKLVFSADKTLIATGGTAIVPPSVPGAELGTTSDGFFALEKQPKKVAIVGAGYIGVELSGVFSSLGSETHFFIRGDTVLRSFDEVIQNTVTDYYIDNLGINIHKQSTITKIEGSKDGKKVVHLKDGTSVEVDELIWTVGRKSLIDIGLDKVDVKINDKQQIVADEYQVTNNPKIFSLGDVVGKVELTPVAIAAGRRLSNRLFGGPEFAKDKLDYNNIPSVIFSHPEAGSIGLSTKEAIEKYGEENLKIYQSKFTAMYYAMMDDQKDKSPTVYKIICAGPEEKVVGLHIVGDSSAEILQGFGVAIKMGATKKDFDNCVAIHPTSAEELVTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P95</accession>
    <name>Q59P95_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C404270WA</name>
        <name evidence="11" type="ordered locus">orf19.8997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <comment type="function">
        <text evidence="7">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
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    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711985.1">
        <property type="nucleotide sequence ID" value="XM_706892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QN5"/>
    <dbReference type="SMR" id="Q59QN5"/>
    <dbReference type="STRING" id="237561.Q59QN5"/>
    <dbReference type="GeneID" id="3646399"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05160CA"/>
    <dbReference type="CGD" id="CAL0000175807">
        <property type="gene designation" value="orf19.8253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05160C_A"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674429_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QN5"/>
    <dbReference type="OMA" id="FNVIYWK"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="41"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000175807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="398" mass="46606" checksum="38E8FAA5D54863E8" modified="2005-04-26" version="1">MERIPLSVFEKFNNQELLSDVPEDRFISKSLQSPEIFSTPCEECTYFTKSNNNNILKFDDTTGLNTVLVSYTQQSKKRKQKKTNASSKGRPKIIGSDLTQGFSDFKPESLKDIYSLNDIFKSIQYLIQNKNFTPQDFKIVTARRHLQKLMTIPIHKQEVQFNVIYWKGMIFFAYDWKSESTTKVEDPYNKLIQYTGFKFEEVVSEGTRDSNFYTVVQHCVDNIPVIYTAEVDCSIDKETGLENYIELKTHTKLADDKISTINKLNKKLLSTFIQTKFIDCQHSIIGFRSTDLKIASIKKYTQRELAGEINSFPVILSDKCSINTKSIFQWYKLIMNWIISKEITDHNTPQIFRLSFKRDQELMNSYLKLEKILQEDDNDTIFNDLVPEWFQSFIMNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QN7</accession>
    <name>Q59QN7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">SDH2</name>
        <name evidence="22" type="ordered locus">CAALFM_CR05180CA</name>
        <name evidence="21" type="ordered locus">orf19.8251</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711983.1">
        <property type="nucleotide sequence ID" value="XM_706890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QN7"/>
    <dbReference type="SMR" id="Q59QN7"/>
    <dbReference type="FunCoup" id="Q59QN7">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59QN7"/>
    <dbReference type="GeneID" id="3646397"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05180CA"/>
    <dbReference type="CGD" id="CAL0000198657">
        <property type="gene designation" value="SDH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05180C_A"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_1"/>
    <dbReference type="InParanoid" id="Q59QN7"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0000198657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AOW31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="263" mass="30114" checksum="1F6342FD4E52EAEA" modified="2005-04-26" version="1">MFRSILHQQKAVQFSVRSLATAAAEKAPRLKKFQIYRWNPDTPEVQPKMQTYEVDLNKCGPMVLDALLKIKNEQDATLTLRRSCREGICGSCAMNIGGRNTLACLCRIDQDESKDLKVYPLPHMFVVRDLVPDLTHFYKQYKSIEPYLQRESNPADGRENLQSIEDRAKLDGLYECILCACCSTSCPSYWWNQQQYLGPAVLMQAYRWLIDSRDQATANRKAMLQNSMSLYRCHTIMNCARTCPKGLNPGKAIAEIKKQLAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RK4</accession>
    <name>Q59RK4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C600380CA</name>
        <name evidence="2" type="ordered locus">orf19.8791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712317.1">
        <property type="nucleotide sequence ID" value="XM_707224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RK4"/>
    <dbReference type="SMR" id="Q59RK4"/>
    <dbReference type="GeneID" id="3646085"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600380CA"/>
    <dbReference type="CGD" id="CAL0000192792">
        <property type="gene designation" value="orf19.8791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00380C_A"/>
    <dbReference type="HOGENOM" id="CLU_046448_0_0_1"/>
    <dbReference type="InParanoid" id="Q59RK4"/>
    <dbReference type="OMA" id="HSNHITY"/>
    <dbReference type="OrthoDB" id="4090326at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="331" mass="38087" checksum="70D738C86F730A0D" modified="2005-04-26" version="1">MLRSVSRDSFTTLIDQDDDNENDDLQSQQHENTQELTSDLISLISQETLINTSIQIMNRNISQFYKHYELPLISSYLHTGVSLYLSLQDLLDNKPPILTRTSSMMNFNNLLRRPFRNSSFLTIHKHDYMNNKFEFCHVDFKIHSNHITYYILKFPTLDKTVYLINNNSSKPTVDFEYKKTCFRITGVTGTTSVIGVSPEIKLYVMNPNSKNLLTYNTTVSNGKKLQINNSLSKLVNSQDQPRINEMLKNEKPVISIPMGRYLDQGDVKLKLDSNSATKSKSNIIKHGVIRLFDYQDEVGDTGNNVVSDDMLVLCCVLLVLREQEYRKFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SS4</accession>
    <name>Q59SS4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">PHB1</name>
        <name evidence="7" type="ordered locus">CAALFM_C303730CA</name>
        <name evidence="6" type="ordered locus">orf19.14206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly. Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease. Acts as a negative regulator of the m-AAA protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. The mitochondrial prohibitin complex interacts with the m-AAA protease, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. The mitochondrial prohibitin complex interacts with ATG8 and the interaction may support mitophagosome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712745.1">
        <property type="nucleotide sequence ID" value="XM_707652.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SS4"/>
    <dbReference type="SMR" id="Q59SS4"/>
    <dbReference type="FunCoup" id="Q59SS4">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SS4"/>
    <dbReference type="GeneID" id="3645641"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303730CA"/>
    <dbReference type="CGD" id="CAL0000180864">
        <property type="gene designation" value="PHB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03730C_A"/>
    <dbReference type="eggNOG" id="KOG3083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_0_1"/>
    <dbReference type="InParanoid" id="Q59SS4"/>
    <dbReference type="OMA" id="WNITYLL"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Band_7"/>
    </dbReference>
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        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
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        <property type="entry name" value="Prohibitin"/>
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    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
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    </dbReference>
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        <property type="entry name" value="PROHIBITIN 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Band 7/SPFH domain"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00057247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00063239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000180864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="283" mass="30839" checksum="01B83F33FCCCF232" modified="2005-04-26" version="1">MSQRIADFVSKIALPAGITIALAQSALYDVPGGKRAVIFDRLKGVKQGVIGEGTHFLVPWLQKAVIFDVRVEPRVITTTTGSKDLQNVSLTLRVLSRPEVRKLPTIYQTLGLDYGERVLPAIGNEILKSIVAQFDAAELITQREVVSARIRQELSRRAAEFNIELEDVSITHMTFGREFTKAVEKKQIAQQDAERSKYLVERAEQEKKAAIIRAEGEAESADVVSKALAKAGDGLLMIRRLEASKDIASTLANSPNITYLPNGGAGGSDSDGSKNSLLLNIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VY9</accession>
    <name>Q59VY9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">SHA3</name>
        <name evidence="7" type="ordered locus">CAALFM_C102120CA</name>
        <name evidence="6" type="ordered locus">orf19.11153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713763.1">
        <property type="nucleotide sequence ID" value="XM_708670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VY9"/>
    <dbReference type="FunCoup" id="Q59VY9">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q59VY9"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C102120CA"/>
    <dbReference type="CGD" id="CAL0000189265">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02120C_A"/>
    <dbReference type="eggNOG" id="KOG0583">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_4_1"/>
    <dbReference type="InParanoid" id="Q59VY9"/>
    <dbReference type="OMA" id="ICCNACR"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000189265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW25898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="595" mass="69327" checksum="A823548DCB475876" modified="2005-04-26" version="1">MTLDILPIFDTHTKHHYVSSGATSTTDNTTTFTSATIYQPQTTTSSNKPNVNCLLNGYMLNHELRFIRKIGAGTYGLIYLVENIYTKQQFAAKMVLEQPLLKQKQQQQQSHHGHKGESSMNKQIISQEFYQYFLNNSMPQPRNLDLNYLRDNGHDCPFLTEISLHLKVHQHPNIATIHQVLNIEDFAIIILMDHFEQGDLFTNIIDRQIFTNNSHRKVPRTDFETQLLMKNAMLQLIEAIEYCHENNIYHCDLKPENIMVRYNPYYVRPTINNNNNNGEDDLCYANSIIDYNELHLVLIDFGLAMDSATICCNSCRGSSFYMAPERTTNYNTHRLINQLIDMNQYESIEINGTTVTKSNCKYLPTLAGDIWSLGVLFINITCSRNPWPIASFDNNQNNEVFKNYMLNNNKAVLSKILPISSQFNRLLDRIFKLNPNDRIDLPTLYKEVIRCDFFKDDHYYYAQHQHHHNHNQINNAYNHYQKQPNQARPTANQQLYTPPETTTYNSYASDMEEDEISDDEFYSDEEDEDIEEYEEEEEEYFGNEQQQQQQVTTVNGNFGQVKGTCYYDTKTKTTTYIKPPAAYTLETPSQSVEYC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-06-26" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WH0</accession>
    <accession>A0A1D8PEY3</accession>
    <name>ADA2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ADA2</name>
        <name type="ordered locus">CAALFM_C110860CA</name>
        <name type="ORF">CaO19.2331</name>
        <name type="ORF">CaO19.9867</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="PLoS Pathog." volume="2" first="E21" last="E21">
            <title>Control of the C. albicans cell wall damage response by transcriptional regulator Cas5.</title>
            <authorList>
                <person name="Bruno V.M."/>
                <person name="Kalachikov S."/>
                <person name="Subaran R."/>
                <person name="Nobile C.J."/>
                <person name="Kyratsous C."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="16552442"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.0020021"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1750" last="1758">
            <title>Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model.</title>
            <authorList>
                <person name="Pukkila-Worley R."/>
                <person name="Peleg A.Y."/>
                <person name="Tampakakis E."/>
                <person name="Mylonakis E."/>
            </authorList>
            <dbReference type="PubMed" id="19666778"/>
            <dbReference type="DOI" id="10.1128/EC.00163-09"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="2389" last="2400">
            <title>Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans.</title>
            <authorList>
                <person name="Sellam A."/>
                <person name="Askew C."/>
                <person name="Epp E."/>
                <person name="Lavoie H."/>
                <person name="Whiteway M."/>
                <person name="Nantel A."/>
            </authorList>
            <dbReference type="PubMed" id="19279142"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-11-1093"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 8 9">Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B. Required for expression of many CAS5-dependent genes. Plays a key role in cell wall integrity, cell adhesion, hyphal development and pathogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of SAGA complex, SALSA complex, and ADA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AOW26713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_708843.2"/>
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        <property type="interactions" value="1"/>
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        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WH0"/>
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        <property type="protein sequence ID" value="C1_10860C_A-T-p1"/>
        <property type="gene ID" value="C1_10860C_A"/>
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    <dbReference type="GeneID" id="3644450"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110860CA"/>
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        <property type="gene designation" value="ADA2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_018273_3_0_1"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="GOC"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="C:SLIK (SAGA-like) complex"/>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="term" value="F:phosphatidylserine binding"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="term" value="P:development of symbiont in host"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:filamentous growth"/>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
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    </dbReference>
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        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
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        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
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    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcriptional adapter 2"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="ADA2-like_ZZ"/>
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        <property type="entry name" value="Ada2/TADA2"/>
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        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="SANT_dom"/>
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        <property type="entry name" value="SWIRM"/>
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        <property type="entry name" value="TADA2A_B-like_dom"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
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        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
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        <property type="entry name" value="TADA2A-like_3rd"/>
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        <property type="entry name" value="ZZ"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="ZF_ZZ_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000422794" description="Transcriptional adapter 2">
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            <begin position="1"/>
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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    <feature type="binding site" evidence="2">
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            <position position="10"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="445" mass="51110" checksum="906898F5F06FF2F2" modified="2017-03-15" version="2">MDSRTKLFHCDVCSSDCTNRIRIQCAICTDYDLCVPCFAAGLTTGDHKPWHDYQIIEQNTYPIFDRDWGADEELLLIQGCETSGLGNWADIADHIGNRSKEEVAEHYFKIYLESKDYPLPEMNKDFTDVSPLQFLEERKERLEKRKNIPLPPPRGKPVASVPLCHEIQGYMPGRLEFDHEAENEAEIPIKDMVFDPEDSANDIDLKLTILDIYNSRLTTRAERKRVMILNHLLDYRKNIGSDKRKSKEEKDLLKKINAFIRILTPEDFESFSRDLLTELKCRMKIQQLQTWRRNGITTLEDGAKFEKDKVIRAAHYQRMGNGTGSGRHSQTPGLTNGNSFNGNGHRNKFSPQPEFRSKSTTARAPLDISHAADFELLSAEEKQLCATLRILPKPYLAIKNQLMREAVKNNGVLKKKDARQALKIDVNKASKIYEFFVHMGWCSQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YT1</accession>
    <accession>A0A1D8PKF5</accession>
    <name>QDR2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MFS antiporter QDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">QDR2</name>
        <name type="ordered locus">CAALFM_C305570WA</name>
        <name type="ORF">CaO19.6992</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="BMC Genomics" volume="9" first="579" last="579">
            <title>MFS transportome of the human pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Gaur M."/>
                <person name="Puri N."/>
                <person name="Manoharlal R."/>
                <person name="Rai V."/>
                <person name="Mukhopadhayay G."/>
                <person name="Choudhury D."/>
                <person name="Prasad R."/>
            </authorList>
            <dbReference type="PubMed" id="19055746"/>
            <dbReference type="DOI" id="10.1186/1471-2164-9-579"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Biochem. J." volume="460" first="223" last="235">
            <title>Novel role of a family of major facilitator transporters in biofilm development and virulence of Candida albicans.</title>
            <authorList>
                <person name="Shah A.H."/>
                <person name="Singh A."/>
                <person name="Dhamgaye S."/>
                <person name="Chauhan N."/>
                <person name="Vandeputte P."/>
                <person name="Suneetha K.J."/>
                <person name="Kaur R."/>
                <person name="Mukherjee P.K."/>
                <person name="Chandra J."/>
                <person name="Ghannoum M.A."/>
                <person name="Sanglard D."/>
                <person name="Goswami S.K."/>
                <person name="Prasad R."/>
            </authorList>
            <dbReference type="PubMed" id="24621232"/>
            <dbReference type="DOI" id="10.1042/BJ20140010"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="3 4">Preferentially localizes to membrane rafts.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Leads to defects in biofilm architecture and attenuated virulence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_709605.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0000314"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000431600" description="MFS antiporter QDR2">
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            <begin position="1"/>
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        </location>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="42"/>
            <end position="62"/>
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    </feature>
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            <begin position="130"/>
            <end position="132"/>
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            <begin position="133"/>
            <end position="155"/>
        </location>
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        </location>
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            <end position="190"/>
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    <feature type="topological domain" description="Cytoplasmic" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    <sequence length="504" mass="54897" checksum="626CC2DD444FF496" modified="2005-04-26" version="1">MLSTTQSVTEPTEVTSKKVEDIEKENDEETPYSIFTSYDRLVLIVILSLIGFWSTISSPIYFPALPTLTSYFHTSSSIMNISVVAYLIFQGIAPTISSNLADTFGRRPVILASIIVFCASCVAISQTNVYWLLAVLRCIQAAGIAAVISISSGVAGDVCTRANRGSMVGAVAGLQLVGNGIGGLVGAALISSFNSWRSIFIFLTIGGGVTFILAIFILPETSRKLVGNGSVVPKNILNKSPYIYLPHFKKRMNNDITTIVPATRFDLLGPLKIFFQKNVFCTLLPVGIHFAAWTMVLTSLSTELESRYHYSVMHVGLIYLPQGIACIAGSLVVGKSLDWYYRYRKTIYDQEVECLPLDERPQFNIVATRLTLSVVPALLMIIGLVIFGWCIQYKRHIISIIISTILVSFSASVFIAICTTMLVDLYPNNGSGSTSCLNLMRCWLAALGAGVLDSMINAMNVGGTYTVVAGFCILFDLALIYVLHNAKKKFSNSGPTTTKSPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Z24</accession>
    <name>Q59Z24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C207200WA</name>
        <name evidence="15" type="ordered locus">orf19.9816</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
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        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
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    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
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        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
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        <property type="entry name" value="Znf_TFIIS"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_ribbon_RPB9"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000191376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="112" mass="12876" checksum="292DDDF39F5FFEF0" modified="2005-04-26" version="1">MASFRFCAECNNMLYPKEDKEGQRLLYACRNCGYTELAENPKVYRHELMTNIGATAGVVEDIGNDPTLPRSDKECPDCGHHECVFFQSQQRRKDTSMILFFVCLNCKHVFQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0W7</accession>
    <accession>A0A1D8PMN2</accession>
    <name>RUVB1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>RuvB-like helicase 1</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RVB1</name>
        <name type="ordered locus">CAALFM_C406800WA</name>
        <name type="ORF">CaO19.10641</name>
        <name type="ORF">CaO19.3129</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715438.1">
        <property type="nucleotide sequence ID" value="XM_710345.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0W7"/>
    <dbReference type="SMR" id="Q5A0W7"/>
    <dbReference type="BioGRID" id="1225958">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A0W7">
        <property type="interactions" value="1607"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0W7"/>
    <dbReference type="EnsemblFungi" id="C4_06800W_A-T">
        <property type="protein sequence ID" value="C4_06800W_A-T-p1"/>
        <property type="gene ID" value="C4_06800W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642917"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406800WA"/>
    <dbReference type="CGD" id="CAL0000181596">
        <property type="gene designation" value="RVB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06800W_A"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A0W7"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="PRO" id="PR:Q5A0W7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000165650" description="RuvB-like helicase 1">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="458" mass="49990" checksum="CBDA78C439989BA9" modified="2005-04-26" version="1">MVQITEVKENQSSRESRTAAHTHIKGLGLNEQGIAKPIEGGFVGQNEAREACGIIVDLIKSKKMSGKAVLIAGPPATGKTALALAISQELGPKVPFCPIVGSELYSAEVKKTSALMENFRRAIGLRIKETKEVYEGEVIELTPEEAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPVIYESIQKERVTIGDVIYIEANTGAVKRVGRSDAYATEFDLEAEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVLSMMGQLLKPKKTEITDKLRTEVNKVVSKYIEQGVAELVPGVLFIDEVNMLDMEIFTYLNRALESSIAPIVVLASNRGLTTVRGSDDGVKAPHGCPPDLIDRLLIVRTLPYNQEEIKTIIGKRASLEGLTLTDDALEKLSKQGLTTSLRYAVQLLTPAGVLSTTAGRSEITVQDIEECEFLFLDSRRSTKVLQETKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A359</accession>
    <name>Q5A359_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">GSH2</name>
        <name evidence="15" type="ordered locus">CAALFM_CR08370WA</name>
        <name evidence="14" type="ordered locus">orf19.13762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716243.1">
        <property type="nucleotide sequence ID" value="XM_711150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A359"/>
    <dbReference type="SMR" id="Q5A359"/>
    <dbReference type="FunCoup" id="Q5A359">
        <property type="interactions" value="940"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A359"/>
    <dbReference type="GeneID" id="3642083"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08370WA"/>
    <dbReference type="CGD" id="CAL0000176594">
        <property type="gene designation" value="GSH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08370W_A"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="InParanoid" id="Q5A359"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
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            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <end position="384"/>
        </location>
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            <name>ATP</name>
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        </ligand>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        </location>
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            <name>ATP</name>
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        </ligand>
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            <end position="411"/>
        </location>
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        </ligand>
    </feature>
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        <ligand>
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        </location>
        <ligand>
            <name>substrate</name>
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            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <begin position="472"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000176594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW31518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="485" mass="55197" checksum="6259C2694D250891" modified="2005-04-26" version="1">MSIKPFPELSHDQEKELVTNLSQWSLGNGLVMYPPNFEGFQANVAPITLFPTPIPKESFHRAVKVQKLFNELYINVITKDVKWFSSILEDLSKHDSEFTGRLFEVYQKSSKIQPLSLGLFRSDYMIHQDTNEIKQIEFNTVSVSFGGLSSKIGQLHQYLNGTGQYDSKYNYKYYDDEDEIPVSTSASDLAQGLADGNFYYHNGEPKTSSVVLFIVQPNERNSFDQRHVEYALFKEHGIKSVRFTLEEVEEHVTVNQNRLYIKSTMDEVSVVYYRSGYAPSDYDVNPEKTWAARLLLEDTLAIKCPSVLTQLSGTKKVQQLLTKKEVISKFLSNSSDQELNEVLSTFVAIYSLDDSNEGDTGRKLAFEEPEKFVLKPQREGGGNNVYKENIPSFLEKLDKQEWGAYILMELINPPTHKNKIIRNNEVFHEDIISELGVFGTTVFNEKTGEILTNKNAGWLLRSKFSNSNEGGVAAGFGCVDNIYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A390</accession>
    <name>Q5A390_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR08130WA</name>
        <name evidence="1" type="ordered locus">orf19.13731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716214.1">
        <property type="nucleotide sequence ID" value="XM_711121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A390"/>
    <dbReference type="SMR" id="Q5A390"/>
    <dbReference type="FunCoup" id="Q5A390">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A390"/>
    <dbReference type="GeneID" id="3642070"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08130WA"/>
    <dbReference type="CGD" id="CAL0000187289">
        <property type="gene designation" value="orf19.13731"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08130W_A"/>
    <dbReference type="eggNOG" id="KOG4614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047290_2_0_1"/>
    <dbReference type="InParanoid" id="Q5A390"/>
    <dbReference type="OMA" id="SGMYDVY"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000187289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="44246" checksum="1D284FC654B422DA" modified="2005-04-26" version="1">MFVYWINNLCEIIQCICWRRRRQGRTFFPSYFFFSLSLFFQSHCSSVKGWLFCAEPCGSVNARHRVIFGETKRILKNRGLNSTTDWLDDKMQSVFIRTFATSRIEFQRYQPRFVNTIKETVKSAQEKSYSITRPLGLSKPVLLNHKLSDTYSLSNIYEELFGQKSKERRQKQLDYDLKHSPIYEVKSFENTKGKIFTPPVSYFRQDKSLYFPDFIAKTLAGNQRSLYDSLDNRLSIVKLFSSVAGEQCTRSYFKVENKDYYSQDYDTFVEEYPHTQILDVNMPQSWIKGFVTNLSTGNLRKTLKPASRYENYFILPGHIMSAEIREQLYCDNQCSGYIYIVDSMGKIRWATSGYATPEDLKLMWKVVKGVQREMTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A519</accession>
    <accession>A0A1D8PMZ7</accession>
    <name>CG121_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CGI121</name>
        <name type="ordered locus">CAALFM_C500620WA</name>
        <name type="ORF">CaO19.8542</name>
        <name type="ORF">CaO19.927</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716766.1">
        <property type="nucleotide sequence ID" value="XM_711673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A519"/>
    <dbReference type="SMR" id="Q5A519"/>
    <dbReference type="FunCoup" id="Q5A519">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A519"/>
    <dbReference type="EnsemblFungi" id="C5_00620W_A-T">
        <property type="protein sequence ID" value="C5_00620W_A-T-p1"/>
        <property type="gene ID" value="C5_00620W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641584"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500620WA"/>
    <dbReference type="CGD" id="CAL0000182468">
        <property type="gene designation" value="orf19.8542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00620W_A"/>
    <dbReference type="eggNOG" id="KOG4066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065847_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A519"/>
    <dbReference type="OMA" id="IVCRMST"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="PRO" id="PR:Q5A519"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0779">Telomere</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000279208" description="EKC/KEOPS complex subunit CGI121">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="203" mass="23374" checksum="CC11DCD6A8163E1D" modified="2005-04-26" version="1">MTSEVIKFPQFPEFTIHISLFINVSSENITTIKSNLISATDNDHNKYDYCFLNTKYIISKEHLFQSIYKSLLNYTSKLGLSTRNLKSEIIYNLSPINNVGDALKRFGISEDCPNCIVIKIINNNNKENSEETKISEKVTTDLKEIIDGELIELNDQYIFENFIDLAKFRKLYKLNDVVDLNKEDNLQGRLTRLAIGACILRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6L6</accession>
    <name>Q5A6L6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">GPI2</name>
        <name evidence="11" type="ordered locus">CAALFM_CR04470WA</name>
        <name evidence="10" type="ordered locus">orf19.8171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717401.1">
        <property type="nucleotide sequence ID" value="XM_712308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6L6"/>
    <dbReference type="FunCoup" id="Q5A6L6">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6L6"/>
    <dbReference type="GeneID" id="3641011"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04470WA"/>
    <dbReference type="CGD" id="CAL0000197896">
        <property type="gene designation" value="GPI2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04470W_A"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024002_2_1_1"/>
    <dbReference type="InParanoid" id="Q5A6L6"/>
    <dbReference type="OMA" id="STSYHAF"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="BRENDA" id="2.4.1.198">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="PHI-base" id="PHI:8195"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
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            <end position="221"/>
        </location>
    </feature>
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            <end position="252"/>
        </location>
    </feature>
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        <location>
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            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000197896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="304" mass="34923" checksum="D70EE099BE07C734" modified="2005-04-26" version="1">MEEIHISSSILQDSDSAPPNHFQHAQQQEQPSWKKLLYLQQPFPDNYTDQSFLSQLKRNTTVAKYSYKNLVQAFSFIVFYISCILLVILMFIGIYEKQWDPIIPTLISTGISLVGFFSLKNLSMNMRSLMVITFILLIVSPILKSLTKSTSSDSIWAISCVLCLANSIFHDYSMKVSYRPIVSTNISLSNAIVLASRLSTTLDVFLFVLFAIEVNILLPLFDAKIRLSGLETIHWPIAFLTFNLTSYLMYILLNYKFLVYWILSVFVMVVIMPIYFLSLQRYKNEIQGPWDVAKPKLMKSSIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7A9</accession>
    <name>Q5A7A9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C107820WA</name>
        <name evidence="13" type="ordered locus">orf19.12519</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_712497.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="InParanoid" id="Q5A7A9"/>
    <dbReference type="OMA" id="TRMQSKY"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
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        <property type="entry name" value="TXTP-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="286"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000180534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW26423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="386" mass="43378" checksum="5E652870BFDD1E02" modified="2005-04-26" version="1">MPTNKPETTPGGENLLAALISCTTAAAFSATCTYPFDFIKTQQQLNNEKVMKKWNIPGNYPNSLAQLYKGGSALVLGSIVKNGTRIIAYNWSTQFMSIDSHNGNNNKTTAPRIVIAGVMSGFIETLWLIPFENVKITMIQNQTLANELKRCKNLGYDITGKVTHSPSTHHKSTKPIYLRQYVSPHAYLSSDVIDQYIKQKVRFGGVPIKDKALESLKFHYNKHPSLTLFGTVKEMYELKGLRAFTAGTFITFTRQIGISWVWLATYNATRQLIDPHNTNNEWFGHKHTMIQSVGLHFLSSMAVIMVTQPLDVIKTHLQSKNGNSLYRDSLSTAYKLFLQQGPWALFKGAFPRFLKVLISGGLTATVYEYVERLVDVAGHQKIFSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7K7</accession>
    <name>Q5A7K7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C300130CA</name>
        <name evidence="3" type="ordered locus">orf19.12914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717830.1">
        <property type="nucleotide sequence ID" value="XM_712737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7K7"/>
    <dbReference type="SMR" id="Q5A7K7"/>
    <dbReference type="FunCoup" id="Q5A7K7">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A7K7"/>
    <dbReference type="GeneID" id="3640593"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300130CA"/>
    <dbReference type="CGD" id="CAL0000181297">
        <property type="gene designation" value="orf19.12914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00130C_A"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009985_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A7K7"/>
    <dbReference type="OMA" id="YFTAPTW"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </evidence>
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        <source>
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    <sequence length="525" mass="59442" checksum="1C038F2E1260690B" modified="2005-04-26" version="1">MKGQSKNGHRRSNSRFANDDKRLVYLTSKAMGKKCIATITDGSRYQGLLVGSDLSPLSVVLLKPQLVGSSLLNEKNNLDKLPENLIIQAKDLIDLEVDVDLSEPVKPPHEFKTDADISGKMQIKERELERWVPDDEVELTLEDDGSEWDQFKVNQEKFGVESSYDEHLYTTRIDTSAPDYHERVAKAERIAKEIEQQATTDRHILEERGVVVDDSGVDEEDKYSGVDRRGDELMAALRNASISKPAQQGTTTHHHHDPAIVSSSKQAKPESIPPKPPVPNESFRLNAQSEINSLREFSANFKIPHKMPQDLLPILAKDKMKQDEILKKQQDHTKKEPKTYKLNPKAAVFTPSSKHATISSPKKSPRPYSNGNVKKHYQISAADFFGVNKVPTKDGQTTKIKEFKCGFNMFVTTRRKHKEYEKSFQTPPTWESTVDVAHDKLFTARPIVAPVAPPIYANKFPMSPQAAAMMQQQQQQQFAMMFPPQMPVFYGDPTFYPPQGFVPPPQFGNPMMMGNPYGRRYTKKH</sequence>
</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000177328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="235" mass="26997" checksum="41CF78D54E2A3776" modified="2005-04-26" version="1">MFMDNQQQTLVTPRAHTYYPKMHTTPKQHTRSASSSQRTNLAPPASNRSYSQNHLLPNQPTTREPQENSMLTSDNKICQWYCCSCGQSYGSVLYKDDYREVRPNGQPPQKRARSLDSSNYILDSLKYYSQVVYRDHKHVISNASFSAGSSVNSNADTNYFDCKTATTDTEESHSPTITPNTPMLSPLHLNLNHNSFIDYREKIILNIPTRFTCHRCNHMMCPYCLKLRLKDLDTS</sequence>
</entry>
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    <accession>Q5A878</accession>
    <name>Q5A878_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-processing protein PRP40</fullName>
        </recommendedName>
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        <name evidence="4" type="ordered locus">CAALFM_CR01050CA</name>
        <name evidence="3" type="ordered locus">orf19.10760</name>
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    <organism evidence="4 5">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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        </source>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="FunCoup" id="Q5A878">
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0152">
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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            <begin position="48"/>
            <end position="81"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="602" mass="71034" checksum="51F8E0CBCCB54DD5" modified="2005-04-26" version="1">MSSDWEELRTETGEVYYYNYKTNETSWTFPETEETLPVSEKQETITTSTTTGKWEEYTTDDGKKYYYNAITGETTWEKPNEIIEEELSNEKLAEKTELSELDKTLKSKPVELTGPTSKTDNEAKQSFLKLLSDNKVNSTWSFQAVMENLVDKPEYWSVKDPVTRKQLYEEYLVSKFQSELSNKSLLLENFKRNFNEELRKLEAKNLVTYNTRWITIKKLWIDQDNPIFKHSMMSDSELAAIFYEYTDKLREQHEKLLQTKKNQALIELSTYLRQVNSSLVEKSQTWESLYENLINDSRFQSNKNFQNLTKLNILQLYENEIFPRRIDDIKSQITVISKINYRNDRKARESYKKLLGELEIDADTEFKDIIDKIENNDAFIEICGRNGSSALELFWDIVDEKKQILKVKKNLVDSVISTMKNGNTYDEKMWESLETFSNALKSTRDERLANLDLTLGDGGKGKEITMIYTSLKEEFELKKQQEREKYLKKMDEDIAKLARWIYDNDRNLGENFLRMEGTRFVISNRVNYEDEYEKLSKFDQFKPLKQYEIELSTTKITKKIIEEFVSEYNKHASRKRQSSITSETNKTGDKRLKTGVATVLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A886</accession>
    <name>Q5A886_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TAF10</name>
        <name evidence="9" type="ordered locus">CAALFM_CR01120CA</name>
        <name evidence="8" type="ordered locus">orf19.10752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717933.1">
        <property type="nucleotide sequence ID" value="XM_712840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A886"/>
    <dbReference type="SMR" id="Q5A886"/>
    <dbReference type="FunCoup" id="Q5A886">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A886"/>
    <dbReference type="GeneID" id="3640434"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01120CA"/>
    <dbReference type="CGD" id="CAL0000185379">
        <property type="gene designation" value="TAF10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01120C_A"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A886"/>
    <dbReference type="OMA" id="NNPMGTL"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000185379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="244" mass="26818" checksum="DDF2C3ED8AA52858" modified="2005-04-26" version="1">MSEPINKPEDEEMDVEFNDVDDQIVPDELPEQAQKQDDQQPQQSQSQTAETKIDTGDSAKPQNDATSSTAHPTGTANGTPPASVIPELPDLTRKDKSLKEVLDLMDGDFAPIIPDAVTDYYLAKNGFETSDIKIKRLLALATQKFISDIAQDAYEYSRIRSASAVYNSSNPQVRAKLLLQGQQYANQQTLTGNANNNGEGDQQQSSQSHSNAGNQQGKIVLTMEDLSNALSEYGMNTSRPDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8I4</accession>
    <name>Q5A8I4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SKI complex subunit WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">SKI8</name>
        <name evidence="5" type="ordered locus">CAALFM_C603890CA</name>
        <name evidence="4" type="ordered locus">orf19.13187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718099.1">
        <property type="nucleotide sequence ID" value="XM_713006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8I4"/>
    <dbReference type="SMR" id="Q5A8I4"/>
    <dbReference type="FunCoup" id="Q5A8I4">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A8I4"/>
    <dbReference type="GeneID" id="3640294"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603890CA"/>
    <dbReference type="CGD" id="CAL0000201104">
        <property type="gene designation" value="SKI8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03890C_A"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065016_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A8I4"/>
    <dbReference type="OMA" id="CVCLDRS"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065004">
        <property type="term" value="P:protein-DNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14 15" key="2">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_713749.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006375"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000199020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW26313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="345" mass="38737" checksum="A2F6130FBD8283FA" modified="2005-04-26" version="1">MSLSPIEKAASGALASAIANTLVYPLDLSKVLIQTQVKKNKPKSGSNGIPTPPSESDLEDSVYKQKVDEDNGLKYKNTIDVLTQIYKKKGILGWYHGLFSTVVGTAAQNFSYFYWYTIVKRVYANLYKHIPNHKPGTFTELFLGALAAAISQCFTMPIGVITTQQQTDKSHKNLFQLIQDILDQDGISGLWRGLRVSMVLCINPSITYGSYERLKQVLYGDKQFLKPLESFSLGVLAKSLATIATQPLIVSKAMIQKKSSPKKNNKATDKNTEEDDEEDIKFDHFTDALAYLWRTEKFRGLYKGIAPQLLKGVFVQGLLFTFKDQLDILFLFLLSLIKNRSVLKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABC6</accession>
    <accession>A0A1D8PC95</accession>
    <name>MOB2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>CBK1 kinase activator protein MOB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MOB2</name>
        <name type="ordered locus">CAALFM_C100620WA</name>
        <name type="ORF">CaO19.13465</name>
        <name type="ORF">CaO19.6044</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="5456" last="5477">
            <title>Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans.</title>
            <authorList>
                <person name="Song Y."/>
                <person name="Cheon S.A."/>
                <person name="Lee K.E."/>
                <person name="Lee S.Y."/>
                <person name="Lee B.K."/>
                <person name="Oh D.B."/>
                <person name="Kang H.A."/>
                <person name="Kim J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="18843050"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-03-0272"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH CBK1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mol. Biol. Cell" volume="22" first="2458" last="2469">
            <title>CDK-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans.</title>
            <authorList>
                <person name="Gutierrez-Escribano P."/>
                <person name="Gonzalez-Novo A."/>
                <person name="Suarez M.B."/>
                <person name="Li C.R."/>
                <person name="Wang Y."/>
                <person name="de Aldana C.R."/>
                <person name="Correa-Bordes J."/>
            </authorList>
            <dbReference type="PubMed" id="21593210"/>
            <dbReference type="DOI" id="10.1091/mbc.E11-03-0205"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>PHOSPHORYLATION AT SER-44; SER-51; SER-67 AND SER-97</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002683" last="E1002683">
            <title>The NDR/LATS kinase Cbk1 controls the activity of the transcriptional regulator Bcr1 during biofilm formation in Candida albicans.</title>
            <authorList>
                <person name="Gutierrez-Escribano P."/>
                <person name="Zeidler U."/>
                <person name="Suarez M.B."/>
                <person name="Bachellier-Bassi S."/>
                <person name="Clemente-Blanco A."/>
                <person name="Bonhomme J."/>
                <person name="Vazquez de Aldana C.R."/>
                <person name="d'Enfert C."/>
                <person name="Correa-Bordes J."/>
            </authorList>
            <dbReference type="PubMed" id="22589718"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002683"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. The RAM network is critically required for hyphal growth as well as normal vegetative growth, and for polarization of lipid rafts and the actin cytoskeleton. It play an essential role in biofilm formation. The RAM network also plays a role in serum- and antifungal azoles-induced activation of ergosterol biosynthesis genes, especially those involved in the late steps of ergosterol biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">localizes to sites of polarized growth in both yeast and hyphal cells.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Phosphorylated by CDC28 at Ser-44, Ser-51, Ser-67, and Ser-97. Phosphorylation occurs during bud emergence and is maintained until the G2/M transition. Dephosphorylated at the end of mitosis. Phosphorylation is required for the maintenance of polarisome components in hyphae.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Leads to hypersensitivity to cell-wall- or membrane-perturbing agents, cell-separation defects, a multinucleate phenotype, and loss of cell polarity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MOB1/phocein family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW25760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719006.1">
        <property type="nucleotide sequence ID" value="XM_713913.1"/>
    </dbReference>
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        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABC6"/>
    <dbReference type="iPTMnet" id="Q5ABC6"/>
    <dbReference type="EnsemblFungi" id="C1_00620W_A-T">
        <property type="protein sequence ID" value="C1_00620W_A-T-p1"/>
        <property type="gene ID" value="C1_00620W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639381"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100620WA"/>
    <dbReference type="CGD" id="CAL0000186024">
        <property type="gene designation" value="MOB2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00620W_A"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ABC6"/>
    <dbReference type="OMA" id="CNHSSER"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="PRO" id="PR:Q5ABC6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031579">
        <property type="term" value="P:membrane raft organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090033">
        <property type="term" value="P:positive regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900233">
        <property type="term" value="P:positive regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062200">
        <property type="term" value="P:RAM/MOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000004">
        <property type="entry name" value="CBK1 kinase activator protein MOB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000424372" description="CBK1 kinase activator protein MOB2">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDC28" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDC28" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDC28" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CDC28" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18843050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21593210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22589718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="313" mass="35384" checksum="8554555198B9AAA8" modified="2005-04-26" version="1">MSFLNTIRGLGRGSKKNKKDLEPSNNAIYSHSNLSGNGLRRTQSPTKFSPSKLSSKGAQGSAAYTSSPTKRSRTGQSLQHQDSQSSLQYQQQSGSVSPSKRSSIQTTKSTTVNADPPLFLCEPYVKTALVKGSFKTIVQLPKYVDYCEWLALNIFELFNHLNRFYGVIQEYATPEAYPTMNAGPNTNYLWVNSSGQAVNLPACQYIEYVITWVTNKLNDQSVFPTKNGGAFPPNFIKDCKNISRQMFRIFAHIYHNHFDKIIHLSLEAHWNSFFAHFISFVKEFNLIDRTEMEPLLPLIENFEQQGKITQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD24</accession>
    <name>Q5AD24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Iron-sulfur protein IND1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C200810CA</name>
        <name evidence="7" type="ordered locus">orf19.9591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719492.1">
        <property type="nucleotide sequence ID" value="XM_714399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD24"/>
    <dbReference type="SMR" id="Q5AD24"/>
    <dbReference type="STRING" id="237561.Q5AD24"/>
    <dbReference type="GeneID" id="3638810"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200810CA"/>
    <dbReference type="CGD" id="CAL0000181121">
        <property type="gene designation" value="orf19.9591"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00810C_A"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="InParanoid" id="Q5AD24"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000181121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32477" checksum="FD8D7AC8669405AF" modified="2005-04-26" version="1">MLSKIKLLGSRKCFSTWSILAHENPLGIPRLAGKPNSIPKASKGLPIRQKIPNVSNIILISSAKGGVGKSTVSVNTALALNSLGKKVGILDADIFGPSIPKLMNLKGEPRLSSSGKLLPLSNYGVQTMSMGYLIDEKQAITWRGLMVMKALQQLLFEVEWSPIDYLVVDMPPGTGDTQLSIGQLLQITGAIIVSTPQDIALIDAVKGITMFNKINIPLIGMVQNMSHFICPNCKHESHIFKNKGAERVALENNLKVLSSIPLNEEICVQSDVGKPIVISDPNSEIAKPYFDIAKAIVDFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-10-29" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADM9</accession>
    <accession>A0A1D8PKL8</accession>
    <name>PMT2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase 2</fullName>
            <shortName>Protein mannosyltransferase 2</shortName>
            <ecNumber evidence="2 13">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PMT2</name>
        <name type="ordered locus">CAALFM_C306890WA</name>
        <name type="ORF">CaO19.14104</name>
        <name type="ORF">CaO19.6812</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Infect. Immun." volume="73" first="4571" last="4580">
            <title>Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.</title>
            <authorList>
                <person name="Rouabhia M."/>
                <person name="Schaller M."/>
                <person name="Corbucci C."/>
                <person name="Vecchiarelli A."/>
                <person name="Prill S.K."/>
                <person name="Giasson L."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="16040968"/>
            <dbReference type="DOI" id="10.1128/IAI.73.8.4571-4580.2005"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="55" first="546" last="560">
            <title>PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.</title>
            <authorList>
                <person name="Prill S.K."/>
                <person name="Klinkert B."/>
                <person name="Timpel C."/>
                <person name="Gale C.A."/>
                <person name="Schroppel K."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="15659169"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04401.x"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Proteomics" volume="6" first="S74" last="81">
            <title>Proteomic analysis of detergent-resistant membranes from Candida albicans.</title>
            <authorList>
                <person name="Insenser M."/>
                <person name="Nombela C."/>
                <person name="Molero G."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="16534748"/>
            <dbReference type="DOI" id="10.1002/pmic.200500465"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Fungal Genet. Biol." volume="43" first="124" last="134">
            <title>Genomic response programs of Candida albicans following protoplasting and regeneration.</title>
            <authorList>
                <person name="Castillo L."/>
                <person name="Martinez A.I."/>
                <person name="Garcera A."/>
                <person name="Garcia-Martinez J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Valentin E."/>
                <person name="Sentandreu R."/>
            </authorList>
            <dbReference type="PubMed" id="16455273"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2005.12.002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="715" last="725">
            <title>Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.</title>
            <authorList>
                <person name="Cantero P.D."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="21375589"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07604.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E37768" last="E37768">
            <title>Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans.</title>
            <authorList>
                <person name="Wang L."/>
                <person name="Jia Y."/>
                <person name="Tang R.J."/>
                <person name="Xu Z."/>
                <person name="Cao Y.B."/>
                <person name="Jia X.M."/>
                <person name="Jiang Y.Y."/>
            </authorList>
            <dbReference type="PubMed" id="22662216"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0037768"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Essential protein that plays an important role in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">PMT1 and PMT2 form a functional heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10 12">Associates with lipid rafts in a RTA2-dependent manner.</text>
    </comment>
    <comment type="induction">
        <text evidence="7 9 11">Transcribed in the yeast form, but expression is increased two to threefold during hyphal induction. Also induced during cell wall regeneration. Up-regulated more than twofold when PMT1 expression is impaired. MSB2 functions not only to secure basal levels of the PMT2 transcripts but is needed also for up-regulation of both transcripts upon PMT1 inhibition.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7 8">Disruption of both alleles leads to letality. Disruption of only one allele impairs filamentation and leads to an altered cell wall composition with reduced amounts of beta-1,6-glucan and shows reduced virulence in a mouse model of hematogenously disseminated candidiasis (HDC) and using reconstituted human epithelium (RHE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="2 13"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719907.1">
        <property type="nucleotide sequence ID" value="XM_714814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADM9"/>
    <dbReference type="SMR" id="Q5ADM9"/>
    <dbReference type="FunCoup" id="Q5ADM9">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADM9"/>
    <dbReference type="GlyCosmos" id="Q5ADM9">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_06890W_A-T">
        <property type="protein sequence ID" value="C3_06890W_A-T-p1"/>
        <property type="gene ID" value="C3_06890W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638538"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306890WA"/>
    <dbReference type="CGD" id="CAL0000187219">
        <property type="gene designation" value="PMT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06890W_A"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="InParanoid" id="Q5ADM9"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="BRENDA" id="2.4.1.109">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="PHI-base" id="PHI:454"/>
    <dbReference type="PRO" id="PR:Q5ADM9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000430577" description="Dolichyl-phosphate-mannose--protein mannosyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="3">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="3">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="3">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="3">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="3">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=8" evidence="3">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=9" evidence="3">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=10" evidence="3">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="MIR 1" evidence="4">
        <location>
            <begin position="342"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MIR 2" evidence="4">
        <location>
            <begin position="412"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="MIR 3" evidence="4">
        <location>
            <begin position="474"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P31382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P33775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15659169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
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    </evidence>
    <evidence type="ECO:0000269" key="9">
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            <dbReference type="PubMed" id="16455273"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000303" key="13">
        <source>
            <dbReference type="PubMed" id="15659169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="14"/>
    <sequence length="769" mass="88372" checksum="4E847200A44585C0" modified="2005-04-26" version="1">MSTSVEPNETEALLRKQNDLSTTASIEEKYPHQQGEAAEDDDDTLKRTQYDEAKETAESLKQVESILAPIVFTALSFFVRFYRISVNDHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPSGEKYPDYIDYTKMRLFNATFSALCVPLAYFTGKEVGFSMFTTWLFTLMVALESSYVTLGKFILLDSMLLFFTVATVFCFSRFNNFNNKSQEFSRKWWKWILLTGVSIGCTCSVKMVGLFVTTLVGIYTVVDLWNKLSDKSISWTKYIQHWFARIVALILVPIFIFMLSFKVHFDLLYKSGTGDANMSSLFQANLAGSDVGGGPREVSMFHSVITLKNQGLSGGLLHSHVQTFPEGSKQQQVTTYGHKDSNNNWIFQRARGQPYYDTSGNTTDIEYIFDGMHVRLMHPQTGRNLHTHDIPAPVSKSEYEVACYGNLTIGDPKDNWTVEIMEQASDEDKMRLHPLTSSFRLKNEVMNCYLGVTGTTLPQWGFRQGEVVCYKNPFKKDKRTWWNIENNRNAVLPPAPEDFKLPKTKFIRDFIQLNLAMMATNNALVPDTEKQDDLASSFWQWPTLNVGIRMCGWGPENPKYYMIGSPATTWTSTVGVILFAFIVLYYLIRWQRQYVDFPSTNPHKLKLFLMGGIYPMFGWGLHFLPFAIMGRVTYVHHYVPALYFAMLVFCYEVESFSSRLNKPNASPVSKLLYLAIYIGLLSLVAGTFWYFRYLSWGMEGPKEDWKHLKLLESWRVSDDQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADT3</accession>
    <name>Q5ADT3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C307330WA</name>
        <name evidence="9" type="ordered locus">orf19.14050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="15123810"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR006977">
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    </dbReference>
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    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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            <end position="180"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="293"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="32"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361264"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="AOW28737.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="297" mass="32727" checksum="53A54C8711222045" modified="2005-04-26" version="1">MSSSNHVTPDIDEFIIPDDSETPNAPRNNQGGASPFSPFNFLPKVDLSSTFGNSSGQLPVNVKIKERQYSGGDTLDEPVWVTLKRDLLQIGKRLAIVIWPMQLAQLAKKQQSRFVSFANSNGIHIPERLGNILPGGGVDDNTEQTTGISSNDLISQDNLDWDLWGPLIFSLVFAIVLAFTNESQSTEVFSGSFAFIWIFYFVIGLNVQLLGGTISFLSAISAIGYSMFPIVIGEVICTLLIHWRWIRLLIMLVLNAWSIYAGVMSVKCSGVFPGRVALAMYPVGLFYSVLSWLVIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADU9</accession>
    <name>Q5ADU9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C307460WA</name>
        <name evidence="10" type="ordered locus">orf19.14034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719840.1">
        <property type="nucleotide sequence ID" value="XM_714747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADU9"/>
    <dbReference type="SMR" id="Q5ADU9"/>
    <dbReference type="FunCoup" id="Q5ADU9">
        <property type="interactions" value="847"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADU9"/>
    <dbReference type="GeneID" id="3638480"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307460WA"/>
    <dbReference type="CGD" id="CAL0000184913">
        <property type="gene designation" value="orf19.14034"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07460W_A"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007683_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADU9"/>
    <dbReference type="OMA" id="DQTVIHC"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000032">
        <property type="entry name" value="CTD phosphatase-related (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="161"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="516"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000184913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="768" mass="87072" checksum="17A94C1AA5786DA0" modified="2005-04-26" version="1">MSDLTPIKLPSSAPFPVVISSVLCKPGDTISKHKTIFKYKYWDYQDDPTSKEDPPKKIRVERLGTFESPIEGEIDQINIKPLQEVMHSDVDLLFVKEACPHTVQYSGLCALCGKSLEEEKDYSGYNYEDRATIEMSHDNTGLKISFDEAAKIEHNTTDRLIDERKLILVVDLDQTVIHATVDPTVGEWQSDPANPNYAAVKDVKTFCLEEEAIVPPGWTGPKLAPTKCTYYVKLRPGLSEFLEKMAEKYEMHIYTMATRNYALSIAKIIDPDGKYFGDRILSRDESGSLTHKNLKRLFPVDQSMVVIIDDRGDVWQWESNLIKVVPYDFFVGIGDINSSFLPKKNGQLTGPTKKRKSIAKLEAAAELAKESDTNNDKQETESGEEEGEEDADGHSDVSNSPVERILELGGGEGNTSLLLEQSLTRNQSIEEQQQKRPLAKLQHDLEQMHEHRHDSDSKSESGSDDESDEEDNLLFDDDNELAALDKVLGNIHQGYYNLFDKDKINKPDLTEIIPSMKSKTLEGITVLFSGIIPLGINLDSADIVIWCRQFGVKVVNEVYPEVTHVVCRDVSEGAGPTFKTRVARKLYPDTIKIVNPDWLFACLSNWTKVDEKDYLISTDDTKLWTVKENEITKYQKALEDRSALANATHIDSIESFDEYDLDEANQEVDDFLAGLSDDDEEEEEEEEDEEIENPESNNDDEEIYEQSTNGHDSFIKDAYSKKRNRDEEEVQLVKKQKIENGENGENENENDLDDLEKELLDGFDDLEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFK3</accession>
    <accession>A0A1D8PQM6</accession>
    <accession>Q3MPS7</accession>
    <name>PSF3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PSF3</name>
        <name type="ordered locus">CAALFM_C700530CA</name>
        <name type="ORF">CaJ7.0068</name>
        <name type="ORF">CaO19.7065</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720357.1">
        <property type="nucleotide sequence ID" value="XM_715264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFK3"/>
    <dbReference type="SMR" id="Q5AFK3"/>
    <dbReference type="FunCoup" id="Q5AFK3">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFK3"/>
    <dbReference type="EnsemblFungi" id="C7_00530C_A-T">
        <property type="protein sequence ID" value="C7_00530C_A-T-p1"/>
        <property type="gene ID" value="C7_00530C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637999"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700530CA"/>
    <dbReference type="CGD" id="CAL0000201451">
        <property type="gene designation" value="PSF3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00530C_A"/>
    <dbReference type="HOGENOM" id="CLU_081646_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AFK3"/>
    <dbReference type="OMA" id="AAYKEIY"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000278416" description="DNA replication complex GINS protein PSF3">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="177" mass="20246" checksum="EE2C13FF229F2BCA" modified="2005-04-26" version="1">MTTDYYDLDDILADSEKLTCKFNITVPGLGYLEGNPGKPIHEDTKLELPHWLSGILATVAIDEDSNINFLDLADPDIIKEKVINAIKTDPLAVDLHKLTPYYYSLILKWGNLYTDKTLIANVMNCLKARSLEIYNFSNNANKTLNNEFLYTLDEFERALFKSTSDSNKSMRKWLKTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-08" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFT2</accession>
    <accession>A0A1D8PLI7</accession>
    <accession>Q5AF45</accession>
    <name>GPI11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GPI11</name>
        <name type="ordered locus">CAALFM_C402420CA</name>
        <name type="ORF">CaO19.10277</name>
        <name type="ORF">CaO19.2761</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720511.1">
        <property type="nucleotide sequence ID" value="XM_715418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFT2"/>
    <dbReference type="FunCoup" id="Q5AFT2">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFT2"/>
    <dbReference type="GlyCosmos" id="Q5AFT2">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_02420C_A-T">
        <property type="protein sequence ID" value="C4_02420C_A-T-p1"/>
        <property type="gene ID" value="C4_02420C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637849"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402420CA"/>
    <dbReference type="CGD" id="CAL0000185478">
        <property type="gene designation" value="orf19.10277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02420C_A"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069429_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AFT2"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="PRO" id="PR:Q5AFT2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000191763" description="Glycosylphosphatidylinositol anchor biosynthesis protein 11">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="265" mass="29810" checksum="0602081010A35A9D" modified="2005-04-26" version="1">MPAAIRPMKKTVSFSKDVSNNNNNLESDSDTKQSPQSYLTFIPQIKNSLLVVPFHNIFILVGMFYSGLTQDLETVMWKGFLTSIPIQVIYNYIIYINLLPLKKSTRNDHQNNSSGSAINNNNNNNNNNVPLLIGSSIFVSIVLSLPLFVVIILMGAPVYKYSLKTLYLSLHLSQLIFNPLIILSNLNVNKIKRLFKQDHLYRIIFHHGILSSVLLTLGGCWLGVIPIPLDWDRPWQQWPITLLVGGYLGGVVGGVLSLIVNYFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGV1</accession>
    <accession>Q3MPJ8</accession>
    <name>Q5AGV1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gir2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">GIR2</name>
        <name evidence="4" type="ordered locus">CAALFM_C701420WA</name>
        <name evidence="3" type="ordered locus">orf19.13940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721423.1">
        <property type="nucleotide sequence ID" value="XM_716330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGV1"/>
    <dbReference type="SMR" id="Q5AGV1"/>
    <dbReference type="FunCoup" id="Q5AGV1">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AGV1"/>
    <dbReference type="GeneID" id="3636962"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701420WA"/>
    <dbReference type="CGD" id="CAL0000185013">
        <property type="gene designation" value="GIR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01420W_A"/>
    <dbReference type="eggNOG" id="KOG4018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084528_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AGV1"/>
    <dbReference type="OMA" id="QWDEHKK"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
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                <person name="Dungan J."/>
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        </source>
    </evidence>
    <sequence length="237" mass="26036" checksum="9BDF2E5D3771A259" modified="2005-04-26" version="1">MSQEEQSGHLSPQEPREEALTVTSQSEPSATTPKSDDQNAADPQPEQQPQLNQEQDEFQNNLTLPISKIKKIFKMDPEYTGASASAVYTAGLATELFVQYFAEQASLLAKMEKRKKIQYKDFSNAVASHDALNFLSDTIPRTQPIGELVQQKKINVKQTAPKTTKDNGDVNANPQVGDIVKKDLLVKGQQTLNFPIANSASSKTPEGPVKKSVISNLVTTEDDRSTKDGDDDVVMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI78</accession>
    <name>Q5AI78_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ypt7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">YPT7</name>
        <name evidence="8" type="ordered locus">CAALFM_C102870WA</name>
        <name evidence="7" type="ordered locus">orf19.10492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721474.1">
        <property type="nucleotide sequence ID" value="XM_716381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI78"/>
    <dbReference type="SMR" id="Q5AI78"/>
    <dbReference type="STRING" id="237561.Q5AI78"/>
    <dbReference type="GeneID" id="3636864"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102870WA"/>
    <dbReference type="CGD" id="CAL0000178854">
        <property type="gene designation" value="YPT7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02870W_A"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_0_1"/>
    <dbReference type="InParanoid" id="Q5AI78"/>
    <dbReference type="OMA" id="ERCIDHE"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000178854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW25968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="288" mass="32059" checksum="A31254AD6EEDB79A" modified="2005-04-26" version="1">MSKHRLTNNKNNTNGISKPSSNSVSVENSSTNNPKAGPTPTLKVVLLGDSGVGKTCLRSQFVHHVFTNAYKATIGGDYLTTSVVLPQQIQQSQLSSSTSSLDIKSNFATTRLPSTNTKVNLQIWDTAGQERFNSISQAFYRGTDVCVLVYDVTNYESVLSIRDWFNRFMEHCHVEFPGIVIVGNKSDKSTDRCVDLNEIKDIVTTNTTFANVGDYIDDWDNSLMEISAKRLELVEELFVRVAKIGVDLLMGNKGDNKRRLQQFDKIDLRETHNRINDNTTSTSSSCAC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJ85</accession>
    <accession>A0A1D8PJ69</accession>
    <name>RRT14_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Regulator of rDNA transcription 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RRT14</name>
        <name type="ordered locus">CAALFM_C301430WA</name>
        <name type="ORF">CaO19.1708</name>
        <name type="ORF">CaO19.9275</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in ribosome biogenesis, probably through modulation of rDNA transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRT14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721779.2">
        <property type="nucleotide sequence ID" value="XM_716686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJ85"/>
    <dbReference type="SMR" id="Q5AJ85"/>
    <dbReference type="FunCoup" id="Q5AJ85">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJ85"/>
    <dbReference type="EnsemblFungi" id="C3_01430W_A-T">
        <property type="protein sequence ID" value="C3_01430W_A-T-p1"/>
        <property type="gene ID" value="C3_01430W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636633"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301430WA"/>
    <dbReference type="CGD" id="CAL0000186307">
        <property type="gene designation" value="orf19.9275"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01430W_A"/>
    <dbReference type="eggNOG" id="ENOG502S1G1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095038_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AJ85"/>
    <dbReference type="OMA" id="LNNTKQV"/>
    <dbReference type="OrthoDB" id="4069371at2759"/>
    <dbReference type="PRO" id="PR:Q5AJ85"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031404">
        <property type="entry name" value="Rrt14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17075">
        <property type="entry name" value="RRT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000404336" description="Regulator of rDNA transcription 14">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="219" mass="24911" checksum="20102BE4075F79F4" modified="2017-05-10" version="2">MSFNSNASKYQAENTVDKLFSNILHTSTTSKSVSKSKSKSKSKPKPISSTQLLVNQLQSTNTTANNNNTKRKKHNNNKRINKTLLEEKKFSKFIKYNHIKQKSNKSELDEKYLNKLVRKNINSLNKINKIDDLLIDEELNQIKQELLEENEFVGMGGGQLKGGKRLRKKLLNNTKQVIDEFDGFGEISSSNNNNKKKNSSYPGLTPGLAPVDYEEEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALM6</accession>
    <name>Q5ALM6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">CPR3</name>
        <name evidence="12" type="ordered locus">CAALFM_C202320CA</name>
        <name evidence="11" type="ordered locus">orf19.9126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722595.1">
        <property type="nucleotide sequence ID" value="XM_717502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALM6"/>
    <dbReference type="SMR" id="Q5ALM6"/>
    <dbReference type="STRING" id="237561.Q5ALM6"/>
    <dbReference type="GeneID" id="3635812"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202320CA"/>
    <dbReference type="CGD" id="CAL0000193429">
        <property type="gene designation" value="CPR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02320C_A"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="InParanoid" id="Q5ALM6"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000193429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW27272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="191" mass="20979" checksum="FEAB7D9C3C59F580" modified="2005-04-26" version="1">MFKTTLTKPLTFKSARFFSTTPRAWGTKVFFNTSINGEKQPPITFELYDDVTPITAENFRVLCTGEKGVGYKGSIFHRIIPQFMLQGGDFETGKGYGGYSPTHNNDKFNDENFIKKHDRPGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVVDGFDVVKKIESCGTSSGTPSASVVIEESGEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALW6</accession>
    <name>Q5ALW6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C201530CA</name>
        <name evidence="10" type="ordered locus">orf19.9035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722510.1">
        <property type="nucleotide sequence ID" value="XM_717417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALW6"/>
    <dbReference type="SMR" id="Q5ALW6"/>
    <dbReference type="FunCoup" id="Q5ALW6">
        <property type="interactions" value="778"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ALW6"/>
    <dbReference type="GeneID" id="3635803"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201530CA"/>
    <dbReference type="CGD" id="CAL0000191648">
        <property type="gene designation" value="orf19.9035"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01530C_A"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="InParanoid" id="Q5ALW6"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000191648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="714" mass="81130" checksum="A7847753062EF17B" modified="2005-04-26" version="1">MGNYITVATCNLNQWALDFEGNRDRIFESIKEAKRQGAKLRVGPELEVCGYGCLDHFAENDLYRHSWEVYGEILSNPETHGILLDIGIPIIHKSIKYNCRIISYNGKILLIRPKIYLANDGNYREMRYFTGWNRPKYHEEYQLPKFISKITGQARVPFGDCIVQTLETRLGCETCEELFTPESPHIAMALDGVEIFTNSSGSHHELRKLDTRLKLITEATKKCGGIYLYANQKGCDGDRLYYDGCASIIVNGNVLAQASQFSLKDVEVISATVDLDDVRAYRNQKSASVQAVNQSEKFKVIYTDVELSPSDYVFDHSIIPSKPQPIKYHTPEEEIALGPACWLWDYLRRSKCGGYFLPLSGGIDSCATAVIVHSMCRLVVEAIPNDEQVLKDIQAITHDEGFVPKTPQDIAQRIFYTSFMGTENSSKETRSRSKELASKIGSYHVDLNMDNLVTSVVSLFEVATGKKPIFKIFGGSNTENLALQNIQARLRMVLSYLFAQLLPWTRGKNVPGLLVLGSANVDECLRGYLTKYDCSSADINPIGGISKTDLKRFIAWAEKNFDLPILHEFLTATPTAELEPITKDYVQSDEIDMGMTYDELSRFGTLRKVDKCGPLAMFIKLYHEWSQPPYNLSAKQIAEKVKRFWFFYAINRHKMTTMTPAYHAEQYSPDDNRFDLRPFLINPRFPHASKKIDELVEEIEKRQHEIDSSNKSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMQ8</accession>
    <name>Q5AMQ8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C402040WA</name>
        <name evidence="2" type="ordered locus">orf19.12058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722661.1">
        <property type="nucleotide sequence ID" value="XM_717568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMQ8"/>
    <dbReference type="SMR" id="Q5AMQ8"/>
    <dbReference type="FunCoup" id="Q5AMQ8">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AMQ8"/>
    <dbReference type="GeneID" id="3635649"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402040WA"/>
    <dbReference type="CGD" id="CAL0000195279">
        <property type="gene designation" value="orf19.12058"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02040W_A"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_10_1_1"/>
    <dbReference type="InParanoid" id="Q5AMQ8"/>
    <dbReference type="OMA" id="RAVVKCC"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000195279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="477" mass="54615" checksum="6F1CCB49AB0B7CE8" modified="2005-04-26" version="1">MPHKKVVIVGGGISGIKAAADLYKSGIKSTVILEAQPRLGGRLFTVESTQNKGTTYDYGASWFHDCLNNPLFDKAQQLENVKYYFDDGKSLYFNKFEGQIEKWRFETVLEEMMTYFQWVYKQDPDKLDISVKQLAQEYVDKYRNVLTKEQIELSLSAVRMWSELWHGESWDLLSGKYTFADDGHLGRNAFVKNGYSTVFINELKELPRAYRDSAIKLNAQVIKIDYTNKKKILVYLKDGRTYSCDYIIVTIPQTILKITNAKDENYVEWVPELPPNIQKVLPDVHFGSLGKVVLEFDDCFWPRDVDRFYGLTSNTPSQDTISVDAWDYPTILINYQAVNNVPSLVALTQNPLSKYIENLQPHEKQQRIWSIFKPLIAKICESKGIQDIPEPHSIYHTPWNNESLFRGSYGTSLVGTQDPSSVIKAFVDGYQDRIKFAGAETMDDTSNGCAHGGWFSGQREAKFIVQQEAKKKVDSKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMR5</accession>
    <accession>A0A1D8PLF8</accession>
    <name>GPI14_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>GPI mannosyltransferase 1</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GPI mannosyltransferase I</fullName>
            <shortName>GPI-MT-I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycosylphosphatidylinositol-anchor biosynthesis protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GPI14</name>
        <name type="ordered locus">CAALFM_C402100CA</name>
        <name type="ORF">CaO19.12050</name>
        <name type="ORF">CaO19.4581</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722653.1">
        <property type="nucleotide sequence ID" value="XM_717560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMR5"/>
    <dbReference type="SMR" id="Q5AMR5"/>
    <dbReference type="FunCoup" id="Q5AMR5">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AMR5"/>
    <dbReference type="EnsemblFungi" id="C4_02100C_A-T">
        <property type="protein sequence ID" value="C4_02100C_A-T-p1"/>
        <property type="gene ID" value="C4_02100C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635641"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402100CA"/>
    <dbReference type="CGD" id="CAL0000197470">
        <property type="gene designation" value="GPI14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02100C_A"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024220_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AMR5"/>
    <dbReference type="OMA" id="LINCWIL"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="PRO" id="PR:Q5AMR5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180041">
        <property type="term" value="F:dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246226" description="GPI mannosyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="398" mass="46549" checksum="4DC724FEFD433E26" modified="2005-04-26" version="1">MSQLKYLITFSILLRFGFFFFGLYQDEYMPVKYTDIDYLVFNDASKFVYQGLSPYLRETYRYTPILAILLIPDNFGKYWYHFGKLLFMVSDVITGLIILKLLSKQQQLSEKKKMILSSIWLLNPMVITISTRGSAESVLTVMIMLSLYYLLDKDNVILSAIWLGLSIHFKIYPIIYLPSILYYLSSQETPFLASVPGINLVNAKNLKYIIITLTTLAVVNYLMFLKYGWEFIDNSYLYHVTRLDHRHNFSVYNMVLYYKSALLEDSNGFDIEKIAFVPQLLLSAVIIPLIFAKEDLISSLFIQTFVFVAFNKVITSQYFIWFLIFLPHFLSKTKLLTTDKITGISCLLLWIISQATWLYFAYKLEFLGENTFDNGLMYSSVFFFLSNCWCTMKFIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANK5</accession>
    <name>Q5ANK5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C304450CA</name>
        <name evidence="3" type="ordered locus">orf19.13317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723112.1">
        <property type="nucleotide sequence ID" value="XM_718019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANK5"/>
    <dbReference type="FunCoup" id="Q5ANK5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANK5"/>
    <dbReference type="GeneID" id="3635207"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304450CA"/>
    <dbReference type="CGD" id="CAL0000200727">
        <property type="gene designation" value="orf19.13317"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04450C_A"/>
    <dbReference type="eggNOG" id="ENOG502QWHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026108_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ANK5"/>
    <dbReference type="OMA" id="NVAFCQT"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971235" evidence="2">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000200727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="279" mass="29853" checksum="009418BD669D6BF8" modified="2005-04-26" version="1">MYFHSFIISSLITSAFANPIKKCGFPQDEDITNVGANGWAMSPDEPCTPGKFCPFACPPGKLMNQWDPEAVSYTFPKSMNGGLYCNEDGTTSKPFIGRSLCIDGVGTVSVVNKASDVVSFCQTVLPGNEAMLIPTEVGDGDEQVLAVPGPGYWAGTAAHYYVNLPGVSSKDACVWGTPEKAIGNWSPYVAGMNQDSNGNTFVTIGYNPKYIDDFSGNIPNFGIRIVCDNPDECNGLECEINPRQGFNKAMGPASGNSLGADYCIVTAKNHAHARIEVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AP58</accession>
    <name>Q5AP58_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C110340WA</name>
        <name evidence="3" type="ordered locus">orf19.12370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723587.1">
        <property type="nucleotide sequence ID" value="XM_718494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AP58"/>
    <dbReference type="STRING" id="237561.Q5AP58"/>
    <dbReference type="GeneID" id="3634909"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110340WA"/>
    <dbReference type="CGD" id="CAL0000198270">
        <property type="gene designation" value="orf19.12370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10340W_A"/>
    <dbReference type="eggNOG" id="ENOG502RXU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033727_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AP58"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000198270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56577" checksum="5AE85AFCF7D2AFFD" modified="2005-04-26" version="1">MSPKYKNYSVINYLAFNYAGFACVAIIVFLSSTQPFFIKEIIGIDPTTATTSTTSTSKNSKDGKIGHIVGGLGFIDELTAMIVAPLLGALNDNLNSKQYNGSKLIQSFSFIIIAISLFGYAVWCKNLVPDMFIFRSIFAIGVTGCMSMVTVILNELTISDFEFWRSNKQVTSQYIPLNQEEEGEDSDEQQQHTSPDTLKKNGKFAGLMGVCTGLGAIFSVSVFVTLPINLGMKNAYLVVMGFALLSFAILFSFLYNVNGKDNTDNNENDNNDNNNNDISTKNESYFQLLIHGYEFSKHNKQAQLAYAGSFVARSTTVATAMFIPLMVYEWYYTIGQCKSNNDNEWAGKLTCHEGYVFAAILSGVAQTVALISAPIWGYLVDARRIGKCNTLGLAAIVGMIGNFGLSLIHSYSSNTYNPKTFICFFMISIIGLSQIGLIISSMSVLSGIPNAHDIMGSLSGLYSFCGGIGIMIISSLGGYLSDHWILGPFFILGLFNVALLVIYYSYSRQQKSGNLVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2025-06-18" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q8NJN3</accession>
    <accession>A0A1D8PD92</accession>
    <accession>Q59VM9</accession>
    <name>ACS2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Acetyl-coenzyme A synthetase 2</fullName>
            <ecNumber>6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acetate--CoA ligase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Acyl-activating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ACS2</name>
        <name type="ordered locus">CAALFM_C104290CA</name>
        <name type="ORF">CaO19.1064</name>
        <name type="ORF">CaO19.8666</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2002-08" db="EMBL/GenBank/DDBJ databases">
            <title>Acetyl-CoA synthetase 2 of Candida albicans.</title>
            <authorList>
                <person name="Jones P.M."/>
                <person name="Clarkson J.M."/>
                <person name="Wheals A.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-581</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW26103" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
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        <property type="protein sequence ID" value="AOW26103.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AAN01233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019475093.1"/>
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    <dbReference type="PDB" id="7KDS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A=2-671"/>
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    <dbReference type="PDB" id="8V4O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B/C=2-671"/>
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    <dbReference type="PDB" id="8V4P">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
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    <dbReference type="PDB" id="8W0C">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
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    <dbReference type="PDB" id="8W0D">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B/C=2-671"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.95 A"/>
        <property type="chains" value="A/B/C=2-671"/>
    </dbReference>
    <dbReference type="PDB" id="8W0J">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.85 A"/>
        <property type="chains" value="A/B/C=2-671"/>
    </dbReference>
    <dbReference type="PDB" id="8W0L">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="A/B/C=2-671"/>
    </dbReference>
    <dbReference type="PDB" id="8W0M">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B/C=2-671"/>
    </dbReference>
    <dbReference type="PDBsum" id="7KDS"/>
    <dbReference type="PDBsum" id="8V4O"/>
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    <dbReference type="AlphaFoldDB" id="Q8NJN3"/>
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        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q8NJN3">
        <property type="interactions" value="786"/>
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    <dbReference type="STRING" id="237561.Q8NJN3"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C104290CA"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="InParanoid" id="Q8NJN3"/>
    <dbReference type="OMA" id="TVHTKKI"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
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    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
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    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
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    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
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    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
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    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
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    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
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    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
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    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24095:SF245">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
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    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
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        <property type="entry name" value="AMP_BINDING"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
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    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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    <feature type="binding site" evidence="1">
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        <ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57287"/>
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    <feature type="binding site" evidence="1">
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        <ligand>
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    <feature type="binding site" evidence="1">
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        <ligand>
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    <feature type="binding site" evidence="1">
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        <ligand>
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    <feature type="binding site" evidence="1">
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            <position position="532"/>
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        <ligand>
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    <feature type="binding site" evidence="1">
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        <ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="543"/>
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        <ligand>
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    <feature type="binding site" evidence="1">
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        <ligand>
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    <feature type="sequence conflict" description="In Ref. 4; AAN01233." evidence="2" ref="4">
        <original>VIAYVA</original>
        <variation>ALLTLP</variation>
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            <begin position="576"/>
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            <begin position="342"/>
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            <begin position="351"/>
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    <sequence length="671" mass="73890" checksum="D4989ED9167F197D" modified="2017-05-10" version="3">MPTEQTHNVVHEANGVKLRETPKEFFERQPNKGHIHDVNQYKQMYEQSIKDPQGFFGPLAKELLSWDHDFHTVKSGTLKNGDAAWFLGGELNASYNCVDRHAFANPDKPALICEADDEKDSHILTYGDLLREVSKVAGVLQSWGIKKGDTVAVYLPMNAQAIIAMLAIARLGAAHSVIFAGFSAGSIKDRVNDASCKALITCDEGKRGGRTTNIKKLCDEALVDCPTVEKVLVYKRTNNPEIHLTEGRDYYWDVETAKFPGYLPPVSVNSEDPLFLLYTSGSTGTPKGVVHSTAGYLLGAALSTKYIFDIHPEDILFTAGDVGWITGHTYALYGPLLLGVPTIIFEGTPAYPDYGRFWQIVEKHKATHFYVAPTALRLLRKAGEQEIVKYDLSSLRTLGSVGEPISPDIWEWYNEFVGKNQCHISDTYWQTESGSHLIAPLAGVVPNKPGSASYPFFGIDAALIDPVTGVEIEGNDAEGVLAIKDHWPSMARTVYKNHTKYMDTYMNPYPGYYFTGDGAARDHDGYYWIRGRVDDVVNVSGHRLSTAEIEAALIEDKKVSEAAVVGIHDDITGQAVIAYVALKEGNSDEDSEGLRKELVLQVRKTIGPFAAPKSVIIVQDLPKTRSGKIMRRILRKVSSNEADQLGDISTLSNPQSVEGIISAFGAQFGKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-23" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q96UX5</accession>
    <accession>A0A1D8PGX8</accession>
    <accession>Q5AHB4</accession>
    <name>HSP78_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein 78, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSP78</name>
        <name type="ordered locus">CAALFM_C203390CA</name>
        <name type="ORF">CaO19.8501</name>
        <name type="ORF">CaO19.882</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2001-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Candida albicans HSP78 gene encoding a member of the ClpB family of stress proteins.</title>
            <authorList>
                <person name="Bhattacherjee V."/>
                <person name="Hostetter M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer, forming a ring with a central pore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer. NBD1 is primarily responsible for ATP hydrolysis. NBD2 is crucial for oligomerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpA/ClpB family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAK97626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AOW27375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715912.2"/>
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    <dbReference type="BioGRID" id="1220336">
        <property type="interactions" value="1"/>
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        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q96UX5"/>
    <dbReference type="EnsemblFungi" id="C2_03390C_A-T">
        <property type="protein sequence ID" value="C2_03390C_A-T-p1"/>
        <property type="gene ID" value="C2_03390C_A"/>
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    <dbReference type="GeneID" id="3637414"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203390CA"/>
    <dbReference type="CGD" id="CAL0000189244">
        <property type="gene designation" value="HSP78"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03390C_A"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_5_0_1"/>
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    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="PRO" id="PR:Q96UX5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000005499" description="Heat shock protein 78, mitochondrial">
        <location>
            <begin position="74"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD2" evidence="1">
        <location>
            <begin position="460"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="337"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="534"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAK97626." evidence="3" ref="1">
        <original>M</original>
        <variation>I</variation>
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAK97626." evidence="3" ref="1">
        <original>L</original>
        <variation>P</variation>
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAK97626." evidence="3" ref="1">
        <original>V</original>
        <variation>G</variation>
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAK97626." evidence="3" ref="1">
        <original>GG</original>
        <variation>LT</variation>
        <location>
            <begin position="543"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="812" mass="91657" checksum="A7C1CDB57C743267" modified="2017-05-10" version="2" precursor="true">MLSSRIPKGKLLKQTSATSYLNLAKSMPITTARYRPNQYYANELAKLNVFTIHNIPSPCFSQVRNFHSSFPRKLQMQQTEQGDNRPALEKFGSDLTQLAKEGKLDPVIGRDHEIRRTIQILSRRTKNNPVLIGNAGTGKTAVMEGLAQRIIRGEVPDSMKDKQIITLDLAGIISGAKYRGDFESKLKSILKEVEEKNGKVILFIDEFHLLMGLGKAEGSIDASNLLKPALARGKLSMCGATTIEEYRKYVEKDAALARRFSPVTVNEPTVEDTISILRGLKERYEVHHGVRIMDSALVTAALYSNRYITDRFLPDKAIDLVDEASSTLRLQHESRPDAIATLDRQIMTIEIELESLRKEEDQLSIDRKHKLEKELEVKKSELKELTDQWESEKRAIDAVKNAKSELEKAKYELEQATREGDYARASRIQYASIPELQDKIQELSKNELAAKSSNLLHDSVTSEDIAGVISKMTGIPVNNLLKGEKDKLLDMNILLRQSVVGQDEAIDAVSDAVRLQRAGLTSENRPIASFMFLGPTGTGKTEGGKSLAQFLFNDKNAVVRFDMSEFQEKHTISRLIGSPPGYVGYEESGELTEAVRRKPYSVVLFDEFEKAHPDLSKLLLQVLDEGSLTDSHGKKIDFKNTIIVMTSNIGQEILLADKNTYEDGHINSEVKSQVLENLRHHYAPEFLNRIDDIVVFNRLSKTALKEILDIRLREIGDRLVDKRIILQLTDEAKTLLCDMGYDPTYGARPLNRVLRKKLLDPLAMRLIKGQVQENETVKVEVKDHKIYVVPNHSEGTVIEKEEDYFKEDKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDE5</accession>
    <name>A0A1D8PDE5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C104860WA</name>
        <name evidence="3" type="ordered locus">orf19.8377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713567.1">
        <property type="nucleotide sequence ID" value="XM_708474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDE5"/>
    <dbReference type="SMR" id="A0A1D8PDE5"/>
    <dbReference type="FunCoup" id="A0A1D8PDE5">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDE5"/>
    <dbReference type="GeneID" id="3644784"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104860WA"/>
    <dbReference type="CGD" id="CAL0000177097">
        <property type="gene designation" value="orf19.8377"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04860W_A"/>
    <dbReference type="eggNOG" id="ENOG502QRMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDE5"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="374"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000177097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="856" mass="98020" checksum="51CD4F304971092E" modified="2017-01-18" version="1">MDAWNSATTFGADGLSGFSSQLPDILNLSDPLLAKIITSKKALQLLESNIVSGVSEDGEESNTNNENKAIIELLMSACDGDVVTLESITRSNPQIVNQLFPSDENGATALVYAVCFNNPDIVESLLENHKADPDIPDSIVNYTPIMWAVHLNYLNIVQLLLDHQADLFLSPKDDGTNASTLVFPENTEMYEYFRSHNLLKTNADNSQDIYQATSFLPQDDYEDDLSTKLKMHTITSNTIGNENEENSEPQVIGEDEEYNLAQDPILQQLPEFEYDKLLPEQYIKFTDSDIPTLLNYIFDLRSQTTYQHNTKLSAAIVFQLVRYSALKVESTELTDFLFDCFTARLRTITNTKSGAFNMAIQDDGKPANAMGAGDIVLLSYWLSSLQFLHFYFGKNNIYLKFPRFLQELINLVQSLTATLSFSINSRLNLLVDDCIINFTNLVDVSNVLYAKDWNLFKKNKSHPNTYDDIMNTLYPPTQMELMKPSPIRYLQVLGALDYVLRIHKVDNLLRSEAFSQVFYYINCTIFNRLISQSKYCSRAKAIQIRLNVSAIEDWLRSHNVKVYKPDTIGGLNKLLGNEDVKLHNLLNEDASLKHRKNPHYLQFYYNSLYHIGKNQLQPTIELLQWLQCMTSLSDEESLINTINQFDCLNYYQLFKVANKLYKYEVNEVKLPKKLIQVIKSLMTEQGPNQIQRMFLHYMTQTTFLSKEEYIYLNPNYIFEVALPNLTELINSYGAGLGGVRILRNKKYQPSLPISIMDDIDEKLTENRSWQNETYDYDNEKDGEDDEEEEHNEGANANGDSGSVHPSTFEKKPTHTKEIEDFKGDELFKQVQMPNSLLHKNWGDTSTGVEDFESNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDN9</accession>
    <name>A0A1D8PDN9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prn1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">PRN1</name>
        <name evidence="7" type="ordered locus">CAALFM_C105840WA</name>
        <name evidence="6" type="ordered locus">orf19.10004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718488.2">
        <property type="nucleotide sequence ID" value="XM_713395.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDN9"/>
    <dbReference type="SMR" id="A0A1D8PDN9"/>
    <dbReference type="STRING" id="237561.A0A1D8PDN9"/>
    <dbReference type="GeneID" id="3639882"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105840WA"/>
    <dbReference type="CGD" id="CAL0000200662">
        <property type="gene designation" value="PRN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05840W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDN9"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000200662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="345" mass="38457" checksum="B8C794B244FEE820" modified="2017-01-18" version="1">MSTRSIAKIVTANEQAEGAGARVRRSIGIMNQRNFDPFLMFDHFSSAGTNGFPEHPHRGQETITLVLNGAMAHEDFTGSKGILYAGDLQFMTAGKGVVHSEMPVANADGSPTVGLQLWVDLPNNMKGVKPRYRDLREWEIPEVVTDDGKVTIKVISGRSHGVESVKELAYTPINYYYYKVKAGGEFKQELQPGFNYFLYVLNGRNLVLNEDTKVDRYQNVFFGDKGDFITGKNAATKDNNETEVQFILVGGKKLEQEVVQYGPFVASSRDNIQKAFQDYQYGRNGFENIKTWQTLISGGVTKEMIEGPLNGNLEKRAAKKKAFLEKQQKKAAPVAAQPELVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDU9</accession>
    <name>A0A1D8PDU9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26 27" type="primary">GLT1</name>
        <name evidence="27" type="ordered locus">CAALFM_C106550WA</name>
        <name evidence="26" type="ordered locus">orf19.13636</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="28">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718845.2">
        <property type="nucleotide sequence ID" value="XM_713752.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDU9"/>
    <dbReference type="SMR" id="A0A1D8PDU9"/>
    <dbReference type="FunCoup" id="A0A1D8PDU9">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDU9"/>
    <dbReference type="GeneID" id="3639519"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106550WA"/>
    <dbReference type="CGD" id="CAL0000182870">
        <property type="gene designation" value="GLT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06550W_A"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDU9"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="25">
        <location>
            <begin position="50"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1180"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1186"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1191"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="CGD" id="CAL0000182870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="AOW26311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2126" mass="235366" checksum="A94C177C45E4C0CC" modified="2017-01-18" version="1">MSPSASYLPQEEFSTTNVYDYDEVPENKSWASSLPVAKGLYNPELEKDACGVGFTCHLKGVPSHKIVSDAKSLLCNMTHRGGELNPQDGDGAGLLSSIPHKFLKREFQYYCNVELPAKGQYGVGNVFFKKDDAVFEKSKKTFESIADSLGLKVLGWREVPHDSSILGAAALSREPYILQPAVVYKEIWGQKVSDDEFDSKYRKDFEKRLFILRKQASHTIGLHNWFYICSLSNKTIVYKGQLAPKQVYSYYHDLVNAEYESHFALVHSRFSTNTFPSWDRAQPLRLAAHNGEINTLRGNKNWMRAKEGVMKSKLFGDEMDKLFPIIEEGGSDSAAFDNVLELLVINGVVSLPEAVMMMIPEAWQNDENIDPKKKAFYEWAACLMEPWDGPALFTFADDRYCGANLDRNGLRPCRYYVIDDDRMICASEVGVIEIQPEKVIQKGRLQPGRMLLVDTKEGRIVDDRELKSKVASRYDFKSWVLANMISLQDLNEKLASRKIDINAKPIDVNVNVQSDPRLIAAGYSHEQILFVLAPMAEGNEALGSMGNDNALACISEQPKLLYEYFRQLFAQVTNPPIDPIREKIVMSLECYVGPQGNLLEMKPDQLNRLLLKSPILTSSELLAIKNIQTVYPSWSVANIDITFEKSEGIQGYINTIDRICQAASQAIADDNQIIILSDVATSAERLPISALIAVGAVHHHLVRQKQRSKVALIIETQEAKEVHHACCLVGYGADAINPYLAMETLVRMKHQGLLKNESLTEEKIIQNYKGSIDAGILKVMSKMGISTLASYKGAQIFEALGIDNSVIDRCFAGTASRIKGVTFEYIAQDAFTLHERGYPTRDTIKPIGLPETGEYHWRDGGDAHINDPAAIASLQDAVRNKNERAYEAYAKKENEAVRNCTLRGLLDFEFESSTEVPIDQVEPWTEIVRRFFTGAMSYGSISMESHSTLAVAMNRLGGKSNTGEGGEDAARSQVLENGDTMRSAIKQVASGRFGVTSYYLADADELQIKMAQGAKPGEGGELPGHKVSAEIGKTRHSTPGVGLISPPPHHDIYSIEDLKQLLYDLKCANPRARTSVKLVSEVGVGIVAAGVAKAGSENILVSGGDGGTGAAKLTSIKYAGLPWELGLAESHQTLVLNDLRGRVILQTDGQIRTGRDIAIACLLGAEEWGFATSPLIAMGCIYMRKCHLGTCPVGIATQDPELRKKFEGTPEHVINFFYYLANDLRKFMAKLGFRTINEMVGRTEKLKVRDDLRNTKNANIDLSPILTPAHTIRPGVATHCVRKQDHKLHIRVDNKLIDESELTLAKGLPVTIDCEVVNTDRSLGTTLSYRVSKTFGEQGLPHDTIHVNVTGSAGQSFGAFLASGVTLELEGDANDYIGKGLSGGRIIVYPPRESQFKAEDQIIAGNTAFFGATSGSAFIRGIAAERFAVRNSGAIIVTEGTGDHGCEYMSGGRVVVLGATGRNFASGMCGGIAYVLDMAQDFSEKVNRAQVELSQVTETEEIAFLRNLIEDHRHYTGSEVADNILNDFNRYLPRFVKVLPNDYKKVLEKEKKLAEEAKKKELSSFLKSIKEDPESDVTNGEAYKIKKGHVHHPNKGKNEPKVADVEDTIFNTEFEKKAPVKLDKLRGFMKYKRRNEKYRDAKARTKDWNEMTSRLTKEELKYETARCMDCGVPFCTSDTGCPISNVIPKWNELVFNDRWYDALQRLMMTNNFPEFTGRICPAPCNGACVLGINEDPVNIKSVECAIIDHGFEQGWIKPTPPAHRTGKTVAVIGSGPAGLAAADQLNKAGHLVTVYERSDRPGGLLMYGIPNMKLDKGIVKRRTDLLAAEGIEFICNTTVGEDITVSELKSQFDAVVFAVGSTIPRDLRIPGRELKNINFAMQLLHSNTKALLDDQLEDIRKNLAGKNVVVIGGGDTGNDCLGTSTRHGAKSVTNFELLPNPPNARPKDNPWPQWPRIFRVDYGHTEVATHYGKDPREYSILSKEFVGDEEGNVKGIKTVRVEWKRSDSGAWQMAEVPGSEEFFPAEVVLLSMGFLGPEADNLEVQKTKRGTITTVDPNVYKVDKDDNVFAAGDCRRGQSLVVWGIQEGRQCAREVDEYLMGSTRLPGNGSVEQRNYKLLEELAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEK5</accession>
    <name>A0A1D8PEK5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C109320CA</name>
        <name evidence="2" type="ordered locus">orf19.12256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723478.2">
        <property type="nucleotide sequence ID" value="XM_718385.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEK5"/>
    <dbReference type="GeneID" id="3634834"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109320CA"/>
    <dbReference type="CGD" id="CAL0000176411">
        <property type="gene designation" value="orf19.12256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09320C_A"/>
    <dbReference type="eggNOG" id="ENOG502T1UR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEK5"/>
    <dbReference type="OrthoDB" id="4097096at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08732">
        <property type="entry name" value="RGS-like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000176411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61419" checksum="12C6468104334123" modified="2017-01-18" version="1">MTLASSPDESVNALSSTSPPTITTSTSTASTLTNSSPYPVSPRTKNAMPSSIFTSLDQTIGSSTATNSTCSPITRPSTPLLPPLEDLVNDCFLHSMGQLEDEGKIKVVQDFTDYLTKQHTQENLNFLVDIYRYEYYYKLKFDQNNNEQEASTNNYVSNGTSNCNNNESELNSRYHSCCSLESLSNMRKTRSIQSVDLDPQNAFVSTIDDLDDFGNANENIWDNLKDKYTCSDDENDNKSQDQSVNNPNDEQDPDIILLNDEWKYIMNTYIKCDSPMEINISQTLFKQIVQESAFSRLHHPQTLTKASKEVLRMLNENGYVNFNSHMKKLLRKQSKSPTSSTPILSPSTSPLPYIGDSMSPSSLTSKTKPYNIPNNIQTHRASKSIVSSPGRSSTINHSNTESGSFFSKFSSLPKKTNKILNSANGNNSSGTDNSSTTSSSSSTASISVLLGHLKLGKDNNGNPTAASTSNLNGNHDKHVSSRSHKISHQHSVHRSHHHHTNHHIKRTGTFHGVSVNDPESSNSSDVGSDYRSLNASPVSINNESGGTSSLKFWSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PES3</accession>
    <name>A0A1D8PES3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Nuclear transport factor 2</fullName>
            <shortName evidence="3">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NTF2</name>
        <name evidence="5" type="ordered locus">CAALFM_C110100CA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330688.1">
        <property type="nucleotide sequence ID" value="XM_019475143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PES3"/>
    <dbReference type="SMR" id="A0A1D8PES3"/>
    <dbReference type="FunCoup" id="A0A1D8PES3">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PES3"/>
    <dbReference type="GeneID" id="30515039"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110100CA"/>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10100C_A"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PES3"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
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    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="124" mass="14193" checksum="B799D1ABA828A049" modified="2017-01-18" version="1">MSVDFNAVATEFCNFYYNQFDSDRSQLGNLYRNESMLTFETSQLQGARDIVEKLASLPFQKVAHRISTLDAQPASANGDILVMVTGELLIDEEQNAQRYSQVFHLIPDNGSYYVFNDIFRLNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PET4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ecm21p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ECM21</name>
        <name evidence="4" type="ordered locus">CAALFM_C110180CA</name>
        <name evidence="3" type="ordered locus">orf19.12352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723570.2">
        <property type="nucleotide sequence ID" value="XM_718477.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PET4"/>
    <dbReference type="FunCoup" id="A0A1D8PET4">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PET4"/>
    <dbReference type="GeneID" id="3634784"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110180CA"/>
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    </dbReference>
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    </dbReference>
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            <begin position="445"/>
            <end position="717"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="646"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="728" mass="81613" checksum="360384DFCC8B3323" modified="2017-01-18" version="1">MDNGHCYVRESTNNHHHLNTVVDNLRQRAGSFSFISHHHNHHQNSHDNYTVDPLTSNGARISRSRSRSKSVGHGEAISPAYFSKNKTKDLVKQETAHIISKKLLNMLQDLDLQNPIALKTISQGSESKFCKIYVSNTNNCIYLPAASSTSFTYEDDENGGVIIAEDRNDEMPTAVNNNTLSMDSINHSETDFSDSPPPPDLFSKMKSFHSPNYLTSKIDSECPIPHTFAVIVELTKDSLIIKDLHFQFQSLTTILWPTGDAYNRTHAKEKFTIGNMEWRTSLSDADYYINSSNSNDVKSKNLGPEDLINRTREYKLIDIEEPNNSSNSLSDDDMDINNITSPLSTSPTSSSTSTNSTSNSLGSDSYKAGLYVFLLPILLPEHIPASIVSINGSLAHTLSVECNKYTDKLNRKSKVSASYNLPMVRTPPNIGNSIADKPIYVNRIWNDAVHYIITFPRKYVTLGCEHMINVKLSPMVKDVVIKRIKFNVLERITYVSKNLSREYDYDSEDPYCIHPVSKENKVRERVVSLYELKTKAKQSSGGHLEAYKQEVMKCPENNLLFSCYEVENDNNNGNGNKNVKQKNKDQPMIATPLDINVSLPFLTTMSDSLIMTSAIEEEGSDSPHTSRRGSAVSMTDNNTTPSNNNPLSPFLGAVETNGASINEIGDHTLFPDSNFRHIEIKHRLQVTFRISKPDSDNKMHHYEVVIDTPIVLLSSKCQEDSPPPYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF30</accession>
    <name>A0A1D8PF30_CANAL</name>
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        <submittedName>
            <fullName evidence="5">Tubulin-binding prefolding complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C111110CA</name>
        <name evidence="4" type="ordered locus">orf19.9841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713910.2">
        <property type="nucleotide sequence ID" value="XM_708817.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PF30"/>
    <dbReference type="SMR" id="A0A1D8PF30"/>
    <dbReference type="FunCoup" id="A0A1D8PF30">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PF30"/>
    <dbReference type="GeneID" id="3644413"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111110CA"/>
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        <property type="gene designation" value="orf19.9841"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11110C_A"/>
    <dbReference type="eggNOG" id="KOG4098">
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    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016272">
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Tubulin-binding prefolding complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PFD2"/>
    </dbReference>
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        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000197543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="124" mass="14317" checksum="B44E7827B6C881DE" modified="2017-01-18" version="1">MSTTKPTATDEQKSQVLQQEYNRYQELIAELDSQLNTISSQLQEHLIVDQSLTSIAPEKREGRKCFKMIGGVLVEKSIDEVIKILNDEITQLKTEREKLNKELTENRKKLESWITTNKIKIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFL7</accession>
    <name>A0A1D8PFL7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">RPN1</name>
        <name evidence="9" type="ordered locus">CAALFM_C113300CA</name>
        <name evidence="8" type="ordered locus">orf19.12421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722167.2">
        <property type="nucleotide sequence ID" value="XM_717074.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFL7"/>
    <dbReference type="SMR" id="A0A1D8PFL7"/>
    <dbReference type="FunCoup" id="A0A1D8PFL7">
        <property type="interactions" value="1619"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFL7"/>
    <dbReference type="GeneID" id="3636147"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113300CA"/>
    <dbReference type="CGD" id="CAL0000177742">
        <property type="gene designation" value="RPN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13300C_A"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFL7"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="7">
        <location>
            <begin position="934"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000177742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="993" mass="109883" checksum="95B898E214D3FB89" modified="2017-01-18" version="1">MAPSQEQSKEQIQSQTSKDQQPTKSDKSKVQKEEELSEEDQHLKDELELLVERLNEPNQDRALYNKYLDALKTFIKESTTSMTAVPKPLKFLRPHYPSLTELYTNWSNQFSAKDVIVIKLADILSVLATTYSDEGNRDSLKYRLLASDDTISDWGHEYMRHLALEIGESFQENLGVDEELVNKLVKLALQIVPFFLKHNAEADAVDLLLEIECIDKLPQFVDENTFARVCLYVTSCVPYLAPPDDVSFLNTAYSIYLSHNQLTQALTLAIKLDDNELIKQVFDSTTDESLHKQLGFILSQQNSNFKYPGENPEVQECISNVKLAEYFQYLVKELNLLDPKVPEDVYKSHLENSKFGLGTSGSIDSAKQNLAASFVNGFLNLGFGNDKLVQTEEDNKSWIYRTKGSGMASTTASLGSIHQWNINEGLQVLDKYTYSEDSEVKAGALLGTGVVSANVHDEVDAAFALLQEYVHEPNKLYQTAAINGLGIAFAGSANEDVLNLLLPLVSDLDISLEISCLAALALGHIFVGTCHGDVTSTILQTLLERDYTQLTNKFIKFMSLGLGLLYMGRTEQAEDVLETIDAIEHPISKTLKVLVNICAFAGTGNVLQIQALLQMCTAKPKDQLEEEKKLEQSEEEQQQQQQNKDTKSNGEGGEEEEDVEMEDAESKNETSENTTASATSTTSSSKEKGDSSSSAAAAAAGDEKAQEGGDDKEDEEEIDEEEELYQGIAVLGLACIAMGEDIGQDMSLRHFGHLMHYGNSLIRRAVPLAMGLVSTSNPQMKVFETLSRYSHDPDLEVAQNSIYSMGLVGAGTNNARLAQLLRQLASYYIKSPDTLFMVRIAQGILHLGKGTLTLTPYNSERTILSKVSLASLLTIAIALLDPRSFILNDSTTETTHQLLYYLTPAVKPRMLVTVDEELKPIKVNVRVGQAVDVVGQAGKPKTITGWVTQSTPVLLNYGERAELENTDEWISLSSSLEGVVILKKNPEYMEIDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFL9</accession>
    <name>RL14_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL14</name>
        <name type="synonym">RPL14B</name>
        <name type="ordered locus">orf19.4931.1</name>
        <name type="ORF">CAALFM_C113050WA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330719.1">
        <property type="nucleotide sequence ID" value="XM_019475174.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="u=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="u=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="u=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="u=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="u=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="BH/u=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="8 9" key="2">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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            </authorList>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Thorstenson Y.R."/>
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        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
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        <property type="gene designation" value="orf19.9552"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
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        <property type="entry name" value="P4HA-like"/>
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    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="140"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000190230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="251" mass="29142" checksum="DF0BBD296E5FBD24" modified="2017-01-18" version="1">MHTFYLPFILSLSMPPKKKSSKTIYKFPQSFHDLPKSLSKNYYQPEPESIINDQIIIIKNFFNKDLCNELIKSFETQLNMETTPLIKSKEYAARFNDRSSMNDLLSANILWQYLQKILLDNPYNDEDLKEINQIFQDAVGLNPQLRVYRYTRGHHFGKHYDDSVICPIPPQGTKKGFTKWTLLIYLTGDEEFKGGGTIFYPEIKNIKPLNIHPNKGMALLHKHGDDCLKHEAEMVANGAKWVLRSDVVFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGB0</accession>
    <name>A0A1D8PGB0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C201220WA</name>
        <name evidence="6" type="ordered locus">orf19.9553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719452.2">
        <property type="nucleotide sequence ID" value="XM_714359.2"/>
    </dbReference>
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        <property type="interactions" value="1174"/>
    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C201220WA"/>
    <dbReference type="CGD" id="CAL0000193461">
        <property type="gene designation" value="orf19.9553"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01220W_A"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000193461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGV8</accession>
    <name>A0A1D8PGV8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C203210WA</name>
        <name evidence="5" type="ordered locus">orf19.909.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <sequence length="514" mass="57836" checksum="CF9B35765D70CB97" modified="2017-01-18" version="1">MNQTTETDSMRINLQRTYKDAINALNSLQSNFASIEATKKLGPSVNRNELSINEVHEFTKRLGYTPTDFNKLNIIHITGTKGKGSTCAFTESILKQYPISKIGLYTSPHLKSVRERIRINGQPINQEKFAKYFFEVWDKFTTTKSDPQEWPTLQPCDQVKPMYFKYLTILSFHVFLQEGVDTAIYEVGVGGTYDSTNIIDKPTVTGISALGIDHTFMLGDNIASITENKTGIFKKGVPAFVSKQSEYPETHELIEKRAKQLGVSSLEFVDTEDLPNVKLGLSGEFQKQNAALAIRIANSHLKTIGITQDLPEFNNNDGKIKKLSNEFIKGLENVDWPGRCQIINNNPTGITWYIDGAHTIESINASSTWFKQEQLKLEKPKRRALLFNQQGRENYAELLEKLFNVTYGTGSEPQIKFDDVIFTTNTTWSSGQFNSELISKNTSEDAVKKLEVQNNLSEVWGKLDGGVSKRHVFADIETAVNYLKDLGDEDLQVFVCGSLHLVGGFLVVLDNERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Saccharomycotina</taxon>
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            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
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    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        </source>
    </evidence>
    <sequence length="326" mass="36480" checksum="1106C80C17E64EB2" modified="2017-01-18" version="1">MRSLTYISISGWLNILLQVFGGCCSNVFVLEDLLYNNKSEYSLGTLVTFSQFLITSILSIPISTKGFIRPTVPVSRWIFPVVLYFLTSLLNNLVWQFDITVPMHIIFRSSGTVVTMLVGYFFGNKRYSKHQIVSSIFMTLGTIMATLPEGNSLSIEINIKFLTGILILTIASVISAFMGLYSELIYKQYGNQWHESLFYNHFLALPLFVFVSPTIYREFGVVLQSKQVTLGAFKFPRQLLSLTVNVLTQFICTKGVNMLAGETSALTVTVVLLVRKFVSLILSVIFYGSYMSTSGMIGSIIVFGSAAYYSISGISDRKIIEVKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIL8</accession>
    <name>A0A1D8PIL8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C210070WA</name>
        <name evidence="9" type="ordered locus">orf19.1775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714419.2">
        <property type="nucleotide sequence ID" value="XM_709326.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1D8PIL8">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIL8"/>
    <dbReference type="GeneID" id="3643946"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210070WA"/>
    <dbReference type="CGD" id="CAL0000195177">
        <property type="gene designation" value="orf19.1775"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10070W_A"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIL8"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="130"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="245"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="327"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000195177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="380" mass="42162" checksum="A51D67462160383A" modified="2017-01-18" version="1">MSKPKVLMALYSGGKHANEESRLLGTVENELGIRKLVEEHGYELITTADKEPSSNSDFDENLQDTEIIITTPFFPAYVTKERIAKAPELKLCITAGVGSDHYDLDALNERGIAVLEVTGSNVQSVAEHAIMTMLILLRNYXEGHAQATTKGTWDIAAVAKDEFDMEXKVFATIGXGRIGYRILERLVAFNPKKLLYYDYQPLPEETINKLNVASKLFNGVDNIVERVEKLEDLVSQADVVTINCPLYESSKGLFNKDLISKMKKGSYAINTARGALTDPQAIADAVNSGHIAYGGDVWPVQPAPKDMPWRTMHNPYGKDYGNAMTVHVSGTSLDAQARYANGVKQILTEYFNKTYSYRPQDVIIIDGDYATKAYGQRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIM4</accession>
    <name>A0A1D8PIM4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C210050WA</name>
        <name evidence="11" type="ordered locus">orf19.9344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714422.2">
        <property type="nucleotide sequence ID" value="XM_709329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIM4"/>
    <dbReference type="SMR" id="A0A1D8PIM4"/>
    <dbReference type="FunCoup" id="A0A1D8PIM4">
        <property type="interactions" value="1481"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIM4"/>
    <dbReference type="GeneID" id="3643949"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210050WA"/>
    <dbReference type="CGD" id="CAL0000182786">
        <property type="gene designation" value="orf19.9344"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10050W_A"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIM4"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJU0</accession>
    <name>A0A1D8PJU0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aap1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">AAP1</name>
        <name evidence="11" type="ordered locus">CAALFM_C303990CA</name>
        <name evidence="10" type="ordered locus">orf19.10328</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705914.2"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C303990CA"/>
    <dbReference type="CGD" id="CAL0000188193">
        <property type="gene designation" value="AAP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03990C_A"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="FAIAWNY"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:amino acid transmembrane transporter activity"/>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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        <property type="entry name" value="Amino_acid_permease_CS"/>
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        <property type="entry name" value="APC_YAT"/>
    </dbReference>
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        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="120"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000188193"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="637" mass="70561" checksum="8A9E38312DE16C07" modified="2017-01-18" version="1">MISIDNANTGRRSTLSSTISSFDADRSLYNSTTSSTGSTSSSPYPRSYHPRDLLNSFIDSFKEFDYSTLPPVYNNITDQESQLQLNPANPNFDYSHFTQLERDALITASSPLSKRLKTRHLTWISLGASIGSGLLISSGSSLAHAGPLGLLIVWIFVGSVIFATMSSLAELATAFPVSGSFTTYVTLFVDKSISFAIAWNYALQWLVTFPLQLVAASLAIEYWTIKIHPAIFVTIFYVCIVFINLFGVYGYAEIEMVVSIIKVIAVIGFNILAIIIVTGGVPGQPYIGAKNWQGPQGGLFNTIEPFKQMCYIVSNVAFAYGGVELFGLAAVETASPKKSINRARKQIFYRLMVFYILSIVMIGFAVSYKTPELQDSGAFGTDINASPFVIAIKQAKIKALPSIMNGAVILTVLSVGNASVYASTRVLCAIGALQQGPKFLSFIDRSGRPMGCLIVQFAFGLLAYLICIPGKNVPAQIFDWLLSLSGLSALFTYISINVCQLRFNCALKHRARIPKDELLYVSPLWCSWYGIFAIIAILALQFWAALFPPGAGKADVESFFKIYLGGPILFLCWLGHKLYSYWYLNVPLTKFWLTVDEIDIDTGRRQIDLETIKQEIAEEKIVMESKPWWYRLYKTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJU2</accession>
    <name>A0A1D8PJU2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C304040WA</name>
        <name evidence="1" type="ordered locus">orf19.10322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="288" mass="32817" checksum="323ED0B1ADE892E3" modified="2017-01-18" version="1">MPSQAYNYNINKYSVYKSDTNSWYHYPQRTNLSVTFVYNGDQADQIDVIVHWKGSNLDNFNLFNTNKCKTTVLCRKPCIGVKQVNNNGIVFKRFQISLINEVTSNFDTCCTMLRGFNFQIKIKDNMNETKAQSQQNNGNIQSNDSQIVQPIQSISDTQMYPLIQPASQIPIQLPSQNMASCFSSFSTQPSQPPSQIIEPQIYQLFSQPGHVMHQGKIPETTNKVVSTNLTIDATTQTLPRKLQSVFLDDINELKKISNSSLRSVIKTSLQRKDFLDLIDRLDKIITDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK15</accession>
    <name>A0A1D8PK15_CANAL</name>
    <protein>
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            <fullName evidence="13">Cdr11p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">CDR11</name>
        <name evidence="13" type="ordered locus">CAALFM_C304070CA</name>
        <name evidence="12" type="ordered locus">orf19.8533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710998.2">
        <property type="nucleotide sequence ID" value="XM_705906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PK15"/>
    <dbReference type="SMR" id="A0A1D8PK15"/>
    <dbReference type="FunCoup" id="A0A1D8PK15">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PK15"/>
    <dbReference type="GeneID" id="3647389"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304070CA"/>
    <dbReference type="CGD" id="CAL0000188523">
        <property type="gene designation" value="CDR11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04070C_A"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PK15"/>
    <dbReference type="OMA" id="WHDVCYE"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter CDR4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1269"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1313"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1351"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1476"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="142"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="854"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000188523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1512" mass="171465" checksum="A157D668F68DD488" modified="2017-01-18" version="1">MVNIQPQNATESAVNQSCEPITTPASSEYEGFDHNEVRQLAKILTNDNDDSAKSSLVRQLSNMSNVPGVNPCDANNLPPQLNPNCDQFDSKLWIKNLKKLYESDPEYWQHSKLGVAYTNLRVYGIANDVDYQPTVTNLLWKLGGEAFRKYFRKNDKTQYFDILKPMDAIMRPGEPTVVLGRPGAGCSTLLKTIAVNTYGFHVGKESKICYDGLTAHDIEKHFRGEVIYSAETEVHIPHMTVGDTLEFAARLRTPQNRGDNIDRETYAKRMADAYMATYGISHTRNTKVGNDIVRGVSGGERKRVSIAEVSLSGAKIQCWDNSTRGLDSATALEFIRALRTSAKILDCTPVVAIYQCSQDAYDLFDNVSVLYEGYQIFFGKASKAKEYFEKMGWKCQPRQTTADFLTSLTNPAERQTLPGFEDRVPRTPQEFESYWKRSPEYSELMGQIDGYFVDCETLNTKEVFHQAHVAKQSNHIRPSSPYRVSFFMQIKYLVGRNFKRLKGDPSLAIFRVCGQIIMGLILSSVFYNLQSTTESFYYRGAALFYAVLFNAFSSLLEVMTMYEARPVVEKHRKFALYCPSADALASIISELPVKLASSISFNLVFYFMVNLRRDPGRFFFYWLMNIWATLVMSHFFRTIGAVTTSLAGAMTPSTILLLAMVIYTGFVIPKPSMLGWAKWITYINPVSYIFESIMVNEFYDRQFECSQYIPSGPGYENVDSKNKVCTAVGSVPGEPFVNGTNYLKYAYEYYNSHKWRNLGIAIAFAVVFLGVYIWLTEYNKGAMQKGEIVLFLKSGLKKHKRKNQKATGTALEDIETGKFSNDKLIYPSDIEEEEGGATDKRLNLSGTDNRPEIFFWKDLTYQIRIKKEDRIILDHVDGWVVPGQITALMGATGAGKTTLLNCLSGRLTVGVVTEGARLVNGHSLDSSFPRSIGYVQQQDLHLPTSTVREAFRFSAYLRQPNYVSKQEKDEYVEYIIDLLDMKTYADAIVGVAGEGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLANHGQAILCTIHQPSALIMAEFDRLLFLQKGGQTVYFGELGQNCQTMINYFERNGADPCPKEANPAEWMLEVVGAAPGSHAKQDYFDVWRNSNEYQVVKDEISRMEIELSKLSPLPSSSNGRDEKESRLTYACPLWKQYLLVTWRTIVEDWRTPGYIYSKLFLVVSSSLFNGFSFFKADKTIQGLQNQMFAIFMSFIPFNTLLQQMLPFYVKQRDLFEVRESPARTFSWFAFIAAQITSEIPFQIVLGTIAYFCWYYPVGLYVNAEPTNQVVSRGVLTWLLQVSFYVYVSTMGHLCNSFLELPDAAANLANLLFSLCLMFCGVLAGPSQLPRFWIFMYRCNPFTYLIQAILSTGLANTRVVCSEHEYVVIEPPAGQTCQEYMSVFITMHGGYLLQSNNGAAESGTCSYCTMDETNTFLKSVNALFSQRWRNYGIFNAFIVINVALAIFFYWLARVPKGNRESRIKHRKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKM5</accession>
    <name>A0A1D8PKM5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">OPI3</name>
        <name evidence="20" type="ordered locus">CAALFM_C306570CA</name>
        <name evidence="19" type="ordered locus">orf19.7446</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716107.1">
        <property type="nucleotide sequence ID" value="XM_711014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKM5"/>
    <dbReference type="FunCoup" id="A0A1D8PKM5">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKM5"/>
    <dbReference type="GeneID" id="3642277"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306570CA"/>
    <dbReference type="CGD" id="CAL0000189933">
        <property type="gene designation" value="OPI3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06570C_A"/>
    <dbReference type="eggNOG" id="KOG4142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKM5"/>
    <dbReference type="OMA" id="PTFWNIA"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="PHI-base" id="PHI:8896"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000189933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW28663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="225" mass="25425" checksum="0D179A56400976B7" modified="2017-01-18" version="1">MSSIAQELSTLPSDLIYLAQNFPQYIDLKGKLFGNDIIQNQLIYSIICISFNPIFWNIVARLEYKTHFLTKICFNSAKLGCYVLAITIFSLGIYRDHVYYQALETQPTYQPLIDSIIIKSLAIALFAFGNVLVISSMYALGVTGTYLGDYFGILMDHRVTGFPFNINDNPMYNGSSLCFLATALWYGKPAGIAVAIYVFVMYKIALLFEEPFTAKIYANRIDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKW5</accession>
    <name>A0A1D8PKW5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 18, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C307940WA</name>
        <name evidence="4" type="ordered locus">orf19.6189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM18/AIM46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710945.2">
        <property type="nucleotide sequence ID" value="XM_705853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKW5"/>
    <dbReference type="SMR" id="A0A1D8PKW5"/>
    <dbReference type="FunCoup" id="A0A1D8PKW5">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKW5"/>
    <dbReference type="GeneID" id="3647453"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307940WA"/>
    <dbReference type="CGD" id="CAL0000197659">
        <property type="gene designation" value="orf19.6189"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07940W_A"/>
    <dbReference type="eggNOG" id="ENOG502RGD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKW5"/>
    <dbReference type="OMA" id="RIIPTRS"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
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        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="52"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000197659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="237" mass="26444" checksum="B678DE0C4D388538" modified="2017-01-18" version="1">MFRYVRSAFIVSAVAATPLFHPKILSEVKQVVVDSSLNPFPTEIPKGLFHNDFQLLGHGVRSVTFISFKVYGVGIYIAKKDIPKASSVLMGMADKLKDPQESAQVIEKLLDSDVKFLVRLAPVRNTDFNHLKDGLIKSILAHPKSKEMKTELGVGLDELRQAFTRRGTVPKNHLLYLEMLDGGKMELSYVNPEKKPYKMGVVDSPLVSRQLMLQYLSGAKPLSPSLRDSCIEGFINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKZ4</accession>
    <name>A0A1D8PKZ4_CANAL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C400230WA</name>
        <name evidence="1" type="ordered locus">orf19.13093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713329.1">
        <property type="nucleotide sequence ID" value="XM_708236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKZ4"/>
    <dbReference type="SMR" id="A0A1D8PKZ4"/>
    <dbReference type="GeneID" id="3645034"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400230WA"/>
    <dbReference type="CGD" id="CAL0000175557">
        <property type="gene designation" value="orf19.13093"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00230W_A"/>
    <dbReference type="eggNOG" id="ENOG502RS1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKZ4"/>
    <dbReference type="OMA" id="WLILHEN"/>
    <dbReference type="OrthoDB" id="10008801at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000175557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW28816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="202" mass="23524" checksum="007919CEFC5AE99E" modified="2017-01-18" version="1">MINSGNGCCCCFFLAGRLSYFFFRCWQKWTEKKIEKKVESCGRVSCPNQALLEFWLILHENSEKFLHSPFSYKYRNMFRIVARAPRILPYRRFTTTPSLRFFDKGPTAEEQAQALEKVSKVVAENPELYKLMVEFKQLLEKKGFETGAKPSMTQMFKLLADKDIREHGAKFKHFLETTDTGLTQNEIATVSGAFLFKNKDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLE7</accession>
    <name>A0A1D8PLE7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C401990WA</name>
        <name evidence="6" type="ordered locus">orf19.4593.1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330910.1">
        <property type="nucleotide sequence ID" value="XM_019475365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLE7"/>
    <dbReference type="SMR" id="A0A1D8PLE7"/>
    <dbReference type="FunCoup" id="A0A1D8PLE7">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLE7"/>
    <dbReference type="GeneID" id="30515246"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401990WA"/>
    <dbReference type="CGD" id="CAL0000193191">
        <property type="gene designation" value="orf19.4593.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01990W_A"/>
    <dbReference type="eggNOG" id="KOG4620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLE7"/>
    <dbReference type="OMA" id="VEMYSSP"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000193191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="78" mass="9620" checksum="61D3530B10D08E5A" modified="2017-01-18" version="1">MARLSGLQRDVLQLYRKCIRMVKTKPTDTHEHWRNFIHEEFAKYQHLPKKQFNTIEYLIRNGHRKLEMYSNPQLKDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM53</accession>
    <name>A0A1D8PM53_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C404800WA</name>
        <name evidence="9" type="ordered locus">orf19.11280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717204.2">
        <property type="nucleotide sequence ID" value="XM_712111.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM53"/>
    <dbReference type="FunCoup" id="A0A1D8PM53">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM53"/>
    <dbReference type="GeneID" id="3641113"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404800WA"/>
    <dbReference type="CGD" id="CAL0000195123">
        <property type="gene designation" value="orf19.11280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04800W_A"/>
    <dbReference type="eggNOG" id="KOG1792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM53"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045064">
        <property type="entry name" value="Reticulon-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994:SF193">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="56"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000195123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="366" mass="38751" checksum="4D013A5F628652F2" modified="2017-01-18" version="1">MSTSIPTESPLTTNNTTTTTAADISTTSGTTATPAQASVPTSTSSIADTHHSSCSTTDFLTWKNPIKTGKVFGSLVFGLIVLKTVNLFNIFFHLAYIGLLISAAAEYSGKLITGKGFLANFKPTGKLYAKRFNDEVLPELANFNVHLEESFNKIVYSHDIETTLKAAGISYILYKLTSWFSLYTLIFIFVVLIFTVPVIYKTYKKEIDAAVADITKTIKTKSAEFTEKAHKAAGPHIDTLIKKTGPIGSFIQSKLPVRTAGSTVGDSKATSYGTDADKSIAGTTSATGTSSATANSTTVPVSVPAATSATSAEPISTGHSTGASQFPSAPTSGLHPSTVEDVIKQASEEADEFADTTQESFKPTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM62</accession>
    <name>A0A1D8PM62_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease III</fullName>
            <ecNumber evidence="3">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">DCR1</name>
        <name evidence="13" type="ordered locus">CAALFM_C404830WA</name>
        <name evidence="12" type="ordered locus">orf19.11277</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="3"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717201.1">
        <property type="nucleotide sequence ID" value="XM_712108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM62"/>
    <dbReference type="SMR" id="A0A1D8PM62"/>
    <dbReference type="FunCoup" id="A0A1D8PM62">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM62"/>
    <dbReference type="GeneID" id="3641164"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404830WA"/>
    <dbReference type="CGD" id="CAL0000189883">
        <property type="gene designation" value="DCR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04830W_A"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM62"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034963">
        <property type="term" value="P:box C/D sno(s)RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035196">
        <property type="term" value="P:miRNA processing"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19876">
        <property type="entry name" value="DSRM_RNT1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000001">
        <property type="entry name" value="Ribonuclease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040540">
        <property type="entry name" value="RNase_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
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            <dbReference type="PROSITE" id="PS50142"/>
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            <dbReference type="CGD" id="CAL0000189883"/>
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        <source>
            <dbReference type="EMBL" id="AOW29226.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="611" mass="68787" checksum="5F8486A109151581" modified="2017-01-18" version="1">MSSFSQKNLAAQNIAETANKGFMSYINNWTSTSQQEDNKVISSNLDDPLSVSDIDSDTSMSSNNSSKNHHSSKRSSPAPVPSTVTKKTKITDKYLKELSAYHEPVFDKPPPTTIGILDMNQLEHSTKTMQKCVSSILEKAPNCNQLQYLIESDEIDNGIRLELQDNPLIDTASKLKSLHEIGKLPILDQIINDEVKISDDDLKKLKKIPAKSNSVKVNSPRDVVPEIASTGVHHDMPPLPPINDPKLFERVFIHKSTVNNKQYLEANHLLHSHNERLEFYGDSILNNLATLIIFKEFPDSTEGDLSKIRSKLVSNKTLIKIAFQYGFDKKLRSRISDDVLKTGDKKIFADVFEAYIGALAMERGFDLEDVKEWLAKVYAPLIHELKIEYIEEPIDREAKSKLYGLIGQDDLHPVYNTLQMGDGIHNKFIVQCTINGEELGRGTANNLKEAGLRAAMAGLNNNEVLKKYFVARQQIERPIKLQRLERENAKKREVAERLEQERNNLPSTPSSPIRTSMFPISVNENEPLDIDAKNKLYGILGRKIGDKPAYLTSQINGNLFKVVLCIRGITICETTDPSKKKAMARAAQTLLENESAMREICKDFRTKDSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMA9</accession>
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        <recommendedName>
            <fullName evidence="9">Protein MAK11</fullName>
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        <name evidence="7" type="ordered locus">CAALFM_C405330CA</name>
        <name evidence="6" type="ordered locus">orf19.9357</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_706347.2"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PML3</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="6" type="ordered locus">orf19.10408</name>
    </gene>
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        <lineage>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
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                <person name="Dungan J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="10 11" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="A0A1D8PMR5"/>
    <dbReference type="FunCoup" id="A0A1D8PMR5">
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    <dbReference type="STRING" id="237561.A0A1D8PMR5"/>
    <dbReference type="GeneID" id="3642903"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407100CA"/>
    <dbReference type="CGD" id="CAL0000181172">
        <property type="gene designation" value="BRR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07100C_A"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMR5"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000388">
        <property type="term" value="P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004219">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004220">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="383"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="574"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000181172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1987" mass="227193" checksum="9BBBC0BB48453890" modified="2017-01-18" version="1">MSNNVIRQQRDRNHEEEIPASSMTGRISKSDMRSNYKSSPAPAQLNKPPRKEPESEPVDDQLYELFVTKIRSYLPDSSHEVIQSASEVASEQLSNRDISVPEKRKELEELLNASISDDDLHELINLSNSIESAKQNHQQGNGDDEFVAIDFNSSDDEEQAIEAEIEVEDESDKETDTEEPTSNEHPKAYDWHWLQQISEFKHYGSQVFDLLADKDLDSLQLDSKLNELLDSKGMDFIVKCIEHRWRIVFSKRLQTENKEPVIKEMEELGLHSLINELHRKRSLDDETSNPLKRQKKVKRVPQKISLDRIVFSTSVENARVTLPEGTIHEVKKSYDTITVPAPAQSLSDNDELLPISTLPDWAQEAFPKTETTTFNRIQSKIYNQAFETDNNLLICAPTGAGKTNVAMLTILRTIENFRNNGHIQLKNFKIVYIAPLKALVQEQMREFQRRLTSVYGVVVNELTGDSSLSKQQIAETQIIVTTPEKWDIITRKDPSYVKLVKLMIIDEIHLLHDERGPVLESLVSRAIRKSETTGSDIRIVGLSATLPNYADVAKFIRAKPEGLFYFDASYRPCPLEQVYIGVKEQKAIKRIAAMNEACYDRMHQSLQDRHQLIIFVHSRKETFTTAKYLMEKLDIDIVEQEGVKEILKQEGESMSNPKLKEVIPRGFGIHHAGLTKKDRGVVEDLFAQGHLRVLVSTATLAWGVNLPAHTVIIKGTETYSPESGAWVQLSPQDILQMLGRAGRPRYDKNGEGIIITSQDEVQYYLAILNQQLPIESQLIHKLVDNINAEIVAGSITTIEEGIEWLTYTYFFVRMLQSPALYGVEATYDFTNDPTLYNRRADLIYTAFCILHENKLVVYNAALGSVASTELGKIASHFYINFETINLYGKMLKPWHSETDILSVFSNSGEFKYVPVRQEERLEISKLMEKCPIPIKEQPNEPLAKINILLQTFISRLSLEGYALIADMIYITQSAGRLLRALYEIALLQKWSSLAKSILNLCKMVDKRLWLNNSPLRQFGDVVPHQIIRASEMSHLPWIRYFHLNPDELAVALNLKGNAQIAKQYIDSFPKVSIQYMVQPITEQFLRIQVEVIPEWSWISAIHGSQEIFNVFLEGCDGNKLLHSEQFIVKRKNINKPHILEFFVSFVAPPLPNYILSFVSEKWVHCTWKSSILLSNVISPKVSPHYLDNNVDLVPTETVGDLFPFTHFNKLQSSTFDTVYNSENNVFIGSSKGDGKTVLAELAILNHWNNKKGRIVYINPCQELVDKLFKKWSTFFSSYEKEINVLSGNLREDSASVNQSHLILATPEQFNCLSKRWKTRKAFRSIDLFIWDDLHLVGSDVHYEMLVTRVRMLTSQWDDYKLRIVALSSPVLNSRDIAEWIGVAKSEMFNFAPHSRENRITEIKLSVESSDNTVKIYKDLAKVNSGLRNTLIFAPSYIHAFEMAHSMVENNQAQEWRSVDLLKLEKYISKIQNPLLKNLLPKGIAVFYSGMARVDRLIVERLFESKSIGVLFCTMDTSKFAPTANNVFVAGTRVYDGHEHRFLDYPLNDLYEMVGCCQDGGVVHIYTTSQMVEFYSSFLNSGLAVESLLSNSLHEFFMDAVANGIIKQRQNCIDVLTFTFFYRRLLKNPSFYDLKEVSNSGISTYLSELIESVFDDFNKEEFIEEEDEGDTISPLNKIVIASHYNSTFETVSNLSKLSNKSKLKDIFHALTNATEFSDLPVREGEDALLIKLQTKLPIKYSQDDYESPFFKAFILLQAHISRISIPFDLRQDQKSVLTRVLQILNAAIDILSSDGSLNVLLAMDLSQMIVQAVWSSDNPLRQVPRFTNEILARCTQHNVETVYDIMSLEDEERNEILQLPDQELNEVASFVNSYPNIELSYEMKGGVTSNESKFVTVTIDRDEEIESLEVVKNENFPVTKQENWWIVVGDSKTRHLYGIKKVNIQKISQSFEIEFTIPNKGKHELTIYLICDSYLDADKEMEFVIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMT1</accession>
    <name>A0A1D8PMT1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tlo10p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">TLO10</name>
        <name evidence="3" type="ordered locus">CAALFM_C407250CA</name>
        <name evidence="2" type="ordered locus">orf19.10586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715384.2">
        <property type="nucleotide sequence ID" value="XM_710291.2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMT1"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PMT1"/>
    <dbReference type="GeneID" id="3642943"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407250CA"/>
    <dbReference type="CGD" id="CAL0000201622">
        <property type="gene designation" value="TLO10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07250C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PMT1"/>
    <dbReference type="OrthoDB" id="4092858at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021017">
        <property type="entry name" value="Mediator_Med2_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11214">
        <property type="entry name" value="Med2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="218" mass="24894" checksum="EECF8C466F83A8C8" modified="2017-01-18" version="1" fragment="single">MPENLQTRLHNSLDEILKSSGYIFEXIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKXDELKVKEEAARKKREEEAKKAEEAKKAEEAKKAEEAKKAETAPQKFDNFDDFIGFDINDNTNDEDXLSNMDYEDLKLDDKVPATTDNNLDMNNILENDESILDGLNMTLLDNGDHVNEEFDVDSFLNQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PND6</accession>
    <name>A0A1D8PND6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(32) synthase</fullName>
            <ecNumber evidence="3">5.4.99.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RIB2</name>
        <name evidence="8" type="ordered locus">CAALFM_C501940WA</name>
        <name evidence="7" type="ordered locus">orf19.10687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(32) in tRNA = pseudouridine(32) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10108"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.28" evidence="3"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714595.2">
        <property type="nucleotide sequence ID" value="XM_709502.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PND6"/>
    <dbReference type="SMR" id="A0A1D8PND6"/>
    <dbReference type="FunCoup" id="A0A1D8PND6">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PND6"/>
    <dbReference type="GeneID" id="3643740"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501940WA"/>
    <dbReference type="CGD" id="CAL0000193029">
        <property type="gene designation" value="RIB2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01940W_A"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PND6"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000061">
        <property type="entry name" value="DRAP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000017">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="6">
        <location>
            <begin position="435"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000193029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="589" mass="66994" checksum="D9052F92C86F29A3" modified="2017-01-18" version="1">MSIYKSGWVSPLKALETLSLTLSRGMKRAASPRAEQPPHSKKVVDAKGFRVRQQNIDKHKITSESTATQKSIHEEETEGANYVIEGRLRRVTPYFYTYLTYCKLRWQDRKLIDVFIDEFRDRTPDAYRKAVEEGLVKVNSQVANLETILRNGDLISHRSYRREPPVSSRDIKIVFEDDDLLVIDKPGGIPVHPTGRYRYNTVTKIFEHEKGKIVHPCNRLDRLTSGLMFLGKSSKGANNMMSQIRDRNVTKEYIARVKGEFPIERIIVDKPLSTKSPKLTLNVVDMEDGKDAKTEFQRVSYDPITNTSVVKCHPLTGRTHQIRVHLQFLGYPIANDPIYSSEFVWGKNLGENGEADLDQVMERLDLIGKSRAATSWIHPEGDGEVALDEICPITGLPLYSDPGSNDLDLWLHAYKYEADDKSWSYKTEYPEWALEPSRKFMKMAIEEAEKCGETQTQFNVGCVLVHNGQVISTGHSRELPGNTHAEQCALEKYFSKNGGEREVPAGTEIFTSMEPCSLRLSGNLPCVDRILQTKNIKTCFVGVLEPDIFVKNNSSYKKLLDHGVEYIHIPGYEETCLEIAKRGHEHIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNF8</accession>
    <name>A0A1D8PNF8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">SST2</name>
        <name evidence="5" type="ordered locus">CAALFM_C502160WA</name>
        <name evidence="4" type="ordered locus">orf19.11698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720533.2">
        <property type="nucleotide sequence ID" value="XM_715440.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNF8"/>
    <dbReference type="FunCoup" id="A0A1D8PNF8">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNF8"/>
    <dbReference type="GeneID" id="3637754"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502160WA"/>
    <dbReference type="CGD" id="CAL0000199031">
        <property type="gene designation" value="SST2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02160W_A"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNF8"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
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    </evidence>
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        <source>
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    <sequence length="675" mass="76748" checksum="2046BEDFEDFDCB40" modified="2017-01-18" version="1">MDSIITINMPRDNMELDYDCQKHTKGSILLASITPQNTKLLTELGCSPSKTSILHEATHHKFSRTSSGRIFEKDIKDIFSLLIISLRLERDGLTNYLFNSPPIIKLHKPLRKSYPYSFSLESAIEKMKDLQLDVESVNTVTCISYSFKSEVSLALIEQFYKARLLHSPADRTRSGAKSNVALQPTPKGIAIVQEFCERIGMEREEFPEVLLAHDFNTMELFNFDRDTRSDRILYSEYLLYLLFNLMMGPEPNVWTPSNTQDALPSLNFSDSESFDKLYKVFSNSQDAKNAKQNNDDSSDVEGFSFTSYRHFSKTHQSSETHSVTDSKEMATSPFHHRYFTNPESDAHSQYYVSSVGVRLLKDKIVLVGPNKSVTVDYCISGKAIYQWILDCTDIINPNHAHEIARLLVKHNLIKPVSFSSSLSFSRDAFYQLSTLGLALSSWDFFDRNLQDSSSLQPGTKILRLASNVTLQNILNDPGMRLQFRKHLIKDHCVENLEAYIQLMQFEETYKAWEDLSDIIDNQNHSCIPVKSSDVNIHLKDLQVTCMSFAFQIFHTYLSIDSPKIVNIDFRLRSKITTLMIGDSGARDNGDNESIIYLQTPTEDFALGSSVSEEAGGSTPRCHDHDELSAPANNFRKIANSLLQIKLQIYHLMEVDSIPKFLETLGVTSNRIITTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="3">Belongs to the PIGU family.</text>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="482" mass="55466" checksum="9D9ECD2D0854DF56" modified="2017-01-18" version="1">MLQIDKQTRRVFIIGGLIRFLLPTIIFPQLTSILDSSILLSTPITSFKSIQESIFYFLYNIELYNGGVNHTPPILIVLLSFLGNINTSVNGWNKIGYDLLYTVIDLIIAYKIIIINRWYNNYRQQKRNTNNKKKEGVEEEEEEEGTSGKFDDYLIGCFYLFNPLIILTNLSHSSIIFSWIFIMESIIQIVQYENIARSMISLAIASYLSFSPIYLLPSILALGHVIIRDKAISAKQQQEKKEGEEDKEQTNVKDLIVKLYVEGLAIFIICVILLIMISFIITASWQFLDNVYLTIILFKNPIPNIGLWWYIFIEMFENYTSFYLIVFNVYTWIFILPFTIRFFQYKNNKITSLLGDSFLAVILCLCWISFIKPYPILGDLGIVLSLLPILNDTIVQYCKLKYITGMTLIIGLLLAPIFYYIWIVLGTGNANFFYSITLIWGAIHGLILMDLIWTKLTLDYYNDNGIDINGEGGSLGLSLAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNU1</accession>
    <name>A0A1D8PNU1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pga56p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">PGA56</name>
        <name evidence="4" type="ordered locus">CAALFM_C503900WA</name>
        <name evidence="3" type="ordered locus">orf19.1105.2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330973.1">
        <property type="nucleotide sequence ID" value="XM_019475428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNU1"/>
    <dbReference type="STRING" id="237561.A0A1D8PNU1"/>
    <dbReference type="GeneID" id="30515313"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503900WA"/>
    <dbReference type="CGD" id="CAL0000180220">
        <property type="gene designation" value="PGA56"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03900W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PNU1"/>
    <dbReference type="OMA" id="IENKHYP"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111190" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
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                <person name="Dungan J."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Dungan J."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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                <person name="Dungan J."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000180566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="113" mass="13201" checksum="5DDB59D187F50A1B" modified="2017-01-18" version="1">MLRREATTIRLSPEDILEYDDSVAQQQKQKQELQQGQEQSIPQQNPSDFSPPNILQEQINNSSHSIIPDFKEESGSIYQRSRVSQQQQQQQSQSHHHQQQSRDERIGIQRNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">orf19.13076</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_714098.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ65"/>
    <dbReference type="STRING" id="237561.A0A1D8PQ65"/>
    <dbReference type="GeneID" id="3639235"/>
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    <dbReference type="eggNOG" id="ENOG502QU9H">
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    <dbReference type="InParanoid" id="A0A1D8PQ65"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000185504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="732" mass="84966" checksum="19E5494F3F938D8C" modified="2017-01-18" version="1">MSSNEEIINLLGRLNQNKNKNKTDDDSADNETTLNQLANLTKNGISEPLIMIILDKIFNDTLKITDKNKLLDECLIPNHDLSIDVFFKIISIIGVSRVYFKGNRKFKSKQLSISLQLKLLQWMIDNFQFLENTFCKSGSIVLTLLVKSLDYEFSRGPISQLIILVLNSSVSKSNQIITFYNQEIYHTINILKSNHIQTVVNLYNKFPLDIYLEELLAYFRVINPDLDYMIYSPENFPLLNKLNCNLNQVYRWKDSDELTATTITITTTTTTKSNKRQKTTITSKPDTLTHNIEVLDQINKINPYKLVRTAFDNEKEAQLLTILFQTGNNRFINKVDKYIGAILTTFTNSEKELQSFLQQVSHLYKISDGTIILPSIENFILDNNNNNSLSVGKFCQQFDYRSKLIKYLHNVDPMRLVTMIHHNASILKQIYYDTNNGSYETNSNFNYESCHDYVKNILYLLNLWIFENQDDIIISRINLLLPELYKFIKYCKHIQEQLTNQVVEFFINLPSSLFNQLELKTIIIPRSLTYSCLLSCDPLVVSNITQHISNCKSHDYTNSTHYRDLQNSYIMDTINFLWKERFLKQDTNLTNISSNKGFFLHPDFENKLNSLHTFDCSYYLSSSPSTIGEFFYNPAFSYIVTKIIWDIEDNHNGINTRHEGPISRESLIRLRNDSDKIWLSLSFDELKLSILQNLEIKKFNGIADLLFNSLKSLADKRSLDKNNESTNSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQI6</accession>
    <name>A0A1D8PQI6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">FRP2</name>
        <name evidence="18" type="ordered locus">CAALFM_C700100WA</name>
        <name evidence="17" type="ordered locus">orf19.7112</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720403.1">
        <property type="nucleotide sequence ID" value="XM_715310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQI6"/>
    <dbReference type="SMR" id="A0A1D8PQI6"/>
    <dbReference type="STRING" id="237561.A0A1D8PQI6"/>
    <dbReference type="GeneID" id="3638008"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700100WA"/>
    <dbReference type="CGD" id="CAL0000197893">
        <property type="gene designation" value="FRP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00100W_A"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQI6"/>
    <dbReference type="OMA" id="FDSVAFF"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140420">
        <property type="term" value="P:heme import into cell"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000119">
        <property type="entry name" value="Ferric reductase transmembrane component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="271"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="592" mass="68247" checksum="69649AE8FC18A699" modified="2017-01-18" version="1">MDEELQKHLEISRNTKYQWIACIFSLVIFLANGIVFYWIPRLLRDKRFVKTNRFKPYFAFVDIWQTINTPFSIKVGKKTHYFKPSLLALGACFILLNGKLCYIETDDLDYKPRIFIIGKRCARIALGQMPAMFLSVTKGDFITALTGLTYERAAFFHAWFATLMFSMMTAHVGIIGFYWAHPNYDIAPKYPKNVYGIIGYACFVFLVFGNVALIRRYAFEFLMVNHRVHSFIMLLMAFLHNDRAKAMVILAIHLLVLDKVLGRIYGIVHSLKSPTKGLSEFEILDDETLRVSIPVKTSKTDPTPWYRLFLFKYGTWLAGSHVYLNVRKVDFFQHHPFAVASLPESGKITLVIKKRNGFTKKLYDKVKTMRDEQLDSETSETDPNIVKLKAAFRGPSSGKFQPLITFDSVAFLAQDYGASFVLPLCLDLLQTIEKKEVAKNYLGRPAHPYLKVYWSVKRLNNIYWYEDLVRKLLPFINSGKLTMNVFVQESVELEATKSVSTKKLDIVSVTSDPSSITNSEIKFIYEEPMEVSQVIQSHISSMHFPEEKAFKSLAIMSCGNDNFGSQVESESQKYRWVKDAPNIYFYNESYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQJ5</accession>
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        <name evidence="11" type="ordered locus">orf19.7094</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQJ5"/>
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    <dbReference type="STRING" id="237561.A0A1D8PQJ5"/>
    <dbReference type="GeneID" id="3638048"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700280WA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C7_00280W_A"/>
    <dbReference type="eggNOG" id="KOG0254">
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        <property type="component" value="Chromosome 7"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="400"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000179365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="526" mass="57527" checksum="596D03D979E43BD0" modified="2017-01-18" version="1">MSANIQALMKSYVNFDEHTSGSAARGILIGMFAAFGGFLFGYDTGTISGVLSMDYVKARFPNNKTDFTSGESSLIVSILSVGTFVGSLIAPLFSDRIGRRWTLILSTLIVFNLGVLLQTVATEKKLLIAGRAIAGTGVGLISSVIPNYISETTPKWARGAVTASYQWMITWGLLIAACANKGSQGRKDSGSYRIPIGIQFLWALILGIGFLFLPETPRYWVSKSEETKAKDSLRRIRNLPVDHPDLVSEYDDIKANFDFESKYATSSWTQVFKNVNKQHHRLFTGVAIQALQQLTGINFIFYYGTQFFKRSGIEDPFLIQLATNIVNVGMTVPGIILVETWGRRPLLMAGSVVMAVSQLIVAIVGVAASSHAANQCLVAFSCIFIAGFAATWGPLCWAICGESFALNVRSKSISLCTASNWLWNFGIGYATPYMVDSGKGNADLGSKVFFIWGGCNVIGGLFAYFMVYETKSLTLEQVDELYLKVDHAWQSKGFVPSVHAFRDDGDIEHISSDGKAEMVEVDENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRA7</accession>
    <name>A0A1D8PRA7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prr2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">PRR2</name>
        <name evidence="3" type="ordered locus">CAALFM_C703340CA</name>
        <name evidence="2" type="ordered locus">orf19.8921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711681.2">
        <property type="nucleotide sequence ID" value="XM_706589.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRA7"/>
    <dbReference type="SMR" id="A0A1D8PRA7"/>
    <dbReference type="STRING" id="237561.A0A1D8PRA7"/>
    <dbReference type="GeneID" id="3646723"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703340CA"/>
    <dbReference type="CGD" id="CAL0000181633">
        <property type="gene designation" value="PRR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03340C_A"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRA7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001476">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000181633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="318" mass="36793" checksum="949E886AE945A4DD" modified="2017-01-18" version="1">MMGFKKIFKVENQNSEYKFSRNDIKSSQLGKGITGSVDLYQSKTLPHFQYAVKTYHTKDIHESKKDYKTRVLYEYLILSKLSHCNIIKIYDYDVSFSGSTIKLFLELGTANLNQLIIKQTNTFNINEMLCIWKQITNAVNYLHELDICHRDLKLENVVFDVNYKLIKVIDFATAQKLNNNELSRGLVGSESYTAPETYSSIQYDGKSSDVWSLGIILCYLINKKQPWKSAMWSNSDYQQFINQDNFSQEPYFVDFPVESLLLTSQILEQDPLRRIKINDFFSDKWFSLIQYCGCGVAGGGIYNKTCGIDHGKSFRVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRC2</accession>
    <name>A0A1D8PRC2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">CPY1</name>
        <name evidence="16" type="ordered locus">CAALFM_C703360WA</name>
        <name evidence="15" type="ordered locus">orf19.8919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in degradation of small peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711679.2">
        <property type="nucleotide sequence ID" value="XM_706587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRC2"/>
    <dbReference type="SMR" id="A0A1D8PRC2"/>
    <dbReference type="FunCoup" id="A0A1D8PRC2">
        <property type="interactions" value="919"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRC2"/>
    <dbReference type="GeneID" id="3646721"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703360WA"/>
    <dbReference type="CGD" id="CAL0000177922">
        <property type="gene designation" value="CPY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03360W_A"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRC2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009026872" description="Carboxypeptidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="14">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000177922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="542" mass="61044" checksum="7FA1BEFD789A41FF" modified="2017-01-18" version="1">MKLSKSTLIATLALTATSTNALVVQNPFSNIQQALKLDLSYDKLTSKLTDTFEQGKANIISTIAKVMNEPLDGLTPEIKNIWSEMLMKFPNSITELNFKAPPKKGKITTQQFDFHVTDAQVPNHKLRIKSTPKDLGIDTVKQYSGYLDVVDEDKHFFYYFFESRNDPKNDPVILWLNGGPGCSSLTGLFFELGPSSIDKNLKPVYNPHSWNANASVIFLDQPINVGYSYSSQSVSNTIAAGKDVYAFLQLFFKNFPEYANLDFHIAGESYAGHYIPAFASEILTHPERNFNLTSVLIGNGLTDPLVQYEYYEPMACGEGGEPSVLEPEECDGMLNSLPRCLSLIESCYESGSVWSCVPATIYCNNGQMGPYQKTGRNVYDIRTMCEGSSLCYSQLEYIDQYLNLPEVKKALGAEVDEYQSCNFDINRNFMFAGDWMKPYQKNVIDLLEKELPVLIYAGDKDFICNWLGNQAWTNRLEWSGSKGFSKAPVKTWKVGKNAAGEVKNYKHFTFLRVFGGGHMVPYDQPENALDMVNRWISGDYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRN4</accession>
    <name>A0A1D8PRN4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rep1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">REP1</name>
        <name evidence="6" type="ordered locus">CAALFM_CR00140WA</name>
        <name evidence="5" type="ordered locus">orf19.7521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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                <person name="Dungan J."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715765.2">
        <property type="nucleotide sequence ID" value="XM_710672.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSA6"/>
    <dbReference type="SMR" id="A0A1D8PSA6"/>
    <dbReference type="STRING" id="237561.A0A1D8PSA6"/>
    <dbReference type="GeneID" id="3642580"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02760CA"/>
    <dbReference type="CGD" id="CAL0000177441">
        <property type="gene designation" value="RPD3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02760C_A"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSA6"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="36"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000177441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW31018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="480" mass="54048" checksum="7A976DE89CACF98E" modified="2017-01-18" version="1">MYQELPFDELKVDPRKRRVAYFYDQDVGNYFYGTGHCMKPHRIRMAHSLIMNYELYKKMEIYRAQPATNLELTQFHTDEYIDFIDRVTPDNLHLFEREQVIFNVGDDCPVFDGLGEFCKISCGGSMEGAARLNRGQADIAINYAGGLHHAKKSEASGFCYTNDIVLGIIELLRYHPRVLYIDTDVHHGDGVEEAFYTNDRVMTCSFHKFGEFFPGTGNLTDIGIGKGKYHAINIPLRDGIDDASYKSIFEPIITKIMEWYQPSAIVLQCGGDSLSGDRLGPFNLSMRGHANCVNFVRSLGVPMMVLGGGGYTIRNVARTWAFETGVCNGEILPKELPYNGYYEYYAPTYELDVRSANMTNANSKEYLDKILTQVISNLDNTKHTPSVQMNEVPLDMEDLGDVDEDMPDAIDTKGGSQFAKDKLVQADGEFYDDDEKDKGEKNIQENGNVNTNANENGNGNGNVIITEEEQAELDKLNNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSH7</accession>
    <name>A0A1D8PSH7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">YVH1</name>
        <name evidence="9" type="ordered locus">CAALFM_CR03570CA</name>
        <name evidence="8" type="ordered locus">orf19.11879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715177.2">
        <property type="nucleotide sequence ID" value="XM_710084.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSH7"/>
    <dbReference type="SMR" id="A0A1D8PSH7"/>
    <dbReference type="FunCoup" id="A0A1D8PSH7">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSH7"/>
    <dbReference type="GeneID" id="3643218"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03570CA"/>
    <dbReference type="CGD" id="CAL0000184045">
        <property type="gene designation" value="YVH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03570C_A"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSH7"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040010">
        <property type="term" value="P:positive regulation of growth rate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <source>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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</entry>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <dbReference type="PubMed" id="15123810"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="237561.A0A1D8PT51"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11488"/>
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    </evidence>
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            <dbReference type="CGD" id="CAL0000188224"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="255" mass="28576" checksum="F9F58126F5F38DD7" modified="2017-01-18" version="1">MAYEHNNQSNGSEGYGSYSYNGKDEYYSNNYRGSGGGGYRGSRGRVSRGNNYYGNSYRGGSSRGGGGYYKSYNNNYYGGRGGGHRSYSNYHDQGNDTAGSSTTSSQNGEYESQDNTQETEHSYSSRPHISGFHRGSYRGGFRGSYRGRGGGSFNNGLAATASPTTTRHYKDIINENKLKNFNNPWINIMRIEDEPTQNKLEKSYNDMTELDSSILELQKSKLKLEMSMSLIEKQIDKEGLHVELTNEKLEEFAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTG5</accession>
    <name>A0A1D8PTG5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">SMX4</name>
        <name evidence="9" type="synonym">LSM3</name>
        <name evidence="12" type="ordered locus">CAALFM_CR07330WA</name>
        <name evidence="11" type="ordered locus">orf19.6135.1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331098.1">
        <property type="nucleotide sequence ID" value="XM_019475553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTG5"/>
    <dbReference type="SMR" id="A0A1D8PTG5"/>
    <dbReference type="FunCoup" id="A0A1D8PTG5">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTG5"/>
    <dbReference type="GeneID" id="30515427"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07330WA"/>
    <dbReference type="CGD" id="CAL0000188432">
        <property type="gene designation" value="SMX4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07330W_A"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTG5"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000188432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="96" mass="10905" checksum="2344FB402B0F8580" modified="2017-01-18" version="1">MSTIQAEQQQDQQPLDLIRFQLDEYVLVKLRGARELKGKLQGYDSHCNMVLSDAEETIYTSNEDDDSENTSEEPIVKKTAMVFVRGDSVILISPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTI2</accession>
    <name>A0A1D8PTI2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rab family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">YPT31</name>
        <name evidence="10" type="ordered locus">CAALFM_CR07520CA</name>
        <name evidence="9" type="ordered locus">orf19.10153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2016-12" db="PDB data bank">
            <title>Crystal structure of YPT31, a Rab family GTPase from Candida albicans, in complex with GDP and Zn(II).</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH GDP AND ZN(2+)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710395.2">
        <property type="nucleotide sequence ID" value="XM_705303.2"/>
    </dbReference>
    <dbReference type="PDB" id="5UB8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="A=1-222"/>
    </dbReference>
    <dbReference type="PDBsum" id="5UB8"/>
    <dbReference type="SMR" id="A0A1D8PTI2"/>
    <dbReference type="FunCoup" id="A0A1D8PTI2">
        <property type="interactions" value="1021"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTI2"/>
    <dbReference type="GeneID" id="3647999"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07520CA"/>
    <dbReference type="CGD" id="CAL0000190363">
        <property type="gene designation" value="YPT31"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07520C_A"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTI2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031521">
        <property type="term" value="C:spitzenkorper"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
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        </source>
    </evidence>
    <sequence length="872" mass="100589" checksum="5FED7F65A92B67BB" modified="2017-01-18" version="1">MARNNKQQKSKSKNNKKKQQNHRKNDDEGNELSIYDNKIREFEDGILDARKYLQSDDIKVDLDEEIDSDDALGSDDDYDVLNSKFSQTIRDKARKKRSGKKVNESESEDEGYSSIDEGQLVTLSEAWDMDDRDLDETLGNTSQNDIVLNDTWETESSEDEEEGEDDDQDEEDEDEDDDSFEESTDEEEIFGNHDDDEDIDLLKTVDRLQSKIASRQPKERKKLIVETRQENEYNLPTGGNQLSLQDMMANINEDENNKAILLDKESKAIAIPLPKRIQQRNDRAAAYELSKKEISKWKDSVQALRQAEVLKFPMINQEQDTIRDSALTFRSDNVPTTELEKRINNVLTESSLVDDKKEATFEEIAVAKLSPEEMKKRTNELRLMRELMFRDEKRAKRIKKIKSKQYHKIQKRERLKNQEMVEGEDFDMEDEDHDTKRATERMSLKHKTQSQWAKSMIKSGLSKDASNRAELEEMLRQGEKLRTKQMGFEDGDQSDENADDIINEYDQDDIDDENNLRSKLGKGVMNMDFMKKAEARKREENLKELEMLRKLENGEGDLEIFEEDNSAVNVTKNQGRRIYTPAAASQINDNTNEQALEDIENDNAKSLDKKLAKKYKVIDNQETKTSAKSESNPEVLPVDESNPWLSSNTSANNDTTKKNSAKITTVDKESSKLAKAAAKLAKSKLKKHKSSDDNTLIDVNETLAVNDIYQDGSEDEDESVPTMFKQKDLIKQAFAGDDVVSEFENEKKRVIEEEDDKEEDLTLPGWGDWAGGDSKPKKRKVVRKIDGVMAKDRRKDKNMKNVIINEKVNKKNLKYQSSHVPYPFETREQYERSLRMPVGQEWTSKETHQKLTMPRVIVKQGTVIDPLKAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU56</accession>
    <name>A0A1D8PU56_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Long-chain fatty acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">FAA4</name>
        <name evidence="9" type="ordered locus">CAALFM_CR10160WA</name>
        <name evidence="8" type="ordered locus">orf19.7592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719354.1">
        <property type="nucleotide sequence ID" value="XM_714261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU56"/>
    <dbReference type="SMR" id="A0A1D8PU56"/>
    <dbReference type="FunCoup" id="A0A1D8PU56">
        <property type="interactions" value="889"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU56"/>
    <dbReference type="GeneID" id="3638973"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10160WA"/>
    <dbReference type="CGD" id="CAL0000190605">
        <property type="gene designation" value="FAA4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10160W_A"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU56"/>
    <dbReference type="OMA" id="KIFQWAA"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001676">
        <property type="term" value="P:long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000190605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="696" mass="77320" checksum="A7A1C8EF6BA32D6C" modified="2017-01-18" version="1">MAPLTIAVGEAKPGETAPRRKAAQKDGAVMRPTDSKATTMPEFIDECFKRNGNKDAMAWRDLKDVIVETKQITKVIDGKPTKVNKDWTYYEMGPYNYIKYPELLKLVQNYSKGLLELGLLPDQQSKLMVFAGTSHKWMQTFLAASFQGIPIVTAYDTLGESGLTHSLVQTESDAIFTDNQLLSQLIRPLQKASSVKYIIHGEEIDPKDGRQNGKLYQDAKSAKEKILEIRPDIKFISYDEVIQSGANAKDKQSLHYPKPEDPICIMYTSGSTGDPKGVVITNSNIIAAIGGISCNAGRDLIRPTDRLIAFLPLAHIFELAFECITFWWGVPLGYANVKTLTEASCRNCQPDLIEFKPTVMVGVAAVWESVRKGVLSKLKQASPIQQKIFWAAFKAKTTFKHFGIPGADMFDVVFKKVKSATGGQLRYVLNGGSPISVDAQVFISTLIAPMLLGYGLTETCANAAILEHTHFQIGTLGTLVGSITAKLVDVADAGYYAKNNQGEIWLKGGPVVSEYYKNEKETKEAFTDDGWFKTGDIGEWTSDGGLKIIDRKKNLVKTLNGEYIALEKLESVYRSNHLVQNLCVYADQSKVKPIAIVLPIENNLRQMLKEEKVIDNAETEEFAHLVHDKKVTKAVLKHLLTTGKHQGLKGIELLQNVVLSDDEWTPQNGFVTSAQKLQRKKILESCKKEVQEAYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU93</accession>
    <name>A0A1D8PU93_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">RFC4</name>
        <name evidence="10" type="ordered locus">CAALFM_CR10700WA</name>
        <name evidence="9" type="ordered locus">orf19.7658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719417.1">
        <property type="nucleotide sequence ID" value="XM_714324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU93"/>
    <dbReference type="SMR" id="A0A1D8PU93"/>
    <dbReference type="FunCoup" id="A0A1D8PU93">
        <property type="interactions" value="806"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU93"/>
    <dbReference type="GeneID" id="3638994"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10700WA"/>
    <dbReference type="CGD" id="CAL0000187522">
        <property type="gene designation" value="RFC4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10700W_A"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU93"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000187522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="323" mass="36271" checksum="AD18E753C0D05E50" modified="2017-01-18" version="1">MSKPVTLELPWVEKYRPKKLEDIVGNEETVERLKLIVQDGNMPNMIISGLPGIGKTTSIHCLAYELLGDEHYHQATMELNASDDRGIDVVRNKIKQFAQTKISLPPGRQKIIILDEADSMTPGAQQALRRTIEIYSNTTRFAFACNQSSKIIEPLQSRCAILRYNRLSDEEVLARLLEIIKMEDVKYNTEGLQALIFTAEGDMRQAINNLQSTVAGFGFVNDVNVFKIVDQPHPLVIQSILLSCLKDKDIDKALGLLDGLWYKGYSAIDIVTSTFKVAKTIPNISEQKRLDVIKEIGFAHMRVLEGVATYLQLCGLYAKICDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU95</accession>
    <name>A0A1D8PU95_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">PRO1</name>
        <name evidence="12" type="ordered locus">CAALFM_CR10580WA</name>
        <name evidence="11" type="ordered locus">orf19.7638</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719398.1">
        <property type="nucleotide sequence ID" value="XM_714305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU95"/>
    <dbReference type="SMR" id="A0A1D8PU95"/>
    <dbReference type="FunCoup" id="A0A1D8PU95">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU95"/>
    <dbReference type="GeneID" id="3639000"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10580WA"/>
    <dbReference type="CGD" id="CAL0000178490">
        <property type="gene designation" value="PRO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10580W_A"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU95"/>
    <dbReference type="OMA" id="NLAFPPH"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="308"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000178490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="423" mass="46342" checksum="A07D616F334F357E" modified="2017-01-18" version="1">MTKQFTIVIKLGTSSLVDEVTREPRIANMSLIVETMVRLRRQGHKIVIVSSGAIACGMKQVGLEEKPANLSAVQALASIGQVRLIRTFDDLFRQLEQPIAQILLTRNDIMDFTQYKNAQNTLNELMDMGIIPIVNENDTLSVSEIKFGDNDSLSAITAGIIHADYLFLMTDVECLYTDNPRTNPDAQPILVVDKIDDLHVKTDTESGAGSKVGTGGMTTKLIAADLATNAGVTTIITLSSQPYYIIDIVAHIQAHADTLSVENQRLALQKDIQQGKIPLHTRFLSKPQDTLIKSDRRFWLLHGLKTKGALVIDQGCFQALTRRNRAGLLPVGILHVVGNFHQSECVSIKVVPDKNGAIDDAVEVGHCRVNYSAPEITLIKGHKSSEIEAILGYADSEYVAHRDNLAFPPVMPPSTDSLISDSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>P0C075</accession>
    <accession>A0A1D8PDM1</accession>
    <name>ATG8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related ubiquitin-like modifier ATG8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG8</name>
        <name type="ordered locus">CAALFM_C105700WA</name>
        <name type="ORF">CaO19.10016.1</name>
        <name type="ORF">CaO19.2480.1</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2019" name="Biochem. Biophys. Res. Commun." volume="516" first="1152" last="1158">
            <title>Function of Atg11 in non-selective autophagy and selective autophagy of Candida albicans.</title>
            <authorList>
                <person name="Cui L."/>
                <person name="Zhao H."/>
                <person name="Yin Y."/>
                <person name="Liang C."/>
                <person name="Mao X."/>
                <person name="Liu Y."/>
                <person name="Yu Q."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="31284951"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2019.06.148"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2016" name="Fungal Genet. Biol." volume="95" first="1" last="12">
            <title>The malfunction of peroxisome has an impact on the oxidative stress sensitivity in Candida albicans.</title>
            <authorList>
                <person name="Chen Y."/>
                <person name="Yu Q."/>
                <person name="Wang H."/>
                <person name="Dong Y."/>
                <person name="Jia C."/>
                <person name="Zhang B."/>
                <person name="Xiao C."/>
                <person name="Zhang B."/>
                <person name="Xing L."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="27473887"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2016.07.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2018" name="Int. J. Med. Microbiol." volume="308" first="378" last="386">
            <title>Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans.</title>
            <authorList>
                <person name="Li J."/>
                <person name="Yu Q."/>
                <person name="Zhang B."/>
                <person name="Xiao C."/>
                <person name="Ma T."/>
                <person name="Yi X."/>
                <person name="Liang C."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="29544880"/>
            <dbReference type="DOI" id="10.1016/j.ijmm.2018.03.004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2023" name="Res. Microbiol." volume="174" first="103996" last="103996">
            <title>Atg8 and Ire1 in combination regulate the autophagy-related endoplasmic reticulum stress response in Candida albicans.</title>
            <authorList>
                <person name="Du J."/>
                <person name="Zhao H."/>
                <person name="Zhu M."/>
                <person name="Dong Y."/>
                <person name="Peng L."/>
                <person name="Li J."/>
                <person name="Zhao Q."/>
                <person name="Yu Q."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="36328097"/>
            <dbReference type="DOI" id="10.1016/j.resmic.2022.103996"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3 4 6">Ubiquitin-like modifier involved in autophagosome formation (By similarity). The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Also participates in membrane fusion events that take place in the early secretory pathway (By similarity). Regulates autophagy-related endoplasmic reticulum stress response (PubMed:29544880, PubMed:36328097). Also involved in resistance to oxidative stress (PubMed:27473887). Is essential for virulence (PubMed:29544880).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Induced during biofilm formation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The C-terminal 19 residues are removed to expose Gly-116 at the C-terminus. The C-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Attenuates tolerance to oxidative stress when PEX1 is also deleted (PubMed:27473887). Leads to hypersensitivity to ER stress and causes the loss of virulence when YSY6 is also deleted (PubMed:29544880).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATG8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
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        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
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    <feature type="lipid moiety-binding region" description="Phosphatidylethanolamine amidated glycine" evidence="1">
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        <source>
            <dbReference type="PubMed" id="29544880"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="31284951"/>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="31284951"/>
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    <sequence length="135" mass="15643" checksum="A5D1B50B0669AF6A" modified="2005-07-19" version="1" precursor="true">MRSQFKDEHPFEKRQAEAARIAQRFKDRVPVICEKVENSDIPEIDKRKYLVPVDLTVGQFVYVIRKRIKLPSEKAIFIFVNDILPPTAALISTIYEEHKDEDGFLYVLYSGENTFGEKLAIDISSLDFSDIPDYV</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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        <property type="nucleotide sequence ID" value="XM_705451.1"/>
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    <dbReference type="AlphaFoldDB" id="Q59LD5"/>
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        <location>
            <begin position="145"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <begin position="219"/>
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            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="357" mass="41570" checksum="AA3DB26C7D0F1A2F" modified="2005-04-26" version="1">MIIFYKFIEFFLQLINDKQILYQEMFQEYNKKFVNPKINQLKKDAMIDATLGPHYSISLNDQKPYSFSKSKVFITHDIKGKPITEYGDIDSQILPQQLELEPLTSSCSTAINSRLTSRANSVAHYSNNNNNDNYINDDYDRTFNTSSNWNQNRRYQQSSRYHSGRNNDNLIMNTPLTYLPQPSRYSTQTPSLNSNLSFNRYDRTPSPTRGTTMSRRYSNPNINNNNNNNNNNNNSFHSPSRIRSRPTSPNKLLSPTRQPRLEFDGIGNTTITNDDQDRDRFSPFKSPSPIHRGTYHHSSPNTVNPQQLHQQQQQLSQQQQSSQHNNSFGYPNYPYRSPSPTRRRPSDSPERPKPGWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-06-26" modified="2025-02-05" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NP1</accession>
    <accession>A0A1D8PPG9</accession>
    <name>CTR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Copper transport protein CTR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CTR1</name>
        <name type="ordered locus">CAALFM_C600790CA</name>
        <name type="ORF">CaO19.11130</name>
        <name type="ORF">CaO19.3646</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="J. Biol. Chem." volume="276" first="48988" last="48996">
            <title>DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans.</title>
            <authorList>
                <person name="Lane S."/>
                <person name="Birse C."/>
                <person name="Zhou S."/>
                <person name="Matson R."/>
                <person name="Liu H."/>
            </authorList>
            <dbReference type="PubMed" id="11595734"/>
            <dbReference type="DOI" id="10.1074/jbc.M104484200"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="Mol. Biol. Cell" volume="13" first="3452" last="3465">
            <title>Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition.</title>
            <authorList>
                <person name="Nantel A."/>
                <person name="Dignard D."/>
                <person name="Bachewich C."/>
                <person name="Harcus D."/>
                <person name="Marcil A."/>
                <person name="Bouin A.P."/>
                <person name="Sensen C.W."/>
                <person name="Hogues H."/>
                <person name="van het Hoog M."/>
                <person name="Gordon P."/>
                <person name="Rigby T."/>
                <person name="Benoit F."/>
                <person name="Tessier D.C."/>
                <person name="Thomas D.Y."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="12388749"/>
            <dbReference type="DOI" id="10.1091/mbc.E02-05-0272"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Microbiology" volume="149" first="1461" last="1474">
            <title>The Candida albicans CTR1 gene encodes a functional copper transporter.</title>
            <authorList>
                <person name="Marvin M.E."/>
                <person name="Williams P.H."/>
                <person name="Cashmore A.M."/>
            </authorList>
            <dbReference type="PubMed" id="12777486"/>
            <dbReference type="DOI" id="10.1099/mic.0.26172-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="1076" last="1087">
            <title>Transcriptional response of Candida albicans upon internalization by macrophages.</title>
            <authorList>
                <person name="Lorenz M.C."/>
                <person name="Bender J.A."/>
                <person name="Fink G.R."/>
            </authorList>
            <dbReference type="PubMed" id="15470236"/>
            <dbReference type="DOI" id="10.1128/EC.3.5.1076-1087.2004"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="Microbiology" volume="150" first="2197" last="2208">
            <title>The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1.</title>
            <authorList>
                <person name="Marvin M.E."/>
                <person name="Mason R.P."/>
                <person name="Cashmore A.M."/>
            </authorList>
            <dbReference type="PubMed" id="15256562"/>
            <dbReference type="DOI" id="10.1099/mic.0.27004-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="54" first="1335" last="1351">
            <title>Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p.</title>
            <authorList>
                <person name="Bensen E.S."/>
                <person name="Martin S.J."/>
                <person name="Li M."/>
                <person name="Berman J."/>
                <person name="Davis D.A."/>
            </authorList>
            <dbReference type="PubMed" id="15554973"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04350.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="334" first="1149" last="1158">
            <title>Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro.</title>
            <authorList>
                <person name="Singh V."/>
                <person name="Sinha I."/>
                <person name="Sadhale P.P."/>
            </authorList>
            <dbReference type="PubMed" id="16039996"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.07.018"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2009" name="Proteomics" volume="9" first="4770" last="4786">
            <title>Analysis of Candida albicans plasma membrane proteome.</title>
            <authorList>
                <person name="Cabezon V."/>
                <person name="Llama-Palacios A."/>
                <person name="Nombela C."/>
                <person name="Monteoliva L."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="19824013"/>
            <dbReference type="DOI" id="10.1002/pmic.200800988"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2006" name="Eukaryot. Cell" volume="5" first="180" last="191">
            <title>Cellular and molecular biology of Candida albicans estrogen response.</title>
            <authorList>
                <person name="Cheng G."/>
                <person name="Yeater K.M."/>
                <person name="Hoyer L.L."/>
            </authorList>
            <dbReference type="PubMed" id="16400181"/>
            <dbReference type="DOI" id="10.1128/EC.5.1.180-191.2006"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2013" name="Eukaryot. Cell" volume="12" first="954" last="961">
            <title>Regulation of copper toxicity by Candida albicans GPA2.</title>
            <authorList>
                <person name="Schwartz J.A."/>
                <person name="Olarte K.T."/>
                <person name="Michalek J.L."/>
                <person name="Jandu G.S."/>
                <person name="Michel S.L."/>
                <person name="Bruno V.M."/>
            </authorList>
            <dbReference type="PubMed" id="23584994"/>
            <dbReference type="DOI" id="10.1128/EC.00344-12"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 14">Required for high affinity copper (probably reduced Cu I) transport into the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 6 7 8 9 10 11 13 14">Expressed in limited copper conditions. Expression is positively controlled by MAC1 and TYE7. Induced during biofilm formation and contact with macrophages as well as by alkaline pH via RIM101. Expression is down-regulated by 17-beta-estradiol.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Impairs growth on solid low-copper and low-iron medium and displays altered morphology in response to copper-depleted conditions.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711319.1">
        <property type="nucleotide sequence ID" value="XM_706227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NP1"/>
    <dbReference type="SMR" id="Q59NP1"/>
    <dbReference type="STRING" id="237561.Q59NP1"/>
    <dbReference type="EnsemblFungi" id="C6_00790C_A-T">
        <property type="protein sequence ID" value="C6_00790C_A-T-p1"/>
        <property type="gene ID" value="C6_00790C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647077"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600790CA"/>
    <dbReference type="CGD" id="CAL0000196962">
        <property type="gene designation" value="CTR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00790C_A"/>
    <dbReference type="HOGENOM" id="CLU_093528_0_0_1"/>
    <dbReference type="InParanoid" id="Q59NP1"/>
    <dbReference type="OMA" id="YLEEVVW"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="PHI-base" id="PHI:6485"/>
    <dbReference type="PRO" id="PR:Q59NP1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0187">Copper transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000422812" description="Copper transport protein CTR1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11595734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12388749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="12777486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15256562"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="15470236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="15554973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="16039996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="16400181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="19824013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="21414038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="23584994"/>
        </source>
    </evidence>
    <sequence length="251" mass="27859" checksum="07DEEC1675196F64" modified="2005-04-26" version="1">MEFLKRHEGHMHMSDSATSMVTSATSAVMDMASATMSMTMSSSTSSSSGMAMEGMDHGSSHMAMNMWLTASFKDYPVVFKDLRASTKAQAFGIFVLLFFVAFLARMLEFVRNYLEEIVWKNNNYAEVEQGISQHSANLQSPPVKSCCDDNAKEVVSDESIDKQNSPQHEETTKARGTGKSLSLASTISRDIIRLALCIIPDLFAYSLMLAAMTYTLTYFFAVVIGSGVGRFVAERLMEHYRIKRGPPRNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P41</accession>
    <name>Q59P41_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C206320WA</name>
        <name evidence="5" type="ordered locus">orf19.12950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <location>
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            <end position="609"/>
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    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P87</accession>
    <accession>A0A1D8PM10</accession>
    <name>MED31_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SOH1</name>
        <name type="synonym">MED31</name>
        <name type="ordered locus">CAALFM_C404210CA</name>
        <name type="ORF">CaO19.1429</name>
        <name type="ORF">CaO19.9005</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711556.1">
        <property type="nucleotide sequence ID" value="XM_706464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P87"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q59P87"/>
    <dbReference type="EnsemblFungi" id="C4_04210C_A-T">
        <property type="protein sequence ID" value="C4_04210C_A-T-p1"/>
        <property type="gene ID" value="C4_04210C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646859"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404210CA"/>
    <dbReference type="CGD" id="CAL0000190883">
        <property type="gene designation" value="SOH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04210C_A"/>
    <dbReference type="eggNOG" id="KOG4086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071681_3_1_1"/>
    <dbReference type="InParanoid" id="Q59P87"/>
    <dbReference type="OMA" id="YLEYWCE"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="PRO" id="PR:Q59P87"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900233">
        <property type="term" value="P:positive regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000305719" description="Mediator of RNA polymerase II transcription subunit 31">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="146" mass="17672" checksum="4E4F276F246F3C1B" modified="2005-04-26" version="1">MSAQTDQPITEQQKKEQEQYTNLINSLPTRWEIELEFVQSLSNIPYVNYLAQNNYFNDENFINYLNYLQYWTQPEYSKFLVYPNCLHILKLLQDENFRKNIINQDFMNSLMNDMVKRWQSNANDQDENKEKEENKEVPEVRINGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PS2</accession>
    <name>Q59PS2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_CR05700CA</name>
        <name evidence="11" type="ordered locus">orf19.13963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711708.1">
        <property type="nucleotide sequence ID" value="XM_706616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PS2"/>
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        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PS2"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR05700CA"/>
    <dbReference type="CGD" id="CAL0000186518">
        <property type="gene designation" value="orf19.13963"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05700C_A"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047877_2_1_1"/>
    <dbReference type="InParanoid" id="Q59PS2"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
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    </dbReference>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
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    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000186518"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="300" mass="34375" checksum="C18962FD49DC3AE9" modified="2005-04-26" version="1">MYNPYGNAADAYQQQQQQQYQQQQQQPHSTNLQHPQPIHHVSSHQPPPGAAGGQFNFLNDPAAALASQFARSGFEQSNQYLQENFGSLQGDIKYYFQVSNSYVFKKIILILMPYNHKDWNRVSTKETGTNQFLPPNLDINAPDLYLPLMSFVTYILLWAAFQGINGDFHPQLFGYLASQTIAFSVLDVVIFKTGLYLLNCPQSKIYDIISFSGYKYVSIIVLLILKYLVGNYLGLFYYIVVLLLIANLSIFLMRSLRFLILPQSTSMNNTITSKQRKIRIQFLFVYSVIIQGLIILYMSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QL0</accession>
    <accession>A0A1D8PD76</accession>
    <accession>Q59QI3</accession>
    <name>ERFB_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase ERF2</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DHHC cysteine-rich domain-containing protein ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ras protein acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ERF2</name>
        <name type="ordered locus">CAALFM_C103920CA</name>
        <name type="ORF">CaO19.11946</name>
        <name type="ORF">CaO19.4466</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with ERF4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Autopalmitoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711960.2">
        <property type="nucleotide sequence ID" value="XM_706867.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QL0"/>
    <dbReference type="SMR" id="Q59QL0"/>
    <dbReference type="FunCoup" id="Q59QL0">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59QL0"/>
    <dbReference type="EnsemblFungi" id="C1_03920C_A-T">
        <property type="protein sequence ID" value="C1_03920C_A-T-p1"/>
        <property type="gene ID" value="C1_03920C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646413"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103920CA"/>
    <dbReference type="CGD" id="CAL0000174768">
        <property type="gene designation" value="orf19.11947"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03920C_A"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047581_1_0_1"/>
    <dbReference type="InParanoid" id="Q59QL0"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="PRO" id="PR:Q59QL0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212939" description="Palmitoyltransferase ERF2">
        <location>
            <begin position="1"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="227"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="431"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="5">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="5">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q8VDZ4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9UIJ5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="514" mass="59318" checksum="67243BB8BCCCFA20" modified="2017-03-15" version="3">MVSPSSPESNDDDDLTNADSAITPATSTITTDSPTKSSFDDYQSLSSIRIPITRRITPSLSPQYEESNISTTTSATTTTTQQQHQQQQLQQQQQQLRQMSSLSASKIEQAKTDVLNNKKISFIHRFITNWLIMDPNLISHYNNTNTRRFKNYQIENQGQSNFIYFLGGRLHTIKTKYPINLITLSLIIIPGILYIIFELSWQWRNFSPIIVIIFLYIWIISIFHFFKLSTCDAGKLPKNIHLPKKLITITTTTTTTNDNEIDHRNNYKVMGSPPDEYFNTVTLPYWKTNNDNNDNTKISKLANAYHSHGVQVKYCGTCHIWRPSRTSHCNTCQQCILNHDHHCIFLNNCIGQRNYKFFLWFLLYIVIACLYLLIISILQLCHYKFASHKESEIITTFNQSIKTHPISLLLLIYSCLAICYPGLLLAFHIFLTSQNITTREYLNFVYKKPSKSTDGGDGTRGFVNVYNTHSIWENLYINWLGKSNGVSLTFPRDYYHQGDIRFANIEPLGTFTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QN4</accession>
    <name>Q59QN4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_CR05140WA</name>
        <name evidence="15" type="ordered locus">orf19.8254</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711986.1">
        <property type="nucleotide sequence ID" value="XM_706893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QN4"/>
    <dbReference type="FunCoup" id="Q59QN4">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59QN4"/>
    <dbReference type="GeneID" id="3646400"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05140WA"/>
    <dbReference type="CGD" id="CAL0000193968">
        <property type="gene designation" value="orf19.8254"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05140W_A"/>
    <dbReference type="eggNOG" id="ENOG502SF4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1209709_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QN4"/>
    <dbReference type="OMA" id="PKIAKHT"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000193968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW31242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="237" mass="27811" checksum="066745E9AE57D65C" modified="2005-04-26" version="1">MASLYPLKFNEKLAFFYNTVAATLWFCCLGRFLILLPLVGRKFLPGGMADFFHVVSLLPIIESLFVKSVLRKKFTITSLWGISNGLKMVWLCYGVIFPHPKIAKHTSYSLLITSWCLQYFIHYFYYAFKVKTKSSFHFLFWLEYNNFYLTYPLGLVSEMILLFLSLAFVEQDSIYDYVLRAAFLAYIPIAYFAWGHLKSRKKKRYTEIMNKRNVRQVATLESTTTSTKNTSIELRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q59R13</accession>
    <accession>Q3MP06</accession>
    <name>Q59R13_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C703500WA</name>
        <name evidence="3" type="ordered locus">orf19.13975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712159.1">
        <property type="nucleotide sequence ID" value="XM_707066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59R13"/>
    <dbReference type="SMR" id="Q59R13"/>
    <dbReference type="FunCoup" id="Q59R13">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59R13"/>
    <dbReference type="GeneID" id="3646246"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703500WA"/>
    <dbReference type="CGD" id="CAL0000197448">
        <property type="gene designation" value="orf19.13975"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03500W_A"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_0_1_1"/>
    <dbReference type="InParanoid" id="Q59R13"/>
    <dbReference type="OMA" id="LLPKMFI"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000197448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="388" mass="44326" checksum="A36BD404A976531A" modified="2005-04-26" version="1">MRETTPLKKSYKKYKSTTREDDSEVSGYYDHEQQYEEYEDSFSMSKTTKYTLFTIIGLITLLALYFFTVFLPDYFIPEAVALKPIENISDIPVTLVPSSNKENSEANDKKMVDRIILIGDIHGHYIEFRKLLTKINYNKHKDHLIVLGDFISKGPDSFKTLDYLINNNIDCVLGNHEYYILQNYATFHGLDQPNFSSSESQPIAVKDSFNDDPEFLLAKKLEPHHVKYINNCSIIKKLGYVPNPKGKKKNKVGDGADYSQGIAVHAGIRPDLPLDQQDPIDNLEMRSLIGPFYNETTADPTIPNSKSWSKIYNSKNGEYPADYIVYYGHDAGRGLKIKKFTKGLDSRCDRNGKLSAMVISKKQVTVDVNDYDKKKSFELIEEVVQVNC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S43</accession>
    <accession>A0A1D8PQT5</accession>
    <accession>Q3MPL1</accession>
    <name>MED11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED11</name>
        <name type="ordered locus">CAALFM_C701290WA</name>
        <name type="ORF">CaJ7.0143</name>
        <name type="ORF">CaO19.6909</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712481.1">
        <property type="nucleotide sequence ID" value="XM_707388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S43"/>
    <dbReference type="SMR" id="Q59S43"/>
    <dbReference type="BioGRID" id="1229003">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59S43">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59S43"/>
    <dbReference type="EnsemblFungi" id="C7_01290W_A-T">
        <property type="protein sequence ID" value="C7_01290W_A-T-p1"/>
        <property type="gene ID" value="C7_01290W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645910"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701290WA"/>
    <dbReference type="CGD" id="CAL0000188346">
        <property type="gene designation" value="MED11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01290W_A"/>
    <dbReference type="eggNOG" id="ENOG502S3YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121031_0_0_1"/>
    <dbReference type="InParanoid" id="Q59S43"/>
    <dbReference type="OMA" id="IMDDNIG"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304318" description="Mediator of RNA polymerase II transcription subunit 11">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q99278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="168" mass="19417" checksum="B74D0F3D474F63AC" modified="2005-04-26" version="1">MSSLDNDKTENFIQERLDSLHEIDCKVVTLLDQFSSIFQSFYTKSKEDFSQQTSDIYSTLSKVAIDLRKEIKIMDDNIGAYDKNDDNVMILPISNVDQKNTKLGRKRLDLELAELKRLISDEKQVETLENESNNEIQPKTESDTNQVETNENGNDINNKESEDIEMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TB0</accession>
    <name>Q59TB0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C204330CA</name>
        <name evidence="3" type="ordered locus">orf19.11996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712946.1">
        <property type="nucleotide sequence ID" value="XM_707853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TB0"/>
    <dbReference type="SMR" id="Q59TB0"/>
    <dbReference type="FunCoup" id="Q59TB0">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59TB0"/>
    <dbReference type="GeneID" id="3645453"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204330CA"/>
    <dbReference type="CGD" id="CAL0000192420">
        <property type="gene designation" value="orf19.11996"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04330C_A"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="Q59TB0"/>
    <dbReference type="OMA" id="FTWFRYA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000192420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38269" checksum="909419F7E8F4C565" modified="2005-04-26" version="1">MPSFELDSLPYLNPNVDRRIAFITGGSSGLGFYSVLQLYLHGYTVYIAGRSKSRCLKSIKELKNKAIDIRSEYTSSQLNERFLGDLRFLEVDLSNLNSVISAVENFKKLEDHLHILINNAGAMALPYTLTIDKFEIQLQTNFVSPLVLTTKLLPILQKTADKFPKLPTPRIIYLGSFGHQFALPYFNLSNNLNHYPNFIFTWIRYGMAKVAGIHFMKMLTLRNPKVLFLTVHPGLVMNTNLFSYWTRLPIVGIIFWFAFYLFGYFFGVTSKEGADVVIKCALDENLTVENDNGKYFGPDGKESQPSSIATNMDYAARTWIWTIKELSQRGIDIPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TD5</accession>
    <name>Q59TD5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">NDH51</name>
        <name evidence="18" type="ordered locus">CAALFM_C204550CA</name>
        <name evidence="17" type="ordered locus">orf19.11971</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712921.1">
        <property type="nucleotide sequence ID" value="XM_707828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TD5"/>
    <dbReference type="SMR" id="Q59TD5"/>
    <dbReference type="STRING" id="237561.Q59TD5"/>
    <dbReference type="GeneID" id="3645444"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204550CA"/>
    <dbReference type="CGD" id="CAL0000186277">
        <property type="gene designation" value="NDH51"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04550C_A"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="InParanoid" id="Q59TD5"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000186277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW27481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="490" mass="53834" checksum="85FF25F6AB56D6BC" modified="2005-04-26" version="1">MLSNFKIKPRTLLRGLATAAADPAANPNRVHGGLKDQDRIFQNVYGTYGHDLKSAQKMGDWYKTKEIILKGDKWIIDEMKKSGLRGRGGAGFPSGLKWSFMNPPGWEKNVGPRYLVVNADEGEPGTCKDREIIRKDPHKLVEGCLLAGRAMNATAAYIYIRGEFYNETVVLQNAINEAYKAGLIGKNACGSGYDFDIYIHRGMGAYICGEETALIESIEGKAGKPRLKPPFPAGVGLFGRPTTVANVESVSVAPTILRRGGDWFASFGRERNAGTKLFCISGHVNEPCTVEEEMSIPLKELLEKHCGGIVGGWDNLLGVIPGGSSVPIMPKETCDNVLMDYDALRDVGSGLGTAAVIVMNKQTDIIRAIQRFSHFYKHESCGQCTPCREGTTWLQRMMDRFYTGQATEKEIDQIFELTKEIEGHTICALGDAAAWPVQGLIKSFRPVMVDRIKEFQQKHAGEHLEYGGWVDGGKVKNGVVIDNPLPSGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UG6</accession>
    <name>Q59UG6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR03250CA</name>
        <name evidence="2" type="ordered locus">orf19.9934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713231.1">
        <property type="nucleotide sequence ID" value="XM_708138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UG6"/>
    <dbReference type="GeneID" id="3645102"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03250CA"/>
    <dbReference type="CGD" id="CAL0000185164">
        <property type="gene designation" value="orf19.9934"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03250C_A"/>
    <dbReference type="HOGENOM" id="CLU_969760_0_0_1"/>
    <dbReference type="InParanoid" id="Q59UG6"/>
    <dbReference type="OMA" id="PLEFPKL"/>
    <dbReference type="OrthoDB" id="4026747at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="287" mass="31684" checksum="A79BA0A843C0DB04" modified="2005-04-26" version="1">MESRKPSLFNQLEPHNEDSDSTDISDISEDEDWEDDPPLSPKSQPLEFPKLDHDVPLPRPPSLLSCLLYNNGNNNNNSNNHTNTLHPSNNIPNGSDNNHVYKPRLLRSFTTPTALPALHTPLVKQESVVGISDINVSISSLTTTSSHLSMKNLLSKSSVNLYSAGSTTTTTTTAAMRPNKRLSQPDQLKPSPSSLTSSILFMSQPPDSATTPPPPILPRITTTDSELTDKLINNDELSKSLKESLLIDNRLAKIPLPEKVIDAGIFLKRESRLADEDDFDDYHSKGW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VX9</accession>
    <accession>A0A1D8PCP3</accession>
    <name>NNRE_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber>5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C102220CA</name>
        <name type="ORF">CaO19.11163</name>
        <name type="ORF">CaO19.3679</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW25907" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25907.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713773.1">
        <property type="nucleotide sequence ID" value="XM_708680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VX9"/>
    <dbReference type="SMR" id="Q59VX9"/>
    <dbReference type="FunCoup" id="Q59VX9">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VX9"/>
    <dbReference type="GeneID" id="3644595"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102220CA"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_3_0_1"/>
    <dbReference type="InParanoid" id="Q59VX9"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="PRO" id="PR:Q59VX9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000416331" description="NAD(P)H-hydrate epimerase">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="258" mass="28680" checksum="C78333556217515B" modified="2012-03-21" version="2">MSATAPFKTLSAKAAFQLDQELMSTGEFSIDQLMELAGLAVAKTIYKEYPPNEATTTTKNKFNPNKVLVLVGPGNNGGDGLVAARHLKLWNYDPIIYYPKRPASNQLYSRLIKQLQDLNVPELTTLTEVKHLLDSRDSKIKIIIDSIFGFSFKPPIREPFKDLINYLGQNHDHLPPIVSVDIPSGWDVDEGPGTEIDIQASCLISLTAPKPCAKLFVNSGPDKIHYLGGRFINPRIAKEYGIEDIVNKYQGDELIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q59X47</accession>
    <name>Q59X47_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kis1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">KIS1</name>
        <name evidence="7" type="ordered locus">CAALFM_C209230CA</name>
        <name evidence="6" type="ordered locus">orf19.11565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714255.1">
        <property type="nucleotide sequence ID" value="XM_709162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59X47"/>
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    <dbReference type="STRING" id="237561.Q59X47"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C209230CA"/>
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    <dbReference type="eggNOG" id="KOG1616">
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    <dbReference type="HOGENOM" id="CLU_033562_1_0_1"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="term" value="P:invasive growth in response to glucose limitation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
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    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="286"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="243"/>
            <end position="260"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000178270"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27906.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="412" mass="46722" checksum="F822AC48F2FF364E" modified="2005-04-26" version="1">MLSPKSTNQEAPATAPLDDINTTKDVSMVDVSKAEGENQQPPRRKSTIILTDEIDLDRMNIDNKESDKSNEQGDKMHIDRSLSNLNQQQHSQSSQSEPSQPEQQQQQQQQQQQQQQQPVAPDANIAVPVDIKWVQGGQKVYVTGSFTGWRKMIGLVKQPDDNFMITLGLPVGTHRFRFVVDNELRFSDFLPTATDQMGNFVNYIEITPENVQQHLLQEKEESNNESQQQELEKQQAKTGDKTSSQQASRRSSVSRSRSNSMWGLTNDDDDMGDGYSRYHDDESNALDEKTYQYIKDIPPIFTDPKVMEQYYVAIDKQSRNNNGQQQAWLHPPQLPPHLESVILNNFNNTENNSGALPIPNHVVLNHLATTSIKHNTLAVASIVRYKRKYLTQVLYAPLQQASSSSTTQEQQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-06-26" modified="2025-04-09" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Z29</accession>
    <accession>A0A1D8PHY4</accession>
    <name>AFT2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Iron-regulated transcriptional activator AFT2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Activator of iron transcription protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AFT2</name>
        <name type="ordered locus">CAALFM_C207170CA</name>
        <name type="ORF">CaO19.2272</name>
        <name type="ORF">CaO19.9812</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Microbiology" volume="156" first="2912" last="2919">
            <title>Role of Candida albicans Aft2p transcription factor in ferric reductase activity, morphogenesis and virulence.</title>
            <authorList>
                <person name="Liang Y."/>
                <person name="Wei D."/>
                <person name="Wang H."/>
                <person name="Xu N."/>
                <person name="Zhang B."/>
                <person name="Xing L."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="20595261"/>
            <dbReference type="DOI" id="10.1099/mic.0.037978-0"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E62367" last="E62367">
            <title>Aft2, a novel transcription regulator, is required for iron metabolism, oxidative stress, surface adhesion and hyphal development in Candida albicans.</title>
            <authorList>
                <person name="Xu N."/>
                <person name="Cheng X."/>
                <person name="Yu Q."/>
                <person name="Qian K."/>
                <person name="Ding X."/>
                <person name="Liu R."/>
                <person name="Zhang B."/>
                <person name="Xing L."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="23626810"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0062367"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Leads to hypersensitivity to oxidative stress.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709769.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Z29"/>
    <dbReference type="SMR" id="Q59Z29"/>
    <dbReference type="BioGRID" id="1226605">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q59Z29"/>
    <dbReference type="EnsemblFungi" id="C2_07170C_A-T">
        <property type="protein sequence ID" value="C2_07170C_A-T-p1"/>
        <property type="gene ID" value="C2_07170C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643511"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207170CA"/>
    <dbReference type="CGD" id="CAL0000183427">
        <property type="gene designation" value="AFT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07170C_A"/>
    <dbReference type="eggNOG" id="KOG4818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363283_0_0_1"/>
    <dbReference type="InParanoid" id="Q59Z29"/>
    <dbReference type="OrthoDB" id="4068596at2759"/>
    <dbReference type="PHI-base" id="PHI:2555"/>
    <dbReference type="PRO" id="PR:Q59Z29"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0H6</accession>
    <name>Q5A0H6_CANAL</name>
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        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 7</fullName>
        </recommendedName>
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        <name evidence="5" type="ordered locus">CAALFM_C202710CA</name>
        <name evidence="4" type="ordered locus">orf19.13257</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32253" checksum="96CA84A16E8DB2D6" modified="2005-04-26" version="1">MAPTEIKGFYVLPLKLTGTKSIHYIYFKKHESKGTANDNRSLFICNLPISTDLSTIKKFFQKVAIGSTIESFINSLLTDYPEDIWINLTKLTSDLDLVDAVDEQASKLPKNCGIVAFIDKASFTLAFNSLKKLSSSLTECEWPIQQFTSNYYLKQYQKQILDPNSLTEEVSQALIDFDKAEQQSIEELQSQRNLVDEDGFTLVVGSHRKTKAGILGKQKLASTVGVVKAQSKMKSKEKQDFYRFQLRQRKKEEMNELLNKFKLDQEKVRMMKEKKRFRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1F1</accession>
    <name>Q5A1F1_CANAL</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">orf19.10386</name>
    </gene>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715525.1">
        <property type="nucleotide sequence ID" value="XM_710432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1F1"/>
    <dbReference type="GeneID" id="3642811"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406640CA"/>
    <dbReference type="CGD" id="CAL0000197766">
        <property type="gene designation" value="orf19.10386"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06640C_A"/>
    <dbReference type="HOGENOM" id="CLU_083354_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A1F1"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971203" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000197766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="160" mass="18663" checksum="6DA1200C0C564B98" modified="2005-04-26" version="1">MKSISFILFTFLLFVAPILGKIQNVYLYVRSQNQTVNGNGLYSVKERPGINYFFLGPPNHAQKLIYDDQNYYIYQQVDPHTRYYFGIQRNILQLSKGNPQRVVMRRNGELNFRGDDKLYAVKNIGDPINYSKDHYAVKYYANKNNVPKHAPKVTVYAKKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-05-10" modified="2025-02-05" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1L6</accession>
    <name>GIT3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major glycerophosphoinositol permease GIT3</fullName>
            <shortName evidence="4">GroPCho permease GIT3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycerophosphodiester transporter GIT3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GIT3</name>
        <name type="ordered locus">CAALFM_C500880CA</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="33939" last="33952">
            <title>Glycerophosphocholine utilization by Candida albicans: role of the Git3 transporter in virulence.</title>
            <authorList>
                <person name="Bishop A.C."/>
                <person name="Ganguly S."/>
                <person name="Solis N.V."/>
                <person name="Cooley B.M."/>
                <person name="Jensen-Seaman M.I."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
                <person name="Patton-Vogt J."/>
            </authorList>
            <dbReference type="PubMed" id="24114876"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.505735"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT4 (PubMed:24114876). GIT3 acts as the major GroPCho permease (PubMed:24114876). Does not possess detectable glycerophosphoinositol (GroPIns) transport activity (PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:24114876). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:24114876).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)</text>
            <dbReference type="Rhea" id="RHEA:32911"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:32912"/>
        </physiologicalReaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">45 uM for glycerophosphocholine transport</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text>Expression is positively regulated by the transcription factor PHO4 (PubMed:24114876).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Triple deletion of GIT2, GIT3 and GIT4 impairs the uptake of glycerophosphocholine (GroPCho) and reduces virulence in a mouse model of blood stream infection (PubMed:24114876).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715741.1">
        <property type="nucleotide sequence ID" value="XM_710648.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1L6"/>
    <dbReference type="SMR" id="Q5A1L6"/>
    <dbReference type="STRING" id="237561.Q5A1L6"/>
    <dbReference type="GlyCosmos" id="Q5A1L6">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C5_00880C_A-T">
        <property type="protein sequence ID" value="C5_00880C_A-T-p1"/>
        <property type="gene ID" value="C5_00880C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642634"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500880CA"/>
    <dbReference type="CGD" id="CAL0000176352">
        <property type="gene designation" value="GIT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00880C_A"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="Q5A1L6"/>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="PHI-base" id="PHI:3822"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001406">
        <property type="term" value="F:glycerophosphodiester transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000439800" description="Major glycerophosphoinositol permease GIT3">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="24114876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="535" mass="59400" checksum="47CC2BEA8C2AA213" modified="2005-04-26" version="1">MSTRDLPHSFSELSYGWVKRIRAEFTVGKSKEQLLAEDYHSTTDEDSEVVTSVKANSLWPAFASGAGLFSDGYVNNSISTVLFCLKKIYPDEITKSNAINNIASIAFVGTVVGQLGFGYISDRIARKGGMMAANVMLIFFTLMCAVGSWGVTVQGFFACLTVWRFFLGVAIGAEYPTSSVIASEFANQLPPGKRNRYFSWFTNAMIDSGFVVSAFVPFVLIWIFTEKHLRALWRVAIGLGVIPPLSLFFMRLKMKNSSSFQKLHMKNVKYRDYPWWLIVKFYWFRLTIVSLIWFIYDFSAYSFGNFNTIIIGEIIPEAPIWKQWGWSIVFNLFYIPGAFLGAISADYIGPRLTLALGVGIQGVIGIAMSACLNSLKKHIAGFVVVFGIFTTFGEFGPGDNIGLLASKTSATAIRGQYYGIAAAIGKIGAFVGTWVFPAIQSKYANNANPDLQLQVPFYISSALCLFSACLAIFFCPQVGQDAIYKEDHDFVQYLSNNGFDINMLGEGGDVREVCRESDSLEKGKRDDFQVDNNSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2025-06-18" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4H9</accession>
    <accession>A0A1D8PKE8</accession>
    <name>SSN8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SSN8</name>
        <name type="ordered locus">CAALFM_C305740CA</name>
        <name type="ORF">CaO19.7355</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716596.1">
        <property type="nucleotide sequence ID" value="XM_711503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4H9"/>
    <dbReference type="SMR" id="Q5A4H9"/>
    <dbReference type="BioGRID" id="1224812">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A4H9">
        <property type="interactions" value="988"/>
    </dbReference>
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        <property type="gene ID" value="C3_05740C_A"/>
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    <dbReference type="GeneID" id="3641718"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305740CA"/>
    <dbReference type="CGD" id="CAL0000180084">
        <property type="gene designation" value="SSN8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05740C_A"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_034754_2_1_1"/>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
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        <property type="term" value="P:cellular response to heat"/>
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        <property type="term" value="P:meiotic cell cycle"/>
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        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000077">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0195">Cyclin</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000314270" description="RNA polymerase II holoenzyme cyclin-like subunit">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin N-terminal">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="434" mass="50364" checksum="3F5B3640BE525EE9" modified="2005-04-26" version="1">MSADYWNSSQRNQWQLTRFSLLEARRRVLLLERKMIQNGLIKDYPNIIYDYNMRIYLHNLLIKLGRRLNIRQIALATAEIYLTRFLTRVSLKEINVYLLITTCIYVACKIEECPQHIRLILSEARNIWPEYIPHDVTKLAEFEFYLIEEMDSYLLLHHPYKSLMQINEFLSNNYNVFGFKLTVEELQNAWSLINDSYITDLHLLLPPHTIAVAAIYITVVLKKNLSRVRQGNNNDNNININTMHISTGSSTNPININNNNNTNTSNNNGTTSTTTTTTAQETQVLGQDDNTEMNIDDLMNLTKSSNNSQDKSDDKMDIDNPLQSQVNLSQIQNQTQHQHQESTHNNTSSTNTGRNGINGQISQSNQELNNFDLDILDEDTIKINKFMNFLEHSHINLDEVVEAVQDMMNMYVLWNRYNEQGVKKALQVMLLNRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4N5</accession>
    <accession>A0A1D8PPP7</accession>
    <accession>O94001</accession>
    <name>RAD18_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RAD18</name>
        <name type="ordered locus">CAALFM_C601770WA</name>
        <name type="ORF">Ca20C1.14c</name>
        <name type="ORF">CaO19.10910</name>
        <name type="ORF">CaO19.3407</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the E2 ubiquitin conjugating enzyme UBC2, monoubiquitinates PCNA to promote two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypasses replication-blocking lesions without removing them; monoubiquitination promotes the translesion synthesis (TLS) pathway and leads to the recruitment of translesion polymerases for lesion bypass, whereas further polyubiquitination of PCNA promotes template-switching (TS) to the newly synthesized sister chromatid for synthesis past the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="AL033391">
        <property type="protein sequence ID" value="CAA21935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716717.2">
        <property type="nucleotide sequence ID" value="XM_711624.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4N5"/>
    <dbReference type="SMR" id="Q5A4N5"/>
    <dbReference type="BioGRID" id="1224731">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A4N5">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4N5"/>
    <dbReference type="EnsemblFungi" id="C6_01770W_A-T">
        <property type="protein sequence ID" value="C6_01770W_A-T-p1"/>
        <property type="gene ID" value="C6_01770W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641637"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601770WA"/>
    <dbReference type="CGD" id="CAL0000182971">
        <property type="gene designation" value="RAD18"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01770W_A"/>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="InParanoid" id="Q5A4N5"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="PRO" id="PR:Q5A4N5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23148">
        <property type="entry name" value="RING-HC_ScRAD18-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
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    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000056153" description="Postreplication repair E3 ubiquitin-protein ligase RAD18">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
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            <dbReference type="UniProtKB" id="P10862"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="378" mass="42482" checksum="E9A4E8D1607A8909" modified="2017-03-15" version="2">MNLKDITDPSDFKTTKLPALAELDILKRCYICKDLLNAPVRTQCDHTYCSQCIREFLLRDNRCPLCKTEVFESGLKRDPLLEEIVISYASLRPHLLRLLEIEKVESKQEVDREKSANESASNGNRNVNNDVDETVRVKDQSNADELGEEKGQAQHGEQVNEQTTEVISLLSDDEENGSDSLVKCPICFERMELDVLQGKHIDDCLSGKSTKRTPTDILSPKAKRPKQITSFFKPTIDTKTPSPPTSKASTTPTATPTTTLLKANVSSPSPVAQSTVHKGKPLPKLDFSSLSTQKIKAKLSDLKLPTTGSRNEMEARYLHYYVIYNANLDSNHPVKESILRQQLKQWEMVQHQPSFGDAEWKGAETGNWKELIARARSN</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A880</accession>
    <name>Q5A880_CANAL</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
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        <text evidence="1">Belongs to the nudE family.</text>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Med. Mycol." volume="42" first="461" last="473">
            <title>Isolation, characterization, and regulation of the Candida albicans ERG27 gene encoding the sterol 3-keto reductase.</title>
            <authorList>
                <person name="Pierson C.A."/>
                <person name="Jia N."/>
                <person name="Mo C."/>
                <person name="Lees N.D."/>
                <person name="Sturm A.M."/>
                <person name="Eckstein J."/>
                <person name="Barbuct R."/>
                <person name="Bard M."/>
            </authorList>
            <dbReference type="PubMed" id="15552648"/>
            <dbReference type="DOI" id="10.1080/1369378032000141471"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8">3-keto-steroid reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:15552648). ERG27 is a catalytic component of the C-4 demethylation complex that catalyzes the reduction of the keto group on the C-3 (PubMed:15552648). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-dehydro-4alpha-methylzymosterol + NADPH + H(+) = 4alpha-methylzymosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:36379"/>
            <dbReference type="ChEBI" id="CHEBI:1949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136486"/>
            <dbReference type="EC" id="1.1.1.270"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36380"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25 and ERG28. Also interacts with ERG7, but only in lipid particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Expression is increased by itraconazole (which targets the lanosterol demethylase CYP51/ERG11) and by zaragozic acid A (which targets the squalene synthase ERG9).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Leads to complete loss of both 3-keto reductase and oxidosqualene cyclase (performed by ERG7) activities, compromising all sterol synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="6"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717931.1">
        <property type="nucleotide sequence ID" value="XM_712838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A888"/>
    <dbReference type="SMR" id="Q5A888"/>
    <dbReference type="FunCoup" id="Q5A888">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A888"/>
    <dbReference type="GlyCosmos" id="Q5A888">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CR_01140C_A-T">
        <property type="protein sequence ID" value="CR_01140C_A-T-p1"/>
        <property type="gene ID" value="CR_01140C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640432"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01140CA"/>
    <dbReference type="CGD" id="CAL0000174882">
        <property type="gene designation" value="ERG27"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01140C_A"/>
    <dbReference type="eggNOG" id="KOG1478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029944_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A888"/>
    <dbReference type="OMA" id="WHNIDGY"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="UniPathway" id="UPA00770">
        <property type="reaction ID" value="UER00758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000525">
        <property type="entry name" value="3-keto-steroid reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0551">Lipid droplet</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000454176" description="3-keto-steroid reductase ERG27">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q12452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15552648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="15552648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="346" mass="38981" checksum="040CB9783ACAECEE" modified="2005-04-26" version="1">MSLLKDSTVAVITGTSSNLGFNIAVRLLEGLPDNKEITLVVTSRTLPKVKEVISDIKKYIVAKIPTKVNKVEFDYLLVDFTDMVSILSAYYELNKRYKHIDYLFINAAQGVYGGIDWTGAVLEVLQSPIEAVTNPTYKLQKVGVESGDKLGLVFQANVFGPYYFIHRIKHLLENGGKIVWVSSLMSSPKYLSFNDLQLLRSPASYEGSKRLVDLMHFGTYNKLEREHGIKQYLVHPGIFTSFSFFQYLNVFTYYGMLFLFYLARFLGSPYHNISGYIAANAPVAAALGQTKQNCKTASACTRSGKEYLLEEEIDSTGSDDVVSYLDTLTKEWDEKLKDQIVNTRQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAT0</accession>
    <accession>A0A1D8PDX0</accession>
    <name>DXO_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease RAI1</fullName>
            <shortName evidence="6">CaRai1</shortName>
            <ecNumber evidence="5">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD-capped RNA hydrolase RAI1</fullName>
            <shortName evidence="7">DeNADding enzyme RAI1</shortName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RAI1</name>
        <name type="ordered locus">CAALFM_C106800WA</name>
        <name type="ORF">CaO19.13610</name>
        <name type="ORF">CaO19.6230</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="4">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="6596" last="6606">
            <title>Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.</title>
            <authorList>
                <person name="Wang V.Y."/>
                <person name="Jiao X."/>
                <person name="Kiledjian M."/>
                <person name="Tong L."/>
            </authorList>
            <dbReference type="PubMed" id="26101253"/>
            <dbReference type="DOI" id="10.1093/nar/gkv620"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) IN COMPLEX WITH MANGANESE</scope>
        <scope>COFACTOR</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 4 5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Divalent metal cation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RAT1; the interaction is direct, stabilizes RAT1 protein structure and stimulates its exoribonuclease activity (By similarity). The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="5 1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718819.2">
        <property type="nucleotide sequence ID" value="XM_713726.2"/>
    </dbReference>
    <dbReference type="PDB" id="5BTH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=1-391"/>
    </dbReference>
    <dbReference type="PDB" id="5BUD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.99 A"/>
        <property type="chains" value="A/B=1-391"/>
    </dbReference>
    <dbReference type="PDBsum" id="5BTH"/>
    <dbReference type="PDBsum" id="5BUD"/>
    <dbReference type="AlphaFoldDB" id="Q5AAT0"/>
    <dbReference type="SMR" id="Q5AAT0"/>
    <dbReference type="FunCoup" id="Q5AAT0">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AAT0"/>
    <dbReference type="EnsemblFungi" id="C1_06800W_A-T">
        <property type="protein sequence ID" value="C1_06800W_A-T-p1"/>
        <property type="gene ID" value="C1_06800W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639496"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106800WA"/>
    <dbReference type="CGD" id="CAL0000178137">
        <property type="gene designation" value="orf19.13610"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06800W_A"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024877_4_1_1"/>
    <dbReference type="InParanoid" id="Q5AAT0"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5AAT0"/>
    <dbReference type="PRO" id="PR:Q5AAT0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110103">
        <property type="term" value="C:RNA polymerase II termination complex"/>
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    <sequence length="391" mass="45689" checksum="385566A27A162EB6" modified="2017-04-12" version="4">MAKSLPLNSRSKTTALKQPRELFSYARDIDGKYVYDDPENSLSYYYLPDSTIDTGIDLQGGYSKFKKIPDEQNLADFNSLLKAIIKYETSEGKKISSDIITFREIMTKILSLPYNLTDPIDLYVVPFDGQLFIKSDDELDMKRRKEQEVRMKQTNTVERYDYMKRCEYVGYKFETIATIPKPWSQVSRSQIENRNKKVVNNYEQYLSVIRTGIGNVKLVLAGEIDCCWDYLPDEQNKKLNHYVELKTSRIIENNSQVVSFEQKLFKAWCQCFLMGVTKIIYGFRDNNLILKNVELFNTEEIPILIKNNPLTNAATEKKINCTNALKWYGAVVDWLNTTVDKKDETKSYRLKYDPVRKSFTLSETESETNEKLRNGELLTPEFTEWRQSLKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2025-06-18" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAV3</accession>
    <accession>A0A1D8PDY3</accession>
    <accession>Q5AB43</accession>
    <name>RRF2M_CANAL</name>
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        <recommendedName>
            <fullName evidence="1">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="1">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="1">EF-G2mt</shortName>
            <shortName evidence="1">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MEF2</name>
        <name type="ordered locus">CAALFM_C107000WA</name>
        <name type="ORF">CaO19.13589</name>
        <name type="ORF">CaO19.6208</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW26352" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
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        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000385611" description="Ribosome-releasing factor 2, mitochondrial">
        <location>
            <begin position="19"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="807" mass="90224" checksum="0DDA477EF4CDAF0F" modified="2017-04-12" version="2" precursor="true">MFCRKYVFQTWKQLSRSYSTVNSIGAAKTRNIGIIAHIDAGKTTTTERMIYYSGRTKRIGNVDEGDTVTDYLPSERERGITIQSAAITLPWNQHKINIIDTPGHADFTFEVIRSLRVLDGAVTILDAVAGVEAQTEKVWKQASALNLPKVVYVNKMDRPGAGFSRTVQEVIQKLETRVVLCNLPYFETNKESDLEFKGVIDVIHQKLLKWNETDANGNEISVVNIDETTPDLLQILEKSRESMVETLGEYDERIIDSFLEHDENYLKIPPMLLDQVIRKATIDNYLTPVFCGASFRNIGVQPLMDGITKYLPSPLETSLPQITKNGKDVTKKVDGEKGLVVANDNNLTLALAFKVMTHSTRGPMTFVRVYSGKLNAASNLINTRTGKKLLIRKLLVMHGDSPEEVKSISAGNIGVIPGYETDFQTGDTLVSSAVAKRNFTAKDSAYRLLPIDIPPPLFNAAIEPHTAGDEAYMKQCVETLIREDPSLKVHLDKEMGQVVLSGMGELHLDIVRERLVNDMKAKVNLKDVVVSYKESFVGKREKEAVITNEEIEVAVTLSHIEDARDYVGQEGALVIEEDNNVILLSETASSEHVRATIDERRWKCENNLEELKEAILNGCLTALQMGGPILGFPLHSTLVTVNRWNVPVEVAQEQALNLMNASRQAVQSLKDEKKDFSILEPIMSTKVYVDSNDLGEVSHDLTQRCKAMIVEIQDQSTQNLETAAWAKDEAAKVYVPPDYTIKKNVSKFDDIANKKIIVAETPLREMIGYLSKLRALTRGRATFDMTLIGMRRAVGNRVDSIVEEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABB3</accession>
    <name>Q5ABB3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4 7">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C100510WA</name>
        <name evidence="8" type="ordered locus">orf19.13478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4 7"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719019.1">
        <property type="nucleotide sequence ID" value="XM_713926.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABB3"/>
    <dbReference type="SMR" id="Q5ABB3"/>
    <dbReference type="FunCoup" id="Q5ABB3">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABB3"/>
    <dbReference type="GeneID" id="3639311"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100510WA"/>
    <dbReference type="CGD" id="CAL0000175867">
        <property type="gene designation" value="orf19.13478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00510W_A"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ABB3"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000175867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="309" mass="34129" checksum="D56BAAA0E8575E38" modified="2005-04-26" version="1">MYRRAFVGSSRLFSTSSYFRSSYTSAARKTIADIHELYKTGESISMVTSHDFITSQILEQAKVDINLIGDSLANTTLGYDDTNELTLDEFLYHVKSVQRGNSHSLLVADMPFGSFESSIEQATTTAVKLIQKGKIQAVKIEGGNEEIIPTIKKIVSVGIPVMGHVGLTPQKHNSLGGYKLQGRSVDDSVRIFQECLNLQNAGVFAIVLECIPNKLSQYITDKLSIPTIGIGAGPYTSGQVLVISDLLGMKDGHVAKFVQQYNNFFQQGVEGVKQYTKDVKSKKFPNPDTHGYKMKKDVLDEFKEIAKDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2025-04-09" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AC37</accession>
    <accession>A0A1D8PPV8</accession>
    <name>PRP45_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PRP45</name>
        <name type="ordered locus">CAALFM_C602440CA</name>
        <name type="ORF">CaO19.12959</name>
        <name type="ORF">CaO19.5513</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719078.1">
        <property type="nucleotide sequence ID" value="XM_713985.1"/>
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    <dbReference type="STRING" id="237561.Q5AC37"/>
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        <property type="gene ID" value="C6_02440C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639166"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602440CA"/>
    <dbReference type="CGD" id="CAL0000177849">
        <property type="gene designation" value="PRP45"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02440C_A"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085411_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AC37"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="PRO" id="PR:Q5AC37"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SKI-int_prot_SKIP"/>
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        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
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    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
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        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="286" mass="33200" checksum="EE23347794848E77" modified="2005-04-26" version="1">MASCNLLVIQTTSIIMFSSLLSRPVNSSYDPSYHFSPVTREIKNDPTSNGVVSTTKNATPLAPSKYDTTIPLKKRYPNLVHNFPKPELDENVILETKKIIDSILNPSDEPTNDINYIKYENPNPNPNPNPNPNQEQQQQSSSSSSKIIQIKQFQEDPMLPPKFKLRKNRHERIIEDVTFVKDLKTKKLTKEDREFWNIPAAVSNWKNSQGFTIGLDKRMIGREHVPIEMNIEKFNDLSTALSDADLQAREDLKQRNEIRQQKQLQEKRLRDEKIKEIANRSKRRRY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ACW6</accession>
    <accession>A0A1D8PG24</accession>
    <name>GET1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Golgi to ER traffic protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guided entry of tail-anchored proteins 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GET1</name>
        <name type="ordered locus">CAALFM_C200320WA</name>
        <name type="ORF">CaO19.2101</name>
        <name type="ORF">CaO19.9649</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719547.1">
        <property type="nucleotide sequence ID" value="XM_714454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ACW6"/>
    <dbReference type="SMR" id="Q5ACW6"/>
    <dbReference type="FunCoup" id="Q5ACW6">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ACW6"/>
    <dbReference type="EnsemblFungi" id="C2_00320W_A-T">
        <property type="protein sequence ID" value="C2_00320W_A-T-p1"/>
        <property type="gene ID" value="C2_00320W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638798"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200320WA"/>
    <dbReference type="CGD" id="CAL0000180884">
        <property type="gene designation" value="orf19.9649"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00320W_A"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_2_0_1"/>
    <dbReference type="InParanoid" id="Q5ACW6"/>
    <dbReference type="OMA" id="AEWIISF"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="PRO" id="PR:Q5ACW6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000388583" description="Golgi to ER traffic protein 1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <sequence length="199" mass="22954" checksum="7D80BC825D27B7D8" modified="2005-04-26" version="1">MLLPDLHPYTILLSIFLVLVAKQLVATIGKSTIQEFVWLVYLKVSSNQSIKTYNSKQHELHETNRQKRAISAQDEYAKWTKLNRQADKLSAELQKLNQEIQQQKSSIDKASNALILVLTTLPIWIARVFYRKTHLFYIRQGIFPKYVEWVLALPFLPNGAVGLTIWMFAVNSVVSNFSFLVSFPFAKRVSKPVRDTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADN6</accession>
    <name>Q5ADN6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C306950WA</name>
        <name evidence="10" type="ordered locus">orf19.14097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:polyphosphate biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="SPX_dom"/>
    </dbReference>
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        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="837"/>
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            <end position="442"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADU7</accession>
    <name>Q5ADU7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endodeoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C307450CA</name>
        <name evidence="2" type="ordered locus">orf19.14036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719841.1">
        <property type="nucleotide sequence ID" value="XM_714748.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q5ADU7">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADU7"/>
    <dbReference type="GeneID" id="3638481"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307450CA"/>
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        <property type="gene designation" value="orf19.14036"/>
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    <dbReference type="eggNOG" id="KOG3020">
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    <dbReference type="InParanoid" id="Q5ADU7"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
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        <property type="entry name" value="Metal_Hydrolase"/>
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        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
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        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="12"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
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            <label>1</label>
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    </feature>
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        <ligand>
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            <label>1</label>
        </ligand>
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        <ligand>
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            <label>2</label>
        </ligand>
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        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000180350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="323" mass="37521" checksum="6CB377085DEF8A5F" modified="2005-04-26" version="1">MNDTFLNLSDSHCHFNPECTASDTEKFAERLNEQSKQIPDNYFHLMTTQHLDLEFMDTLLTRLENPRVLVPYFGVHPWFSHLFYIEGTPTKEEHYKNVLKPEPSNELLATLPDPISLHKHKDRFLEIINKHNLEIYGIGEIGLDKLFRVPNNGYCGNLNFPSSTENKLSACRVDINHQLDVFKFQLTLAEQLKKQVSLHCVKAHGLLFDQVKKFSNITVILHSYTGSIEQAQVWIKSLPQNRLYFSFSNWINGEKIEALKALVTALRPTQILIESDIDVDRSFIEQRQTKHFDHLDGIYKKIHEHIFIDSLQIHNNMLNSIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGV9</accession>
    <accession>Q3MPJ0</accession>
    <name>Q5AGV9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C701500WA</name>
        <name evidence="1" type="ordered locus">orf19.13932</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
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                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721415.1">
        <property type="nucleotide sequence ID" value="XM_716322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGV9"/>
    <dbReference type="GeneID" id="3637050"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701500WA"/>
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        <property type="gene designation" value="orf19.13932"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C7_01500W_A"/>
    <dbReference type="HOGENOM" id="CLU_056390_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AGV9"/>
    <dbReference type="OMA" id="DHHIGTK"/>
    <dbReference type="OrthoDB" id="4075408at2759"/>
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        <property type="component" value="Chromosome 7"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30517.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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    <accession>A0A1D8PGV5</accession>
    <accession>O59892</accession>
    <name>CHK1_CANAL</name>
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        <recommendedName>
            <fullName>Histidine protein kinase 1</fullName>
            <ecNumber>2.7.13.3</ecNumber>
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        <name type="primary">CHK1</name>
        <name type="ordered locus">CAALFM_C203320WA</name>
        <name type="ORF">CaO19.8515</name>
        <name type="ORF">CaO19.896</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
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        <citation type="journal article" date="1998" name="Yeast" volume="14" first="665" last="674">
            <title>Identification of a putative histidine kinase two-component phosphorelay gene (CaHK1) in Candida albicans.</title>
            <authorList>
                <person name="Calera J.A."/>
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            </authorList>
            <dbReference type="PubMed" id="9639313"/>
            <dbReference type="DOI" id="10.1002/(SICI)1097-0061(199805)14:7&lt;665::AID-YEA246&gt;3.3.CO;2-R"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="2">
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
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                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Microbiology" volume="145" first="1431" last="1442">
            <title>Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans.</title>
            <authorList>
                <person name="Calera J.A."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="10411270"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1999" name="Infect. Immun." volume="67" first="4280" last="4284">
            <title>Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis.</title>
            <authorList>
                <person name="Calera J.A."/>
                <person name="Zhao X.J."/>
                <person name="De Bernardis F."/>
                <person name="Sheridan M."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="10417206"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="7243" last="7247">
            <title>Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans.</title>
            <authorList>
                <person name="Yamada-Okabe T."/>
                <person name="Mio T."/>
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                <person name="Kashima Y."/>
                <person name="Matsui M."/>
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                <person name="Yamada-Okabe H."/>
            </authorList>
            <dbReference type="PubMed" id="10572127"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="42" first="981" last="993">
            <title>Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.</title>
            <authorList>
                <person name="Murad A.M."/>
                <person name="d'Enfert C."/>
                <person name="Gaillardin C."/>
                <person name="Tournu H."/>
                <person name="Tekaia F."/>
                <person name="Talibi D."/>
                <person name="Marechal D."/>
                <person name="Marchais V."/>
                <person name="Cottin J."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="11737641"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02713.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2002" name="Infect. Immun." volume="70" first="985" last="987">
            <title>Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro.</title>
            <authorList>
                <person name="Torosantucci A."/>
                <person name="Chiani P."/>
                <person name="De Bernardis F."/>
                <person name="Cassone A."/>
                <person name="Calera J.A."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="11796636"/>
            <dbReference type="DOI" id="10.1128/IAI.70.2.985-987.2002"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2002" name="Infect. Immun." volume="70" first="1558" last="1565">
            <title>Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis.</title>
            <authorList>
                <person name="Li D."/>
                <person name="Bernhardt J."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="11854244"/>
            <dbReference type="DOI" id="10.1128/IAI.70.3.1558-1565.2002"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2003" name="FEMS Yeast Res." volume="3" first="289" last="299">
            <title>The role of the Candida albicans histidine kinase (CHK1) gene in the regulation of cell wall mannan and glucan biosynthesis.</title>
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                <person name="Kruppa M."/>
                <person name="Goins T."/>
                <person name="Cutler J.E."/>
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            <dbReference type="PubMed" id="12689636"/>
            <dbReference type="DOI" id="10.1016/S1567-1356(02)00164-2"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="1062" last="1065">
            <title>The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans.</title>
            <authorList>
                <person name="Kruppa M."/>
                <person name="Krom B.P."/>
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                <person name="Bambach A.V."/>
                <person name="Cihlar R.L."/>
                <person name="Calderone R.A."/>
            </authorList>
            <dbReference type="PubMed" id="15302838"/>
            <dbReference type="DOI" id="10.1128/EC.3.4.1062-1065.2004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="4" first="409" last="416">
            <title>The histidine kinases of Candida albicans: regulation of cell wall mannan biosynthesis.</title>
            <authorList>
                <person name="Kruppa M."/>
                <person name="Jabra-Rizk M.A."/>
                <person name="Meiller T.F."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="14734021"/>
            <dbReference type="DOI" id="10.1016/S1567-1356(03)00201-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2004" name="Microbiology" volume="150" first="3305" last="3313">
            <title>Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter gene.</title>
            <authorList>
                <person name="Li D."/>
                <person name="Gurkovska V."/>
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                <person name="Calderone R."/>
                <person name="Chauhan N."/>
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            <dbReference type="PubMed" id="15470110"/>
            <dbReference type="DOI" id="10.1099/mic.0.27237-0"/>
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        <scope>INDUCTION</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="731" last="741">
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                <person name="Li D."/>
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                <person name="Tan X."/>
                <person name="Kruppa M."/>
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                <person name="Roman E."/>
                <person name="Pla J."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="19563901"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2009.06.008"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="16">
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            <title>The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole.</title>
            <authorList>
                <person name="Chauhan N."/>
                <person name="Kruppa M."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="17664325"/>
            <dbReference type="DOI" id="10.1128/AAC.00929-07"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="17">
        <citation type="journal article" date="2010" name="Microbiology" volume="156" first="1476" last="1486">
            <title>Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Holcombe L.J."/>
                <person name="McAlester G."/>
                <person name="Munro C.A."/>
                <person name="Enjalbert B."/>
                <person name="Brown A.J."/>
                <person name="Gow N.A."/>
                <person name="Ding C."/>
                <person name="Butler G."/>
                <person name="O'Gara F."/>
                <person name="Morrissey J.P."/>
            </authorList>
            <dbReference type="PubMed" id="20150241"/>
            <dbReference type="DOI" id="10.1099/mic.0.037549-0"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="18">
        <citation type="journal article" date="2010" name="Microbiology" volume="156" first="3432" last="3444">
            <title>Deletion of the Candida albicans histidine kinase gene CHK1 improves recognition by phagocytes through an increased exposure of cell wall beta-1,3-glucans.</title>
            <authorList>
                <person name="Klippel N."/>
                <person name="Cui S."/>
                <person name="Groebe L."/>
                <person name="Bilitewski U."/>
            </authorList>
            <dbReference type="PubMed" id="20688824"/>
            <dbReference type="DOI" id="10.1099/mic.0.040006-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="19">
        <citation type="journal article" date="2013" name="Zhonghua Yi Xue Za Zhi" volume="93" first="1109" last="1113">
            <title>Effects of histidine kinase gene CHK1 on some biological characteristics of Candida albicans.</title>
            <authorList>
                <person name="Su H.C."/>
                <person name="Cheng B."/>
            </authorList>
            <dbReference type="PubMed" id="23902848"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="20">
        <citation type="journal article" date="2013" name="Eukaryot. Cell" volume="12" first="875" last="888">
            <title>Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/alpha biofilms.</title>
            <authorList>
                <person name="Srikantha T."/>
                <person name="Daniels K.J."/>
                <person name="Pujol C."/>
                <person name="Kim E."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="23563485"/>
            <dbReference type="DOI" id="10.1128/EC.00071-13"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8 12 13 14 17 19 21">Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan and glucan biosynthesis. Regulates quorum sensing as well as hyphal formation, biofilm formation, chlamidospore formation, and virulence. Plays a prominent role in phagocyte activation. Involved in the covering of the most potent pro-inflammatory cell wall molecules, the beta-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="induction">
        <text evidence="9 11 15 18 20">Expression is detected as early as 1 hour after infection of reconstituted human esophageal tissue and increases thereafter up to 48 hours postinfection. Expression is also increased when cells are exposed to several types of stress. Expression is decreased by Pseudomonas aeruginosa secretions. Moreover, expression is regulated by NGR1 and BCR1.</text>
    </comment>
    <comment type="domain">
        <text>The protein kinase domain is predicted to be catalytically inactive.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The phosphorelay mechanism involves the sequential transfer of a phosphate group from His-2007 (H1) in the histidine kinase domain (transmitter domain) to Asp-2394 (D1) of the response regulatory domain (receiver domain). This transfer probably occurs between two CHK1 molecules, rather than intramolecularly.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6 7 8 10 11 13 14 16 17 19">Impairs the hyphal formation and attenuates the virulence in a mouse systemic candidiasis model and towards reconstituted human esophageal tissue. Leads to extensive flocculation under conditions that stimulate germ-tube formation. Also leads to increased growth-inhibitory and killing effect by human neutrophils (polymorphonuclear leukocytes) and to hypersensitivity to fluconazole and voriconazole.</text>
    </comment>
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    <dbReference type="EMBL" id="AF013273">
        <property type="protein sequence ID" value="AAC39451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_715924.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5AHA0"/>
    <dbReference type="SMR" id="Q5AHA0"/>
    <dbReference type="STRING" id="237561.Q5AHA0"/>
    <dbReference type="EnsemblFungi" id="C2_03320W_A-T">
        <property type="protein sequence ID" value="C2_03320W_A-T-p1"/>
        <property type="gene ID" value="C2_03320W_A"/>
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    <dbReference type="GeneID" id="3637394"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203320WA"/>
    <dbReference type="CGD" id="CAL0000185875">
        <property type="gene designation" value="CHK1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C2_03320W_A"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000835_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AHA0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PHI-base" id="PHI:11569"/>
    <dbReference type="PHI-base" id="PHI:136"/>
    <dbReference type="PRO" id="PR:Q5AHA0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051042">
        <property type="term" value="P:negative regulation of calcium-independent cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050765">
        <property type="term" value="P:negative regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900231">
        <property type="term" value="P:regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000349">
        <property type="entry name" value="Histidine kinase osmosensor and regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000679">
        <property type="entry name" value="Peroxide stress-activated histidine kinase mak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25503">
        <property type="entry name" value="TPR_CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000425798" description="Histidine protein kinase 1">
        <location>
            <begin position="1"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="358"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="2004"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2340"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="2">
        <location>
            <position position="2007"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="2394"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC39451." evidence="22" ref="1">
        <original>V</original>
        <variation>I</variation>
        <location>
            <position position="2298"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="10411270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="10417206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="10572127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="11737641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="11796636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="11854244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="12689636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="14734021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="15302838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="15">
        <source>
            <dbReference type="PubMed" id="15470110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="16">
        <source>
            <dbReference type="PubMed" id="17664325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="17">
        <source>
            <dbReference type="PubMed" id="19563901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="18">
        <source>
            <dbReference type="PubMed" id="20150241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="19">
        <source>
            <dbReference type="PubMed" id="20688824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="20">
        <source>
            <dbReference type="PubMed" id="23563485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="21">
        <source>
            <dbReference type="PubMed" id="23902848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="22"/>
    <sequence length="2471" mass="281795" checksum="752618E1C1A10F80" modified="2017-05-10" version="2">MSMNFFNSSEPARDHKPDQEKETVMTTEHYEFERPDVKAIRNFKFFRSDETETKKGPNLHISDLSPLESQSVPPSALSLNHSIIPDQYERRQDTPDPIHTPEISLSDYLYDQTLSPQGFDNSRENFNIHKTIASLFEDNSSVVSQESTDDTKTTLSSETCDSFSLNNASYLTNINFVQNHLQYLSQNVLGNRTSNSLPPSSSSQIDFDASNLTPDSIPGYILNKKLGSVHQSTDSVYNAIKIPQNEEYNCCTKASASQNPTNLNSKVIVRLSPNIFQNLSLSRFLNEWYILSGKHSSKEHQIWSNESLTNEYVQDKTIPTFDKESARFRPTLPINIPGILYPQEIINFCVNSHDYPLEHPSQSTDQKRFAMVYQDNDYKTFKELSMFTLHELQTRQGSYSSNESRRKSSSGFNIGVNATTTEAGSLESFSNLMQNHHLGATSTNGDPFHSKLAKFEYGVSKSPMKLIEILTDIMRVVETISVIHELGFVHNGLTSSNLLKSEKNVRDIKITGWGFAFSFTENCSQGYRNKHLAQVQDLIPYMAPEVLAITNSVVDYRSDFYSLGVIMYELVLGILPFKNSNPQKLIRMHTFENPIAPSALAPGWISEKLSGVIMKLLEKHPHNRYTDCHSLLHDLIEVKNMYISKLLDSGETIPNSNLNLSDRQYYLTKENLLHPEKMGITPVLGLKESFIGRRDFLQNVTEVYNNSKNGIDLLFISGESGRGKTIILQDLRAAAVLKQDFYYSWKFSFFGADTHVYRFLVEGVQKIITQILNSSEEIQNTWRDVILTHIPIDLSILFYLIPELKVLLGKKYTSIYKHKIGMGMLKRSFKEDQTSRLEIKLRQILKEFFKLVAKQGLSIFLDDVQWCSEESWRLLCDVLDFDSSGEVRESYNIKIVVCYALNADHLENVNIEHKKISFCRYAKQSHLNLREFSIPHIPLEDAIEFLCEPYTRSHDHECNSKKSDVIANLNCTNEYPQNTCKVIPSIIQELYQSSEGNVLLLIFLTRMTKLSGKVPFQRFSVKNSYLYDHLSNSNYGTTRKEILTNYLNMGTNSDTRALLKVAALISNGSGFFFSDLIVATDLPMAEAFQLLQICIHSRIIVPTSTYYKIPMDLIASDQTPFDLTDDNIWKLATLCSYKFYHDSICTHIIKELNASGEFKELSRLCGLRFYNTITKERLLNIGGYLQMATHFRNSYEVAGPEENEKYVEVLVQAGRYAISTYNMKLSQWFFNVVGELVYNLDSKTQLKSVLTIAENHFNSREFEQCLSVVENAQRKFGFDRLIFSIQIVRCKIELGDYDEAHRIAIECLKELGVPLDDDDEYTSENSLETCLGKIPLSVADIRGILKIKRCKNSRTLLMYQLISELIVLFKLQGKDKVRRFLTAYAMSQIHTQGSSPYCAVILIDFAQSFVNETTTSGMLKAKELSIVMLSLINRAPEISLSYVQSIYEYYFSCHAVFFESIEKMSDLIHPGNASSHCTRSSYYSSFHLIVNVSKIFFSCMNGESFKMFSTFKCKSYLTGDPQMPEMDNFLYDSEMLLAGHSELNEFMRKYQSFNQTSVGKFCYYLIVLLVMSREHRFDEAADLVLKVLEDLSEKLPVSFLHHQYYLICGKVFAYHQTKTPESEEQVERILARQFERYELWASTNKPTLLPRYLLLSTYKQIRENHVDKLEILDSFEEALQTAHKFHNVYDMCWINLECARWLISINQKRHRISRMVKQGLKILRSLELNNHLRLAEFEFDEYIEDEDHRNKWAGLTNNPTLDTVTTWQQQNMPDKVSPCNDKQLVHGKQFGKKEFDSHLLRLHFDGQYTGLDLNSAIRECLAISEALDENSILTKLMASAIKYSGATYGVIVTKKNQETPFLRTIGSQHNIHTLNNMPISDDICPAQLIRHVLHTGETVNKAHDHIGFANKFENEYFQTTDKKYSVVCLPLKSSLGLFGALYLEGSDGDFGHEDLFNERKCDLLQLFCTQAAVALGKERLLLQMELAKMAAEDATDEKASFLANMSHEIRTPFNSLLSFAIFLLDTKLDSTQREYVEAIQSSAMITLNIIDGILAFSKIEHGSFTLENAPFSLNDCIETAIQVSGETILNDQIELVFCNNCPEIEFVVGDLTRFRQIVINLVGNAIKFTTKGHVLISCDSRKITDDRFEINVSVEDSGIGISKKSQNKVFGAFSQVDGSARREYGGSGLGLAISKKLTELMGGTIRFESEEGIGTTFYVSVIMDAKEYSSPPFSLNKKCLIYSQHCLTAKSISNMLNYFGSTVKVTNQKSEFSTSVQANDIIFVDRGMEPDVSCKTKVIPIDPKPFKRNKLISILKEQPSLPTKVFGNNKSNLSKQYPLRILLAEDNLLNYKVCLKHLDKLGYKADHAKDGVVVLDKCKELLEKDEKYDVILMDIQMPRKDGITATRDLKTLFHTQKKESWLPVIVALTANVAGDDKKRCLEEGMFDFITKPILPDELRRILTKVGETVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AHH7</accession>
    <name>Q5AHH7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">ACP12</name>
        <name evidence="17" type="ordered locus">CAALFM_C204030CA</name>
        <name evidence="16" type="ordered locus">orf19.8439</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720943.1">
        <property type="nucleotide sequence ID" value="XM_715850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AHH7"/>
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    <dbReference type="FunCoup" id="Q5AHH7">
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    <dbReference type="STRING" id="237561.Q5AHH7"/>
    <dbReference type="GeneID" id="3637361"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204030CA"/>
    <dbReference type="CGD" id="CAL0000177869">
        <property type="gene designation" value="ACP12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04030C_A"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="448946at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000177869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW27430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="110" mass="12322" checksum="68C7F5D031250BF0" modified="2005-04-26" version="1">MFKLAFRSIRAPVARASFVKPIRFYVAPPISKDEVTSRAIQALKTVAPLQESNITLESSFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGEAVDYIYKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI92</accession>
    <name>Q5AI92_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C102720WA</name>
        <name evidence="8" type="ordered locus">orf19.10478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721460.1">
        <property type="nucleotide sequence ID" value="XM_716367.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI92"/>
    <dbReference type="SMR" id="Q5AI92"/>
    <dbReference type="STRING" id="237561.Q5AI92"/>
    <dbReference type="GeneID" id="3636825"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102720WA"/>
    <dbReference type="CGD" id="CAL0000187437">
        <property type="gene designation" value="orf19.10478"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02720W_A"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773852_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AI92"/>
    <dbReference type="OMA" id="HVKGVHD"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071280">
        <property type="term" value="P:cellular response to copper ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF137">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000187437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="397" mass="45922" checksum="FF45534CAD5FEA01" modified="2005-04-26" version="1">MSNPNESEPHTQPEINNASHIVKPEGSQTVNTGFICRWSDCTENTYNNLTSLVNHLNSKHIAQLPPGSNTKYICYWENCARYGLDQPSRFALISHCRTHTGEKPYFCPVPECEKHFTRSDALTKHVKAVHDLHSVKDQLNLLKDKARKGQIELGVNVEDLSEEDYLRIIEQDYEIQKPWWFTNEFLDVIRAGETDKLEEHNKDDDLDKQLEALPFDLKQYQLANSRYKQFINSLTSARASNEIEDEDEVDGLIPRSDDNNSVINVVRKQLQHEKPNKKFPRVMSNPVLERLSNDTKKLAHDYIRHENDQNDDDIDKISDLETLKTLHDKLANQLNTAYKINKVLANQLTSNIKMKRKLWVYTQLLMDANIQVGLPPEATSAPQRVMQDEYDEELLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJ63</accession>
    <name>Q5AJ63_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C301220WA</name>
        <name evidence="7" type="ordered locus">orf19.9297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C3_01220W_A"/>
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        <property type="entry name" value="Amide_Lactam_Regulators"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="335" mass="38867" checksum="51CF15F6F21D051F" modified="2005-04-26" version="1">MEIFINKIYPFFPVIEISDNKDSLNKFPPLLLNAIFLVASRCLPQNDNKDNNNNNNQPIRERCQELFERCKLLELCENNKIALIQSFLLMSIHEEGINGSSLSKEYITRACNLCGDLGITTLSGSNGTAVQDTQHRVYKKLYYDKSILIRLFWISYACDILSASTHAREVYYNMNDVFIDDVPKEFPELIKFVELSTLLYRTLGSHYRPHKGRIIDEKLFTDIQNWNSLVDHPWLKLLYSYICMINLRCEVDPITLDPQLINSLQIQFDNVANIDPFWFKFHIVGVHSLLHVTSLLNLLGNNDENLDTNNKIKTRLEDLKEIWWLAASGLKLFGK</sequence>
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    <accession>Q5AK62</accession>
    <accession>A0A1D8PP12</accession>
    <accession>Q5AKM5</accession>
    <name>SSD1_CANAL</name>
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        <recommendedName>
            <fullName>Virulence protein SSD1</fullName>
        </recommendedName>
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    <gene>
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        <name type="ordered locus">CAALFM_C504730CA</name>
        <name type="ORF">CaO19.11441</name>
        <name type="ORF">CaO19.3959</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Microbiology" volume="144" first="2941" last="2950">
            <title>Candida albicans SSD1 can suppress multiple mutations in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Chen C.Y."/>
                <person name="Rosamond J."/>
            </authorList>
            <dbReference type="PubMed" id="9846729"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Eukaryot. Cell" volume="7" first="1318" last="1327">
            <title>SSD1 is integral to host defense peptide resistance in Candida albicans.</title>
            <authorList>
                <person name="Gank K.D."/>
                <person name="Yeaman M.R."/>
                <person name="Kojima S."/>
                <person name="Yount N.Y."/>
                <person name="Park H."/>
                <person name="Edwards J.E. Jr."/>
                <person name="Filler S.G."/>
                <person name="Fu Y."/>
            </authorList>
            <dbReference type="PubMed" id="18515753"/>
            <dbReference type="DOI" id="10.1128/EC.00402-07"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Eukaryot. Cell" volume="12" first="411" last="419">
            <title>Bcr1 functions downstream of Ssd1 to mediate antimicrobial peptide resistance in Candida albicans.</title>
            <authorList>
                <person name="Jung S.I."/>
                <person name="Finkel J.S."/>
                <person name="Solis N.V."/>
                <person name="Chaili S."/>
                <person name="Mitchell A.P."/>
                <person name="Yeaman M.R."/>
                <person name="Filler S.G."/>
            </authorList>
            <dbReference type="PubMed" id="23314964"/>
            <dbReference type="DOI" id="10.1128/EC.00285-12"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Plays a role in resistance to host antimicrobial peptides such as protamine, RP-1, or human beta-defensin-2; allowing colonization of human tissues. Required for resistance to membrane permeabilization and maintenance of mitochondrial membrane potential upon exposure to RP-1.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Constitutively expressed and not cell-cycle regulated like its S.cerevisiae ortholog.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Decreases virulence in murine infection models.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721868.2">
        <property type="nucleotide sequence ID" value="XM_716775.2"/>
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    <dbReference type="STRING" id="237561.Q5AK62"/>
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        <property type="gene ID" value="C5_04730C_A"/>
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    <dbReference type="GeneID" id="3636520"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504730CA"/>
    <dbReference type="CGD" id="CAL0000187484">
        <property type="gene designation" value="SSD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04730C_A"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002333_0_3_1"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:symbiont-mediated evasion of host immune response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
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    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000424599" description="Virulence protein SSD1">
        <location>
            <begin position="1"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="CSD2" evidence="1">
        <location>
            <begin position="562"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="688"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="DIS3L2 C-terminal" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18515753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23314964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="9846729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1274" mass="141280" checksum="74146377AB95E932" modified="2017-05-10" version="2">MSSSQDYNNNSNNTPARVSSRKGKNLHVAHRRSPSELTNLMVEQYNLQRQLEEVQAQQKLLEEKQKQQQQQFTYPSAQGSSELAPPPISSGYGGNRSSHSRSSSINTHRRTGSGSGGTAHGHSRRHSLGLNEAIKAAANQKQSNRNSLSPTIPNEAKTDSSDDIGSFKFPPSGGDQGDTSGQSSSSHNRSRSLAYGQQSFKFPPTPDQSNDTRGNSLLPPNPNFSVTQSPDRGHNRRSSHFRTGSRGSGSNTNTDGINSNWRAQQQSPQQQQRQGGLLEPPQVGFTPGHKPRNSSYGGGSSVSSLQQFLPNNGGSNNSGQQGGHQGGGNNGRKTLFAPYLPQSSLPELINEGRLVTGTLRVNKKNRSDAYVSTDGLLDADIFICGSKDRNRALEGDLVAVELLIVDEVWESKKEKEEKKRRKDNTLHSRPLTDDIHNDATSAPNTAEGSVTGTSKEDGAGSNEEETGGLARRGSLKQRPTMKKNDDVEVEGQSLLLVEEEEINDEIKPLYAGHVVAVVDRIPGQLFAGTLGLLRPAQAAQAARDKKNGKESTVQNPKAPKIVWFKPTDKKVPLIAIPTEQAPKDFVENHEKYADRLFVASIKRWPITSLHPFGTLVSNLGPIDSPETEIDSILRDNNFLCDEYPDDDNDDIVSVNAYDLPSIEPEFENTQREEYLNDYIIAFTQNGEFVDHALHVKRISNTKIELGFHVADIAYFIKPGSSLDRKSKKRSSSVFLPQKTVNLFPKQVNKIVSFKENEKNLAVSVVFEIDTSNFEVEDLYIHESVIVPKQLVTYDAFDTILSGQSVDSISSATSDYVKTFSLIAKEFRRHRLSNRSLGITPNLTLLDQLDDEKVRLDLNIFKDSLAFDVISEISHKVNSAIAAKVHAGLGDQAILRRHPLPTLQKMETFVRKATSLGFKIDTTTSSTLQNSILKIDDPVKRKCVETLLYKCMSRGRYYVAGKQDTDSYAHYYFNLPLYTHFTAPLRRYADLIVHRQLKAVLNKQVEDKDLDSLKAITDYCNFKKDCAANAQEQAIHLLLSQTINEMSETAGQLLCMGTVVQVYESSFDVFIPEFGVEKRVHGDQLPLVKAEFDKNERILELWWEKGVDSATYIPPDEKSSLSYRNSIKNKYRTSALQAAKIQSKTALEKSTTPADSVAEKLAKLNLEPPKLVVPSLKSNELHEVEKDETKSMPSSPTQSEIPKNVRTNSSSRISSSGNTFSLEPYLQNTITRIEGDSYIQVIKELTQVPVLLRAEIGMALPCLTVRVLNPFAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKW4</accession>
    <name>Q5AKW4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">AGM1</name>
        <name evidence="23" type="ordered locus">CAALFM_C113760WA</name>
        <name evidence="22" type="ordered locus">orf19.12480</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722217.1">
        <property type="nucleotide sequence ID" value="XM_717124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKW4"/>
    <dbReference type="SMR" id="Q5AKW4"/>
    <dbReference type="FunCoup" id="Q5AKW4">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AKW4"/>
    <dbReference type="GeneID" id="3636138"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113760WA"/>
    <dbReference type="CGD" id="CAL0000181233">
        <property type="gene designation" value="AGM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13760W_A"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AKW4"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006045">
        <property type="term" value="P:N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="191"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="311"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="467"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="512"/>
            <end position="516"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0000181233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AOW26978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="544" mass="60477" checksum="BD4F03EC2A586D58" modified="2005-04-26" version="1">MSIEQTLSQYLPSHPKPQGVTFTYGTAGFRMKADKLDYVTFTVGIIASLRSKYLQGKTVGVMITASHNPPEDNGVKVVDPLGSMLESSWEKYATDLANASPSPSNDSEGEKNSLVEVIKNLVSDLKIDLSIPANVVIARDSRESSPALSMATIDGFQSVPNTKYQDFGLFTTPELHYVTRTLNDPDFGKPTEDGYYSKLAKSFQEIYTICESNNEKIDITIDAANGVGAPKIQELLEKYLHKEISFTVVNGDYKQPNLLNFDCGADYVKTNQKLPKNVKPVNNKLYASFDGDADRLICYYQNNDNKFKLLDGDKLSTLFALFLQQLFKQIDPTKISLNIGVVQTAYANGSSTKYVEDVLKIPVRCTPTGVKHLHHEAENFDIGVYFEANGHGTVIFNPEAEKKIFNYKPNNDNEAKAIKVLQNFSQLINQTVGDAISDLLAVLIVVHYLKLSPSDWDNEYTDLPNKLVKVIVPDRSIFKTTNAERTLVEPKGMQDEIDKLVAQYPNGRSFVRASGTEDAVRVYAEADTQNNVEELSKAVSELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKY0</accession>
    <name>Q5AKY0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kis2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">KIS2</name>
        <name evidence="5" type="ordered locus">CAALFM_C113610CA</name>
        <name evidence="4" type="ordered locus">orf19.12464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722202.1">
        <property type="nucleotide sequence ID" value="XM_717109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKY0"/>
    <dbReference type="STRING" id="237561.Q5AKY0"/>
    <dbReference type="GeneID" id="3636211"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113610CA"/>
    <dbReference type="CGD" id="CAL0000197988">
        <property type="gene designation" value="KIS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13610C_A"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445500_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AKY0"/>
    <dbReference type="OMA" id="IMHSPAD"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="562"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000197988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="745" mass="81814" checksum="1476B543EA6B47E8" modified="2005-04-26" version="1">MGNNTSTGNFHSSGSNKRQGNSSDSIRKSSASVNYNNSVDSSSDNRVRKSTANKNANSLDEEFSDLILHQVVKNSRTLEAAPLQPSPKGEPTNPHHQQSNVYSTHYNQFSDDLIEDEFNELNEGIVETEMGSLQRNIIPDQGFGNDPTNTTSSSDSTGTYNYSSTLNDDMEIDAPFPHDDDDDNDSDGVNKVFPQSRSRTPTPDLTKVDFTKIISQAPPGYDGDTNMNGSGSVPPPTQMMSAASVARNAHSPLPNSDHHQKNLQQQRQPQQQQQLQSSFPDNSCGNTHAYPQQHGRPTKILKTNQQSQQFLIPIEIKWVNTTKEAIHKIAIIGSFSNWRDVIKMYPSTSHPNEFVTTINLPLGVHKLLYIINNEYRVSDQLPTATDQEGIFFNWFEVIDDTHLFNHSLNQPNHIGASTDYDANIIRYDNTTTTTSEMSTTTTATTTTTPKYVQPQTWAPRPAGKSDVDKINQKETDLLYKMSKEASGEFEHVEFIEDTDATGNGNGATAGTAGQSQDSSTPQGHNNHEAINSVDEIAFDNNPYQNYELSTSSSSFLQTTGQIIENPVEYSSEIPEMFINYDYFKMKPADYELPEPPQLPPHLNNVLLNKMTSSSSSGSGSGSGYSSTSHGSGSMTQHLSSIGNVSTISGSLPKSQSLSSTIGSGSSSSVSNTGSYLNNKRPPLRRADSSYYASNKDAYHLSIPNHVILNHLMTTSIKNDVLTVACITRYSGKFVTQIIHSPADTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2025-04-09" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALU2</accession>
    <accession>A0A1D8PGE5</accession>
    <name>SPC24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable kinetochore protein SPC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPC24</name>
        <name type="ordered locus">CAALFM_C201730WA</name>
        <name type="ORF">CaO19.1484</name>
        <name type="ORF">CaO19.9059</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <text evidence="1">Associated with kinetochores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722533.2">
        <property type="nucleotide sequence ID" value="XM_717440.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALU2"/>
    <dbReference type="SMR" id="Q5ALU2"/>
    <dbReference type="STRING" id="237561.Q5ALU2"/>
    <dbReference type="PeptideAtlas" id="Q5ALU2"/>
    <dbReference type="EnsemblFungi" id="C2_01730W_A-T">
        <property type="protein sequence ID" value="C2_01730W_A-T-p1"/>
        <property type="gene ID" value="C2_01730W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635732"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201730WA"/>
    <dbReference type="CGD" id="CAL0000192334">
        <property type="gene designation" value="orf19.9059"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01730W_A"/>
    <dbReference type="eggNOG" id="ENOG502S52R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091441_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ALU2"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="PRO" id="PR:Q5ALU2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000246660" description="Probable kinetochore protein SPC24">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="252" mass="29160" checksum="BF90D35780BC4151" modified="2017-05-10" version="2">MTTSVDKLNKLIEEVNNQDELQLIEEINLYIKTLYELRQVKIDQLSNIIHQLNQQIITSNKEINQLNKINDYNYELINVNNFNFVSQQSFQFTNFDRSSSSSSESTNNIFQMINKRLNELDNLKVVIVKELTDLETNLNNLKYKQNNLHESMEDINDKLDKLLNDMDKSGIMEQDPSILRINLFRNLGIKLENMPPNANSGGGGDSNSNSSNNNNTEEDCVIITDDNNNVNILNIEPKLSDYFISNYIWDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALU4</accession>
    <name>Q5ALU4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hsk3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">HSK3</name>
        <name evidence="3" type="ordered locus">CAALFM_C201710WA</name>
        <name evidence="2" type="ordered locus">orf19.9057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722531.1">
        <property type="nucleotide sequence ID" value="XM_717438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALU4"/>
    <dbReference type="SMR" id="Q5ALU4"/>
    <dbReference type="STRING" id="237561.Q5ALU4"/>
    <dbReference type="GeneID" id="3635730"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201710WA"/>
    <dbReference type="CGD" id="CAL0000198613">
        <property type="gene designation" value="HSK3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01710W_A"/>
    <dbReference type="eggNOG" id="ENOG502SGDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2222872_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ALU4"/>
    <dbReference type="OMA" id="GMFMAAS"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000198613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="106" mass="11559" checksum="D6A78B6D344B4753" modified="2005-04-26" version="1">MSSSNTPNKQAISSNERQSIIRTTLTPPSSTTSGNHPDPSLSSSSATQRKLSHLNSQMAQLNANLCDFNDLLVTTCSQYQSIEKLGKIHASIFMAGHTVFEDENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMM6</accession>
    <name>Q5AMM6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">TIM12</name>
        <name evidence="14" type="ordered locus">CAALFM_C401740WA</name>
        <name evidence="13" type="ordered locus">orf19.12090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722692.1">
        <property type="nucleotide sequence ID" value="XM_717599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMM6"/>
    <dbReference type="SMR" id="Q5AMM6"/>
    <dbReference type="FunCoup" id="Q5AMM6">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AMM6"/>
    <dbReference type="GeneID" id="3635587"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401740WA"/>
    <dbReference type="CGD" id="CAL0000201723">
        <property type="gene designation" value="TIM12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01740W_A"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162151_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AMM6"/>
    <dbReference type="OMA" id="NYHEPDL"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000011">
        <property type="entry name" value="Mitochondrial regulator of splicing 5"/>
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        <source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </feature>
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    </evidence>
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        <source>
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        <recommendedName>
            <fullName>Suppressor of ferric uptake 1</fullName>
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    <gene>
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        <name type="ORF">CaO19.12333</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="1451" last="1469">
            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
            <authorList>
                <person name="Lan C.Y."/>
                <person name="Rodarte G."/>
                <person name="Murillo L.A."/>
                <person name="Jones T."/>
                <person name="Davis R.W."/>
                <person name="Dungan J."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="15387822"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Microbiology" volume="154" first="1502" last="1512">
            <title>Copper-dependent transcriptional regulation by Candida albicans Mac1p.</title>
            <authorList>
                <person name="Woodacre A."/>
                <person name="Mason R.P."/>
                <person name="Jeeves R.E."/>
                <person name="Cashmore A.M."/>
            </authorList>
            <dbReference type="PubMed" id="18451059"/>
            <dbReference type="DOI" id="10.1099/mic.0.2007/013441-0"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Cell Host Microbe" volume="10" first="118" last="135">
            <title>An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.</title>
            <authorList>
                <person name="Chen C."/>
                <person name="Pande K."/>
                <person name="French S.D."/>
                <person name="Tuch B.B."/>
                <person name="Noble S.M."/>
            </authorList>
            <dbReference type="PubMed" id="21843869"/>
            <dbReference type="DOI" id="10.1016/j.chom.2011.07.005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="207" last="225">
            <title>Candida albicans Hap43 is a repressor induced under low-iron conditions and is essential for iron-responsive transcriptional regulation and virulence.</title>
            <authorList>
                <person name="Hsu P.C."/>
                <person name="Yang C.Y."/>
                <person name="Lan C.Y."/>
            </authorList>
            <dbReference type="PubMed" id="21131439"/>
            <dbReference type="DOI" id="10.1128/EC.00158-10"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002956" last="E1002956">
            <title>Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.</title>
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                <person name="Chen C."/>
                <person name="Noble S.M."/>
            </authorList>
            <dbReference type="PubMed" id="23133381"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002956"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH SEF1</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5 7 8">Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 6 7">Repressed by the HAP43 transcription regulator. Expression is also under the control of MAC1.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723553.2">
        <property type="nucleotide sequence ID" value="XM_718460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AP95"/>
    <dbReference type="SMR" id="Q5AP95"/>
    <dbReference type="BioGRID" id="1217961">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AP95"/>
    <dbReference type="EnsemblFungi" id="C1_10020W_A-T">
        <property type="protein sequence ID" value="C1_10020W_A-T-p1"/>
        <property type="gene ID" value="C1_10020W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634867"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110020WA"/>
    <dbReference type="CGD" id="CAL0000194032">
        <property type="gene designation" value="SFU1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10020W_A"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040438_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AP95"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="PHI-base" id="PHI:2618"/>
    <dbReference type="PRO" id="PR:Q5AP95"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cellular response to copper ion"/>
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        <property type="term" value="P:cellular response to iron ion"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="ZnF_GATA"/>
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        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
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    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000422809" description="Suppressor of ferric uptake 1">
        <location>
            <begin position="1"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 1" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 2" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
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    </feature>
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            <begin position="1"/>
            <end position="61"/>
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        <location>
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            <end position="172"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="435"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="164"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
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        <location>
            <begin position="234"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="263"/>
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            <begin position="327"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        <location>
            <begin position="423"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="23133381"/>
        </source>
    </evidence>
    <sequence length="517" mass="56353" checksum="61718B320CB0BE45" modified="2017-05-10" version="2">MPTSPTESIPNSSTKEQPILPKMLPTAKSPHTTPAQSPQNSDHHHHHQQTPPQPTDGQQCSNCGTTKTPLWRRAPDGTLICNACGLYYRSNNTHRPVNLKRPPNTIAVVKEEEGSCKGDGRCNGTGGSAACKGCPAYNNRIVAKKALEKSPKNDSSRAPIDKSLKRSTSTDATTEDESSLAIACFNCGTTITPLWRRDDAGNTICNACGLFYRLHGSHRPIKMKRPTIKRRKRNVSDKKSKDEVQMHSSDQSPIVASDPISPTPHNNENNNNVTNITTTTKTPTRSPHYYQPPPQYPYQHHPINSTTSSAINRLPPISYQSPYQTAPLSHSPMQSSSSYSPGASSVIPSSYYPPYSGSGRIPNGPGPVPGPPPPPPPTQSQPHHQQITTSPTSQSYGSLRAPIHITKRGYTPENIRLPSIQLTSSTSSNSETKLPPITNHSEKCCSNCAGPKSLAPMAIDFTASYRFNNIDSQTKLTKEDQNDSEGVSRDNDTRDENKPIKQEEHRSALSIGKLLNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-02" modified="2025-06-18" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q9HFQ7</accession>
    <accession>A0A1D8PCW4</accession>
    <accession>O94018</accession>
    <accession>Q5AI60</accession>
    <name>RLA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein P1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S acidic ribosomal protein P1-A</fullName>
            <shortName>CaRP1A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPP1A</name>
        <name type="ordered locus">CAALFM_C103010WA</name>
        <name type="ORF">Ca49C10.02c</name>
        <name type="ORF">CaO19.10509</name>
        <name type="ORF">CaO19.2992</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2000-11" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning, expression and purification of the acidic ribosomal protein from Candida albicans.</title>
            <authorList>
                <person name="Abramczyk D."/>
                <person name="Tchorzewski M."/>
                <person name="Grankowski N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10321 / CCM 8215</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Taylor K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Component of the large ribosomal subunit (LSU) (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (Probable). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF317659">
        <property type="protein sequence ID" value="AAG33240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL033497">
        <property type="protein sequence ID" value="CAA21967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T52147">
        <property type="entry name" value="T52147"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721490.1">
        <property type="nucleotide sequence ID" value="XM_716397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9HFQ7"/>
    <dbReference type="SMR" id="Q9HFQ7"/>
    <dbReference type="BioGRID" id="1219933">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q9HFQ7">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9HFQ7"/>
    <dbReference type="EnsemblFungi" id="C1_03010W_A-T">
        <property type="protein sequence ID" value="C1_03010W_A-T-p1"/>
        <property type="gene ID" value="C1_03010W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636839"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103010WA"/>
    <dbReference type="CGD" id="CAL0000178222">
        <property type="gene designation" value="RPP1A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03010W_A"/>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="InParanoid" id="Q9HFQ7"/>
    <dbReference type="OMA" id="YSAHDHE"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="PRO" id="PR:Q9HFQ7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="82"/>
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        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; CAA21967." evidence="4" ref="2">
        <original>G</original>
        <variation>A</variation>
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P05318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="106" mass="10996" checksum="BB03BB1B0CE9547E" modified="2001-03-01" version="1">MSTESALSYAALILADAEVEITSEKLLALVTKANVEVEGIWADLFAKALEGKDLKEFFFNFSAAPAAAAAGGAAGGGAAAEEAAEEEKEEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCG9</accession>
    <name>A0A1D8PCG9_CANAL</name>
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        <submittedName>
            <fullName evidence="12">Mrs7p</fullName>
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        <name evidence="11" type="ordered locus">orf19.10831</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
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        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
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        <location>
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            <end position="402"/>
        </location>
    </feature>
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        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="435"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="508" mass="58127" checksum="58CC13854FF533D2" modified="2017-01-18" version="1">MNFLIRNTIIGQTCNSKQIFYKHARTLAIKSSLTSSIRYPLQPSLHNNLNANTINFPLVKSFIRHNSSKPQKSLSSPEQIKEKALETLEKSPATELVHKTAEEPKKSIWEKVKHEAKHYWDGTKLLGYEVKVSTKLLLKLMAGYELSRRESNQLQRTIVDVVRLVPFAMFVIIPFAELLLPIALKIFPNLLPSTYESTVDRQKKLAKLKKTRKAASEFIKNTMAESGGLKLSKKITDQERENFVQFFHCISMGKNPDRQQLIQVARLFKNDQVLDNLSRPQLVAMCNYMNLRPFGTDSILRYQIRHRLLNIIKDDKVIDYEGVDSLSILELQLACSQRGIKTSDKSPARLRDDLETWLDLRLRQKIPSTLLILSSAYTYGDKGNSIESYYDALLAVLSSIPDEVYNVAKLELSDDSKLKLNILKEQEEMIEEENEREKDTVTKVKDKIKLDDYEETASEGIKIEADDPVEGKNGNETQKKEESSSTKESNQDKVSTSKEPTKKEEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCI8</accession>
    <name>A0A1D8PCI8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C101610CA</name>
        <name evidence="3" type="ordered locus">orf19.10859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475066.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="3640225"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101610CA"/>
    <dbReference type="CGD" id="CAL0000179833">
        <property type="gene designation" value="orf19.10859"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01610C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PCI8"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111034" description="Protein YOP1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000179833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="291" mass="32854" checksum="4A998F57E0DF2D12" modified="2017-01-18" version="1">MGFISTLSVAVATIYPVLASCRAFEDYTRVTNSLASQNLKIGGFTVPLNYLYNRNLGGTPNSDPNDKSSSSTSTNISINDERALQIHLISIQKWFIYWIVIAIISLLENILFLKYVIPGYSIFRLTFNIWLIIPMISIKQEVDANSTFDNTIEWKKFTSNGAGLLYFSYIKPFIEQHIDCIRKFSINPLNFISVEKLRYLFNKSNQVSPNDTNNGNTSTGSSNNNNDYSNVLDSFVMVMNMKNKFTGGANSTRDINELDNKNTSADNEFDVVNITPETDSQVNKRKXXLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCN0</accession>
    <name>A0A1D8PCN0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GAL10</fullName>
            <ecNumber evidence="6">5.1.3.2</ecNumber>
            <ecNumber evidence="5">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">GAL10</name>
        <name evidence="18" type="ordered locus">CAALFM_C102150WA</name>
        <name evidence="17" type="ordered locus">orf19.11156</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="6"/>
    <dbReference type="EC" id="5.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713766.2">
        <property type="nucleotide sequence ID" value="XM_708673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCN0"/>
    <dbReference type="SMR" id="A0A1D8PCN0"/>
    <dbReference type="FunCoup" id="A0A1D8PCN0">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCN0"/>
    <dbReference type="GeneID" id="3644583"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102150WA"/>
    <dbReference type="CGD" id="CAL0000174041">
        <property type="gene designation" value="GAL10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02150W_A"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCN0"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019388">
        <property type="term" value="P:galactose catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060257">
        <property type="term" value="P:negative regulation of flocculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052574">
        <property type="term" value="P:UDP-galactose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000025">
        <property type="entry name" value="GAL10 bifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="16">
        <location>
            <begin position="7"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000174041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW25900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="675" mass="75451" checksum="C5AF930A635BB6D2" modified="2017-01-18" version="1">MSNEYILVTGGAGYIGSHTVIELISNGYKVVIVDNLSNSSYDAVARIEFIVKQHVPFYDVDIRNYEQLNKVFQDYKISGVIHFAALKAVGESTKIPLAYYDNNVSGTVNLLEVCKANDVKTIVFSSSATVYGDVTRFGDNSMIPIPEHCPMDPTNPYGRTKFIIESILKDIYNSDDAWKVAILRYFNPIGAHPSGLLGEDPLGIPNNLLPYLAQVAIGRREKLSIFGNDYNSRDGTPIRDYIHVVDLAKGHIAALAYLKNLQSKGLYREWNLGTGKGSTVFEVYHAFSKVVGRELPHEVVGRRAGDVLDLTAKPDRANKELQWKTELAIDDACKDLWKWTTENPFGFNIENYSWKEFDGFNNRLHSFVAGDLKVNLANRGALIQAITLKDSNMVKAYNNAEDFKSETNPFFGTTVGRYANRISNGEFKLNGKVYKLTKNEGANNLHGGANGFDKQDFFGPVVKSRDGKFFVDFLLVDKDGNDGFPGELEAIVHYTIDDSSVEIEYECQLLSGEATIVNMTNHSYFNVSNSDTIEGTEVKLITDKMLEVDSQLLPTGKFIENEKAASPIVLNENDVFDNCFIVDEECGIDTRDKPLKQVFEATSFVTNNKLKISTTEPAFQFYTGDGVNTKGFGKRCGFCVEPSRFINAINHKEWSNQVILKKGDVYGSKIKYEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCN8</accession>
    <name>A0A1D8PCN8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 4 regulatory subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">PSY2</name>
        <name evidence="9" type="ordered locus">CAALFM_C102280CA</name>
        <name evidence="8" type="ordered locus">orf19.11169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713779.2">
        <property type="nucleotide sequence ID" value="XM_708686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCN8"/>
    <dbReference type="SMR" id="A0A1D8PCN8"/>
    <dbReference type="FunCoup" id="A0A1D8PCN8">
        <property type="interactions" value="935"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCN8"/>
    <dbReference type="GeneID" id="3644567"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102280CA"/>
    <dbReference type="CGD" id="CAL0000200329">
        <property type="gene designation" value="PSY2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02280C_A"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCN8"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="PHI-base" id="PHI:9225"/>
    <dbReference type="PHI-base" id="PHI:9544"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000455">
        <property type="entry name" value="Psy2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="6">
        <location>
            <begin position="169"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="830"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="922"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="956"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00058488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000200329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="980" mass="110909" checksum="B1C97AE21545ABD7" modified="2017-01-18" version="1">MSSLKDCKLSKSKREELKALNNAGKTPRRVKVYLLNGDDWIDNGTGFCVGEIDDDTKLPYFLVRNETDNNNIILKSFLEGSIQYQRQQETLIVWTDSNGTDLALSFQETEGCADLCDFIIRVQQGNISPGISLYYVIPNINEGDDITELITGPIRYPPEIPNVENLDVVLETINQGTNAQFTRTNISEFIIENDYFTKLINVFNEAENNENANVLYNVSDIVKSLFLYNESSIIEYILSSEEKILGLVGILEYDSEYPNYKASHRNFLASQSYIKVIPVENIEIFKRDFYLNYLKDVVLARFLDDSTFNLIASLIYSNHLEIFNYIKDSEILEHLFSIYDNCNDEKNECNSIDNDDDNDDDNIKMKQRDGVKMLHQYVLIAKSSRKHDFFASLVKHGLLKMINFALNDKQDQIRVLGTELIVIIIEQDVSLVNSIDHEETTTTIDNSDPPILEELVHNNKATPQEIVEEEEEDIPSITPKEGKLRLSDDMTLISILSKLLVEDKNIGLKMQAFEALKTLLDPNIAASSSGGSNGLSPTTMGGMGTPNGSGSGSNSNSLFNSSNANANANANTNTNTNSVNKSIGINTNNIEEFKFTSEEFQEINTSTYFRAFYEQVAPKLFEKLIILANHNLESKQLQINTKHEELLYQLLCELISFCTLEHKMISLSSLSSSSFSSSSLSSRSFFIENHIPLGIAKLLIIDDCKPILKLTSIRCLKNLILLNDEFYTRYFINHDLWFYFFKFFNNVIDENNLANSTCLDFIEIVIKGCDIGLNNNNNNNNNNNSKRSNYILLAKHIYKKYGEFIEKKLNYVDTGKRLIDLVTHSLNSNSNSNVNKLNGGQTFNENNNNNNKEEYDEDDNEYDNENEDSDENIATNTDDLGLSEDEMLPHNASTPLNDEEDEAEQEGTRLYTDVTEEIRISEKKRPREESDEIKPTPIIDNATTTTTTTTITTTTAASNSNDNFNGTKKIALTTTSDNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCR3</accession>
    <name>A0A1D8PCR3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">MNN11</name>
        <name evidence="6" type="ordered locus">CAALFM_C102400CA</name>
        <name evidence="5" type="ordered locus">orf19.10444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721427.2">
        <property type="nucleotide sequence ID" value="XM_716334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCR3"/>
    <dbReference type="FunCoup" id="A0A1D8PCR3">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCR3"/>
    <dbReference type="GeneID" id="3636792"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102400CA"/>
    <dbReference type="CGD" id="CAL0000193393">
        <property type="gene designation" value="MNN11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02400C_A"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCR3"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000382">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000193393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW25924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="444" mass="51496" checksum="F7CFD4BCD7B999D4" modified="2017-01-18" version="1">MFGVGKSGTFKPKYGKNNPSSTSFLPLPATFHQINRKKRLPLILIVLFIIWYIFFNSFLSPFSYLFSKSISKIHYPQAHPLTSTQLIETSSKYIYPPIEHAPLLKQLTTRKLFIEHTYKENGIDKTGIKSLNFLDDPHENLQKAKEKEENDNSPLNAAKNYFKNQDKIVFKPKSGSSSSSSSKYPELVIVTAVDFNKYSLDGLTKIVQNRVDYAHLQNYGVYVRWSEEFLPILNNFQYLEDKERAKWIRVYCMKAAMFAFPKTKWFWYLDENGLIMNMNINIHDYMLKPEILNSIMLRDLPLIPPDGIIKTYKNARADSIRFILTQSNQKIETNSFLMKNDYIGKSMIDIWGDNLFFQYPNFPYGPDSALTHILQWHPFILSKTTIVPIKTIAASHKFKDNGLPGNSIYEDGDFVAQWSDCNNPSECENILNIYYNKLKKTPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCZ6</accession>
    <name>A0A1D8PCZ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chromatin-remodeling ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C103360WA</name>
        <name evidence="15" type="ordered locus">orf19.10553</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
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        </source>
    </evidence>
    <sequence length="1410" mass="161731" checksum="71D4D5285019AF20" modified="2017-01-18" version="1">MVKQYIPEEAELNPELYGLRRSHRERRGPAIVESDSEEDVAPSRKKKKVQDDYEDGISMDEDENDEFGDDDDDDDDIYYDGSFGAGKKMKSKPKTSKKQKGKNTKARKTKQSPSPPQELRFSSRNNKQVNYAIDYDEDDADLLESEPEFDEEDEEGDYYYYQQAIEPENERGIDIVMDHKLNEENAEKTGDPKIDYLFKIKWTDASHLHNTWEKYQDLKSFKGFRKLDNYIKQFIIYDDEIRNDPLTTKEDLEAMDIERERKRDEQDEYTHVERIVDSKRVETDDGETKLQYFVKWKRLYYDECSWEDAEEIAKIAPEQVTKYQQRLNSKILPSLSANYPLSQRPRFEKLFKQPVFIKNGELRDFQLTGLNWMAFLWSRNENGILADEMGLGKTVQTVAFLSWLIYARRQNGPHLVVVPLSTVPAWQETFEKWAPDVNCVYYLGNGEARKTIREYELYNQNRKPKFNVLLTTYEYILKDKNELGAFKWQFLAVDEAHRLKNAESSLYEALKGFKVSNRLLITGTPLQNNVKELAALCNFLMPGKFTIDQEIDFETIDSEQEQYIKDLQKKISPFILRRLKKDVEKSLPSKSERILRVELSDIQTEYYKNIITKNYAALNAGNRGSQISLLNIMSELKKASNHPYLFDGAEDKVLDKAGSPSRENTLKGIVMSSGKMVLLEQLLSRLRKEGHRVLIFSQMVRMLDILGDYMFIKGYQFQRLDGTVPSSKRKIAIDHFNAPGSKDFAFLLSTRAGGLGINLMTADTVIIFDSDWNPQADLQAMARAHRIGQKNHVSVYRFVSKDTVEEQILERARKKMVLEYAIISLGITDPSAKNGSKTEPSTNELSQILKFGAGTMFKENNNQQKLENLNLDDVLSHAEDHVTTPELGESNLGSEEFLKQFEVTDYKADVEWDDIIPQEELTKLKDEEKRKADEQYLQDQIAMYSRRKAAVRKFENGSSVPSDVEDSGEDSRPLRRRNAGDHQLSEKEIRGIYRSILKWGDLSGKWEQLVEEGSITNKNPVLVKHAYNEIISTSKQLVKEEEARRAVVLAELERKAEEQKRRPPVPGEPNQTALWIAKKKEKKAVLFEYQGVKNINAEIVLNRPVDMKLLEKIVTKTDSTNFVLPRHPKSVQAWSCEWTAKDDAMLLVGVYKFGYGSWVQIRDDPLLGLQNKLFLENPAAGKDATANQDGKESVKKVPGSVHLGRRVDYLFTLLRDEESDSSVGGSTPVGSVRKRIRKSTPVPHNSGSSNGSHNTLSGNSNGGTANNTGKHRKPVKLESSEKLAKQKRMNQQRSSASASPALGHAKFKEEKRDLEYESMDEGSCKSIMQPVTSSLHKLHKGSKGLDKHEWAKILKSELLNIGDFIESEVSKVQNKDKLRKHLWSFTGLYWPSKVPSNKIGAMYNRLKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PD25</accession>
    <name>A0A1D8PD25_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">AGE1</name>
        <name evidence="9" type="ordered locus">CAALFM_C103480CA</name>
        <name evidence="8" type="ordered locus">orf19.10568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721548.2">
        <property type="nucleotide sequence ID" value="XM_716455.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PD25"/>
    <dbReference type="SMR" id="A0A1D8PD25"/>
    <dbReference type="STRING" id="237561.A0A1D8PD25"/>
    <dbReference type="GeneID" id="3636913"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103480CA"/>
    <dbReference type="CGD" id="CAL0000187329">
        <property type="gene designation" value="AGE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03480C_A"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PD25"/>
    <dbReference type="OMA" id="QFRQMIE"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="560"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="716"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000187329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="958" mass="111196" checksum="30BE64CADDFA2E9F" modified="2017-01-18" version="1">MELLSQISFPYYQEDDTCVTLNKLSFTDELDSKRSVIALNEKKQVDTFNTIYTNTQQIVLQLASYIENPDDDEKSQFPLLIKISPEFNKLKLHVSIKPVVGFESRSLIIVKSRGVTDVDVLKNQLYDDNTQDKPMTELSKLEYRKLPIEENNHSFQKIIINDFFDPKIVNNTKLNISLWEHDSTSNEFRHFLNFSVWIDKLAPVETPINRSSFSLATKGQPLEEKSPESKLFSLGDFRKEFKIDIEDGPEFRKTLTRLENNIPWAKKIYSNLVDEFRVLESNVRRVTTSKIKVMDTIDQIVDLESTSLLKEFGFKSDFHIVFKAMFEPFEKNLNFFFENVCDHKLLNKIYANIGFTQIDSSAVYLELQKKFEADSKEYYSWLNKYLSNEKERPESKLLAKRKVFELSKFDYLNSLTKVTNNQYVNEVLENFFKFLNLKYDPRYPRLLDYHSFKDKKSNQNLLGDNYQIYMNVLLRFNSERYQFRQMIEACQTNEELTNLIRCNRLNHKSVSTSSSSPSTSTASPHNLVTSSIDEFIITKENWDLIFNDSKPPDNEIGPDDSEKSGILFTLGGQKKQGWHKEWVVLKKGQLIEYADWRKGRTPINKPIEIALANVKAITHDKRQFCFEVLTSTGSKHVFQAFDNDDRNKWVKALHNAGQLINTKRLEQAHAKSLSQEGRKKTIGKLITEFKDKPIIPGQDRSISPISLTSKAPPIEKDYLQMVRSAPDSDNSICIDCGSAESVEWISINTLTCFCINCASCHRNIGSHITRIRSLKMDKFENETELLLKYINNRVVNSYLEENLPSKEKITCDVDNETRLNFIRNKYQLKKYKSIIPDIDNLLIKAIQKINVPDALKYILCGADINLNIQINIPNRNEYLVITLFEYSLRKYIEIKEEHDRELGYKPKKLFIISELLILNGCKVSQHIKDLQKEDLGLTDAAVEYWKIRSLKLSGGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PD78</accession>
    <name>A0A1D8PD78_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ifd6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">IFD6</name>
        <name evidence="4" type="ordered locus">CAALFM_C104140WA</name>
        <name evidence="3" type="ordered locus">orf19.8650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713652.2">
        <property type="nucleotide sequence ID" value="XM_708559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PD78"/>
    <dbReference type="SMR" id="A0A1D8PD78"/>
    <dbReference type="STRING" id="237561.A0A1D8PD78"/>
    <dbReference type="GeneID" id="3644703"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104140WA"/>
    <dbReference type="CGD" id="CAL0000201829">
        <property type="gene designation" value="IFD6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04140W_A"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PD78"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018456">
        <property type="term" value="F:aryl-alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
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    <sequence length="724" mass="80956" checksum="F3FA3358DCCC86F8" modified="2017-01-18" version="1">MSDLNNNEDRFSFEESPIRTHPSSPTPHPTEDINRILSSEFQKRNTITGNFDTDPNSPQADTQSNHTSPISQQLINHMDMDRESIYSFDSVSTSGRLLDRLGLEDDDDDDNEDNVDHYETDSDTYTLTDKRESMTSIQTTGRLLDRLELDTRHKSIQQPPPPKQTNKILPIQPVNNLADIRGLKNKQNTQNSLSRREQLQPQPQSQPQLRSVVAQRQPPGQQQQQQQHHLQRINETPNLMQSVQRPIQKSQSGPIQNPQQALAHLKHVPMNLVFRNTNNSTETIKSDMASLKKFETRKSVVPEIRSIDSNDEVPPPPPLPSITPTSAISKNSFTPSPARSTESLGRSSLDQSPILSPILQPSPAGNSLESNGGHQGFVELNDENSVIGLSSMKPIQKSNSMKPMNNRPSMVMRTPSAPSLRNTMSIETNDTFDNSQTDFKLRSRSDTTNTTFNNNSNDSIDSGSTIFSARSQNTILNKDNSSSTNGGGPNAESRTNYAMELRGLGNHREASYQLQIAANEPYNYPRAMFLYAMALKFGQGVKQNYRHSIKWLTKCILLSSSHITSANISVVLEKLNALTIEDLIKLIMKNLTNTVDKDPHKNGQDPLILYPIFKALTKNQIAKVINISKIKGDVVAASYHELGNYLINGWGVTNKDETNGINCLSKAGSMGYIDSMVQLGEIWCSKTKNRKKDLTKAAGWLRLSEIFGVKSIGNSWIYKEKYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDU7</accession>
    <name>A0A1D8PDU7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Hak1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">HAK1</name>
        <name evidence="14" type="ordered locus">CAALFM_C106610CA</name>
        <name evidence="13" type="ordered locus">orf19.13627</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718838.2">
        <property type="nucleotide sequence ID" value="XM_713745.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDU7"/>
    <dbReference type="STRING" id="237561.A0A1D8PDU7"/>
    <dbReference type="GeneID" id="3639546"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106610CA"/>
    <dbReference type="CGD" id="CAL0000188660">
        <property type="gene designation" value="HAK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06610C_A"/>
    <dbReference type="eggNOG" id="ENOG502QPSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDU7"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015387">
        <property type="term" value="F:potassium:proton symporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
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            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="81"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="638"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000188660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW26317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="808" mass="89991" checksum="FBB4CAA278D4F5F3" modified="2017-01-18" version="1">MVESSASIRKSQDSANDNNSEIDQTELRYFTEVDIDEQPSSNTFDEEEDDEEDISSSANSAIEEEKGVSNKQSWRKVLMLCFSSLGSIYGDLGTSPLYVLNSIKYSSYPPNKEDIYGAVSIIFYIFTIIVIFKYVLIVLFIGVNCNHGGQVAIFAKIARHLGIGPRGVSLPGAPEASDMQLLTRQDTTTSSIKSTQTRVEKIKENPILLSFLQYFILGACFLGSALVMSDGLLTPTTSVLSAIGGIQVAVPSFSNVLAVSEVILIVLFVAQQFGASKLSFTFAPIIFIWMIGLILCGTYNIAKYNPGIFAALSPYYAIKLLKSGSIDVFSGAMLSITGTEALFSDVSVVGRLPIQLTMGFFVYPALMLCYLGQGAYLSSHPEAYSNPFFLSIPGGQGIYWTMFVLATLATIIASQALILSVFSISSQLINLDCFPKLKIVHLSSHQSGEVYIPVMNWLLMIGVICTTAGFKNSNNVTAAYGLGISMDFLVTSSLIIICLFYVYNANIIWPLLFLLIFVPLEVCMVVANLRKVPHGAWFPLLMAGIFFSFLCLWRWARSKKVDQEYEQRIKIGDLFPFFAAKSITVDLNHNEVSPNYSLQEQQQQQVSPYSKEDVVTKFGTVPLSRHPGLGFMYVDSIMTNSPNTLPQLYGKLITSFASIPSEFVFVGIRVLSIPYVNSDERILLAPMKIPGHYKCILRFGFMENVQIDKELSSKIMARIPGLSVLTPEQLHNHPIIHFFENDLIRCHQYHSGKRNYFKKFGHLIRKTIINHIYSPLYSLTQDKGGFLWYDNEKEESEKKLFIGGISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEG0</accession>
    <name>A0A1D8PEG0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C109000WA</name>
        <name evidence="4" type="ordered locus">orf19.12220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723442.2">
        <property type="nucleotide sequence ID" value="XM_718349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEG0"/>
    <dbReference type="FunCoup" id="A0A1D8PEG0">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEG0"/>
    <dbReference type="GeneID" id="3634915"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109000WA"/>
    <dbReference type="CGD" id="CAL0000194856">
        <property type="gene designation" value="orf19.12220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09000W_A"/>
    <dbReference type="eggNOG" id="ENOG502QRB1">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEG0"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
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        <location>
            <begin position="389"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="459"/>
            <end position="482"/>
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        <location>
            <begin position="229"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000194856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="551" mass="62068" checksum="A2BD09C589B3DC7A" modified="2017-01-18" version="1">MFTKNFSTFKPYKHLSYLINCIHLINLLTINNHKKMTKRYINSSWCLIILSSFLLSLVSADEDGMSMDMGDPSSRPEFHPINPGSKTFHWLLTLFILLILPSISTSLAIANKLHWSLFLQYISTGYSIFESMFLDFPDNIDNHENKTSKGTSWFLSILLGLTIFLGTFINGSNLIINKFYPHLQTRQNSNSNSNSNSNSNSNSNSNSNYEYGISYKLYKVLSFLTVLTGWVRVCMAPVALFGFCYGKHTGQCIAHGIMGSAFILYSFVLSLVLVIPWIRKHQLLNTSDGGGGGGGATGTSQEFYDSTVMMVWGVVNTFTEHRWGRESWSMGDYQHTAMGIIWWGGGLLGMYLSRKNHRSFIPALLLIFTGYSMSQHAQHLIISTKVHSVFGISLMGAGITRIIEISFLLNDKSCHSSGQILSFQYLPPFCLTLAGVLFMGATEEQLQLVHDLGSDHSAYILVVSAAAFTIFLWIQLVIMFYLRLVGYNEDGELGQQQQHHHQYQSVDVEEFELGDLSEEEEEEEEEDQSGSTNNHHRELDTPPSSDDRNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEG6</accession>
    <name>A0A1D8PEG6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C108840WA</name>
        <name evidence="4" type="ordered locus">orf19.12204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723429.1">
        <property type="nucleotide sequence ID" value="XM_718336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEG6"/>
    <dbReference type="SMR" id="A0A1D8PEG6"/>
    <dbReference type="STRING" id="237561.A0A1D8PEG6"/>
    <dbReference type="GeneID" id="3634919"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108840WA"/>
    <dbReference type="CGD" id="CAL0000190331">
        <property type="gene designation" value="orf19.12204"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08840W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PEG6"/>
    <dbReference type="OMA" id="LRNDTDW"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:actin cortical patch"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:mating projection tip"/>
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    </dbReference>
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        <property type="term" value="C:medial cortex"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000190331"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="354" mass="41304" checksum="F30221FE4F987705" modified="2017-01-18" version="1">MSSEINKLSNLVSNHLKIVDKRITGNEQFHWNRLKRTPQILKQKIKFAGGSYTVDQTFNELDEELLVIDASIKKLIKYTKVFGESMNQVLSNSVCSAESFQNLIDPYTNLKSDSQILEDAYATWSKITKYKHKVKDVFVENEIDHLVSSVEKKLSEITKIYKAVFKKIELRKTALLDYDKVYNDHESLLLKQEQSELTLKQNNQLYSLERKLDDTKIRYTRINSLLVRELPLLIRLTQEVMGYVQAHIYYVHLTFCYQVAERIKETEFIENDVNKIVTDFMLMNDPIVQEIETYILTSHQAESNNDDNKTKESYCYALHDFAGQEESDLRFSKGDKIKILVGNGTWWEGQLNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEJ9</accession>
    <name>A0A1D8PEJ9_CANAL</name>
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        <recommendedName>
            <fullName evidence="17">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C108930CA</name>
        <name evidence="14" type="ordered locus">orf19.4751.1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330682.1">
        <property type="nucleotide sequence ID" value="XM_019475137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEJ9"/>
    <dbReference type="SMR" id="A0A1D8PEJ9"/>
    <dbReference type="STRING" id="237561.A0A1D8PEJ9"/>
    <dbReference type="GeneID" id="30515031"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108930CA"/>
    <dbReference type="CGD" id="CAL0000191606">
        <property type="gene designation" value="orf19.4751.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08930C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PEJ9"/>
    <dbReference type="OMA" id="VAFTAYC"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26530.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8558" checksum="934EBBA54EC09401" modified="2017-01-18" version="1">MQHSIIRLSQGTSSNGNPWAKRDAWRYQGQFTRFNRFKNAFPGLGIATVAFALYCGYEQLVLKKDDHHDEHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF67</accession>
    <name>A0A1D8PF67_CANAL</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="ordered locus">CAALFM_C111350CA</name>
        <name evidence="3" type="ordered locus">orf19.8285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_708708.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PF67"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PF67"/>
    <dbReference type="GeneID" id="3644548"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111350CA"/>
    <dbReference type="CGD" id="CAL0000194861">
        <property type="gene designation" value="TOS4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11350C_A"/>
    <dbReference type="eggNOG" id="ENOG502RZJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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            <end position="158"/>
        </location>
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            <end position="278"/>
        </location>
    </feature>
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        <location>
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            <end position="310"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="492" mass="55199" checksum="05F2E80D61C26741" modified="2017-01-18" version="1">MSNMNYQFPPSSPLLEDYSYNSSKDPFTSVASAKSKVAEEAAEARVSRDNYPTPNPSSSLFRSSSPAREAYGDNDVFRPEPKQTANINKDFNVLNPDKSVMRIPLVNTHTHFSIGRSSRSCEFALTASDPRISRVHLKLSSSSQQIILTCLGSNGVGVIIPKPCFVYETNSPDNFIIMENTTGKPLDAHLHNYKLNKTIKLDGNHTEFFVRKGETITMPKFENILLQISKDIILLNPNDIDEDLTDEETPTLLIENDNTNTNNTTPMNKTVSLTLPKTPLKPKPKSIIKVAENNNEEPDETPSKEQRSVENRTFVLFEDKNIPSRSTSTSPKPPAVLADKTNIKRKATSEEPQVKKKKKQIKRQQTPELDNSVLALPNLAEIQNILINHLAFSRLSSTPASFLNTISVSTSKLSLAQIRAILHDLKCIGVIHRQGKDAAGQPLQEEYYYMPENDEDRERTTLVSNIKGHGGLRSCRKTHKQYYWKKPAPIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFN6</accession>
    <name>A0A1D8PFN6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name evidence="16" type="ordered locus">CAALFM_C113580WA</name>
        <name evidence="15" type="ordered locus">orf19.12460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722199.2">
        <property type="nucleotide sequence ID" value="XM_717106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFN6"/>
    <dbReference type="SMR" id="A0A1D8PFN6"/>
    <dbReference type="FunCoup" id="A0A1D8PFN6">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFN6"/>
    <dbReference type="GeneID" id="3636208"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113580WA"/>
    <dbReference type="CGD" id="CAL0000188106">
        <property type="gene designation" value="SEC18"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13580W_A"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFN6"/>
    <dbReference type="OMA" id="CFDNEIA"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
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        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vesicular-fusion protein SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="49"/>
            <end position="128"/>
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        <location>
            <begin position="311"/>
            <end position="459"/>
        </location>
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    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="594"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367045"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01073"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000188106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="796" mass="89170" checksum="3724A7164849B9D9" modified="2017-01-18" version="1">MIMEKLGFHKVSNSPSSPSQPKITHNRPIPHPQSPPLPQRPLSEPLKKQLLVDNSPGNDVVIANCVAVNAQDFQNIPDRAPVILDGVFVYSIAKDDRVRPGTIGLAGNMRTWGKWSLGQPVNVENYNIFHNGQQQQYLGAIDLSIDFRAKARANSNPINHDELVALFLKNYENQILQPTQVIYMEYTGIYFQIRVNNVQIIDVNTKDQLPSFKDSDDINTKGILIKSTDVGFYPYEGSIINLTKPKTLKQRMFGGSTPHRTSRRKQIINPDFKLEDLGIGGLDAEFQDIFRRAFNSRILPPELAEKLDYKHCKGLLLYGPPGTGKTLIARKLSKMLNGKEPKIVNGPEMLSKYVGASEENIRNLFKDAEAEYKLKGEDSDLHVIIFDELDSVFKQRGSGKSDGTGVGDNVVNQLLSKMDGVDQLNNILVIGMTNRLDLIDTALLRPGRFEIQIEISLPDEKGRKDIFLIHTKKLTENGILSSDVNFDELSTLTKNFTGAEIEGLCNSAKSYAISRHTKKGALAQIDPESIAKMKITRDDFLLALNDIRPAFGTDEEDLSQQAQHGIIQFNQTIRNIFEKGQSIIDVVRSSETEHLRSILLYGPPGVGKTSIATTLALNSDFPFIKMLSAETLVGMGELRKIQEIDNVFRDVHKSPLNVLVIDKIENIINYNPIGPRFSNDILQVLMVYLTKKPPKGRRLLIIGTTSQYQVFKHMNLIDSFNDAIAVPPIKHIEEVGKVLDKLGFMNKSEREEILSQLSRYDINIGIKSLIDVLMVSKYSRDTVDEVVNNIVEKMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFX7</accession>
    <name>A0A1D8PFX7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C114430CA</name>
        <name evidence="5" type="ordered locus">orf19.7260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFX7"/>
    <dbReference type="SMR" id="A0A1D8PFX7"/>
    <dbReference type="STRING" id="237561.A0A1D8PFX7"/>
    <dbReference type="GeneID" id="3643297"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114430CA"/>
    <dbReference type="CGD" id="CAL0000175442">
        <property type="gene designation" value="orf19.7260"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14430C_A"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFX7"/>
    <dbReference type="OMA" id="YSHHPEY"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
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    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
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        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000175442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="259" mass="29189" checksum="BD6BA3AF11BAA7D8" modified="2017-01-18" version="1">MTLTTVSGDPITIGIGTGTSIKDLKRGQPTAENKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIAGFQREKLWITTKYSVTSSMIKKKSFTPTDFVEQALDEMNTNYIDLLLIHFPPKPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEALHSYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFY7</accession>
    <name>A0A1D8PFY7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C114560CA</name>
        <name evidence="2" type="ordered locus">orf19.7273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710028.2">
        <property type="nucleotide sequence ID" value="XM_704936.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFY7"/>
    <dbReference type="SMR" id="A0A1D8PFY7"/>
    <dbReference type="STRING" id="237561.A0A1D8PFY7"/>
    <dbReference type="GeneID" id="3648376"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114560CA"/>
    <dbReference type="CGD" id="CAL0000176110">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="8 9" key="2">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
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    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
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            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="528"/>
        </location>
    </feature>
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        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000196904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="625" mass="67445" checksum="217A838221589E4D" modified="2017-01-18" version="1">MSFKAGYHTISFLFILVSFVFLLFATISYPVVDIFALSKTSDNKYGIFGSCSTSNSDNCIVGYPLDFTGSIKDNSSGYLFMNDTRTTLAKIFVLAPIALGFDLILLIVIFVIHFGSRVTVLIGIFVNVLATIATIITCVVVILCFYPYVTWVPWTLVAAGAITFISLILLILSLTVVGNDDDDDDNDAKSNFDNEDFGRFTNYSRIDDKFNHIQTSTFKTSNSLDNDYEYKPHNNNNNNNNATTATTTNNVGSTNFTGGAMNKFSNPTNNSRGVMNGGSTTTGSGVGSGGTVISGMNPPAHKNGSLTSNSSSYYNNPQTATDFTQRNKPNAYQPSSLSGSGSNNGNTASSSLPYPPGTPIVDNNSNNSRNNYQPGVFDHHLGVEGHKPFTELDDDFDDDDEEDLANNRREIVNINDSDNDSDFTSVSQRPPNPQYYGSNSGSGTGYLPSNVVNQYSHVQQYQPIHQQGMPPPPQPPQQQQYRPTGQYSPSPNMGYNNTPMRSGGGVPPPGAGPGPGPVPVSGSYFPNQGPVPVPPQQQQQVRGPTISENVLNNNPDFQFSRGGQQQKRRVNPGFVPVAARYNNNNNNSTTGSSIGGPGNKNQNASALMGRRENTGPRSGPYGITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH31</accession>
    <name>A0A1D8PH31_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TATA-binding protein-associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">TAF14</name>
        <name evidence="9" type="ordered locus">CAALFM_C204220CA</name>
        <name evidence="8" type="ordered locus">orf19.8418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330769.1">
        <property type="nucleotide sequence ID" value="XM_019475224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH31"/>
    <dbReference type="SMR" id="A0A1D8PH31"/>
    <dbReference type="FunCoup" id="A0A1D8PH31">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH31"/>
    <dbReference type="GeneID" id="3637357"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204220CA"/>
    <dbReference type="CGD" id="CAL0000175425">
        <property type="gene designation" value="TAF14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04220C_A"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH31"/>
    <dbReference type="OMA" id="GEFDMTI"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900231">
        <property type="term" value="P:regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000005">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000006">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000175425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="263" mass="29068" checksum="CC12647D0A413E45" modified="2017-01-18" version="1">MSEVKRTIRITTEQHVLTDVPLVDNFPMRKWSVQISMLDSQGKEHPAKILDKVTYTLHPTFANPIRTLKQQPFRVEEQGWGEFDIPIAVHILGIPGKAGERKIQHDLNFLQEKYVNDHVISIPVSPTRNPALNKLLAETGSLPFEESGAGASSANSGSIGTKRKLESSNGATATAATSADNKSKKSKGAMKGNIDLEKLSQGLTKLSEDDLIVVVQMVTDNRTNEMNIKNDVDNGEFTMDLYTLPDSLLKSLWDYVKKHTGEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHA3</accession>
    <name>CYT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex catalytic subunit, mitochondrial</fullName>
            <ecNumber evidence="1">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CYT1</name>
        <name type="synonym">CYT12</name>
        <name type="ordered locus">CAALFM_C204950CA</name>
        <name type="ordered locus">orf19.11011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="1451" last="1469">
            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
            <authorList>
                <person name="Lan C.Y."/>
                <person name="Rodarte G."/>
                <person name="Murillo L.A."/>
                <person name="Jones T."/>
                <person name="Davis R.W."/>
                <person name="Dungan J."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="15387822"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="54" first="1335" last="1351">
            <title>Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p.</title>
            <authorList>
                <person name="Bensen E.S."/>
                <person name="Martin S.J."/>
                <person name="Li M."/>
                <person name="Berman J."/>
                <person name="Davis D.A."/>
            </authorList>
            <dbReference type="PubMed" id="15554973"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04350.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2023" name="Front. Cell. Infect. Microbiol." volume="13" first="1136698" last="1136698">
            <title>QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches.</title>
            <authorList>
                <person name="Zeng L."/>
                <person name="Huang Y."/>
                <person name="Tan J."/>
                <person name="Peng J."/>
                <person name="Hu N."/>
                <person name="Liu Q."/>
                <person name="Cao Y."/>
                <person name="Zhang Y."/>
                <person name="Chen J."/>
                <person name="Huang X."/>
            </authorList>
            <dbReference type="PubMed" id="36923588"/>
            <dbReference type="DOI" id="10.3389/fcimb.2023.1136698"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="15 16 17" key="9">
        <citation type="journal article" date="2022" name="Structure" volume="30" first="129" last="138.e4">
            <title>Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.</title>
            <authorList>
                <person name="Di Trani J.M."/>
                <person name="Liu Z."/>
                <person name="Whitesell L."/>
                <person name="Brzezinski P."/>
                <person name="Cowen L.E."/>
                <person name="Rubinstein J.L."/>
            </authorList>
            <dbReference type="PubMed" id="34525326"/>
            <dbReference type="DOI" id="10.1016/j.str.2021.08.006"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS) OF THE HOMODIMERIC RESPIRATORY COMPLEX III</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34525326, PubMed:36923588). The complex plays an important role in the uptake of multiple carbon sources present in different host niches (PubMed:36923588).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="1">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5 6 7 8">Expression is induced in high iron conditions (PubMed:15387822). Expression is repressed in alkaline conditions and during spider biofilm formation (PubMed:15554973, PubMed:22265407). Expression is also repressed by HAP43 (PubMed:21592964).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="10">Leads to lethality, showing that it is an essential gene.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714886.1">
        <property type="nucleotide sequence ID" value="XM_709793.2"/>
    </dbReference>
    <dbReference type="PDB" id="7RJA">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="D/N=1-288"/>
    </dbReference>
    <dbReference type="PDB" id="7RJB">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="D=1-288"/>
    </dbReference>
    <dbReference type="PDB" id="7RJC">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="D=1-288"/>
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    <dbReference type="PDB" id="7RJD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="D=1-288"/>
    </dbReference>
    <dbReference type="PDB" id="7RJE">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="D/N=1-288"/>
    </dbReference>
    <dbReference type="PDBsum" id="7RJA"/>
    <dbReference type="PDBsum" id="7RJB"/>
    <dbReference type="PDBsum" id="7RJC"/>
    <dbReference type="PDBsum" id="7RJD"/>
    <dbReference type="PDBsum" id="7RJE"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHA3"/>
    <dbReference type="EMDB" id="EMD-24482"/>
    <dbReference type="EMDB" id="EMD-24483"/>
    <dbReference type="EMDB" id="EMD-24484"/>
    <dbReference type="EMDB" id="EMD-24485"/>
    <dbReference type="EMDB" id="EMD-24486"/>
    <dbReference type="SMR" id="A0A1D8PHA3"/>
    <dbReference type="FunCoup" id="A0A1D8PHA3">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHA3"/>
    <dbReference type="EnsemblFungi" id="C2_04950C_A-T">
        <property type="protein sequence ID" value="C2_04950C_A-T-p1"/>
        <property type="gene ID" value="C2_04950C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643441"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204950CA"/>
    <dbReference type="CGD" id="CAL0000192434">
        <property type="gene designation" value="CYT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04950C_A"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHA3"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000459228" description="Cytochrome b-c1 complex catalytic subunit, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="3">
        <location>
            <begin position="69"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="98"/>
            <end position="100"/>
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    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="103"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="turn" evidence="19">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="143"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="166"/>
            <end position="168"/>
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    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="169"/>
            <end position="176"/>
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    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="202"/>
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        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="225"/>
            <end position="240"/>
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    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P07143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15387822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15554973"/>
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    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="34525326"/>
        </source>
    </evidence>
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        <source>
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        <scope>GENOME REANNOTATION</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="SMR" id="A0A1D8PI81"/>
    <dbReference type="FunCoup" id="A0A1D8PI81">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI81"/>
    <dbReference type="GeneID" id="3642335"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208080CA"/>
    <dbReference type="CGD" id="CAL0000200856">
        <property type="gene designation" value="IFM3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08080C_A"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI81"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="47"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000200856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="269" mass="29336" checksum="899DC9D0FE34712E" modified="2017-01-18" version="1">MPKTLVSLSHNGAGYDQIDVQPFTDKGIQVSNVTVPVEGPTAVTAVFLVLSCLRNYQEGHQILYDGGWDSKKCGGAKLGHSPEGKVVGILGMGGIGRAIRDRLKPFGFTKILYHNRKPLSSDLEGGAEYVSKEDLFKQADIICISVPLNAHTKHSINKEAISQMKDGVILINTARGAVIDEKELPELLKSGKIGAFGADVFEKEPEVSPELYRLPNVVSLPHMGTHTYEAIKDMEDWVAENVESCLKTGKVKTIVPEQYNLEIKQGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ29</accession>
    <name>A0A1D8PJ29_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">CHS8</name>
        <name evidence="14" type="ordered locus">CAALFM_C300710WA</name>
        <name evidence="13" type="ordered locus">orf19.12839</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717760.2">
        <property type="nucleotide sequence ID" value="XM_712667.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJ29"/>
    <dbReference type="STRING" id="237561.A0A1D8PJ29"/>
    <dbReference type="GeneID" id="3640532"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300710WA"/>
    <dbReference type="CGD" id="CAL0000191191">
        <property type="gene designation" value="CHS8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00710W_A"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJ29"/>
    <dbReference type="OMA" id="RYGAQPM"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="308"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000191191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1105" mass="125725" checksum="3A3B165EBC5A0F4F" modified="2017-01-18" version="1">MGNSNFNNKNSHNPFDNVSDDDDDLFDDIEPVQQGSPSQPQHHHIATNANNRYQFDNSPYRRSSSYDVYNNNPFVGNTSYTNTTTPPPMLQQQQQPALSPLQPPLFNNNGNNNTLYQQQQYKKYRTPTSSNSNSSYSTMVDNDEFQLSRKKTVAFTEPEYPPLTYSPGKKRDTATSTNVYDYDLEEMDDGSLVASGGSGGIHADFAGDDYIINPLQDADDDDSLDPFGDDESLFSDTGEEILRRGTTIKKRHSTRRGRRNGTLKRGKSRNTEYGGENEKLVNNDNGDEEDGDGDDDDDDFKPKLTYTKTIKKAKLINGNYVIDAPVPKTLLETYGKKINYHQDNVSREMSFVRYTAATCGPSNYVKFNYNLRQELYAPSRQTEIMICITMYNEDEVLLARTLKGVFENIRDLTNRSDPNWGDDSWKKIVVCIVNDGRLELNKRTETLLAALGIFQDGYAKSKINDKSVKAHIYEYTSTVGIDAVNDKVHLACNSTPVQFLFCLKEKNSRKINSHRWCFQAFAPILNPKVIMLLDCGTKPSRDAFFHLWKSFKDPNVAGACGEMRVALGPNKNLLMNPLVAAQNFEYKISNVLDKPMESVFGFISVLPGAFSAYRYEALLNVNGEGPLEKYFKGEYLHQMTTEGDSNDPDFDDERDVKEKNFQQAGIFTSNMYLAEDRILCFELVAKKNHNYILRYVNEAKAETDVPENIDEFVLQRRRWLNGSMFAAGYAVFHWTKIWRSNHSLFRKLFLQLEFYYQLVTILVSWFSLASFFLVFRILTANLGSSDMNFNVGKYLAIIFLWFYVGSVVCTFVLAFGNTPRGTRKFYLVIAVFFAILMAYMMFAAIFLAVHTVNSIVHNHKTDFTIALVFTNTKFRDLVVSMVSTYLLYFIGAFMYGEPSFMFTSFVQYVLLSPTYINVLNIYAFCNIHDVSWGTKGVEQAKDLGSAKSFGKNSDELVMIAPENLTQELNDKYVATLENLRTMIPVKDIPQESNKKKDDLAYYAFIRTITVLVWMLTNAILIAIVLEAGGVDILSGNKSGQTNADGSISGNSQVFLTIILWIVAGLALFRFIGAFLFLIFKSFRPLKWKLRAKRENKRNRNQNRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ99</accession>
    <name>A0A1D8PJ99_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C301740CA</name>
        <name evidence="2" type="ordered locus">orf19.1671.1</name>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="223"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000185001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="309" mass="34763" checksum="64D616BAC41D71F3" modified="2017-01-18" version="1">MTIKVAFLGPEGTYTHQALIQQFGTENVSIYPQQSIGDCFHILNEKKVDYAVVPFENSTNGQVVFTYDLLRDWYFQTSTPPKFRIIAEQFVSIHHNLLTNASKIEDIKTIYSHPQVWTQVNKFLQSLPQQITKIDVGSTSKAAEIVSQDTITTSGSSSAAISSYMSSELYKLPILKEGIEDNQSNTTRFLILGYDSPISPPPAAASNNDDDNSKRNTTIVSSIMFTLNHDDPGALCDVLVKFKEYGITLTSINSRPANLKPWQYVFFVEMIGDIHQEGLVEKIKESCLELVILGVFQRSWRYNNNSNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJQ9</accession>
    <name>A0A1D8PJQ9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAALFM_C303680WA</name>
        <name evidence="18" type="ordered locus">orf19.14213</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712752.1">
        <property type="nucleotide sequence ID" value="XM_707659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJQ9"/>
    <dbReference type="SMR" id="A0A1D8PJQ9"/>
    <dbReference type="FunCoup" id="A0A1D8PJQ9">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJQ9"/>
    <dbReference type="GeneID" id="3645648"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303680WA"/>
    <dbReference type="CGD" id="CAL0000198326">
        <property type="gene designation" value="orf19.14213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03680W_A"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJQ9"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000198326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW28396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="589" mass="64877" checksum="56B541D8464A8D81" modified="2017-01-18" version="1">MLELNSITIPRNFTEFQLTALKIYYQLKILFLATYCTQGSLGLNGSVCLARDIFVGYVVYTQLLKLYRVLRGYGIIDSIRRLYLYVSSIVSSQIFSLPFIKSKIDKELQATIGKVEEEIMKNDPQLLQFPELPEQGIDADNVSLELDKLQNLKHSDWINGRVSGAVYHGGENLLSLQVEAYKKYSVANQLHPDVFPGVRKMEAEVVHMVLDIFNAPSDGCGSTTSGGTESLLLAGLSAREYGKKYRGITEPEVIAPVTIHAGIEKACFYFGMKLHKVDLDPVTFQVDVKKVERLINSNTVLICGSAPNYPHGIIDDIESLSKLAVKYNIPLHVDACLGSFIVSFLEKSKVHGDRKLPIFDFRLPGVTSISCDTHKYGFAPKGSSIIMYRSPKLRECQYYIASDWTGGMYGSPTLAGSRPGALVVGCWATLINIGKQGYTKFCYDIVSASMKVKRAIETDPILSKHLQIIGDPIGSVISFQLAPQQSGNLSIYEISDLLTKKGWHFATLQNPSALHFAFTRLTVPVVDELIADLVEATKEAVAIAEEHKKNGVTKAPGDTAALYGIAGSVHTAGLADRLIVAFLDTLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKD3</accession>
    <name>A0A1D8PKD3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">NOG1</name>
        <name evidence="12" type="ordered locus">CAALFM_C306030WA</name>
        <name evidence="11" type="ordered locus">orf19.7384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1 8">Involved in the biogenesis of the 60S ribosomal subunit.</text>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000186790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="838" mass="93338" checksum="7383204FC8B42DEC" modified="2017-01-18" version="1">MSSKPTKKPSGEPEKSKREDRDKPTFNKDASPFSPSEYSQPSDPSELTYQPPPSPFQASKPLIRKSTTNASPTSSYASTASYEVILNNIPNSISQNDLHQFIDSCIKEDHFHIIEFNKGSTNTSSNSNTTTTAVLKITNLLTYHKIKTNLSQAELEGNIIEVKLKETDTPHSSSASPVPDPHFNPQFVPPLQAFPYWRQVPFSHRNSSSSISTSQRVPSSSSNRTSVDSRRTSSKTSNSTQSSISSMGTSQRSSTASSVGNDLSFPKKPAPPFMLRMAQNRDRNTSSPESFVSNTEDSQSDTIVQSEQYRRSEGPESGQGPGPGQGQEPKLEQIKEKEKDKEDVGDENEYEDEYILIRSGDGENPDEVIKVNPKRLFIGNVPYNSTWTSLKNFLITKSLELEPDNNISIHRVEIPTQQILRHDPYFLYHQHRGQMVGGPTFINKSRGFAIVRTGDRESSEKLIQMFDNVEFEGRLLTVRFDRYPDFNNYTVQQMYGGGGNNSSNSINSGVGRMFPMPPQFPIQQQFYPHSPTLDRSNTRHHMSQTPLPLPQPYQQQHHHQQQRPQQQQPSSPSVLSSLAFEKNSYQHNLYYGSTGTGMPSASVPPPGAVPPLPPPGAIHPSYGQAMMSPNAIAQSARTGTVESPRYQQYQYLQGILPTGYQQSEVASSGEQNSPFVQGFFCMPQPYFNSPGTGQASAAAMYVPIQYHYNSRSLSQYNNYQQQQYTQQTPLTMHALPPPPPLQPPPPQQQQQHAQSPPPPPPQPPQQRAKQNKSSTYLAKSRNVSKESTPMTSETKQKQSDITEPVTTTTADNREPTSTASEEEKARELMNSIKDLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLL7</accession>
    <name>A0A1D8PLL7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C402580WA</name>
        <name evidence="5" type="ordered locus">CAALFM_C402680CA</name>
        <name evidence="3" type="ordered locus">orf19.10245</name>
        <name evidence="2" type="ordered locus">orf19.10256</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314</strain>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2016-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Candida Genome Database"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">SC5314</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">SC5314</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720481.2">
        <property type="nucleotide sequence ID" value="XM_715388.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720492.2">
        <property type="nucleotide sequence ID" value="XM_715399.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLL7"/>
    <dbReference type="GeneID" id="3637828"/>
    <dbReference type="GeneID" id="3637915"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402580WA"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402680CA"/>
    <dbReference type="CGD" id="CAL0000197929">
        <property type="gene designation" value="orf19.10245"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000192147">
        <property type="gene designation" value="orf19.10256"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02580W_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02680C_A"/>
    <dbReference type="OrthoDB" id="4086878at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000197929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="112" mass="12848" checksum="DD99DF7815C25508" modified="2017-01-18" version="1">MLCHFSSLHYPHTSMPTQRTSRPATHEQISKSRVVNASILTFLTVLIFLILLYHFIWAVQVMMYQPYGNLLNNIVYGPGTLIANAGLSSKLIKYINTKLVEDKIEADYKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLT6</accession>
    <name>A0A1D8PLT6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial 54S ribosomal protein YmL22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C403410WA</name>
        <name evidence="6" type="ordered locus">orf19.10875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711587.2">
        <property type="nucleotide sequence ID" value="XM_706495.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLT6"/>
    <dbReference type="SMR" id="A0A1D8PLT6"/>
    <dbReference type="FunCoup" id="A0A1D8PLT6">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLT6"/>
    <dbReference type="GeneID" id="3646807"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403410WA"/>
    <dbReference type="CGD" id="CAL0000174039">
        <property type="gene designation" value="orf19.10875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03410W_A"/>
    <dbReference type="eggNOG" id="KOG1711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLT6"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000022">
        <property type="entry name" value="Mitochondrial ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000174039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="291" mass="34374" checksum="DEFA666C61C528F5" modified="2017-01-18" version="1">MNKFSIITRPLFRSSRHIGVFVPIQRFFSTTSPRLSNLLGEVTKIDSEPPITTTSKSTTTSSSEDNKDISKITPENDEELIEYHAKNAESKQFKIEKYIHPLKLQLYNENISQFGFFKNGQIMNHNGKKLRFTLTPQEIDILEPSIYLTSYRIKSSMKKATIVNRMVRKFNVKLAINQLHFNHKKISTELEQLLKRGLEQAKQLELNEDELYIDRIWVGSDGKWRKRLDPKGRGRMGIIAHRYVHLKCILKTNQTKLRLDWEKQQKELKSKPRMFLNDEPLNLKVRPWYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM95</accession>
    <name>A0A1D8PM95_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hap41p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">HAP41</name>
        <name evidence="5" type="ordered locus">CAALFM_C405110CA</name>
        <name evidence="4" type="ordered locus">orf19.8359</name>
    </gene>
    <organism evidence="5 6">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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                <person name="Dungan J."/>
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            </authorList>
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    </reference>
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                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_720651.2">
        <property type="nucleotide sequence ID" value="XM_715558.2"/>
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        <property type="interactions" value="113"/>
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    <dbReference type="STRING" id="237561.A0A1D8PNM2"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C503140CA"/>
    <dbReference type="CGD" id="CAL0000190809">
        <property type="gene designation" value="orf19.11823"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03140C_A"/>
    <dbReference type="eggNOG" id="KOG1913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNM2"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="823"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="947"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1287"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1478"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1853"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1947"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
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            <begin position="149"/>
            <end position="163"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="374"/>
            <end position="387"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="619"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="1302"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1640"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1725"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1862"/>
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        </location>
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        <location>
            <begin position="1884"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1897"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1971"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1984"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2002"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2028"/>
            <end position="2042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000190809"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2091" mass="226009" checksum="5164712D8B9BED2E" modified="2017-01-18" version="1">MSELSNDNIVESQELSSPVTREEPVANDSNDLFGGDDQSTSNQQDDFFSNIQQPDQPDQPIIETNEELETVHKSTDVELPQEIPLEQEQIPQQPQQQENVIDDLFGTSNNDDDFFSNHNQDGLNSAEIETEENVEVPLQPDFEQNQDLESEKATISIDKKDEDPVLESLTTESDILDNDHESTSEAPGISTESEVFEEEAVVEEVQSTAEDSPVDATQPSELGPLSTEQINLVDEPEAGAPNTEESQTESKLDQFFTESNEGDFFENIARDNVEQEVSNPSKTEADQKLEDLFAGADNENGEDLDFLQQPQHNVAEVNSEAAVATESINLDLFGEDDTDFLDELNSKKQQQQEEEVGPSSTSTTNPEDKLAALDLDDDLLLDDDFLEEGSVQPKVESSLPENKPVKHHHSYIPSGPSANQKSVYAPPQVSGVNKNDFIKNLEQSKKKHDAYDFPDTLLVNKSRPAARHAPSSNKYGPPSVSQTSIPSISSTSSLPPARDVKSSSSAPPAAAPPTGTSTSKVAKKSFFEDFPDDEEIPKPKRAGRAAAPVKAVNQIHSPQVLNQQVQQQQQQQQSQQNAPPAPPPSKVNKQPPVNPYMPKSGTSPILQQQTPAVHKSGIAAPNVNVPHANNYAPPLNSFAFPPRQPNQKTNDYSPQLQSSPAPPPPPTSLQPFPSIGQSQSAPVYHNRQPSNSINTNVNKVPSINSPYVPNAGPYAPSTHQRSHSRASSLVGGKGKEVNPYAPALETVASGDINQIQQQQQQQQHLSPATAVLPPARARGFSNAKSNIYKSAPKVVNPEQLVFRQYPIFSFSINSNCSVIIPNTGYNQGTSINIGPISNLLKDKDLYATFPGPLSKSKSKKKDVEKWLESSSGYLRSLGKNDELVLNDILLHLIKHDGDVKNQEFLRSACSILNPNVNFDVNNLPTSGLAIGATNAHKLDNSGINTVFTLIQSGNLEKALEYCVSRGDWALALIISGPENFNKIAAEYARNTFPFAKTNNKVLHIMPIILKVLGGNVSSVIEDLTAVPNEGEYANLHWREIISTIAICGSLKATEFLIEFGKFLNQQGNFIGSEIAYIMAGLPFGHQNFMMLASGHNSMYTEVYEYALNLHKAMHFPHLLSLKLKHALTLADYGLINESQRYIDHINSSIKTLGNKSPFVTPNLLHEFQNLIMRITEVGSGDDQNNWFSGKISRVNLDKIWGQIDKFIVGGDESKNGNNNDGNGTGNGSGSVFNKFSPSVSRNASSVNLHNYAQPSMIRQPSLLPYQPQQQPQPQQQLLDQVHIERKPTTGFAPQPPPLVGHPSTTSVNKYSPSIKSSPRQAQQNKFEKYAPSNNSSHHNLSLVEERSAVTSADGPEYPHHQHQQSINASAVPVPLPPPTPPVSMPQHVSRSPRSHQSHQPPTLPPSHSHHVQQPSRDRSPLATRIYPYSNSVGGQISTTSVGSIPSQIPLGRQTHGKQPSISSVISGDSIAAVGLGEQENILPPSTGQTGKTATSEVNRNEEGYGFGGHYHHDQPETITESPELRGLQQPQSSEAEISKDISNDVALDSAKIPEASQEPEEETDESGNVAAAPPPPPVAPVAPPRKTKSSRSNPYAPSTDIGATSNAPSAVGQTLGGKPSMRKSGSRTNRYGPPPGVGNKQPTIDVSPPSATNNTGNEDSISMFSYGGYQNESSPPLKQPSQFDQTAVASAPAPPPLQPQLAVPERVPTKNVANIDDSFDENSLAADTSTTYNNNMVNKPYGSSPMGPTVATNGPGSVTSTPLILNQGSANMKLSNLSTISVTGTGTGTGTGGAFDGFPIPGSPDETTRPNSIFGGHTRGLFSSRLSESQSVLYQQYAIADDTVGDYIPIMEEDDEDDEDEQAKQQKQKEKEAQEQELKRKQEQQQQKAAAKNNNNSGGGGGKFFSLFGGGGNNKKQDNDAKVYKAHLGQKNTFVYDEKLKRWIDKSKPLEEQLQANLPPPPPPSMKKKPNPVSTTTNSNNSSGPPPMVTPNPTPIPGGDLSTTTTGGISTPIPASAPPSRMSKDTTKPTPSINRPKSSLATASGLDDLLSLTDNNPPPNGRSRGVGGGATPGGSRRNKPKRRGYVNVMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNV9</accession>
    <name>A0A1D8PNV9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">CDS1</name>
        <name evidence="20" type="ordered locus">CAALFM_C504100WA</name>
        <name evidence="19" type="ordered locus">orf19.8866</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710660.2">
        <property type="nucleotide sequence ID" value="XM_705568.2"/>
    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C504100WA"/>
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        <property type="gene designation" value="CDS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04100W_A"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="reaction ID" value="UER00614"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
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        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
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        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
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            <dbReference type="ARBA" id="ARBA00012487"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000174872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="451" mass="51257" checksum="553B9BE62B1D10D3" modified="2017-01-18" version="1">MISNGKDTSLKQVEAEVSTKSTSITPTKNELFNSTSKPTPTNDKSTEQTKEQLVVNEKEKKKQAFVTRTIWTFVMIGGFFAILASGHLALIIMVSVFQMLTFKEVIALTSEPARDKKIPWNRSLNWYFLGTTWYYLDFPALFDFFQESVYSSKFLTLLVKNHKFISYSLYIAGFVFFVWTLKKGYYRFQFAQLCVTHMTLLLVVFQAHLIIDNILQGIIWFFLPATLVIVNDIFAYLCGITFGRTQLIEISPKKTVEGFVGAWICTGIAGVIASHILSKSDYMICPAENLSTHLYNFPHCDLNPIYIPQVYQLPANIVELTGHELITFKPFYFHAAILATFASLIAPFGGFFASGLKRAFGIKDFGDTIPGHGGITDRFDCQFLMGSFTYLYYHTFVSNQNVNLGHVLQLAIMNLSVPQLLQLIKSLLKYLNREEVLTSEQLSRIFDILEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP40</accession>
    <name>A0A1D8PP40_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C505000CA</name>
        <name evidence="4" type="ordered locus">orf19.11474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721899.2">
        <property type="nucleotide sequence ID" value="XM_716806.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP40"/>
    <dbReference type="FunCoup" id="A0A1D8PP40">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP40"/>
    <dbReference type="ESTHER" id="canal-q5ak29">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="GeneID" id="3636539"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505000CA"/>
    <dbReference type="CGD" id="CAL0000186337">
        <property type="gene designation" value="orf19.11474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05000C_A"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP40"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="192"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000186337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="733" mass="82988" checksum="ED8F03C7244EF39B" modified="2017-01-18" version="1">MTKEQLDNIEHKILYRQVKSVKAGDIERFKIHFTPHAEGDEVIIPPTLWVKIRNTEPVSKRAIYLAGPYILYVDCRSSDYDPNVKYFVTADQPVFEPQLLAGQSFYIQLSCHTLKKDYSWIVDVVPQIIFNNTISIDFEIMIGTSKQILHEASFPEKSVPLSDKIGCFNELLHVYNWDTLDLWNLPVMSPDKPKHLVILTHGLHSNASSDMLYLKEQIDRIAELRNDNEEIVVKGYFGNIGKTERGIKYLGSRVAEFIIDLVTENESFNNGKVKKISFVGHSLGGCVQTFAIAYLKVNFPWFFDVIKPINFITLASPLLGVVNENPLVVKWVLSAGFVGNTGQELGLKYLENGAKPLLLLLPAGPTHEVLKKFIRRTVYANAINDGIVPLRTSSLMFLDYKGLAEIINSEELAQSDETGKIPESVESANKFSAVQTFLSYLMPQKQTSQEYRRFQTQDDKVVEDHKSDGKAIPNSTFLDSAASLILPPLPSMKYIVDPSTRENVIIHDKVYYEKDLPERDLDVELDSFEWLEEEIAREYHKNMGWRKVVVKIKPDAHNNIIVRRRFANAYGWPVIQHLVENHFGPNRTVDSKMIDSAIVDSVSTNSLDEENGLTRIISRDLISRQNKEIDDNVSEEQRPEEYPHEWINSEHNGDSVFAVGVTGLLGEVADMVGGFRDQITKYSLNPPSLPIIGEIPFPAALMAPTDTNNGNTKSEEELNKDLKLSNGIMNDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP79</accession>
    <name>A0A1D8PP79_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C505340WA</name>
        <name evidence="5" type="ordered locus">orf19.11512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="9 10" key="2">
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
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        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713991.2"/>
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    <dbReference type="eggNOG" id="KOG2770">
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
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        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
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            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000177615"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="394" mass="43768" checksum="1C68DD7C90E6E181" modified="2017-01-18" version="1">MLRITSKRLYSSTSNLLKTPLHEAHIELGGKMVPYAGFEMPVLYKGQSHIESHNWVRSKVGLFDVSHMLQHNISGKDAQSLLQKITPIDLSKLPVNTSSLSVLLNNNGGVIDDCIITKHGEDEYYMVTNAGCREKDVKFIKDEASQFNSVNHNTFEGTLLAIQGPKAQEILQQFTNEDLSKIYFGQTKFLKLSPIGATVYLARSGYTGEDGFELSIPSTTPEESKQALDFFYTLINEYPDVVKPIGLAARDSLRLEAGMCLYGHELTEEITPIEASLTWLIPKTRRDENNDFNGASKILSQIKDKSSFTHRRIGLTSKGPSPRDGNKIFNEDGTVEIGYVTSGSPSPTLGGNIAQAYIDKKHKIGSNVKIEIRNKLRDAVITKLPFVPSNLYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ32</accession>
    <name>A0A1D8PQ32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C603150CA</name>
        <name evidence="2" type="ordered locus">orf19.13044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PQ32"/>
    <dbReference type="STRING" id="237561.A0A1D8PQ32"/>
    <dbReference type="GeneID" id="3639257"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603150CA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="407" mass="46563" checksum="B3AC97F53CE795D0" modified="2017-01-18" version="1">MLQPLLKRRLSLYPWRHVYARNYSNKQSQNAEPASEQEVTSAIVDRMKQILEEKISSQSASTIQTMKRTDESLNQILSKYDTPSTSLPNSKQASSYIRSEPILAHNKHAKDIYNSIPWSGAESVYDSNLRMIVDSKPKPINDPASIAYKKRNPTKNEKLAMARDISLDYKVNKPQGGKNKDTDDDGFREMYRERLLGPSMLLNHSSTSVDFVEMLAGNKINAKIDQTTGKFETDDMQKVRGKPLEKQHLVNCTDSNYFMNQVLNKQEVLPPWIESQQNLNRNIAQFREDLVEMWSKSKKLHESDLKYIETKINLLNQEIRNYNLQCPSVSGHKFKLDKEKEIEQAFKKALENPRKPKPIEDKTTSGFLDIFGGGGGAGVRQSIHIDRNSDPKLNVWQAIKDVFSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQD9</accession>
    <name>A0A1D8PQD9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C604260CA</name>
        <name evidence="5" type="ordered locus">orf19.8684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Dungan J."/>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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        <scope>GENOME REANNOTATION</scope>
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    <reference evidence="4 5" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PR13"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C7_02090C_A"/>
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    <dbReference type="Proteomes" id="UP000000559">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF11704">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="75"/>
            <end position="266"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000186966"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="266" mass="29752" checksum="0201C5C3A0B89B4B" modified="2017-01-18" version="1">MVCLAHFCELHGPSVIACTQIIDERSVKENSLSANSRSASCLSCQFILPDSTANLVTKLTKDNEKKPANLHKSASPIPTLTPTSTPTPTDLILEKVSISTHYPSSQKRYSALTKLVMKSLSVETMSDLSKPMFYGDAINGYCINQIFKVEDLNARGGERKYSLMVISDNESELLMRWEIVSIYFNVVIELIQKKVAKANQVKQSESNNSSNNFGDGDSSTNKMFDNERYLRRSLIKPKSLTELTNDNEIFVRIHLCVTEMLKDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRU0</accession>
    <name>A0A1D8PRU0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR00650WA</name>
        <name evidence="10" type="ordered locus">orf19.7464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718622.1">
        <property type="nucleotide sequence ID" value="XM_713529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRU0"/>
    <dbReference type="SMR" id="A0A1D8PRU0"/>
    <dbReference type="FunCoup" id="A0A1D8PRU0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="3639659"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00650WA"/>
    <dbReference type="CGD" id="CAL0000200961">
        <property type="gene designation" value="orf19.7464"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00650W_A"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRU0"/>
    <dbReference type="OMA" id="GRMGVAN"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF13">
        <property type="entry name" value="SUBTILASE-TYPE PROTEINASE RRT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111243" description="Peptidase S8/S53 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="134"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000200961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41041" checksum="CD1C328302632B15" modified="2017-01-18" version="1">MVKLLLSIWISIYFMAGSSFASSSYLVSLHSQETIDTFMAYDATYPQDLQVGELINSKFKIGNFSGFSGSFSKDIIKRLERCPLVDEIVPDITVKAYDAVFQDSAPRHLARISRRKRMKPIKKYSYIYESDFIGKKVSAYVIDSGIAIGHPEFQGRARTGKDFTDEGPGDNNGHGTHVAGLIGSHTYGVAKGVQIIDVKALNSKGTGSLSTILVAIEFAVNHRLRSGRMGVANLSLGAYKNKLLNKAIDQATQTGLVFVVAAGNNNINACLTSPSSSPYAITVGAIDDYNDSIASFSNWGECVDLFASGAYVKSVNIRSDFRPSVLSGTSMAAPIVTGLVANLLNEGVDPELIKGQLIEMSTKHRISKSSLFLKKRTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS23</accession>
    <name>A0A1D8PS23_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">25S rRNA (Uracil2843-N3)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR01780WA</name>
        <name evidence="2" type="ordered locus">orf19.10107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718241.2">
        <property type="nucleotide sequence ID" value="XM_713148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS23"/>
    <dbReference type="FunCoup" id="A0A1D8PS23">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS23"/>
    <dbReference type="GeneID" id="3640157"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01780WA"/>
    <dbReference type="CGD" id="CAL0000181125">
        <property type="gene designation" value="orf19.10107"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01780W_A"/>
    <dbReference type="eggNOG" id="ENOG502QR34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS23"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000181125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="319" mass="36420" checksum="FF3CD8AC6D36BA75" modified="2017-01-18" version="1">MSRKPRRHNETKSTPDNGSDGIDLFPFTTEDCMEPQKIIDLFEVCFKHVLESPDLQEHIQVVKGDLYNRDYLAAFNNDDNRFAYACRWSPARALAYSSVLASLEPIKTLLEDPETVRNVLCVGGGASSELVALGSVFCRLKEYHPNSPSQLNIKLIDIADWSKVVSNLTTYMKDSWVYHSEKLNSQFICDDILTSSPESLNLESLDLITLLFTTNELFAEKRKETIKFLQLLNSNCRQGSLLLIAESAGSYSHIKIGDKNFPVQFLIDTILVGKPGSNNGSWEIISQSDSSWYRINQKEVDYPMKLENMRFFYRLYIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS61</accession>
    <name>A0A1D8PS61_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Opt3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">OPT3</name>
        <name evidence="11" type="ordered locus">CAALFM_CR02220CA</name>
        <name evidence="10" type="ordered locus">orf19.3749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713437.1">
        <property type="nucleotide sequence ID" value="XM_708344.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS61"/>
    <dbReference type="FunCoup" id="A0A1D8PS61">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS61"/>
    <dbReference type="GeneID" id="3644918"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02220CA"/>
    <dbReference type="CGD" id="CAL0000185426">
        <property type="gene designation" value="OPT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02220C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PS61"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="810"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="838"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000185426"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT27</accession>
    <name>A0A1D8PT27_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">ACO2</name>
        <name evidence="13" type="ordered locus">CAALFM_CR05790CA</name>
        <name evidence="12" type="ordered locus">orf19.13953</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711698.2">
        <property type="nucleotide sequence ID" value="XM_706606.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT27"/>
    <dbReference type="SMR" id="A0A1D8PT27"/>
    <dbReference type="FunCoup" id="A0A1D8PT27">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PT27"/>
    <dbReference type="GeneID" id="3646708"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05790CA"/>
    <dbReference type="CGD" id="CAL0000193227">
        <property type="gene designation" value="ACO2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05790C_A"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT27"/>
    <dbReference type="OMA" id="KWPETFG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="61"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="589"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000193227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="791" mass="85925" checksum="3229070D863DE66E" modified="2017-01-18" version="1">MLRARSVLSGSVSRRALATQAFNFSVPPEYQSRTPPYSKLINNLSTVKKILKNQPLTLAEKILYSHLCNPEESLTSSNVSDIRGQQYLKLHPDRVAMQDASAQMALLQFMTCGMSSTAVPASIHCDHLIVGKDGAEEDLVKSIATNKEVFDFLQSCGEKYGIQFWGPGSGIIHQIVLENFAAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGQLSGWSSPKDVITTLAGILTVRGGTGYIVEYFGDGVKTLSCTGMATICNMGAEIGATTSTFPYQEAHKRYLIDTHRAPIAEAADSVNSEFKFLQADEGAEYDKVIEINLSELEPHVNGPFTPDLSTPISKFGETAQKEGWPETVSAGLIGSCTNSSYQDMSRAVSIIKQAEAVGLKPKIPFFVTPGSEQIRATIERDGLINTFESNGAIVLANACGPCIGQWDRTDVPKTSTDFNAIFTSFNRNFRARNDGNRNTMNFLTSPDMVTAMIYSGDMNFNPVTDSIELPNGKEFRFQPPQGKDLPQSGFIPGRSEFYPEANPQPKPEVEVNVSPSSDRLQLLEPFQPWSGEELSTTVLLKVEGKCTTDHISAAGVWLKYKGHLENISYNTLIGAVNKETGEVNKAYDLNGDAYGIPELMIKWKDESRPWVVVAEHNYGEGSAREHAALSPRFLGGSVILVKSFARIHETNLKKQGMLPLTFADEADYDKISSGDLLTTIDLKDMIAKDGNNGGTLRVKVTKRDGSEFEILAKHTMSKDQVEFFKAGSAINYIGNTKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT56</accession>
    <name>A0A1D8PT56_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">ADE13</name>
        <name evidence="15" type="ordered locus">CAALFM_CR06150CA</name>
        <name evidence="14" type="ordered locus">orf19.11351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2017-04" db="PDB data bank">
            <title>Crystal structure of adenylosuccinate lyase ADE13 from Candida albicans.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH CA(2+) AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713495.1">
        <property type="nucleotide sequence ID" value="XM_708402.1"/>
    </dbReference>
    <dbReference type="PDB" id="5VKW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-482"/>
    </dbReference>
    <dbReference type="PDBsum" id="5VKW"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT56"/>
    <dbReference type="SMR" id="A0A1D8PT56"/>
    <dbReference type="FunCoup" id="A0A1D8PT56">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PT56"/>
    <dbReference type="GeneID" id="3644863"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06150CA"/>
    <dbReference type="CGD" id="CAL0000175023">
        <property type="gene designation" value="ADE13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06150C_A"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT56"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000175023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW31325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5VKW"/>
        </source>
    </evidence>
    <sequence length="482" mass="54440" checksum="14CCC61002720FA4" modified="2017-01-18" version="1">MSEYDKYSTPLSSRYASEEMSKIFSLRNRFSTWRKLWLNLAIAEKEVGLSVITDEAIEQMKQHLEITDKEIQDAAVEEAKVRHDVMAHVHVFGETCPSAAGIIHLGATSCFVTDNADLIFLRDAYDVLIPKLVNVIDRLSKFALEYKDLPVLGWTHFQPAQLTTVGKRATLWLQELLWDLRNMVRARNDIGLRGVKGTTGTQASFLSLFHGDHDKVEELDKRVVELLGFDIVYPVTGQTYSRKIDIDVLSPLASFGATAHKFATDIRLLANLKEIEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGGLFNDAVQTASVQWFERTLDDSAIRRISLPSAFLTVDILLSTMLNITSGLVVYPKVIERRINSELPFMATENIIMAMVEKGGSRQDCHEEIRVLSHQASAVVKQEGGDNDLIERIKSTEYFKPIWNDLDTLLDPKTFVGRAPQQTEKFVKNDVANALKPFEKYITTENVALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT67</accession>
    <name>A0A1D8PT67_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR06260WA</name>
        <name evidence="2" type="ordered locus">orf19.11359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713503.2">
        <property type="nucleotide sequence ID" value="XM_708410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT67"/>
    <dbReference type="STRING" id="237561.A0A1D8PT67"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PT67"/>
    <dbReference type="GeneID" id="3644853"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06260WA"/>
    <dbReference type="CGD" id="CAL0000177439">
        <property type="gene designation" value="orf19.11359"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06260W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PT67"/>
    <dbReference type="OrthoDB" id="4021105at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000177439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="390" mass="44544" checksum="1F26321EB5F56F7D" modified="2017-01-18" version="1">MLERFEYDGNGFIDPESFKTPLLIFPPNLNALSIRCRDFINIDLSTLMLPPTLIRLELLDLSFNDGYFHLGENLQYVHIETSTLTFDSSFRIPHLAGELILEADYLTFESPEFMYHLPNSLTRLQLIANKQGKMSPFIRKIRWPLVLGDFAFKNFSIDYHTLELLNLKESRLEVIYIRGGNIKKLNVDLFPVSVKNLTLMEMGIHELSASFASLMNLRRLSIMRNRLKRVSSVELPVSSLEVLDLSQCNLRLISPFLVSMFEKKSENPRLRIDATGNLNVNVIDVRRVLKAIKGLSLDLNSFDETLRKIAQQSSRLCCIFETFDPYSDEAESSGTSEVVPDYDSDDLYNGSVFTSDEEDSDEDDYSRRPNVIVEALGLLSDYDDGDDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT88</accession>
    <name>A0A1D8PT88_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">KIP1</name>
        <name evidence="15" type="ordered locus">CAALFM_CR06540WA</name>
        <name evidence="14" type="ordered locus">orf19.8331</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713072.2">
        <property type="nucleotide sequence ID" value="XM_707979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT88"/>
    <dbReference type="SMR" id="A0A1D8PT88"/>
    <dbReference type="FunCoup" id="A0A1D8PT88">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PT88"/>
    <dbReference type="GeneID" id="3645261"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06540WA"/>
    <dbReference type="CGD" id="CAL0000181692">
        <property type="gene designation" value="KIP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06540W_A"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT88"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000246">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="3"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="851"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="451"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="866"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000181692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="911" mass="102876" checksum="450BA30390DB63B5" modified="2017-01-18" version="1">MSNIQVVVRCRGRNSQEIAAKSPIVVELTNDNYSITEPYITINQGYTRATATTTTNNTTTTNSNNTAGATPNTSASSLDTNSKRTYKFDQIYGSQADQNLIYSQIAHPLLLDFLRGINVTVLAYGQTGTGKTYTMSGMDNNNKLDENSDIAGIIPRLLGELFQNLSSNATSKNDYMVKISYLEIYNEELIDLLSNNNSNNRKLRIHEKTNANKVKSIGIQNLTEYTINNYNQGIKYLKMGLQKKKTSSTNLNETSSRSHTIFSVQLYQKISSSSSSSSENDNEESVYRISKMNLVDLAGSENISRSGSIVKEAGGINQSLLTLGRVINSLNEKKLSHIPYRESKLTHILQDSLGGNTKTTLIATISPAQVNLSETCSTLDYASKAKNIKNAPMIGHDSEIIMKKTLVKNLAQELTLLNMDLIATRNKNGVYLDPENYDQLIQENESLKTGAKEDRLKLESLQAKIETLEFTKLEAKEEIDNLKQQLQSYQSKLQILETKYHKAVGLNQTNQETICELNNKLKQAFEKSSSSAELLVNLLSNHLHTSIGLVNESRNLQQDNKSVDQLTNFQLEFTKNLDEYKQQLETNLQNYQSQVGNIVNEDLTNYISTFQKNFDNLLTFQQEFYNKTFEVIQDFKIINEKLSGFLKDDYLHNIETNLNSQLGNILGENLPILVDNFKKIMTKELKTTMNNVMDKYKTVSNEEISKERENVLKMENSWNSQINCLLPKLETDLNNNNKFHHDCQTNLQKFINNNDICERINKFQQDNNSQLDKINPFDLKPKLTSSINGITNDIQQYHNQMNNNLTKINQELTQIQQFDANTMKISPIKESSRIPITTANMPNNQFKPIKLHRSNTACGGGGATGKSPSPTRIPTLQRSKSNVPEDTSPQDSTTTNNNKKRKILQTMDNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTA4</accession>
    <name>A0A1D8PTA4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">SEO1</name>
        <name evidence="9" type="ordered locus">CAALFM_CR06660WA</name>
        <name evidence="8" type="ordered locus">orf19.8319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_706681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTA4"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTA4"/>
    <dbReference type="GeneID" id="3646621"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06660WA"/>
    <dbReference type="CGD" id="CAL0000177585">
        <property type="gene designation" value="SEO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06660W_A"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTA4"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="AFR578Cp"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000177585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="609" mass="69602" checksum="86AAB5BC953AF6E6" modified="2017-01-18" version="1">MSFFTEPISRLKWGIFPTRRIVDEDEHGNFIDPDTIIADSSLAPPSSDDVASSDEHSGSQEKLESKEATQLISTTTTTPKATPVVLEYRDEKNRPWWKFFDEYEYRVTSNVKSKRKWYKWFHEDDTPEERRVIMKIDILLTLYSLAAYFVKYLDQSNLTNAYIGGMQEGLGMKGNDFVNTGVMFSVGNIIFQIPFMYIVYALPLNYVLPALDLGWSILTICLYRSGNVHGLKALRFFIGAFEAPSYLAYHALFASWFKGSTGEIARRAGFYYLGQYLGVLTSGLLSGAIVRHLDGAAGHAAWQWIFIIDGIISVVIGIIGFYMIPGTPQDCYSIFLSDEEIRIARRRMKADQKDSKPRENAVKYFFNKDIWKKIFSSWHFYVLSLWNIFCWNNSNAGSGAYALWLRTLKDSAGNLRFTGGKLQDYTALTPGLGLIWLILASTFADLLGSRWGAILFTQVFNILGNVLLAVWHIPERAKWFAWCMQYFGWAMAPVLYSWQGDICRRDIRERQVVLVSMNILAQQSTAWIAVLVWKTVEAPRFLKGYTFTACSAFALSVWTMVVLWLYKREERENARANGIILYDSSKEDLEQVQVQLQAEANSINSKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTP9</accession>
    <name>A0A1D8PTP9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chaperone ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">HSP104</name>
        <name evidence="16" type="ordered locus">CAALFM_CR08250CA</name>
        <name evidence="15" type="ordered locus">orf19.13747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="Acta Crystallogr. D Struct. Biol." volume="73" first="365" last="372">
            <title>Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions.</title>
            <authorList>
                <person name="Wang P."/>
                <person name="Li J."/>
                <person name="Weaver C."/>
                <person name="Lucius A."/>
                <person name="Sha B."/>
            </authorList>
            <dbReference type="PubMed" id="28375147"/>
            <dbReference type="DOI" id="10.1107/s2059798317002662"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 1-164</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716227.2">
        <property type="nucleotide sequence ID" value="XM_711134.2"/>
    </dbReference>
    <dbReference type="PDB" id="5U2L">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.66 A"/>
        <property type="chains" value="A=1-164"/>
    </dbReference>
    <dbReference type="PDBsum" id="5U2L"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTP9"/>
    <dbReference type="SMR" id="A0A1D8PTP9"/>
    <dbReference type="FunCoup" id="A0A1D8PTP9">
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTX6</accession>
    <name>A0A1D8PTX6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="14">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">CAALFM_CR09110CA</name>
        <name evidence="17" type="ordered locus">orf19.7307</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="14"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_711348.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_CR09110CA"/>
    <dbReference type="CGD" id="CAL0000179322">
        <property type="gene designation" value="orf19.7307"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09110C_A"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="CLDPENW"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000178864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="303" mass="34264" checksum="ACB7B7D0CC121D26" modified="2017-01-18" version="1">MSFKTNATIIQFGGILHKLSHDSALTKTPMDVNVFIPPINPTSTTKQKIPVLIYLSGLTCTPQNATEKSFFQYWASKYGFAIVFPDTSPRGAKIEGEDDSWDFGTGAGFYVDATQSPWNKNYQMYSYIHKELLDKLSEQFIELDFENNIGITGHSMGGMGALVGFLTQPKKYKSISAFAPISNPSIVQWGEKNFGNYLGNDDKQNWYKYDPTHLIKQYTTTNDYQPSILIHQGLNDNFYADQLKPENFVKAAKEANYKGEIDLRLVDGYDHSYFFISSFVEDHAKHHAKYLGLTTTTTTTKND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2025-06-18" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>O94048</accession>
    <accession>A0A1D8PIN5</accession>
    <accession>Q59XW5</accession>
    <name>HEM3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Porphobilinogen deaminase</fullName>
            <shortName>PBG</shortName>
            <ecNumber>2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Hydroxymethylbilane synthase</fullName>
            <shortName>HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HEM3</name>
        <name type="ordered locus">CAALFM_C210360CA</name>
        <name type="ORF">Ca38F10.02</name>
        <name type="ORF">CaO19.1742</name>
        <name type="ORF">CaO19.9309</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="1">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text>Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="miscellaneous">
        <text>The porphobilinogen subunits are added to the dipyrromethan group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61"/>
    <dbReference type="EMBL" id="AL033502">
        <property type="protein sequence ID" value="CAA21999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714388.1">
        <property type="nucleotide sequence ID" value="XM_709295.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O94048"/>
    <dbReference type="SMR" id="O94048"/>
    <dbReference type="FunCoup" id="O94048">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="237561.O94048"/>
    <dbReference type="EnsemblFungi" id="C2_10360C_A-T">
        <property type="protein sequence ID" value="C2_10360C_A-T-p1"/>
        <property type="gene ID" value="C2_10360C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643940"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210360CA"/>
    <dbReference type="CGD" id="CAL0000176208">
        <property type="gene designation" value="HEM3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10360C_A"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="InParanoid" id="O94048"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="PRO" id="PR:O94048"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000143038" description="Porphobilinogen deaminase">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="340" mass="37756" checksum="2DDAE0D08804C83D" modified="1999-05-01" version="1">MPHHIMSINDSNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLWTKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYKSLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASAGLIRLGLGHRITSYLDDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAERSLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVGIELGDKLKAKGAKEILDKIDMTRNINARPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KK0</accession>
    <name>Q59KK0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">KCS1</name>
        <name evidence="6" type="ordered locus">CAALFM_CR05260CA</name>
        <name evidence="5" type="ordered locus">orf19.8622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710272.1">
        <property type="nucleotide sequence ID" value="XM_705180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KK0"/>
    <dbReference type="SMR" id="Q59KK0"/>
    <dbReference type="FunCoup" id="Q59KK0">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59KK0"/>
    <dbReference type="GeneID" id="3648120"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05260CA"/>
    <dbReference type="CGD" id="CAL0000185409">
        <property type="gene designation" value="KCS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05260C_A"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042569_4_0_1"/>
    <dbReference type="InParanoid" id="Q59KK0"/>
    <dbReference type="OMA" id="ACMTAKC"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000185409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="352" mass="40528" checksum="E44F906E8AC5F37B" modified="2005-04-26" version="1">MVLIVVDVLRKKNFDTGVVMNNITTSQMQPFKNKVGGHTPIFSISKQEICKELNNTERNFYKKISKNHPLFYYMPRYKGSNGSQIILEDLTSQMRTPCILDLKMGTRQYGCNATITKQQSHRAKARSTTTRKLGVRICGLQIFNYQNKYFYQDKYLGRKITVGKQFGKILAKFLYNGHDIYSLLNRIPHLIDQLKELYTIFTGLPGYRMYGSSILLMYEGGEDNSENQVKVKIIDFANAVIAGEENIDNVTVPPQHPDSPDLGYLRGLNSLIVYFTLIFSILSRIKLNNTKEMVDWIQENKQTLKEQSCPWLDDYAELDGLKDGSIHQDMCDDPFDIEYPEYTPEEDEGLSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q59L25</accession>
    <accession>A0A1D8PJ70</accession>
    <accession>Q59L33</accession>
    <name>AIM24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM24</name>
        <name type="ordered locus">CAALFM_C301170WA</name>
        <name type="ORF">CaO19.10664</name>
        <name type="ORF">CaO19.3154</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710437.2">
        <property type="nucleotide sequence ID" value="XM_705345.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59L25"/>
    <dbReference type="FunCoup" id="Q59L25">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_01170W_A-T">
        <property type="protein sequence ID" value="C3_01170W_A-T-p1"/>
        <property type="gene ID" value="C3_01170W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647958"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301170WA"/>
    <dbReference type="CGD" id="CAL0000185321">
        <property type="gene designation" value="orf19.10664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01170W_A"/>
    <dbReference type="eggNOG" id="ENOG502RXC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040665_0_0_1"/>
    <dbReference type="InParanoid" id="Q59L25"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="PRO" id="PR:Q59L25"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.160.10:FF:000004">
        <property type="entry name" value="Altered inheritance of mitochondria protein 24, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399571" description="Altered inheritance of mitochondria protein 24, mitochondrial">
        <location>
            <begin position="31"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="484" mass="53346" checksum="BDDD4EB63A28B532" modified="2017-03-15" version="2" precursor="true">MSLNQYIRPVRTKLSHISCIRNISITQSSINTTIKNDESISKTTTIPENIQQAKELAGYRALEIPEFKTLGSAEGTTATATGSSSSSSSSILSINVPPSVPVYIRRGSLLSIYGIQEISSIDSVRSQLQFPNFWKRLIYGGYVSGYQKLISTTPFSLLISSKSRSSGSGGGSGSGSGFEKSFVNLVLDGTTDWAILDKSALQVYTGNSLSITMHKLPKFISKKLSRSLKKDKKSKTNTNKLETGLFSWKKLGYTLLSGRGKVGLVGNGSSSGYGSSIYNINLNQNEEILINKNNLLGITVNGPYDLQNCIVKYEFPIINNANPTNTNINIKEPVTIVKPKLIQPTTWNLIVLKLKNFNNGFKKFFQIINKYTLGLKTTSYNYLAGNQDFIKVIGPRNLLLQSNTNKSHRGFNNIIPRNKPQAKVWPTNQTTTKVDESSSFSTPKDYLNHVTIEPGKGAVFKSTLDFSETVESIENKNKNKNKSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MG1</accession>
    <accession>A0A1D8PHJ2</accession>
    <accession>Q59MG0</accession>
    <name>DPH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="2">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPH1</name>
        <name type="ordered locus">CAALFM_C205840WA</name>
        <name type="ORF">CaO19.12674/12675</name>
        <name type="ORF">CaO19.5207/5208</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710915.2">
        <property type="nucleotide sequence ID" value="XM_705823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MG1"/>
    <dbReference type="SMR" id="Q59MG1"/>
    <dbReference type="FunCoup" id="Q59MG1">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MG1"/>
    <dbReference type="EnsemblFungi" id="C2_05840W_A-T">
        <property type="protein sequence ID" value="C2_05840W_A-T-p1"/>
        <property type="gene ID" value="C2_05840W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647484"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205840WA"/>
    <dbReference type="CGD" id="CAL0000187558">
        <property type="gene designation" value="orf19.12674"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05840W_A"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112098_0_0_1"/>
    <dbReference type="InParanoid" id="Q59MG1"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="PRO" id="PR:Q59MG1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000083369" description="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O58832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="426" mass="48532" checksum="CB83F0C71E371E3E" modified="2017-03-15" version="3">MSPVEKPVEVEKPKVPKRRFVGKKPQNITIKDGEQPLTKTINPARHIGRVMNQIPDDILNDKELNEAIKLLPSNYNFEIHKTIWNIRKTNCKRVALQMPEGLLIYSLIISDILEQFCQVETIVMGDVSYGACCIDDYTARSLDCDFIVHYAHSCLVPIDITSIKVLYVFVTINIDETHLINTIKLNFERGTQIAIFGTIQFNPTIHSVKAKLENDTEKPMYLIPPQTRPLSKGEVLGCTSARLDKEHIKAMIYIGDGRFHLESSMIHNPEIPAYRYDPYSRKFTREYYDHKQMIDVRKDAISTTKYATKVGLILGALGRQGNPITLDKLEKSLSEKGIQVVKIILSEILPQKLAMFDDVDAFVQVACPRLSIDWGYAFNKPLLTPYEAMVMLEKDTMGDEKVYPMDYYSKDGYGRGSIPDHSHLTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PW0</accession>
    <accession>A0A1D8PE52</accession>
    <name>PIR32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell wall mannoprotein PIR32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PIR32</name>
        <name type="synonym">PIR3</name>
        <name type="ordered locus">CAALFM_C107620CA</name>
        <name type="ORF">CaO19.10299</name>
        <name type="ORF">CaO19.2783</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Mol. Cell. Proteomics" volume="6" first="460" last="478">
            <title>Integrated proteomics and genomics strategies bring new insight into Candida albicans response upon macrophage interaction.</title>
            <authorList>
                <person name="Fernandez-Arenas E."/>
                <person name="Cabezon V."/>
                <person name="Bermejo C."/>
                <person name="Arroyo J."/>
                <person name="Nombela C."/>
                <person name="Diez-Orejas R."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="17164403"/>
            <dbReference type="DOI" id="10.1074/mcp.M600210-MCP200"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Mycopathologia" volume="174" first="107" last="119">
            <title>Deletion of the Candida albicans PIR32 results in increased virulence, stress response, and upregulation of cell wall chitin deposition.</title>
            <authorList>
                <person name="Bahnan W."/>
                <person name="Koussa J."/>
                <person name="Younes S."/>
                <person name="Abi Rizk M."/>
                <person name="Khalil B."/>
                <person name="El Sitt S."/>
                <person name="Hanna S."/>
                <person name="El-Sibai M."/>
                <person name="Khalaf R.A."/>
            </authorList>
            <dbReference type="PubMed" id="22391823"/>
            <dbReference type="DOI" id="10.1007/s11046-012-9533-z"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable structural component of the cell wall involved in cell wall integrity and virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is induced by host macrophages.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">O-glycosylated. Extensively O-mannosylated.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Leads to increased chitin content in the cell wall, hyperfilamentation, and resistance to sodium dodecyl sulfate, hydrogen peroxide, and sodium chloride. Also shows an increased virulence in a mouse model.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711725.2">
        <property type="nucleotide sequence ID" value="XM_706633.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PW0"/>
    <dbReference type="STRING" id="237561.Q59PW0"/>
    <dbReference type="GlyCosmos" id="Q59PW0">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_07620C_A-T">
        <property type="protein sequence ID" value="C1_07620C_A-T-p1"/>
        <property type="gene ID" value="C1_07620C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646670"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107620CA"/>
    <dbReference type="CGD" id="CAL0000195669">
        <property type="gene designation" value="PIR32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07620C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_689094_0_0_1"/>
    <dbReference type="InParanoid" id="Q59PW0"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="PHI-base" id="PHI:2597"/>
    <dbReference type="PRO" id="PR:Q59PW0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000428630" description="Probable cell wall mannoprotein PIR32">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17164403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22391823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="422" mass="48491" checksum="63AB5988856481DC" modified="2017-03-15" version="2" precursor="true">MIHYLIFPILLIFFQIIKSSGYYVPANGDDWTILKPPSCKNKLPGQYIDSLPFTFGIVVNPYILNEDGDYEKPIVSKIKPSLTTTTFVTSIITTSTATAPGSKPTKTKDIIVQIHDGQVQKMKHKHDYSSGGGDDDDDDEDCFDEKNIDMAAKRDYQDMNTQEQANEDSGQVLAESDSHQQVVDQNQQINEEEEETQEQQMQEENNNTNEIEDNKVQEFETIEEIYDDIDNNESRPNNSKKYHKKRPHNNYENKHGHKDYHEDHHHNHRYKDHENGHEEDDHKWNKPKPMPEQEEQEQEQEQKPKHEKSEGYESEFVSPVYSVACYTNSTLKMTLTDGILRDSDDRIGCIVSGHQFQFDGPTPQHGAIYAAGWSVTKQGQLALGDSTKFYQCASGDFYNLYDEPIAFQCHPVTLDVVELIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PZ2</accession>
    <name>Q59PZ2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SPC97</name>
        <name evidence="9" type="ordered locus">CAALFM_CR06740WA</name>
        <name evidence="8" type="ordered locus">orf19.8327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="5705" last="5705">
            <title>The cryo-EM structure of a gamma-TuSC elucidates architecture and regulation of minimal microtubule nucleation systems.</title>
            <authorList>
                <person name="Zupa E."/>
                <person name="Zheng A."/>
                <person name="Neuner A."/>
                <person name="Wurtz M."/>
                <person name="Liu P."/>
                <person name="Bohler A."/>
                <person name="Schiebel E."/>
                <person name="Pfeffer S."/>
            </authorList>
            <dbReference type="PubMed" id="33177498"/>
            <dbReference type="DOI" id="10.1038/s41467-020-19456-8"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13" key="5">
        <citation type="journal article" date="2025" name="Nat. Commun." volume="16" first="402" last="402">
            <title>Structural insights into the interplay between microtubule polymerases, gamma-tubulin complexes and their receptors.</title>
            <authorList>
                <person name="Zheng A."/>
                <person name="Vermeulen B.J.A."/>
                <person name="Wurtz M."/>
                <person name="Neuner A."/>
                <person name="Lubbehusen N."/>
                <person name="Mayer M.P."/>
                <person name="Schiebel E."/>
                <person name="Pfeffer S."/>
            </authorList>
            <dbReference type="PubMed" id="39757296"/>
            <dbReference type="DOI" id="10.1038/s41467-024-55778-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711781.1">
        <property type="nucleotide sequence ID" value="XM_706689.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ANZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="C=1-871"/>
    </dbReference>
    <dbReference type="PDB" id="9H9Q">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="C/J=1-871"/>
    </dbReference>
    <dbReference type="PDB" id="9H9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="8.20 A"/>
        <property type="chains" value="C/I/O/U/a/g/m=1-871"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PZ2"/>
    <dbReference type="EMDB" id="EMD-11835"/>
    <dbReference type="EMDB" id="EMD-51971"/>
    <dbReference type="EMDB" id="EMD-51972"/>
    <dbReference type="SMR" id="Q59PZ2"/>
    <dbReference type="FunCoup" id="Q59PZ2">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PZ2"/>
    <dbReference type="GeneID" id="3646616"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06740WA"/>
    <dbReference type="CGD" id="CAL0000201571">
        <property type="gene designation" value="SPC97"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06740W_A"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007738_2_0_1"/>
    <dbReference type="InParanoid" id="Q59PZ2"/>
    <dbReference type="OMA" id="QNMSGDP"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="446"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000201571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7ANZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="9H9Q"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9H9R"/>
        </source>
    </evidence>
    <sequence length="871" mass="101545" checksum="BE244299180ED3B0" modified="2005-04-26" version="1">MNTFSSPPNVIREYNDSTYQSPLNSQFHQSPFLQTQSPDYVSLREEEDDNNDKNLDIMSSCIVDSVIYKSQKIAGPLLSQISNLNIQQALIIRELLFTLLGHEGHYIQYSKRYDPTSQISRIEGPDYKIAKNLDISLKVITKKLVKFGKFYSGLKSFIQVFDNNKFGKIVQKFCSEVRKFLSSYQQVLINVEHEFKFNKNFNLNMLDSLLHQEISNEMTHLYQIGIEISRITEERQKMSQAEIMGNFEPTTLANTSMNGINSEPNLYYGKFDCCKGGLLLQVIQERMVYYKGDPTSLDFLTQLFDIVSSDYIGMLNQWLLEGVINDPFDEFMIREKRVPDSFMEIFQSKSEYYWNELFLIKIDGLLNQFQNSTIQSKILNTGKYLNIFKRCTGLHNFESLKEKLTTITSLAAPDLELKIDEFYHRANKMLMKLLFDGYNFPSVVNIFQRLFLFADSFQIDNFIDSTFSELKRGKLKISVSRLQKQYDDIFKEKIENKVGVRPSVYDVLKKNQKLSVTSESLYKVVEELMEKNSDYLISDNNLRGIFHRVASLRDDSRLTISSTADSATENVKDEPTITSVDLTIPLPFPLNLVLNQQLSYQYEIMFKLLINIKFISKYNSSNWQEMNYSKIWTNSHFNSSVKKWILRCRVLHSRICSFIHELENYIVHDVIEHNFEEIKNLIHTTATNLATSELGSDINDEGDNIFNGSLIRGTFNNNSIFDSKVHKHRTTTYVEGISTVEQLIQKFLDYSSTLLNDSLLTREESLRQLRKMLDFIFHFNNYIVQVKKVLVLLNHELFNEYSKEFPTKFEKPMDQESIDKRFANLSDTFLMQYEKFGENLVTFLATIKQVGERENQGLLELSNRLELCFPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QC2</accession>
    <accession>A0A1D8PEC4</accession>
    <name>EAF6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EAF6</name>
        <name type="ordered locus">CAALFM_C108510WA</name>
        <name type="ORF">CaO19.396</name>
        <name type="ORF">CaO19.8026</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711884.1">
        <property type="nucleotide sequence ID" value="XM_706791.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QC2"/>
    <dbReference type="SMR" id="Q59QC2"/>
    <dbReference type="STRING" id="237561.Q59QC2"/>
    <dbReference type="EnsemblFungi" id="C1_08510W_A-T">
        <property type="protein sequence ID" value="C1_08510W_A-T-p1"/>
        <property type="gene ID" value="C1_08510W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646494"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108510WA"/>
    <dbReference type="CGD" id="CAL0000192577">
        <property type="gene designation" value="EAF6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08510W_A"/>
    <dbReference type="eggNOG" id="ENOG502SEZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093901_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QC2"/>
    <dbReference type="OMA" id="GPMEQNR"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="PRO" id="PR:Q59QC2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000086894" description="Chromatin modification-related protein EAF6">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="211" mass="23209" checksum="B19719F39D03C0DC" modified="2005-04-26" version="1">MSTKDTNDVKPTSSKSNEISSSGTATPKKTSSVPAKEDRKDTTKKDIANERTSSSKSKDDSEKYVELKNKLIQQILKKQELTRKLTTLEDSIYQKEIDYFEESPLGNIVKGFENFSKTSGGGGANKRKIVYSEDDHIFSLSSVNYIKSLMKRQGHTSNGGSSKDDFDDYEDSVDPTTASAGSKANSIEKNETPSGSSGTPSRKRKARVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QH4</accession>
    <name>Q59QH4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">KTR4</name>
        <name evidence="9" type="ordered locus">CAALFM_C104000CA</name>
        <name evidence="8" type="ordered locus">orf19.11955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711969.1">
        <property type="nucleotide sequence ID" value="XM_706876.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QH4"/>
    <dbReference type="SMR" id="Q59QH4"/>
    <dbReference type="FunCoup" id="Q59QH4">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="GeneID" id="3646425"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104000CA"/>
    <dbReference type="CGD" id="CAL0000179131">
        <property type="gene designation" value="KTR4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04000C_A"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_1_1_1"/>
    <dbReference type="InParanoid" id="Q59QH4"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000031">
        <property type="term" value="F:mannosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000179131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="480" mass="56713" checksum="FB6EE5D9D0297446" modified="2005-04-26" version="1">MISFISLRRRKLISILAIFTIFILSGSIIGYYNGHHHIIKMVENYTPDDFQNSITALTNKFDFSYLPGFKGIITKNNSTSFESLDDLDINGFSLIPGNVQFKFLNKGNKKGTPEQILEQNMKDYKELLGSKTIGQPKDAKLVPPPPPEELPNYKRANATILSLVRNGELGAIGSSIKRLQKKFNSKYNYPYTFLNDEPFTDRFKQRILKYTGNAPVEFVQIKPEYWQKPSFIDTVKEAKEMEIMFKHDVAYAKKQSYHNMCRFYSSQFYKIPELQKYKYYWRVEPKVNFFTDINYDVFKYMEDTQKIYGFTINLYDNEETVKTLWPETIKYLNQGDNYKYINPKGSFQWLLEDLQNPKKTKFAGGYSTCHFWSNFEIGDFDFFRNEAYDNWVKYLDSTGKFYYERWGDAPVHSIGVSLFADKDKIHFFKDIGYDHDPYTNCPNTETTQMCEIGKFSRWEHLYDQNCLMNWLHHDQPKDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SC5</accession>
    <name>Q59SC5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud20p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">BUD20</name>
        <name evidence="2" type="ordered locus">CAALFM_C208880WA</name>
        <name evidence="1" type="ordered locus">orf19.7850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712602.1">
        <property type="nucleotide sequence ID" value="XM_707509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SC5"/>
    <dbReference type="GeneID" id="3645800"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208880WA"/>
    <dbReference type="CGD" id="CAL0000178577">
        <property type="gene designation" value="BUD20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08880W_A"/>
    <dbReference type="HOGENOM" id="CLU_171224_0_0_1"/>
    <dbReference type="InParanoid" id="Q59SC5"/>
    <dbReference type="OMA" id="VSAKWLI"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000178577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW27876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="113" mass="12594" checksum="3F66FF08E1802F6E" modified="2005-04-26" version="1">MELLFTSSYFRQVIVNNLILDGFTLYYQIDIQNLDAHRKGSAAAATRATGQKHLKPEKAYTKLASSVMLIYCTATITQSTRVSAKWLICMLYGTNQITCTVVSCLCSYLLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SS6</accession>
    <name>Q59SS6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ordered locus">CAALFM_C303740WA</name>
        <name evidence="2" type="ordered locus">orf19.14205</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712744.1">
        <property type="nucleotide sequence ID" value="XM_707651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SS6"/>
    <dbReference type="SMR" id="Q59SS6"/>
    <dbReference type="GeneID" id="3645640"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303740WA"/>
    <dbReference type="CGD" id="CAL0000184435">
        <property type="gene designation" value="orf19.14205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03740W_A"/>
    <dbReference type="eggNOG" id="ENOG502TD76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2183565_0_0_1"/>
    <dbReference type="InParanoid" id="Q59SS6"/>
    <dbReference type="OrthoDB" id="4024724at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000184435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="109" mass="12056" checksum="1CF967B3D9328F10" modified="2005-04-26" version="1">MIANSTNISNRMFRSQRIIILSILAAFLVLLGITSLSGHHQVVVNSVKSMSNKASDSISEFYNKVDSSLSSDEKELIEEGKADAEKLAELADEKSKEIKEEENSNPQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZI8</accession>
    <name>Q59ZI8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial morphogenesis protein SLD7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C204990WA</name>
        <name evidence="12" type="ordered locus">orf19.11015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLD7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714890.1">
        <property type="nucleotide sequence ID" value="XM_709797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZI8"/>
    <dbReference type="SMR" id="Q59ZI8"/>
    <dbReference type="FunCoup" id="Q59ZI8">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZI8"/>
    <dbReference type="GeneID" id="3643445"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204990WA"/>
    <dbReference type="CGD" id="CAL0000201473">
        <property type="gene designation" value="orf19.11015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04990W_A"/>
    <dbReference type="eggNOG" id="ENOG502RZIJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068936_0_0_1"/>
    <dbReference type="InParanoid" id="Q59ZI8"/>
    <dbReference type="OMA" id="DIQLWST"/>
    <dbReference type="OrthoDB" id="4063051at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041564">
        <property type="entry name" value="Sld7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18636">
        <property type="entry name" value="Sld7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sld7 C-terminal" evidence="10">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000201473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW27518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="277" mass="31464" checksum="2FE0C5E25AA18257" modified="2005-04-26" version="1">MNYLTTIQLYESKKNVINDIQLWSTNKTLKLPTITSCKPISYIKYASLPFYLVYCCPIIVYTDDSDTSDYFKTKLVETPLLSNGKSGGVGGGGIGLLCKVDVNTFLVFYYEDNVKMLVLKFSKFIETLPQLDIPSIPKDTLLDLKPSKRIRTNTKIIDKIIEKKKQRSNSFIANPNTTKVNISSGSSILTNQDQINTAINKIIFSGLRIRGLSSNVASSLNDKLTIKEIHQMTFKATQFALRKHNYSFNKRETKKPLRLNDLQDIIENLLQLFVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A337</accession>
    <name>Q5A337_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SKI complex RNA helicase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">SKI2</name>
        <name evidence="13" type="ordered locus">CAALFM_CR08570WA</name>
        <name evidence="12" type="ordered locus">orf19.13783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716263.1">
        <property type="nucleotide sequence ID" value="XM_711170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A337"/>
    <dbReference type="SMR" id="Q5A337"/>
    <dbReference type="FunCoup" id="Q5A337">
        <property type="interactions" value="973"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A337"/>
    <dbReference type="GeneID" id="3642143"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08570WA"/>
    <dbReference type="CGD" id="CAL0000185019">
        <property type="gene designation" value="SKI2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08570W_A"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_1_4_1"/>
    <dbReference type="InParanoid" id="Q5A337"/>
    <dbReference type="OMA" id="DHVNIIM"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
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        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="MTR4-like_stalk"/>
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    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
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    <dbReference type="Pfam" id="PF21408">
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    <dbReference type="Pfam" id="PF21409">
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    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="298"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="569"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="560"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000185019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1245" mass="140909" checksum="8E014EC701805CDD" modified="2005-04-26" version="1">MIIEEVPTNDPLVVDPTTVTTYECPDLNAEERRQNLKTDLLNPSPEINWEILDLVNKPLEINREKIIDKLVINPERLSRTQFRFKRSGIHGHITGYQEEVNLNELENSNTSLSINRGYSSKSESLRGNTSFLPFQPGGLIQQAATEREPKDSGLNLHRNEHGLFDIPPGFVRGLEVGGGGSGSGSLDIEPASSEEEKDSLEGVHISAASEAALNKSTILDGDVSKPKPTVPFDNKEIEGLVPFDYSNFKYTDKKNALDKRTWAHVVDLDHKIEDFQELVPNMARTWPFELDTFQKEAVFHLEQGDSVFVAAHTSAGKTVVAEYAIAMAHRNMTKCIYTSPIKALSNQKFRDFKETFKDIDVGLITGDVQINPEANCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDIDRGVVWEEVIIMLPDHVKYILLSATVPNTFEFANWVGRTKQKDIYVISTPKRPVPLEIFVSAKNQLFKVVDANRRFQENEFRKHKDLLEGGGKKNELPSTTMGSGSRGGPGGTARGGNRGGRGGRGGQGRGGNANRGNFSGPKRFGRDGPKKNTWIDLVNYMKSNNLLPAVVFVFSKKRCEEYADSLRSVDFNNAREKSEIHMFIDRAVGRLKKEDRELPQILKIREMLGRGIAVHHGGLLPIVKECIEILFAKSLVKVLFATETFAMGLNLPTRTVIFSSMRKHDGRSFRNLLPGEFTQMSGRAGRRGLDKTGTVIVMAYDDPLSPTDFKEVVLGTPTKLSSQFRLTYSMILNLLRIEALKVEEMIKHSFSENSTQVLLPENQKRYDEIKKQLQSSTITPCSKCSLEGTEETCNLLTEYENLYGECVVDIHKSPVLKSQLLRVGRLVCFRDVNHNGARMGFVVKSDSANNAIVLLTFDHGKDYEEAIEKYKLPYIPIRDYITKNFPKIKFSGRLRVVLVPYENICFIGRYSLKTSVNSIINNEKSAVQEASEQIQILTKYQNSFEELAFKFTRQLSLHDLTVEKDQLLEKLKSSKAYVCPNFRQHYVEYLDRYLLSQEVEKLERLISDENLELLPDYEQRLQVLEAMGYIDEQHNVVLKGRVACEVNSGWELIITELVLNNFLGDFEPAEIVALLSCFVYEGRTQEEEPPLITPRLEKGKAKILEIAEKLLKVYVEKQVSLTSEEEDFVESKRFALANVVYEWANGLSFNEIMQISVEAEGTIVRVITRLDEICREVKNAALIIGDSTLHLKMVEAQEKIKRDIVFCASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A385</accession>
    <name>Q5A385_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR08190WA</name>
        <name evidence="2" type="ordered locus">orf19.13736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716219.1">
        <property type="nucleotide sequence ID" value="XM_711126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A385"/>
    <dbReference type="STRING" id="237561.Q5A385"/>
    <dbReference type="GeneID" id="3642084"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08190WA"/>
    <dbReference type="CGD" id="CAL0000196914">
        <property type="gene designation" value="orf19.13736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08190W_A"/>
    <dbReference type="eggNOG" id="ENOG502T02G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1722109_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A385"/>
    <dbReference type="OMA" id="FLPWAWI"/>
    <dbReference type="OrthoDB" id="4092725at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000196914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="152" mass="17232" checksum="DEA9A97CD2F09D09" modified="2005-04-26" version="1">MVYSKSLILPMLISIFLPWAWIGFQNTRSSDIGPTKSIPVSINFEKDSEYFNFPDLVAATQIQIDSELRYITNSSVNVQLVDNLNNPKNHTKYSVDLVLSRDNSLGISSDGLKGYVLYSYEAIHSNDLPYLIVQTILYHLLKFEIPIEGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A397</accession>
    <name>Q5A397_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hsp70 chaperone Ssb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">SSB1</name>
        <name evidence="10" type="ordered locus">CAALFM_CR08090WA</name>
        <name evidence="9" type="ordered locus">orf19.13724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716208.1">
        <property type="nucleotide sequence ID" value="XM_711115.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A397"/>
    <dbReference type="SMR" id="Q5A397"/>
    <dbReference type="FunCoup" id="Q5A397">
        <property type="interactions" value="1802"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A397"/>
    <dbReference type="GeneID" id="3642095"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08090WA"/>
    <dbReference type="CGD" id="CAL0000194973">
        <property type="gene designation" value="SSB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08090W_A"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="Q5A397"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd24093">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000194973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="613" mass="66449" checksum="88F84747EA524C4C" modified="2005-04-26" version="1">MADGVFQGAIGIDLGTTYSCVATYDSAVEIIANEQGNRVTPSFVAFTSEERLIGDAAKNQAALNPKNTVFDAKRLIGRAFDDESVQKDIKSWPFKVVESNGQPLIEVEYLDETKTFSPQEISSMVLTKMKEIAEAKIGKKVEKAVVTVPAYFNDAQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLGAGKSEKERHVLIFDLGGGTFDVSLLNITGGVFTVKATAGDTHLGGQDFDTNLLEHFKKEFQKKTGNDISGDARALRRLRTACERAKRSLSSGTQTTVEIDSLFDGEDFSANITRARFEDINSALFKSTLEPVEQVLKDAKISKSQVDEVVLVGGSTRIPKVQKLLSDFFDGKQLEKSINPDEAVAYGAAVQGAILTGQSTNDDTKDLLLLDVIPLSLGVAMQGNVFAPVVPRNTTVPTIKRRTFTTVADHQTTVQFPVYQGERVNCTENTLLGEFDLKNIPPMQAGEPVLEAIFEVDANGILKVTAVEKSTGRSANITISNSIGRLSTEEIEKMISDAEKFKSSDDAFAKRHEQKQKLEAYVASVESTVTDPVLSAKLKKSAKDKIEAALSDALQTLEIEESSADDYRKAELALKRAVTKGMATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3N5</accession>
    <name>Q5A3N5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C112280CA</name>
        <name evidence="7" type="ordered locus">orf19.12699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716304.1">
        <property type="nucleotide sequence ID" value="XM_711211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3N5"/>
    <dbReference type="STRING" id="237561.Q5A3N5"/>
    <dbReference type="GeneID" id="3642019"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112280CA"/>
    <dbReference type="CGD" id="CAL0000194947">
        <property type="gene designation" value="orf19.12699"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12280C_A"/>
    <dbReference type="eggNOG" id="ENOG502SDRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180597_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A3N5"/>
    <dbReference type="OMA" id="RWTNERN"/>
    <dbReference type="OrthoDB" id="3980895at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000194947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="232" mass="27739" checksum="C1D81C3235695610" modified="2005-04-26" version="1">MLRSQIIQTRSFTSLTRNLSWFGDIFGKNKTSIESKQKRQDIITKQDELTESDSIKIHHLTFKNSDKYQSFTIEQNMPNFHKLKNWKFQKSLTPNDYESFYSDKSILQNIINQELKNLIQKDIIVSRDNYKDIKLDDLSFRFQIVKSLQSKLGIDINDYIISKSHDLETLYEEIENLVNKRWKFERNPNAIVLRSEDFDAENIYLNQERNDFEKNLELQKLTQKLKISQSQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-04-09" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4K7</accession>
    <accession>A0A1D8PPN7</accession>
    <name>TRY5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator of yeast form adherence 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TRY5</name>
        <name type="ordered locus">CAALFM_C601500CA</name>
        <name type="ORF">CaO19.10938</name>
        <name type="ORF">CaO19.3434</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Transcription factor required for yeast cell adherence to silicone substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Decreases cell adherence to silicone substrate.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716741.2">
        <property type="nucleotide sequence ID" value="XM_711648.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4K7"/>
    <dbReference type="SMR" id="Q5A4K7"/>
    <dbReference type="STRING" id="237561.Q5A4K7"/>
    <dbReference type="EnsemblFungi" id="C6_01500C_A-T">
        <property type="protein sequence ID" value="C6_01500C_A-T-p1"/>
        <property type="gene ID" value="C6_01500C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641619"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601500CA"/>
    <dbReference type="CGD" id="CAL0000180184">
        <property type="gene designation" value="TRY5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01500C_A"/>
    <dbReference type="HOGENOM" id="CLU_007678_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A4K7"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="PRO" id="PR:Q5A4K7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF34">
        <property type="entry name" value="ZINC FINGER PROTEIN YGR067C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000426066" description="Transcriptional regulator of yeast form adherence 5">
        <location>
            <begin position="1"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="129"/>
        </location>
    </feature>
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            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="988" mass="115741" checksum="C083CEB7EB62CABF" modified="2017-03-15" version="2">MAAQKKYICAFCARAFTRSEHKQRHERSHTNEKPFHCLHCTSSFVRRDLLQRHCRTVHHTNLNPSTLPSNKSLKNPTTNPLDLSNNEGTTTTTKTGNRKNNSNKNGAKNDKSTNPNPAVSNDDNRSSVGDITTQLPFQVQFNTQLPYQQQQQQQQQQQYPILQNQGIPMKQSFSMESDQHSLTTFDSPTSSLGVSMTPSGSTNSEIVLQQQQQTTKRRKRSQENNSNNNTKLIAKELNHDLVHLLSITKKLTTLLQHYDNVKVNITDSFLIGYVHIQQQAKNFTIFEKILKDLVYYLNTYHINNLQQQNQFPPSQQQNHYTINHFKIGISYCVIALGFLIDHKPNRAIQFFKKSWNLLIKTLIPQYNSNNNLLDQIEILYNLFLLCYIYLQFNLETFDINEKQHEHHSYEQGDEHEDHHQEQVYINNQVILNYLNDISFIIASNLKDVATNNLIDHNLNLFWNIYILLSSYITKEPPKIHQILLNKNLKQNDTLVSLMQKFSKSFINMDMDDEQLKLVVVAALNNELKLYFNDTVDEFEPENSKNKRKFIYDNRNVLHNAIILINKSINFYNPSASLVNDAKMFELKLFELFKKNLIINSPMKYHELFNNYIFIPQHYYHWQLLTLTLKEINQNNVIFNQIHSILTTTTGSNVCFSFIDFENLLKNSFLNYKANPIVINNNLLIISYPIIILSNYLNLDNLMTSMGQMNQLQFINLNIFIIEWYLIMMKVLIIIWDDTLIDFEDNYILQTLMYILLDNKSCLLKRLNIDTSKLEYDVNCERLSFNQKWFWIIKLKFDSIFENWMNFLKNKNNNVTNNSNVTNTSTTGITNTNHNHNDSYLHHFNVNVSNFKFNLNKYLNEYFVTGDFKFREQLDQNDPDQFQGSMSMDEEPDFTTAMQTSQTINSFMPIHNHNSRNQVYQQHNQDTPMTSRRDSTNINENNIAQTSSFISNSNYQGSNSNNMINYNEFQDRNYKRSSSITLGILAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5P1</accession>
    <name>Q5A5P1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ORC2</name>
        <name evidence="10" type="ordered locus">CAALFM_C210760CA</name>
        <name evidence="9" type="ordered locus">orf19.12818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717161.1">
        <property type="nucleotide sequence ID" value="XM_712068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5P1"/>
    <dbReference type="SMR" id="Q5A5P1"/>
    <dbReference type="FunCoup" id="Q5A5P1">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A5P1"/>
    <dbReference type="GeneID" id="3641238"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210760CA"/>
    <dbReference type="CGD" id="CAL0000181235">
        <property type="gene designation" value="ORC2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10760C_A"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382621_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A5P1"/>
    <dbReference type="OMA" id="YVEHKMC"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="366"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="616"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A646</accession>
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        <submittedName>
            <fullName evidence="2">Mrp8p</fullName>
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        <name evidence="1 2" type="primary">MRP8</name>
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        <name evidence="1" type="ordered locus">orf19.11325</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="205" mass="23398" checksum="A2E3D8FBAD6609AA" modified="2005-04-26" version="1">MSELSKLNEAKAKVAELEALVKKQASVMVQARQKLVDVELRNKKNQAAQNINQQPALDLTDYVNNDDIVQLVTELQTQLDALEARTMRRTYNATVQGDDEKLAPITNKDGDLPDFALPVTLKEFKSLEKIDLIRLGVFYEIILPDGEEIDHALQQTNSKEAILDINKKKDIIELSKNFDEDQANEIYDELARYFGIKHRRNSDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A768</accession>
    <name>Q5A768_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bul1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">BUL1</name>
        <name evidence="5" type="ordered locus">CAALFM_C108170CA</name>
        <name evidence="4" type="ordered locus">orf19.12560</name>
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    <organism evidence="5 6">
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717631.1">
        <property type="nucleotide sequence ID" value="XM_712538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A768"/>
    <dbReference type="SMR" id="Q5A768"/>
    <dbReference type="STRING" id="237561.Q5A768"/>
    <dbReference type="GeneID" id="3640734"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108170CA"/>
    <dbReference type="CGD" id="CAL0000184571">
        <property type="gene designation" value="BUL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08170C_A"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022027_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A768"/>
    <dbReference type="OrthoDB" id="4007955at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
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        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="526"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000184571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="741" mass="84755" checksum="FF0403188FFBC5C0" modified="2005-04-26" version="1">MNNTKNSENHTSSVDDTIGTILPSYSMFTSTIGMNVNVPEDNYQRYTDAEPPSYNQEDLNTVESSSVSVSQASSALHNMSLGSSRTSTNDSLQVIDENGSFIVADENTWHWRETILDNVHRLPNLTFQSHKISEAVKLEVHFTKDVCELGKKPELIDPYIYEYKQGDLLNGYILIKNTSEKPIPFEMFYLLFEGNFMVANPLDAKDKVPVKIRKFLEMFDFSGSWNEGNISRLATEEMNPHACLNIIDPIDGSALCFKKEKIIFPGITYKRFFTFRIPNNLLDSECNDHALSKHVELPPTMGLSRWETAHFPERAINKIKDFTLLNTSVSYGVMARFIGRKSTWEVDFGKIDTPSNSTRIVNSQGDEYIILKELTNYFRVVKKTPIPTDNERLMKLLENKLMYNNFISRIKEKIDAGKRLIESIESSNFTGSIDIGKELTQTELELAKCKQFYKPDSIRDTKLNPNRIEHYETFLPLVRKSLTGNKPLGTLRVSTPKKEFCVSYIPPLRFRQQSIENLVSSWKFEIPVDMSIAYSSLNTKPSQLPNIVDVKAELAVLTIRSDSKPIPIEFNHDLIFNKQCNGQFIDSDNFNENIIKPFRKYSTDLYKIYKKLGSENFKIEQSLVDDLKSICKLEHKTFNLRVKDIMIDGKPGKPSSKGVTQWSIDENGAKSSFTVGINLENLELKGDTNSNKSKKSYDNFTLVPDFQSCFMCRLYHVKLTMALSNDRYVNIKVPVRVQKVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8I8</accession>
    <accession>A0A1D8PQA4</accession>
    <name>IHD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Induced during hyphae development protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>GPI-anchored protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IHD1</name>
        <name type="synonym">PGA36</name>
        <name type="ordered locus">CAALFM_C603850CA</name>
        <name type="ORF">CaO19.13183</name>
        <name type="ORF">CaO19.5760</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
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        <scope>GENOME REANNOTATION</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference key="3">
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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        <scope>INDUCTION</scope>
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        <scope>INDUCTION</scope>
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        <scope>INDUCTION</scope>
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    <reference key="7">
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        <scope>INDUCTION</scope>
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        <scope>INDUCTION</scope>
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    <reference key="11">
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                <person name="Cao F."/>
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            <dbReference type="DOI" id="10.1091/mbc.E05-06-0502"/>
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    <reference key="12">
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        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
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    <reference key="13">
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            <dbReference type="DOI" id="10.1371/journal.pone.0058613"/>
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    <reference key="14">
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            <title>Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo.</title>
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                <person name="Carlisle P.L."/>
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        <text evidence="14">GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.</text>
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    <comment type="induction">
        <text evidence="3 4 5 6 7 8 9 10 12 13 14">Induced during yeast to hyphae transition, during biofilm formation, during oralpharyngeal candidasis, and in response to serum. Regulated BY FLO8, NRG1, RFG1, RGT1, TUP1, TSA1, and UME6.</text>
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        <text>The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
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                <person name="Magee B.B."/>
                <person name="Newport G."/>
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                <person name="Scherer S."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718087.1">
        <property type="nucleotide sequence ID" value="XM_712994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8J7"/>
    <dbReference type="SMR" id="Q5A8J7"/>
    <dbReference type="FunCoup" id="Q5A8J7">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A8J7"/>
    <dbReference type="GeneID" id="3640307"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603770CA"/>
    <dbReference type="CGD" id="CAL0000201445">
        <property type="gene designation" value="ORM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03770C_A"/>
    <dbReference type="eggNOG" id="KOG3319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072117_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A8J7"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090156">
        <property type="term" value="P:intracellular sphingolipid homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000201445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="268" mass="29661" checksum="54A49FFE003449D6" modified="2005-04-26" version="1">MTDVSPNSKIEHLTPDNITVTAPSEPPFSSSSSTSASASTPTPIAEEKLSTPIPTPSPSHRRGSSIGSSTSPSSSTRNRSNSNSANALTPTPSHHQPAHSITRQRRSSSLIQHLEPDTLDTKIDQALNPNVNANWVHQKGAWVIHVVIIILVKMIFNFISVLNNDWKWTLTNLTYNIGSYIMFHQVKGTPFEFNSGAYDNLTMWEQIDNGDQYTPSKKFLMLVPIGLFLISTHYSSYNLNLFILNGLSCLCVVVPKLAFAHRLRVTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADN4</accession>
    <name>Q5ADN4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">CAALFM_C306940WA</name>
        <name evidence="16" type="ordered locus">orf19.14099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719902.1">
        <property type="nucleotide sequence ID" value="XM_714809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADN4"/>
    <dbReference type="SMR" id="Q5ADN4"/>
    <dbReference type="STRING" id="237561.Q5ADN4"/>
    <dbReference type="GeneID" id="3638509"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306940WA"/>
    <dbReference type="CGD" id="CAL0000199793">
        <property type="gene designation" value="orf19.14099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06940W_A"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009798_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ADN4"/>
    <dbReference type="OMA" id="WEWITID"/>
    <dbReference type="OrthoDB" id="4096693at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="306"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000199793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW28698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="609" mass="69353" checksum="762A4C7EF635BE0D" modified="2005-04-26" version="1">MSVIADLPSLYAFDENKPVLVFTDASQLAIGAIITQEHLIQGQKSLVPVAMVSLRLSATQQRYSTLERELLTIVYVLQKYKQFMSREVQFYTDHQAITTIGSAKSEPANRIKRFIDIIQSFNPSIYFIPGQFNFIADFLSRYNLDKIPHELNEEAILNQTSSIYLPTLRTTEPIPLAPIQPVQRHHIHIDNLTDNQLQQIHDQLCGSYENNNSNELLPTDQFVILQDQFHVVLSSTQVVPVVTADTLANTATKVHEHHHASIRVTDYLVSKIQWHPNHKLLCTNVIRNCSVCQLSSTFETAHRELYPLTPTKTFSRWGLDFIGPLPMSDNLSCCLNAIEYVSGLIYSWPCSSPNSDVVISMLNLIRQVHSTPVEVITDNGSAFTSNATQSFCATAGISIKYASVYHPMSNGRMELGNKLLKKILKSMTDAYYTKWPQVLANAVMVYNSTPTTFNKTPYYLSIGISTDMSEFTTYLANEFEWKEGQLSQSSLLQDLHNDVQVRLAELDGVNKNVEKHNDLRVRRMAYINSMRQPFQKPASFIKGDWDLLRRRVKRKKSEYNYMGPYQIAKVLDKHAYVICDTNGNMINGTIHHDDLKYCYSFNDNSISRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AG95</accession>
    <name>Q5AG95_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bur2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">BUR2</name>
        <name evidence="5" type="ordered locus">CAALFM_C502670WA</name>
        <name evidence="4" type="ordered locus">orf19.11760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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    <reference evidence="14 15" key="2">
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                <person name="Martchenko M."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <sequence length="374" mass="41300" checksum="CE715335C93AC16A" modified="2005-04-26" version="1">MLRLGLTRSFRATSASLKTVRVGIPSNIATRSPLIYSSIRFNSSTTTSGTEIQDKLTSFDDTTTSAILENVTNLHSDQLGYLQSIGLAQGWGPTSLIERLLEVTHVYTGLPWWGTIVVATIAVRLVLFPLYVRASSNATKMSKIKPQIDELLQQIKTGDTVDQMRAMEKRRLIMKENGVSTLATLFPAVQLPLAYGFFQALRKMANHNVEGFSDQGYAWFQNLIEVDPYLGLQAISAAAIIAVVRVGGETGQHAMAAGMKKVMTVVPIASIFITKGFASAIILYFAVNSIFSLIQSSLFKSSWFRKIAGMPPKLSLAEMQANNPKANQSIKDMVSKFVDDSKEKSIKQARETNKKLEATQRRKDSVNQGFIKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <sequence length="153" mass="17855" checksum="625FB365546FF9F8" modified="2005-04-26" version="1">MSTRMFITSKNKYNKKIENAIKKINKLTANPETSFKFDAERFKEIELFVYGQRPITYKPAWGLKLFWKDNLPTLRYHNPDIQFTVNNITVESESELSKLPLKLKVHGTDQSNSFEINCTDKPPSKILSELIEITKARKLTEEELPKLPLRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH74</accession>
    <accession>Q3MP96</accession>
    <name>Q5AH74_CANAL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="9" type="ordered locus">CAALFM_C702500CA</name>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000200315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="306" mass="35484" checksum="E07E7712EAA1E342" modified="2005-04-26" version="1">MALYDIINYFYGSNSKFNRITWGFKSPTFIKWRITDFILIIVLIVLFFVTSQAEPFHRQFYLNDMTIQHPFAEHERVTNIQLGLYSTVIPLSVIIIVALISTCPPKYKLYNTWVSSIGLLLSVLITSFVTNIVKNWFGRLRPDFLDRCQPANDTPKDKLVSIEVCTTDNLDRLADGFRTTPSGHSSISFAGLFYLTLFLLGQSQANNGKTSSWRTMISFIPWLMACYIALSRTQDYRHHFIDVFVGSCLGLIIAIWQYFRLFPWFGGNQANDSFNNRIMIEEIKRKEEIKQDENNYRRISDISTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AHH6</accession>
    <name>Q5AHH6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type 1 protein phosphatase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">SDS22</name>
        <name evidence="8" type="ordered locus">CAALFM_C204020CA</name>
        <name evidence="7" type="ordered locus">orf19.8440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720944.1">
        <property type="nucleotide sequence ID" value="XM_715851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AHH6"/>
    <dbReference type="SMR" id="Q5AHH6"/>
    <dbReference type="FunCoup" id="Q5AHH6">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AHH6"/>
    <dbReference type="GeneID" id="3637362"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204020CA"/>
    <dbReference type="CGD" id="CAL0000176734">
        <property type="gene designation" value="SDS22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04020C_A"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AHH6"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000176734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="374" mass="43062" checksum="AA31674D01C55413" modified="2005-04-26" version="1">MPIQETNKELVEKPVGILQEEEKEEPILSHTEDEDDDDDDDEDEDDKNQQGNSAVQYPGTVLPDNHPQEIEADQDLTTGYDLDTDYIDLVHLKISSLEDLHLERFKKLESLCLRQNLITSMVGVKDLPDTLEELDLYDNRINHISSSIKHLVHLTNLDLSFNRIKNIKNIETLVELENLYFVQNKIREIKNLDTLTKVTNLELGGNKIEVIENLDKLVNIKQLWLGKNRIYKLQNMDNLVNLRVLSIQSNRITKIEGLENLKNLEELYLSHNGISEIENLENNINLQVLDVTANKISNLKGLSHLVKLTDFWCSYNQVSSFEEIGKELGKLPDLECVYFEGNPVQLQNPSAYRRKMKLYLGPSLNKIDATYVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI84</accession>
    <name>Q5AI84_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">RAD16</name>
        <name evidence="20" type="ordered locus">CAALFM_C102810WA</name>
        <name evidence="19" type="ordered locus">orf19.10486</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721468.1">
        <property type="nucleotide sequence ID" value="XM_716375.2"/>
    </dbReference>
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        <location>
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            <end position="428"/>
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            <begin position="685"/>
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            <begin position="1"/>
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    <sequence length="852" mass="97312" checksum="7C7D6357573CE4AB" modified="2005-04-26" version="1">MAPSRNDVADNESSSDSDTSNIGGGFIIDDISTTRTKRPRRAAARKAANISYAESSDDQESDSIDSDTFANVPAPVKKRKTRTSTRVQSKEKETKKKKTASKRSSSPDDEDDDQEFTLSLDDAKESETTDDDEVEYLGSNQIEKNGSTSAEAIDLADDLDLNNDPDENVPLASRKAPKKRAKGGKRTKKEPKPKMSYYERTTNRLFEHHPSLKEVFPYLKNTPKITPERAEHPPGMTIKLLPFQLEGLNWLIKQEDGEFNGGILADEMGMGKTIQTIGLFMHDRSKGPNLVIGPTVALMQWKNEIEKHTEPGMLKVLLYHGSNRSNSIQELSQYDVILTSYSVLESVYRKQNYGFKRKNGLVKEKSAIHNIEFYRVILDEAHNIKDRNSNTSRAAGKLNTKKRWCLTGTPLQNRIGEMYSLIRYMKLDPFHSYFCTKCDCKSEDWKFSDGRRCDLCQHPPMLHTNFFNHFMLKNIQKFGIAGLGLEGFNNLRSLLDHVMLRRTKIERADDLGLPPRVVEIRRDFFNEEEKDLYQSLYSDSKRKFNDYVAEGVVLNNYANIFTLITRMRQLADHPDLVLKRVGSNAISNEIDGVIMCQLCDDEAEEPIESKCHHRFCRMCIQEYMESFMGASNKLECPVCHIGLSIDLEQPAIEVDEELFTKASIVNRIKSGAHGGEWRSSTKIEALVEELYKLRSDRHTIKSIVFSQFTSMLDLIQWRLKRAGFNTVKLSGSMSPQQRDNTIKHFMENTEVEVFLVSLKAGGVALNLCEASQVFLMDPWWNPSVEWQSMDRVHRIGQKRPIRITRFCIEDSIESKIIELQEKKANMIHATINNDDAAISRLTPDDLQFLFMN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJC1</accession>
    <accession>A0A1D8PJA7</accession>
    <name>BRO1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar protein-sorting protein BRO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>BRO domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">BRO1</name>
        <name type="ordered locus">CAALFM_C301750CA</name>
        <name type="ORF">CaO19.1670</name>
        <name type="ORF">CaO19.9239</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BRO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721747.2">
        <property type="nucleotide sequence ID" value="XM_716654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJC1"/>
    <dbReference type="SMR" id="Q5AJC1"/>
    <dbReference type="FunCoup" id="Q5AJC1">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJC1"/>
    <dbReference type="EnsemblFungi" id="C3_01750C_A-T">
        <property type="protein sequence ID" value="C3_01750C_A-T-p1"/>
        <property type="gene ID" value="C3_01750C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636590"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301750CA"/>
    <dbReference type="CGD" id="CAL0000196077">
        <property type="gene designation" value="BRO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01750C_A"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AJC1"/>
    <dbReference type="OMA" id="YLKRSYG"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="PRO" id="PR:Q5AJC1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071285">
        <property type="term" value="P:cellular response to lithium ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000218861" description="Vacuolar protein-sorting protein BRO1">
        <location>
            <begin position="1"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="606"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="786"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="803"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="899"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="922"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="945" mass="108853" checksum="5BB55AB4F33BC644" modified="2017-05-10" version="2">MKTHLLVVPSKKTEEVNWVKPLNNYLLSIYGNTLQYQDDINSLNKLRQDIRGVNADDTGLKLYYSYYSKLELIDLRIPFHDLNKSKKLQFEWFDSFSSLPYTQNSLAFEKANVLYNIGAILSRFAQFKYNESQQLNGPEGETAFKQSISMLQQSSGIHQFINKNFLHAPSQDLAQSTIKFLSKLMMAQSQEIFTLKVISGDLNQSKNSLIAKLCKSTSVLYEDCYNMINKNKKEGFKITNESYDGNDYEDDLDDDDCDDLEGFLERPEDTEDSDNRYVAAELDSSWISIIYFKYEYYKSLAYYFNGLHLDANRKYGDAIAYLTKSQEVLNGVHSSTLKQVSKGSGDVYELLDNYKYQKDAVTIRLNDLNKDNDLIYHDIVPNLVTLPEIKPMDSTKIIKLGDNAMFHEINEKNYNNFLVNVVPVNIHELSSYYSEEKSQYLRNEIDHFEVSNEEVSSVLEYLKLPKALVSIKESLRGTSSKGNTRNIDELLSQSVIDKVNEISSQYSNDIQRKNTIENSRKEIYQLIKFLTENNCQDDAIQLKKILYDASVSDTKLFALVDETYHQTLGKGIQSTEFKSLFKTVDNKSSNQDSEISLLDIIDDDDDDNTNQDKQIKNIEDYLNDLNNIKQAKFKLIEKLKKEIHNDDISDILVLNMKLKSTNEIKSIIFPEELKKFNPFTNELDKLITNEKSIIEQLKSRWNQLISNPQIKNLQTETNSKNRLIISQSEKIDQFYGNWLKYHNGLIAGEKFYNQLLDQFKNFRNNIDNQLNQGMRSLNIGQQFPTQPMLNRTQSSGLQSNYTGQSSISHSGSLSGQPSGGYNQPQPQQQQLQQQQQQQQQAQFSGAYNQQYSQPHGGYTQFQGYGQGQGQSQTGYQRQPPPPPPQLPPKQSMGSYNFATTLQQQQLPPQQQQQPQQQRTPQNESNLIYDNPSTYNPNMYNFFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJZ5</accession>
    <name>Q5AJZ5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">PRE1</name>
        <name evidence="7" type="ordered locus">CAALFM_C505310WA</name>
        <name evidence="6" type="ordered locus">orf19.11508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721933.1">
        <property type="nucleotide sequence ID" value="XM_716840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJZ5"/>
    <dbReference type="SMR" id="Q5AJZ5"/>
    <dbReference type="FunCoup" id="Q5AJZ5">
        <property type="interactions" value="1109"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJZ5"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="GeneID" id="3636500"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505310WA"/>
    <dbReference type="CGD" id="CAL0000196012">
        <property type="gene designation" value="PRE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05310W_A"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="InParanoid" id="Q5AJZ5"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000196012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="196" mass="22019" checksum="CC85E14AA2B08058" modified="2005-04-26" version="1">MDIILGIKVSDGTLIATSKAATRGISILKDTDDKTRHLNAHNLIAYTGEAGDTVQFAEYVQANIQLYSMRENDIELSPKATASFVRNQLASSLRSRKPYQVNCLIGGYDVKKNEPSLNWIDYLGTQVELPYGAHGYAAFYTTSLLDKHYRKDMTVEDGLKLMDMCVKELQTRMPIDFKGVYIKVVDKDGIRQIESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK09</accession>
    <name>Q5AK09_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C505180WA</name>
        <name evidence="1" type="ordered locus">orf19.11494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721919.1">
        <property type="nucleotide sequence ID" value="XM_716826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK09"/>
    <dbReference type="SMR" id="Q5AK09"/>
    <dbReference type="ESTHER" id="canal-q5ak09">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="3636465"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505180WA"/>
    <dbReference type="CGD" id="CAL0000191996">
        <property type="gene designation" value="orf19.11494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05180W_A"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053543_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AK09"/>
    <dbReference type="OMA" id="YNYSAND"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000191996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45903" checksum="7EA5420B0456A642" modified="2005-04-26" version="1">MISLRALFDLVTLPIKLLLALLKYPIFGGVNKRYKNDLANSLKVILCRSLINFPVKDTPIFATTPTGDMINKGIGKTYPNMTKLPHFGEKFDKQSYWLVESKNRKPNDPVLIYLHGGGYFLDVAPQQIETLLSIYHLLEPAKKSRFSILVLNYNLTSKGFPVPHQLAQLVDTYTSLVRGGSENLLLMGDSAGGNLAITFTQYLRLNKPNLPYPRSVILVSPWVKLIPEVYQNTPGHSYYNYSANDVIQYDRFSSAEVYQGTLGNTKLKSLTVSPGNCPYDPKDWEEIDTYRKPGYSVFVLAGEHESFRDDILEWSKYALDYPIPPNLGNSDGVYNPKIHKYIRNNKDSAHVDVNIEPLGVHDVCFFENLLLSKLENDANLTIDGVDAKQFFAIVNIVKFLDTVLPGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK59</accession>
    <accession>A0A1D8PP16</accession>
    <accession>Q5AKM2</accession>
    <name>HAS1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase HAS1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HAS1</name>
        <name type="ordered locus">CAALFM_C504750CA</name>
        <name type="ORF">CaO19.11444</name>
        <name type="ORF">CaO19.3962</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721871.1">
        <property type="nucleotide sequence ID" value="XM_716778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK59"/>
    <dbReference type="SMR" id="Q5AK59"/>
    <dbReference type="FunCoup" id="Q5AK59">
        <property type="interactions" value="1283"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK59"/>
    <dbReference type="EnsemblFungi" id="C5_04750C_A-T">
        <property type="protein sequence ID" value="C5_04750C_A-T-p1"/>
        <property type="gene ID" value="C5_04750C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636443"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504750CA"/>
    <dbReference type="CGD" id="CAL0000175982">
        <property type="gene designation" value="HAS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04750C_A"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_5_1"/>
    <dbReference type="InParanoid" id="Q5AK59"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="PRO" id="PR:Q5AK59"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990417">
        <property type="term" value="P:snoRNA release from pre-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232207" description="ATP-dependent RNA helicase HAS1">
        <location>
            <begin position="1"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="139"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="328"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="565" mass="63055" checksum="7ED2F3E6ED0FFF25" modified="2005-04-26" version="1">MAKTTKVKGNKKKSDTSKVVSKVSRKRSHEDSESEVEDNEKVVEELDADFDEVAGLLGDDIEDPESKSQSKKEKQKAKDEAKLEQLTKPQVSNEVPDNDNDDDSSEDVLFENADFSEPTMKAIKEMGFTKMTKVQAKTIPPLLAGRDVLGAAKTGSGKTLAFLIPAIELLYSLKIKPRNGTAVIIITPTRELALQIFGVARELMQFHSQTCGIVIGGADRRQEATKLAKGVNLLVATPGRLLDHLKNTQFVFSNLKALVIDEADRILEIGFEDEMKQIIKVLPNENRQSMLFSATQTTKVEDLARISLRPGPLYINVVPEKDVSTADGLEQGYVVCDSDKRFLLLFSFLKRNVKKKIIVFLSSCNSVKFYSELLNYIDLPVLDLHGKQKQQKRTNTFFEFCNAKQGILVCTDVAARGLDIPAVDWIVQFDPPDDPRDYIHRVGRTARGTQGKGKSLMFLTPSELGFLRYLKAAKVPLNEYEFPANKIANIQSQLTKLIKTNYLLNQSAKDGYRAYLQAYASHGLKTVYQIDKLDLKKVSASFGLDQVPRVNLSIGGTKTKKQKRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-03-19" modified="2025-06-18" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKU6</accession>
    <accession>A0A1D8PFT0</accession>
    <accession>G1UA00</accession>
    <accession>Q9UVW6</accession>
    <name>SSK1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Oxidative stress response two-component system protein SSK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SSK1</name>
        <name type="ordered locus">CAALFM_C113930WA</name>
        <name type="ORF">CaO19.12498</name>
        <name type="ORF">CaO19.5031</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Yeast" volume="15" first="1243" last="1254">
            <title>Identification of a putative response regulator two-component phosphorelay gene (CaSSK1) from Candida albicans.</title>
            <authorList>
                <person name="Calera J.A."/>
                <person name="Calderone R.A."/>
            </authorList>
            <dbReference type="PubMed" id="10487927"/>
            <dbReference type="DOI" id="10.1002/(SICI)1097-0061(19990915)15:12&lt;1243::AID-YEA449&gt;3.0.CO;2-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Mycoses" volume="42" first="49" last="53">
            <title>Histidine kinase, two-component signal transduction proteins of Candida albicans and the pathogenesis of candidosis.</title>
            <authorList>
                <person name="Calera J.A."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="10865904"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2000" name="Infect. Immun." volume="68" first="518" last="525">
            <title>Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans.</title>
            <authorList>
                <person name="Calera J.A."/>
                <person name="Zhao X.J."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="10639412"/>
            <dbReference type="DOI" id="10.1128/IAI.68.2.518-525.2000"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2001" name="J. Infect. Dis." volume="184" first="1170" last="1175">
            <title>Adherence and invasion studies of Candida albicans strains, using in vitro models of esophageal candidiasis.</title>
            <authorList>
                <person name="Bernhardt J."/>
                <person name="Herman D."/>
                <person name="Sheridan M."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="11598840"/>
            <dbReference type="DOI" id="10.1086/323807"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="Infect. Immun." volume="70" first="1558" last="1565">
            <title>Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis.</title>
            <authorList>
                <person name="Li D."/>
                <person name="Bernhardt J."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="11854244"/>
            <dbReference type="DOI" id="10.1128/IAI.70.3.1558-1565.2002"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="62" first="997" last="1013">
            <title>Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants.</title>
            <authorList>
                <person name="Menon V."/>
                <person name="Li D."/>
                <person name="Chauhan N."/>
                <person name="Rajnarayanan R."/>
                <person name="Dubrovska A."/>
                <person name="West A.H."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="17038117"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05438.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-513 AND ASP-556</scope>
        <scope>PHOSPHORYLATION AT ASP-556</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2004" name="Microbiology" volume="150" first="3305" last="3313">
            <title>Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter gene.</title>
            <authorList>
                <person name="Li D."/>
                <person name="Gurkovska V."/>
                <person name="Sheridan M."/>
                <person name="Calderone R."/>
                <person name="Chauhan N."/>
            </authorList>
            <dbReference type="PubMed" id="15470110"/>
            <dbReference type="DOI" id="10.1099/mic.0.27237-0"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2008" name="FEMS Yeast Res." volume="8" first="756" last="763">
            <title>Transcriptional profiling of the Candida albicans Ssk1p receiver domain point mutants and their virulence.</title>
            <authorList>
                <person name="Menon V."/>
                <person name="De Bernardis F."/>
                <person name="Calderone R."/>
                <person name="Chauhan N."/>
            </authorList>
            <dbReference type="PubMed" id="18616606"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2008.00404.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-513 AND ASP-556</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2005" name="Infect. Immun." volume="73" first="865" last="871">
            <title>Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils.</title>
            <authorList>
                <person name="Du C."/>
                <person name="Calderone R."/>
                <person name="Richert J."/>
                <person name="Li D."/>
            </authorList>
            <dbReference type="PubMed" id="15664927"/>
            <dbReference type="DOI" id="10.1128/IAI.73.2.865-871.2005"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2007" name="Antimicrob. Agents Chemother." volume="51" first="3747" last="3751">
            <title>The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole.</title>
            <authorList>
                <person name="Chauhan N."/>
                <person name="Kruppa M."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="17664325"/>
            <dbReference type="DOI" id="10.1128/AAC.00929-07"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5 7 8 9 10 11">Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to oxidative stress and probably also to the osmolarity of the extracellular environment. Involved in cell wall biosynthesis, hyphal growth, and virulence. Regulates the expression of CHK1, as well as of a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Provides at least partial adaptive functions for the survival following encounter with human neutrophils.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">Expression is detected as early as 1 hour after infection of reconstituted human esophageal tissue and increases thereafter up to 48 hours postinfection.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4 5 6 7 8 10">Leads to flocculation, attenuated virulence towards reconstituted human esophageal tissue, and to hypersensitivity to fluconazole and voriconazole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the SSK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF084608">
        <property type="protein sequence ID" value="AAD55813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722233.1">
        <property type="nucleotide sequence ID" value="XM_717140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKU6"/>
    <dbReference type="SMR" id="Q5AKU6"/>
    <dbReference type="STRING" id="237561.Q5AKU6"/>
    <dbReference type="EnsemblFungi" id="C1_13930W_A-T">
        <property type="protein sequence ID" value="C1_13930W_A-T-p1"/>
        <property type="gene ID" value="C1_13930W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636184"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113930WA"/>
    <dbReference type="CGD" id="CAL0000190567">
        <property type="gene designation" value="SSK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13930W_A"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008307_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AKU6"/>
    <dbReference type="OMA" id="QALIDWN"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="PHI-base" id="PHI:189"/>
    <dbReference type="PHI-base" id="PHI:3020"/>
    <dbReference type="PRO" id="PR:Q5AKU6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:1900442">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900428">
        <property type="term" value="P:regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:symbiont-mediated evasion of host immune response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000425802" description="Oxidative stress response two-component system protein SSK1">
        <location>
            <begin position="1"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="507"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1 9">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impairs filamentation and decreases virulence." evidence="9 11">
        <original>D</original>
        <variation>K</variation>
        <location>
            <position position="513"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Leads to sensitivity to H(2)O(2) and t-butyl hydroperoxide and decreases virulence." evidence="9 11">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10639412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="10865904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="11598840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="11854244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15470110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="15664927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="17038117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="17664325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="18616606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <sequence length="674" mass="73560" checksum="A9BBBE500DA64510" modified="2005-04-26" version="1">MNFLYNNSDYSSTSHTMKSPSAYNQFPKLQASNSTAGNNNTATTATAAAAAASASASASVTPQLISPTTLTTPQNKYKRGGLDNTLPKIETTRKNRPDDGNSITPSNSINSGTTKLTLPPRRVWVKKPQTNNPTTVLCYVNDIIDDLKVAVVNKYPNTIGRYEDAADLLVKIDLNNIRVPVSPSVNRVSQRTPFDNCIILEPDQNVWQILDNYFPNGMAMHDALIIETPTFKPDHQMLTPITANMNNNSNTFIPFQERQSSIGNNNNNNSNVNNNNKAQAVKHPQPMQPNNTRVGLHKSYAMNRSSFSTNNNPVPSIIKDRSVSPSNLGVSRNSPVSHKRSYSNPVSSPNSVATQANNPSAVLLLPRNFSLANNNSNQASQSSGGTPAKKVLSEDGSKSVNDKTEEVVSSKLKPNDNNKSYQAKQQEQQTAEQSENGFSETSASPEAVHNSKAAPLPLTKSSTTATTTSSNSISNNNNTSSKGKPSQSKLKAANDPTPTDIVLPSISVLVVEDNAINQAILGAFLRKRKIHYQIAKNGQEAIDKWKKGGFHLVLMDIQLPVKSGIEATKEIRHLEKLNRIGVFHENEIGKNVIINEEDRLTSNTFRSPVIIVALTASSNSSVDKTNALTAGCNDYLTKPVNLVWLQNKITEWGCMQALIDFDGWKDKNRRLNKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AM84</accession>
    <accession>A0A1D8PGG0</accession>
    <accession>Q5ALT3</accession>
    <name>SNU71_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>U1 small nuclear ribonucleoprotein component SNU71</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SNU71</name>
        <name type="ordered locus">CAALFM_C201820CA</name>
        <name type="ORF">CaO19.1491</name>
        <name type="ORF">CaO19.9068</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the U1 snRNP particle, a subcomplex of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SNU71 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722539.2">
        <property type="nucleotide sequence ID" value="XM_717446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AM84"/>
    <dbReference type="SMR" id="Q5AM84"/>
    <dbReference type="BioGRID" id="1218925">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AM84">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AM84"/>
    <dbReference type="EnsemblFungi" id="C2_01820C_A-T">
        <property type="protein sequence ID" value="C2_01820C_A-T-p1"/>
        <property type="gene ID" value="C2_01820C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635831"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201820CA"/>
    <dbReference type="CGD" id="CAL0000187181">
        <property type="gene designation" value="orf19.9068"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01820C_A"/>
    <dbReference type="eggNOG" id="KOG2253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478950_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AM84"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="PRO" id="PR:Q5AM84"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000333455" description="U1 small nuclear ribonucleoprotein component SNU71">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="614" mass="70502" checksum="91E2D6F7CC5055A2" modified="2017-05-10" version="2">MTAGDNSIEYVNPYSLSQTINSDLISILDPNGSTTSIIKPQLNYQIPIFKSIDVSNLIDLNNTKIQTQTNETRINKAKDSSDDHQNNPSSKDYDTSGENIVGGIDDIVEDIKLYVSIDKLKPENFQNQLTTIIINQFPTNLKSNLIEQLLKMLMNLKKFVWSFINHELIDLKLIFIKFDQLKDLKWFLLTYCDHISQLIPNVTIITNDKVNEYLNNNKDSSLAKVEPSKITDNLKAKINLIINNPINYTKGKKNSGTEDLDQVLDSYSNYKVDNNDLIDIPNNMKENIIKDIIRFRSRMLLIEKEQRKKEIEMERIKTKNKLKELFEGIKENSTDSTTRKATNKAAVGVTISPKVSHRDEYEDMNDKEYEEFIAVEERNKLNDQYNKKLKSFQNNQHAEYMKLTNKLKSLQNYESDLIDNKLKYIDNLKNYQTNGLAHLYTHNYSDYLRMRSQKRSLEETKDAEDVKQELEEIKKNGGQVASTNTNTNTKPSTYSSGVSELATTSVETPKSTTTTTTTNDTTDEPVAKKSKLAKEIIIIDLPPTVKQSLQEKIVELVENSLGIKDEFLIQVINENLEASNLDNKQELIDELVQVLDEDAESLVNELWDYIETMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APC5</accession>
    <name>Q5APC5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">SHY1</name>
        <name evidence="7" type="ordered locus">CAALFM_C109760CA</name>
        <name evidence="6" type="ordered locus">orf19.12304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723527.1">
        <property type="nucleotide sequence ID" value="XM_718434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APC5"/>
    <dbReference type="FunCoup" id="Q5APC5">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5APC5"/>
    <dbReference type="GeneID" id="3634824"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109760CA"/>
    <dbReference type="CGD" id="CAL0000182145">
        <property type="gene designation" value="SHY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09760C_A"/>
    <dbReference type="eggNOG" id="KOG1563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_4_0_1"/>
    <dbReference type="InParanoid" id="Q5APC5"/>
    <dbReference type="OMA" id="YLGTWQL"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000182145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="359" mass="41225" checksum="34FDFD9ACD4E1DD6" modified="2005-04-26" version="1">MFNIHTTRLVKLKPIRLLQFNRSVKTLTMDWKPMKAVPGNLRTLEHQSKMPTIRRVLLGLMYAMPIISFALGCWQVHRLQWKTDLIAKCENNLAAPVIPELPPNLDPSVIADFEYRRFKCRGRFDYDQEMFLGPRLKDGELGYLVVTPFIRKNGGDPILIERGWISKDKVVPSSRSSGYLSHLARPQGEIEIEALFRVMPKKSFLQLEHEQGSRLFHVPDVPAMAKQSGSLPIYCQMIYDLHDHIDWRKDENGQQQKPSVISSLLFSKKKDSDAAFIATNANKDETLQFQEFEFVNEGVPIAAKPFIKFSNNHLQYLITWFGLSIGSTVLLLFSIYKSKQFATAEQLLAAKRKDMQKKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q9B8D5</accession>
    <name>ATP9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATP9</name>
        <name evidence="4" type="ordered locus">CM_00140C</name>
        <name type="ORF">CaalfMp05</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="865" last="872">
            <title>Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.</title>
            <authorList>
                <person name="Anderson J.B."/>
                <person name="Wickens C."/>
                <person name="Khan M."/>
                <person name="Cowen L.E."/>
                <person name="Federspiel N."/>
                <person name="Jones T."/>
                <person name="Kohn L.M."/>
            </authorList>
            <dbReference type="PubMed" id="11208783"/>
            <dbReference type="DOI" id="10.1128/JB.183.3.865-872.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text>F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF285261">
        <property type="protein sequence ID" value="AAG59591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_075034.1">
        <property type="nucleotide sequence ID" value="NC_002653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9B8D5"/>
    <dbReference type="SMR" id="Q9B8D5"/>
    <dbReference type="FunCoup" id="Q9B8D5">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9B8D5"/>
    <dbReference type="EnsemblFungi" id="CM_00140C-T">
        <property type="protein sequence ID" value="CM_00140C-T-p1"/>
        <property type="gene ID" value="CM_00140C"/>
    </dbReference>
    <dbReference type="GeneID" id="802561"/>
    <dbReference type="KEGG" id="cal:CaalfMp05"/>
    <dbReference type="CGD" id="CAL0000186811">
        <property type="gene designation" value="ATP9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CM_00140C"/>
    <dbReference type="InParanoid" id="Q9B8D5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000021">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000356858" description="ATP synthase subunit 9, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000186811"/>
        </source>
    </evidence>
    <sequence length="76" mass="7790" checksum="07C2F17024E055A5" modified="2001-06-01" version="1">MQLALAAKYIGASIATLGLGGAAIGIALVFVALINGTSRNPSLRSTLFPQAILGFALSEACGLFCLMISFLLLYAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2025-06-18" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q9P975</accession>
    <accession>A0A1D8PU76</accession>
    <accession>Q5ACL6</accession>
    <name>IF4E_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Eukaryotic translation initiation factor 4E</fullName>
            <shortName>eIF-4E</shortName>
            <shortName>eIF4E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TIF45</name>
        <name type="synonym">EIF4E</name>
        <name type="ordered locus">CAALFM_CR10490WA</name>
        <name type="ORF">CaO19.7626</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-12" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans eIF4E gene.</title>
            <authorList>
                <person name="Ono N."/>
                <person name="Sudoh M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / CAI4 / ATCC MYA-682</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="AB036332">
        <property type="protein sequence ID" value="BAA93570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719387.1">
        <property type="nucleotide sequence ID" value="XM_714294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9P975"/>
    <dbReference type="SMR" id="Q9P975"/>
    <dbReference type="FunCoup" id="Q9P975">
        <property type="interactions" value="1351"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9P975"/>
    <dbReference type="EnsemblFungi" id="CR_10490W_A-T">
        <property type="protein sequence ID" value="CR_10490W_A-T-p1"/>
        <property type="gene ID" value="CR_10490W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638981"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10490WA"/>
    <dbReference type="CGD" id="CAL0000195194">
        <property type="gene designation" value="EIF4E"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10490W_A"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="InParanoid" id="Q9P975"/>
    <dbReference type="OMA" id="VKPRICL"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901195">
        <property type="term" value="P:positive regulation of formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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                <person name="Martchenko M."/>
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        </source>
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                <person name="Martchenko M."/>
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        </source>
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    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000200078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36806" checksum="DD218A35595841AC" modified="2017-01-18" version="1">MGFSLDICCTMFMASILRIYYYYCSPYESTLLRQSIIMILIQTLLLKVSLYYRPANYDPELLTSMPLLENELNMRVPRRLSSATLEHQSYWSGDWISSLGTITFDIIKYVSGYFIAYFNQGLRFFDVYYRRPLSFWQWKLEANYWWFVIGFSTVFGITTLIFHENVMYSNIIGVLGLFIESLLPLPQILLLNRLQSVKNFKVILLLSWLGGDCTKISYLLFGTDNISIIFIVAGLFQMSLDIYIAFQYLQFKYFTTTNKNLNDGASLHRRNQSIDDVVNDLVSVSSEIELDVLEKGQKDISNNQTSSWSRSRSSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDN3</accession>
    <name>A0A1D8PDN3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trp99p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">TRP99</name>
        <name evidence="10" type="ordered locus">CAALFM_C105410CA</name>
        <name evidence="9" type="ordered locus">orf19.8054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715859.1">
        <property type="nucleotide sequence ID" value="XM_710766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDN3"/>
    <dbReference type="SMR" id="A0A1D8PDN3"/>
    <dbReference type="STRING" id="237561.A0A1D8PDN3"/>
    <dbReference type="GeneID" id="3642494"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105410CA"/>
    <dbReference type="CGD" id="CAL0000177771">
        <property type="gene designation" value="TRP99"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05410C_A"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDN3"/>
    <dbReference type="OMA" id="SAWGKQH"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000159">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000177771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="184" mass="20154" checksum="5D4CA3D78D63E14F" modified="2017-01-18" version="1">MFSFTRAVPKSQLRFTVRNSFRTYVSIGDKVPATPVFEGSPGNDINLAEETASGKTILIGVPGAFSPACSASHVPGYIKNIRAFNDKGYQRFFVVAVNDPFVTKAWGEQLLESVAGQQIRFFADSTGAFTKELDLLFDARKAFGNERSKRYALIIEDGKVVKSFVEPDNTSVDVSAAQKVLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDT9</accession>
    <name>A0A1D8PDT9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C106480CA</name>
        <name evidence="6" type="ordered locus">orf19.6264.3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330660.1">
        <property type="nucleotide sequence ID" value="XM_019475115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDT9"/>
    <dbReference type="FunCoup" id="A0A1D8PDT9">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDT9"/>
    <dbReference type="GeneID" id="30515008"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106480CA"/>
    <dbReference type="CGD" id="CAL0000185928">
        <property type="gene designation" value="orf19.6264.3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06480C_A"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDT9"/>
    <dbReference type="OMA" id="PWTVFFN"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000185928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <sequence length="67" mass="7563" checksum="7EC51B198DFC00F6" modified="2017-01-18" version="1">MESARLSNYLEAAYIPPQKPTIKQEVPSYHPCLIVQDKQTDVTKLKPCGCADSYCVKNAPKWIPRAK</sequence>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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</entry>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="19 20" key="2">
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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        </source>
    </reference>
    <reference evidence="19 20" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
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        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:negative regulation of IRE1-mediated unfolded protein response"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001178">
        <property type="term" value="P:regulation of transcriptional start site selection at RNA polymerase II promoter"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
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    <dbReference type="FunFam" id="1.20.5.1190:FF:000005">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW1"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
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    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
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        <property type="entry name" value="SLIDE"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="SNF2_N"/>
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    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="SNF2-rel_dom"/>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
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        <property type="entry name" value="HELICc"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="144"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="444"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="17">
        <location>
            <begin position="813"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="991"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000192256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW26382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1017" mass="118676" checksum="6EB4498B520CAD61" modified="2017-01-18" version="1">MSSTEATPSLDLNDVLNDRNELSFQDNASKYFTKTEKQQVDIEKTSNRFKYLLGLTGLFRHFIEAKANKDPLFRKIVDNLHDSELKANKKKSDSARRRKTEKEEDAELLNDEKSTSSILEFTESPGYVHGQLRPYQIQGLNWLISLHENNLSGILADEMGLGKTLQTISFLGYLRFIRGINGPHLVITPKSTLDNWQREFNRWIPDIKVLVLQGDKDERAELIKNKVMTCDFDVIVSSYEIVIREKATLKKFDWQYIIIDEAHRIKNEESLLSQIIRMFHSRNRLLITGTPLQNNLRELWALLNFIVPDVFAENESFDEWFQKDSNNENGGEDQVVSQLHKVLKPFLLRRIKADVEKSLLPKKELNVYVKMSPMQKNLYQKILEKDIDAVNGANGKKESKTRLLNIVMQLRKCCNHPYLFEGVEPGPPYTTDEHLVYNSQKMLILDQLLKKFQQEGSRVLIFSQMSRMLDILEDYCYFREYQYCRIDGQTEHSDRINAIDEYNKPGSEKFIFLLTTRAGGLGINLTSADIVILFDSDWNPQADLQAMDRAHRIGQTKQVKVFRFITERAIEEKVLERAAQKLRLDQLVIQQGRNTGGLDGQQSSKAASKNELLDMIQFGAADMFQKTDGEGESIDIEQILKRSEERTQELNKKYAKLDLNALQNFTNDESVYEWNGENFKKKEPTANAQIPQVWINPGKRERKENYSIDMYYKDVLNTGGRTASNAPKSGPKPPKQLNVYDHQFYPAKVLELYELEKNYYRKQVHYKVPLKAGTDEASQKENELEQKLEQEEIENSRPLTDEEKQLKEELMQKGYSNWNRRDFHHFISLSTKYGRNSIRLIASEFEDKTEEEVREYAKAFWQNYQEIDGYERYINQIEQGEEKIIKVKIQKEALRRKLSQYRYPLQELVLKFPPASTNKRVFSEEEDRFLLVQLYRFGIDSPDVYDRIREAIRQSPLFQLDFFFQSRNAGEISRRCNTLLGCILKEISPEQSSMPATNGKRSKDSTPEVKNKKQKQT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE43</accession>
    <name>ZCF4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc cluster transcription factor ZCF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ZCF4</name>
        <name type="ordered locus">CAALFM_C107670WA</name>
        <name type="ordered locus">orf19.8813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probably acts as a transcritpion regulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716535.2">
        <property type="nucleotide sequence ID" value="XM_711442.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE43"/>
    <dbReference type="SMR" id="A0A1D8PE43"/>
    <dbReference type="STRING" id="237561.A0A1D8PE43"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PE43"/>
    <dbReference type="EnsemblFungi" id="C1_07670W_A-T">
        <property type="protein sequence ID" value="C1_07670W_A-T-p1"/>
        <property type="gene ID" value="C1_07670W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641799"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107670WA"/>
    <dbReference type="CGD" id="CAL0000189382">
        <property type="gene designation" value="ZCF4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07670W_A"/>
    <dbReference type="eggNOG" id="ENOG502QWIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE43"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463334" description="Zinc cluster transcription factor ZCF4">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000189382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="197" mass="22243" checksum="04DFFF517D84F0C5" modified="2017-01-18" version="1">MKLSTVGKIKRTRSKTGCLTCRKRKKKCDENKPKCNSCIHLNKECIWPSKDNIISTDTTTTSKRISKPTATDKNNMTKTNNKTTTLLKKIDTNNEESLIRHNPTTTTTTNTILLRTLNPQQLSSPNQEQYESDNNMVSLDSSITNSSIPKKSNYYLERIAMQQDCVEEDYIIPSLSQYIDVDGDGESVVNDQSNNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEI2</accession>
    <name>A0A1D8PEI2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dihydroxyacetone kinase</fullName>
            <ecNumber evidence="5">2.7.1.28</ecNumber>
            <ecNumber evidence="4">2.7.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glycerone kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Triokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Triose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">DAK2</name>
        <name evidence="22" type="ordered locus">CAALFM_C109190CA</name>
        <name evidence="21" type="ordered locus">orf19.12241</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.28" evidence="5"/>
    <dbReference type="EC" id="2.7.1.29" evidence="4"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723463.1">
        <property type="nucleotide sequence ID" value="XM_718370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEI2"/>
    <dbReference type="SMR" id="A0A1D8PEI2"/>
    <dbReference type="FunCoup" id="A0A1D8PEI2">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEI2"/>
    <dbReference type="GeneID" id="3634895"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109190CA"/>
    <dbReference type="CGD" id="CAL0000174642">
        <property type="gene designation" value="DAK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09190C_A"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEI2"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061610">
        <property type="term" value="P:glycerol to glycerone phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="8 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="20">
        <location>
            <begin position="11"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="19">
        <location>
            <begin position="391"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="17">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0000174642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AOW26553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="595" mass="64952" checksum="FC8A137566F47EAB" modified="2017-01-18" version="1">MTLAKHWKYGKDEDIVVTQLRGLVASNPYVNLIPSEKVVFNPHSDTSKKITIISGGGAGHEPMHGGFVGENLLDAAVSGSVFASPSTKQIMAAIKTKSNKEKGTIIVIKNYTGDILHFGLVAERAKSEGYKVELVIVSDDVAVGREQNKMVGRRGLAGTAFIHKILGSASATSPDVDLKSLSDLGHAINKNLVTLGASLDRTSVPGKLEEEIEFTGNDEMELGLGIHNEPGTKIKPIPNIDELIQKMYHQLLSPEDKDRHYVDFDFENDEYVLLINNIGGTSSFELYAIAEHALANLPLKKKPKRVYVSDFVTSFNSPGFSITLLNLSNLKKEDISFTDEDVLKFLDTPTNAPGWKPKIYDSEIWDSQNKEIESPMKNETLTSSDLKIDGQKFESQLVNALKVLLDEEPKITRYDTVVGDGDCGQTLADGANSILKALKEDDDFKSNLNDPVYTLGKITEYVEDSMGGTSGGLYSIFLTALVKQLKQTKEISVQSVGDALYHALYDGLFKYTRARVGGRTLIDTLQPFVDALHKTGDLTKAVEAANKGCEETKNLHASFGRASYVNEEEFKAEGGIPDPGAVGVLALIKGFTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF88</accession>
    <name>A0A1D8PF88_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C111760CA</name>
        <name evidence="2" type="ordered locus">orf19.8733</name>
    </gene>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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    </evidence>
    <sequence length="1220" mass="133963" checksum="E522AC510BE4FC40" modified="2017-01-18" version="1">MPTPAEIIAARLNRADATQNVYEEEEEEVVTSTETTPSTNAKPSITDEAAFPTLGGKKSASPVISNTGGASSWGPSMKTPVRSSTASPVPTPVQQTTPKPTNGIKSKVSTIQEAFSLDVEDQLNVARPEFIKILTFVKQETKTNIECTTSQHTKKRTFLITGRPDEVKLAKRLVIKKLTKPVKISFNIPAKLRSRVIGQGGKTLKPIIQANEVKIEIGDQVEGEDTGDDGTEEDEDEEEDIFAKTVQVTIDGDVEGSKRAKNAILAIVKEETKNLSAKVSVNETIKPFASKELKSIVDKYPTLEFAIPDYKSNRHTIIIVGERDLVLEAKPEVKAALEKLSNKVVVEEVPIPKIKQQFLPIEQVFEEHNVLIQLPKDGEGKVKFIGDKKKIAAAQASAKKTTSQYKVEILDMSKAHKGNLKHVKAVASVLTKTGVFDEIAKANDVTIHVPSSKDLESSATIPIEIVSKGDDEHIKVAKKAIVNQVNKITPDLTKTIEDIDEFLLNKVDETIKDVAKQQGVEYVVSGKIITLFNFQQSNEDAEDFDDVSDPDSAFKKVDEALNKLRELAANLTSATLSVPSKEQDQVSGPRGTTLKSILASVEPNTVTVELHQPTSDEVYIHGIKSSVATVKKEIESVLADAKEFGNEYSTTIQVPSQVLSRLIGKNGANLNQIRDEFGTRIDVPLEKDESKDKSSSKTEVTITGVKRNVEETKTKVSALAKRWADETLVRLRVESQYHRRMIGPRAVYINRLQDKYNVKIRFPSENSANFADAPNSKDEVTIKGPSKGVAKAEEELKELYAFEKENGFKQVVQIPLKAIARVIGKAGETINDIADGTGVEYTFNRDSEETKGHSEVELTGSKSALKEAVAKIQEIIDEVENFVSRSIKVEPIYHRDLIGPGGSIMKEIISKAGGDEVPRNRQYKLLNIPNEGSGSNEVTSQGDKNIVDKIIAAIEKIVEEKRASVTQEIDLPKEKHRLIIGPNGTIRHSLQSEFGVTIEIPRPNDESTVVKITGLPDKIDSAKAKIEELTKDDWNESIDVPAAYHVLVSERGAIFKKLKNDFNVEVAHGNFTRLANKLSAAPIPTPPESAYPQKDGELFKFTIVDANDSASATTAAASEEIIPWRLKGSEEATAKAAKFINEKLDLAKNSKSIGWFYASQPSVFSKVIGPQGSKVNQIRKKSNTFITVPRATDKNAANFIYLVGDEDNLNIAKKEIESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFB7</accession>
    <name>A0A1D8PFB7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C112150CA</name>
        <name evidence="4" type="ordered locus">orf19.12714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330707.1">
        <property type="nucleotide sequence ID" value="XM_019475162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFB7"/>
    <dbReference type="SMR" id="A0A1D8PFB7"/>
    <dbReference type="STRING" id="237561.A0A1D8PFB7"/>
    <dbReference type="GeneID" id="3642049"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112150CA"/>
    <dbReference type="CGD" id="CAL0000182264">
        <property type="gene designation" value="orf19.12714"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12150C_A"/>
    <dbReference type="eggNOG" id="KOG4493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFB7"/>
    <dbReference type="OMA" id="VCWEIWT"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000182264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="202" mass="23219" checksum="5EB6D0D81054C9C8" modified="2017-01-18" version="1">MEFIINVIAERSVLRESLKGIIWTIFFNRLFGPITPVTNEFMNVSYPMANNLPDLDSLIDEKVNRILNQITEVSNQAKINVQFLSKSSNKKKTGWFGNSTYNAQDDLVVWESWLINVESLPLDQVSNGESKNVQTSIQNFANNLTRIYDIADKFKEHIPPITSLDSAPFPYKIIIPEKKSHHNRDYHTGEEGWGTYIKKILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFU6</accession>
    <name>A0A1D8PFU6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">APL1</name>
        <name evidence="10" type="ordered locus">CAALFM_C114040WA</name>
        <name evidence="9" type="ordered locus">orf19.7212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715013.1">
        <property type="nucleotide sequence ID" value="XM_709920.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFU6"/>
    <dbReference type="SMR" id="A0A1D8PFU6"/>
    <dbReference type="FunCoup" id="A0A1D8PFU6">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFU6"/>
    <dbReference type="GeneID" id="3643342"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114040WA"/>
    <dbReference type="CGD" id="CAL0000195418">
        <property type="gene designation" value="APL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14040W_A"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFU6"/>
    <dbReference type="OMA" id="FIQRPTR"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001382">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="93"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000195418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="767" mass="87365" checksum="66ADF4A33F63C12B" modified="2017-01-18" version="1">MDLASLIFSNRVNTCADISLQLQSNSLFFFPSFHKSNIIWSSLFVILFFFKTKLNKTLTSSTHLFIIISYNTIDIRKMSDGKLFTRSKTTELRTELEQAFKKSKPVVRVKVVLKKVLANIILNNHEVTNLMKDIIPLMKIDDLEVRKLCCEYISTYATTNPDAEDAIPFFSRFHSDPNPLLRVLSLKTMVSINRKEFLNLSITSCKRSFSDKDPDVRKSAAYAAGQIYQHDPARAEREGLIELLNQSLYDENSSVISSALASLGTVIENSKTLNLKIDKNHALTLIKLLRATNEWQQTYILNALMSYTPQNEDEALNLIEAVLPSLQHENSSVVMNAIKVVIYYCNYARNPELRLPVLPKRLGTSLVSLLSKPAETQFLVLRNVILLLLGRKEFVHFDVEMFYCRFDDPIYVKDTKLEIIYLLANESNVGSVLRELEEYATEVDVSMARKAIRAFGNLAVKLENAAEQCVEVICDLVSNGISYIVQESAIVIKNILRKYPGQFEFAISELIKHYKLIDEPDAKTAFVWILGQYCQNIKESKSILEDFITSFKDDPLDVQYATLTAVAKYYLKFPEQGESVILRVLKWATEEVDNPDIRDRGYIYWRLLSSEHASGPNGEFQLNTKKIILNDNPVITSENDNINPVILEELELNIGTLASIYLKPVQTVFRLSKHKELPYSPALQRRNSFHSGVATPQPQSRNSKEHSPGAGAGVSRRMSYRRTNSDNGSQRSTHFDETTNTQQHMPRENLAQKFSRKASFITNRIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFW9</accession>
    <name>A0A1D8PFW9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sphingolipid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">NCR1</name>
        <name evidence="16" type="ordered locus">CAALFM_C114300CA</name>
        <name evidence="15" type="ordered locus">orf19.7242</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715042.1">
        <property type="nucleotide sequence ID" value="XM_709949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFW9"/>
    <dbReference type="SMR" id="A0A1D8PFW9"/>
    <dbReference type="FunCoup" id="A0A1D8PFW9">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFW9"/>
    <dbReference type="GeneID" id="3643314"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114300CA"/>
    <dbReference type="CGD" id="CAL0000182780">
        <property type="gene designation" value="NCR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14300C_A"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFW9"/>
    <dbReference type="OMA" id="WWFDVES"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111066" evidence="13">
        <location>
            <begin position="29"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1196"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="14">
        <location>
            <begin position="582"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000182780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1256" mass="141105" checksum="89AF8C4E2ABF5286" modified="2017-01-18" version="1">MEFFSSSLILQAMRAICLLLLTINLAIASVSSSHKPGYCNTYGNCGKKSVFGKPLPCAEFVPAVKASQESREKLKSICGKDFDYICCSPEQIDILESNLKRVDPLISSCPACRKNFYDFFCQFSCSPNESQFVEIIKTETARDTGKEIVTEINQYVEPGMANQFFDSCKNVKFSATNGYAMDLIGGGAKNYSQFLKFLGDEKPLLGGSPYQINFVYKLPETDSGLVLRNEPLRDCNDKEYKCACTDCEESCPKLPHAKDLTKKCTVGVLPCFSFSIIIIWSCMIVLLGGYHVYLAKLKKERRRSIAEDSEDDESTMINPLFYAGLGKKRAKQFSSEIGSKIQDWFANIGYFCSKFPGISIGTSLAVVVLLSLGLFKLQLETDPVKLWVSPNDPAYKNQQYFESNFGEWFRIEQVIVSSKDDGPVLNWDIVKWWFDKESQLETLNENVRLSDICFKPLDETCALQSFTQYFQGDISGLTETNWKSKLQSCVDSPVNCLPTFQQPLKPNILFDSNDISQAKAFTVTVLVNSDTQNENYTSNTISYEHSFQKWAADLQTEYPNLNIAYSTEISLKEELNQSSNTDIKTIAISYLVMFIYASLALGGKLPSANLYSLVKTRFTLGFSSIIIILLSVTASVGFFSIIGLRSTLIIAEVIPFLVLAIGIDNIFLIVHELHVISEGNPNLALEVRISQALKHIGPSCFISAVLQVCMFLLATSVGMPAVKNFAYYGAGAVLINFSLQMTCFIGLLALDQRRLEDNRVDYVPWVTISPIQLQDNDEIDEPVHLEYNFSRWIGDHYAPFLLKKTTKPKVITLFVLWVGISLSLFPKIQLGLDQRIAIPSKSYLVNYFNSVYDYLNVGPPVFFVVKDLDYSERSNQQKICGGFSACDEFSLANILEQEFKRSDISMLSEPASNWLDDFFSWLNPDLDQCCRFKKSTVFEKTPEFCSPNAPQRQCQSCYLNHNPPYDSSMKAFPERDFMFYFNDWIQEPSDPCPLGGKAAHGQAISRTTEKIDSSYFRTSFAPLRGQDEFINAYKSGNNIVKEITKLIPSMDVFAYSPFFIFFTQYQNIVLLTVALLTVAMLIIYVISTFLLSSFRAASILTITITAIMINIGGVLALWSISLNAVTLVNLVICVGFAVEFTIHLTRAYCVPKVKMFDNPAEEELYNNLVNAEPENTRRSSITSLNAEFRNTKAHNALCSVGGSLISGVTLTKLIGISVLAFTRSQIFEVYYFRMWLSLVVISFVHAFVLLPVLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGF0</accession>
    <name>A0A1D8PGF0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">PLB4.5</name>
        <name evidence="13" type="ordered locus">CAALFM_C201380WA</name>
        <name evidence="12" type="ordered locus">orf19.9017</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722492.2">
        <property type="nucleotide sequence ID" value="XM_717399.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGF0"/>
    <dbReference type="SMR" id="A0A1D8PGF0"/>
    <dbReference type="STRING" id="237561.A0A1D8PGF0"/>
    <dbReference type="GeneID" id="3635724"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201380WA"/>
    <dbReference type="CGD" id="CAL0000174502">
        <property type="gene designation" value="PLB4.5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01380W_A"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGF0"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009026855" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="44"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000174502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW27184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="702" mass="77036" checksum="41D49243CC8C753D" modified="2017-01-18" version="1">MNLLISLLLLSISLVLGSSPSGGYAPGIVQCPINSNSNSSSSSSRNTTFSFIREADSISDLEKQWIKQRQLKVNKSLIEFLKSANLSNFNPQNFIDAKDYQGINLGLAFSGGSYRAMLNGAGQLMALDSRSSSSPSESGSGSGSLGGILQSANYIGGLSGSSWLLGSLAMQGWPTVEEVVFENPHDVWNLTSSRQLVNQTGLWTIVFPVMFDNMNKALSHMNFWDNNADGIKFDLEAKEKAGFETSLTDAWARGLAHQLFPKGKDNYGSSETWSDIRNIDAFANHDMPFPFVTGLGRKPGTTVYNLNSTVIEMNPFEFGSFDPSLNTFTDIKYLGTNVSNGVPVDSCVNGFDNSGFIVGSSSSLFNSFLNTLVCDNCNSLSSVIKWILKKFLTYLSKAHEDVALYKPNPFFNSQYAKSDNITTSDTLYVIDGGIGGEVIPLSTLMVKERALDIVFAFDSDTNTKTNWPDGSALISSYERQFSQQGSSSICPYVPDTKTFLEKGLTAKPTFFGCDAKNLTALEKDGVIPPLVVYFANRPYEYYSNVSTFDLTFTDEQKKGLIKNGFDVATRLNGTIDPEFKSCIACAVIRREEERRGIEQSDQCKKCFKNYCWDGTYASGPAENYVNFTDSSLTNGSTVFYGKADAKVSSSKGGLFGFLKRDTQNNDEKEEFIGVVRESNSDSLKLSKYLTIASLFALYLVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGL8</accession>
    <name>A0A1D8PGL8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zn(2+) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZRC1</name>
        <name evidence="11" type="ordered locus">CAALFM_C202200WA</name>
        <name evidence="10" type="ordered locus">orf19.9111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722581.2">
        <property type="nucleotide sequence ID" value="XM_717488.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGL8"/>
    <dbReference type="SMR" id="A0A1D8PGL8"/>
    <dbReference type="FunCoup" id="A0A1D8PGL8">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGL8"/>
    <dbReference type="GeneID" id="3635772"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202200WA"/>
    <dbReference type="CGD" id="CAL0000192596">
        <property type="gene designation" value="ZRC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02200W_A"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGL8"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="PHI-base" id="PHI:8106"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071577">
        <property type="term" value="P:zinc ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="9"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000192596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="478" mass="52546" checksum="FF9A07B12001E568" modified="2017-01-18" version="1">MNSKEIRIVALLILDTVFFLLEAIIGYTVHSLALIADSFHMLNDIISLIIALWAVRVKNTKPADGKYTYGWQRAEILGALINAVFLLALCFTIIMDSIQRFFEPQEISNPKLILIVGIAGLVSNGVGLVLFHEHGHSHSHGGGGGGGSDHSGDSKSHSHSHSHSHGEATTFSQGDEEEHIGTEENEHTPLLYNITHTTMKSTPSEVFDYLPDNVVERYSNYQPSFSGQSPLNGTSANSSDANTVVNNNNTSDHSGTNNNTPQSALQKIKQKSMNMEGVFLHVLGDALGNIGVIITALVIWKTDYSWRFLADPITSLFITLIILNSALPLVRKASRILLQSAPPYIDSNLIVNQIKQLPLIKNIHDFHVWNLNEDILIASLHIELNPNCEVNLPLPLPSNGGDNNNNNTKNGSNGDSSIDEEQDQDQELELEEAPSQIDRKLFLAAVGQVREVLHIYGINSVTIQPEFSNSKKVCRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHR0</accession>
    <name>A0A1D8PHR0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">VAS1</name>
        <name evidence="16" type="ordered locus">CAALFM_C206640CA</name>
        <name evidence="15" type="ordered locus">orf19.8875</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710060.2">
        <property type="nucleotide sequence ID" value="XM_704968.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHR0"/>
    <dbReference type="SMR" id="A0A1D8PHR0"/>
    <dbReference type="FunCoup" id="A0A1D8PHR0">
        <property type="interactions" value="1270"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHR0"/>
    <dbReference type="GeneID" id="3648340"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206640CA"/>
    <dbReference type="CGD" id="CAL0000181624">
        <property type="gene designation" value="VAS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06640C_A"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHR0"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000120">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="168"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="839"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000181624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1119" mass="127555" checksum="22D6C95F2C8D357B" modified="2017-01-18" version="1">MLYSRNLLLSTSSILFRKRIDFCIRRKLLSSSSIITNNMSDSSTNPPPPPHPAAAAAAAAAAAEQPVATTPQEGQPKQKTAKELEKERKKAEKLAKFNAKKAKQAAEANNKPKKDQQKDDKKTKKANTPTTKIPEFVDKTVPGDKKILVSLDDESFKAYNPKNVESSWYSWWEKQGFFEPELTANGEIKKEGCFSIPCPPPNVTGALHIGHALTVSIQDTLIRWNRMQGKTTLFIPGFDHAGIATQSVVEKQIWAKEQKTRHDYGREKFIEKVWEWKEEYHQRIKNQFKKLGSSYDWSREKFTLNPDLSQAVTEAFVRMHEDGTIYRASRLVNWSVKLNTAISNLEVDNKTIPGKTLLSVPGYESKIEFGTLTSFSYPVVDSETNEKLTVATTRPETIFGDTAVAVHPKDPRYTHLHGKFVQHPFLDRKLPIICDAETVDMEFGTGAVKITPAHDQNDYNTGKRNNLEFINIYTDDGLLNENCGPEWKGMKRFDARYKVIEQLKQKGLFVDQKDNEMTIPVCSRSGDIIEPLLKPQWYVDQKQMAKDAIEVVKRGEIVINPKTSEAEYFQWLENIQDWCISRQLWWGHRCPVYFVNIENEQIHDKLDNNYWVAGRTEEEAFKKAQEKFPNKKFTLEQDEDVLDTWFSSGLWPISTLGWPNETKDMELFNPMSMLETGWDILFFWVSRMILMSIKLTGKVPFKEVFCHSLVRDAQGRKMSKSLGNVVDPLDVINGIPLQGLHDKLLTGNLDPRELKKATEGQKLSYPNGIPECGTDALRFALCAYSTGGRDINLDILRVEGYRKFCNKIYQATKFVLGRLGQDYIPPTTSELTGKESLVEKWILHKLSHAAKLTNESLEARNFGDATNHIYNFWYDLCDVYIENSKSLIQDGTPEQKKSAQDTLYTCIDGALRLIHPFMPFITEEMWQRLPRREPEITGNLKTIMKAPYPVYKSEFDDIKSLEAYNLVLDITKGARSLLSQYNILKNGQVYVETNNEEIYKIANDQQDSIVSLIKGVEKITVVKTLDQVPSGCALQAIGPECTVHVLVKGQIDLDAEIAKVEKKLSNVLEQKKKTDESISKFTEKTKPEAKDSAYKRLEKQTAEIEGYEQTIAILEKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHT8</accession>
    <name>A0A1D8PHT8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C207110CA</name>
        <name evidence="2" type="ordered locus">orf19.9806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
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    </evidence>
    <sequence length="405" mass="46230" checksum="06DA2B9D5DD10C2E" modified="2017-01-18" version="1">MSFPPLENPNLEGYEIARQLWIEYYNQREGTFVARKKCNGCYNENKFVVWAVAVAAQAIVDGARIYPELKPLVGPAIQIFQKYKNNHIKGYSAAENSGNDQDIYYDDDAQVASAIITAYEVTGDKSFLDQGRELVRFLMSGWNDKPDAKTKGGVHWHVSKNYLNACTTAEVAKACLQISKFLPEEAGVYIDFAAKCIDWQIQVLQDPGDKLIKDGVSDKDTKINDVKWTYNVGTTLSAAAHLYFITKDDKWKQISQDLAKAGINRGVFFYDRDFDNSKRYWRDSSYFVQLLIEGLADYLLYVGNDVPDELVGKIQEEIKRHLIIFYEFMKDPKDGMYIQSFEPHNTYREVYDQKYKNFFGDGKGWGLKGEDKDENGNPSKCLMGYAAAARVFFQGARVVPHIDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJL3</accession>
    <name>A0A1D8PJL3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C302760CA</name>
        <name evidence="3" type="ordered locus">orf19.7899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719965.2">
        <property type="nucleotide sequence ID" value="XM_714872.2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJL3"/>
    <dbReference type="GeneID" id="3638413"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302760CA"/>
    <dbReference type="CGD" id="CAL0000201102">
        <property type="gene designation" value="orf19.7899"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02760C_A"/>
    <dbReference type="eggNOG" id="ENOG502QW4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJL3"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019211">
        <property type="term" value="F:phosphatase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043185">
        <property type="entry name" value="Net1/Tof2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000201102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1213" mass="130031" checksum="4EE28775C4DC1A76" modified="2017-01-18" version="1">MSKIKLKALLIPKEFEQIDASNIDPRKYVKFLYLVDRTANIESLEEGLITRFSKRYPRERKLRVLAFQNKDLCDLDPEFAVEDVFNESNDELRVLVDNKFKSITYTPEPAISTPINFSQAETIRGGVYSTVDITDDKTTPKKSKQSPLSSPVSLAPPPESRSNRKIPQKKKSVSSLKQRITSGMLEAPPATPMNNPDKVYFDERSFTSPKKKQQKAKKNDSFVASSSLDEVSSGDEYKESEESAAETADYEPEEEEKIQPEELLSMYEELDFHENDDLPLSQTSNPKHSTINKALQIDMVEGNPAMYLSRTKRRAAREANLVFTSSKKAAKTPSSTPKPASTIKTTPKPGKVQKSTPTTKQKHTSPVVGVNGQSKSLPKPTQTAGTEKKSSISTSSKQAKTTVGKAQTKATPVTHTKTALTTTSQSSNKALPKSTNKPSVSKSTLEDLYDRMKVFGQKVKTLMVHGEDGNIIGYEKIPNDFGDGIQLAHDISSEAIDTALRLTVQKDSQDSDIVKTEEKVSNPEPISSNPEPSLQPVEKIVSISSDTEVKSKTSANNLDSEDTDDIVIKPPVKNRKTGSTKAASKDLDSDDDLKEIASATAPPNVTSTKPISKESDSHVANDNGSDSDDIDIKAADAAFVPAKISTATSAPISTNVNSNVANDNGSDGIDIDIKAADAAFVPAKISTAASASIVNNNAANESDSDDIDIDIKTASAAFVPVKTGTASSASIVNSNVANESDSDGVDIDIDIKAAGQAFVPVKTGTTEALAPIVNRKVTNDSDSDDMDIDIKTAGAAFVPTRSGTTETSAPIAIIVDSSEEETGNNKTGNNTISISREQLKTFAKIINKSKMGSGSFSNNSSNGQDVVDNKILPDTAPSAFAGMVEISDDGNGISGNNTPNRLNYDDNESYIPKSFASNFRAHERKTQALGSLQIVHQDPVVDKTPTKNYELASDNMLSYIYVGDSGGEDINAVGRGIDDRSRGYNKSSDPSSPFGKTDTSSSFLFGGGGSSTNANTSIPKPAFGAGDLFATKPNNGNGTNNRNDYSMGNNNGNSSISVGGINANNTTGSEWNNNNTHRNGTGATSGSVLSNKTSNSNDQNSSIPSAQQQANNNINSATRAALSRLSSLQNLVNSNKRSRPDSESEESDDGEDEEDEDHDEPERVRKKSKLIASTPIPKPIMTPLSGNGNKLRSNLIPWSSKAKPIIPKXNTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJN3</accession>
    <name>A0A1D8PJN3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="20">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DNF1</name>
        <name evidence="25" type="ordered locus">CAALFM_C303250WA</name>
        <name evidence="24" type="ordered locus">orf19.7955</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="20"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720018.2">
        <property type="nucleotide sequence ID" value="XM_714925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJN3"/>
    <dbReference type="SMR" id="A0A1D8PJN3"/>
    <dbReference type="STRING" id="237561.A0A1D8PJN3"/>
    <dbReference type="GeneID" id="3638318"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303250WA"/>
    <dbReference type="CGD" id="CAL0000175287">
        <property type="gene designation" value="DNF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03250W_A"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJN3"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099039">
        <property type="term" value="P:sphingolipid translocation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000035">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 19 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1107"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1189"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1227"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1254"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1295"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="1075"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="17">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="718"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="899"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="900"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1023"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1029"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="1049"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="1052"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="1053"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <position position="1053"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="CGD" id="CAL0000175287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AOW28354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1479" mass="168526" checksum="66F267BE5408E9FD" modified="2017-01-18" version="1">MSESKDQSTDSTGSPGLQSRGEPQPPSFKEKIHRFFFLKGLADRPPYLQEIYDNTPRTVFYNYDLPDYMIDSQGRPITQYPRNKIRTTKYTPITFLPKNLLLQFTNVANSYFLLIVILGAFQIFGVPSPGLAAVPLIVIVCITAIKDAVEDYSRAASDAELNNSPIHLLTGVHNPNVLVDQVGPWRRFKKACSRGTARVFKFIKKCCIFICGSKRVKQEYAREQVQEDNLALHRVSTVVSDYTYRSQEPRYSVSSPRRSMNTNRRSIQSSHHRPTVALPNSLLNPILKKENAQNPSSIRANFKNRCWKDVNIGDIIRIRANEEVPADVIIISTSDSEGNCYIETKNLDGESNLKTRTALKCGGNNNLKHSDDLSDTKFWVECDAPNANLYSFKGTIHYENFDSKGNLVNEDEKEAITPENVLLRGCTLRNTKWVIGFCIYTGPETKIMLNSGITPTKTSRISRELNLSVIINFILLFVLCFVSGLINGLFYRNENNSRVFFDFHPYGKTPAINGVIAFWVALIIYQSLVPISLYISIEIIKTIQAYFIYADVKMYYDRLDFPCIAKAWNISDDLGQIEYVFSDKTGTLTQNVMEFRKCTINGKSYGLAYTEAQQGLDKRAGIDVIENANKWKNKIAADKEVMMDDLTKYSNNDQLREENITFVSSQYVRDTFLGDSGDDQKQANERFMFALALCHTVMTEESESDSTLRDFKAESPDEAALVSVARDMGIVFKKRLRSSLLLEIYGEEQEFHLLDIIPFTSARKRMSCVIKTPDNKIILYTKGADSVIFQRLNPRENPNELVSKTALYLEDYANEGLRTLCIASKVLDPQVYDNWNKRYREASSSISDDREVLMGQLEEEIEQDLVLLGGTAIEDRLQHGVPQSISILSEAGIKLWVLTGDRVETAINIGFSCNLLENDMKLLVVRPESNDTQDCEQIDDLITKYLQEEFHIDASSPSLVADAIKQARKDHSIPQAKVALVIDGAALSLIFQDLKDCPNDTIRVLQDKFLLLGKQCRSVLCCRVSPSQKAQVVKLVRTGLQVMTLAIGDGANDVAMIQAANVGVGIAGEEGRQAVMSSDYAIGQFRFLTRLLLVHGRWSYKRLAEMIPCFFYKNVVFTLTCFWYGIYNNFDGSYLYEYTYLMFYNLAFTSLPVIVLAVFDQDVSDTISLLVPQLYTSGILGKDWSQYKFVWYMFDGLYQSVISFFFPYLLFYLAFQNPQGMTIDHRFYMGVVAACIAVTACDIYVLMQQYRWDWLSVLIDCISILLVYFWTGVWSVNATYSGEFYRAGAQTLGTLGVWCCIFIGVIGCLLPRFTFDFFTSNFKPADVDIIRERVRQGAYDDYPLGYDPTDAEDVERHRLLTEIINKDPQLFEKMENEYKEEEHDKETPLERTFKSIKRRTTISRSKKGTAQRLRRDTINDQFQKHIPLDELRQQMIKEGEYTSARYSLDRINTTHEIPGVTQADTLLKYHTRNSVALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJV5</accession>
    <name>A0A1D8PJV5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metal homeostatis protein BSD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C304260WA</name>
        <name evidence="7" type="ordered locus">orf19.13290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000195495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="696" mass="78184" checksum="6B0FCE741DCCEA88" modified="2017-01-18" version="1">MSFNQQSPNFSSSSGMNANTPQQQQQQRGGNLPALTPQMLQSLTPQQFQLFRSNPQFQEVMNQYMQKQQLLQQQQQQQQQQQQQGSPHLMNGIPNQPQANPQFRQQVVANQMPPNMVNVPGSQTIINQPIHGANIPINKVPSRRMSSIPGIPGGQNPPVGVPGGAGPLLAGVPGATPLVPGQGPACSVGGVLATGVPNPGGVPSTGTLNGAHGNAGLNTNLPPGVTPEILNKVPMKPMQNVKEWSEKLKQEGKDVPLDLKVYEDLIRKDKEFVGKLNKQLHDNKFIMENINRDIKSYNQIKQLRMNSIALSNKGQYNNSIWGEGYQGYGNGITNSSTKLFIPNRDLTDRIINERVMKNKNKPKHYVPIRLEFDQERDQFKLRDTFLWDLNEEIIKVEDFTAQLLEDYKFISKVHYETILSSIKEQIADYSQKPSKTMGELRIPIKIDITINNTQLTDQFEWDILNSQEGDAEEFSSYMCDELCLPGEFCTAIAHSIREQSQMYYKALNMVGYGFDGSPVHEDEIRNHLLPPLRLVSSDSGIVDDFFSILRNPSSLPDFSPTLGKLSQLEVERLDKEMERESRRKRRHNYNEDQQQGSGRGFTSRRIAAHAGRGNTIPDLSDIPKTFRTPAPSSILPGAVDMGVPEVYEYNEVLINRTQVRNPDYRPPTPIRVENELVDYNHDPIEGTFMVTIKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK74</accession>
    <name>A0A1D8PK74_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tea1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">TEA1</name>
        <name evidence="11" type="ordered locus">CAALFM_C305470WA</name>
        <name evidence="10" type="ordered locus">orf19.6985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714691.1">
        <property type="nucleotide sequence ID" value="XM_709598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PK74"/>
    <dbReference type="FunCoup" id="A0A1D8PK74">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PK74"/>
    <dbReference type="GeneID" id="3643671"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305470WA"/>
    <dbReference type="CGD" id="CAL0000184514">
        <property type="gene designation" value="TEA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05470W_A"/>
    <dbReference type="eggNOG" id="ENOG502QTSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PK74"/>
    <dbReference type="OMA" id="YMADHFI"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="CGD" id="CAL0000184514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="900" mass="102641" checksum="069776CB63F5106F" modified="2017-01-18" version="1">MSINSSTSTTNKRKRKNPSTTTPPPPTTPHPAPPRTEKRISCQRCRTRKIKCNYELPCFNCKRDGSQCIQPIDMRSKRLKATEVITLQKKLDLMIKFINDCKKLPNAEAKQQFISQTNLDELINDGSIVLDNGDSTNGDGDVLHVANHDEDVTHNNSAIYGPTSVYDDSLMHNHKPNTKHKQITIDKSNSNDDNNSKGEINKDENRNVGNNSSINYNNNINTLNNRIDNNSSNLINVINKMNKDPDILKCIQLFFIWQYPDHNMFIFREAFLIDFFNPKKNMLYCSKTLILSICSLGAKMSTEETIYNRSKEFYQESKYLLLNSLHQPSITSLQSFMLLAFYDICNGQNSSGWMLSGCAMRMGYDLGFQLNPELWFVKSKGENNTINNLSKLDVEIRSRIYWGCYMADHFISLLLGRPSILKISDASIPVTSDLPDLEWIDDFTYNGYIKKKKLHKRSKSKHRKDEHEDDKDDLKSPGKHKHQEVSYISDPLNQIINLINISDNILNDIFTKTDEEQPQEHQQEQQQQQQQQQQKSNEDLNLKSRWEKLSQYNSQIMAWKKNLPKDLRWNRTKLGKTGENPTYSGIRYYYYILLLCLNRPFVGIDQDNHNNHDTNNNDNNDNNDSDDSDDNLSPLSICLNAIDDLYESINRFQKKHGYRGGSIFIVYSSILSISILLLTNSRIQLASEQKNRLHFFMDVLYGCSKTWKLAEKSYNLITEKLKHLYEAGELKDVFEFIIEKKSSPSATNTSGNGLNEASGNNNNNNSQSIESNEFKLPINNKTLSKLKHNQQNTNNSLPTYDTTDTINSTSGATTTNNSTTFSMDQNLMEAPTPLSTISNGVNNNNNNGGGGGGRNSSSATDFLTDDNVDFLGGPPVLMTADLFNEDWEALFPDYIFNSKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKB4</accession>
    <name>YCK2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine protein kinase YCK2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Casein kinase I homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YCK2</name>
        <name type="ordered locus">CAALFM_C305650WA</name>
        <name type="ordered locus">orf19.7001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-11" db="PDB data bank">
            <title>Crystal structure of Yck2 from Candida albicans in complex with inhibitor 1f: 7-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF 37-345</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2024-11" db="PDB data bank">
            <title>Crystal structure of Yck2 from Candida albicans in complex with inhibitor 2a: 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine-6-carbonitrile.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 37-345</scope>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-11" db="PDB data bank">
            <title>Crystal structure of Yck2 from Candida albicans in complex with inhibitor 1e: 2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine-7-carbonitrile.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 37-345</scope>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2024-11" db="PDB data bank">
            <title>Crystal structure of Yck2 from Candida albicans in complex with inhibitor 2b: 6-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 35-345</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="4393" last="4403">
            <title>MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Ramsdale M."/>
                <person name="Selway L."/>
                <person name="Stead D."/>
                <person name="Walker J."/>
                <person name="Yin Z."/>
                <person name="Nicholls S.M."/>
                <person name="Crowe J."/>
                <person name="Sheils E.M."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="18653474"/>
            <dbReference type="DOI" id="10.1091/mbc.E07-09-0946"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1498" last="1510">
            <title>Transcriptional responses of candida albicans to epithelial and endothelial cells.</title>
            <authorList>
                <person name="Park H."/>
                <person name="Liu Y."/>
                <person name="Solis N."/>
                <person name="Spotkov J."/>
                <person name="Hamaker J."/>
                <person name="Blankenship J.R."/>
                <person name="Yeaman M.R."/>
                <person name="Mitchell A.P."/>
                <person name="Liu H."/>
                <person name="Filler S.G."/>
            </authorList>
            <dbReference type="PubMed" id="19700637"/>
            <dbReference type="DOI" id="10.1128/EC.00165-09"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="9 10" key="10">
        <citation type="journal article" date="2020" name="Cell Chem. Biol." volume="27" first="269" last="282.e5">
            <title>Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.</title>
            <authorList>
                <person name="Caplan T."/>
                <person name="Lorente-Macias A."/>
                <person name="Stogios P.J."/>
                <person name="Evdokimova E."/>
                <person name="Hyde S."/>
                <person name="Wellington M.A."/>
                <person name="Liston S."/>
                <person name="Iyer K.R."/>
                <person name="Puumala E."/>
                <person name="Shekhar-Guturja T."/>
                <person name="Robbins N."/>
                <person name="Savchenko A."/>
                <person name="Krysan D.J."/>
                <person name="Whitesell L."/>
                <person name="Zuercher W.J."/>
                <person name="Cowen L.E."/>
            </authorList>
            <dbReference type="PubMed" id="31924499"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2019.12.008"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 37-345 IN COMPLEX WITH INHIBITOR GW461484A</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase required to cause normal damage to epithelial cells and resist antimicrobial peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Expression is activated in weak acid stress or on contact with host cells.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Impairs virulence and morphogenesis (PubMed:31924499). Causes a significant decline in fungal burden in a model of systemic caspofungin-resistant Candida albicans infection (PubMed:31924499).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714706.1">
        <property type="nucleotide sequence ID" value="XM_709613.1"/>
    </dbReference>
    <dbReference type="PDB" id="6U69">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.61 A"/>
        <property type="chains" value="A=37-345"/>
    </dbReference>
    <dbReference type="PDB" id="6U6A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A=37-345"/>
    </dbReference>
    <dbReference type="PDB" id="9EDV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.42 A"/>
        <property type="chains" value="A=37-345"/>
    </dbReference>
    <dbReference type="PDB" id="9EDW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.33 A"/>
        <property type="chains" value="A=37-345"/>
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    <dbReference type="PDB" id="9EDX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.03 A"/>
        <property type="chains" value="A=37-345"/>
    </dbReference>
    <dbReference type="PDB" id="9EDY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=35-345"/>
    </dbReference>
    <dbReference type="PDBsum" id="6U69"/>
    <dbReference type="PDBsum" id="6U6A"/>
    <dbReference type="PDBsum" id="9EDV"/>
    <dbReference type="PDBsum" id="9EDW"/>
    <dbReference type="PDBsum" id="9EDX"/>
    <dbReference type="PDBsum" id="9EDY"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKB4"/>
    <dbReference type="SMR" id="A0A1D8PKB4"/>
    <dbReference type="FunCoup" id="A0A1D8PKB4">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKB4"/>
    <dbReference type="EnsemblFungi" id="C3_05650W_A-T">
        <property type="protein sequence ID" value="C3_05650W_A-T-p1"/>
        <property type="gene ID" value="C3_05650W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643655"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305650WA"/>
    <dbReference type="CGD" id="CAL0000192790">
        <property type="gene designation" value="YCK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05650W_A"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKB4"/>
    <dbReference type="OMA" id="DWMHLNG"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903338">
        <property type="term" value="P:regulation of cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010570">
        <property type="term" value="P:regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900190">
        <property type="term" value="P:regulation of single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000968">
        <property type="entry name" value="Casein kinase I, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000463442" description="Serine/threonine protein kinase YCK2">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18653474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19700637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="31924499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="19700637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="6U69"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="6U6A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="9EDV"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="9EDW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9EDX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="9EDY"/>
        </source>
    </evidence>
    <sequence length="495" mass="56461" checksum="B24670D652742CB8" modified="2017-01-18" version="1">MTTNPALAAAQASHNNIPTKQMNHSTSSSNGNGSNNSSVVGLHYKIGKKIGEGSFGVIFEGTNIINGVPVAIKFEPRKTEAPQLRDEYRTYKHLQGCDGIPNAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAIQMLTLVEEVHRHDLIYRDIKPDNFLIGRRGATDENNVHLIDFGMAKQYRDPRTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDLEALGHVFFYFLRGQLPWQGLKAPTNKQKYEKIGDKKRTTPAVTLCDGLPQQFAEYLDSVRSLPFDAEPPYEEYRMLLLSVLDDLGQACDGDMDWMHLNGGRGWDATINKKPNLHGYGHPNPPNERERRHRDQRRTRQHQQSQQVQQQQLQAQAQAQQLQQLQQAQQAQQQQQSQQHQPLSAAQLHQQKLQHLVNRPLPPIKQESQSAIQSGNGHHELLNNNLGDQHGGKHEGYSSRPDQYQQQQMVAEEEENKGFWSKLCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL40</accession>
    <name>A0A1D8PL40_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C400730CA</name>
        <name evidence="2" type="ordered locus">orf19.11645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Schwartz K."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Weissman J.S."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000182981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="394" mass="44809" checksum="DA5A3A66B43BCAE4" modified="2017-01-18" version="1">MHLLLRIPPRFGLSSWGSIRPILPRRIPNFPRFNSSTGSSLTIPTLSPSLLQRAQTIQQEHKELSEKLADKYIPDLQVKFDNYTNILSMFDKLETLTQEYIELTEITDDPDLYKEAQEELKSIVIPQIEKLVSELRVKLRPPVKYADKGCIIELRPGVGGNEASLFTGDLLNMYMNFASEMNWKYKIISEGKNSSGFINEAILSIDTLGSYDIMRHESGVHRVQRIPETETKGRVHTSTAAVVVLPKLSEGNESSLKDDERVFAPGEVRIDTMRAGGKGGQHVNTTDSAVRLLHIPTGMIVIQQDERSQPLNKAKAFAILRSRLAQKEQEEEMLKQKKLRTDQVSSTDRSDKIKTYNYKENRVTDHRINYSMHDLEGVLEGRKLGQLIDVYRSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM93</accession>
    <name>EDC3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EDC3</name>
        <name type="ordered locus">CAALFM_C405190CA</name>
        <name type="ordered locus">orf19.14148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Fungal Genet. Biol." volume="48" first="1116" last="1123">
            <title>Accumulation of P-bodies in Candida albicans under different stress and filamentous growth conditions.</title>
            <authorList>
                <person name="Jung J.H."/>
                <person name="Kim J."/>
            </authorList>
            <dbReference type="PubMed" id="22056521"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2011.10.003"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="FEBS J." volume="281" first="4841" last="4851">
            <title>Roles of Edc3 in the oxidative stress response and CaMCA1-encoded metacaspase expression in Candida albicans.</title>
            <authorList>
                <person name="Jung J.H."/>
                <person name="Kim J."/>
            </authorList>
            <dbReference type="PubMed" id="25158786"/>
            <dbReference type="DOI" id="10.1111/febs.13022"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="J. Microbiol." volume="53" first="111" last="115">
            <title>Deletion analysis of LSm, FDF, and YjeF domains of Candida albicans Edc3 in hyphal growth and oxidative-stress response.</title>
            <authorList>
                <person name="Kim E.C."/>
                <person name="Kim J."/>
            </authorList>
            <dbReference type="PubMed" id="25626365"/>
            <dbReference type="DOI" id="10.1007/s12275-015-4727-y"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="Fungal Genet. Biol." volume="97" first="18" last="23">
            <title>Mutational analysis of metacaspase CaMca1 and decapping activator Edc3 in the pathogenicity of Candida albicans.</title>
            <authorList>
                <person name="Jeong J.H."/>
                <person name="Lee S.E."/>
                <person name="Kim J."/>
            </authorList>
            <dbReference type="PubMed" id="27815149"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2016.10.007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5 6 7 8">Stimulates decapping of both stable and unstable mRNA during mRNA decay (By similarity). Does not affect nonsense-mediated mRNA decay (By similarity). Required for normal P-body assembly (PubMed:22056521). Plays critical roles in filamentous growth and stress-induced apoptotic cell death (PubMed:25158786, PubMed:25626365). Involved in the regulation of expression of the oxidative stress-related genes encoding CAT1, SOD1, and MCA1 (PubMed:25158786). Especially, plays a critical role in oxidative stress-induced cell death via the regulation of the stability or translation of the metacaspase MCA1 mRNA (PubMed:25158786). Required for the virulence in a murine model of systemic candidiasis (PubMed:27815149).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
        <text evidence="5">Localizes to P-bodies under glucose-deprivation conditions.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal Sm domain and the YjeF domain are critical in hyphal growth and oxidative stress response.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6 7 8">Greatly reduces the number of P-bodies (PubMed:22056521). Shows increased resistance to various stresses, including hydrogen peroxide, acetic acid, and high temperature (PubMed:25158786). Leads to lower reactive oxygen species (ROS) level following oxidative stress and decreased expression of the metacaspase gene MCA1 (PubMed:25158786, PubMed:25626365). Leads also to up-regulation of the expression of the catalase CAT1 and the superoxide dismutase SOD1 (PubMed:25158786). Entirely abolishes H(2)O(2)-induced increase of caspase activity (PubMed:27815149). Reduces virulence in a murine model of systemic candidiasis (PubMed:27815149).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712246.1">
        <property type="nucleotide sequence ID" value="XM_707153.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM93"/>
    <dbReference type="SMR" id="A0A1D8PM93"/>
    <dbReference type="FunCoup" id="A0A1D8PM93">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM93"/>
    <dbReference type="EnsemblFungi" id="C4_05190C_A-T">
        <property type="protein sequence ID" value="C4_05190C_A-T-p1"/>
        <property type="gene ID" value="C4_05190C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646152"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405190CA"/>
    <dbReference type="CGD" id="CAL0000174840">
        <property type="gene designation" value="EDC3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05190C_A"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM93"/>
    <dbReference type="OMA" id="AMFDKKS"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="PHI-base" id="PHI:6796"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000023">
        <property type="entry name" value="Enhancer of mRNA-decapping protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000463494" description="Enhancer of mRNA-decapping protein 3">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="4 7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="3">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="2 7">
        <location>
            <begin position="246"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P39998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22056521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="25158786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="25626365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="27815149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="22056521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="512" mass="57073" checksum="4F16D03861949A87" modified="2017-01-18" version="1">MTEFLNYKVDLTLKDGTKSTGLISQVDSQQIRLSNAIQSIQPKQTIPYLDIKSSEIADLKVIQLPPDFKQQQKKKQKPRNGELIDDAIVFASKPGTPRVHTPKLKTQKPHAVSAGSEQPDWDTSSDVQDIKSSNEFDFQANLAMFDKKSVFADFQKRDHTNIGDRLVGHNKIENVNKLKKEKYDNDEMVLDQNRTDNWDNIGTATTSKTGTPVVNQNGYKDSQHQHLKLINANNLGNVALASPVQMLEIERLATDSFGITQAMMAEVCATNLSQLIMESILGGASRLSNKKNHNLPPLVLLLIGSARGGSRAFATGRHLTNHGVRVLAFMINTVEVDADLQQQWKLFESSGGKVVISNIIELLDIINNQLDTPVEIIIDALQGYDDHLEDTFYQDEDQATLRKLMKWCNEPQQQNKIMSLDIPSGVDGGSGTLSDDSLKLNCRWCISMGIPLSGIILAYKNGNMSLRDGDIVHYLVDVGIPNKVYSSKGNLRKFDKFWYCSEASIKLEVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMY7</accession>
    <name>A0A1D8PMY7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C500600CA</name>
        <name evidence="2" type="ordered locus">orf19.8544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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                <person name="Dungan J."/>
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    <reference evidence="9 10" key="2">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Dungan J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710954.2">
        <property type="nucleotide sequence ID" value="XM_705862.2"/>
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    <dbReference type="SMR" id="A0A1D8PNU8"/>
    <dbReference type="STRING" id="237561.A0A1D8PNU8"/>
    <dbReference type="GeneID" id="3647443"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503970WA"/>
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    <dbReference type="eggNOG" id="KOG1515">
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        </source>
    </evidence>
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</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21465" checksum="37A36916A76EE2CE" modified="2017-01-18" version="1">MPTNQPTKFEVPVDLLTPESCISSSRIRAFLKRSRNLTDDTIRPHLNEIEKSKCSQYFEEEIVPQWRVRGEIIDYCSKYSQELRDHTSQGKTVTATKLSYDLPNAEEMTDKFDLRTDPYAYKSYQRRIDEQYAQCDALDNWTQNEKTVEQIIRQQTVEVLNDKCFYQDWMQAFKRASNPKK</sequence>
</entry>
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    <accession>A0A1D8PPV3</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712509.2">
        <property type="nucleotide sequence ID" value="XM_707416.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPV3"/>
    <dbReference type="SMR" id="A0A1D8PPV3"/>
    <dbReference type="GeneID" id="3645872"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602280WA"/>
    <dbReference type="CGD" id="CAL0000196675">
        <property type="gene designation" value="orf19.10973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02280W_A"/>
    <dbReference type="eggNOG" id="ENOG502S195">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPV3"/>
    <dbReference type="OMA" id="MNDYVTF"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000196675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="395" mass="41971" checksum="B6A1F667F425FECF" modified="2017-01-18" version="1">MSATIIDNGQPKAKTPLKKEELEQIARQLKKKLSKASITAKQSLSPTNIKTSTTIALPKSSPLKSYIMKNNSNDHSPTNNISNLSSSPINLYSPNGKSPTHIRTPAAAFLSCSPLKNVSHADTSADDMLDSPTKRRKTSPRKMVLQEITPEKVKKESTLKPSLELTSTPTKKKPESPSKDKTTTPTMAKRELSSQSSTSSSAQNALLKTPKQNSNGNGYNDAEGADLLMYLATSPSPARPYLSNTPRVMNKPLPSISQSSISQSSQPSQSQSQSQSQTSTTSASASASANASSSAGSGSAANASSSSSSSSFLAPPPPVTPKRVINSHSTRTPQNRLTPFFNTLNANGLPSQGLALTPTSFNMNDYVTFFTPSPGGAFNKNLLKTPDFHNSLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ51</accession>
    <name>A0A1D8PQ51_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C603290WA</name>
        <name evidence="6" type="ordered locus">orf19.13062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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        </source>
    </evidence>
    <sequence length="654" mass="76363" checksum="2AB1ACB146F724CC" modified="2017-01-18" version="1">MSSKSRSYVSIACDNCRKRRRKCNGELPCHYCSGKNKPCVYDKTKDKRRRRVDLVYVDYLEHKYNNLLNFVKRIRSTTKDERLRAQCNEMLANNDPKFIDNKDLGLSNDESTHNNQSDKQQKEIIQLDNPMDELVSMKWELKFDESGNTKFLGPPVRQVDRCLVKDSMVAMEDPERVSYFNETVLADTEFMKELINTFFQNLLPFNLVLEEINVDEITREITSMTGKRSCYEAVSCLHLLALAILAYGFSILPKDHPYFQNLNGWNPFLSIVERSLFKLLRKSSHTTTGNLIDHSHIVYTILIITILHLGNYDESQAWVYSSILCSQIQHVGWNVSTDYPSESNDLSKFRSKLFWNCLVVEKISASMFGRSSPINFRQLLTDFYTSETKDINELVFQFNSKLWFIYDKFMGQVYSFHFNTQNKMLYKKVLMTATQSFQDFQGFMNQYLPLNETNLDNQNIILLHLTFHVFLLLIIRPYMKMPEIAGSIFQKSISITEQCYILINQYNSKFGNGVTTGWYNCHYGFLLYQVSVFLLCAIPVHDSVGPPGQHNVLIQRLHLFLQCLKNGSKYLPVYNVYYQTLLNIFNNMTLDEEISILVRQAYENESIEVKTSSVEKEDLVLDFDQDWQSYVNSLNLELNQDVYSYLEEGILDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ82</accession>
    <name>A0A1D8PQ82_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">NOG2</name>
        <name evidence="13" type="ordered locus">CAALFM_C603640WA</name>
        <name evidence="12" type="ordered locus">orf19.13154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Nucleus</location>
            <location evidence="3 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331013.1">
        <property type="nucleotide sequence ID" value="XM_019475468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ82"/>
    <dbReference type="SMR" id="A0A1D8PQ82"/>
    <dbReference type="FunCoup" id="A0A1D8PQ82">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ82"/>
    <dbReference type="GeneID" id="3640299"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603640WA"/>
    <dbReference type="CGD" id="CAL0000182741">
        <property type="gene designation" value="NOG2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03640W_A"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ82"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000005">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="CP-type G" evidence="11">
        <location>
            <begin position="212"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000182741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW30293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="533" mass="61212" checksum="E52896409F38FA80" modified="2017-01-18" version="1">MGTQKKEKQRRVRENDTRDGNLRVKGENFYRDAKKVKHLNMYKQGRAIRNKKGEIIKAADLQSTDIPNARVDPNRKWFGNTRVIAQDALTHFREVMGEKSKDSYQVLLKRNKLPMSLLDEKDTTESPTAKIVETESYSSTFGPKQQRKKPRVAASSLEDLMNAAEADSTQFQEKQELDSTLGLMGGSILDKDDFTQEAKEAIFHKGQSKRIWNELYKVIDSSDVVIHVLDARDPVGTRCESVEKYIKDECPHKHLIYVLNKCDLVPTWVAAAWVKHLSKSFPTLAFHASITNSFGKGSLIQLLRQFSTLHSDRKQISVGFIGYPNTGKSSIINTLRKKKVCQVAPIPGETKVWQYITLMKRIFLIDCPGIVPPSSKDTESDILFRGVVRVEHVSNPEQYIPDMLQKCERKHLERTYEIKGWSKFEEDESLLERASTEFIELIARKQGRLLKGGEPDESGVSKQILNDFNRGKIPWFVPPPKDEEKDEDKTGEDKKIGYKRKRQEREAAEKELQEKEENQDEDDKEVKKAKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQP9</accession>
    <name>A0A1D8PQP9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C700920CA</name>
        <name evidence="1" type="ordered locus">orf19.7022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720316.1">
        <property type="nucleotide sequence ID" value="XM_715223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQP9"/>
    <dbReference type="SMR" id="A0A1D8PQP9"/>
    <dbReference type="GeneID" id="3637957"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700920CA"/>
    <dbReference type="CGD" id="CAL0000194521">
        <property type="gene designation" value="orf19.7022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00920C_A"/>
    <dbReference type="eggNOG" id="ENOG502RS0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQP9"/>
    <dbReference type="OMA" id="IDCKFIN"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000194521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="342" mass="38684" checksum="591A54E891BB657E" modified="2017-01-18" version="1">MSLTVRQPTEESYWNFKVNSQNNAISTMSIISQTDSLVVTNVNDDKLYSMDINDQFRVDRTIVTGVEIPDVSVVDTFEFNCIVAAKDVVSLIDLEIGEKNYEFYNTPKREERDMVRNAIIDCKFINNQLMATCGRNSRLNLFDIRLNNNNGPVSDIAFVNYVVGGDQNCIGYNGDYISVGNSLGQIYSLDLRNSRIIEDKVSNSSIISMQQSKDSCIFIDQIGDLKMYNITNGNYLLSQNVSGGEQLTKRGNIEYIKDHNKIITRSNTNDRQVQILSIGVNNDTNKSGNDLPYYCEQTTKTIEVDKSINEKSAINYTKYNSYSNRLIASDDKGTIHVWNNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQW4</accession>
    <name>A0A1D8PQW4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C701710WA</name>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRG9</accession>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_710138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRG9"/>
    <dbReference type="SMR" id="A0A1D8PRG9"/>
    <dbReference type="FunCoup" id="A0A1D8PRG9">
        <property type="interactions" value="922"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRG9"/>
    <dbReference type="GeneID" id="3643115"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703990CA"/>
    <dbReference type="CGD" id="CAL0000185454">
        <property type="gene designation" value="orf19.7182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03990C_A"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRG9"/>
    <dbReference type="OMA" id="MNEKACV"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="THUMP" evidence="4">
        <location>
            <begin position="133"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000185454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="268" mass="30924" checksum="44849A867BF8E925" modified="2017-01-18" version="1">MGKRKAADSNNPPKKKFKNVSKLLDPNTSGIYVSCARRKEANCRQELLNLLSEKVPEYFDLENVEDDEDETQIDKKELSIEDKIKQELQELEESKNSKKELLQPVDVDLECLVFIKTKKPIDPEVLVEKLCKECYESGQKTTRYTQKLVPIMDSCSSTGDDPLEKVRQLARKVLARHFHQEKDQKPVKFAVQVSRRNFNVLKSDVIIKTIAECVGNSHGHSVDLKNYDKLIIVECYKNNIGMGVANNFLKYSKYNLQQIFDKHQEDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRI1</accession>
    <name>A0A1D8PRI1_CANAL</name>
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        <submittedName>
            <fullName evidence="9">Type I HSP40 co-chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">HLJ1</name>
        <name evidence="9" type="ordered locus">CAALFM_C704050WA</name>
        <name evidence="8" type="ordered locus">orf19.7175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718215.2">
        <property type="nucleotide sequence ID" value="XM_713122.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS06"/>
    <dbReference type="STRING" id="237561.A0A1D8PS06"/>
    <dbReference type="GeneID" id="3640080"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01600CA"/>
    <dbReference type="CGD" id="CAL0000181162">
        <property type="gene designation" value="orf19.10081"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01600C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PS06"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000181162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="986" mass="113535" checksum="73A0649D469CF1B0" modified="2017-01-18" version="1">MLISLLRRQSNLNSFRSSYFSLLLRRSSSKSSTAFFHENPISRTDAITNNDFNPNLKFKHYYDSQNCFINPCSHYNKHTVARPKKIEQFYTPPQNFQDIIDQNENNIPVEGSFVEITRPDFKPRIGLVVRQALSRFDARYNKLQVLTSDNELIDVSASEVNFHLHQMIPHDFISCQQIVTSRHNKKCKERIRAIEFLDSFINDVVDLKTCMEPMFDRIYAQVSTNSISHVTLVDIIDAIKYQETLVIKIGSSFYNQCVLLFSIHWCLVSSPKWIVPNYFANNKLTNVLQGHSNNFHTRASYFVTPGNISVSISKFMRYMKNPDSHEIIEKFLAQLKTRNGDELSHFLQVYDGRHLAYILEVIKFAIVYPHDSIIKQLNKLASFKNCSTPNDLYNKLLDLNIYDKSTDVVLSSGIVGSSDRINVSSADQLQIENLWSGENGDLFRHLRTKKKYYRDHIIYGLPLDDNETCSRFAISLETINSRKYILNIHIPDITTVLPPGDFMMENMFDKFTELSNKFSNSFQSNLFSNRFEESKRFHKYETVDSENLWDDELLQNSKSQRNPSKVTCMTISFQFNSYEPEPFKYFENKISVSFDSISNLNVKILDKELLEKCLSGKLETSLFKLLRRNQTQGFSDRPHLNKGDIHNINYINGIMKTFFKMREHSGAAVIKPQQESLVSSSSNFLSKIGADKPRLYSHSDFILRELQIFTGALVAEYCTQHRIPAMFHCQDVEPTVYDSDKVMVTHDNIMIPPYDSENYHHSILAKDSDGYISLQASFVSKNYLSPENVIAGPGNNNLLLGLKNGYINIVDVFTKKEAIINQYQLLSYQQALFSRNLSMEKGYLKTVQQFNILKSLGYQLQGPLTESRLGSYIEACHQSHEISSFVGSILRKYVVLKWLEKAQIDINEGNGLEVFHCIVTLVGKKYDLGVVCKCFCMELGIEIDVLTENSDIHIGSKLVCDKVLQVNAIDRTCLLRDENYGSTWYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSC5</accession>
    <name>RL28_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPL28</name>
        <name type="ordered locus">CAALFM_CR03030CA</name>
        <name type="ordered locus">orf19.2864.1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331067.1">
        <property type="nucleotide sequence ID" value="XM_019475522.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="AB/BV=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="AB/BV=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="AB/BV=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="AB/BV=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="AB=1-149"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
    <dbReference type="PDBsum" id="7Q0R"/>
    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSC5"/>
    <dbReference type="EMDB" id="EMD-13737"/>
    <dbReference type="EMDB" id="EMD-13741"/>
    <dbReference type="EMDB" id="EMD-13744"/>
    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PSC5"/>
    <dbReference type="FunCoup" id="A0A1D8PSC5">
        <property type="interactions" value="1059"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSC5"/>
    <dbReference type="EnsemblFungi" id="CR_03030C_A-T">
        <property type="protein sequence ID" value="CR_03030C_A-T-p1"/>
        <property type="gene ID" value="CR_03030C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515386"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03030CA"/>
    <dbReference type="CGD" id="CAL0000198266">
        <property type="gene designation" value="RPL28"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03030C_A"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSC5"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456531" description="Large ribosomal subunit protein uL15">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="149" mass="16663" checksum="2529EC289950F73A" modified="2017-01-18" version="1">MPTRLTKTRKHRGNVSAGKGRIGKHRKHPGGRGKAGGQHHHRTNLDKYHPGYFGKVGMRYFHKQQNHFWRPEINLDKLWTLVDSEKKDEYLSKSSASAAPVIDTLAHGYGKVLGKGRLPEVPVIVKARFVSKLAEEKIRAVGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSU7</accession>
    <name>A0A1D8PSU7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR04850CA</name>
        <name evidence="1" type="ordered locus">orf19.13685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711093.2">
        <property type="nucleotide sequence ID" value="XM_706001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSU7"/>
    <dbReference type="GeneID" id="3647295"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04850CA"/>
    <dbReference type="CGD" id="CAL0000195505">
        <property type="gene designation" value="orf19.13685"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04850C_A"/>
    <dbReference type="eggNOG" id="ENOG502R6HI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSU7"/>
    <dbReference type="OrthoDB" id="4084239at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000195505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="258" mass="30277" checksum="CCE51AA8A9F51567" modified="2017-01-18" version="1">MQAFFLSFVIKNDNENQNDNENQNDNDKVPLLTNLKTLQLPDFFTSFIYYKPDFMESLLHTCKCWGCQLVLNKLEHEFYDKLIDENLETNYYMTIGYILGKLQADREVCIPIKEKTFHYNKYPINKGQPHTLHNNFHIPNENENENEEEVDNHSMMTNCCQCNIINDPLGVDELNIDNLVTTYIIHQVDPIINYLNVMFINLDNLMIHGIYYERDPLIGKMIPIYDNSEYPQSFLMGAKDYIERGLNPPGPFGTFRGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT03</accession>
    <name>YCP4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)H quinone oxidoreductase YCP4</fullName>
            <ecNumber evidence="10">1.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavodoxin-like protein YCP4</fullName>
            <shortName evidence="8">FLP YCP4</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YCP4</name>
        <name type="ordered locus">CAALFM_CR05380CA</name>
        <name type="ordered locus">orf19.5286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="J. Proteomics" volume="127" first="340" last="351">
            <title>Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host-pathogen interaction.</title>
            <authorList>
                <person name="Gil-Bona A."/>
                <person name="Parra-Giraldo C.M."/>
                <person name="Hernaez M.L."/>
                <person name="Reales-Calderon J.A."/>
                <person name="Solis N.V."/>
                <person name="Filler S.G."/>
                <person name="Monteoliva L."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="26087349"/>
            <dbReference type="DOI" id="10.1016/j.jprot.2015.06.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2015" name="PLoS Pathog." volume="11" first="e1005147" last="e1005147">
            <title>Flavodoxin-Like Proteins Protect Candida albicans from Oxidative Stress and Promote Virulence.</title>
            <authorList>
                <person name="Li L."/>
                <person name="Naseem S."/>
                <person name="Sharma S."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="26325183"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1005147"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence (PubMed:26087349, PubMed:26325183). FLPs act as NAD(P)H quinone oxidoreductases (PubMed:26325183). Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane (PubMed:26325183).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + NADPH + H(+) = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4">Expression is down-regulated during biofilm formation.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6">Increases the sensitivity to the oxidative stress agent H(2)O(2) (PubMed:26087349). Quadruple mutant lacking all four FLPs (PST1, PST2, PST3 and YCP4) is more sensitive to benzoquinone and linolenic acid, a polyunsaturated fatty acid that can auto-oxidize and promote lipid peroxidation (PubMed:26325183). The quadruple mutant is also avirulent in a mouse model of systemic candidiasis (PubMed:26325183).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="10"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710367.1">
        <property type="nucleotide sequence ID" value="XM_705275.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT03"/>
    <dbReference type="SMR" id="A0A1D8PT03"/>
    <dbReference type="FunCoup" id="A0A1D8PT03">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PT03"/>
    <dbReference type="EnsemblFungi" id="CR_05380C_A-T">
        <property type="protein sequence ID" value="CR_05380C_A-T-p1"/>
        <property type="gene ID" value="CR_05380C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3648032"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05380CA"/>
    <dbReference type="CGD" id="CAL0000193139">
        <property type="gene designation" value="YCP4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05380C_A"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT03"/>
    <dbReference type="OMA" id="HGMPYIP"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000459479" description="NAD(P)H quinone oxidoreductase YCP4">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="21414038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="26087349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="26325183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="26087349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="26325183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="26325183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="288" mass="29783" checksum="96E82E7C32F6343D" modified="2017-01-18" version="1">MKIAIIQYSTYGHITQLAKAVQKGVADAGYKADIFQVPETLPQEVLDKMHAPAKPTDIPIATNDTLTEYDAFLFGVPTRYGTAPAQFFEFWGATGGLWANGSLAGKPAGVFVSTSGQGGGQETTVRNFLNFLAHHGMPYIPLGYANAFALQSSMEEVHGGSPYGAGTFANVDGSRQPSTLELEIAEKQGEAFVKSATKLVKGSKKTNTTTTSKSAATSDAAGTTSGTAAGTSAATGAATGTSAPKESTKEASSSAKKEATNGTATRTQQSTKAPETAEKSSCSKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTF1</accession>
    <name>A0A1D8PTF1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emp46p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">EMP46</name>
        <name evidence="9" type="ordered locus">CAALFM_CR07180WA</name>
        <name evidence="8" type="ordered locus">orf19.8350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713090.2">
        <property type="nucleotide sequence ID" value="XM_707997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTF1"/>
    <dbReference type="SMR" id="A0A1D8PTF1"/>
    <dbReference type="FunCoup" id="A0A1D8PTF1">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTF1"/>
    <dbReference type="GeneID" id="3645270"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07180WA"/>
    <dbReference type="CGD" id="CAL0000179572">
        <property type="gene designation" value="EMP46"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07180W_A"/>
    <dbReference type="eggNOG" id="ENOG502RYE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTF1"/>
    <dbReference type="OMA" id="VMAYYTF"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000179572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="465" mass="53235" checksum="830B26CEBF7632C4" modified="2017-01-18" version="1">MLYHILLLIHVALAVVPNIPKISSQLSPNPHYSLPNLLSIESKEDINNFDISNNIQFDNGRLLLGELGSIWGKYKIPTLNKPWTIELIFRSTGTKEDRKYEDNSLNVWLLNEDNNNLPFDSFDGFEISINNEGQIPGVKLYNNDGSQNIIHDASHVLGTCKFQYLDSDVPFTLRISYDANSWFKIQLDNNLCFKTNQISIPFQELKLGITSKINQQSNEKFEILSLKTWELLTADAIDDHGLMIGDEIKIDVETEVKNDNQVKPNHIRESLMERAQRLRKEAIDSERQNLKNQDSNTNSQLDLILSKLNYLEVSLTGLNGGEDDSQILSINKEITGLNNVFAELKSTVTDTKQAVVDLQNVLVKQYSQMLDSIAQLNQKVIGEVREQHYGMEELSRKVDLLMNNHKEIAYQYEKTRQDTQGEASKSGNVIDKLLKWILFPLVLILLVLVIFVYRLRHDIKHSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTX1</accession>
    <name>A0A1D8PTX1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">ARP2</name>
        <name evidence="9" type="ordered locus">CAALFM_CR08950WA</name>
        <name evidence="8" type="ordered locus">orf19.7292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331112.1">
        <property type="nucleotide sequence ID" value="XM_019475567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTX1"/>
    <dbReference type="SMR" id="A0A1D8PTX1"/>
    <dbReference type="FunCoup" id="A0A1D8PTX1">
        <property type="interactions" value="1127"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTX1"/>
    <dbReference type="GeneID" id="3641915"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08950WA"/>
    <dbReference type="CGD" id="CAL0000193205">
        <property type="gene designation" value="ARP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08950W_A"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTX1"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052032">
        <property type="term" value="P:symbiont-mediated perturbation of host inflammatory response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000193205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="391" mass="44323" checksum="B92B7FF1CDF7B626" modified="2017-01-18" version="1">MSTPIVLDQGTGFVKIGRAGTNFPDHTFPSMVGRPILRAEERNILVPSDVEIKDIMCGSEASQVRSLLQINYPMENGIIKNWEDMEHLWDYAFYERMKINPQGQKILLTEPPMNPLKNREMMCQVMFEKYGFDGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTKRLDVAGRDVTRHLINLLFRRGYAFNRTADFETVRQIKEKLCYVSYDLGFDAKLARETTTLVESYELPDGRVIKVGSERFEAPECLFQPHLVDVEQPGVGETLFNTIQSADVDIRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLQGDASRLDKFKVRIEDPPRRKHMVFIGGAVLANIMADKDHMWISKQEWEEQGPRVLEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU82</accession>
    <name>A0A1D8PU82_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_CR10430CA</name>
        <name evidence="6" type="ordered locus">orf19.7620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719381.1">
        <property type="nucleotide sequence ID" value="XM_714288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU82"/>
    <dbReference type="STRING" id="237561.A0A1D8PU82"/>
    <dbReference type="GeneID" id="3638975"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10430CA"/>
    <dbReference type="CGD" id="CAL0000188698">
        <property type="gene designation" value="orf19.7620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10430C_A"/>
    <dbReference type="eggNOG" id="ENOG502S8BR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU82"/>
    <dbReference type="OMA" id="KTERNDM"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="5">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000188698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW31693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="192" mass="21888" checksum="50266774E8415A13" modified="2017-01-18" version="1">MSGIKISLKKKNPKLKKLIVNNSQQTDESSEQQKKLITSYSTEDKTTHKDETKPIIVLKQPCKSMLQKEIEIDEKPILPYGVTTFEKVETTKQSMIKKIESEDSDDDSSDDRKIPIDEFGAAFLRGLGWQEEEEKNKDDSKSTNTQNLSHRKHGITLGIGAKPIDEEIIQDLNSTEKGIPIIKRRKLNHINK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>P0CY35</accession>
    <accession>A0A1D8PI42</accession>
    <accession>P16017</accession>
    <accession>Q5A743</accession>
    <name>EF1A1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor 1-alpha 1</fullName>
            <shortName>EF-1-alpha 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TEF1</name>
        <name type="ordered locus">CAALFM_C208370CA</name>
        <name type="ORF">CaO19.12585</name>
        <name type="ORF">CaO19.5119</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Bacteriol." volume="172" first="2036" last="2045">
            <title>Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans.</title>
            <authorList>
                <person name="Sundstrom P."/>
                <person name="Smith D."/>
                <person name="Sypherd P.S."/>
            </authorList>
            <dbReference type="PubMed" id="2180914"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="M29934">
        <property type="protein sequence ID" value="AAA34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A35154">
        <property type="entry name" value="A35154"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710148.2">
        <property type="nucleotide sequence ID" value="XM_705056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CY35"/>
    <dbReference type="SMR" id="P0CY35"/>
    <dbReference type="BioGRID" id="1223851">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="FunCoup" id="P0CY35">
        <property type="interactions" value="1912"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P0CY35"/>
    <dbReference type="MoonProt" id="P0CY35"/>
    <dbReference type="EnsemblFungi" id="C2_08370C_A-T">
        <property type="protein sequence ID" value="C2_08370C_A-T-p1"/>
        <property type="gene ID" value="C2_08370C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3648254"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208370CA"/>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08370C_A"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="InParanoid" id="P0CY35"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="3969558at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000090956" description="Elongation factor 1-alpha 1">
        <location>
            <begin position="2"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="70"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N,N,N-trimethylglycine" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine" evidence="2">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="458" mass="50012" checksum="C737C498FE923B09" modified="2011-10-19" version="1">MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYHVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAVNKMDSVKWDKNRFEEIIKETSNFVKKVGYNPKTVPFVPISGWNGDNMIEPSTNCPWYKGWEKETKSGKVTGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPAGVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKNDPPKGCDSFNAQVIVLNHPGQISAGYSPVLDCHTAHIACKFDTLVEKIDRRTGKKLEENPKFVKSGDAAIVKMVPTKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKSDKAGKVTKAAQKAAKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KI4</accession>
    <accession>A0A1D8PSU8</accession>
    <name>INO80_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">INO80</name>
        <name type="ordered locus">CAALFM_CR04720CA</name>
        <name type="ORF">CaO19.1734</name>
        <name type="ORF">CaO19.9302</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710254.2">
        <property type="nucleotide sequence ID" value="XM_705162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KI4"/>
    <dbReference type="SMR" id="Q59KI4"/>
    <dbReference type="FunCoup" id="Q59KI4">
        <property type="interactions" value="1151"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59KI4"/>
    <dbReference type="EnsemblFungi" id="CR_04720C_A-T">
        <property type="protein sequence ID" value="CR_04720C_A-T-p1"/>
        <property type="gene ID" value="CR_04720C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3648140"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04720CA"/>
    <dbReference type="CGD" id="CAL0000196418">
        <property type="gene designation" value="INO80"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04720C_A"/>
    <dbReference type="eggNOG" id="KOG0388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_26_2_1"/>
    <dbReference type="InParanoid" id="Q59KI4"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="PHI-base" id="PHI:123148"/>
    <dbReference type="PRO" id="PR:Q59KI4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900430">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003822">
        <property type="entry name" value="Chromatin-remodeling ATPase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000074320" description="Chromatin-remodeling ATPase INO80">
        <location>
            <begin position="1"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="DBINO" evidence="6">
        <location>
            <begin position="438"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="684"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1240"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="480"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAQ box">
        <location>
            <begin position="807"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="697"/>
            <end position="704"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9ULG1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="1387" mass="158823" checksum="68C05F806CF7E43A" modified="2017-03-15" version="2">MNISSMLSSDNNVSLKESMTTATDQQQQQQAESVDHASINGNGQTSVSAVNNVQENHLSEFHSSNQQHSSIPPVGTTVEHATTTTTTATNHQPVNSSPLKHSVDENSNPTTISSLKKDTNSIIASILPESYQFDNSYTPTIDQKYKSVFESNINVINQLDQYQQMGHHLKLMKFDEVKLNNYLINTGQFASNYIDRVVAEDISSRNNKISETNKNKELIAIDYSKPLHHNSTRGKEFKWGSTRKIHKVEHKSRRRKPAATTSTTDDSNKAVAAAANGTKDHSATAGTTASANGSDTPDRRHQRQSSKPSTPILIKPKTEPGKGSPEIQPRRSSRPKVKRKAFEDELETADKQSSTQQVKKSQESTGRDHKRVKIENKQEEQQQHQQQQQADEEDEAEAEAEAEQKPKSGALSEAAAAGMTAKEFKAFMRQYDNTYIAIWKDLSRKDGPKGSRSMQQATQGRLINLRKTALLAAREAKRWQLKNTKNQKDLTTKARRAMREMFNFWKRNERLERDLKKKHEKELLDKAKKEEEEREAKRQSRKLNFLITQTELYSHFIGKKIKTDELEGTNADDNLKSNTKEHLDKYADVDGSATHDINAVDFDNDDEEALRRMAAQNAQNALIEVQNKAKQFDNSEESFKNPDTNGEEMNFQNPTLLGDITIPQPNMLKCTLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVLAYLAETYNMWGPFLVVTPASTLHNWQQEITKFVPEFKVLPYWGNAKDRKILRKFWDRKSLRYDKDSPFHVLVTSYQLIVADIAYFQKMKWQYMILDEAQAIKSSSSSRWKSLLNLTCRNRLLLTGTPIQNSMQELWALLHFIMPSIFDSHDEFSDWFAKDIESHAQSNTSLDEQQLRRLHMILKPFMLRRIKKNVQSELGDKVEIDVYCDLTTRQKKLYQQLRSQISMSDTDLLELESNSTSSDSSLANLVMQFRKVCNHPDLFERADVNSPFSFGKFAETGSFLRETNELDVNYSTENIVQYDLPRLIYDELLTPNYNKSIRDSIYSKFSIYNPENMNATGWLQGINVSPNELKHYSQMDILSRAIEMQNKPTETEKLERINYLYEGDYIPKNKKLLITDHSTSTNSSFISNSLVFSDLVSIKEKVGEDMYLNKLEPAVTPIASAPPITVNCSSMNFTNKMNNTLFDSNIRSSLIPLSLSTELKLMKDQIPLEQYPKSNMLPMPIFDYSNIRMPSMDRFIAESGKLAKLDELLIDLKRGGHRILIYFQMTRMMQIFEEYLAYKSYKYIRLDGSTTIESRREMVQAWQTNPEIFIFMLSTRAGGLGLNLTSADTVIFYDSDWNPTIDSQAMDRAHRIGQTKQVKVFRLVTRNTIEQKILERAKEKEEIQKLVVGNM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LX9</accession>
    <accession>A0A1D8PDG8</accession>
    <accession>Q59LY9</accession>
    <name>BTN1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein BTN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BTN1</name>
        <name type="ordered locus">CAALFM_C105120WA</name>
        <name type="ORF">CaO19.11541</name>
        <name type="ORF">CaO19.4059</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710728.2">
        <property type="nucleotide sequence ID" value="XM_705636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LX9"/>
    <dbReference type="SMR" id="Q59LX9"/>
    <dbReference type="FunCoup" id="Q59LX9">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LX9"/>
    <dbReference type="TCDB" id="2.A.57.5.3">
        <property type="family name" value="the equilibrative nucleoside transporter (ent) family"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_05120W_A-T">
        <property type="protein sequence ID" value="C1_05120W_A-T-p1"/>
        <property type="gene ID" value="C1_05120W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647667"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105120WA"/>
    <dbReference type="CGD" id="CAL0000190783">
        <property type="gene designation" value="orf19.11541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05120W_A"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="InParanoid" id="Q59LX9"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="PRO" id="PR:Q59LX9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000256257" description="Protein BTN1">
        <location>
            <begin position="33"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="426" mass="48162" checksum="428F8D304F0CC9BF" modified="2017-03-15" version="2" precursor="true">MFIISETQRTFASFFIFGLLNNILYVIILSAAIDLVGPSTPKAIVLLADIIPSFSFKVAAPFFIHAVPYIIRLWTLVALSATGMVLISLSPTNVISWKILGITLASLSSGLGEVSFLQLTHYYEENSAIGGFSSGTGGAGLFGSFLFMVLTNVMGFPVWVVLLICAVFPSGFIITYFNLLPLPMHEYQVILQQQQEREEEQEEEEYQQQLQDEARSQNIESIREVKYSVNYISKHVQNTIHKITPLILPYMLPLTTVYISEYVINQGISPTLLFPLKEVPRWLISSYRDIYVVYGFLYQLGVFISRSSVTMGIRIKRLYLLSVLQFINVMITLYQSIYDLPFHSIWWLFLLIFYEGLLGGASYVNTFKSVSEQVSRTKREFSMGCVSISDSLGIVTAGCINWWLELKLCHLQVARGRDWCLKGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MZ8</accession>
    <name>Q59MZ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">RPB8</name>
        <name evidence="6" type="ordered locus">CAALFM_CR04780WA</name>
        <name evidence="5" type="ordered locus">orf19.13691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711099.1">
        <property type="nucleotide sequence ID" value="XM_706007.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MZ8"/>
    <dbReference type="SMR" id="Q59MZ8"/>
    <dbReference type="FunCoup" id="Q59MZ8">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MZ8"/>
    <dbReference type="GeneID" id="3647301"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04780WA"/>
    <dbReference type="CGD" id="CAL0000181508">
        <property type="gene designation" value="RPB8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04780W_A"/>
    <dbReference type="eggNOG" id="KOG3400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103864_1_0_1"/>
    <dbReference type="InParanoid" id="Q59MZ8"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000181508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="148" mass="16781" checksum="952FCF20CC0DE317" modified="2005-04-26" version="1">MSGILFEDMFIVDSTDPGRYNKVCRITGHSSTSKDITITLDINKELFPVQNHDSLTITLASSLGNESSMITSNGSWRPPKPDERSLADDYDYVMYGTVYKFEENADNDKMAVYISFGGLLMRLEGGYRSLSNLKQENAYILIRHYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q59N42</accession>
    <name>Q59N42_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">GLC7</name>
        <name evidence="12" type="ordered locus">CAALFM_CR07650WA</name>
        <name evidence="11" type="ordered locus">orf19.13664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711142.1">
        <property type="nucleotide sequence ID" value="XM_706050.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59N42"/>
    <dbReference type="SMR" id="Q59N42"/>
    <dbReference type="FunCoup" id="Q59N42">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59N42"/>
    <dbReference type="GeneID" id="3647257"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07650WA"/>
    <dbReference type="CGD" id="CAL0000191628">
        <property type="gene designation" value="GLC7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07650W_A"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="InParanoid" id="Q59N42"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000370">
        <property type="term" value="P:positive regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007116">
        <property type="term" value="P:regulation of cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901901">
        <property type="term" value="P:regulation of protein localization to cell division site involved in cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000191628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="330" mass="37824" checksum="D7D103C0860CE8C9" modified="2005-04-26" version="1">MSNNIEDDSISVDNIVDRLLEVRGSRPGKQVTLTENEIRFLCTKAREIFIQQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPADKKPRYAPANVANNRPGANQRKPKKAVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-10-29" modified="2025-02-05" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PE4</accession>
    <accession>A0A1D8PFG9</accession>
    <name>RV162_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RVS161-like protein RVS162</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RVS162</name>
        <name type="ordered locus">CAALFM_C112730WA</name>
        <name type="ORF">CaO19.6349</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Infect. Immun." volume="77" first="4150" last="4160">
            <title>BAR domain proteins Rvs161 and Rvs167 contribute to Candida albicans endocytosis, morphogenesis, and virulence.</title>
            <authorList>
                <person name="Douglas L.M."/>
                <person name="Martin S.W."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="19596778"/>
            <dbReference type="DOI" id="10.1128/IAI.00683-09"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of a cytoskeletal structure that is required for membrane curvature.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Does not display the endocytic, hyphal growth, virulence, or cell wall defects exhibited by disruption in related RVS161 or RVS167.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711567.2">
        <property type="nucleotide sequence ID" value="XM_706475.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PE4"/>
    <dbReference type="SMR" id="Q59PE4"/>
    <dbReference type="STRING" id="237561.Q59PE4"/>
    <dbReference type="EnsemblFungi" id="C1_12730W_A-T">
        <property type="protein sequence ID" value="C1_12730W_A-T-p1"/>
        <property type="gene ID" value="C1_12730W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646820"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112730WA"/>
    <dbReference type="CGD" id="CAL0000191779">
        <property type="gene designation" value="RVS162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12730W_A"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="InParanoid" id="Q59PE4"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000430557" description="RVS161-like protein RVS162">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P25343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19596778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="19596778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="335" mass="39383" checksum="A44FCFBA8110F0BD" modified="2017-03-15" version="2">MSWIGIKKAINRAGTQVMLKTGHIEQTIDKEYEFQEKRYRTMEENSIKLQKNLRLYLDSLRLLTNSQINIAESLNSFYGTNNDKRSSNISRTGSVNTGDKIQTIHEEEGEEKEEEENDNTTTTTTTTTTTITTTNTTYNYNNLIQEYYATIKQLNDSCIANLENPYNQTVLNPIARFNSYYIEINEIIKKRHNKLLDYDAMKNKLRKLIENPTTNISPSMKTNIIELNHNQYEEKLKIYNQELTEVESKYVEINNQLLIELPKLINHRISYFDPSFESFVKIQLRFFNENYHVLNQLQLKLDAQTRQDYIEGKLEDRIDDVLRKMKKLDITSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PW4</accession>
    <name>Q59PW4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C107650WA</name>
        <name evidence="1" type="ordered locus">orf19.10295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711721.1">
        <property type="nucleotide sequence ID" value="XM_706629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PW4"/>
    <dbReference type="GeneID" id="3646657"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107650WA"/>
    <dbReference type="CGD" id="CAL0000183823">
        <property type="gene designation" value="orf19.10295"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07650W_A"/>
    <dbReference type="HOGENOM" id="CLU_1570414_0_0_1"/>
    <dbReference type="InParanoid" id="Q59PW4"/>
    <dbReference type="OrthoDB" id="10295318at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000183823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW26412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="170" mass="18642" checksum="9C70982509EDE702" modified="2005-04-26" version="1">MSAMLPTIAPHFTVSSPSSVASANGTTNETVVIPRPDLTDNTVTSAPSTVASSTSHLATNIMSQPQSSTFTLSDAPASKLVTIRKRLQDLDQKLAPKSVKLTDIARIHKHLAVIHDPNSKIKQLYGKYYDLLWSISASERSKEEKNALKQFEIGSLPSYRTIDSRISFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PZ6</accession>
    <name>Q59PZ6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconolactonase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">SOL3</name>
        <name evidence="10" type="ordered locus">CAALFM_CR06700CA</name>
        <name evidence="9" type="ordered locus">orf19.8323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711777.1">
        <property type="nucleotide sequence ID" value="XM_706685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PZ6"/>
    <dbReference type="SMR" id="Q59PZ6"/>
    <dbReference type="FunCoup" id="Q59PZ6">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PZ6"/>
    <dbReference type="GeneID" id="3646625"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06700CA"/>
    <dbReference type="CGD" id="CAL0000186724">
        <property type="gene designation" value="SOL3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06700C_A"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="Q59PZ6"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF24">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000186724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="259" mass="28484" checksum="F96E3DE6AD97A097" modified="2005-04-26" version="1">MSTKVYSYSDSQDVANSVGKYVIEQQNKAIEANGSFKIALSGGSLGKILKQALIDNKEIGSKAQWDKWEVYFSDERLVPLYHPDSNFGLFNEMVLKNLPQETTNMKLHVIDQSLLTGKDGKLDDLVDQAKDQEIAKEYANGLPKQFDLILLGCGPDGHTCSLFPGHKLLEERDELISYISDSPKPPPRRITFTFPVLENAKAIAFVATGAGKAPVLREIFSGQSKLPCALVNDIKTGVSVSWFVDSPAVEGVDVLTSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SI3</accession>
    <name>Q59SI3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C400530CA</name>
        <name evidence="7" type="ordered locus">orf19.11666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712643.1">
        <property type="nucleotide sequence ID" value="XM_707550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SI3"/>
    <dbReference type="STRING" id="237561.Q59SI3"/>
    <dbReference type="GeneID" id="3645746"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400530CA"/>
    <dbReference type="CGD" id="CAL0000175833">
        <property type="gene designation" value="orf19.11666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00530C_A"/>
    <dbReference type="eggNOG" id="ENOG502RPXW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053735_0_0_1"/>
    <dbReference type="InParanoid" id="Q59SI3"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012633058" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000175833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="358" mass="41137" checksum="BFE63786D0DCB943" modified="2005-04-26" version="1">MRLILLLFISTTVTSLNILITTTDSWVSKNTRLLYSSLKEKHNVKLIAPLYQYNLEKNNIPLFSNKLAKDGGEYGHLLSVHQTYFHNLRSINSKRAKGVKFEQDESQSESESSTQDIVQSNQFGQDPLDKNCWYVDSNPFNSLQIGLDVILPNYYPDFKPDLTIIGPNEGLQNQQIINKMIHSTITNNNISTIAFSTEDEHHIYYQDENYFHISSNSIHQLMKHNVFTKNIKFINKEIGRIIDNLSNKGVIGLDFKFPSFNHFNSHCITSNSLQLKMQEFFSTLNIPNTKFNFKTEREGQTIKIVDVEHIQGEAGPEIVDMFTSKKQQLLKRMTNLDVDKGLINCNLIANVLYGETNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VH5</accession>
    <name>Q59VH5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C104840CA</name>
        <name evidence="11" type="ordered locus">orf19.8378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713568.1">
        <property type="nucleotide sequence ID" value="XM_708475.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VH5"/>
    <dbReference type="SMR" id="Q59VH5"/>
    <dbReference type="STRING" id="237561.Q59VH5"/>
    <dbReference type="GeneID" id="3644785"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104840CA"/>
    <dbReference type="CGD" id="CAL0000180993">
        <property type="gene designation" value="orf19.8378"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04840C_A"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2014932_0_0_1"/>
    <dbReference type="InParanoid" id="Q59VH5"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000180993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="123" mass="14005" checksum="0B959B6BEC7E5C0D" modified="2005-04-26" version="1">MGKYSTVPKFRGRKLTLTYENGSYCDIIDKNTNQRLRKSTILTFTCDREMSARASVSYIGQANECTYFFEVRSHHACPTAAKANNLAAVWIFLFIFLAAVFVYFSGGLLYRQMKQASTTRSKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2025-06-18" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Y37</accession>
    <name>PST2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)H quinone oxidoreductase PST2</fullName>
            <ecNumber evidence="7">1.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flavodoxin-like protein PST2</fullName>
            <shortName evidence="5">FLP PST2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PST2</name>
        <name type="ordered locus">CAALFM_C208640CA</name>
        <name type="ordered locus">orf19.11095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Antimicrob. Agents Chemother." volume="48" first="3064" last="3079">
            <title>Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.</title>
            <authorList>
                <person name="Karababa M."/>
                <person name="Coste A.T."/>
                <person name="Rognon B."/>
                <person name="Bille J."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="15273122"/>
            <dbReference type="DOI" id="10.1128/AAC.48.8.3064-3079.2004"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Free Radic. Biol. Med." volume="40" first="1201" last="1209">
            <title>Cap1p is involved in multiple pathways of oxidative stress response in Candida albicans.</title>
            <authorList>
                <person name="Wang Y."/>
                <person name="Cao Y.Y."/>
                <person name="Jia X.M."/>
                <person name="Cao Y.B."/>
                <person name="Gao P.H."/>
                <person name="Fu X.P."/>
                <person name="Ying K."/>
                <person name="Chen W.S."/>
                <person name="Jiang Y.Y."/>
            </authorList>
            <dbReference type="PubMed" id="16545688"/>
            <dbReference type="DOI" id="10.1016/j.freeradbiomed.2005.11.019"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="PLoS Pathog." volume="11" first="e1005147" last="e1005147">
            <title>Flavodoxin-Like Proteins Protect Candida albicans from Oxidative Stress and Promote Virulence.</title>
            <authorList>
                <person name="Li L."/>
                <person name="Naseem S."/>
                <person name="Sharma S."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="26325183"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1005147"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence (PubMed:26325183). FLPs act as NAD(P)H quinone oxidoreductases (PubMed:26325183). Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane (PubMed:26325183).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + NADPH + H(+) = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Expression is induced in the presence of benomyl (PubMed:15273122). Expression is up-regulated by oxidative stress via CAP1 (PubMed:16545688).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Quadruple mutant lacking all four FLPs (PST1, PST2, PST3 and YCP4) is more sensitive to benzoquinone and linolenic acid, a polyunsaturated fatty acid that can auto-oxidize and promote lipid peroxidation (PubMed:26325183). The quadruple mutant is also avirulent in a mouse model of systemic candidiasis (PubMed:26325183).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714456.1">
        <property type="nucleotide sequence ID" value="XM_709363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Y37"/>
    <dbReference type="SMR" id="Q59Y37"/>
    <dbReference type="STRING" id="237561.Q59Y37"/>
    <dbReference type="EnsemblFungi" id="C2_08640C_A-T">
        <property type="protein sequence ID" value="C2_08640C_A-T-p1"/>
        <property type="gene ID" value="C2_08640C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643909"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208640CA"/>
    <dbReference type="CGD" id="CAL0000176544">
        <property type="gene designation" value="PST2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08640C_A"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="InParanoid" id="Q59Y37"/>
    <dbReference type="OMA" id="GMFELEQ"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="PHI-base" id="PHI:5051"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050625">
        <property type="term" value="F:2-hydroxy-1,4-benzoquinone reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000459477" description="NAD(P)H quinone oxidoreductase PST2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15273122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16545688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26325183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="26325183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="26325183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="201" mass="21728" checksum="1FD5872BC287E2D5" modified="2005-04-26" version="1">MSKPRVAIIIYSLYHHVYTLAESAKIGIEAAGVKPDLFQVPETLTPEILKLVKAPPKPDIPIAEPKILNNYDAFLFGIPTRFGNMPAQWKGFWDGTGGQWARGDLRGKYAGVFVSTGTPGGGQETTVINTLSTLAHHGIVYVPFGYGSPRLADLNEVHGGSPWGAGTFAGADGSREVTELEKSIAQQQGEDFIKTITQFKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-06-18" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZV5</accession>
    <accession>A0A1D8PFX0</accession>
    <name>EIF3G_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="1">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="1">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="1">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIF35</name>
        <name type="ordered locus">CAALFM_C114260CA</name>
        <name type="ORF">CaO19.7236</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715036.1">
        <property type="nucleotide sequence ID" value="XM_709943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZV5"/>
    <dbReference type="SMR" id="Q59ZV5"/>
    <dbReference type="FunCoup" id="Q59ZV5">
        <property type="interactions" value="1143"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZV5"/>
    <dbReference type="EnsemblFungi" id="C1_14260C_A-T">
        <property type="protein sequence ID" value="C1_14260C_A-T-p1"/>
        <property type="gene ID" value="C1_14260C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643308"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114260CA"/>
    <dbReference type="CGD" id="CAL0000193017">
        <property type="gene designation" value="TIF35"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14260C_A"/>
    <dbReference type="eggNOG" id="KOG0122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="InParanoid" id="Q59ZV5"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000365438" description="Eukaryotic translation initiation factor 3 subunit G">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="197"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="279" mass="30686" checksum="F97523CF62BE468E" modified="2005-04-26" version="1">MSTGLLDSWADAGDEFSAPPEVIANPDGTKTVITFRTNQDGKKVKITQKIKEVKVQEKVHPLIAQRKNWKKYGKEKNSPPGPDTSTTQLGEKVDLKLGTSWKQDEKKEEEDKAHERAQKIAVQTIKCRVCGGDHYTAKCPFKDTLGAAAGVTPSGTTPEPTSEGGAGAAGAGKYVPRHLRADANGNVPTREARDDSTTLKVSQLNSFVDEDMLRNELFAKFGPLQRVTIVRNRETGESRGFAYVSFATEEIAQRALDTFNGKGYHSLILHLEWSKKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A431</accession>
    <name>Q5A431_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SelT/selW/selH selenoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C405890WA</name>
        <name evidence="2" type="ordered locus">orf19.8863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_711491.1"/>
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    <dbReference type="GeneID" id="3641795"/>
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        <property type="gene designation" value="orf19.8863"/>
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    <dbReference type="eggNOG" id="ENOG502S6UH">
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29319.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19780" checksum="5B91D0D9DBBED585" modified="2005-04-26" version="1">MSDPTQSSTPSSSINLNINKYPRIIIQYCHQCKWQNRAIWYLQEFLQTFASSSTSEIKIYDISIQPIFDFPGVFQIILQKESTNNKMETKIIYRRKFKNEEKYHNENQGDFVFDGFPDSKFLKKLIKMELGPELSIGHHLEKYSDDNKLYDGNNNDKNDDCKDCKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="165" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5R4</accession>
    <name>Q5A5R4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">SGS1</name>
        <name evidence="18" type="ordered locus">CAALFM_C210570WA</name>
        <name evidence="17" type="ordered locus">orf19.12795</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717138.1">
        <property type="nucleotide sequence ID" value="XM_712045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5R4"/>
    <dbReference type="SMR" id="Q5A5R4"/>
    <dbReference type="FunCoup" id="Q5A5R4">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A5R4"/>
    <dbReference type="GeneID" id="3641258"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210570WA"/>
    <dbReference type="CGD" id="CAL0000185821">
        <property type="gene designation" value="SGS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10570W_A"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_22_0_1"/>
    <dbReference type="InParanoid" id="Q5A5R4"/>
    <dbReference type="OMA" id="YQIMKGG"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:meiotic chromosome segregation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090399">
        <property type="term" value="P:replicative senescence"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:telomeric 3' overhang formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HRDC_dom"/>
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        <property type="entry name" value="HRDC_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
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    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="474"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="676"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1140"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000185821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW28025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1189" mass="134112" checksum="CA4BCF083BEE4C70" modified="2005-04-26" version="1">MINNLQEQVAWVKRTNPHITPQAVIDLIRKPFPKDKSAPIPQVPDSIPSSDKENIPISKSQRKVQSRLPLKTISANESTLQSTPTPVNKTRLPPETSDIIDLTHSPPKKRSPPQPSSPIQPTPKKQKLDDSVFRKLLGLHESKIKILEEKFLTSESTSISLDQKKELYKKLERQIELLDNEINALKSGLDDSTELSSSPDSPEFRVPITRPVRLEAARTIVESTENEEDDTEDHFGDQTMDGLLTPTQERMSQDDLNEMASFIDDRTFDITSQSSDGEFIAVESDTEINDIRLSPETATKYGIKYNSQVIGKARTEVSSPISRVPAIPEIDSSDSEPELPPIEEDEIEETTIPNLQSGPDSPIVIDDDDDDFLDFTTQLNKEREIDFIELDSDDDVQEEQWPKESNAPPAPAPTNPVLTIDSDDAFSDDDEDLKEYFTENRASKGSEPFMDEVHSILNNVFKLKSFRANQLEAVSATLSNKDVFVLMPTGGGKSLCYQLPALVKSGATKGTTVVISPLISLMQDQVQHLLAKNIKAGMFSSKGGNDDNKHTIHLFREGFLDIVYLSPERANKSNAMQTIMTKLYNNNQLARVVIDEAHCLSSWGHDFRPDYQGLGFFKDKFPKVPIMALTATANEKVQMDILHNLKMKDPVLLKQSFNRTNLFYEIKLKKSNCLLEIKDYILSRFSGKSGIIYCHSKQSCEHTSMKLNEYGLKTSFYHAGMSADKRFNIQKRWQENKIQVICATIAFGMGIDKPDVRFVIHLYLPRTLEGYYQETGRAGRDGNFSECVMYYCYKDARSLQNLIQRDEELSESGRESHLAKLRQVIQYCENTTDCRRKQVLQYFNETFDPANCHKQCDNCRDYNHVTSVEKDCTEYAKDIIKLVKSIQDEQVTVLYCQDVFRGLSHKKITEAGHHENEYHGKGQSLDKNDVERIFFYLLSQQCIVEYHVMHGGFATDYVKVGKNADVVLNGQKKIIISFSSRPGSASNSLGRTAANTGKPVEYQESFITARQMTTVDVPDSSFSQRCLQELREAREKASTECSISNSQIVGEVTLRDMSAKLPTNKKDFAKLEGIKKGQLEHFTHFKKILTSLAREKKKMANTSISTVVSDISSISTSTVSPYFQPSQQDQEILDTLRAASQPKPSKSSTQSSYTKKKGSKKFNKGRSGNYFKKAAPKSLANSHRNVMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5S5</accession>
    <name>Q5A5S5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">KIN3</name>
        <name evidence="13" type="ordered locus">CAALFM_C210530CA</name>
        <name evidence="12" type="ordered locus">orf19.12785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717128.1">
        <property type="nucleotide sequence ID" value="XM_712035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5S5"/>
    <dbReference type="SMR" id="Q5A5S5"/>
    <dbReference type="FunCoup" id="Q5A5S5">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A5S5"/>
    <dbReference type="GeneID" id="3641199"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210530CA"/>
    <dbReference type="CGD" id="CAL0000189018">
        <property type="gene designation" value="KIN3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10530C_A"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q5A5S5"/>
    <dbReference type="OMA" id="LALHRCH"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000917">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000189018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="428" mass="50721" checksum="086B941BB809859B" modified="2005-04-26" version="1">MSIIDEYESLEVIGKGSFGTVRRVRHKDGQILVRKEIEYTSMTSQERNHIISELRILRELDHPHIVKYYRHDHIPEKKMIHIYMEYCEGGDLAKVIKNFRASKSRIPEEFVWQVLVQVLLALYRCHYGVDAEKVNLFKTASEPKYANSIIHRDIKPDNIFVGSCIKLGDFGLAKMLSANDFAKTYVGTPYYMSPEVLLDDPYSPVCDIWSLGCVLYELCTLEPPFKAKSHLQLQAKIKRGVIEEVPDFYSSQLRTLIRSCITVDPEERPTCFDLIDSLAVRFLRKEMELKEMNENLEEYKKQLLKRSKELKETSKELDEYKQELVRKSEELSKREKYLDEEFELRKQAIELESKEIRMEYQREFNLVVEQEVKRRLEQRKPHGPRPLEDVSPRSPLKERNRPRVTDALERLHLEKRHTPEFEYISKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5V8</accession>
    <name>Q5A5V8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C404160WA</name>
        <name evidence="6" type="ordered locus">orf19.12751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717097.1">
        <property type="nucleotide sequence ID" value="XM_712004.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5V8"/>
    <dbReference type="SMR" id="Q5A5V8"/>
    <dbReference type="STRING" id="237561.Q5A5V8"/>
    <dbReference type="GeneID" id="3641185"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404160WA"/>
    <dbReference type="CGD" id="CAL0000174198">
        <property type="gene designation" value="orf19.12751"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04160W_A"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A5V8"/>
    <dbReference type="OMA" id="RAESHNA"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="316"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000174198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="507" mass="57817" checksum="FE05ADEFCC84E72B" modified="2005-04-26" version="1">MIRLIRQSSIQKFVRPQPQSQLLLRFNSQKINFHKPDKAYSNERSDAADAAATILSELHDEKVHPNKATWLDALKQREKFQAEGKTLDSYSYIDPITTAVGEKTRSDSFSYLILPFKDDKWLCDAYINAFGRLRVGQLFQDLDALAGRIAYRHCSPAEPVNVTASVDRIYMIKKVDEITNYNFVLAGSVTWTGRSSMEITVKGYAFEEEEITHIENEESLSEENVFLSANFTFVARNPLTHKSFAINRLLPVNENDWIDYRRAESHNAKKKLMAKNLSLIEPTPEESKLIYDMWKSSKSLQNDVEKKLNDGIAFMKDTVMKSTLFMQPQYRNRHSYMIFGGYLLRQTFELAYCTAATFSSAGPRFVSLDSTTFKNPVPVGSVLTMNSSISYTEHLHDSDQIKEEIDNDSPFNFSLPPTNKISKSPNAFLSEPGTLIQVKVDTYIQQLEQNDKKPAGTFIYSFFVPKEGNSSFCSVIPQTYSEMMTYIGGRRRAQDTAQYVETLPTSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A660</accession>
    <accession>A0A1D8PM36</accession>
    <name>PXR1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>PinX1-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PXR1</name>
        <name type="ordered locus">CAALFM_C404520WA</name>
        <name type="ORF">CaO19.11312</name>
        <name type="ORF">CaO19.3831</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PINX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717235.1">
        <property type="nucleotide sequence ID" value="XM_712142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A660"/>
    <dbReference type="FunCoup" id="Q5A660">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A660"/>
    <dbReference type="EnsemblFungi" id="C4_04520W_A-T">
        <property type="protein sequence ID" value="C4_04520W_A-T-p1"/>
        <property type="gene ID" value="C4_04520W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641110"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404520WA"/>
    <dbReference type="CGD" id="CAL0000197682">
        <property type="gene designation" value="orf19.11312"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04520W_A"/>
    <dbReference type="eggNOG" id="KOG2809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052839_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A660"/>
    <dbReference type="OMA" id="PCWDQSS"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="PRO" id="PR:Q5A660"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="initiator methionine" description="Removed" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000324884" description="Protein PXR1">
        <location>
            <begin position="2"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="276" mass="31392" checksum="56A7DFF445142E37" modified="2005-04-26" version="1">MGLAGTKIKQRFGNDPRNTNWSNDTSRFGHQYLAKMGWQQGSGLGLVSHALTTHVKVSIKDDNLGLGAKLHKRKANGDGGLEEEGTAGLDAFQRILGRLNGKENVVNKVLDNVRDDDIINGKWGMRFVKGETLSSTWDKESKKLISYKNIEDDGKKSRKRKADESETKEDKKTLKKHKKEKKDKKEKKEKKKKKEKKDKKDKKDKKNKKDKKDKKDKKDKKDKIRTGSDETLVSKESSATPPPIATRLSARSKWIKQKRASVMDSKALNEIFMITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7K5</accession>
    <name>Q5A7K5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C300150WA</name>
        <name evidence="2" type="ordered locus">orf19.5461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717832.1">
        <property type="nucleotide sequence ID" value="XM_712739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7K5"/>
    <dbReference type="GeneID" id="3640595"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300150WA"/>
    <dbReference type="CGD" id="CAL0000185811">
        <property type="gene designation" value="orf19.5461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00150W_A"/>
    <dbReference type="HOGENOM" id="CLU_1510385_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A7K5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="178" mass="18814" checksum="1194A810B30933DD" modified="2005-04-26" version="1">MVACFDDGVNTAAFGFNLYVFGSFLVWSCCFFKISSCFILSLAKIGNKSCGILCGILKLALNSRNELISLCAFNLNDSFGTGGFGGIDSGFACFELDTIAGSWWWCVVVPCCAGFEISAFLNAAINSSPLLSTPEYLSSSSTPLSSTTTPLSSKMCRSVVACCSISLAILSALATRSW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7N3</accession>
    <accession>A0A1D8PIW3</accession>
    <name>MZM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MZM1</name>
        <name type="synonym">FMP16</name>
        <name type="ordered locus">CAALFM_C300340WA</name>
        <name type="ORF">CaO19.12888</name>
        <name type="ORF">CaO19.5433</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717805.1">
        <property type="nucleotide sequence ID" value="XM_712712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7N3"/>
    <dbReference type="SMR" id="Q5A7N3"/>
    <dbReference type="FunCoup" id="Q5A7N3">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A7N3"/>
    <dbReference type="EnsemblFungi" id="C3_00340W_A-T">
        <property type="protein sequence ID" value="C3_00340W_A-T-p1"/>
        <property type="gene ID" value="C3_00340W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640544"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300340WA"/>
    <dbReference type="CGD" id="CAL0000189259">
        <property type="gene designation" value="orf19.12888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00340W_A"/>
    <dbReference type="eggNOG" id="ENOG502S6EF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147114_2_2_1"/>
    <dbReference type="InParanoid" id="Q5A7N3"/>
    <dbReference type="OMA" id="KYKLRIH"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="PRO" id="PR:Q5A7N3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000405488" description="Mitochondrial zinc maintenance protein 1, mitochondrial">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="117" mass="13092" checksum="8B1183CAE4DA50A9" modified="2005-04-26" version="1" precursor="true">MSSVLSAYRNALRATKVAFRQDLPILQAARVQLKQGIRDNSNLQAQPEIEEAVQKLNEVAKFLIQNIVQGEKQQDGKYFLNFHEKTELGDNETIKQGRKEMGSLAGKKGSSIKSCND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-06-26" modified="2025-04-09" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AA09</accession>
    <accession>A0A1D8PDQ4</accession>
    <name>PGA26_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Predicted GPI-anchored protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGA26</name>
        <name type="ordered locus">CAALFM_C105760CA</name>
        <name type="ORF">CaO19.10012</name>
        <name type="ORF">CaO19.2475</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="1451" last="1469">
            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
            <authorList>
                <person name="Lan C.Y."/>
                <person name="Rodarte G."/>
                <person name="Murillo L.A."/>
                <person name="Jones T."/>
                <person name="Davis R.W."/>
                <person name="Dungan J."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="15387822"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="FEMS Yeast Res." volume="11" first="389" last="397">
            <title>Pga26 mediates filamentation and biofilm formation and is required for virulence in Candida albicans.</title>
            <authorList>
                <person name="Laforet L."/>
                <person name="Moreno I."/>
                <person name="Sanchez-Fresneda R."/>
                <person name="Martinez-Esparza M."/>
                <person name="Martinez J.P."/>
                <person name="Arguelles J.C."/>
                <person name="de Groot P.W."/>
                <person name="Valentin-Gomez E."/>
            </authorList>
            <dbReference type="PubMed" id="21439008"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2011.00727.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Fungal Genet. Biol." volume="43" first="124" last="134">
            <title>Genomic response programs of Candida albicans following protoplasting and regeneration.</title>
            <authorList>
                <person name="Castillo L."/>
                <person name="Martinez A.I."/>
                <person name="Garcera A."/>
                <person name="Garcia-Martinez J."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Valentin E."/>
                <person name="Sentandreu R."/>
            </authorList>
            <dbReference type="PubMed" id="16455273"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2005.12.002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">GPI-anchored protein involved in proper cell wall integrity. Does not seem to be directly involved in the synthesis of the cell wall. Required for normal virulence in a mouse model of disseminated candidiasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <topology evidence="6">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2 3 5">Induced during cell wall regeneration. Expression is also increased under high-iron conditions. Repressed by the HAP43 transcription factor.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to hyperfilamentation, increased biofilm formation and reduced virulence in a mouse model of disseminated candidiasis. Also leads to increased susceptibility to antifungals (fluconazol, posaconazol or amphotericin B) that target the plasma membrane and to altered sensitivities to environmental (heat, osmotic and oxidative) stresses.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718496.2">
        <property type="nucleotide sequence ID" value="XM_713403.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AA09"/>
    <dbReference type="STRING" id="237561.Q5AA09"/>
    <dbReference type="GlyCosmos" id="Q5AA09">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_05760C_A-T">
        <property type="protein sequence ID" value="C1_05760C_A-T-p1"/>
        <property type="gene ID" value="C1_05760C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639890"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105760CA"/>
    <dbReference type="CGD" id="CAL0000181671">
        <property type="gene designation" value="PGA26"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05760C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQ2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119130_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AA09"/>
    <dbReference type="OrthoDB" id="4026603at2759"/>
    <dbReference type="PHI-base" id="PHI:3516"/>
    <dbReference type="PRO" id="PR:Q5AA09"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000422910" description="Predicted GPI-anchored protein 26">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000422911" description="Removed in mature form" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15387822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16455273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21439008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="131" mass="13509" checksum="ECEDD1866E1E83B4" modified="2017-04-12" version="2" precursor="true">MHFSKIIAGSALSSVALAEFQNGTVTTHVTATGYTTYCPYPTTITLTICEEENICTKRPIVVSEPTTVTVTEPCIISTSYETTEVVVTTTLPSSLSPSSVAPANVTSFEGAGSKNVASALVGVVAIAAAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AA37</accession>
    <name>Q5AA37_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C105980WA</name>
        <name evidence="10" type="ordered locus">orf19.9983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718470.1">
        <property type="nucleotide sequence ID" value="XM_713377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AA37"/>
    <dbReference type="SMR" id="Q5AA37"/>
    <dbReference type="FunCoup" id="Q5AA37">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AA37"/>
    <dbReference type="GeneID" id="3639872"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105980WA"/>
    <dbReference type="CGD" id="CAL0000188838">
        <property type="gene designation" value="orf19.9983"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05980W_A"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009049_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AA37"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070786">
        <property type="term" value="P:positive regulation of growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="240"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000188838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="696" mass="80368" checksum="277AEECDBE9619BB" modified="2005-04-26" version="1">MPYSNPDSSVSNHDMNSVSPKTTTTNNTSPFATLASTMGKTTIDPETETEHNQGEGNDDQEITINGKATASESTTRPIFHVNSLSKSWHYDTSNSASSKSAPNTPKIKSQSQPVSRRASVDDIHFQHIPSHQETHNYSFKNSVLIPAAKWAYSPISKIRGSTSSSIKNTPLHEEYLIEYSVFRPIKGLPELNSHKDILIHLRDTIESETNKPFEFPETYISEIDFHNLLFKITKIIETDHIYPERISTGSSGSYFIFDIDFSLYKIGIFKPKDEEPYGPLSPKWTKWAHRTFFPCFFGRSCLIPNLGYISETAACVLDRQLQSYIVPHTEIVELRSPTFFYSYWDKSNDVTKLPKKKGSFQLFLKGYINADIWLKIYPIPTNDVCLLKKTSRIEVPLGETKFLFTWSQESMQQFQEELEKLVILDYLMRNTDRGLDNWMIKLEWIEIKRKQSTKIMKPIIKIGAIDSGLAFPWKHPDEWRSFPFGWLFLPLSIIGQPFSRRTRNHYLPLLTSKKWWEETVIKLKDVFMKDNDFKERMWLKQLAVLKGQAFNIVEILKLTYAGPLELTRRENLLVIDDIMYMPNGKCDYDFMKSSLYESDIFKSYRVKSTNRNHGGGDDNDEEGGQSETITQNTPLLTHPHNHYLEVINESMDDTNNESGYEHMNRENNVAATDKGKKVIIERLIKETSKPPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD02</accession>
    <name>Q5AD02_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C200630CA</name>
        <name evidence="9" type="ordered locus">orf19.9612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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                <person name="Martchenko M."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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    <dbReference type="GeneID" id="3638909"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200770WA"/>
    <dbReference type="CGD" id="CAL0000200626">
        <property type="gene designation" value="orf19.9595"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00770W_A"/>
    <dbReference type="eggNOG" id="KOG3274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052828_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AD20"/>
    <dbReference type="OMA" id="LFITWNK"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.700.20:FF:000004">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000200626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="208" mass="23976" checksum="BDB0BC0B047B6B71" modified="2005-04-26" version="1">MSKALSCYAFESLLFKLNLESNKIPLSKYFETLHESFTALPSRAPLFITWNKNHQLRGCIGTFSPLPIESGVSRYALHAALQDPRFFPISTSEVESLEVSVTLLDNFVTIDNPLDWEIGVNGLKISFQLNNEHYSGTFLPSVAEEENWDKLTTLHYLLKKADYPVSQKNVSQFYEKGLNEGWLELTRYDGLKNRLDYNEFIRIRNQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD21</accession>
    <name>Q5AD21_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pot1-2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">POT1-2</name>
        <name evidence="11" type="ordered locus">CAALFM_C200780WA</name>
        <name evidence="10" type="ordered locus">orf19.9594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719495.1">
        <property type="nucleotide sequence ID" value="XM_714402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD21"/>
    <dbReference type="SMR" id="Q5AD21"/>
    <dbReference type="STRING" id="237561.Q5AD21"/>
    <dbReference type="GeneID" id="3638908"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200780WA"/>
    <dbReference type="CGD" id="CAL0000175559">
        <property type="gene designation" value="POT1-2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00780W_A"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AD21"/>
    <dbReference type="OMA" id="DIIMGCV"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="PHI-base" id="PHI:3689"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF9">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="271"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000175559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="393" mass="41536" checksum="E2FF8841FCAFB45A" modified="2005-04-26" version="1">MFKKSANDIVVIAAKRTPITKSIKGGLSRLFPEEILYQVVKGTVSDSQVDLNLIDDVLVGTVLQTLGGQKASALAIKKIGFPIKTTVNTVNRQCASSAQAITYQAGSLRSGENQFAIAAGVESMTHDYFPHRGIPTRISESFLADASDEAKNVLMPMGITSENVATKYGISRKQQDEFALNSHLKADKATKSGHFAKEIIPIQTTDENNQHVSITKDDGIRGSSTIEKLGGLKPVFKDDGTTTAGNSSQISDGGSAVILTTRQNAEKSGVKPIARFIGSSVAGVPSGLMGIGPSAAIPQLLSRLNVDTKDIDIFELNEAFASQSIYCIEKLGLDYDKVNPYGGAIALGHPLGATGARVTATLLNGLKDQNKELGVISMCTSTGQGYAALFANE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD72</accession>
    <accession>A0A1D8PGB3</accession>
    <accession>Q5ADK0</accession>
    <name>MNN24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Alpha-1,2-mannosyltransferase MNN24</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MNN24</name>
        <name type="synonym">MNN2</name>
        <name type="synonym">MNN22</name>
        <name type="ordered locus">CAALFM_C201300CA</name>
        <name type="ORF">CaO19.1995</name>
        <name type="ORF">CaO19.9547</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003276" last="E1003276">
            <title>The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans.</title>
            <authorList>
                <person name="Hall R.A."/>
                <person name="Bates S."/>
                <person name="Lenardon M.D."/>
                <person name="Maccallum D.M."/>
                <person name="Wagener J."/>
                <person name="Lowman D.W."/>
                <person name="Kruppa M.D."/>
                <person name="Williams D.L."/>
                <person name="Odds F.C."/>
                <person name="Brown A.J."/>
                <person name="Gow N.A."/>
            </authorList>
            <dbReference type="PubMed" id="23633946"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003276"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719445.1">
        <property type="nucleotide sequence ID" value="XM_714352.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD72"/>
    <dbReference type="STRING" id="237561.Q5AD72"/>
    <dbReference type="GlyCosmos" id="Q5AD72">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C2_01300C_A-T">
        <property type="protein sequence ID" value="C2_01300C_A-T-p1"/>
        <property type="gene ID" value="C2_01300C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638789"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201300CA"/>
    <dbReference type="CGD" id="CAL0000192056">
        <property type="gene designation" value="MNN24"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01300C_A"/>
    <dbReference type="eggNOG" id="ENOG502SJ0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AD72"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="PHI-base" id="PHI:2885"/>
    <dbReference type="PRO" id="PR:Q5AD72"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000428638" description="Alpha-1,2-mannosyltransferase MNN24">
        <location>
            <begin position="1"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="31"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23633946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="709" mass="83023" checksum="98EEADE8F6041821" modified="2005-04-26" version="1">MFSIPVSSKTVRLILVSLLLITLINILAAFQRSTLSSWFPSSRHIINKFTDLRLALSSQESVLRDEEGEIYSLVGYHHDFDSNLVVVQKQYLLEKTPNEDTTEHFWNFLQSNFETKSEYDLNLIDGYNYKKLIKHLNEQNELQLSHSFVEQYKMENQFIQSFQNFFVQLIDTIEDCKPDLDPINNDNHYPNGDKIVKYYELRNKIPSENMKQFNIERLIHRNGRIPIYGGHLREQYKDELIRNKEFLSMYLTLSDSEISALKKSHTKFLETMMENWPENLFKFNKFNNFMKGDGIVYLGGGKYNQLVLLSIKILRENGSRLPVEVIIPYKNDYDIQFCDRVLPTLNGKCKLMTDYLPQTFVDKISGFQLKNIALLISSFERILYLDADNIPIRNPDVLFTNAPFTTKHLVVWPDLWRRSTSPHYYTIAGIEVDPNFKVRNSYVDGDERGKYTDSMYYSYHDCKGSIPEASSETGQLLINKKIHFQTLILAMYYNYYGPDYYYPLFSQGAAGEGDKETFIAAAHKLDLPYYQVGEFNREFGPINDNTRKHEFYGMGQYDPIIDYYMSTITTTQKDTKKKINYNSPLPEKYAANDEDDTCSNYDFHLFQSSSLFFLHANWPKYYIEKLFLYSYDEDRGPVTNDGDKRRLYGNELKKELGGYDFELNIMKNLHWCFCEEPLIDLIGIPVVGSKTRTDVCIAIKNHIEFLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AF52</accession>
    <name>Q5AF52_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C402460WA</name>
        <name evidence="12" type="ordered locus">orf19.10270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720506.1">
        <property type="nucleotide sequence ID" value="XM_715413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AF52"/>
    <dbReference type="SMR" id="Q5AF52"/>
    <dbReference type="FunCoup" id="Q5AF52">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AF52"/>
    <dbReference type="GeneID" id="3637844"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402460WA"/>
    <dbReference type="CGD" id="CAL0000188440">
        <property type="gene designation" value="orf19.10270"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02460W_A"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AF52"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000188440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24829" checksum="3F45882C72196167" modified="2005-04-26" version="1">MNIFRFFGDLSHLASIFILLYAIETNRSTNGLSLKTQILYVVVYFTRYLDLFTKFYSLYNTSLKLVFIASSIYTVYVMVYKYKKPIQENIDNFPLKYLIGGAILASLIFTHKYSIGEIVWSFSLWLEAVSILPQLYILQKTGEAENITTHYIFALGIYRALYIPNWIYRYFAEGHFDFVSVLAGLLQTGIYSDFFYIYYTKVMKGKKFELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFB9</accession>
    <name>Q5AFB9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nan1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">NAN1</name>
        <name evidence="10" type="ordered locus">CAALFM_C403030CA</name>
        <name evidence="9" type="ordered locus">orf19.10203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720441.1">
        <property type="nucleotide sequence ID" value="XM_715348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFB9"/>
    <dbReference type="SMR" id="Q5AFB9"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFB9"/>
    <dbReference type="GeneID" id="3637932"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403030CA"/>
    <dbReference type="CGD" id="CAL0000198224">
        <property type="gene designation" value="NAN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03030C_A"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348179_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AFB9"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005730">
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="term" value="P:positive regulation of rRNA processing"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
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    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
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    </dbReference>
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        <property type="entry name" value="WD40"/>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000198224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="839" mass="94048" checksum="F01C8BA6FF1779E4" modified="2005-04-26" version="1">MPSAISEWSLSMATGGKPLYLPCSQTTASVYSQDGRYVIIALTHQLRVYFISTRQCIKTIDLDLHDLADLKIDVTNGNQVLLFKTSGEILTVNWKDKVSQPIISTIDINKTQSGTSLPLLSVISVKHLFFIIVTGRKEKKKGTPHTRYINYFDRNSESLVPIIEVANSINFATSLDNTKIAFITSGNEIDLFDLSGIFNVDSIENLSDNDIVKETIPFVYRSPVTSIAVSNDSMIAIGTSAGPIQIVYGGLTTPKPQRVLKWHLDQVKGLMFTADNNYLLSGGMEKVLVFWQLETEKKQFLPRLNGVIDKISIDNYKNDYISLQLNVDPLDNNYEILVLSAVDLVSRLSVNTVRPKFAYNIATTLSKTKKKFIKSSSDFDKFKIRYDYTSQFEIHPKTKSMYFPNGALIQSFDLFKNEQNFIQHGAPVLGVGKVRSETKLLDPLVTLLKFTHDGEWMCTFDEFTNTEVDSLLLKNEKQYALKFWKYVGHKENATSGINNNNKTGHWELTTKIIDPHGMNPILAMIPAPTSYFNGLAFLTADDKGGLRIWRPSVPKEQYKTTSARSQQTAWTLRKSRAPSALSSDAVALSWSDDNSLIFLAHECSILTIDSKSFEEIPDFKIPSLSGSRVRSLNMVNNNLIVLSKTRISSFDLITGELTSLVAKVNTTIGAKNLIAIDPIKRLICLALNYYSEENNTLSIKSKILIFKPNQLKPICVQLHEQGVSSIRYFNSSFVFVDLDCRVGTIYSNEEITETIELGLTQEINNMLIAAQATADVINDRNVKTTVGHQNGNKEGEMDIDNSMAYAAKVVDLHTFQPIFQNIEGVQVESLFERIVNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFC5</accession>
    <name>Q5AFC5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIA large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C403090WA</name>
        <name evidence="7" type="ordered locus">orf19.10197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720435.1">
        <property type="nucleotide sequence ID" value="XM_715342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFC5"/>
    <dbReference type="SMR" id="Q5AFC5"/>
    <dbReference type="FunCoup" id="Q5AFC5">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFC5"/>
    <dbReference type="GeneID" id="3637926"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403090WA"/>
    <dbReference type="CGD" id="CAL0000181129">
        <property type="gene designation" value="orf19.10197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03090W_A"/>
    <dbReference type="eggNOG" id="KOG2652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030027_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AFC5"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000181129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="275" mass="30372" checksum="9EFA7ED4FE065D66" modified="2005-04-26" version="1">MSNTETSKLYESVIEDVINDSRQDFENNGIDESTLQELRRIWCEKLTQSGVAKFSWDEEEEEEEPVEQVDVDVEVGQSAQQAAEQPQAAINDTGATESNTSATTETTVKKEATASNSGLPDAQLSYNTTDSLGIEIPSISREKANGTEGTDKNGDGDGGDNHGLIVPKIEQADGPIFFDNKQFKSNKKLSQVDGESEFDEFESDGDLSDDINSELDSDSDKEEEDDDEEETNFALCLFDKVQRIKNKWKSTLVAGIANINGKDYVFHKANGESEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AG51</accession>
    <accession>Q96WX3</accession>
    <name>Q5AG51_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cu(2+)-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">CCC2</name>
        <name evidence="14" type="ordered locus">CAALFM_C503020WA</name>
        <name evidence="13" type="ordered locus">orf19.11803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW29722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_715541.2"/>
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    <dbReference type="STRING" id="237561.Q5AG51"/>
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        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
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    <dbReference type="GeneID" id="3637821"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503020WA"/>
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        <property type="gene designation" value="CCC2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C5_03020W_A"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="C:membrane"/>
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        <property type="term" value="C:trans-Golgi network transport vesicle membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:copper ion binding"/>
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        <property type="term" value="F:P-type divalent copper transporter activity"/>
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    </dbReference>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="term" value="P:copper ion homeostasis"/>
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        <property type="term" value="P:glycerophospholipid metabolic process"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
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    </dbReference>
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        <property type="term" value="P:prostaglandin metabolic process"/>
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        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000005">
        <property type="entry name" value="Copper-exporting P-type ATPase A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
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        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000193278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1204" mass="131383" checksum="906F3CC2F92DB47B" modified="2005-04-26" version="1">MKSSAILESNPNQNNNVTVVLEVLDLHTAKDITDVINILDELFPKLKSKDFDHQELTLIYDSNDYDDMSILNAISEIGFPVKILSSTAPQCKTTVNIQGMTCGACSASITEALEKTPGVYKASISLVTENGLIMHSPKLSPENIITIIEDCGFDAQIESSKTKQSSAPESSQDQSKRLNTTIGIIGMTCGACSASITNVLEKLPGVENVSVSLITEEASIVHDSTITTVQQLKEAIEDCGFTPTFNKSINLNQYQNTNDSNEEVTLKIVGVNHTTDLIGLRYNIEAYLRSISGVQKFELTLRGMNASSNIMPTQVGTLITEEDTIADVKSLVNELVFQYDSDSVGIRDIIDGLNTISDNIEFMVINSLDQSSATQLKLLSKVKDINYWKKIFIQSLLFGIPVLFLNHTKNWPIWKTTMIFPGLYLVSLLELILSTYIQFYLGSVFIKKFSSFLRKKFKGATMDVLVCISTMCSYIFSLTTIIVSVWNGQKNGPPPVLFDTLVMLISFVSFGKLLENKAKGATSTALSSLLSLTPSTCTIINDIPGYQKFIEDQQSLEKSEKSNSLSMQEFPTRVISIDLVQPNDIAIVLPGGKVPADGEIVFGETEIDESLITGEPLPVYKKLKDKVIGGSINGPHLIHIKVTHTGKKSQLQQIINLVKESQVNKAPVQKFSDYIAARFVPFVLLLAIFTFILWMIICFTIHQDKLPKIFQNETNGKFFVCLKLSISVIVVACPCALGLAAPTAVMVGTGVGAINGVLIKGAKVLEKITGVNIILFDKTGTLTTGEMSLVNFQPIMSKSSITISDWWKLVGSVECHSEHPIGRALTKSAKTNLNLNFDDDHFDTTVNDINVLIGLGIQANVTLANNPQTQFNVYVGNDKLIESKFPNLLNNIDEKLLHSANTVSHVIIDGEYSGYIELTDALKSGSWEVVNYLKTQGYIVGMVTGDNRGAALKIAQEVGIPFDNVFYEVSPIHKDNVITDLHNRLGGNQSSSVNVAFIGDGINDAPALAKADIGMAISSGTDIAIESADIVLIGGRSNQTDLHGVVNALQISTATFNRIKINFLWAIIYNIFMLPFAMGCFLPLNIVLPPVAAGAAMMFSSLSVVFSSLLLKRWTPPKIETKKTFIDDLEMGNNATGGDGDGFSLKNGTIEEFNNVKRKSAVNFSSLFAKMTTTRRNRRGGGGGGGRSNGNNNQSYELVSNRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH13</accession>
    <accession>Q3MPE7</accession>
    <name>Q5AH13_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C701960WA</name>
        <name evidence="7" type="ordered locus">orf19.13878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721363.1">
        <property type="nucleotide sequence ID" value="XM_716270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH13"/>
    <dbReference type="STRING" id="237561.Q5AH13"/>
    <dbReference type="GeneID" id="3636969"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701960WA"/>
    <dbReference type="CGD" id="CAL0000174006">
        <property type="gene designation" value="orf19.13878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01960W_A"/>
    <dbReference type="eggNOG" id="ENOG502S7ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025507_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AH13"/>
    <dbReference type="OMA" id="YWKIFIN"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000174006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="684" mass="78435" checksum="1627F65247F66B07" modified="2005-04-26" version="1">MANPTTHDNSIDDNTNATSQKFTSNTKRKNKRNKQRYKNKSQHFNKPTESSQKSPESSIMADDDVTDHQVQQQTTDRDNSTNLNMTTVTTTTPPPPPPPPPPQHAQEANVYKSPRKEAIMRYKQNHDNTFNQLFDIKENLKSKENDDKQSQLQQATGGNQVNSNHNNGNHNISLDLDEKVTLFKYKSSKILELVNQNNANGSLLAHGIFEIFQLHQGDVTYLSCGNNFIYPLLPKIKVFRINSNQFLLPLVNPERYWKIFINSEELNVINNLINVFQRNVQFISLHESENKNAPEPKSQFEFTDSINTKPKELESPPRNIYISNEIPDSPPSAPISPGHIQTTFHLSPQGRVASHQHRQQQGQAFPDTLSQPHLYKKESMQSLNTNIACLDINSKLLLHQPKPKKPLSSNQAYNLRHNQNQNQNYNHNHGHSQKYPAIDEKSESSMDSLLDEYEENIHKSMTIASRPQSRQPSIVSAHHKRLPATHYNRSHYNNQGNLNDDGVAQYYPTETRTQQFPQSNNGHNRSRRSSKSDLYINESGWMEPNLNSQTHNYNNNNYKKIPKSRSTYSINSATTDLYQIYKNIPLRNSEIDRRDEDSKSIKSMSRLPSARTLSIYQSDMNRRRQSAYFASTAKTNPKLNSDVKLNSQEIYRMLSSKPDKPVLKTPMNDNAVKNSGFAARLFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH78</accession>
    <accession>Q3MP91</accession>
    <name>Q5AH78_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C702550CA</name>
        <name evidence="4" type="ordered locus">orf19.13813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721298.1">
        <property type="nucleotide sequence ID" value="XM_716205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH78"/>
    <dbReference type="SMR" id="Q5AH78"/>
    <dbReference type="FunCoup" id="Q5AH78">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AH78"/>
    <dbReference type="GeneID" id="3637018"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702550CA"/>
    <dbReference type="CGD" id="CAL0000192754">
        <property type="gene designation" value="orf19.13813"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02550C_A"/>
    <dbReference type="eggNOG" id="KOG3381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075876_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AH78"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000192754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="222" mass="24231" checksum="A0A606C657AC9A29" modified="2005-04-26" version="1">MSDPINANPTIIDVADLPTRLNNDNNNNNDNNYQTTNKLNLKKNKQMISQLVSLSLLNPDESPEAADDETSLSSDEENEDDDFDPIDEQEIFDLIATISDPEHPLTLAQLAVVNLSDIKITNPPNCGGDGGDGGGGGISEVLIKITPTITHCSLATLIGLGIRVRLDRSLPSRYRIKILIKEGTHQSENQVNKQLNDKERVAAACENDQLLNVISQMLSTCK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2025-04-09" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK97</accession>
    <accession>A0A1D8PNZ0</accession>
    <accession>Q5AKR0</accession>
    <name>PGA37_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Predicted GPI-anchored protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGA37</name>
        <name type="ordered locus">CAALFM_C504370CA</name>
        <name type="ORF">CaO19.11405</name>
        <name type="ORF">CaO19.3923</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Curr. Biol." volume="19" first="436" last="441">
            <title>Specialized sugar sensing in diverse fungi.</title>
            <authorList>
                <person name="Brown V."/>
                <person name="Sabina J."/>
                <person name="Johnston M."/>
            </authorList>
            <dbReference type="PubMed" id="19249212"/>
            <dbReference type="DOI" id="10.1016/j.cub.2009.01.056"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E17046" last="E17046">
            <title>From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells.</title>
            <authorList>
                <person name="Wachtler B."/>
                <person name="Wilson D."/>
                <person name="Haedicke K."/>
                <person name="Dalle F."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="21407800"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0017046"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text>Predicted GPI-anchored protein which may have a role during host infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <topology evidence="6">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5">Repressed by HAP43. Down-regulated during oral epithelial infection. Up-regulated in response to galactose.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PGA37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721833.1">
        <property type="nucleotide sequence ID" value="XM_716740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK97"/>
    <dbReference type="STRING" id="237561.Q5AK97"/>
    <dbReference type="GlyCosmos" id="Q5AK97">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C5_04370C_A-T">
        <property type="protein sequence ID" value="C5_04370C_A-T-p1"/>
        <property type="gene ID" value="C5_04370C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636484"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504370CA"/>
    <dbReference type="CGD" id="CAL0000201918">
        <property type="gene designation" value="PGA37"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04370C_A"/>
    <dbReference type="HOGENOM" id="CLU_114600_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AK97"/>
    <dbReference type="OrthoDB" id="10543007at2759"/>
    <dbReference type="PRO" id="PR:Q5AK97"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424949" description="Predicted GPI-anchored protein 37">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424950" description="Removed in mature form" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19249212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21407800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="208" mass="20615" checksum="1BFEA3E182CF609C" modified="2005-04-26" version="1" precursor="true">MLFTQLIILLTVTSQALSVTISDLNNIASNQVTKRLGGGSRGGSSSGSRGGSSSGSSSGSSSGSRGGSSSGSSSSGSRGGGSGSSSSSGSRNWGSNQYHCSGNSCGYGNYYAPSTAAAAVGYGTGRYTGGTQYGNNQYHCSGSTCGYGNYFAPSAAAAAAGYGSARYYAQHHNSTSSESETISGSSSLNIPSTHFYLIGFAAAYSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMD9</accession>
    <name>Q5AMD9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C400850CA</name>
        <name evidence="5" type="ordered locus">orf19.12178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722772.1">
        <property type="nucleotide sequence ID" value="XM_717679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMD9"/>
    <dbReference type="SMR" id="Q5AMD9"/>
    <dbReference type="STRING" id="237561.Q5AMD9"/>
    <dbReference type="GeneID" id="3635718"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400850CA"/>
    <dbReference type="CGD" id="CAL0000196827">
        <property type="gene designation" value="orf19.12178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00850C_A"/>
    <dbReference type="HOGENOM" id="CLU_014743_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AMD9"/>
    <dbReference type="OMA" id="MSDAHIQ"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971243" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="335"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000196827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="712" mass="82842" checksum="E6440DA7192765C6" modified="2005-04-26" version="1">MQANFLLAFICFAAAAVIAQVVPNVEQLKAQSLQKRDEDLMEPVFKNLPSKDYDYIMYQLKQLQIAKGNVSKCDQCKNKMRFVKKLIDEKPEKAHLTTLMMYKDCVLSTTPYMYCTIGNFFVTTKAYTDKKFDQKFESGIDGYEVVDFLDNDFLDFLGRFNTSDEFDLEYYCHAQMGSCDLPDLEAVVDSFNIESWWPEKKPQHYSEPKYNKTNRERFNVLHMSDAHIQFTYEQGTEAKCSQLVCGLTKSFNKKLVEQNYNFTSAFAADNPNKSPKDFKFSFYPDAHYDGQKYVKGEYYDFPKSRGWNFNFQPATVFGAYLSDTPEILVNNSLIEMAKMHKDKNFEFALYNGDTAEHDLQSVTVDLVKSEEIRTFKTMRQYLNGIPVLPSMGNHDTAPYGLLAPLRLDYNNSYRWNNDEMVDVWIGNEWFKQSEKQTMKDHYAAFSYETERGLKVITLNSNTYYQSNTWRFLNASSDPDLFGGWKFLVDELIESEKKNQRVWISAHVPPNKDDVMPIDSLIFQKIVQRFAPYTIANLYYGHTHNDQKIVAYSDAKSPKPNQPITSAWVIQSLTPFGNHNPAFRYYEVEDESFNIMNSFNYYTKLNETYVNGGEEPVWEYEYSARAAYDPNNEWPVSAPLNATFWDKFAISKMKDPTNIKFNQMYTDYQYRFSPYTPNCTHPSGKNITTSCYVNNYCNAANLDIVSVEECMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMG7</accession>
    <name>Q5AMG7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Agp2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">AGP2</name>
        <name evidence="12" type="ordered locus">CAALFM_C401100CA</name>
        <name evidence="11" type="ordered locus">orf19.12148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722748.1">
        <property type="nucleotide sequence ID" value="XM_717655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMG7"/>
    <dbReference type="SMR" id="Q5AMG7"/>
    <dbReference type="FunCoup" id="Q5AMG7">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AMG7"/>
    <dbReference type="GeneID" id="3635684"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401100CA"/>
    <dbReference type="CGD" id="CAL0000191370">
        <property type="gene designation" value="AGP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01100C_A"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="Q5AMG7"/>
    <dbReference type="OMA" id="WIVNLCT"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="57"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000191370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="568" mass="63780" checksum="66ECE6C94DB57B41" modified="2005-04-26" version="1">MWNKEKSKEAEKGEIREDELFNTKVDRQTSASSESSLVHDNSSVDTDHTQRKLYNRHLQLIAIGGSIGTGLFVTIGTTGLTVGGPLGLLLSYCLSTLLTLLLTSAVGEMVSYMPVDSPFLNMAGRVIDPAFEAAASVNFWVMQSLYIPFEITAVNGMIHFWRDDYSPAITFCIQIAIYAAINLYAVRVFGECEFWFSLAKLILCIGLLFFTLVTMCGGNPKHDAFGFRNWHAAGGPIATLYTTGSLGRFQGFLGSFRWSSSFTCVGSEYLGMTAGECINPRHNLPIAFRTVLYRLVLFYIGGALSVSILVAYNDPKYLELTSDTSNAASSPYVVAMQNLGINVLPHIVNAVILTSAFSAGCSYTYTSSRCLYNLAKKGFVPKFFKKCTSHGVPVFCVGLSICFSLLSLMQLGSSGSKVLNYMVNLCTGAQILNYAFMSITYIGFYHACKAQNIDRHQFTYRSWFQPYSIYFVCFMYWCLVGILGYNVFMPGKWSVDTFLYNYIMVFVSLAVFIAWKLFRRTKFIKPIDADLRTGLEEIERHEYEYYEQLEQSSNKPDNKFKSILHWIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMH1</accession>
    <name>ASK1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DASH complex subunit ASK1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Outer kinetochore protein ASK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ASK1</name>
        <name evidence="7" type="ordered locus">CAALFM_C401150WA</name>
        <name evidence="6" type="ORF">orf19.4675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1295" last="1305">
            <title>The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere.</title>
            <authorList>
                <person name="Thakur J."/>
                <person name="Sanyal K."/>
            </authorList>
            <dbReference type="PubMed" id="21571923"/>
            <dbReference type="DOI" id="10.1128/EC.05093-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (By similarity). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (By similarity). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:21571923).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex (By similarity). Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore (By similarity). DASH complex oligomerization strengthens microtubule attachments (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Short, often misaligned spindles with an extensive network of cytoplasmic microtubules (PubMed:21571923). Cell cycle arrest in mitosis with unseparated DNA (PubMed:21571923). Inviable (PubMed:21571923).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722744.1">
        <property type="nucleotide sequence ID" value="XM_717651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMH1"/>
    <dbReference type="SMR" id="Q5AMH1"/>
    <dbReference type="STRING" id="237561.Q5AMH1"/>
    <dbReference type="EnsemblFungi" id="C4_01150W_A-T">
        <property type="protein sequence ID" value="C4_01150W_A-T-p1"/>
        <property type="gene ID" value="C4_01150W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635656"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401150WA"/>
    <dbReference type="CGD" id="CAL0000194135">
        <property type="gene designation" value="ASK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01150W_A"/>
    <dbReference type="eggNOG" id="ENOG502RZQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037658_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AMH1"/>
    <dbReference type="OMA" id="YHRVSIS"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000459456" description="DASH complex subunit ASK1">
        <location>
            <begin position="1"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P35734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9P6S5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21571923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000194135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="594" mass="67232" checksum="D3A5346B08137690" modified="2005-04-26" version="1">MKRYSIAPTSSRRKSAIDATLPESNLPARQILEQLDQDTTFVLQEIDKNISRANTVINDKIKPMIQEYAFQSWKVWENTGFWKHFFEQSANVELDSYVEPINEVNPQNNFLLLNEIEKNKQKGRYEDSRGSNKVNQANNDENNDIDNDEKEEPEIAFKKPNLRRLVADGNTPTWSTEHTKPSMKSIQLSPPKRMQTTNFTGGLARENTKLTDSITLEPPALSAETRAVTSSPHSRHYQNQHQRLQSRDSPIKIHTIRQSLDTYHRVSISPKKLKTPIRSTRTSRIESILNSSPILPEPPVLQSEIGSETPKYMSSSSPMKKQQQQQRESLNFQSDNDQQQGLQRFPNTPKYSRLSGSSVNSLLSNKSNLSDDEDDHINPPPQLDSDNHGVVIDNSDTNNNNGDSSDDLAALPVPELNTIDFKDKNSNNNNKRSIQSTPRSSEKKRRSINTKNTNNNNTSAAATAVVVDDDDDRENVFLDHSYKKTPDNQQSNNSTRFFSTGGSNNDNHTETQDNSKSFSQIYDEAISKIRGKKTTSQSNDQNGDEDGDVVMSLDMTVTKDLTGEPTKDLSKDLTENSTTDLGPFRERWKKLTRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMH6</accession>
    <accession>A0A1D8PL77</accession>
    <name>CAS5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell wall integrity transcriptional regulator CAS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Caspofungin sensitivity protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CAS5</name>
        <name type="ordered locus">CAALFM_C401190WA</name>
        <name type="ORF">CaO19.12140</name>
        <name type="ORF">CaO19.4670</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
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            <authorList>
                <person name="Muzzey D."/>
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                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="J. Infect. Dis." volume="200" first="152" last="157">
            <title>Candida albicans Cas5, a regulator of cell wall integrity, is required for virulence in murine and toll mutant fly models.</title>
            <authorList>
                <person name="Chamilos G."/>
                <person name="Nobile C.J."/>
                <person name="Bruno V.M."/>
                <person name="Lewis R.E."/>
                <person name="Mitchell A.P."/>
                <person name="Kontoyiannis D.P."/>
            </authorList>
            <dbReference type="PubMed" id="19463063"/>
            <dbReference type="DOI" id="10.1086/599363"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="PLoS Pathog." volume="2" first="E21" last="E21">
            <title>Control of the C. albicans cell wall damage response by transcriptional regulator Cas5.</title>
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                <person name="Bruno V.M."/>
                <person name="Kalachikov S."/>
                <person name="Subaran R."/>
                <person name="Nobile C.J."/>
                <person name="Kyratsous C."/>
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            </authorList>
            <dbReference type="PubMed" id="16552442"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.0020021"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1750" last="1758">
            <title>Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model.</title>
            <authorList>
                <person name="Pukkila-Worley R."/>
                <person name="Peleg A.Y."/>
                <person name="Tampakakis E."/>
                <person name="Mylonakis E."/>
            </authorList>
            <dbReference type="PubMed" id="19666778"/>
            <dbReference type="DOI" id="10.1128/EC.00163-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2014" name="Antimicrob. Agents Chemother." volume="58" first="6807" last="6818">
            <title>Disruption of the transcriptional regulator Cas5 results in enhanced killing of Candida albicans by Fluconazole.</title>
            <authorList>
                <person name="Vasicek E.M."/>
                <person name="Berkow E.L."/>
                <person name="Bruno V.M."/>
                <person name="Mitchell A.P."/>
                <person name="Wiederhold N.P."/>
                <person name="Barker K.S."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="25182640"/>
            <dbReference type="DOI" id="10.1128/aac.00064-14"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="499" last="499">
            <title>The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.</title>
            <authorList>
                <person name="Xie J.L."/>
                <person name="Qin L."/>
                <person name="Miao Z."/>
                <person name="Grys B.T."/>
                <person name="Diaz J.C."/>
                <person name="Ting K."/>
                <person name="Krieger J.R."/>
                <person name="Tong J."/>
                <person name="Tan K."/>
                <person name="Leach M.D."/>
                <person name="Ketela T."/>
                <person name="Moran M.F."/>
                <person name="Krysan D.J."/>
                <person name="Boone C."/>
                <person name="Andrews B.J."/>
                <person name="Selmecki A."/>
                <person name="Ho Wong K."/>
                <person name="Robbins N."/>
                <person name="Cowen L.E."/>
            </authorList>
            <dbReference type="PubMed" id="28894103"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00547-y"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION AT SER-769</scope>
        <scope>DEPHOSPHORYLATION BY GLC7</scope>
        <scope>MUTAGENESIS OF SER-769</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2021" name="Antimicrob. Agents Chemother." volume="65" first="0" last="0">
            <title>Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans.</title>
            <authorList>
                <person name="Xiong K."/>
                <person name="Su C."/>
                <person name="Sun Q."/>
                <person name="Lu Y."/>
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            <dbReference type="PubMed" id="33168610"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2021" name="J. Microbiol." volume="59" first="911" last="919">
            <title>The transcription factor Cas5 suppresses hyphal morphogenesis during yeast-form growth in Candida albicans.</title>
            <authorList>
                <person name="Kim J.M."/>
                <person name="Moon H.Y."/>
                <person name="Lee D.W."/>
                <person name="Kang H.A."/>
                <person name="Kim J.Y."/>
            </authorList>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5 6 7 8 9 10">Transcription factor that acts with ADA2 to promote cell wall integrity (PubMed:16552442, PubMed:28894103, PubMed:33168610). Regulates the expression of target genes in concert with the transcriptional regulators SWI4 and SWI6 (PubMed:28894103). Crucial for proper cell cycle dynamics and responses to echinocandins, which inhibit beta-1,3-glucan synthesis (PubMed:28894103). Has distinct transcriptional targets under basal and stress conditions (PubMed:28894103). Also regulates a transcriptional network that influences the response to fluconazole (PubMed:25182640). Plays a key role in adherence, hyphal development, and virulence (PubMed:19463063, PubMed:19666778, PubMed:22359502). Acts as a repressor of hypha-specific genes during yeast-form growth (PubMed:34491522).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">Localizes to the cytoplasm under basal conditions and translocates to the nucleus under cell wall stress.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Phosphorylation at Ser-769 and probably additional serine residues (PubMed:28894103). GLC7 dephosphorylates CAS5 in response to cell wall stress which leads to its translocation to the nucleus (PubMed:28894103).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4 5 6 7 8 9 10">Leads to sensitivity to caspofungin and affects expression of many genes including caspofungin-responsive genes (PubMed:16552442, PubMed:28894103, PubMed:33168610). Results in hyphal defect during C.elegans infection and exhibits attenuated virulence in flies and mice models for candidiasis (PubMed:19463063, PubMed:19666778, PubMed:22359502). Decreases the expression levels of a set of ergosterol biosynthesis genes, such as ERG2, ERG3, ERG5, ERG6, ERG11, and ERG24, resulting in the accumulation of lanosterol and zymosterol (PubMed:34491522). Impairs maintenance of the yeast form under non-hypha-inducing conditions (PubMed:34491522). Leads to increases susceptibility to fluconazole (PubMed:25182640).</text>
    </comment>
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        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19666778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="25182640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="28894103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="33168610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="34491522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="16552442"/>
        </source>
    </evidence>
    <sequence length="821" mass="92784" checksum="97E6299448FB60C7" modified="2005-04-26" version="1">MENYLLSSPTQLSQPYDDGTNSLLFMDNYELSQNLSQPLDQHLQSLQQQSQVQSQAPQQVQSLNQHQQLPQIQPFPTLVNNQQYAQETFQQLSQQHQQQQQQQQQFSPFQQSQLQQQFQYQYSQQQQQQHFQQPVTIEEEIVPASNNTNIQISKFFDDNKGDDEDIANSGNFNEFDHSRNISLDDTTITDLHRRENSINPPTGLPHSISSNTIYSYSSFESPQSHIQSQPSYSQGYHNQNSLSTPLRRNKSYSISSANFNQSPVNLATTAMNKIMKTPLRGHTRSRSKVDVNAAVTAAMNLGQATKSNSTSSYNSTLNPFYTPSQQLSSTDDDDISTPLLTPGTKLHTSKSTFFSPYNKDDLEDQDDDAVKQLRKAKSYTSLLRKKKREDMTPSKQNQQHQQQQQQQQQQQQSRQSGGGHIQNLSFPNSTSQPKIDLLAYDQNPMTSYPPMDKSILKNLNQSISPFNKPKLSPPPSNFPSISIDLTTIATNKSSSFSSSTTHRNYNENTPFNSANSTSGGLLPPMATFTVPTVIKEELQVHNLQEEEQEHQDEQMEIDSFESNEKNARPTLSTSSLVRSMKMANLEISNDQQMSSNEDENIVTEAVVKQEKNGPVVDDVNGTGTNSKKPRKKQKSKSKENCNKKGKVATGNGKDNDKNNECLVNKGNKTNNNDTSNDKLDNDNKNTNGNGNNDNDNDSEENNDNVDDADDDDDGTVTIPIPEDLNVTKVKVRNNRSKSNDKSDPKKKHKCPICESRFQRPEHVKRHLKSHSSEKPFECQMPNCGKRFNRKDNLKAHLKKIHGLVKGQEEFTRVLNENKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANH5</accession>
    <name>Q5ANH5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein P2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">RPP2B</name>
        <name evidence="7" type="ordered locus">CAALFM_C304680WA</name>
        <name evidence="6" type="ordered locus">orf19.13349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723140.1">
        <property type="nucleotide sequence ID" value="XM_718047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANH5"/>
    <dbReference type="FunCoup" id="Q5ANH5">
        <property type="interactions" value="1007"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANH5"/>
    <dbReference type="GeneID" id="3635195"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304680WA"/>
    <dbReference type="CGD" id="CAL0000199315">
        <property type="gene designation" value="RPP2B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04680W_A"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ANH5"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000199315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="111" mass="11177" checksum="230A832F5FF95210" modified="2005-04-26" version="1">MKYLAAYLLLVQGGNTSPSASDITALLESVGVEAEESRLQALLKDLEGKDLQELIAEGNTKLASVPSGGAAAGGASASAGAAAGGAAEAEEEKEEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANK2</accession>
    <name>Q5ANK2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C-like 1</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">PKC1</name>
        <name evidence="25" type="ordered locus">CAALFM_C304470WA</name>
        <name evidence="24" type="ordered locus">orf19.13322</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723115.1">
        <property type="nucleotide sequence ID" value="XM_718022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANK2"/>
    <dbReference type="SMR" id="Q5ANK2"/>
    <dbReference type="FunCoup" id="Q5ANK2">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANK2"/>
    <dbReference type="GeneID" id="3635210"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304470WA"/>
    <dbReference type="CGD" id="CAL0000201435">
        <property type="gene designation" value="PKC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04470W_A"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_54_0_1"/>
    <dbReference type="InParanoid" id="Q5ANK2"/>
    <dbReference type="OMA" id="QCTHLVP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090033">
        <property type="term" value="P:positive regulation of filamentous growth"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0090334">
        <property type="term" value="P:regulation of cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:2000769">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity regulating cell shape"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11621">
        <property type="entry name" value="HR1_PKC-like_1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000474">
        <property type="entry name" value="Serine/threonine-protein kinase N2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="C2_fungal_PKC"/>
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        <property type="entry name" value="HR1_rho-bd"/>
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    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="PKC-like_HR1"/>
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    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
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        <property type="entry name" value="Pkinase_C"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
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    </dbReference>
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        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="189"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="415"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="480"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="770"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="1030"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="304"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="548"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="724"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="799"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="CGD" id="CAL0000201435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AOW28465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125248" checksum="15B22E8B5955A037" modified="2005-04-26" version="1">MSTSQPSQQQNPEQVVNDIRQKIEKERKIIQGFNDVKRNTNNPEVIQKCKSKIIESQSMIDYYQETMNKLTRQMSRLNTNSSSRTASRSSVISEYKPSYSNFDLIKYECPSLGNKIQFMLQYLEFKLQVENKYSEANKKLSHLYLMDGDKSSSNAAEGGRAESDQRIQLLEKALKKYQKFSINDHEFDRDYEIMDSTKHSRKLLTGRLTVSITCIRDVDHIATALAKKRETVVVIKVDDLEKARTKPSKNDNWNEEMVIDVDKSHEIELAVMDKQNGIYVPVAVNWFSLFDLAEEIRKKKVAKDQGSSGWLPAANLPQTGGSGAGTGSSMTGGASYGATSPLPAHNDLRPSVSPSSDAKENKVSVSTWLSLEPGGQMLINLNFEKSITNGKQFRGPLGRHGAIRQKKEEVFEKHGHQFVQKQFYNIMSCALCGEFLRYTGYQCQDCKFLCHKKCYQKVVTKCISKSGSDYDAAQLNHRIPHRFEPITNHGTKWCCHCGYILPWGKKNVRKCTECGVMCHAQCTHLVPDFCGMSLQMANEILATIESTKVSPKKAQHQQSHAKPLPPKPPIESKPSMDSEETLHNEPSYKSLRPASVVHQDTNFVSKLPTTVQNKYQEPVELPPQQQNQVVPSTRRRGHGSTDLSFETGYGQQQHQHHRDVPQIVVEDHQHYNSNDNRDVEMEESKDEFDNFDYNNKYTENEILTDVQQDQVRSPFADQIQGVPETSHAKQQNQQVQQVQQQEELGHQRTHSSGKFGKSKRRKRKVGLDDFQFLAVLGKGNFGKVMLAESRHTSKLCAIKVLKKDFIVENDEAESVKSEKRVFLTANKEMHPFLLNLHCCFQTENRIYFVMEYISGGDLMWHIQKNRFTAKRAKFYACEVLLGLKYFHDNGIVYRDLKLDNILLTTKGHIKIGDYGLCKEDMWHKSTTSTFCGTPEFMAPEIVAGKAYDRSVDWWAFGVLLFQMLLCQSPFKGDDEDDIFNAIENDEVKYPINLSRQTVLVLQALLTKDPSQRLGSGPKDAEEIMEHPYFHDVNFDDVLNCRIPAPYIPEVQSEHDYSNFDKEFTSETPRLTPVETVLTSEMQEQFRGFSHISDNATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AP68</accession>
    <name>Q5AP68_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C110250CA</name>
        <name evidence="2" type="ordered locus">orf19.12360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718484.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AP68"/>
    <dbReference type="SMR" id="Q5AP68"/>
    <dbReference type="GeneID" id="3634882"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110250CA"/>
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            <end position="111"/>
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            <end position="38"/>
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            <begin position="95"/>
            <end position="104"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000178209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="273" mass="31240" checksum="1AC62EA44A8D965B" modified="2005-04-26" version="1">MGASTSKQGGRKLAKSVSESAAKTINRTSNVNQLPSQNLRDKFEQQHKDNSVSQGDEKSHQDEISQHSFRPDSTTKFDPKFLRKKLNNETTSAFEGKDGGDPHEQGTSTYDKSFIDSVSKLGTQIKTIEFDPYKDKNALPLRQLRSRKKLYDLGEQELKDLMEPTSSRNEVEKTMVHPQTLSAILRDLDDPRVDNKEIHKDYQLEPDFLKKLGTSIRLPKTTVVIEEVVKKDEVGHKKVVPRKRHEEAEIIEDNHGLEKDQYDKLKKRLSLDD</sequence>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_718418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APE0"/>
    <dbReference type="SMR" id="Q5APE0"/>
    <dbReference type="STRING" id="237561.Q5APE0"/>
    <dbReference type="GeneID" id="3634892"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109620CA"/>
    <dbReference type="CGD" id="CAL0000192723">
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    <dbReference type="HOGENOM" id="CLU_128881_1_0_1"/>
    <dbReference type="InParanoid" id="Q5APE0"/>
    <dbReference type="OMA" id="HRVGFEL"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000192723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW26594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17894" checksum="B84382875C2E2D46" modified="2005-04-26" version="1">MSIFTKQFPNLKQLQKNITQELLKYENSTARSLSKAELEKTRTYYNYLKKVKLSKGEISAIKDIDTKLADLSKDKFQHQAELQNKNSLNGITENITNEKLPHEYKLNNLNNVHQYLKNQREYFELLTRYNPGLLMSQADNVSKTANKVGLEVPN</sequence>
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<entry dataset="Swiss-Prot" created="2003-11-21" modified="2025-02-05" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q9P4E6</accession>
    <accession>A0A1D8PR77</accession>
    <accession>Q5A5A8</accession>
    <name>LIP9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase 9</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP9</name>
        <name type="ordered locus">CAALFM_C702880CA</name>
        <name type="ORF">CaO19.12639</name>
        <name type="ORF">CaO19.5172</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
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            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Arch. Microbiol." volume="174" first="362" last="374">
            <title>Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members.</title>
            <authorList>
                <person name="Hube B."/>
                <person name="Stehr F."/>
                <person name="Bossenz M."/>
                <person name="Mazur A."/>
                <person name="Kretschmar M."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="11131027"/>
            <dbReference type="DOI" id="10.1007/s002030000218"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="4" first="401" last="408">
            <title>Expression analysis of the Candida albicans lipase gene family during experimental infections and in patient samples.</title>
            <authorList>
                <person name="Stehr F."/>
                <person name="Felk A."/>
                <person name="Gacser A."/>
                <person name="Kretschmar M."/>
                <person name="Maehnss B."/>
                <person name="Neuber K."/>
                <person name="Hube B."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="14734020"/>
            <dbReference type="DOI" id="10.1016/s1567-1356(03)00205-8"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="FEMS Microbiol. Lett." volume="244" first="359" last="365">
            <title>Differential Candida albicans lipase gene expression during alimentary tract colonization and infection.</title>
            <authorList>
                <person name="Schofield D.A."/>
                <person name="Westwater C."/>
                <person name="Warner T."/>
                <person name="Balish E."/>
            </authorList>
            <dbReference type="PubMed" id="15766791"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2005.02.015"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 8">Secreted lipase that is able to hydrolyze both the neutral triacylglycerols and the monopalmitate ester Tween 40, allowing the use of hydrolyzed products as carbon sources (PubMed:11131027). Has broad lipolytic activity, which may be important for colonization and subsequent infection, therefore contributing to the persistence and virulence in human tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Expression is not induced in medium containing Tween 40 as the sole source of carbon (PubMed:11131027). Expression is up-regulated during the yeast-to-hyphal transition (PubMed:11131027). Expressed during experimental infection of mice (PubMed:11131027). During host infection, expressed in gastric tissues, but not in infected oral tissues (PubMed:15766791).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AF191322">
        <property type="protein sequence ID" value="AAF79929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716995.2">
        <property type="nucleotide sequence ID" value="XM_711902.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9P4E6"/>
    <dbReference type="SMR" id="Q9P4E6"/>
    <dbReference type="STRING" id="237561.Q9P4E6"/>
    <dbReference type="ESTHER" id="canal-LIP9">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
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        <property type="glycosylation" value="5 sites, No reported glycans"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="Lipase_secreted"/>
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    <keyword id="KW-0964">Secreted</keyword>
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    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
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    <feature type="chain" id="PRO_0000017828" description="Lipase 9">
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            <begin position="15"/>
            <end position="453"/>
        </location>
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            <position position="36"/>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="43"/>
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        <source>
            <dbReference type="CGD" id="CAL0000194446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW25727.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="43" mass="4900" checksum="A7192F2A0A431116" modified="2017-01-18" version="1" fragment="single">DMGNNDRVVIQDLLKDVASTEQVDFANQSRAKHRFKIVIINEA</sequence>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
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        <text evidence="1 5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS21B is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits and has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
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        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
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        <source>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="87" mass="9639" checksum="E744C3540B02A11C" modified="2017-01-18" version="1">MENDKGQLVELYVPRKCSATNRIIKAKDHASVQISIAKVDEDGRAIAGENITYALSGYVRGRGEADDSLNRLAQQDGLLKNVWSYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PDY5_CANAL</name>
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        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
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        <name evidence="2" type="ordered locus">orf19.13600</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="3639525"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106920CA"/>
    <dbReference type="CGD" id="CAL0000178470">
        <property type="gene designation" value="orf19.13600"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06920C_A"/>
    <dbReference type="eggNOG" id="KOG1398">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
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        <location>
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        <location>
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            <end position="429"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26346.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50955" checksum="76E7F03194FAB428" modified="2017-01-18" version="1">MSSLTSEMLKNSQQHRRVTRHLLNNIAKPSLRAFLYAYLYLVLPKAIGQILSAIRKNKYDKIIPRVKKTMINALHPRKFPMFAASLVAGINLLEPMFLKLLKRNNRLAKSPTSRVFVSTLLAALISAIVTFPTYQTHVLGYGRYNSLDLTLLVATRALDTTLSSSLSKITPSSLSDYGDALLFIASCTCIMFCWFFYPEKLPPSYHKWITSAANMDIEFWEILRLVQQKKLVYGEHGPYEDYLGPYFEKHGRDPKRGNTVLTQPIECEAVHAFTTKSCELHALWRFWRGFKFAIGVYAPLNLLMLIFPSKVKMSARLFRAIKSSIRSASFLGAFIGFYWYAVCLARTRLLPKLFPKIPRVRFDDTICAASGAFMCGFSSFIETPQRRKELALFVAPRGLGTLVPSEPTKKNLAIESIVFSIGLAVLVAYSKNRASSVRGIFGKGLKQVFVI</sequence>
</entry>
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    <accession>A0A1D8PFS4</accession>
    <name>A0A1D8PFS4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">GND1</name>
        <name evidence="17" type="ordered locus">CAALFM_C113860CA</name>
        <name evidence="16" type="ordered locus">orf19.12491</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330729.1">
        <property type="nucleotide sequence ID" value="XM_019475184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFS4"/>
    <dbReference type="SMR" id="A0A1D8PFS4"/>
    <dbReference type="FunCoup" id="A0A1D8PFS4">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFS4"/>
    <dbReference type="GeneID" id="3636131"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113860CA"/>
    <dbReference type="CGD" id="CAL0000188008">
        <property type="gene designation" value="GND1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13860C_A"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFS4"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:D-gluconate metabolic process"/>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
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    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
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        <location>
            <begin position="182"/>
            <end position="482"/>
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        <location>
            <begin position="13"/>
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            <begin position="78"/>
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        <location>
            <position position="106"/>
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        <ligand>
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        </source>
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        <source>
            <dbReference type="EMBL" id="AOW26988.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="495" mass="54374" checksum="D1A467AD32C77658" modified="2017-01-18" version="1">MSSAPKGDIGLIGLAVMGQNLILNMADHGYTVVAYNRTTAKVDRFLENEAKGKSILGAHSIKELVDQLKRPRRIMLLVKAGAPVDEFINQLLPYLEEGDIIIDGGNSHFPDSNRRYEELAKKGILFVGSGVSGGEEGARTGPSLMPGGNEKAWPHIKDIFQDVAAKSDGEPCCDWVGDAGAGHYVKMVHNGIEYGDMQLICEAYDLMKRVGKFEDKEIGDVFATWNKGVLDSFLIEITRDILYYNDPTDGKPLVEKILDTAGQKGTGKWTAVNALDLGIPVTLIGEAVFSRCLSAMKAERVEASKALKGPQVTGESPITDKKQFIDDLEQALYASKIISYTQGFMLMNQAAKDYGWKLNNAGIALMWRGGCIIRSVFLAEITAAYRKKPDLENLLLYPFFNDAITKAQSGWRASVGKAIQYGIPTPAFSTALAFYDGLRSERLPANLLQAQRDYFGAHTFKVLPGQENELLKKDEWIHINWTGRGGDVSSTTYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG13</accession>
    <name>A0A1D8PG13_CANAL</name>
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        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C200220CA</name>
        <name evidence="13" type="ordered locus">orf19.9659</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_714464.2"/>
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    </dbReference>
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        <property type="gene designation" value="orf19.9659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00220C_A"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="26094at2759"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIF_beta"/>
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        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
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        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
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        <property type="entry name" value="TFIIF_interaction"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="59"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
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            <end position="381"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000197597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="381" mass="44160" checksum="C5604596E0431826" modified="2017-01-18" version="1">MSSIKTSPTKKTSESTTKQDTPNDQTNIENFDEEPSMLSDPEDYLEENETLDMNLSKGDQKVWLVKLPKYLMDDWSNPDSMNGQQLGNVKIKKDARGKLQVKLLLDNKNDRIPKEYDIKMLNTQVRNSYVFTEENLKKFKQEVTEVSDMPEQPQLKELNPEKKKFQVRRKFKYFRVQKEGENGQPVKKYIPFVKTIPKKTSLMGKVCHDCTVVPARTGSKHGESLMKHQNMTQGKERPKVTLLNEIPGVIQSNAGPSIKGNAASIFLKSTQGKNKSEGRAIRMPKKDLLDLLFRLFEEYEYWSMKGLKERTRQPESYLKESLESIATLIKRGPYTSKYTLKAEYRRLRDAERAVRLGLDEDDQNKENNEDEDEDEEMEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGP5</accession>
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        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="primary">SDH8</name>
        <name evidence="5" type="ordered locus">CAALFM_C202620WA</name>
        <name evidence="4" type="ordered locus">orf19.9161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGP5"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C202620WA"/>
    <dbReference type="CGD" id="CAL0000192813">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02620W_A"/>
    <dbReference type="eggNOG" id="ENOG502S6UN">
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    <dbReference type="Proteomes" id="UP000000559">
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    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000192813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="139" mass="15586" checksum="29BD8E0FDE9FB82D" modified="2017-01-18" version="1">MSTMLARIFKQSSTLCPLRVGTSSIRFFSPPSKFDFQPGPPRLPKEQQEEFEKLQSIANSQIAIEEYNDQIAQQQAEGSTQEPKAPIVNSEIGSFSSLKLVPDFEGEVNPKTGERGGPKQEPLKHTKDEWSFNGRVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH17</accession>
    <name>A0A1D8PH17_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">VMA7</name>
        <name evidence="13" type="ordered locus">CAALFM_C204150CA</name>
        <name evidence="12" type="ordered locus">orf19.8424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720930.2">
        <property type="nucleotide sequence ID" value="XM_715837.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH17"/>
    <dbReference type="SMR" id="A0A1D8PH17"/>
    <dbReference type="FunCoup" id="A0A1D8PH17">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH17"/>
    <dbReference type="GeneID" id="3637332"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204150CA"/>
    <dbReference type="CGD" id="CAL0000194906">
        <property type="gene designation" value="VMA7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04150C_A"/>
    <dbReference type="eggNOG" id="KOG3432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH17"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900434">
        <property type="term" value="P:regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
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        <source>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="334" first="1149" last="1158">
            <title>Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro.</title>
            <authorList>
                <person name="Singh V."/>
                <person name="Sinha I."/>
                <person name="Sadhale P.P."/>
            </authorList>
            <dbReference type="PubMed" id="16039996"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.07.018"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Proteomics" volume="9" first="4770" last="4786">
            <title>Analysis of Candida albicans plasma membrane proteome.</title>
            <authorList>
                <person name="Cabezon V."/>
                <person name="Llama-Palacios A."/>
                <person name="Nombela C."/>
                <person name="Monteoliva L."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="19824013"/>
            <dbReference type="DOI" id="10.1002/pmic.200800988"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
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            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
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        <scope>INDUCTION</scope>
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    <reference key="7">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2023" name="Front. Cell. Infect. Microbiol." volume="13" first="1136698" last="1136698">
            <title>QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches.</title>
            <authorList>
                <person name="Zeng L."/>
                <person name="Huang Y."/>
                <person name="Tan J."/>
                <person name="Peng J."/>
                <person name="Hu N."/>
                <person name="Liu Q."/>
                <person name="Cao Y."/>
                <person name="Zhang Y."/>
                <person name="Chen J."/>
                <person name="Huang X."/>
            </authorList>
            <dbReference type="PubMed" id="36923588"/>
            <dbReference type="DOI" id="10.3389/fcimb.2023.1136698"/>
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        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="13 14 15" key="9">
        <citation type="journal article" date="2022" name="Structure" volume="30" first="129" last="138.e4">
            <title>Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.</title>
            <authorList>
                <person name="Di Trani J.M."/>
                <person name="Liu Z."/>
                <person name="Whitesell L."/>
                <person name="Brzezinski P."/>
                <person name="Cowen L.E."/>
                <person name="Rubinstein J.L."/>
            </authorList>
            <dbReference type="PubMed" id="34525326"/>
            <dbReference type="DOI" id="10.1016/j.str.2021.08.006"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS) OF THE HOMODIMERIC RESPIRATORY COMPLEX III</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34525326, PubMed:36923588). The complex plays an important role in the uptake of multiple carbon sources present in different host niches (PubMed:36923588).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 5 6">Expression is up-regulated in cells that undergo morphogenesis to form pseudohyphal cells when co-incubated with macrophages (PubMed:16039996). The promoter contains the conserved motif 5'-TGAAAA(G/T)GAAG-3' found in morphogenesis up-regulated genes involved in energy generation including ATP2, ATP3, ATP4, ATP20, QCR8, COX4, and SDH1 (PubMed:16039996). Expression is repressed during formation os spider biofilm (PubMed:34525326). Expression is repressed by HAP43 (PubMed:21592964).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Leads to decreased vegetative growth on several carbon sources including maltose, citrate and acetate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330771.1">
        <property type="nucleotide sequence ID" value="XM_019475226.1"/>
    </dbReference>
    <dbReference type="PDB" id="7RJA">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="F/P=1-95"/>
    </dbReference>
    <dbReference type="PDB" id="7RJB">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="F=1-95"/>
    </dbReference>
    <dbReference type="PDB" id="7RJC">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="F=1-95"/>
    </dbReference>
    <dbReference type="PDB" id="7RJD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="F=1-95"/>
    </dbReference>
    <dbReference type="PDB" id="7RJE">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="F/O=1-95"/>
    </dbReference>
    <dbReference type="PDBsum" id="7RJA"/>
    <dbReference type="PDBsum" id="7RJB"/>
    <dbReference type="PDBsum" id="7RJC"/>
    <dbReference type="PDBsum" id="7RJD"/>
    <dbReference type="PDBsum" id="7RJE"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHA2"/>
    <dbReference type="EMDB" id="EMD-24482"/>
    <dbReference type="EMDB" id="EMD-24483"/>
    <dbReference type="EMDB" id="EMD-24484"/>
    <dbReference type="EMDB" id="EMD-24485"/>
    <dbReference type="EMDB" id="EMD-24486"/>
    <dbReference type="SMR" id="A0A1D8PHA2"/>
    <dbReference type="FunCoup" id="A0A1D8PHA2">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHA2"/>
    <dbReference type="EnsemblFungi" id="C2_04590C_A-T">
        <property type="protein sequence ID" value="C2_04590C_A-T-p1"/>
        <property type="gene ID" value="C2_04590C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515112"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204590CA"/>
    <dbReference type="CGD" id="CAL0000201360">
        <property type="gene designation" value="QCR8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04590C_A"/>
    <dbReference type="eggNOG" id="KOG4116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHA2"/>
    <dbReference type="OMA" id="QWAIERN"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000459232" description="Cytochrome b-c1 complex subunit 8, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="strand" evidence="16">
        <location>
            <begin position="24"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="helix" evidence="17">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="turn" evidence="16">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="helix" evidence="16">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="turn" evidence="16">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="helix" evidence="16">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P08525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16039996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19824013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="34525326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="36923588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="34525326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="36923588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="13">
        <source>
            <dbReference type="PDB" id="7RJA"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="14">
        <source>
            <dbReference type="PDB" id="7RJB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="7RJC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="7RJA"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="7RJE"/>
        </source>
    </evidence>
    <sequence length="95" mass="11112" checksum="57AA587A0A587962" modified="2017-01-18" version="1">MAGAPHPHTYMGWWGSLGSPKQKYITQYTISPYAAKPLKGAAYNAVFNTFRRTKNQFLYVAIPFVVVWSIWTRARDYNEYLYTKEGREELERVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHD2</accession>
    <name>A0A1D8PHD2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">CDC7</name>
        <name evidence="10" type="ordered locus">CAALFM_C205320WA</name>
        <name evidence="9" type="ordered locus">orf19.11045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714920.1">
        <property type="nucleotide sequence ID" value="XM_709827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHD2"/>
    <dbReference type="SMR" id="A0A1D8PHD2"/>
    <dbReference type="FunCoup" id="A0A1D8PHD2">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHD2"/>
    <dbReference type="GeneID" id="3643424"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205320WA"/>
    <dbReference type="CGD" id="CAL0000191207">
        <property type="gene designation" value="CDC7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05320W_A"/>
    <dbReference type="eggNOG" id="KOG1167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHD2"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905263">
        <property type="term" value="P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905342">
        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904968">
        <property type="term" value="P:positive regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000637">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="173"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000191207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="656" mass="74963" checksum="A5BA93CBFBEDD41A" modified="2017-01-18" version="1">MQEVLFTYHQRSDQPPPPPSQQSHLHASTPTPTPLSNMKRKQSSESDDPFKDRSCKSRKDASTANLLRLQQSLSNSTFIRNSNLSKSYKHNETTEVANNNLHDTTFSQTTETEEFVTPNQLDEQLEVAGRGGRGVVVEEEQREEEEEEEEVTLEVLENMQKLETNFPILATDYRLIDKIGEGTFSTVYKAESLTGKIRLGSDIWKSPPLKRNKRNILNFQQSRKKNPIVALKQIYVTSSPNRIFNELHLLYMLSGNSRVAPLLDVLRFQDQIVAILPYYNHCDFREFYRDLPVKGIKKYLWELFQALDYIHGKGVIHRDLKPTNFLYDPFRGKGVLVDFGLAERENISKNTKPETSTTSSSGTATTTTTATTTTTTTTTTTTNSSTASSSAISTACPCLNKDQKLINRTHTKRLNVKGAYPKNDNRPPRRANRAGTRGFRAPEVLFKCTNQSTKIDIWSAGIIGFSILLRKFPIFNSPTDTDAILELAWIFGYDKMAKCAELHGCGLEISMPEIHKSNGNLIKIMYDFLMQEHINGCFPSDSVVYDTLELINESGEKFVKPVYTIREGISDIEKMKINEDFTKRHDDYKDHKYLMELLYGCFKMDPSKRLSAREILQLPFFHEILQISEDDTQDEFMQQNQTQTQEEEEEDEVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHK2</accession>
    <name>A0A1D8PHK2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C205960CA</name>
        <name evidence="5" type="ordered locus">orf19.12683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710924.2">
        <property type="nucleotide sequence ID" value="XM_705832.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHK2"/>
    <dbReference type="SMR" id="A0A1D8PHK2"/>
    <dbReference type="FunCoup" id="A0A1D8PHK2">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHK2"/>
    <dbReference type="GeneID" id="3647479"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205960CA"/>
    <dbReference type="CGD" id="CAL0000186313">
        <property type="gene designation" value="orf19.12683"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05960C_A"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHK2"/>
    <dbReference type="OMA" id="PTGERAF"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000004">
        <property type="entry name" value="Acyl-CoA thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase 2 C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000186313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="298" mass="33907" checksum="263302A938B398AF" modified="2017-01-18" version="1">MTDLTTVHQLPYVDIASVFDVKQIETYRYRGIKPLQKQSSQHRGVFGGNFVAQSLLVAIRSAPHGFQPHTIHSYFVRAGDDKTPIEWEVDEITNGRTFANRAIRGFQNGKVVFTANVSLTSKNSVKDIVKKTGTTPVIFQKEVETEYQDLKNNISKCPLFVENSNAHFTVRTFPINLSSDIYAFLSKFGAESKETVVGLTTEYQYVALATISDFVRLEEVFKIMGVEVDVSFNVSLDHSIYFHDNDFDATKWSTYLVEVTRWSHDRVMIVGKIYNDKGIHVASISQERLFVIKNKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI74</accession>
    <name>A0A1D8PI74_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Stress response RCI peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C208700CA</name>
        <name evidence="9" type="ordered locus">orf19.11089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="CGD" id="CAL0000189509"/>
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        <source>
            <dbReference type="EMBL" id="AOW27822.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    <reference evidence="6 7" key="1">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
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        <property type="protein sequence ID" value="AOW27831.1"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="HhH-GPD_domain"/>
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    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ALKYLBASE_DNA_GLYCOS"/>
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    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="150"/>
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    </evidence>
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    </evidence>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Dungan J."/>
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    <reference evidence="2 3" key="2">
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                <person name="Martchenko M."/>
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        </source>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2021-07" db="PDB data bank">
            <title>Crystal structure of ARF3 from Candida albicans in complex with guanosine-3'-monophosphate-5'-diphosphate.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
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        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
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    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="27"/>
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        <ligand>
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        <location>
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        <ligand>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="7RLL"/>
        </source>
    </evidence>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_716621.2"/>
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    <dbReference type="SMR" id="A0A1D8PJC7"/>
    <dbReference type="STRING" id="237561.A0A1D8PJC7"/>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="58" mass="6733" checksum="B9C465B8D64F7ADE" modified="2017-01-18" version="1">MSTKHTQELENLRKLRATLEAIKESTAKMLQDITTIYKDNNPQLLQNSKDFQKALNDL</sequence>
</entry>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_716607.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PJG1"/>
    <dbReference type="FunCoup" id="A0A1D8PJG1">
        <property type="interactions" value="353"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0082">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Candida</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E26962" last="E26962">
            <title>In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription factors mutants for mice organ colonization.</title>
            <authorList>
                <person name="Vandeputte P."/>
                <person name="Ischer F."/>
                <person name="Sanglard D."/>
                <person name="Coste A.T."/>
            </authorList>
            <dbReference type="PubMed" id="22073120"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0026962"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
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            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2017" name="Genetics" volume="205" first="559" last="576">
            <title>Zinc Cluster Transcription Factors Alter Virulence in Candida albicans.</title>
            <authorList>
                <person name="Issi L."/>
                <person name="Farrer R.A."/>
                <person name="Pastor K."/>
                <person name="Landry B."/>
                <person name="Delorey T."/>
                <person name="Bell G.W."/>
                <person name="Thompson D.A."/>
                <person name="Cuomo C.A."/>
                <person name="Rao R.P."/>
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            <dbReference type="PubMed" id="27932543"/>
            <dbReference type="DOI" id="10.1534/genetics.116.195024"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor required for full virulence.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 5 6">Expression is negatively reguled by the ZCFs master regulator of ZCF29 (PubMed:27932543). Expression is induced during biofilm formation (PubMed:21414038, PubMed:22265407).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to a decreased colonization in a systemic mice kidney infection model.</text>
    </comment>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <keyword id="KW-0238">DNA-binding</keyword>
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            <begin position="1"/>
            <end position="838"/>
        </location>
    </feature>
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            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
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    </evidence>
    <sequence length="838" mass="95122" checksum="21B78D5A102ADC01" modified="2017-01-18" version="1">MSSALLPISCISCRKRKIKCNRIKPCDQCIKRHLPCEFPEKFRNIKIQEDEIKPELDGEPKLEPEDDMNSIYDYTRKPSENSSISTSGSASILSSAPSKSTDSTDSIPTSTDSATNSDSREKCMVTKNHSTGKISHSSPSAIPITVGSLNNSIISSSKNLIDSDAPNQDSDNLTLLRDDYDIMKAANTQLLSSNRLLKRQLEELQQSTLSHFRRSDMRNCHDNAHKNGSCSCNKTTKTIDNGNHNRGDANANLLPNLPRSGDKRANTSDSFSDESPNKKEKVGVFGYSKSSFPKDSASQNQGIYSNNQFNEDNSSSPPKETSTTSTDSSSSGGEIGQTLTFQPLSKEQRELLNGRKVHRVKRNRGQGFYEHQVSSQPPVNKNGLPNRSVNHNHNWEQDAETYQDQESIKSSIQIQKSLKKKTLPILPSYLLKYDDPGISVDSTTYQDISRLNFEVVVKLVEKFFENNSYYRTFISSVHVFDFLNGYNSINDRDWENDDDLLLVYMILCLSIERLSPQDFVELNLLPDGSLNICTKYRKFLTRQVLYKSFERLKENLVDESMITIQTYILCSEWLFLQQNYEECWQMMFHACSISFSIGLHIMNQFRATNTKENKPFKNVVDATMGESDSSSEKKDTMELEEDKKNEDEELNAQQYRLWYALKYSTSVICSIFGRPNPISVKVGMIDSTPLNQIDQKLHVLLKSESSESLRLSNLMLIENYMIDISFENVMTLKLKFDTDILTLEDSYDSIHGKITCSLIGGSEQQNKSNDNANKWIGYDDYTKGSLTTKELDVLSDTIILHINSVKLLEPFVKKYETQKGKDTLSEKQIDSIGXFYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJJ8</accession>
    <name>A0A1D8PJJ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">APL5</name>
        <name evidence="11" type="ordered locus">CAALFM_C302590WA</name>
        <name evidence="10" type="ordered locus">orf19.7879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719947.2">
        <property type="nucleotide sequence ID" value="XM_714854.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJJ8"/>
    <dbReference type="SMR" id="A0A1D8PJJ8"/>
    <dbReference type="FunCoup" id="A0A1D8PJJ8">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJJ8"/>
    <dbReference type="GeneID" id="3638377"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302590WA"/>
    <dbReference type="CGD" id="CAL0000194310">
        <property type="gene designation" value="APL5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02590W_A"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJJ8"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="911"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000194310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1099" mass="125186" checksum="FCEFDC7DDD950132" modified="2017-01-18" version="1">MSSFQLQNSEVLARLKPFGISFEKSLNDLIKGIRAHTKESPESLGNFLDVAIQECRNELTTTDLETKAMAILKLAYLEMYGFDMSWCNFQILEVMSSSKFQQKRIGYLAAIQSFKNEQDLLILATNQFKKDLNSHNHVDIGLALSGIATIVTPSLAKDINDDVLMKLNHSKPYIRKKAILAMYKIFLQYPESLRLNFNRVIEKLDDSEIAVVSATVNVICEISKKNPNIFINYLPKFFAILEDTKNNWLIIRILKLFQSLSKVEPRMKKKILPTIIDLMLRTQASSLIYECINCIVSGQMLSADSSKDKETAKLCINQLKLFFLTNDSNLKFVGLIALINTLKIFPILINDVEGISEIVLECLNDRDLIIKRKALEVSNYLVNEDNITEVVKIMLMQLVPDNNMIDDMLKLEITLKILQIASQNNYVNIPNFRWYVAVLKDVINLTLLPVEGATNSGLIASHIANEISTEVGKEFKNLATKVPSVRSYLLQNVVLELVQDVRLLDSSALILKDLYWILGEYISELKVTQNDDGDDDSDSDSDGEDAQVMVLDIDKKIKVFNTLINYQIDKKLGLTSNIHFPVSAKLINLHFTSVVAVLIQALVKLYNGIATDYINNFATTNGQLPLEKYHELCYHLYRLIGFLSNWENHPNYEVQERALSWLEFLKLILEAMTDNDFTDIKKLEESDLKMYKDLPIAKGGDSESESESESEDDDEEEEEEEEENDYSEDDSESEDDGYENLVSSDEEGNSKPSKSTLPIQEEEYNPFAENEESESKNLTGGNEAEEETQEQENQQEDDNGMKQLPMLLTHVLPSFFTAYTLNPVAKNAQRNVGVPEDLDLNTQIHSPDFKLEQFDDDSSDSYELYLSEVEDMEPLIHLSSDEPQEKKKERLERLKDDPYYLDDDAVVKTKKKSKSKKIKSESISPDVESENASITNTIVSETDTDMNKKKKQTKKKKTNKLKKEKVLILDEETIVGESNITTPIESTQIQTHKEKKKPTKKNTFKIDSSNLDNFDLVSNDSETQLHNDKEYEIDLEALREKLKKTTVEPKIKDKEAKSKKKSKKSKKTSEEGKSTTTESNGVEPLKPKKVKKKKAIILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJL2</accession>
    <name>A0A1D8PJL2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C303150WA</name>
        <name evidence="3" type="ordered locus">orf19.7946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720009.2">
        <property type="nucleotide sequence ID" value="XM_714916.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJL2"/>
    <dbReference type="SMR" id="A0A1D8PJL2"/>
    <dbReference type="FunCoup" id="A0A1D8PJL2">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJL2"/>
    <dbReference type="GeneID" id="3638423"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303150WA"/>
    <dbReference type="CGD" id="CAL0000187518">
        <property type="gene designation" value="orf19.7946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03150W_A"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJL2"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="STB6-like N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000187518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="999" mass="114109" checksum="E5F2711FE85F9B8B" modified="2017-01-18" version="1">MSSPLNSPYSRFNQGLNYNSRSSNQLVYGESSSLNGSVDSNVLRVNSGSNSNPNDFITYIIPDFDAVTYFQKDFQALNEFHLCEESEASGFEIYLVEQWMNDRNISSVVTTFTGNESSKISVVRFTILKKPAKYYPLRFQEYLNELIQNHSRMKRIEKEKPTYQHSRTNSNSEMLTLSKLSTTSIPKRESSSDYTSEVCFVANLTSLPSNLNLIPVPGGDSRKVSTAFMINSNLKKLQCTGRSVSMITSKISDASDDKFRQMYKIQSTKVPIVFAAKELVNIVQTCLFYFDLLDAKYCNGLLCTKTEEAITNWWNLIGLPHFSVKPNPVNGILPSRTVAAIVSLILSVRMRIQLVGSSDVPKDPFDFENFMIAIGQFQRQYKLDKTRKLDMETLNKLFTVTNARLLPQKNTNYFYSQVSTGSDLDPQSFDIISQSGNPKGLDSTSQKRRYGKELKKLTNVMKSSVSDRINAASVRDIDDMSAPSKASSGRIRNKIAKLADTVSPLDVETLDLEFLVKKHLNGKTLIRLFYGTQSSNTFLSVEKSSDPQNKGHRHNLVNTHNSHLAFPKRRGRTMVENSSTLQYKFESLRDKIAQTQELVMINDPSRYSRGLNRMKLGLQSKKNPLTGGEKNSMLLTPGGNYYSSPMQTASLVDSFLQISNDDASGVESVCSKPNSINRRCVNSVFDFKHPLASFKHNLNRRNSFPYLENQHEQNLNTLVIAKNQSGINFEEIDLLKRKRSISFSCVEDAVLSGKVQAIGSMTKFSQSFLDSIRVLMKYESLKSYYLEGEKKEKHVTNQQLNKSYQLMNLELIKMKNLRNQMDAHQSRIMEGGIEEELHYSMKTLNTTIDRLVYETRIVAKRIDELEQDFKLYEMKLNDECKSKLTEIIDKVLHSKQFKEVFTSPEERKQIAYKLTGDENYIKFDDEKESIGLLRMIVMFFYGIISSIFRFFHFNRDNMNLERIRQAWVILDPNRSIIKHAYSYIGREPSKDSIASTDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJR2</accession>
    <name>A0A1D8PJR2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">GTT11</name>
        <name evidence="8" type="ordered locus">CAALFM_C303720WA</name>
        <name evidence="7" type="ordered locus">orf19.14209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330853.1">
        <property type="nucleotide sequence ID" value="XM_019475308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJR2"/>
    <dbReference type="SMR" id="A0A1D8PJR2"/>
    <dbReference type="FunCoup" id="A0A1D8PJR2">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJR2"/>
    <dbReference type="GeneID" id="3645644"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303720WA"/>
    <dbReference type="CGD" id="CAL0000194770">
        <property type="gene designation" value="GTT11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03720W_A"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJR2"/>
    <dbReference type="OMA" id="WIHFAES"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000194770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="249" mass="28654" checksum="DCD49A2543777ED3" modified="2017-01-18" version="1">MSDTKIIVHWLNYSRSQRVIWLLEELNIPFELKVYLRNKQFRAPKELENVHPLGKSPVIEVIDTKTGESEVIAETGHIFNYILSNYDTTNILTPANRKLQNQVDYFLHYAEGTLQPNLVALLVHGFAKQQAPFGTKFLMGLLVNGIDSMFYIPELKKNLNYLEDIMRKQHENGSNYFVGDKLSGADIILEFPVITNIFQNKRGAEQLGAGDVEKEYPHLNQWAEDIKKEPKYIKAQELVAKHETVKPNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK40</accession>
    <name>RL19A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L19-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL19A</name>
        <name type="synonym">RPL19B</name>
        <name type="ordered locus">orf19.5904</name>
        <name type="ORF">CAALFM_C304500CA</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPL19A may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330865.1">
        <property type="nucleotide sequence ID" value="XM_019475320.1"/>
    </dbReference>
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    <sequence length="190" mass="21885" checksum="B132BF6A2C3ED1D6" modified="2017-01-18" version="1">MANLRTQKRLAASVIGVGKRKVWLDPNETTEIANANSRSAIRKLYKNGTIVKKPETVHSRSRARALKESKRAGRHMGYGKRKGTKDARMPSQVLWMRRLRVLRKLLAKYRDAGKIDKHLYHNLYKAAKGNTFKHKRSLVEHIIAAKAEALREKALKEEAEARRVRNRAARERRQQRLAEKKEALFAEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK68</accession>
    <name>A0A1D8PK68_CANAL</name>
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            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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        <name evidence="8" type="ordered locus">CAALFM_C305380WA</name>
        <name evidence="7" type="ordered locus">orf19.6976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000179271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67871" checksum="E26C114DBEAD57C5" modified="2017-01-18" version="1">MTSVEPDIESEALLEIAANDAYQAIIEEEEEDVDEANSSQDEDVIWLREQIENNKAISWINRPSVYILGLVICIFMIAFASTIGVKQIILFKLACNTVANSKGYCDPIETQVLVSSYEMYSMVGGTLVSLIPVAKAGELSDIYGRKPFFIAMFVSATTSHLCSYLIFHHYNTFPFKLLLGAQWISSICGGMIMVPALIGSYISDIVESQGRIYALGLGMSSLFIGQSLGPMFGNWINSIGKHLNQEQKEKIGIRAITTLSSILPSEFFLLKIEIIIDIIICIYVITLFPESRNAKARAKSRANSITSSRSSNSNSNSNSSTRGGVGVFIGTAGDAVDQLQELNNQQQSSSKSKLSMFFNIFSPLVILTYPTNLINENGKHRASQYRFVVISLIISQCINMMMIMTLGQILIQYGIFVFDWSSEDVGNLLTVLASTRAIILIVILPIFQNKILKKKFKFRVLKKQLDMIDYSLMLIGYSVDFIFLILLVYTKSTTQVLTLGAFYSIGSIAHPTTQSTLLKFYPTSKIGVVFGANTLLHNIVGVVAPVMIMNFYSKTLKNGWPGAVFILYSLLVLIIIILVVVSKRVLKLNVNTTDERLIRSNSSVSLSRSNAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKC6</accession>
    <name>A0A1D8PKC6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ase1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ASE1</name>
        <name evidence="4" type="ordered locus">CAALFM_C305960WA</name>
        <name evidence="3" type="ordered locus">orf19.7377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716618.1">
        <property type="nucleotide sequence ID" value="XM_711525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKC6"/>
    <dbReference type="SMR" id="A0A1D8PKC6"/>
    <dbReference type="FunCoup" id="A0A1D8PKC6">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKC6"/>
    <dbReference type="GeneID" id="3641729"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305960WA"/>
    <dbReference type="CGD" id="CAL0000187724">
        <property type="gene designation" value="ASE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05960W_A"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKC6"/>
    <dbReference type="OMA" id="KRITRHF"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000187724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="906" mass="104864" checksum="F66C9A43C3C202FF" modified="2017-01-18" version="1">MITDILPRSSPIHQTQSAPVYSKLSNSLHSTPTKQSTISPSLDRPMPMDHPIQEDELGDSTTEVDSEESNQNNSRNKNHQQFESIAHNINETISELNIIYQEIGYSLLETNNKKSKIFNTIQDTIKNFANNLNREKSNIENECEWLRQQIRIILSMINDPRGDKSLELICKGLVFNNQQQYEDGYREQILNKITAMSDEFKSGSLSMEQQYDYMMKNIPKLSLIEQRNRLNKIFLQVLKSFVITFKKLNQVNLDYVEVCDIIGDENIPKSSVLLTLPSKSDAEYHRYVIDEFERIIQALNFSDSNQIPTDHRKEKFTAFVLASPVKKNQESSESGNDGFVKLRDINYQLVRIIRGLRFTKITNELISNIKYEIEQCQAEIETRKSTVIGIIEKCIQLINVLQLNDDQILQLQKEHNPHIEALLDMETLNLILQEPQQLGLNDSHIEFLISFQNMLQETIDTKQAQWDQYSATCKSLWEKLGESDEYITNFLSKNNSLTDLSLLNFKMELNRLYIKRSEYIESFISDARTEIEKMWDKMYYSQDMRMDFEFFNYSGENDDIDKEVVLSKHEEELENLKQEYAQKKNLFQMYEELQELLKDQQFLIESSKDSSRLLSKNSCKILLNEEKIRKRINKTLPKLIDNLKKETSQYNNDAIQMGKRTLFINGEDFFEKILFIESEQFKISGGRSKSSSRVSSRQVSQSKTVAPTRQPSRGSHQHKSPIKVMSRPASRSIINKNPSPVSRTTSRWNKERTFNNPTTIKLSNAINSRLENNHNRHQQLHLHHQNTSILSEESPVRASRDNSVLGKPPATIQPLISPLKPLNVHTVGNTNLNGTPLSRTKPESTNVSYGKENCSPFELSPVKIRPGFFDHDGSRRVSGISNDTSTVIGEDYLSWRDEKIKQLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKI4</accession>
    <name>A0A1D8PKI4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TFIIH complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C306550CA</name>
        <name evidence="2" type="ordered locus">orf19.7444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716105.1">
        <property type="nucleotide sequence ID" value="XM_711012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKI4"/>
    <dbReference type="FunCoup" id="A0A1D8PKI4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKI4"/>
    <dbReference type="GeneID" id="3642275"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306550CA"/>
    <dbReference type="CGD" id="CAL0000188264">
        <property type="gene designation" value="orf19.7444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06550C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PKI4"/>
    <dbReference type="OMA" id="DFIWYSI"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000188264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="341" mass="39179" checksum="D82B90409D518ECB" modified="2017-01-18" version="1">MNIDNTNDISSPPTPIHPAPNEELTNGVPTNTLLADSNIDLNPDLYEEEEMDIEEAKSNIVDEIPPENLTSNDPALQPQTGNAFNDNINDATTNADSDLEDVEINQLHQITLPFNESYQLLKQEFQNTLTNLGQSQITSAQQSKLINYIDETLLQIQRKFIKQQTESEINYSLIQLLQELSTVISVIWVSIQQKSVLYGQIEYYIKILGDLEDYVNNYKTLFNETWSKNNNLHINMQNLVIFFKFWQKIDLQLSFLIDGYNIVLNNGNQQTKLIKMNVTELTRLLPIVTRLRIAIISKIDGLRMRLKKNQENNNDNDATSNILTIFELEISRLFEGILERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06690C_A"/>
    <dbReference type="eggNOG" id="ENOG502TI9N">
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    <dbReference type="InParanoid" id="A0A1D8PKK2"/>
    <dbReference type="OMA" id="MKAPQNG"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
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        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000183051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="121" mass="13063" checksum="CBD6768BD4863B10" modified="2017-01-18" version="1">MGHHASKHKHKSGIHSTTAKVGTPSSKPKSSTTAAPSSTSKSKLGSKLTTRSTSRKSQFTKESRPLGSKDENDHQNNVTLNAKEASAKAAEERLQKLQGQKSGQRDRLKDKAKQSKNDKGL</sequence>
</entry>
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    <name>A0A1D8PKZ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW28789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKZ6"/>
    <dbReference type="SMR" id="A0A1D8PKZ6"/>
    <dbReference type="STRING" id="237561.A0A1D8PKZ6"/>
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    <dbReference type="CGD" id="CAL0000193171">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07920W_A"/>
    <dbReference type="eggNOG" id="KOG3009">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Indigoidine synthase domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
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        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000193171"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="657" mass="71041" checksum="23652106A618826B" modified="2017-01-18" version="1">MKRSLLRISQEVRQALFEKRPVVSLESTIISHGLPYPQNIEMAKSVEQVLRDNGVVPATCAFIDGVPHVGLDNFEQLRNAVKVSRRDIGYVMANKLNGGTTIASTMILSHLAGIKVFATGGLGGVHRDGQYTMDVSADLTELGRTPVSVVCAGPKSILDIGLTMEYLETQGVFVGTYNPEKVDNLQVPGFYCRESGVPSPYGFESFAEAARVSYYQGMVGSGSVFCIPPPQETAMDSEYIRSVIEKANEKAKEVGVTGKKLTPFLLKEIAVATQGQSVESNIALVKNNARAAAEIAKELSQLERDASVLVVGSVALDTMAKLGPSTKMGDSNIGTVTNSIGGVGYNIARASGYVCDSTKFVSRVGNDAAGKTIQESVPGLGVGSGGTAQYVSMHDSSGELVVACADMSVIEEEFEVDHKASVAVYDCNLSPKTVSKALDNNEYNIIEPTSHVKARRIGEMELAVFPNNKVKLITPTVEELASIYDSMKDKFDDEWFGVLDAMKVDQIRERLDKKWYDKGVYQQCFQLLPFFQNILVKLGKDGVLLVSLCSTVEDYKSIPTTSPYRPKSIIYSKGNQVGAVVEYFPVPKDVEVVNVTGAGDTLVGYLAAKISESNWLHHEIGSAEQVWGKWESIYKAQLAAGLTLGCADSVIQEIANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="15">CAAX prenyl protease</fullName>
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    </protein>
    <gene>
        <name evidence="18 19" type="primary">STE24</name>
        <name evidence="19" type="ordered locus">CAALFM_C400280WA</name>
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    </gene>
    <organism evidence="19 20">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330898.1">
        <property type="nucleotide sequence ID" value="XM_019475353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL01"/>
    <dbReference type="SMR" id="A0A1D8PL01"/>
    <dbReference type="FunCoup" id="A0A1D8PL01">
        <property type="interactions" value="890"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL01"/>
    <dbReference type="GeneID" id="3645040"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400280WA"/>
    <dbReference type="CGD" id="CAL0000184268">
        <property type="gene designation" value="STE24"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00280W_A"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL01"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120236">
        <property type="term" value="P:negative regulation of post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="230"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000184268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW28821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="445" mass="50670" checksum="034840F3A21433AD" modified="2017-01-18" version="1">MISLAESFAFLDSPSINWKTIIVGFTIGQYVFETYLDLRQYRVLQSKTAPKSIEKEVSQETFDKSQEYSRAKAQFSVFSSTFSLLQNLAIFKYDLLPKTWTLAGTIMKSSAAVLPKAMSGVITQSLFFVFTTQILTTLIGLPLSYYKNFVLEERFGFNKQTIGLWVSDMLKGIGISIVLGSPVIAGFLKIIDYFDDKFIFYLMGFILVVNLIAMTIVPTLIMPLFNKFTPLEDGELKTAIEKLALEQKFPLTKLFVIDGSKRSSHSNAYFTGLPWSKQIVLFDTLIEHNSTEETVAVLAHEIGHWKLNHLPKMITMMQGHLFLIFSLYSAFIHNKSLYTSFGFVKQQPILIGFMLFNDIFQPVECLLTFVSNLISRKHEYEADKYASDCGYSEELSRSLIKLSNENLSSMNADWLFSSYHYSHPILPERLSALGYVSKVKVKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL46</accession>
    <name>A0A1D8PL46_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C400460CA</name>
        <name evidence="11" type="ordered locus">orf19.13120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713356.2">
        <property type="nucleotide sequence ID" value="XM_708263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL46"/>
    <dbReference type="SMR" id="A0A1D8PL46"/>
    <dbReference type="STRING" id="237561.A0A1D8PL46"/>
    <dbReference type="GeneID" id="3645010"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400460CA"/>
    <dbReference type="CGD" id="CAL0000187752">
        <property type="gene designation" value="orf19.13120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00460C_A"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL46"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000139">
        <property type="entry name" value="ATP-dependent helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004233">
        <property type="entry name" value="ATP-dependent helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    <name>A0A1D8PM79_CANAL</name>
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        <submittedName>
            <fullName evidence="4">Cdl1p</fullName>
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        <name evidence="3 4" type="primary">CDL1</name>
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    <organism evidence="4 5">
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    </organism>
    <reference evidence="4 5" key="1">
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PM79"/>
    <dbReference type="SMR" id="A0A1D8PM79"/>
    <dbReference type="STRING" id="237561.A0A1D8PM79"/>
    <dbReference type="GeneID" id="3641132"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405060WA"/>
    <dbReference type="CGD" id="CAL0000201881">
        <property type="gene designation" value="CDL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05060W_A"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4087411at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
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        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
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        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="179"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000201881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="673" mass="75344" checksum="30C72F7E7B5C8EE6" modified="2017-01-18" version="1">MSFDKSKSLLTVCDDLTQVKGNVSQFQAMVNNIISKAPTREEYEKLLKTIRLGEAPGETKQTIERLEQLITVSQTKIAVRLKELFLAGYLPLLTSLSKINFKSNIEDQFVSYFMDYNPALPSNVVQDLRVLQGKKADSLTAPIDIISYPPTLPAINSTILLLRIMTDRSYRQPSDFIESSSNDYNKSHNGRLVLRGRAIMQLCLVEVLEESYSRLLDEDIQFISHKLMAPIILTKFAFGYNLVDHLKYNVSVDADYEEKLQIIGNIFLAYMGGLKTEGYDLSDLKLFVKRLYEPVIADYMNKNDVLSKVALVELDLLFKSITNLLYLPRENIRYEIIQVESDPHVARILVDNEELGSGVSSVSFEEAKCRAAQDILNDHNRIRKIWEILKNNHTKNNTTETTTTTTTIKTEKPETIMQIPIQQAPPTMNSHIGTPVVEQATANIASVNAGSPPMQNHTAAISPSLANATARQTSPQFTMQPPSQQQQQQPFAFAQPQRYPGVAYQTPFLQQPQQPQPYVNSPMEYFHPMQQQNPHAQQATAHSPPPQLSQQPQPQSQAQPPSNGGPLYDQPSTSMNSEQIYVDQYGIPHLGTACKNVDTNARNDLYSKLGKAKIATPEYEDKISPEKVYHVLVSAKGIYLGGGYDLNKKLAAQKAAMCALANKVKLSELGLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMC0</accession>
    <name>A0A1D8PMC0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fmp27p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C405590WA</name>
        <name evidence="7" type="ordered locus">orf19.8825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716548.2">
        <property type="nucleotide sequence ID" value="XM_711455.2"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1D8PMC0"/>
    <dbReference type="FunCoup" id="A0A1D8PMC0">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMC0"/>
    <dbReference type="GeneID" id="3641776"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405590WA"/>
    <dbReference type="CGD" id="CAL0000181003">
        <property type="gene designation" value="orf19.8825"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05590W_A"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMC0"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1239"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
        <location>
            <begin position="1635"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1881"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2452"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2669"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2452"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2477"/>
            <end position="2488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2489"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2669"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2684"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2705"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2722"/>
            <end position="2735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000181003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2735" mass="314607" checksum="8F243CCBA899AFE3" modified="2017-01-18" version="1">MFNIYWILTISITIYLIVLFLINLIPNVSIKYVGFFSLRGITINTRKSTIYISKISLRFNLFESNKDSGFKLVNLEIVDVQVTIKETAGPGSSASKLKIKNAIENISLSEKLHFKVPNSLYEYLLKTRVANRINIHVFRCAITHQKILQDHSIFLDYTRFNVNVDKDNSTRVTVILFNGLIQDKIDRSNKINLFRNIEFYVNCQTVTSCGTTRSNAVSIYLSDFKTSLSIGRLNVPLDLFVKSQSKKDAGNVEDDLTNTKVIDVAKYKNFIKEFMSVYSTTEIRLEDLTLSHKSMRTNLSNFVLTLEKLEKDNGVTNLKFMWYLTSFKFYHIDTKCFELPSATFFYELCPIQFLTVAQSLLRHEKNPSETINFDFNLTMSNPVFDIYYDQQDIVLDILRDKMMKRRMNTMRKATGVQKKEEFFTKMSIASKMLKAVFSKLVVVDTKLNLHLPEFGKTEVGKFNRLSKSNSIITVALSELILKVFTRNINKGSNKFTLNTLFKMKNVKCEGQGNKFHFTKVNLLATYNMLQQNVSIKLSSKSLELLSANDLIFHIVRSFKNRQRIYFNKKFEEWKKMDVNNVCPWSEQMDNKSGAPVADTPANPEFIKLFEVLPSFISSVKIDISSIVMDMVCKEGLPSHKLYDEKLGKEIDLKDFRRGISFKVFDFSVTYKLARKHFETSVALLKAFTLSEYASEYIEDFDKVTEVQVSESEISDLSSINSAESIPLNDASPLELDESNTKKIKTVLTVRDILVSNAGKSDEKDPDRLTLSIPEVDGRVDMFLVWCCFYAKTMLERFKPTVESSCTKNQIKIIRGPRKKLKLDVHLDSVALVIRLPRKVDVMIEIDRARLKNALVLKSADIVNCRLYVVDPSTKFWARLLIIKEPKFSIDFTKSIHDAYFGISTRSIRISVPNRFLFYTVIDNFITFFKAIKQLSQNFRYFNWGIDEFETIYPSQKNAIVFPHVNIKTAVLGMELRADPFENKLALIFELGKIEQKERIRKWKAFEKKSQEILDGAESNIEDQIELSNIAAPISSPAPIASKTTTSTMTPNVAGDSITRPDSPPRSGSSECSFTSGAGLIKNKLLNRKKPTKTSVNGVAPVNEIEPADAKYTIEEAEERIAEAKERLFENFSKSWCRKYRVFEETKCRKWKERGENIWGSHDINEVMKEKYDIVEYDHGKPLTGAIFRDVDLTLDKFKLGDVDKFLYDYAKHQPKLTYSILCPMYVELKARKFYMILKDYPLPVASFPRSNTPSSPTIHIKTNLVIHEKLFSRKEELRYIYVPFSPAVPDDGRTDNFYSVNIPRTLTPVKVAADFNCDLNTDRSCTISWCKSYQPAFSAMAMAFENFTKPAIDDSPIGWWDKIPLIVHGRYQFNIANELCLHMKSGRNPHELIGKNAGFVFCWKNNVKLVIDGTINSKDLVVLESDDFIFAIPNYSIEEKNVWSLFYDDFDDPVPDIELESKKFNKYVIKLSSSERVRWVLGMLFERNKYPTQKFSDEELRVSTFKPHYEVMITNPANEFHPDSYEGYRSDYVHMSLSVISRAKTGETANTAYFTPLSFHHFFYWWDTLLHYSPPPIKRGKLFEMDQVKKPKIKFGTHMFTMKYQLIFNPVTISHLYRHSTSDVPKKNSRVAFTGLKGRFDVCEIDLHQRREYVTHENKKLNRKTKIRHLKMNQAEVNIENADARVIYALFNDTSVTGKLMTYLNADSSDSSTDGSQSSDYRGSSYSRWLENVEISDGDFSWYDPKDFIELEVREPLSPYPKTKILPFFATPKFSYYREFTLQKDGPFPFGSEKIHDCIMNLDKPAIVQSRILLDRLQNLEDELAHNEEMLRRFKIQNGPEFQHDIRMTEQEISTLKEKVEVVRAAYNGFSDDEFGGLPSSSANNVADDDDGSSSLSRSSTGLSAYSSHVTQDQMSQAAAFVSIAEFHNRFILHNLTLKWDDNISKYFISYMKRIAERKSHIYYMTKYAVDLVEKVMQENAKEGEPTLQPREKVFQKSFKQADNIVDSFEDDLDEVKDSEREEPEYKYLVKLIHPQIQMISRKAPDSCVLISSKDLELRIVDINMKDRVNILSENNEMTARIERRTGVLFREEQLFVLQRDEVVSNAKSKFAKNGYMSDKYNWPPWFECEVCYDGSWAHEYLVSEKNTIAIIQKSPNQLFISSEKLEQGNELVVYLSKYVINATSAQYSSIYYVITGLLLSNDDKESNYNGRLQRLMDLADASDFEGLDVRVHNLQQGIRDYRELLFSFDQKGADLNEEQKKYLHVLELEMERSKLELILIMNALQTRIKATSQLTSKCLQILADQVIWHMLDDDREPFIDFALASTRFIKHEAGDGSTVNILEIGMVQGFNLQEGAKYPQLLGPDINEEKKKLDSCHNEKPIISMSWTVLNAVGGIPIIKNAKLETQRLQLELEYATAKKLESYLFPKEANTEDTDEQDGDEFDDIYVNNQQNSMSDSTSDIEVSSNDSVLSSKNPLKRLMSKRSNRSPKSSSDSATSSPQQSLSLNSGVRSSNSSALSSDEISFGSGIKLNRPQLHLPLQKKREQQHEENDDEMEVIIARSLKFKSLIDIEIANFQMIISFSAPSTLHLLDVHRLVINIPTLRYVNKIWSAKELTDRLKKDVIKVILQHSGKILGNKFKAKKKTKTSEPLKQISNYSKYMTLDDLQQHGRERDSSTVDHEVHRKPRTSHKSGSRMSSIGRVLSRQSVNNNNSTFEKYLDDVDGSDEGAGIEEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PME2</accession>
    <name>ZCF5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc cluster transcription factor ZCF5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZCF5</name>
        <name type="ordered locus">CAALFM_C405700WA</name>
        <name type="ordered locus">orf19.8841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2913" last="2925">
            <title>Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.</title>
            <authorList>
                <person name="Garcia-Sanchez S."/>
                <person name="Mavor A.L."/>
                <person name="Russell C.L."/>
                <person name="Argimon S."/>
                <person name="Dennison P."/>
                <person name="Enjalbert B."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15814841"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-01-0071"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probably acts as a transcritpion regulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is regulated by SSN6.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716563.2">
        <property type="nucleotide sequence ID" value="XM_711470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PME2"/>
    <dbReference type="STRING" id="237561.A0A1D8PME2"/>
    <dbReference type="EnsemblFungi" id="C4_05700W_A-T">
        <property type="protein sequence ID" value="C4_05700W_A-T-p1"/>
        <property type="gene ID" value="C4_05700W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641819"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405700WA"/>
    <dbReference type="CGD" id="CAL0000195192">
        <property type="gene designation" value="ZCF5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05700W_A"/>
    <dbReference type="eggNOG" id="ENOG502QZSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PME2"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463335" description="Zinc cluster transcription factor ZCF5">
        <location>
            <begin position="1"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 3">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15814841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000195192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="971" mass="110896" checksum="A0C66BF6C2B0C4A8" modified="2017-01-18" version="1">MELEASDSNSFSMSTNETGKANPNVQIVQDGKVVKKVQKTRQRRILSCVYCHSKKIKCDRQKPCSQCTKLGMECKYFINERISRGGKKSSRLTADEKKLRGLMNSANENKKAKQESVETAKSQDTQSSSSSSPTNSSTTSTANPLAPSSSIATSIEEVEQQQFDTAPNTKDYTANPNQSQQEQLGIEDETFKTPSGLDISVSLLGFSNKPEASSNSNSLRSFTANVESPFSGADPFAIGGLIQSPMVNQATNSMTSSYFNHNFTTQATNHNNSINGANNQINFNSSSFPLANSDVSITFSSHANSPTMNFSERLQQQQQQQQQIPPRPESASIVKTQPQSSTLYNSLNGYTINTATSVNYLYGTNTYGENSTILNDITEYLPTDKDRSFELIDRYLNSVHLLLPIVVNMKEFLVQHKLYWEIKSRRDSTTADLNNPRVESPGSSHHSGDGGNEPMPSDSNFNYIQFYTLYLPILYASTISEFEEYDNLLLNQEIHKYLMGFKICKKYYNFPEGIKTIPLLLGNVIIQSTSPNPSTMEMAQIIRYAKFLHFHKDPWITLRIKDPEIIKFRRLLWWVIFGLDALSSHNFCLPPNCRSDDFNVLMPDEEEFIGGEKKLNVSIVSMNIKFGYDILLSEIVYHLHNGLCVNINCHQINQLKQSILSYQEQIKKYISKMDKYFQSKQIFADTLNHSPIQLLNVVNFVKIHSWSFLDRALMLLHKKILLGTPKNHNHNDEIENEIVQLGLKEPVMQIRANENPLSLCKFEDTYGQILEANIITNFNNSSISLLKFGDFENFSYGDLANNLIPSILHNFNDFLLYNDFIKFGKFNWFIKRTIPIDSVILLMIIISVKFKYQFITTEELSTYKNLINSVMYIINRKWFKNEKYKRMLSLTNMTWEYLLKKFDVNDVIAFDVKNSEGAKDLVSVNIMDTSQLKEKILYDLRHNFIDVVDYCSFYSSLENLLNELIKYIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMG7</accession>
    <name>A0A1D8PMG7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">HOS1</name>
        <name evidence="3" type="ordered locus">CAALFM_C406010CA</name>
        <name evidence="2" type="ordered locus">orf19.11889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711859.2">
        <property type="nucleotide sequence ID" value="XM_706766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMG7"/>
    <dbReference type="SMR" id="A0A1D8PMG7"/>
    <dbReference type="FunCoup" id="A0A1D8PMG7">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMG7"/>
    <dbReference type="GeneID" id="3646518"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406010CA"/>
    <dbReference type="CGD" id="CAL0000175821">
        <property type="gene designation" value="HOS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06010C_A"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMG7"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11680">
        <property type="entry name" value="HDAC_Hos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000043">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000175821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="436" mass="49187" checksum="FAEB6D98924C9D47" modified="2017-01-18" version="1">MNSVCLLYTIYPQKENVCSVCKQKKNAPQKKPCPPPCKYCQTSPMATKRKVYITLSESATKIVDLLPSNKGRQSLVLGLIEAYKLIDLCDGTIDIYPAQTKDLTTYHDDEFVKHLMGPRTFLDKNFNKIDKAETDLTNVVIEENDLDEKYGLTFDCYPFPSLDLYVQLTAASSINAARKIVQQVKETNDQIIAVNWYGGRHHCHKSHAAGFCYVNDVVLSINILRKNLGSVFYLDLDLHHGDGVENAFKFSKKVATCSIHRYDIGFYPGTGSLKSSRENTYNIPTEKGLNDSSMLWIIKEIVAPLISNFGPRAIVIQCGCDGLALDTHKEWNMTIKGYRDSIDWILSHFSEIPIMLLGGGGYSHTETAKCWTYLTGSVLGVSDIDTWDILPEHKNLDAYEKDGFRFWTDHNSGPSKMKDHNSVEYLNDIKTHLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMH6</accession>
    <name>A0A1D8PMH6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">TRP5</name>
        <name evidence="16" type="ordered locus">CAALFM_C406110CA</name>
        <name evidence="15" type="ordered locus">orf19.4718</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710312.1">
        <property type="nucleotide sequence ID" value="XM_705220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMH6"/>
    <dbReference type="SMR" id="A0A1D8PMH6"/>
    <dbReference type="FunCoup" id="A0A1D8PMH6">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMH6"/>
    <dbReference type="GeneID" id="3648087"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406110CA"/>
    <dbReference type="CGD" id="CAL0000186632">
        <property type="gene designation" value="TRP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06110C_A"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMH6"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="344"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000186632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW29338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="702" mass="76073" checksum="AF014A5BEC84E660" modified="2017-01-18" version="1">MSALLKETFARCKKEGRNALVNFITAGFPTIDDTIPILQNMQNAGVDIIELGVPFSDPIADGPTIQQANNIALDNGITVPKCLELLSQARDQGVTVPIILMGYYNPILKYGEQKFLKDAAEAGANGFIVVDLPPEEAIKFRTECTKYGLSYVPLVAPATSNDRLKILGEIADSFIYVVSKMGTTGASTKVSTGIQELCDRVRKYAGPDTPLAVGFGVSTREHFLTVGEVADGVVIGSKIITLIGDSKPGERGKVAYDYVQSILGNDFKPNYPKTFERNNNNQAKETKPVLEENHKYNPRFGDFGGQYVPEALHTCLAELEKGFEDAVADPEFWKEFRDLYSYIGRPSSLHKAERLSEHAGGAQIWLKREDLNHTGSHKINNALAQVLIAKRLGKKKIIAETGAGQHGVATATACAKFGLECTVFMGAEDTRRQALNVFRMKILGANVVPVKNGTQTLRDATSEAFRFWVSNLETTHYVVGSAIGPHPYPTLVRTFQSVIGQETKEQFKALNNGKLPNAVVACVGGGSNSTGMFSPFENDKEVKLLGVEAGGDGLDTERHSATLTAGIPGVFHGVKTYVLQDNDGQVHDTHSVSAGLDYPGVGPELAYWKSIGRAEFVAATDAQALEGFRLLSQLEGIIPALESSHAIYGAVELAKTMSKDQHIVINVSGRGDKDVQSVAEVLPKLGEQIGWDLRFEEDPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMV9</accession>
    <name>A0A1D8PMV9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">THS1</name>
        <name evidence="17" type="ordered locus">CAALFM_C500110CA</name>
        <name evidence="16" type="ordered locus">orf19.5685</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710514.1">
        <property type="nucleotide sequence ID" value="XM_705422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMV9"/>
    <dbReference type="SMR" id="A0A1D8PMV9"/>
    <dbReference type="FunCoup" id="A0A1D8PMV9">
        <property type="interactions" value="1042"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMV9"/>
    <dbReference type="GeneID" id="3647882"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500110CA"/>
    <dbReference type="CGD" id="CAL0000177380">
        <property type="gene designation" value="THS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00110C_A"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMV9"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
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    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
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    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="289"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000177380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW29457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="706" mass="81699" checksum="D130F681DDBFABE2" modified="2017-01-18" version="1">MSEVADKVKDLSLKDKKKKPTNPLYLDPQPEFIEERIKLFDELKAQYGEEISKKEKLPIKITLRDGTIKEGTAYETSPMDIANSIGKSFAERQVIAKVDGKLWDMPRPLEGDVKLEFLDFEHPEGKAVFWHSSAHILGEACECHYGCHLSHGPPTEDGFFYDMSINNGETFVTQADFGNLEQVATKAIKEKQKFERLEMTKEQLLKMFHYNKYKVKFISDKIPDGTSTTVYRCGPLIDLCVGPHIPHSGRIKAFKVLKNSSSYFLGDATNDSLQRVYGISFPDKKLMTEHLKFLAEAAERDHRKIGREQELFIFNEMSPGSAMWLPHGARIYNTLVDTLRTEYRKRGYEEVITPNMYSTKLWETSGHWQNYKENMFSFEVEKETFGLKPMNCPGHCILFKSRERSYRELPWRVADFGVIHRNEFSGALSGLTRVRRFQQDDAHIFCTTDQIGTEIAGVFDFLKKMYGIFGFEFKMELSTRPEKYVGDLDTWNSAEKKLEQALNDFLGEGKWELNPGDGAFYGPKIDIMISDALKRWFQCATIQLDFQLPQRFELEYKSDKGPNTRPVMIHRAILGSVERMTAILTEHYKGKWPFWLSPRQILIVPVGPKYYDYAQKLQKKLNDDYFFYCDVDVSGNTLPKKIRTGQMYKYNFIFIVGEEEENSESVNVRNRDIPEEQGKNAMVGFDDVVKQLVALRESKRSDNKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN64</accession>
    <name>A0A1D8PN64_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C501470CA</name>
        <name evidence="11" type="ordered locus">orf19.11617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711345.2">
        <property type="nucleotide sequence ID" value="XM_706253.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN64"/>
    <dbReference type="SMR" id="A0A1D8PN64"/>
    <dbReference type="FunCoup" id="A0A1D8PN64">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PN64"/>
    <dbReference type="GeneID" id="3647050"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501470CA"/>
    <dbReference type="CGD" id="CAL0000186403">
        <property type="gene designation" value="orf19.11617"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01470C_A"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN64"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="71"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000186403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW29580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="502" mass="55466" checksum="4AB85A36192422CA" modified="2017-01-18" version="1">MSVPKTKSSSNGYTSVPQGENQADNLSNSETLTNNNQERSTDEYELQTLNSLDYEVENGPEEQQEEEQTGSSTMKMAFMNMANSILGAGIIGQPYAFRNSGLIGGILIMILLTVLIDWTLRLIIKNSILSQTKSYQDTVNYCFGVWGKIVLLVSICSFAYGGCMAFCVIIGDTIPHVLKAFIPESITRSDGPLGWLFARNTIIVLFTTCISYPLSLNRDISKLAKASGFALVGMFIIVVLTIFRAPFVSPTIKGELTIKEWTVNANIFQGISVISFALVCHHNTMFIYQSMKNPSLAKFSKLTHISCLVSMIFCMIMAINGLINFGDITKGNILNNFKSNDNWINIARFCFGLNMLTTFPLEIFVVRDVLKEIILAKKASVDGSTADLELSSKQHFFITSFLVFSSMSVALFTCNLGMILELVGATSASLMAYIIPPLCYLKLSWNQVDYKSAMPKEKKKFIIFKAIPSIACVLFGFAVMFISSFMTIKNTSSDGGDHCVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN91</accession>
    <name>A0A1D8PN91_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fcr3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">FCR3</name>
        <name evidence="7" type="ordered locus">CAALFM_C501810WA</name>
        <name evidence="6" type="ordered locus">orf19.10704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714610.1">
        <property type="nucleotide sequence ID" value="XM_709517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN91"/>
    <dbReference type="SMR" id="A0A1D8PN91"/>
    <dbReference type="STRING" id="237561.A0A1D8PN91"/>
    <dbReference type="GeneID" id="3643760"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501810WA"/>
    <dbReference type="CGD" id="CAL0000185980">
        <property type="gene designation" value="FCR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01810W_A"/>
    <dbReference type="eggNOG" id="ENOG502S4CX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN91"/>
    <dbReference type="OrthoDB" id="4940293at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000185980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="399" mass="44560" checksum="3D44FC46F76FE44D" modified="2017-01-18" version="1">MNFKTENSTTPNGDWSQSKAFTNSGSSFPVLNGTCELDQENLALSNSGQPESIFTQDSGLHGIDVAAPSDITDLNNQSGYQYNNNLAHDLYFTGSMEMPTTQHPYITNTNNHLSYSNSSEEFSPIGNNMSPDSTGGANSNNFTSGNKRKASNESFSPLSGHHYGTESGNNNNNNGTSRSSQYSSHKSRKKLLDEKDAALIARDDSELTEEELQMKRKAQNRAAQRAFRERKESKLKELEAKLLASEEERQKLLDELEQIKKQNISIATENEILKHNGMGNINNDVQIGNLSSYGRLQVDKFNFPKTQKDFIEHVLQGTNHQLKDENKDKVYNDNQGHKLLALGAVWDYLQIKAEEADLDFNSIDFNDVMEKLKGNEKCHGYGPAYPLELVNEAIESSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNG4</accession>
    <name>A0A1D8PNG4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spr28p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">SPR28</name>
        <name evidence="8" type="ordered locus">CAALFM_C502540CA</name>
        <name evidence="7" type="ordered locus">orf19.11742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330965.1">
        <property type="nucleotide sequence ID" value="XM_019475420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNG4"/>
    <dbReference type="SMR" id="A0A1D8PNG4"/>
    <dbReference type="STRING" id="237561.A0A1D8PNG4"/>
    <dbReference type="GeneID" id="3637716"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502540CA"/>
    <dbReference type="CGD" id="CAL0000188390">
        <property type="gene designation" value="SPR28"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02540C_A"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNG4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="393" mass="45033" checksum="BA52FB193C9E9A5C" modified="2017-01-18" version="1">MTSNNRRSVYIVSRFSVCFSFTYNQKWLQTKQNKTKQTNKKRESSTVNPTSPSTTLDSNHMIYTAEQIRHKKKLKKGINFNLLVVGVNDLGKKTFINTLINQPYYQINQPIPNTSHSSIAGTSNSEFSENSSNNNEFSIETNSFECCPRSIPIKLKISVTNNFGFNVHNDSHGDTLLSFIENKHRAILHEELKICRNPNLQDNRLHLGLYFINANVKGLSKFDISMMTKICHRINLLPIIAKRDGLTDIELIQCKHAINRDISENKIQIFNFLSKSNDDAGADAGADANADHHYKRDGDIEEYMTLSAKEYNYLSELNKSIPFAIIGSNSIVGDPQNEIVRNTKWGSIQIEDKNICDFKILKNIIFETHLQEFKDVTVEKIYEKFRVEQLIKN</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <location evidence="1">Nuclear pore complex</location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPM7</accession>
    <name>A0A1D8PPM7_CANAL</name>
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        </submittedName>
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        <name evidence="11" type="ordered locus">orf19.10949</name>
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    <organism evidence="12 13">
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716752.2">
        <property type="nucleotide sequence ID" value="XM_711659.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPM7"/>
    <dbReference type="SMR" id="A0A1D8PPM7"/>
    <dbReference type="FunCoup" id="A0A1D8PPM7">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPM7"/>
    <dbReference type="GeneID" id="3641605"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601390WA"/>
    <dbReference type="CGD" id="CAL0000179200">
        <property type="gene designation" value="HOC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01390W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPM7"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF11">
        <property type="entry name" value="GLYCOSYLTRANSFERASE HOC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000179200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="395" mass="45888" checksum="AB9E42CBC6CD9C57" modified="2017-01-18" version="1">MTKYTTTASRRTGFRRHIPIILIIIILGLLVTFFFGFSSFKGAKDIQEVISNLPNDKILGLSNILSTENSKNQGELLIKIEKLHNKYYKDQEERLKKIEKQNNEILQEIKLLKSPPQHASIREKLTFVYPYDADVRFPAYIWQTWKHGLNDEKFDEKYREGERQWAYKNPGFVHELFNDDTAHTMIKYLYRQIPEVINAFEALPEVILRMDFFRYLILFAKGGVYADIDTFPIQPIPNWIPENVSPLDIGLIVGVESDSNSPNWRSESVRRLQLGQFVLQSKPGHPILREIIAQIVLYTKKLEVPELNGNPNAKAIAIMKWTGSGRFTDVVFQYLNDYILSSIYESINWQHLHNLEVPKLLGDVLVLPRVSFSADDEKNPLSFVKHYGDKIYKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPU3</accession>
    <name>A0A1D8PPU3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C602180WA</name>
        <name evidence="7" type="ordered locus">orf19.10962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712498.1">
        <property type="nucleotide sequence ID" value="XM_707405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPU3"/>
    <dbReference type="FunCoup" id="A0A1D8PPU3">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPU3"/>
    <dbReference type="GeneID" id="3645861"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602180WA"/>
    <dbReference type="CGD" id="CAL0000186105">
        <property type="gene designation" value="orf19.10962"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02180W_A"/>
    <dbReference type="eggNOG" id="KOG3393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPU3"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000186105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19801" checksum="712CA7BDCA72922B" modified="2017-01-18" version="1">MDHNHSSNLFRFASIQLPKSAKLRSFGIYLSGALFAIGFWSLVDASIYSKTINASDVHVNFIDWIPFLASSMGMLIVNSIEKSNLMINPNNQSDFTGSGGNGGGHAWAARIILFMGFSLLAGGLAGSFMVFILKYLMNHYTFPTLGMGVANIVCNGCVMLSCIFLWLSQNIEDEYSYSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ34</accession>
    <name>A0A1D8PQ34_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mdl2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">MDL2</name>
        <name evidence="13" type="ordered locus">CAALFM_C603140CA</name>
        <name evidence="12" type="ordered locus">orf19.13043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719161.2">
        <property type="nucleotide sequence ID" value="XM_714068.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ34"/>
    <dbReference type="SMR" id="A0A1D8PQ34"/>
    <dbReference type="FunCoup" id="A0A1D8PQ34">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ34"/>
    <dbReference type="GeneID" id="3639256"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603140CA"/>
    <dbReference type="CGD" id="CAL0000176022">
        <property type="gene designation" value="MDL2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03140C_A"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ34"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001371">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="127"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="460"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="708"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000176022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW30245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="783" mass="87740" checksum="60A97B709C287395" modified="2017-01-18" version="1">MIILPSVRNLLFLSSRKSIKVLPARQYLQNLTFTSTRLNLIHSTPSSYLLKTACLSQFRTYATTPSSNLPPSQVLVKSHLDATNLKKKEIKQERFEEFQKQENKKTFKQNLRTIGRIIKLGKPDWKLFVLAIGFILCAVLYPTTAVKLVGSVLDSFNNNIKDKDGDLIVWGYKVSTVFAVMIPFMAVSAVCFWARIWVLKLLGERLVARLRARVMKNLLRHDQEFFDNDKHKVGDLISRLSSDAYIVSRSITSNLPDGLKNLLFGLLSSYMMYSINPMLFGMMLLISPPITIGSVFYGEKIRKLSTNLQNATAGLTKVSEETLNSIKLINAFTGEQKELRKYSTRLRRVVDVAKQEAFAQSNYSVSIYSLYHTGYLACVALGVYLMTKGTMSAGDVVAFTMYSEFFNSALYSLTTTYLELMKGAGAGVKLFALIDYKNKVPAIQGEKVTTWRPTSVKDDIQFNDVTFSYPTRPNHTIFDHCNFKIVGGTSTCIVAPSGAGKSTVASLLLRAYDIQSGEILIGGKNIKDIQVRDLRRYIIGIVQQEPVLLSGTILENIVYGLTSSEINRLTMQDIIDVSKQANCHDFIVTFPDGYDTIIGNRGASLSGGQKQRIAIARALIKRPKVLILDEATSALDSKSESLINETLKNLTNEGSMTIISIAHRLSTISKSEFVVVLGKHGQVVETGKFVELFSDPDSELSKLLDESATSQAAADRQEEEEELQQENRHKTQEDEREHINREAEEIENEQIKYSKAKNLIESLPSDMKQQLLTEINIEEKHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ89</accession>
    <name>A0A1D8PQ89_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial 37S ribosomal protein MRP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C603730CA</name>
        <name evidence="7" type="ordered locus">orf19.13170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718083.2">
        <property type="nucleotide sequence ID" value="XM_712990.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ89"/>
    <dbReference type="SMR" id="A0A1D8PQ89"/>
    <dbReference type="FunCoup" id="A0A1D8PQ89">
        <property type="interactions" value="798"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ89"/>
    <dbReference type="GeneID" id="3640303"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603730CA"/>
    <dbReference type="CGD" id="CAL0000181894">
        <property type="gene designation" value="orf19.13170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03730C_A"/>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ89"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000055">
        <property type="entry name" value="Mitochondrial ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000181894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="460" mass="52065" checksum="DC7D5D363A3CCD15" modified="2017-01-18" version="1">MIRSTTATTTTLRYCARIFRNLSRSYSTENSQPNPNEQPPLEHTLSHKELREQAIAEALAREEEAILKTKKLRELTQESQNLISALNKTPTTLINERLNKLHEDLSKLSQDKIKQLDEELKDYLNQNMILPDHLKANRPWLRSSDNNEDISKKLKSSINSASSSDSNHTSTTTTSSRYTEQFPNLKPTPDYKPYSEQELYIRQLNHTRINGRIGSRLTQVYKPQRDINNPPKFDNTTIAKLMAAGCHLGHSTSSFRPSMQPFIYGIYDKVHIIDLNKTLEKLTLACKVIEGVVEKGGVVLYVGTHKNNSSIQEALVKASERSHGYYVNKRWIPGTITNYTEVTKQYGQIKTKMEVDMKDQKITTKNSNKIIKPDLMVLLNPVENRNCIKECISAGIPTIGLCDTDMEPSLLTYPIPCNDDSVRSVNLMLGIMSKSAESGLQKRISAVKKLEENDGKVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRI8</accession>
    <name>A0A1D8PRI8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C704070CA</name>
        <name evidence="3" type="ordered locus">orf19.7170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111355" evidence="2">
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            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
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        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="129" mass="12613" checksum="3FE8FB2E27123F59" modified="2017-01-18" version="1">MKFTTIAAAAFIACSVEATFLPLLKLGGGWKGGNNEPPCDTPAPPPPPPPPAQTTPCDTPPAPPAPTTPCDTPPAETTPCDTPPAQPTPCETEGGSGGNGGSGGYGGGGIIGSIIGKKVKFIEGLLGGH</sequence>
</entry>
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        <submittedName>
            <fullName evidence="6">Ngs1p</fullName>
        </submittedName>
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    <gene>
        <name evidence="5 6" type="primary">NGS1</name>
        <name evidence="6" type="ordered locus">CAALFM_CR00190WA</name>
        <name evidence="5" type="ordered locus">orf19.7516</name>
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    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
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        <property type="protein sequence ID" value="AOW30790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
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        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRN5</accession>
    <name>A0A1D8PRN5_CANAL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ordered locus">CAALFM_CR00160CA</name>
        <name evidence="1" type="ordered locus">orf19.7519</name>
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    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718676.1">
        <property type="nucleotide sequence ID" value="XM_713583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRN5"/>
    <dbReference type="GeneID" id="3639706"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRN5"/>
    <dbReference type="OMA" id="CDLEIHC"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000176944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="146" mass="16460" checksum="CFBB498DFB18D674" modified="2017-01-18" version="1">MEVATSNPQPKPQTINKQVTFQFANECDLEIHCSPFGLSGLYIKINGTDIMGIGSTMGLITGSTRGLIHYNDSNDLIDQKYKLYVVIDDDDMLRIDFTKIYTDASNDNNEKQIQEVPTLVFRGKCPEGRPDTIEPFIGIFSFERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS16</accession>
    <name>A0A1D8PS16_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">FRS1</name>
        <name evidence="19" type="ordered locus">CAALFM_CR01760CA</name>
        <name evidence="18" type="ordered locus">orf19.10105</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718239.2">
        <property type="nucleotide sequence ID" value="XM_713146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS16"/>
    <dbReference type="SMR" id="A0A1D8PS16"/>
    <dbReference type="FunCoup" id="A0A1D8PS16">
        <property type="interactions" value="1152"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS16"/>
    <dbReference type="GeneID" id="3640121"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01760CA"/>
    <dbReference type="CGD" id="CAL0000190210">
        <property type="gene designation" value="FRS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01760C_A"/>
    <dbReference type="eggNOG" id="KOG2472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS16"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="291"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000190210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW30935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="592" mass="66836" checksum="6CAA8FCC4F1AC9D8" modified="2017-01-18" version="1">MPTIPVDKEDLFKLLGRSYTTEEFDELCFQFGIELDEDTTEDVKGTDERPQLKIEVPANRYDMLCIEGIAQALNEFLGNTSAPNYKLSPSKPEISLTIKESTYPIRQYAASAILRNVNLDERAYDSFIALQDKLHANLCRNRTLVAIGTHDLDTLTPPFTYEALAPKDIVFKPLNQTKEINGEELMEFYEKDKNIGKFLHIIKDSPVYPVMLDANRTVASLPPIINSDHSKITLNTKNVWIDVTGTDRTKTEIVINQLVAMFSRYCKEPFEIEPIQIISEHNNETRVCPNITPRTAKAEISYINSCVGLDYSGEEISKLLKKMSLDATPSTEERDILDVKIPITRSDILHQCDIMEDVAIGYGYDNLKKTKPKAESLVAAPLPVNKVADILRLASSQAGYLEVMPLTLSSHDENFAWLKQKDDGTKAVKLENPKTIEYQVVRTTLLPGILKTVKENRKHSLPIKVFECGDIVLKNPELERGAFNQRNWAALYVGKTSGFEMVQGLLGKIMQTMRTPWLENPSKDQRRGYWIEEDKENTTFFPGRGAKIYFRNADNAEAKAIGSIGVLHPEVMNNFDIPYAASSVEINAEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSM8</accession>
    <name>A0A1D8PSM8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_CR04020CA</name>
        <name evidence="6" type="ordered locus">orf19.8115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710157.2">
        <property type="nucleotide sequence ID" value="XM_705065.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSZ6"/>
    <dbReference type="STRING" id="237561.A0A1D8PSZ6"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PSZ6"/>
    <dbReference type="GeneID" id="3648242"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05430WA"/>
    <dbReference type="CGD" id="CAL0000186704">
        <property type="gene designation" value="CSP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05430W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PSZ6"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111264" evidence="6">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="7">
        <location>
            <begin position="247"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000186704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="354" mass="41645" checksum="B7C987D1035E738C" modified="2017-01-18" version="1">MKFSTAALTFSLLAIVNSSVITYDTEFGDNYEHKHDKYDCEIDTFNWKFALVVKEWKYHKDEKFCKDTDLDLVYEGEDGQLYHGCDGTYPYSKCKHCTNVFAGGDDNKWKDDKWDDKYKDKKCHDKWDDKCKDKCDDKHKDDHCKDKKCDDKWDNKCHDKCKDDDKCHDKCKDKKCDDKQKHDHCKDDNKCHDKCKDKKCDDKCKDGDDKCHDDCKDDDKCDKHHCKYPYCEIHNTDCDLLITLCNGVLKDKRDATGEIAANHQFQFDKPPQKDALHKEGFSIVHTEGTYYLALNHKIEFWHCKVDDKGLYKIYDKSIGPQCSKIELIVLKSDEKATFSNDDCDDDCKKKQKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTA5</accession>
    <name>A0A1D8PTA5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_CR06570CA</name>
        <name evidence="4" type="ordered locus">orf19.915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710034.2">
        <property type="nucleotide sequence ID" value="XM_704942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTA5"/>
    <dbReference type="SMR" id="A0A1D8PTA5"/>
    <dbReference type="STRING" id="237561.A0A1D8PTA5"/>
    <dbReference type="GeneID" id="3648366"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06570CA"/>
    <dbReference type="CGD" id="CAL0000176439">
        <property type="gene designation" value="orf19.915"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06570C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PTA5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000176439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="705" mass="81911" checksum="DFD4BBF0EA28C37E" modified="2017-01-18" version="1">MYMILSVINSIGGNINELITRNEYNNNNLMTLPLPNSIKKLAITFNYYQQRNEEFIYLNINQYLSVGLTHLSIRFPEYFNTINNNEEVQVQAQVQNAAADANANANDDDKMIIDFQRFINLKYLKFYDITFDIEFILPNDLKYLYFKNCLPNKIYFHEFFEEKDLNFNKLDSFIWESPQINLDMVKFDNIDAYNNNYYYLLIHNGIGLKNLKIPQCMINSILSKIDNSSSNQITDSFIVKKVVELPSSLQKLILYNHTQNDNNNEDDEQEDEHEQEDEQEDEHEHDDDDDDVHQHQHGNIDRYCFHFKYLFPFHSNLTSLTVDGVNVVNFHNFDNLINLKTLNIYNQFKSCHKTFDYKLPISLTRLIFDHCHYQQYLIDNSTNNNNNLYNLKYVQITNCGLNNIDQSILKLPDNVEELNLNNNCIGIIDNPSNQNQNQNQNQEITIDKIFPKNLKTLHLCYNQLMHVKSLPSSLISLYLSHNQLNQQRFMEPSTLVLSNLKHLDLSYNIFNLNELTTTDSFLQSTTNLETLNLSSNLTTTTTAITTTNITNINTNSIVIGNCFPSSLIELKLSYNNLKYLISGGGGGGDGNGGGFEQFLPNLQHIDLSGNLLGDSLNKGFLQTWKNLYHHQNEQIIIIDELKFGNNIKTVNLLGNRLSKNTIRDLMNYQLMKNPKFRCLIIENSLIPQDLYKYISQTYIMEPINN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTI7</accession>
    <name>RS27_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS27</name>
        <name type="ordered locus">CAALFM_CR07630CA</name>
        <name type="ordered locus">orf19.6286.2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331100.1">
        <property type="nucleotide sequence ID" value="XM_019475555.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="c=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="c=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
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</entry>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <submittedName>
            <fullName evidence="10">L-iditol 2-dehydrogenase</fullName>
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        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Dungan J."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PUB4"/>
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    <dbReference type="STRING" id="237561.A0A1D8PUB4"/>
    <dbReference type="GeneID" id="3638961"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10840CA"/>
    <dbReference type="CGD" id="CAL0000192665">
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    <dbReference type="eggNOG" id="KOG0024">
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    <dbReference type="InParanoid" id="A0A1D8PUB4"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="C:hyphal cell wall"/>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:sorbitol catabolic process"/>
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    </dbReference>
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        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000192665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="360" mass="38771" checksum="B73D9B185C7F6255" modified="2017-01-18" version="1">MTNPSLVLNKIDDISFEDYESPEITSPRDVIVEVKKTGICGSDIHYYAHGSIGPFVLRKPMVLGHESAGVVVAVGDDVTNLKVGDKVAIEPGVPSRYSDEYKSGNYHLCPHMAFAATPPVNPDEPNPPGTLCKYYKAPADFLFKLPDHVSLELGAMVEPLTVGVHACKLANLKFGENVVVFGAGPVGLLTAAVAKTIGAKNIMVVDIFDNKLQMAKDMGAATHTFNSKTGDDLVKAFDGIEPSVVLECSGAKQCIYTGVKILKAGGRFVQVGNAGGDVNFPIADFSTRELTLYGSFRYGYGDYQTSIDILDKNYINGKENAPINFELLITHRFKFKDAIKAYDLVRGGNGAVKCLIDGPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>P33181</accession>
    <accession>A0A1D8PTX7</accession>
    <accession>Q5A3Z0</accession>
    <name>SUC1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable sucrose utilization protein SUC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SUC1</name>
        <name type="ordered locus">CAALFM_CR09210WA</name>
        <name type="ORF">CaO19.7319</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Bacteriol." volume="174" first="222" last="232">
            <title>A zinc finger protein from Candida albicans is involved in sucrose utilization.</title>
            <authorList>
                <person name="Kelly R."/>
                <person name="Kwon-Chung K.J."/>
            </authorList>
            <dbReference type="PubMed" id="1729210"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Affects sucrose utilization and alpha-glucosidase activity. Probable transcriptional activator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="S75352">
        <property type="protein sequence ID" value="AAB20826.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A43302">
        <property type="entry name" value="A43302"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716453.1">
        <property type="nucleotide sequence ID" value="XM_711360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P33181"/>
    <dbReference type="SMR" id="P33181"/>
    <dbReference type="FunCoup" id="P33181">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P33181"/>
    <dbReference type="EnsemblFungi" id="CR_09210W_A-T">
        <property type="protein sequence ID" value="CR_09210W_A-T-p1"/>
        <property type="gene ID" value="CR_09210W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641916"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09210WA"/>
    <dbReference type="CGD" id="CAL0000197139">
        <property type="gene designation" value="SUC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09210W_A"/>
    <dbReference type="eggNOG" id="ENOG502S2FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_7_1_1"/>
    <dbReference type="InParanoid" id="P33181"/>
    <dbReference type="OMA" id="KLFEVAM"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000119">
        <property type="entry name" value="Probable sucrose utilization protein SUC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000114981" description="Probable sucrose utilization protein SUC1">
        <location>
            <begin position="1"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="501" mass="57110" checksum="E9BC5BFC2C8183E9" modified="1995-11-01" version="2">MSKGKRAPYTRPCDSCSFRKVKCDMKTPCSRCVLNNLKCTNNRIRKKCGPKKIRDRTREAINNLSNKEDPKTNSFIPHFQLDKLQPCLETYQTWYYGIWPVLSISDLNMKITKRDVSAYALACALSAAILNQIDFISNNGTYCIPEDVKKLDFIGECIRARTFMNYQMTPTLETILTSFFLHVAEVNKGSKPAAIIYLREAITMAQIIGLHNESTYKSKPVAEAHRMRKIYFMLMVTERFMCIDDLIPVVLENSIKEFSLDDEQYSVLIDGFKELVKVFSIPSKAIFDRFIQMNDSISMPPETAGLLNKIQLELESICISPVAPDIQKANIIVSKYWMKALTWKITRKNNLLDDFVTTLCVKYPIELSEQFLGEIKSIPLRAFESNGPGVVFKLLSIATVLIDSINLSNDVSGYESLQRMFDLISKLKKTDMIIPRREYDRIKEALTKMEIDIFFSSAQSGGYISEVESNGSLDAFLTDPLVFYSGSNDNPTPSYIPDYQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2025-02-05" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>P43094</accession>
    <accession>A0A1D8PQ36</accession>
    <accession>Q5ABW5</accession>
    <name>CARP5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Secreted aspartic protease 5</fullName>
            <shortName evidence="14">ACP 5</shortName>
            <shortName evidence="14">Aspartate protease 5</shortName>
            <ecNumber evidence="8 9">3.4.23.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Candidapepsin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SAP5</name>
        <name type="ordered locus">CAALFM_C603030WA</name>
        <name type="ORF">CaO19.13032</name>
        <name type="ORF">CaO19.5585</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Mol. Microbiol." volume="13" first="357" last="368">
            <title>Multiplicity of genes encoding secreted aspartic proteinases in Candida species.</title>
            <authorList>
                <person name="Monod M."/>
                <person name="Togni G."/>
                <person name="Hube B."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="7984113"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1994.tb00429.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>C74</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2001" name="J. Med. Microbiol." volume="50" first="743" last="747">
            <title>Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo.</title>
            <authorList>
                <person name="Schaller M."/>
                <person name="Januschke E."/>
                <person name="Schackert C."/>
                <person name="Woerle B."/>
                <person name="Korting H.C."/>
            </authorList>
            <dbReference type="PubMed" id="11478679"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="J. Biochem." volume="150" first="431" last="438">
            <title>Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.</title>
            <authorList>
                <person name="Aoki W."/>
                <person name="Kitahara N."/>
                <person name="Miura N."/>
                <person name="Morisaka H."/>
                <person name="Yamamoto Y."/>
                <person name="Kuroda K."/>
                <person name="Ueda M."/>
            </authorList>
            <dbReference type="PubMed" id="21646240"/>
            <dbReference type="DOI" id="10.1093/jb/mvr073"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Infect. Immun." volume="73" first="1828" last="1835">
            <title>Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection.</title>
            <authorList>
                <person name="Taylor B.N."/>
                <person name="Staib P."/>
                <person name="Binder A."/>
                <person name="Biesemeier A."/>
                <person name="Sehnal M."/>
                <person name="Rollinghoff M."/>
                <person name="Morschhauser J."/>
                <person name="Schroppel K."/>
            </authorList>
            <dbReference type="PubMed" id="15731084"/>
            <dbReference type="DOI" id="10.1128/IAI.73.3.1828-1835.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Pol. J. Microbiol." volume="61" first="247" last="256">
            <title>In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms.</title>
            <authorList>
                <person name="Staniszewska M."/>
                <person name="Bondaryk M."/>
                <person name="Siennicka K."/>
                <person name="Kurek A."/>
                <person name="Orlowski J."/>
                <person name="Schaller M."/>
                <person name="Kurzatkowski W."/>
            </authorList>
            <dbReference type="PubMed" id="23484407"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="Peptides" volume="48" first="49" last="58">
            <title>Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.</title>
            <authorList>
                <person name="Bochenska O."/>
                <person name="Rapala-Kozik M."/>
                <person name="Wolak N."/>
                <person name="Bras G."/>
                <person name="Kozik A."/>
                <person name="Dubin A."/>
                <person name="Aoki W."/>
                <person name="Ueda M."/>
                <person name="Mak P."/>
            </authorList>
            <dbReference type="PubMed" id="23927842"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2013.07.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2013" name="Biochem. Pharmacol." volume="85" first="881" last="887">
            <title>Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans.</title>
            <authorList>
                <person name="Cadicamo C.D."/>
                <person name="Mortier J."/>
                <person name="Wolber G."/>
                <person name="Hell M."/>
                <person name="Heinrich I.E."/>
                <person name="Michel D."/>
                <person name="Semlin L."/>
                <person name="Berger U."/>
                <person name="Korting H.C."/>
                <person name="Holtje H.D."/>
                <person name="Koksch B."/>
                <person name="Borelli C."/>
            </authorList>
            <dbReference type="PubMed" id="23262278"/>
            <dbReference type="DOI" id="10.1016/j.bcp.2012.12.008"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference evidence="15" key="11">
        <citation type="journal article" date="2008" name="Proteins" volume="72" first="1308" last="1319">
            <title>X-ray structures of Sap1 and Sap5: structural comparison of the secreted aspartic proteinases from Candida albicans.</title>
            <authorList>
                <person name="Borelli C."/>
                <person name="Ruge E."/>
                <person name="Lee J.H."/>
                <person name="Schaller M."/>
                <person name="Vogelsang A."/>
                <person name="Monod M."/>
                <person name="Korting H.C."/>
                <person name="Huber R."/>
                <person name="Maskos K."/>
            </authorList>
            <dbReference type="PubMed" id="18384081"/>
            <dbReference type="DOI" id="10.1002/prot.22021"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 77-418</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8 12">Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:18384081, PubMed:23927842). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (PubMed:11478679, PubMed:23927842). Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein (PubMed:23927842).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Inhibited by pepstatin A analogs.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="9">Optimum pH is 5.0.</text>
        </phDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="7 11">Expressed during development of germ tubes, pseudohyphae and true hyphae (PubMed:23484407). Induced during host infection (PubMed:15731084).</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="8 9"/>
    <dbReference type="EMBL" id="Z30191">
        <property type="protein sequence ID" value="CAA82923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S49056">
        <property type="entry name" value="S42072"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719147.1">
        <property type="nucleotide sequence ID" value="XM_714054.1"/>
    </dbReference>
    <dbReference type="PDB" id="2QZX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=77-418"/>
    </dbReference>
    <dbReference type="PDBsum" id="2QZX"/>
    <dbReference type="AlphaFoldDB" id="P43094"/>
    <dbReference type="SMR" id="P43094"/>
    <dbReference type="STRING" id="237561.P43094"/>
    <dbReference type="ChEMBL" id="CHEMBL6019"/>
    <dbReference type="MEROPS" id="A01.063"/>
    <dbReference type="EnsemblFungi" id="C6_03030W_A-T">
        <property type="protein sequence ID" value="C6_03030W_A-T-p1"/>
        <property type="gene ID" value="C6_03030W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639268"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603030WA"/>
    <dbReference type="CGD" id="CAL0000193807">
        <property type="gene designation" value="SAP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03030W_A"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="P43094"/>
    <dbReference type="OMA" id="NESETWI"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="BRENDA" id="3.4.23.24">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="P43094"/>
    <dbReference type="PHI-base" id="PHI:126"/>
    <dbReference type="PHI-base" id="PHI:6787"/>
    <dbReference type="PHI-base" id="PHI:6793"/>
    <dbReference type="PHI-base" id="PHI:6808"/>
    <dbReference type="PHI-base" id="PHI:6815"/>
    <dbReference type="PRO" id="PR:P43094"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000023">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000025856" description="Activation peptide" evidence="3">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000025857" description="Secreted aspartic protease 5">
        <location>
            <begin position="77"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="90"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
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        <scope>GENOME REANNOTATION</scope>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710789.1">
        <property type="nucleotide sequence ID" value="XM_705697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59M28"/>
    <dbReference type="SMR" id="Q59M28"/>
    <dbReference type="FunCoup" id="Q59M28">
        <property type="interactions" value="884"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59M28"/>
    <dbReference type="GeneID" id="3647604"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112570CA"/>
    <dbReference type="CGD" id="CAL0000191392">
        <property type="gene designation" value="orf19.11243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12570C_A"/>
    <dbReference type="eggNOG" id="KOG3949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="InParanoid" id="Q59M28"/>
    <dbReference type="OMA" id="QGMLKVH"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000191392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="446" mass="49213" checksum="BFB147A730C81062" modified="2005-04-26" version="1">MSFRKRGEIIGGSPAPNRGPIGSIPARAPGIAGRAPPLGRTPPAVTGKGITTTTTSSFQLKSKPKSIEKDNATQIMQNPGVRPSLVTSQPTTSTGSSDLDKILLHQGLPLGNSLLIEESGTTDFSSVLLRAFASQGILHNRISNDINAHVIVLGMNQQWANDLPGVYKGSSKEQKKAKIIENESKVSVSNLSNAPSTTNRTTTDPNLKIAWRYGLNKKPESKDENESSNSYEHYNNQFDLTQKLVPGPNPQDISFLPLNAEFNNMVNQISSIIKNQLRSNPTKVIRLIIPSILNPSLYHPSCSSSTFIVPFIHSLRSLVRRFSNNLVLVCSISLDLYPKDSSLLLFIQSLFDAIIHLQPFNQEMTQLLEKAYKNEPTKIQQGLVNIIKIPILSEKGLMMVHDGEYAFKNGRKKFEIEEWSIPVEDDSKDDTHQTQEGGTTTKNIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q59MF4</accession>
    <name>Q59MF4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tethering complex ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">VPS33</name>
        <name evidence="3" type="ordered locus">CAALFM_C205940CA</name>
        <name evidence="2" type="ordered locus">orf19.12681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710922.1">
        <property type="nucleotide sequence ID" value="XM_705830.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59MF4"/>
    <dbReference type="SMR" id="Q59MF4"/>
    <dbReference type="FunCoup" id="Q59MF4">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59MF4"/>
    <dbReference type="GeneID" id="3647477"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205940CA"/>
    <dbReference type="CGD" id="CAL0000186305">
        <property type="gene designation" value="VPS33"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05940C_A"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344541_0_0_1"/>
    <dbReference type="InParanoid" id="Q59MF4"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000186305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="698" mass="80084" checksum="23E6299720846D3A" modified="2005-04-26" version="1">MKDINATENNLASKFQRFNDKTLENLINQISKIYSSNNLLVLDAVLSPLINSLTNFTKLKELGKFQNIVWLDNELVSIGSSVLAKYASLIVVVPTSSLENINILNKLIHSQPDLHSLKLNIIVKDLKMSFMYQINKVFNGIVNFESILSPEKYQKPISVTSRIKIYNWKTSPIYTDEILVTEINKFNGIDDYFSKPLKQVNQLSEALMQLLFMGIQNGKHDHLFKLRNIYGKGNHSKLLIDQLQNSKIPEFMNENMTTLEIDFYSDVLHSNTDLVVLERNLDFTSCIFNQLNYHGIIDDMFSIKFENIEQLSSNEISKSLANDKLYSQDLKHLNFSSIGLRLNKLAKYIQQQFKTSSAQKNSSSSEPNISDIKQLVSNLGTLSIQQELVKKHTIIGEEVMEKINKNYEQFLTFQNDIFEMDYKSQVAKLREFVNCNYPIEFVLSAILLIGYLNDGISNKEIDWLSLEMQDNYGLEAVFTLEKLIKFKMIRVIHGSSVDFFSSLGFTSQKKKPTTHSQSEFEDDKNVGISGSGDVFRNNYTLINKFWNLHPLDDDESLSQNLTESGSNESTNLLDLYSNPSFTLPGNTVPLIYRFVEALYFRDFLKHKPINNLKRRPNWDNLGVNTMFAGKTIDLNLDNVNDDRSKYLVIVVIGGVTRSELTCFKYLQERFRKQGKTKEIIIVSNGIVNSSKLMQFMSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PR3</accession>
    <accession>A0A1D8PT34</accession>
    <name>DBP8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP8</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP8</name>
        <name type="ordered locus">CAALFM_CR05630WA</name>
        <name type="ORF">CaO19.13973</name>
        <name type="ORF">CaO19.6652</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711718.1">
        <property type="nucleotide sequence ID" value="XM_706626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PR3"/>
    <dbReference type="SMR" id="Q59PR3"/>
    <dbReference type="BioGRID" id="1229284">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59PR3">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PR3"/>
    <dbReference type="EnsemblFungi" id="CR_05630W_A-T">
        <property type="protein sequence ID" value="CR_05630W_A-T-p1"/>
        <property type="gene ID" value="CR_05630W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646692"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05630WA"/>
    <dbReference type="CGD" id="CAL0000181153">
        <property type="gene designation" value="DBP8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05630W_A"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="Q59PR3"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="PRO" id="PR:Q59PR3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232283" description="ATP-dependent RNA helicase DBP8">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="247"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="440" mass="48832" checksum="5A2483E47C9368DB" modified="2005-04-26" version="1">MSFNDLGVAKWLSESLDAMKIYTPTAIQSACIPAILKGHDCIGGAKTGSGKTIAFAAPMLTQWSEDPFGIFGLILTPTRELALQIAEQFAALGANMNIKVAVVVGGEDFVQQTLALQRKPHFVIATPGRLADHILNSGEETISGLRRVKYLVLDEADRLLSNSFGSDLQRCFDVLPTSDKRQTLLFTATITDAVRALKEKPPTPGKPPVFMHEVETVDKVAIPSTLQISYVFVPSYVKEAYLNSILHLEQFKDSTAVIFVNRTTTAEVLRRMLRKLDFRVASLHSEMPQSERTNSLHRFKAGAARILIATDVASRGLDIPTVELVINFDIPADPDDFIHRVGRTARAGRKGDAVSIIGEKDIDRIQSIEERINKKMELLEDVNDDNVIKESLSATSVAKRESLMEMDKENFGERKKINRKKHGLDKVKPERVTKPKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QT6</accession>
    <name>Q59QT6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C503460CA</name>
        <name evidence="8" type="ordered locus">orf19.10160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712020.1">
        <property type="nucleotide sequence ID" value="XM_706927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QT6"/>
    <dbReference type="STRING" id="237561.Q59QT6"/>
    <dbReference type="GeneID" id="3646345"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503460CA"/>
    <dbReference type="CGD" id="CAL0000195544">
        <property type="gene designation" value="orf19.10160"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03460C_A"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="InParanoid" id="Q59QT6"/>
    <dbReference type="OMA" id="WNIWDIE"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016482540" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000195544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="337" mass="39885" checksum="297681738005683F" modified="2005-04-26" version="1">MKILYSFLMLFVVAFASLGDNLPEFQSCLYQCDCHVIPQSIFWSCPANCNYYCQQLITDQLESSNVPMVQFYGKWPFKRVLGVQEFFAMIFSIGNLYVNYKNLRIIYRQFKRNESEYKTMYVQYLILLIVTCIGWSFSVIFHFKDTTMSETLDYFGAFAIILCNLNAIVVRVFQLFKHRKKLIIWHTALVALYLYHVIRLKRNWDYSYNTLINIIVGVSAMILWCFHSWRVYRVYNQKRIIYNNSIQLLPYETKLLQKLSYVGMSLSSLIPLIPIFNNVMLLLGISLELNDFPPVARLVDAHALWHLVTIFPSIIWFDWNVWDIEMLKITNNSETKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2025-06-18" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RH5</accession>
    <accession>A0A1D8PQF8</accession>
    <name>HAT2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Histone acetyltransferase type B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HAT2</name>
        <name type="ordered locus">CAALFM_C604540CA</name>
        <name type="ORF">CaO19.2146</name>
        <name type="ORF">CaO19.9693</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712421.1">
        <property type="nucleotide sequence ID" value="XM_707328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RH5"/>
    <dbReference type="SMR" id="Q59RH5"/>
    <dbReference type="FunCoup" id="Q59RH5">
        <property type="interactions" value="1129"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59RH5"/>
    <dbReference type="EnsemblFungi" id="C6_04540C_A-T">
        <property type="protein sequence ID" value="C6_04540C_A-T-p1"/>
        <property type="gene ID" value="C6_04540C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645973"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604540CA"/>
    <dbReference type="CGD" id="CAL0000185853">
        <property type="gene designation" value="HAT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04540C_A"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="InParanoid" id="Q59RH5"/>
    <dbReference type="OMA" id="PHEEGCL"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="PRO" id="PR:Q59RH5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000221">
        <property type="term" value="P:negative regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001977">
        <property type="entry name" value="Histone acetyltransferase type B subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000227735" description="Histone acetyltransferase type B subunit 2">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with the histone H4 N-terminus" evidence="2">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="site" description="Important for interaction with HAT1" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P39984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="382" mass="42856" checksum="EC2E4DE6C2A4022E" modified="2005-04-26" version="1">MSEQPTEPLSIKEEYQLWRKNCRYMYEFVSETALMWPSLTIQWLPNYTTTNGLIDAKLLLGTHTSNQSANQLKVASTQLSADPNVKANSKIKTVQKLENNAEICRARYMPQDANIVATINGLGEVDLYNLDTETRYSHFAPHTKNGYGLSWNPKQKGLLVTGADDNFVCVTDTTTNKTTFKSDIQKDIVNDVKWHQFNGNLFASVSEDSHVYLFDARDNKVVSQYYAESSNGINSLAFSPFAENLVAIGNTSSNINLLDLRKLGENSGLLHTMMGHSEGITCMEFSPHHDGILATGSQDRRIIIWDLFKVGEEQQQEDAEDGCPELFMMHAGHTAGVSDLSWCPFKDWMIGSVADDNIVHLWEISKKLITNEEAEVDVSILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SJ6</accession>
    <name>Q59SJ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial 37S ribosomal protein MRPS17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C400660WA</name>
        <name evidence="4" type="ordered locus">orf19.11652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712630.1">
        <property type="nucleotide sequence ID" value="XM_707537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SJ6"/>
    <dbReference type="SMR" id="Q59SJ6"/>
    <dbReference type="FunCoup" id="Q59SJ6">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SJ6"/>
    <dbReference type="GeneID" id="3645755"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400660WA"/>
    <dbReference type="CGD" id="CAL0000180848">
        <property type="gene designation" value="orf19.11652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00660W_A"/>
    <dbReference type="HOGENOM" id="CLU_1246209_0_0_1"/>
    <dbReference type="InParanoid" id="Q59SJ6"/>
    <dbReference type="OMA" id="IRNKGQQ"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000180848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="246" mass="28909" checksum="4079AD5878548E6C" modified="2005-04-26" version="1">MARQNFVGVVISQGKMTKTVKVRVQGRVYDKRVDKEILTRKDYLVHDEGSICKEGDIVRIESIPKISKRKAFAIAEIKVNKGQQFAAYEEMAKKQVKLEEEKEAKKFIEHREKFSKIITQLDDLKKMDKLTHEITSNIEEDHTKLIEEINQIKEKYNIKSWPTTESTVDLGLNEPIFSDEKEKRLYFIQYILNELMNNAKYEEIRKSIVESKLKKSMEEVSKSIQKNVVRRYLLDTRNECPVPLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TS4</accession>
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            <fullName evidence="5 15">Chorismate mutase</fullName>
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        <name evidence="17 18" type="primary">ARO7</name>
        <name evidence="18" type="ordered locus">CAALFM_C111500CA</name>
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    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2021-07" db="PDB data bank">
            <title>Crystal structure of Aro7p chorismate mutase from Candida albicans, complex with L-Trp.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the Claisen rearrangement of chorismate to prephenate. Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707943.1"/>
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    <dbReference type="PDB" id="7RJ1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.16 A"/>
        <property type="chains" value="A/B/C/D=1-268"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TS4"/>
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    <dbReference type="FunCoup" id="Q59TS4">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q59TS4"/>
    <dbReference type="GeneID" id="3645337"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111500CA"/>
    <dbReference type="CGD" id="CAL0000179531">
        <property type="gene designation" value="ARO7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11500C_A"/>
    <dbReference type="eggNOG" id="KOG0795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057757_0_0_1"/>
    <dbReference type="InParanoid" id="Q59TS4"/>
    <dbReference type="OMA" id="FLDWALM"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
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        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="16">
        <location>
            <begin position="142"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000179531"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26774.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="7RJ1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30978" checksum="72E3E8266450ABFD" modified="2005-04-26" version="1">MDFMKPETVLDLANIRQALVRMEDTIVFDLIERSQFFSSPSVYEKNKYNIPNFDGTFLEWALLQLEVAHSQIRRYEAPDETPFFPDQLKTPILPPINYPKILAKYSDEINVNSEIMKFYVDEIVPQVSCGQGDQKENLGSASTCDIECLQAISRRIHFGKFVAEAKYQSDKPLYIKLILDKDVKGIENSITNSAVEQKILERLIVKAESYGVDPSLKFGQNVQSKVKPEVIAKLYKDWIIPLTKKVEIDYLLRRLEDEDVELVEKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q59X29</accession>
    <name>Q59X29_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome regulatory particle base subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">RPN10</name>
        <name evidence="6" type="ordered locus">CAALFM_C206150CA</name>
        <name evidence="5" type="ordered locus">orf19.11583</name>
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709180.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="CGD" id="CAL0000186311">
        <property type="gene designation" value="RPN10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06150C_A"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="InParanoid" id="Q59X29"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome regulatory subunit RPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000186311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="279" mass="30394" checksum="483F37CED40B3DB0" modified="2005-04-26" version="1">MVLEATMIAIDNSEYMRNGDFLTSRYEAQLTATEFIFQNKINSNPENTVGLLAYGGSGPQVLSTLTTDFGKILAGVHETKIQGENNFSSGIQVAALALKHRQNKVQQQRIIIFVGSPIKESEKELEKLAKKMKKNNVAVDIINFGEEGVNTAKLERFQSTINNHDNSHLVTISPGPRLLYEVVASSPILVEDGGFGAGVSGGDMDFFGGAGGAGDIIDPNMDPDLAMALRLSLEEEKARQEREAADRAKAEASTDLEKIDESKEDNNDKDKDVNMEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YH1</accession>
    <name>Q59YH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucosamine/galactosamine-6-phosphate isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C209970CA</name>
        <name evidence="8" type="ordered locus">orf19.8935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in regulation of tRNA subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714529.1">
        <property type="nucleotide sequence ID" value="XM_709436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YH1"/>
    <dbReference type="SMR" id="Q59YH1"/>
    <dbReference type="FunCoup" id="Q59YH1">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YH1"/>
    <dbReference type="GeneID" id="3643820"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209970CA"/>
    <dbReference type="CGD" id="CAL0000180100">
        <property type="gene designation" value="orf19.8935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09970C_A"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="Q59YH1"/>
    <dbReference type="OMA" id="KLAWCLP"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000017">
        <property type="entry name" value="6-phosphogluconolactonase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="113"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000180100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="347" mass="38619" checksum="A1832F4F7D75EB52" modified="2005-04-26" version="1">MTTTVPLIYSFPEFLGVADAVADHIITAQNQTLYNTTDLDQIELIKQRSGNTPSHTPRHSQSGIELPSTTASGALNTPLSRNGSSPKLNNNNGNTTTTSSSGRPKKEKKIQKKQEVRFKIAISGGSLIKILHQGLLPRQKYIEWDKWDIYFADERLVPFESPDSNYGQAKREIFDLITGDKKPRIFHVDESLIDDSQEAADEYEKQLINNFAKKDSVKLPLFDLFLLGCAPDGHIASLFPNHGEQLREKLAWVLPVSNAPSGPENRITLSIPVICHSARVTFVVEGLTKAPIIKTIMERPEKGLPSSIVNEGAAGRVSWFVDDDALNDLFDITKKKYKYLSIPEPSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-06-18" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZC8</accession>
    <accession>A0A1D8PHS0</accession>
    <accession>Q59Z64</accession>
    <name>FKHL1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Fork-head transcriptional regulator FHL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FHL1</name>
        <name type="ordered locus">CAALFM_C206830CA</name>
        <name type="ORF">CaO19.2236</name>
        <name type="ORF">CaO19.9778</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="PLoS Biol." volume="8" first="E1000329" last="E1000329">
            <title>Evolutionary tinkering with conserved components of a transcriptional regulatory network.</title>
            <authorList>
                <person name="Lavoie H."/>
                <person name="Hogues H."/>
                <person name="Mallick J."/>
                <person name="Sellam A."/>
                <person name="Nantel A."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="20231876"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.1000329"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="Eukaryot. Cell" volume="1" first="787" last="798">
            <title>A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans.</title>
            <authorList>
                <person name="Bensen E.S."/>
                <person name="Filler S.G."/>
                <person name="Berman J."/>
            </authorList>
            <dbReference type="PubMed" id="12455696"/>
            <dbReference type="DOI" id="10.1128/EC.1.5.787-798.2002"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="17508" last="17519">
            <title>The evolutionary rewiring of the ribosomal protein transcription pathway modifies the interaction of transcription factor heteromer Ifh1-Fhl1 (interacts with forkhead 1-forkhead-like 1) with the DNA-binding specificity element.</title>
            <authorList>
                <person name="Mallick J."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="23625919"/>
            <dbReference type="DOI" id="10.1074/jbc.M112.436683"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH IFH1 AND TBF1</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes (PubMed:20231876, PubMed:23625919). The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1 (PubMed:23625919).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with IFH1 and TBF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27684.1"/>
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        <property type="nucleotide sequence ID" value="XM_709734.2"/>
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        <property type="gene ID" value="C2_06830C_A"/>
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    <dbReference type="GeneID" id="3643493"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206830CA"/>
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    <dbReference type="PANTHER" id="PTHR42746">
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    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
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    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
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            <begin position="1"/>
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            <begin position="449"/>
            <end position="537"/>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="734"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="64"/>
            <end position="83"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZW4</accession>
    <accession>A0A1D8PFV3</accession>
    <name>YPI1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Type 1 phosphatases regulator YPI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YPI1</name>
        <name type="ordered locus">CAALFM_C114190CA</name>
        <name type="ORF">CaO19.7227</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709935.1"/>
    </dbReference>
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        <property type="gene ID" value="C1_14190C_A"/>
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    <dbReference type="HOGENOM" id="CLU_098333_3_0_1"/>
    <dbReference type="InParanoid" id="Q59ZW4"/>
    <dbReference type="OMA" id="AYEVQPH"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000333470" description="Type 1 phosphatases regulator YPI1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="124" mass="13981" checksum="0EE2F3A2FC2347BD" modified="2005-04-26" version="1">MSQQRENQRGIVSQTTTTTASPILKLRAQERQARDVSWDANVVDNEHLNKKKTKICCIFHPSDRNCDEEDSSSSSDSSSDSSDNEEDDKNTKIAPKSNNNKKKSKPNAYEVQPHYKNQSKVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A108</accession>
    <name>Q5A108_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C407150WA</name>
        <name evidence="2" type="ordered locus">orf19.10600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715398.1">
        <property type="nucleotide sequence ID" value="XM_710305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A108"/>
    <dbReference type="SMR" id="Q5A108"/>
    <dbReference type="STRING" id="237561.Q5A108"/>
    <dbReference type="GeneID" id="3642935"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407150WA"/>
    <dbReference type="CGD" id="CAL0000196526">
        <property type="gene designation" value="orf19.10600"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07150W_A"/>
    <dbReference type="eggNOG" id="ENOG502T57P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138100_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A108"/>
    <dbReference type="OrthoDB" id="4088185at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000196526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="179" mass="20761" checksum="12478565A450423B" modified="2005-04-26" version="1">MVCAHTHPPISGIFFFLLRKNCTPKLYHYFLTTNYMNGEEQVDNYDEFEINNELDFDIEEEIRKIMTLSPMSTPTSTFSPTDSISTVATEPETKANLDTISYVKSLMIDSSKLLGLYSTLKNTYLKLCKEYNYLLTKFNDNEKAKLQLIQENEELKQAMAELLQDRSSKKRRKSRKALA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A210</accession>
    <accession>A0A1D8PSA1</accession>
    <name>PGA34_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Predicted GPI-anchored protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGA34</name>
        <name type="ordered locus">CAALFM_CR02750CA</name>
        <name type="ORF">CaO19.10351</name>
        <name type="ORF">CaO19.2833</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="62" first="100" last="119">
            <title>The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans.</title>
            <authorList>
                <person name="Bennett R.J."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="16987174"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05367.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Eukaryot. Cell" volume="11" first="896" last="904">
            <title>Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo.</title>
            <authorList>
                <person name="Fanning S."/>
                <person name="Xu W."/>
                <person name="Solis N."/>
                <person name="Woolford C.A."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22544909"/>
            <dbReference type="DOI" id="10.1128/EC.00103-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text>Predicted GPI-anchored protein which may have a role during host infection.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2 3 4">Induced in biofilms and in oralpharyngeal candidasis. Repressed by alpha pheromone.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715764.2">
        <property type="nucleotide sequence ID" value="XM_710671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A210"/>
    <dbReference type="STRING" id="237561.Q5A210"/>
    <dbReference type="GlyCosmos" id="Q5A210">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CR_02750C_A-T">
        <property type="protein sequence ID" value="CR_02750C_A-T-p1"/>
        <property type="gene ID" value="CR_02750C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642579"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02750CA"/>
    <dbReference type="CGD" id="CAL0000179698">
        <property type="gene designation" value="PGA34"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02750C_A"/>
    <dbReference type="HOGENOM" id="CLU_1348755_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A210"/>
    <dbReference type="PRO" id="PR:Q5A210"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424937" description="Predicted GPI-anchored protein 34">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424938" description="Removed in mature form" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16987174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="21414038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22544909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="197" mass="19497" checksum="F36F239294681036" modified="2017-03-15" version="2" precursor="true">MKFTSLICSSILLIIPTVMADDASSDTTIINTITITKTLYTPEESSSLLSVQLESEASVASVASAASEAAASAASIASVASEASAASLASELSALAKVTEVKADVINNYNATINSTLSSSTIAPKISSSSSSSSSKKHESITSVITSSTKDNASAAVTTKTGSATSKAGAAAMAGPVPILTNSIFTAGLLALAAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A356</accession>
    <name>Q5A356_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_CR08410WA</name>
        <name evidence="11" type="ordered locus">orf19.13765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716246.1">
        <property type="nucleotide sequence ID" value="XM_711153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A356"/>
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    <dbReference type="STRING" id="237561.Q5A356"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR08410WA"/>
    <dbReference type="CGD" id="CAL0000175606">
        <property type="gene designation" value="orf19.13765"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_08410W_A"/>
    <dbReference type="eggNOG" id="KOG2785">
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    <dbReference type="OMA" id="QRYHMKT"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ribosomal large subunit binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
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        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000175606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="450" mass="51403" checksum="750F53C42D6B3C46" modified="2005-04-26" version="1">MSFMPSGSNPETASFTCNTCGVKFINAELQRQHMKTEWHRYNLKRRVAGLPSITAGVFAEKILTSKHLAKNENEDEYGFYVATRKKKTNGERQLTKKFLKSQKNRGRTEEVKLTIDGGREASPAASLTSDFSEFSLGDSDFHEVESIVTGSEINYTEESDFTDLEGELLSEEEEDDEEDAEEEANDSDGSSEAVESIPITHCFYCGLNNREIENNIKHMFNKHGLYIPERSYLVDPSGLLEYLSEVISLDYECLVCGFEGKNLESVRQHIASKGHCRIPYETKEEKLAISQFYDFSVEDEPKTQAKESTKKHVEFSDEAPSTIVVEYENQPGDNERGTGDNGINDNYELVYIDQSGVELTTPAGYRIGHRSMQRYYRQNLRSPREPTVAQTTQALVDTRLAPGLSPYYATKQEKETRRIENKTRNNVERKRNKTRRANYQKHYRDEILGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4X0</accession>
    <accession>A0A1D8PMX1</accession>
    <name>BRE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>E3 ubiquitin-protein ligase BRE1</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase BRE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">BRE1</name>
        <name type="ordered locus">CAALFM_C500210CA</name>
        <name type="ORF">CaO19.8591</name>
        <name type="ORF">CaO19.976</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716814.1">
        <property type="nucleotide sequence ID" value="XM_711721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4X0"/>
    <dbReference type="SMR" id="Q5A4X0"/>
    <dbReference type="FunCoup" id="Q5A4X0">
        <property type="interactions" value="947"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4X0"/>
    <dbReference type="EnsemblFungi" id="C5_00210C_A-T">
        <property type="protein sequence ID" value="C5_00210C_A-T-p1"/>
        <property type="gene ID" value="C5_00210C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641568"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500210CA"/>
    <dbReference type="CGD" id="CAL0000187022">
        <property type="gene designation" value="BRE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00210C_A"/>
    <dbReference type="eggNOG" id="KOG0978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019713_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A4X0"/>
    <dbReference type="OMA" id="ERHRACR"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="PRO" id="PR:Q5A4X0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140850">
        <property type="term" value="F:histone H2B C-terminal K residue ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000414">
        <property type="entry name" value="E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000055848" description="E3 ubiquitin-protein ligase BRE1">
        <location>
            <begin position="1"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="3">
        <location>
            <begin position="629"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="77"/>
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    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="136"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="224"/>
            <end position="446"/>
        </location>
    </feature>
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        <location>
            <begin position="477"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q07457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="681" mass="78522" checksum="82E6002053F50C6C" modified="2005-04-26" version="1">MAVDNEKKRSTPDSLNSPHAKKSKPMQELSESGPLTQADVVYFQKEAIWRQMIQYKQQMMSMRSELIRLQRESDASKHIVTVLTAWYEQILALFDELNSEETSDLLLAITKNDDEQLDLIRKKLSNLISSKVTFDSAKYEKVSGELALLSRQNEQMTEEKRSLGERIDELESKITELAKEHERAQSKTLKRLDSQRHIKTEEDEQSTTKEENPQPNGHHKENDKTAVVDSEELDNLKCELDKLKTANQLLVQQVEQLTKENQSLIQKSLNLENKLHNLEESDLEDNTYYKKIVKNNQSLQEQIGKLTKLNSSNVSRLNELERQQNDLKSVIEGEIIEENEKLKQQLQESENNLVRIRTTRDELLSKNNILTSQLQDQKTNESLVELNNVLSKRVESLTEERLEAIVGTPGTGKLEDLSQQELIHKISQLNNEIKEVELAFKQTREITLKKLTSSIDQENLTKKLTIEKNKADQKYFSAMRVKDSLTNENKLLKAQIAKSQDLIKNLNDLEKKYLNKIDLLSNQLVDFRIIKENSLAENSKLHDELKTLNIAQDALHQEVERVNAKLESTLKEHTDLQESNKKRELELAKLQKQLQSTENILQKYKTNNTNSLLQEDEQQLEALRSIAKCSVCSKNWKDTAITVCGHVFCSKCTQERLAARLRRCPSCNRGFSANDLLSIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5F3</accession>
    <accession>Q3MP29</accession>
    <name>Q5A5F3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C703260CA</name>
        <name evidence="1" type="ordered locus">orf19.12594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716952.1">
        <property type="nucleotide sequence ID" value="XM_711859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5F3"/>
    <dbReference type="STRING" id="237561.Q5A5F3"/>
    <dbReference type="GeneID" id="3641366"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703260CA"/>
    <dbReference type="CGD" id="CAL0000198382">
        <property type="gene designation" value="orf19.12594"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03260C_A"/>
    <dbReference type="eggNOG" id="ENOG502RXMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054132_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A5F3"/>
    <dbReference type="OMA" id="VMVFLFR"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000198382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26499" checksum="6E240931A9952D6F" modified="2005-04-26" version="1">MSIITNPLYRPLFEVLKSARNGIVYGGKLRFSHALVINLLYRSGPIVPRLKSVLEATKDHAQVLAAFAIIYKACVMILKQDAFLGDKNLGLIKFIAGSFGSWIVYSQHFNFFHGGITHQITLYCFSRVVLALSKILLDKYLNCFQPGFRNYQGELIHYKDLNNQQQKKLKNIVYNKSWKYFAVLTWGLVMLIYDYQPQYLQSSLRHSMAYIYDVEMDTWSNWREFLGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5U6</accession>
    <accession>A0A1D8PLZ1</accession>
    <name>PGA30_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cell wall protein PGA30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>GPI-anchored protein 30</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>LDG family protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PGA30</name>
        <name type="synonym">LDG6</name>
        <name type="ordered locus">CAALFM_C404070CA</name>
        <name type="ORF">CaO19.12763</name>
        <name type="ORF">CaO19.5303</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Proteomics" volume="8" first="3871" last="3881">
            <title>A study of the Candida albicans cell wall proteome.</title>
            <authorList>
                <person name="Castillo L."/>
                <person name="Calvo E."/>
                <person name="Martinez A.I."/>
                <person name="Ruiz-Herrera J."/>
                <person name="Valentin E."/>
                <person name="Lopez J.A."/>
                <person name="Sentandreu R."/>
            </authorList>
            <dbReference type="PubMed" id="18712765"/>
            <dbReference type="DOI" id="10.1002/pmic.200800110"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Antimicrob. Agents Chemother." volume="57" first="873" last="886">
            <title>Milbemycins: more than efflux inhibitors for fungal pathogens.</title>
            <authorList>
                <person name="Silva L.V."/>
                <person name="Sanguinetti M."/>
                <person name="Vandeputte P."/>
                <person name="Torelli R."/>
                <person name="Rochat B."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="23208712"/>
            <dbReference type="DOI" id="10.1128/AAC.02040-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <topology evidence="4">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment.</text>
    </comment>
    <comment type="PTM">
        <text>The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SRP1/TIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717106.1">
        <property type="nucleotide sequence ID" value="XM_712013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5U6"/>
    <dbReference type="STRING" id="237561.Q5A5U6"/>
    <dbReference type="GlyCosmos" id="Q5A5U6">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_04070C_A-T">
        <property type="protein sequence ID" value="C4_04070C_A-T-p1"/>
        <property type="gene ID" value="C4_04070C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641227"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404070CA"/>
    <dbReference type="CGD" id="CAL0000200830">
        <property type="gene designation" value="PGA30"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04070C_A"/>
    <dbReference type="eggNOG" id="ENOG502SXWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083354_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A5U6"/>
    <dbReference type="OMA" id="TITEKCV"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="PRO" id="PR:Q5A5U6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424727" description="Cell wall protein PGA30">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424728" description="Removed in mature form" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18712765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23208712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="277" mass="28389" checksum="9E084BDAC1316C83" modified="2005-04-26" version="1" precursor="true">MKYFTIATVLTLASSALAAIRDVQLFAQSSNEEINNLGLISRREGAGVNYLFLASGAETLKFDDETFTIFSELQTGSTTARQSLVVSGGVVQLSVSGQPLHVEIAEDGSVKFAGSDSVAAAKNINDPYNYSKDSFAVVTNGGEGSIPFKIIAKFIGGGKSSSVTKHTEAPTTSPVYSNKTVTVFTTYCPESTTITLTICSEVCTPTVIETSGSVTVSSVLPSSSTEAPPKTSVAAPSTTAEAQTTAPVTSYEGGANEIVGGGSMAIALAAAAIGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A750</accession>
    <name>Q5A750_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">TKL1</name>
        <name evidence="18" type="ordered locus">CAALFM_C108320WA</name>
        <name evidence="17" type="ordered locus">orf19.12578</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717648.1">
        <property type="nucleotide sequence ID" value="XM_712555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A750"/>
    <dbReference type="SMR" id="Q5A750"/>
    <dbReference type="FunCoup" id="Q5A750">
        <property type="interactions" value="832"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A750"/>
    <dbReference type="GeneID" id="3640767"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108320WA"/>
    <dbReference type="CGD" id="CAL0000174068">
        <property type="gene designation" value="TKL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08320W_A"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A750"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="353"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000174068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW26470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="677" mass="73772" checksum="63085FEBE3A1350F" modified="2005-04-26" version="1">MPSLDELTISTIRGLSVDAVSAANSGHPGAPLGLAPAAHVVWQKMKFNPKDPNWINRDRFVLSNGHACALLYSLLVLYKFELTVDDLKQFRQLGSKTPGHPEATDTAGVEVTTGPLGQGISNAVGIAIAQKQFAATYNKPDITLSDSYVYTFVGDGCLMEGVSSETSSLAGHLQLNNLIAFWDDNRISIDGDTAVSFTENVPDRYRAYGWNVLEVPDANTNIEAIAAAVDEAKKSTDKPTLIRLVTTIGYGSLKQGSHDVHGSPLKPDDIKQLKKSWGFKEDVDFFIPEEVSEYLAKHVSENQKVQKEWEAKLAEYKKKYPTEGAEIQRRLDGKLPEGWKEYLPKYTPADKPLATRKLSENVINALHGKIPEFIGGSADLTGSNLTRAEGSVDFQPPSTGLGNYDGVYIRYGVREHGMGAIMNGIAAFGANYKNYDGTFLNFVSYAAGALRLSALSHHPVIWVATHDSIGLGEDGPTHQPIETLAHFRAIPNLSVWRPADGNEVSAAYAAAIESTSHPSVIALTRQNLPQLEGSSIENALKGGYTLVKKDNPDVIIVSSGSEVSISVAASEELAKQGVKANVVSLPDFFTFDQQSDEYRLSVLPDGVPILSVEVMSTFGWSKYSHEQFGLNRFGASGKAADLYKYFEFTPEGIAERAQKTIKYYEGKQLLSPLDRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7M0</accession>
    <name>Q5A7M0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C300230CA</name>
        <name evidence="2" type="ordered locus">orf19.5446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717818.1">
        <property type="nucleotide sequence ID" value="XM_712725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7M0"/>
    <dbReference type="GeneID" id="3640557"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300230CA"/>
    <dbReference type="CGD" id="CAL0000193187">
        <property type="gene designation" value="orf19.5446"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00230C_A"/>
    <dbReference type="HOGENOM" id="CLU_1610528_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A7M0"/>
    <dbReference type="OrthoDB" id="5593167at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000193187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="165" mass="18320" checksum="261B594E3F637149" modified="2005-04-26" version="1">MYILINTIQELNYSIWSTSVLSFHSGLVTAILWWWYNGGIGGMLRRKITLWNPFKSSLVRYTACSYIGTANTSSNSSNVNPLVSGKNHNTKKNPMTFHAAYQPKAPVGVNAFCNRGHVNANIKLKNQQVAVAQLIPKSRMYNGNASAEYVNGTGPSELEYIAEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AC02</accession>
    <name>Q5AC02_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lys14p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LYS14</name>
        <name evidence="6" type="ordered locus">CAALFM_C602750CA</name>
        <name evidence="5" type="ordered locus">orf19.12994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719111.1">
        <property type="nucleotide sequence ID" value="XM_714018.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AC02"/>
    <dbReference type="FunCoup" id="Q5AC02">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AC02"/>
    <dbReference type="GeneID" id="3639217"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602750CA"/>
    <dbReference type="CGD" id="CAL0000176046">
        <property type="gene designation" value="LYS14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02750C_A"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014489_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AC02"/>
    <dbReference type="OMA" id="YWFVSFE"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="PHI-base" id="PHI:2862"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000101">
        <property type="entry name" value="Transcription factor with zinc cluster DNA-binding motif, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000176046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="592" mass="67303" checksum="E519B99068007255" modified="2005-04-26" version="1">MSQSPSSLSPATASSSGVNSPSDQPPLPPRVRKSYSRNGCRECKRRKIRCPEEKPYCSTCVRLGKQCSYPLAGEKVLRISRRLIKEEIENMGKSTQFLPVQYDIPRRIKPQTQSVIKPSPLNIENLINSNDFLNGADLNVLTADLNNLVSDIIEVSNIPILEEDFQFDFLNEPIIVEQITKNVPIDYIKLPRKHEQLYWEEFYNNFAQIIEPFQAYDTKTKKTSNPARDIILQTAATEPFLLAAILAEGANTCYLKYKRPEDERAYGAYLSKCLKLLEPARETDINANIEAVLLTLLLLTAATATSQTQKWRPHLMGAKSLLLKAINQNVSKKFVFCKYWFVSIEILAGLSTNLGGTLQTDAEIDQLVTPGNEFEIEVLRDLGIISDQGFNILMGYDNTCLACFRDLLKILNKKRLNMYIDTMSYVKLLSDFYNQANIVYIDSRGVIAENELTRYVPGLPIEELRINNASYWISWQDISHQSYVLSSLIMILTRFFVIDVSGLVDKVIQFIHYLNQFSDVQQHASPYLLLMIQWPLLVTGLSTTKLEQRHLLLKYFSMVGQIGAAAANVSIQILLKHWKGTIDIENDDTLIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2025-04-09" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD05</accession>
    <accession>A0A1D8PG54</accession>
    <name>SOD4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cell surface superoxide dismutase [Cu-Zn] 4</fullName>
            <ecNumber>1.15.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GPI-anchored protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SOD4</name>
        <name type="synonym">PGA2</name>
        <name type="synonym">SOD32</name>
        <name type="ordered locus">CAALFM_C200660CA</name>
        <name type="ORF">CaO19.2062</name>
        <name type="ORF">CaO19.9609</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
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                <person name="Muzzey D."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="5">
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            <title>Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins.</title>
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            <dbReference type="PubMed" id="15302828"/>
            <dbReference type="DOI" id="10.1128/EC.3.4.955-965.2004"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Mol. Biol. Cell" volume="15" first="456" last="467">
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            <authorList>
                <person name="Martchenko M."/>
                <person name="Alarco A.M."/>
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                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="14617819"/>
            <dbReference type="DOI" id="10.1091/mbc.E03-03-0179"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="J. Antimicrob. Chemother." volume="55" first="663" last="673">
            <title>Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans.</title>
            <authorList>
                <person name="Sigle H.C."/>
                <person name="Thewes S."/>
                <person name="Niewerth M."/>
                <person name="Korting H.C."/>
                <person name="Schafer-Korting M."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="15790671"/>
            <dbReference type="DOI" id="10.1093/jac/dki089"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2005" name="Eukaryot. Cell" volume="4" first="1654" last="1661">
            <title>Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance.</title>
            <authorList>
                <person name="Westwater C."/>
                <person name="Balish E."/>
                <person name="Schofield D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16215173"/>
            <dbReference type="DOI" id="10.1128/EC.4.10.1654-1661.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2008" name="Microbiology" volume="154" first="510" last="520">
            <title>Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions.</title>
            <authorList>
                <person name="Sosinska G.J."/>
                <person name="de Groot P.W."/>
                <person name="Teixeira de Mattos M.J."/>
                <person name="Dekker H.L."/>
                <person name="de Koster C.G."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="18227255"/>
            <dbReference type="DOI" id="10.1099/mic.0.2007/012617-0"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="240" last="252">
            <title>Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance.</title>
            <authorList>
                <person name="Frohner I.E."/>
                <person name="Bourgeois C."/>
                <person name="Yatsyk K."/>
                <person name="Majer O."/>
                <person name="Kuchler K."/>
            </authorList>
            <dbReference type="PubMed" id="19019164"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06528.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2010" name="Mol. Microbiol." volume="78" first="331" last="343">
            <title>Temporal anatomy of an epigenetic switch in cell programming: the white-opaque transition of C. albicans.</title>
            <authorList>
                <person name="Lohse M.B."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="20735781"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2010.07331.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2011" name="Antimicrob. Agents Chemother." volume="55" first="4033" last="4037">
            <title>Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole.</title>
            <authorList>
                <person name="Bink A."/>
                <person name="Vandenbosch D."/>
                <person name="Coenye T."/>
                <person name="Nelis H."/>
                <person name="Cammue B.P."/>
                <person name="Thevissen K."/>
            </authorList>
            <dbReference type="PubMed" id="21746956"/>
            <dbReference type="DOI" id="10.1128/AAC.00280-11"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E28830" last="E28830">
            <title>Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione.</title>
            <authorList>
                <person name="Zhu J."/>
                <person name="Krom B.P."/>
                <person name="Sanglard D."/>
                <person name="Intapa C."/>
                <person name="Dawson C.C."/>
                <person name="Peters B.M."/>
                <person name="Shirtliff M.E."/>
                <person name="Jabra-Rizk M.A."/>
            </authorList>
            <dbReference type="PubMed" id="22205973"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0028830"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology>Lipid-anchor</topology>
            <topology>GPI-anchor</topology>
        </subcellularLocation>
        <text evidence="4">Covalently-linked GPI-modified cell wall protein (GPI-CWP).</text>
    </comment>
    <comment type="induction">
        <text evidence="5 6 8 10">Induced by farnesol and ciclopirox. Expression is higher in opaque cells compared to white cells.</text>
    </comment>
    <comment type="PTM">
        <text>The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719509.1">
        <property type="nucleotide sequence ID" value="XM_714416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD05"/>
    <dbReference type="SMR" id="Q5AD05"/>
    <dbReference type="STRING" id="237561.Q5AD05"/>
    <dbReference type="GlyCosmos" id="Q5AD05">
        <property type="glycosylation" value="9 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C2_00660C_A-T">
        <property type="protein sequence ID" value="C2_00660C_A-T-p1"/>
        <property type="gene ID" value="C2_00660C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638888"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200660CA"/>
    <dbReference type="CGD" id="CAL0000184565">
        <property type="gene designation" value="SOD4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00660C_A"/>
    <dbReference type="eggNOG" id="ENOG502S5NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063073_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AD05"/>
    <dbReference type="OMA" id="FTYHIHV"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="PRO" id="PR:Q5AD05"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071451">
        <property type="term" value="P:cellular response to superoxide"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0049">Antioxidant</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424634" description="Cell surface superoxide dismutase [Cu-Zn] 4">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424635" description="Removed in mature form" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15302828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15790671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="16215173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="19019164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="20735781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="21746956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="22205973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="15302828"/>
        </source>
    </evidence>
    <sequence length="232" mass="23726" checksum="CD945181DFC15842" modified="2005-04-26" version="1" precursor="true">MKYLSIISIVALALAGDSPISTDSKGKAPLVARFKKTSKSDIEGTIKFEPANNGTVLVSVDLTGLPSGVGPYPYHVHEKPVPESKNCTATGMHFNPFNGSTTAKTPAALELGDLSGRHGNITSESFEVEYDDSYISLNKDSKAYIGGLSIVVHSNNNTRLNCANITTLDEGDDTASAATWSNSSSSSSSSSKNSTNGSSGSSTSASQGSGAGRAEISGFLAAGIAGVVAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADQ3</accession>
    <name>Q5ADQ3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C307120WA</name>
        <name evidence="7" type="ordered locus">orf19.14080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719884.1">
        <property type="nucleotide sequence ID" value="XM_714791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADQ3"/>
    <dbReference type="SMR" id="Q5ADQ3"/>
    <dbReference type="STRING" id="237561.Q5ADQ3"/>
    <dbReference type="GeneID" id="3638441"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307120WA"/>
    <dbReference type="CGD" id="CAL0000177945">
        <property type="gene designation" value="orf19.14080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07120W_A"/>
    <dbReference type="eggNOG" id="ENOG502S8GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076653_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADQ3"/>
    <dbReference type="OMA" id="YIEIWRS"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.310">
        <property type="entry name" value="Protein HRI1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000177945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="245" mass="28146" checksum="A4EA64F62425994D" modified="2005-04-26" version="1">MVLSTRVSIQWPPKEAEEKTSTLALTTPANNYVDIRIFKTQYPCLNSTLPLPFTQVFELGLAGKEIPLDNDKIKFDNYISTLALQQSIESGLPIFSIDVDIGHFSNYGLDGDRKETGEMKNSEGIIAPYIEIWRSLDPLKHTPQTEVRENTENEPMKTKIKMNVFTLKLMDHLGVLIRIGNWIQGIIQEGNSIHVIRSWYNENLQQWCNLIEYGNSDAFPIQFNGDIDDVVKVRNGWKWKCIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADR2</accession>
    <name>Q5ADR2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">PRO2</name>
        <name evidence="14" type="ordered locus">CAALFM_C307220CA</name>
        <name evidence="13" type="ordered locus">orf19.14071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719875.1">
        <property type="nucleotide sequence ID" value="XM_714782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADR2"/>
    <dbReference type="SMR" id="Q5ADR2"/>
    <dbReference type="FunCoup" id="Q5ADR2">
        <property type="interactions" value="934"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADR2"/>
    <dbReference type="GeneID" id="3638532"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307220CA"/>
    <dbReference type="CGD" id="CAL0000189309">
        <property type="gene designation" value="PRO2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07220C_A"/>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ADR2"/>
    <dbReference type="OMA" id="KTQRYGT"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000189309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="446" mass="49120" checksum="BBC7F4548D7FAA08" modified="2005-04-26" version="1">MTAETIAKAANSAFASLKTLTNDQRSLALQKIHDALLTNKDKILESNKLDMENAQSQNLSSSLIKRLDLSNPGKYDSMLQGILDVAQLPDPMGKITLAKKLDEGLNLYRVTAPIGVLLIIFESRPEVIANITALAIKSGNSAILKGGKESYQTFKIMSEIINQTLQIETDVPRDAIQLIQSREDVADLLNQDKYIDLVIPRGSNELVRNIKSNTKIPVLGHADGICSIYVDEKFDIIKAKKIIVDSKTNYPAGCNAVEQLLINSHIPQQQIIEILQILIAAKVTIHVTPEIKQIISSGDNININIKGDDYIKDVEADSFDKEYLSFDISVKLVDNVDEAIKHINEHSSKHTECIITEDKAIAEKFLKSIDSAGIYWNASTRFADGFRYGFGTEVGISTNKIHARGPVGLEGLMSYQYQLKGDGHIVGEYVGGGGNKLFIHEDLSTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-09-13" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADS0</accession>
    <accession>O74274</accession>
    <name>UBI4P_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Polyubiquitin</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>Ubiquitin</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="primary">UBI4</name>
        <name type="synonym">UBI1</name>
        <name type="ordered locus">orf19.14063</name>
        <name type="ORF">CAALFM_C307270CA</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Fungal Genet. Biol." volume="39" first="70" last="81">
            <title>Depletion of polyubiquitin encoded by the UBI4 gene confers pleiotropic phenotype to Candida albicans cells.</title>
            <authorList>
                <person name="Roig P."/>
                <person name="Gozalbo D."/>
            </authorList>
            <dbReference type="PubMed" id="12742065"/>
            <dbReference type="DOI" id="10.1016/s1087-1845(03)00004-5"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="79" first="1574" last="1593">
            <title>Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans.</title>
            <authorList>
                <person name="Leach M.D."/>
                <person name="Stead D.A."/>
                <person name="Argo E."/>
                <person name="MacCallum D.M."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="21269335"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07542.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5 6">Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Involved in the negative control of switching, as well as in maintaining the yeast cell morphology (PubMed:12742065, PubMed:21269335).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6">Confers pleiotropic effects like an increased sensitivity to mild heat shock, increased formation of colony morphology variants and induction of hyphal and pseudohypal development (PubMed:12742065). Induces cell cycle defects, as well as sensitivity to thermal, oxidative and cell wall stresses. Rapidly lose viability under starvation conditions (PubMed:21269335).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Ubiquitin is encoded by several different genes. UBI3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. UBI4 is a polyprotein containing 3 exact head to tail repeats of ubiquitin.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719867.1">
        <property type="nucleotide sequence ID" value="XM_714774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADS0"/>
    <dbReference type="SMR" id="Q5ADS0"/>
    <dbReference type="FunCoup" id="Q5ADS0">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADS0"/>
    <dbReference type="EnsemblFungi" id="C3_07270C_A-T">
        <property type="protein sequence ID" value="C3_07270C_A-T-p1"/>
        <property type="gene ID" value="C3_07270C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638432"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307270CA"/>
    <dbReference type="CGD" id="CAL0000186339">
        <property type="gene designation" value="UBI4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07270C_A"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADS0"/>
    <dbReference type="OMA" id="MSDEHTL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070726">
        <property type="term" value="P:cell wall assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000458633" description="Ubiquitin">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000458634" description="Ubiquitin">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000458635" description="Ubiquitin">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000458636">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like 1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like 2" evidence="4">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like 3" evidence="4">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0CG47"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P0CG63"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12742065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21269335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="229" mass="25781" checksum="FB38C09C461F7F05" modified="2005-04-26" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADX0</accession>
    <name>Q5ADX0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA repair protein RAD4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RAD4</name>
        <name evidence="12" type="ordered locus">CAALFM_C307660WA</name>
        <name evidence="11" type="ordered locus">orf19.14014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Weissman J.S."/>
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            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000180754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="658" mass="75272" checksum="41538DD69659175A" modified="2005-04-26" version="1">MAEDMDSADTQVGDVDSSSNASLPEPSKESSRETTPESVPTNDQSDRPKPKKRLTLQERLAQAAKGKKKPSSTTPTSLSRTTSNEDQKPDLDLQMEIERLKLENSALTKKLNHKSNFDKERNDLIAKLASKDETIEQLRKEGEALSLKELKLNESIKKLKLANQDLEENIRDYSVKSEESSMKLEELTDFLKTHKFKTIDQVVSKYEEVVKELEVAKAGLENSHTWETKYNELVVSHEEANAAKKELLKETNEVKIELNMLKRQHKLEIESKNATIKELKSQMSASKQSFAQEISRLEDKIETLRLENESNETVSENVNEDGKVDFDEFSKLSEAHRILQKQYLSSQENWKAIESNLSLKVDNLSSSVESLKKSKHKLTQDLAKVNNSMHLQLKEMEKLEQDKIKLQEERNQLQLTVEMKENEIVEITEKFEKFKGIYNQERAALNSKIQSLNDKIKEEKRPERLNLIRDNSVSSGFSWDNEIKLGESSTTPAINRDFSTFLDRNISSSSFTEIGDDIDDREQYSFTGQLAPPVGGGVPASSHSNNIQLVNKMSSNIRRLEIELNTLKDEYSKISTEKEKVEQELLESLKLTDEIKLLHSELDSLKSVIKDKEIQEQRMLELIGEKSEQVEELKADVVDLKELCKLQVQQLVEQSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEF9</accession>
    <name>Q5AEF9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DAL5</name>
        <name evidence="9" type="ordered locus">CAALFM_C303120CA</name>
        <name evidence="8" type="ordered locus">orf19.7941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720004.1">
        <property type="nucleotide sequence ID" value="XM_714911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEF9"/>
    <dbReference type="SMR" id="Q5AEF9"/>
    <dbReference type="FunCoup" id="Q5AEF9">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AEF9"/>
    <dbReference type="GeneID" id="3638401"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303120CA"/>
    <dbReference type="CGD" id="CAL0000186369">
        <property type="gene designation" value="DAL5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03120C_A"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="Q5AEF9"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015124">
        <property type="term" value="F:allantoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015719">
        <property type="term" value="P:allantoate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042938">
        <property type="term" value="P:dipeptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042939">
        <property type="term" value="P:tripeptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000186369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="525" mass="58679" checksum="AEE94F332BC7C2DD" modified="2005-04-26" version="1">MTEKKELENQTNIQPIISFTKEDIEDNKPHVLTTIISPSGKEIAITNDVDQAMKLALEHKGETIEVDSVQASKLLRKIDLYLLPVMCLLYCFQFMDKLTTSYASVLGLRKELKMQGDMYSWTATAFYLGYLVFEFPASMLLQRFPVAKTVSVFIILWGMILALHSVPQYPGFVALRTILGMLESSVTPAFTIITSQWYRKEEQFLRTAWWFASNGIGTIVGSAIAYGLFKNNGNYSLPAWKLVFVVTGCLTIFLGFIIMVHIPDTPAGAWFLTDEEKLMVVERIRTNQQGFGNTHFKKHQFIEALTDHRTWLFFLFALSGNIPNGGLTSFGTILLNEDFGYTPSKSLLIQMPQGAVEIVGCVLFAWVCKFFPSRMLMGIITTSIAVLANCLLAFCKGTSARLAGFYLNLLGPLGFICCLSCVSSNVAGHTKKVTTNAMFLIAYCVGNLIGPQTFISTQAPGYTGAKVAIVVCGFVSLFILIAIYVSYYIENKKRNSRPPVDMSHIENYEFADLTDKENPNFRYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFB3</accession>
    <name>Q5AFB3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">TYS1</name>
        <name evidence="15" type="ordered locus">CAALFM_C402980WA</name>
        <name evidence="14" type="ordered locus">orf19.10209</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720447.1">
        <property type="nucleotide sequence ID" value="XM_715354.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFB3"/>
    <dbReference type="SMR" id="Q5AFB3"/>
    <dbReference type="FunCoup" id="Q5AFB3">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFB3"/>
    <dbReference type="GeneID" id="3637870"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402980WA"/>
    <dbReference type="CGD" id="CAL0000188062">
        <property type="gene designation" value="TYS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02980W_A"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AFB3"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000188062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW29063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="409" mass="44986" checksum="AB72EE531A608ECF" modified="2005-04-26" version="1">MTVITDPVEQYNLITKGLQETLNGQIIKDVLEKENRPVKIYWGTAPTGKPHCGYFVPMIKLAHFLKAGCEVTVLLADLHAFLDNMKAPLEVVKYRAKYYEFVVKAILKSINVPIERLKFVVGSSYQKGGDYVMDLFKLSNIVSQNDAKRAGADVVKQVANPLLSGLIYPLMQAIDEEHLGVDAQFGGVDQRKIFVLAEENLPSIGYKKRAHLMNPMVPGLGQGGKMSASDPNSKIDIIEEPKVVKKKVNSAYCAPGELKDNGLIAFIEYVIQPIAELKTGVEGAFKLDIDRPEKYGGPLSYDSIEQLKADFVDGKLAPPDLKSGVADKINELLAPIRAEFESSEEFQVAQKNGYPVEKPKQEKKKKVKKIGTRYPGTVSGGDSADTPANSNDGEKAEEKKSAEEKPTTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFC2</accession>
    <accession>A0A1D8PLQ5</accession>
    <name>PGA54_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Predicted GPI-anchored protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGA54</name>
        <name type="ordered locus">CAALFM_C403070WA</name>
        <name type="ORF">CaO19.10200</name>
        <name type="ORF">CaO19.2685</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Cell. Microbiol." volume="9" first="2938" last="2954">
            <title>In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination.</title>
            <authorList>
                <person name="Zakikhany K."/>
                <person name="Naglik J.R."/>
                <person name="Schmidt-Westhausen A."/>
                <person name="Holland G."/>
                <person name="Schaller M."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="17645752"/>
            <dbReference type="DOI" id="10.1111/j.1462-5822.2007.01009.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2913" last="2925">
            <title>Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.</title>
            <authorList>
                <person name="Garcia-Sanchez S."/>
                <person name="Mavor A.L."/>
                <person name="Russell C.L."/>
                <person name="Argimon S."/>
                <person name="Dennison P."/>
                <person name="Enjalbert B."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15814841"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-01-0071"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="1018" last="1032">
            <title>Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Enjalbert B."/>
                <person name="Smith D.A."/>
                <person name="Cornell M.J."/>
                <person name="Alam I."/>
                <person name="Nicholls S."/>
                <person name="Brown A.J.P."/>
                <person name="Quinn J."/>
            </authorList>
            <dbReference type="PubMed" id="16339080"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-06-0501"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Lipid-anchor</topology>
            <topology>GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2 3 4">Expression is induced during infection of reconstituted human oral epithelium. Expression is repressed by HOG1 and regulated by TEC1, EGF1, NTD80, ROB1, BRG1, and SSN6.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720438.2">
        <property type="nucleotide sequence ID" value="XM_715345.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFC2"/>
    <dbReference type="BioGRID" id="1221023">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFC2"/>
    <dbReference type="GlyCosmos" id="Q5AFC2">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_03070W_A-T">
        <property type="protein sequence ID" value="C4_03070W_A-T-p1"/>
        <property type="gene ID" value="C4_03070W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637929"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403070WA"/>
    <dbReference type="CGD" id="CAL0000192137">
        <property type="gene designation" value="PGA54"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03070W_A"/>
    <dbReference type="HOGENOM" id="CLU_792252_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AFC2"/>
    <dbReference type="OMA" id="YCVPTTV"/>
    <dbReference type="PRO" id="PR:Q5AFC2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000429956" description="Predicted GPI-anchored protein 54">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000429957" description="Removed in mature form" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="1">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15814841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16339080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17645752"/>
        </source>
    </evidence>
    <sequence length="342" mass="36033" checksum="6D4C53A892A6CBEC" modified="2017-05-10" version="2" precursor="true">MRANYLLLLAATAVQAAPFIKRYENTTAPASQLSTSLADGSTTILGSSSSSVEEDETITSTIVQYVTVTSSDTTYVSATNTLTTTLTTKPTPVITTEAEDDEEDNETITSTILQYVTVTSSDTTYVSATNTLTTTLTTKAAEATESEEEENETITSTILQYVTVTSSDTTYVSATNTITSVLTTKAAVSTNDVSENAKAATTEDDGETTTSTITSIVTITDANGNTEVLTEVAAETSGAEDASYCVPTTVTVTVTAEQTSEVVSTIVHTTQVPLTAEFTLDDTTTTLTSWVDLTSTDLVTITSTSSVYDSYSTGASQSHPISSYSNYTISDYAPPISSYYSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-01" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFI4</accession>
    <accession>A0A1D8PQK9</accession>
    <accession>Q3MPU3</accession>
    <name>DFI1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell-surface associated glycoprotein DFI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Defective in filamentous invasion protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DFI1</name>
        <name type="ordered locus">CAALFM_C700360WA</name>
        <name type="ORF">CaO19.7084</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E76239" last="E76239">
            <title>Calmodulin binding to Dfi1p promotes invasiveness of Candida albicans.</title>
            <authorList>
                <person name="Davis T.R."/>
                <person name="Zucchi P.C."/>
                <person name="Kumamoto C.A."/>
            </authorList>
            <dbReference type="PubMed" id="24155896"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0076239"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>CALMODULIN-BINDING</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="Mol. Microbiol." volume="76" first="733" last="748">
            <title>A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid medium.</title>
            <authorList>
                <person name="Zucchi P.C."/>
                <person name="Davis T.R."/>
                <person name="Kumamoto C.A."/>
            </authorList>
            <dbReference type="PubMed" id="20384695"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2010.07137.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF GLY-273 AND GLY-277</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>GLYCOSYLATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Cell-surface associated glycoprotein that acts as a plasma membrane receptor-type protein which senses the presence of matrix. Binds to calmodulin in response to environmental conditions and initiates a signaling cascade that activates CEK1, thus promoting invasive filamentation. Involved in the maintenance of the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell septum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Cell wall</location>
        </subcellularLocation>
        <text evidence="4">A part becomes cross-linked to the cell wall and thus links the cell wall to the plasma membrane and cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The GxxxG glycophorin motif in the transmembrane domain is required for CEK1 activation and subsequent invasive filamentation on agar medium.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The cytoplasmic C-terminal calmodulin-binding motif (residues 301 to 317) is important for CEK1 activation and subsequent invasive filamentation on agar medium.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cross-linked to the carbohydrate polymers of the cell wall.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">O-glycosylated by MNT1 and MNT2. Also N-glycosylated.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Shows defects in invasion of agar medium and attenuated virulence in a murine model of disseminated candidiasis. Leads to hypersensibility to the glucan synthase inhibitor capsofungin and the cell wall disturbing agents Congo red and calcofluor white.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MID2 like cell wall stress sensor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720375.1">
        <property type="nucleotide sequence ID" value="XM_715282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFI4"/>
    <dbReference type="SMR" id="Q5AFI4"/>
    <dbReference type="STRING" id="237561.Q5AFI4"/>
    <dbReference type="GlyCosmos" id="Q5AFI4">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C7_00360W_A-T">
        <property type="protein sequence ID" value="C7_00360W_A-T-p1"/>
        <property type="gene ID" value="C7_00360W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638038"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700360WA"/>
    <dbReference type="CGD" id="CAL0000194442">
        <property type="gene designation" value="DFI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00360W_A"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823854_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AFI4"/>
    <dbReference type="OMA" id="LDQYHKP"/>
    <dbReference type="OrthoDB" id="4026433at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000431721" description="Cell-surface associated glycoprotein DFI1">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="7">
        <location>
            <begin position="43"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Glycophorin A" evidence="6">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Calmodulin-binding" evidence="5">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impairs CEK1 activation and invasive filamentation; when associated with L-277." evidence="4">
        <original>G</original>
        <variation>L</variation>
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impairs CEK1 activation and invasive filamentation; when associated with L-273." evidence="4">
        <original>G</original>
        <variation>L</variation>
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20384695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="24155896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="20384695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="337" mass="36489" checksum="82A80BD065DD7D31" modified="2005-04-26" version="1">MEKLSINNNNNNRRYQSRRFDGITIIRIVVLVFIVTVSTYFVNSYTCNQPHHNHSTRPSHYLPINGTHGLMNNDDSLHNKGAIGHYNTTVSLERRADENNSTTNGLFPSTSSSTFIFTPSSSSSSTFQQSRSSPQTTSTSSFVATTSSFQQETSQTSIPDTTTDFSFSSFSEAPTTSTTSSTSEFSSTPQETSNTVTSTSSTSTSSSSSPTSSPATTSASQHVTTFSSVDNGKTIVVTRTSVISSSPTASNSNNNKNNDNGGGLSHTNRIVVGVVVGVGGSILIGLLAVLFYLRKRNNRDYEGGWTFWRKNEKLGSDEFFNGELGVRDRNINQGSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AG74</accession>
    <name>Q5AG74_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C502800CA</name>
        <name evidence="2" type="ordered locus">orf19.11781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720612.1">
        <property type="nucleotide sequence ID" value="XM_715519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AG74"/>
    <dbReference type="GeneID" id="3637807"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502800CA"/>
    <dbReference type="CGD" id="CAL0000176130">
        <property type="gene designation" value="orf19.11781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02800C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100640_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AG74"/>
    <dbReference type="OMA" id="KHINHTE"/>
    <dbReference type="OrthoDB" id="4020944at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000176130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="240" mass="27853" checksum="9E1287684879BEE9" modified="2005-04-26" version="1">MSNQQGTQTQDTDYSSDFDEFAATFNNFKPKEFKSTTETSTLISSAARLELESITLKQTMSDTIKSFSKLPVKKLTETHSQVKQLYKDISDLKQTINETNQIVKEELLEIKNSFLNNQEQFNLQIQDLVSNQSMVLESRFSEQTNYVSEIIGKERQLFETSQQQCQYNLQEKINQQSIEYNKLTTQIEGQNKDIQEIKQFLKLLVPRIVGIEASYKVLSTENPIMESQQKPRPIKRKKQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-06-26" modified="2025-06-18" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AHJ5</accession>
    <accession>A0A1D8PH36</accession>
    <accession>Q5AHX1</accession>
    <name>TBF1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcription factor TBF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TBF1</name>
        <name type="ordered locus">CAALFM_C204200WA</name>
        <name type="ORF">CaO19.801</name>
        <name type="ORF">CaO19.8420</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Mol. Cell" volume="29" first="552" last="562">
            <title>Transcription factor substitution during the evolution of fungal ribosome regulation.</title>
            <authorList>
                <person name="Hogues H."/>
                <person name="Lavoie H."/>
                <person name="Sellam A."/>
                <person name="Mangos M."/>
                <person name="Roemer T."/>
                <person name="Purisima E."/>
                <person name="Nantel A."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="18342603"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2008.02.006"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="PLoS Biol." volume="8" first="E1000329" last="E1000329">
            <title>Evolutionary tinkering with conserved components of a transcriptional regulatory network.</title>
            <authorList>
                <person name="Lavoie H."/>
                <person name="Hogues H."/>
                <person name="Mallick J."/>
                <person name="Sellam A."/>
                <person name="Nantel A."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="20231876"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.1000329"/>
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        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
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    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="384" last="397">
            <title>G1/S transcription factor orthologues Swi4p and Swi6p are important but not essential for cell proliferation and influence hyphal development in the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Hussein B."/>
                <person name="Huang H."/>
                <person name="Glory A."/>
                <person name="Osmani A."/>
                <person name="Kaminskyj S."/>
                <person name="Nantel A."/>
                <person name="Bachewich C."/>
            </authorList>
            <dbReference type="PubMed" id="21257795"/>
            <dbReference type="DOI" id="10.1128/EC.00278-10"/>
        </citation>
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        <text evidence="5 6">Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters.</text>
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            <location evidence="3">Nucleus</location>
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    <comment type="induction">
        <text evidence="7">Expression is under the control of transcription factors SWI4 and SWI6.</text>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="602" mass="68134" checksum="B205AA9D538F4F27" modified="2005-04-26" version="1">MNSDNNPTREPGFKRRKIEPEIRNNNSPQQATSNPGSNDQVIEILSDEETAPPLQSTNTVVHLDTESEDSSLSDIDYRDDDNNGDANNDVQIVSVNTANPTPLSTPSSNLNHSGVPTNTNTNNNNNNNNRNGEDRDEDDDDLQILGVRNIYDPNNGRLSTPVGDIPFVREDNDYTIVEDAPRRNLNPAIARAIRRILDMERRYPLPSQEQIRQILMENRPWMQVSQSEFRDRRVTFDNSAGGGGEEGGGGGGESQPRPQNYHEALQESARRALAELAAMREAAERAERENSSRQGENSFGFGTPRRSYVELTENETSQPVAVPLPRQRSVHFTEEALRRGNGGPTFSESRDGNIIRRERRQPVRYTDSPQFLHNLPFSGAVVHRVPHELRFLGNTFHDVGFALDNLMDDSDTPRGFNSAIERSIMQRIEDDTNRMIDRRIAQETNYNKKTKNEIEKKIANQDERHTSNIKSNENLVCELCNIVLGEGAPDDFKGDIRYNEKFSKYCETYNCQAPWFCVYPFTEVDIELSKRIFVAKCGHLFCGRCVKNIGNRPKSRKSKTSNANSSTAEISILNPKFYAPSTCPELQCQKKFSSKSFTEVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANB6</accession>
    <name>Q5ANB6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C305140CA</name>
        <name evidence="13" type="ordered locus">orf19.13408</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723198.1">
        <property type="nucleotide sequence ID" value="XM_718105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANB6"/>
    <dbReference type="SMR" id="Q5ANB6"/>
    <dbReference type="FunCoup" id="Q5ANB6">
        <property type="interactions" value="869"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANB6"/>
    <dbReference type="GeneID" id="3635161"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305140CA"/>
    <dbReference type="CGD" id="CAL0000185296">
        <property type="gene designation" value="orf19.13408"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05140C_A"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="InParanoid" id="Q5ANB6"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000260">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="37"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="218"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000185296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="472" mass="54560" checksum="F887AD6CCDE5DE38" modified="2005-04-26" version="1">MVKSNSELLFFDLATQKNLYEKIYHAMDSSLANPIMKDYLIHLASTFPKFRIAELEALADLYNIDVDLSSHNEDSTFLVVSLENDEQARQLISRSVMSFGIYELWGYGETYDKLHEDVRAKSADKFEKYKDVSFKFDFKNFRGRPSNKGKVRIIESFSYLPFEGKIDLKNPDEIFTVVEEYKYNDRAKSESPIHIWFTRQLQLSERSNGLVETYDLKKRNYIGTTSFEAELSLVTCNLAQIAPGKITYDPFTGTGSFLVAAAHFGGYPIGSDIDVRMLNGRGNDKNVKSNFKQYGTSGNFIDVLTMDFTHNALRKDFQIDSIVCDPPYGVREGLRVLGAKNEEKAAGREHDVFDGEIAYLRREFIPPKKPYSLANLLEDLLQFASERLPVGGRLAFWMPTANDNFEETQIPQHERLELLHCLEQSFNQWSRRLLVYVKRDESYKGITSNGLKEKNIRDFRVRYFKRFIDKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANC3</accession>
    <name>Q5ANC3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C305090CA</name>
        <name evidence="1" type="ordered locus">orf19.13401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723191.1">
        <property type="nucleotide sequence ID" value="XM_718098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANC3"/>
    <dbReference type="STRING" id="237561.Q5ANC3"/>
    <dbReference type="GeneID" id="3635245"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305090CA"/>
    <dbReference type="CGD" id="CAL0000176433">
        <property type="gene designation" value="orf19.13401"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05090C_A"/>
    <dbReference type="eggNOG" id="ENOG502RPU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473257_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ANC3"/>
    <dbReference type="OMA" id="YLECDNS"/>
    <dbReference type="OrthoDB" id="4026135at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000176433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW28524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="576" mass="66226" checksum="775880AFC3623A76" modified="2005-04-26" version="1">MNEETLPVNESSLPRISSLTELPDEILNKIIDYLCTDQVTPRSNNSKSLIGFPKYTYILNHIRIGSLYHDILALSSTCTYFRKRLAPILFQSLSLVRTNQVDAVLESPKSQQLFSDTKTIQQHFMKELIVNNIEQCERAATTWTSFQTNTFDDKMFKSRYGKYLMMTRFVNYLECDNSFLNGEGIRLFSNLTALKVLDIGEGAVFMSNFELANLRYLAINAQTLIYSPQFLRIVPKLNRLDLFLDYGNLPSLVGIRPLIQQFRTFSQLTELVLLLNNPFTIAYLDTIKLLETISKNASNFAKLTIRYIRRNNESTVDQSGWELYQGRIGGKLLKVFKNLTDLIIDISILDLIKFDPETYSSPVLYTDHLMEKRITLVDEVVVGPNIDSTTREIAGVIIRHCQFTHLFFQYGESIEESHLHVLKLLTDFVGWLSNGHLDQSRNYLGIRQISLEKCWSMTDDSLLRDMIGSSIKSKSESDLSALQKVYPWTTTINNSPRYKDIDSYNINYVEEAGLSITDSRGYFIGVSDQDADRPQFTIVDKKSGIQTINMEFWSGESSLLDFEQYSIRQRRSLLWG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-04-01" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANE3</accession>
    <accession>A0A1D8PK31</accession>
    <name>NCE2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-classical export protein 102</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCE102</name>
        <name type="ordered locus">CAALFM_C304910CA</name>
        <name type="ORF">CaO19.13381</name>
        <name type="ORF">CaO19.5960</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Proteomics" volume="9" first="4770" last="4786">
            <title>Analysis of Candida albicans plasma membrane proteome.</title>
            <authorList>
                <person name="Cabezon V."/>
                <person name="Llama-Palacios A."/>
                <person name="Nombela C."/>
                <person name="Monteoliva L."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="19824013"/>
            <dbReference type="DOI" id="10.1002/pmic.200800988"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="MBio" volume="4" first="E00723" last="E00723">
            <title>The MARVEL domain protein Nce102 regulates actin organization and invasive growth of Candida albicans.</title>
            <authorList>
                <person name="Douglas L.M."/>
                <person name="Wang H.X."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="24281718"/>
            <dbReference type="DOI" id="10.1128/mBio.00723-13"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Involved in membrane organization. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. Non-classical export pathway also functions as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient (By similarity). Regulates actin organization and subsequent morphogenesis and pathogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Accumulates in membrane domains at eisosomes.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to decreased virulence and forms abnormal hyphae in mice. Shows defects in forming hyphae and invading low concentrations of agar but can invade well in higher agar concentrations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NCE102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723171.1">
        <property type="nucleotide sequence ID" value="XM_718078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANE3"/>
    <dbReference type="SMR" id="Q5ANE3"/>
    <dbReference type="FunCoup" id="Q5ANE3">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANE3"/>
    <dbReference type="EnsemblFungi" id="C3_04910C_A-T">
        <property type="protein sequence ID" value="C3_04910C_A-T-p1"/>
        <property type="gene ID" value="C3_04910C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635267"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304910CA"/>
    <dbReference type="CGD" id="CAL0000190917">
        <property type="gene designation" value="NCE102"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04910C_A"/>
    <dbReference type="eggNOG" id="ENOG502RZW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098356_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ANE3"/>
    <dbReference type="OMA" id="AFMWFLW"/>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="PHI-base" id="PHI:4003"/>
    <dbReference type="PRO" id="PR:Q5ANE3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090154">
        <property type="term" value="P:positive regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000431765" description="Non-classical export protein 102">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="7">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="3">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19824013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="24281718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="24281718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="170" mass="18123" checksum="CB8AC9D732D08858" modified="2005-04-26" version="1">MLAIGDVILRAFNFVFLVIALGLTGSLAATTITQHNPQINFAVFAAAFGLLTSSFYGVFAYFVAAFAWPVILFVFDFLNFVFTFAAATAIAAGIRAHSCSNQDYLDDNNIAQGSSGRCRKAQASTAFLYFSTFIFIASAIFSAISLSKGGLFGHSSRPAPRTGVPTMSQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANL6</accession>
    <accession>A0A1D8PJW3</accession>
    <name>SNU13_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SNU13</name>
        <name type="ordered locus">CAALFM_C304380CA</name>
        <name type="ORF">CaO19.13306</name>
        <name type="ORF">CaO19.5885</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723101.1">
        <property type="nucleotide sequence ID" value="XM_718008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANL6"/>
    <dbReference type="SMR" id="Q5ANL6"/>
    <dbReference type="FunCoup" id="Q5ANL6">
        <property type="interactions" value="1352"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANL6"/>
    <dbReference type="EnsemblFungi" id="C3_04380C_A-T">
        <property type="protein sequence ID" value="C3_04380C_A-T-p1"/>
        <property type="gene ID" value="C3_04380C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635173"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304380CA"/>
    <dbReference type="CGD" id="CAL0000183109">
        <property type="gene designation" value="SNU13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04380C_A"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="InParanoid" id="Q5ANL6"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="PRO" id="PR:Q5ANL6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000290657" description="13 kDa ribonucleoprotein-associated protein">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="126" mass="13601" checksum="15E80E88AFC2AB14" modified="2005-04-26" version="1">MSAPNPKAFPLADSALTQQILDVVQQSQNLRQLKKGANEATKTLNRGISEFIIMAADTEPIEILLHLPLLCEDKNVPYVFVPSKAALGRACGVSRPVIAASVTSNDASSIKNQIYGIKDKIETLLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2025-06-18" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q9Y872</accession>
    <accession>A0A1D8PFS8</accession>
    <accession>Q5AKV2</accession>
    <name>MET3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfate adenylate transferase</fullName>
            <shortName evidence="1">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MET3</name>
        <name type="ordered locus">CAALFM_C113870WA</name>
        <name type="ORF">CaO19.12492</name>
        <name type="ORF">CaO19.5025</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="34" first="792" last="798">
            <title>The MET3 promoter: a new tool for Candida albicans molecular genetics.</title>
            <authorList>
                <person name="Care R.S."/>
                <person name="Trevethick J."/>
                <person name="Binley K.M."/>
                <person name="Sudbery P.E."/>
            </authorList>
            <dbReference type="PubMed" id="10564518"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01641.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>124</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="AF164103">
        <property type="protein sequence ID" value="AAD45374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722228.1">
        <property type="nucleotide sequence ID" value="XM_717135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Y872"/>
    <dbReference type="SMR" id="Q9Y872"/>
    <dbReference type="BioGRID" id="1219192">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q9Y872">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9Y872"/>
    <dbReference type="EnsemblFungi" id="C1_13870W_A-T">
        <property type="protein sequence ID" value="C1_13870W_A-T-p1"/>
        <property type="gene ID" value="C1_13870W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636132"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113870WA"/>
    <dbReference type="CGD" id="CAL0000178072">
        <property type="gene designation" value="MET3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13870W_A"/>
    <dbReference type="eggNOG" id="KOG0636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_1_0_1"/>
    <dbReference type="InParanoid" id="Q9Y872"/>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="PRO" id="PR:Q9Y872"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004457">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000105952" description="Sulfate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="177"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for oligomerization; adenylyl-sulfate kinase-like" evidence="1">
        <location>
            <begin position="407"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD45374." evidence="2" ref="1">
        <original>E</original>
        <variation>K</variation>
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD45374." evidence="2" ref="1">
        <original>S</original>
        <variation>P</variation>
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD45374." evidence="2" ref="1">
        <original>H</original>
        <variation>D</variation>
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="527" mass="58859" checksum="05D9050CDE97F9BA" modified="2007-04-03" version="2">MPIPTPHGGKLRDLVIRDAPLKQQLLQEAKTLPALTLTARQLCDLELILNGGFSPLTGFLNQEDYNSVVNDLRLSSVKNESNGKGLLWPIPITLDVDETTSKKHSVGDRIVLIDLRDETPLAILTIESIYKPDKKLEAEKVFRGDSEHPANKYLLETAGDYYIGGELQGINYPKHYDYVDARKTPTELRQEFEKLGWAQENIVAFQTRNPMHRAHRELTIRAAQDIGDKAHILIHPVVGLTKPGDIDHHTRVKVYKQILTKFPDGLATLSLLPLAMRMGGDREALWHALIRTNYGVDHFIVGRDHAGPGKNSQGVDFYGPYDAQELLAKYDDELNIKIVPFRMVTYLPDEDRYAPIDTIDVKKVRTANISGTELRNKLKTGDEIPSWFSYPEVVKILRETNPPRSKQGFAILIDNSHKLGDYLSFALQSTLNQFSGERRITKLNAHQANDSFIVGELVKAGSGVIVPTTNPTPIVNVVGNGNSLVVNQKNNNNQASGNADGEFNLSNDDLVAVVDEIVNYLKDQGFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCM7</accession>
    <name>ZCF24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc cluster transcription factor ZCF24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZCF24</name>
        <name type="ordered locus">CAALFM_C102010CA</name>
        <name type="ordered locus">orf19.11999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="2226" last="2236">
            <title>Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.</title>
            <authorList>
                <person name="Liu T.T."/>
                <person name="Lee R.E."/>
                <person name="Barker K.S."/>
                <person name="Lee R.E."/>
                <person name="Wei L."/>
                <person name="Homayouni R."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="15917516"/>
            <dbReference type="DOI" id="10.1128/AAC.49.6.2226-2236.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2017" name="Genetics" volume="205" first="559" last="576">
            <title>Zinc Cluster Transcription Factors Alter Virulence in Candida albicans.</title>
            <authorList>
                <person name="Issi L."/>
                <person name="Farrer R.A."/>
                <person name="Pastor K."/>
                <person name="Landry B."/>
                <person name="Delorey T."/>
                <person name="Bell G.W."/>
                <person name="Thompson D.A."/>
                <person name="Cuomo C.A."/>
                <person name="Rao R.P."/>
            </authorList>
            <dbReference type="PubMed" id="27932543"/>
            <dbReference type="DOI" id="10.1534/genetics.116.195024"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probably acts as a transcritpion regulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 5 6">Expression is negatively reguled by the ZCFs master regulator of ZCF29 (PubMed:27932543). Expression is induced in the presence of caspofungin (PubMed:15917516). Expression is negatively reguled by the transcription factor HAP43 (PubMed:21592964).</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330616.1">
        <property type="nucleotide sequence ID" value="XM_019475071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCM7"/>
    <dbReference type="SMR" id="A0A1D8PCM7"/>
    <dbReference type="STRING" id="237561.A0A1D8PCM7"/>
    <dbReference type="EnsemblFungi" id="C1_02010C_A-T">
        <property type="protein sequence ID" value="C1_02010C_A-T-p1"/>
        <property type="gene ID" value="C1_02010C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645417"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102010CA"/>
    <dbReference type="CGD" id="CAL0000180650">
        <property type="gene designation" value="ZCF24"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02010C_A"/>
    <dbReference type="eggNOG" id="ENOG502S0WX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCM7"/>
    <dbReference type="OMA" id="RYHKEKC"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463352" description="Zinc cluster transcription factor ZCF24">
        <location>
            <begin position="1"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2 4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15917516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27932543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27932543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="701" mass="80767" checksum="CFE58387DC71FDD8" modified="2017-01-18" version="1">MPMRNRKIKPFEERKRVTVACNRCRSKKTKCDGGFPCLKCVKSNQECNISAPERPSNPTDFKEKYAQNRTYTCKLERIIQYLFPDIDLKYLRENTDTFEREVCINKSKLPRVGVPITSTKPPESEDNESKLNSLKNFNHTYVSPTDQSFIRFIDNSKNQRFMERNTLAASVFANSNIYAKHNLQVLVQNALEVFPDDNKIRKLVGIFLNICETNYFYVHHGRFYKQVDQLLLKRQENDIEYLVNNWTTVSIVSVMLALASGFEFIADNSPMPKVTPDTTPGLMCYYAALPFAGFLIDLKSVESIQCLLIFGVFMTTNKLENFQSIDGGYTFMNLALEIAIANKLHLKEPFENYPEEDREVFKRLWWTCYTMERRHGVNIGRVETIAPEDITVELPVDMRGLYSNLGLSNHLSQISIIQMNYIFRDIMDLFCSKSKSHKDQSISIDPKIIRKFVEDLEECKLNFPNYTKIDNLDPSSTRYRACIHLNLTYYLAKIYIGKPFLLYKVENYKRLNENNGYESAFVDHLSSICIDAAFCSVELLSELQKYNKLGLFSCTDINVCNIALFAILVFLKIDRSETTLLFLRKGLSILKIMSDGSASAKSALQRLRKLDKLVCDLTELDDMEKDLNPHNVLGHESASKAFPMDTSNQDAVLEFGNLPYVDSSANLGGYMNTQQYFFDDMDNILMSVDDDIFNLQKWSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PD19</accession>
    <name>A0A1D8PD19_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C103580WA</name>
        <name evidence="2" type="ordered locus">orf19.3059.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="353"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000200179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120562" checksum="6D79B4E147BFDEFB" modified="2017-01-18" version="1">MTVLPNEYHSALTQLLENLLSTDNTIRAEAEKSLDQNWTSKDNVELLLVFLAEQACQGNNDTIRAFASVMFRRMAIKSPKELQSVTDRTIGVIGEPARQQIRGILLAGFTSPQSNQVRHKLSDAISEVAKEDASPAGTWNELIPALFEATRNEDPSFRESAFRVFSASPELIDNSYIDEVLPVYNAGFEDANDDVRIAACTAFVAFFRKLPKNTWKLLSPLLPNLLNSLPRFLQNGQDHALASVLEALIDLVELAPKMFKDMFPTIIEFCSAVAKNKDLDLNSRMAALELLSTFAEVSPSMCKLTPTYTEQMVLITLSMLTEVCIDDDDAAEWNNKDDSEDEDEEQEYGAARQALDRVALKLNGQALAGPLFQYLPAMVSSSNWRERQAALMALSSAAEGCADVLMNEIPKILDMILPSLEDEHPRVQYAGCNALGQMSTDFADVIQRTSGDRILPALISKLTNKSVPRVQAHAAAALVNFSEAATKEVLEPYLDDLLNNLLILLQSPKRYVQEQVLTTIAIIADAAEKTFVKYYDTLMPLLVNVLRTDVGAENKLLKAKCIECSTLIALAVGKEKFAPHSQELIQLFGHIQQSATEDDDLVKSYLEQAWGRICKILGKDFLPYLPSVLPPLMLTAKASQDISLLEEEDAEELKLNEEWDVINISGKWIGVHTVTLDEKVTAMDLLRTYAVQLKEDFMPWVKEIAEEIAIPGLDFYLHDGVRGSAALTLASLLRCCVAATGNNSTEALTLWSKICNKLSESLCSEPVPELLIAYYTTLVESINVLAPNAVSGTQLQALSKAVNANMIEIYNRIKERDNAEDEYTEDVEEDEEEYTDEELLDEINKVIAVVFKNVKSNFLETLQILGPTISSFINDENTTVKFCGLSIVSDILEHCGPDSVPFKEMFVKVISESVTSANASIRQICTNAIGMAAQYGGDGYAEFCLSLLEPMFKMAMVPDARADENVYATENCVSAIAKVCHRFSSSVPNLDSLIDQWISLLPIVQDESAAPFAYMFLSELIDRNHPSVLKQVPKVVESVIQALAHASISGNTAQKVVISTRTLLGSIPHEEAVALLQKNPSDLDVVQKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEE6</accession>
    <name>A0A1D8PEE6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C108770WA</name>
        <name evidence="3" type="ordered locus">orf19.12197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723422.2">
        <property type="nucleotide sequence ID" value="XM_718329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEE6"/>
    <dbReference type="SMR" id="A0A1D8PEE6"/>
    <dbReference type="FunCoup" id="A0A1D8PEE6">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEE6"/>
    <dbReference type="GeneID" id="3634788"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108770WA"/>
    <dbReference type="CGD" id="CAL0000179983">
        <property type="gene designation" value="orf19.12197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08770W_A"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEE6"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000556">
        <property type="entry name" value="Proline utilization protein PrnX-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1780.10:FF:000014">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000179983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38323" checksum="C40045C56C0EE30D" modified="2017-01-18" version="1">MKVISDQAVTEFLNKTLSKESILDAFQPTLLKSLTTYSQDSDHIVPPRTVQPSNNPNSDTTHIYMPCISPDEVGLKVISGGPGNNSKGLGFQGCVLIMDEITGQLKAVLNANNLTAFRTALASSLGLTKLIAPSNANILPELSAFGVGLQAYWHIKLALLLYEGKIKEVNILNRTLKNAEKLADRLSKEFKNVKFNSFSYQDESSGFIPHVQNSSIIFGCTPATSPIIKKEYLNTNPEVPKFISLIGSYKPHMIELDLDLCKELKQKGISIIVDSKEHTLHEAGELIQAEFDETQLIEIHELCADFDATVTDKSTGITVQKIVGLSIMDLSIGKMISNEIGNNAVVVDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEU2</accession>
    <name>A0A1D8PEU2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C110320WA</name>
        <name evidence="4" type="ordered locus">orf19.12368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723585.2">
        <property type="nucleotide sequence ID" value="XM_718492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEU2"/>
    <dbReference type="SMR" id="A0A1D8PEU2"/>
    <dbReference type="FunCoup" id="A0A1D8PEU2">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEU2"/>
    <dbReference type="GeneID" id="3634907"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110320WA"/>
    <dbReference type="CGD" id="CAL0000183720">
        <property type="gene designation" value="orf19.12368"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10320W_A"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEU2"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="BRENDA" id="3.5.1.89">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="354" mass="41280" checksum="76292B7B7A132566" modified="2017-01-18" version="1">MIFKLPLILLRLYITSFIIWIFQTTILPQTLTKLTNVSIKTQTFQHYYPYTSLVNTPKNSNSINTITNSNITYIIAHPDDEVMFFAPSIIELKKPKYNNQINLICFSKGNYIKSMDEIRQSELIQSSRILGIDQVSILDYQDGMNETWQLNDIVQSLHENLSPTNSGSDTNSNNKPSVLITFDDQGVSNHPNHISLFHGTKKYIQELRRKSENKNKTRIKTTTTTTINYIDIDSSSSTKFYVLKSLNFFEKYSFTILGNIEILFNYISLLIKKFINININVSFFSNQIIKSKFDNNNNNLQLQNLNDIRFYSDLNMLSLSYAAMAYGHFSQMVWFRYAWLLLSRYLTYNHLIEQ</sequence>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A1D8PF82</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713013.2">
        <property type="nucleotide sequence ID" value="XM_707920.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PF82"/>
    <dbReference type="STRING" id="237561.A0A1D8PF82"/>
    <dbReference type="GeneID" id="3645318"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111730WA"/>
    <dbReference type="CGD" id="CAL0000201060">
        <property type="gene designation" value="orf19.8737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11730W_A"/>
    <dbReference type="eggNOG" id="KOG1550">
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    </dbReference>
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        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
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        <property type="entry name" value="Sel1-like"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
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        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="415"/>
        </location>
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        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
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            <begin position="553"/>
            <end position="562"/>
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        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000201060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127830" checksum="31BC30EBE22A1B27" modified="2017-01-18" version="1">MHEQIEKLESKPSYEPVDQHNDSLDQQSSYVNQSFNHSQSQAVDQQQQQQHLYMQGMNSQRMSPRFSSNNNLFANENQTSEEFNVSQPNQFFNPYQMYQANSFYQPGPALTASYANDEDNADEQESNSSSNYETSSSEDLEEGEGDNDNGEDDEDEDEDDSVSSGSTAPVTQHPYYEQWRRYYEALAMQQQQIMNRQSMYGPNFQGFNPMMYFANPQMMQMQMQMPYFFNPMMMQGNNGSNPQLNPDSAAMFQQQMQQMQQMQQFSQSMQNLYNQPQSQPPQQYNNEQQPQSRSPYTPSNSNHASKRNSYINVNESQEKNSTKEPPKNDFLSSYKKSRNLNTETIDEDENELILQSRKSTVKSNRYPSAPIDTPTQERFSSSDRHSRVTSLQINFKPTGYGNYQDDEEEEEEEEFTGSSSRVLSKVRQGSLGGNIDSLAQLNLQDSNGALGRHISDYTKYLFDDDEEEEEDDSGSEEGNNRTVHLSAYGDNDRTLISAKGREADGYRHDTNPQLPTPNTDDGLSRQGTSASEASIQSGGSLKFTVADSKRRSNLPLKPVTNNKPKKKTKNAKKSKNTLEIQPPVCQEYNPNMPLPELSMGMMPFASSMAGLAPPPPPVFDGSPSVEPMMMNYSNPMLSQTTEYSGASTPSKRRQSVSTFDTRPRSMMVDTPTPKANKRSSVPVYTSQQKQQQKQSQSQSQQKIAPVAKTTTSTPVKVQDSTISKKIDEFVRLRSRIAAGNKTPEYRLHWVKMLIVATNYKLYSYINIKGEPIYQEQAVSNKAQFIKSSVTHILKLIKELSSGTYEADGVKCEAYFIYANLLKQDYLVSYNQDFNMEKNIDKAIDYYDRVLEINSKDFKALYKLGEIYEYEFDNEFNKAVEYYTAAAKFGYNRAILKMAMLYLQEPQMRSIKYMKYLKDLSNIDLNEVRLDEEDSSEMEEVIGLACYELGKIFEGIYPGDLTQDNEFIQKSLDMAPVNYAKSLTYYNKSAKLNCLLAQVRLGIVYERGELNRQRNPSKSIQWYIKASSSPLSFKRHPDAMVGLARWCLTGSEGASKHIPVPVPDRAVMWCKRAIDEFSSPDAMSFMGELCEMGLAKGRPQYWYEKAYKMGNREAGRKLGYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFF6</accession>
    <name>A0A1D8PFF6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Membrane protein TMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C112580WA</name>
        <name evidence="8" type="ordered locus">orf19.11242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705696.2"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="CGD" id="CAL0000201411">
        <property type="gene designation" value="orf19.11242"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12580W_A"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="TDE1/TMS"/>
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        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="43"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
    </feature>
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            <end position="183"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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            <begin position="443"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000201411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52344" checksum="9A2C7FDD86C1E4FB" modified="2017-01-18" version="1">MGAAISLPLMPITSLASCCGAAACSAFCTSIGGTFKSSIMTRITYAILLLINSLLSWIALSPFIINKIEKATFGFINISCGPDGSQCISFTSVHRINFALGILHLILASLLVNVKSTANPRAIIQNGCWKLKIFAWITFIFINFVIIPDSFFIFYGNHIAIIFSTIFLGIGLILLVDFAHAWAEKCLEKIEMEELTGEGDASFWKKLLIGGTLAMYIGSIILTILMYWFFTGSGCSMNKTAISLNLVFSIIISAMSIHNTVQEYNPNAGLAQSSMVVFYCTYLVMSAVASEPDDKFCNPLIRSRGTRTASVILGAFFTFIAVAYTTTRAAANSAFSSESSPNFVTTGITTTSQQPSARNEMRYQAIKQAVDEGSLPESALNQLDLYEDEDVNDEEIQSVQYNYSLFHIIFFLATQYVATLLTINVKQDDYGDFVPVGRTYFASWVKIISSWVCFVLYGWSLLAPVIWPDRFGIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGT0</accession>
    <name>A0A1D8PGT0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C203130WA</name>
        <name evidence="1" type="ordered locus">orf19.13205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715324.2">
        <property type="nucleotide sequence ID" value="XM_710231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGT0"/>
    <dbReference type="SMR" id="A0A1D8PGT0"/>
    <dbReference type="FunCoup" id="A0A1D8PGT0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGT0"/>
    <dbReference type="GeneID" id="3642993"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203130WA"/>
    <dbReference type="CGD" id="CAL0000176044">
        <property type="gene designation" value="orf19.13205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03130W_A"/>
    <dbReference type="eggNOG" id="ENOG502RXXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGT0"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000176044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW27350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="206" mass="23577" checksum="5000FF55745DF4AC" modified="2017-01-18" version="1">MKYIIEHMEEGFSEWVILEYTQIIKDIGKDNLILTSLPPSTTEKDIPKRLLELGLQWTTKECVDIDGGIDKSKVCLLDPAAETDLTPQDKSKFDYFVFGGILGSHPRIDRTGLLREKYGFSGRRLGSLQMTTDTAIRTTQRIIENGVAFEDIKFLDYPEIKYNKYESTEMPFRYVTDNEGNPILPEGMLELIKNDAEQSIDDLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHY8</accession>
    <name>A0A1D8PHY8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C207270WA</name>
        <name evidence="7" type="ordered locus">orf19.9824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714873.2">
        <property type="nucleotide sequence ID" value="XM_709780.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHY8"/>
    <dbReference type="SMR" id="A0A1D8PHY8"/>
    <dbReference type="GeneID" id="3643474"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207270WA"/>
    <dbReference type="CGD" id="CAL0000181049">
        <property type="gene designation" value="orf19.9824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07270W_A"/>
    <dbReference type="eggNOG" id="ENOG502QT1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHY8"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="137"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000181049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="339" mass="38197" checksum="B88746D38D40164D" modified="2017-01-18" version="1">MNRISSISGLTPNRFSQQVRSNKLREFPHFFISRQFITSSINHKSKMTNSQKPNEEPKRFGLENQVKRNPHPDFNKVENSRPPFDFENTWTYTQIPNKDWKVGSGANDPSWKDHKKLEIDPYGEGRNPVDNYKTLISAIVPRPIGFVSTVSKTGERNLAPFSYFTMVNHDPPIFTLGFSGGKGTPKDTCNNILETGELTINIISEWFVEAANYCSTNAPPGIDEWKLSGLTPLESAKVKPQHVAESAFSVEAKLVMSHEWKSKTDPNRATGVLCIVEGVNFHVREDVINSDLNNLDIGRLKPVSRLGGITYGRTVDGYERLRPDFGKESATNEVKQLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI01</accession>
    <name>A0A1D8PI01_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">YCS4</name>
        <name evidence="15" type="ordered locus">CAALFM_C207470WA</name>
        <name evidence="14" type="ordered locus">orf19.9439</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713140.2">
        <property type="nucleotide sequence ID" value="XM_708047.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI01"/>
    <dbReference type="SMR" id="A0A1D8PI01"/>
    <dbReference type="FunCoup" id="A0A1D8PI01">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI01"/>
    <dbReference type="GeneID" id="3645196"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207470WA"/>
    <dbReference type="CGD" id="CAL0000201859">
        <property type="gene designation" value="YCS4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07470W_A"/>
    <dbReference type="eggNOG" id="KOG0414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI01"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903342">
        <property type="term" value="P:negative regulation of meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070058">
        <property type="term" value="P:tRNA gene clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000687">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="66"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="456"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="867"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000201859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW27745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131895" checksum="DD2EB1E191A2AFF6" modified="2017-01-18" version="1">MDFSLSSYFNAFDVDKDYQIEFSDVDSKLESITDSLANNPESLNFNQELLEDLIELTHGFRELEEKKRHQLAYLVTSSLNAVGQSYGNMLQSGDFHDNVDTIKSTLERYGYLMFVLLKYLGKEDFSQVGNARSQKSVPREVLARWKSNCTEVENGLTAVITVLSLDLSKVFVTTPERDSFVELFSRPIINLMESPERMKLVPIKLLIFRALCIAVTKHKHGSMLQHSIIQCLTYYAHLPQYMAGLLHTLTEKYDYMVLTEEILREISQTHFNSNDTNGPKAVSEFLIKLSELSPRLILRQMTSISQLLDNSNQTLRCSVVEACGNIVVDILKNSTRDQGEDEDADYYRHQVAKLLNLLEERFLDQNPYVRTKAFQALSKVADLKVKLTERRQKMMMLAVRSLEDRSTLVRRNAIKLMSKLILNHQFQGSHGTQLALTFWKQKLKDAEAELMKYIPADVQAGPEQQSDTSDVEDDGDESDKVEQENNLNGQAEATKKDEPTMDIDKEDVSEEGDREGESDIVANTSSFNDNLPDATVLARVKLTANYYKDAVDFVEAVQHGTDVISGLLFSKNRNEAIDAMDFLVLADAYGVENSHVGIRKMLHLVWMKGSSDEGKSVPAHLIDCYKSLFLIAPNSASKIEKATYIAKNLIGLTLKASVADLASLEKLLGLMYAAMMINFEVINVLWQIYNLSDRSEEVRRQKRGAIIILGMLSLEDNQIAIKGFDSLLNIGLGDEGKDDLILGRYTCIALQRVIPADAKKNSTMVKIPREEEAITKFKQILIDYNENPEWYSISEEAIDAIFQLSSEPDRVCSDVIKTKAVAVFGDNRASVENPDVALSQLLFIVGHVAIKTIVFLEKLEGQFKKKKHEAESKKGTANSNNSSTAADAQEEAEGENELEMIGGTSEDDFADAVVHVKERELLYGDYSLLGRFGPLVKEICAHPKQFSNLRLQRSAVLCLTKLMCVSSIYCEENLPLLLQIMEKSDDPVTRCNCVLGLGDVAVCFNNIVDENTEYIYSRLTDENIMVQRTCLMTVTFLILAGQVKVKGQLSSMAKCLENPDQSISDMCRLFFAELATKDNAIYNGFIDIFSGLSNDETLAKDEMKRIIRFLVGFIDKEKHQKQLAEKLLARLPKCQSENQWQDVAFVLQTIPYKNDAITAALEEGFTLVSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI35</accession>
    <name>A0A1D8PI35_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">YCK22</name>
        <name evidence="14" type="ordered locus">CAALFM_C208270CA</name>
        <name evidence="13" type="ordered locus">orf19.9766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716062.2">
        <property type="nucleotide sequence ID" value="XM_710969.2"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI35"/>
    <dbReference type="GeneID" id="3642347"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208270CA"/>
    <dbReference type="CGD" id="CAL0000183445">
        <property type="gene designation" value="YCK22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08270C_A"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI35"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000183445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW27818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="378" mass="43076" checksum="C3C947FF47E64C1D" modified="2017-01-18" version="1">MNFGTSHSSSSKNSHNNNVVGLHYKIGKKIGEGSFGVIFEGVNILNNAQVAIKFEPRKCEAPQLRDEYRAYKQLQGSKGIPNAYYFGQEGVHNILVIDLLGPSLEDLFDWCGRRFSIKTVIQVAIQMIRLVEQVHQQNLIYRDIKPDNFLIGKPDTPEANQIFFVDFGMAKQYRDPRTKQHIPYREKKALSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGALPWQGLKAPTNKQKYEKIGMKKQTTSINELCYGFPIQFAQYLTYVRNLKFDETPDYQYLVGLMEKASISAGIELDGHFDWMDLNGGKGWDAALNKKANLHGYGNPYPHPSQGQRRXAATTAGTIQTTTIITKISTIQFTPSTITWEFSFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIF7</accession>
    <name>A0A1D8PIF7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">inositol phosphorylceramide mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.370</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">MIT1</name>
        <name evidence="12" type="ordered locus">CAALFM_C209150WA</name>
        <name evidence="11" type="ordered locus">orf19.11558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <reaction evidence="7">
            <text>a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1&lt;-&gt;6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)</text>
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        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000190541"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="464" mass="51938" checksum="3C39C3ECB1E1B8F5" modified="2017-01-18" version="1">MPLFSDHAYTSITIKINQLADPKRNDEIDDSIELYLSDLIELIKVQSNSGAVEAARAIRKKIKYGDSRAEQLRALQILELLVLNGGPSIGPIIARDDKLLDVLKGIINGTARTGVGVEYDCKVQKRVVAMAIGWKTELDGLDGYKYMQSLYKAIPRRKRVSSSHSGHRDRDVYDSDENSEDVLDPYADDAQLDSHASNRNVSSPRTPRSPPPPRPSTKSPYASGKKNDDKDKKKNKKKKKKKRGLVYADEEFEIPQINYKVEAPKIRELIANCYTHTTALNNLLLQLPADESPLDNDKTLEEFAKCKKIRRKVLSYLQYVGAGSPEAKSSEVAALDEEFLGSLIGANEQLVESFKRFDFRAGYSKDNPAPNYDDESDSDESYYTSEESEEEPDDVEEQDENSISARLQNATLQSKSPPPPRPSKPSNLQSSFQPRPKLDKVETSESIEGNPFGDRNAVTKSVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIL5</accession>
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        <submittedName>
            <fullName evidence="13">Amino acid starvation-responsive transcription factor</fullName>
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        <name evidence="12 13" type="primary">GCN4</name>
        <name evidence="13" type="ordered locus">CAALFM_C209940WA</name>
        <name evidence="12" type="ordered locus">orf19.8938</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the bZIP family. GCN4 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709439.2"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0837">
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cross-pathway control protein A"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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            <end position="187"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="323" mass="35451" checksum="174A4BEE59E0DBCE" modified="2017-01-18" version="1">MPATTPIIYEDSLFESQDLFASPFKQQHQKVDTVATKNEIGLELNLGLPEMQKASETVSTPFQIHSSVLESVFSTNLDGVNDIDHTPMFDELDLIMDGAKVNSSEDWVALFGDDNDDGVAIAGATSKEPMLSLNEDNENNDDDADDDDDDDDALVPREDTIEALLLEPSPNRTISAATSASTSSLNSPESTIATTVTAGGEVVVASKKQFQLVTPNPSSTLPTPLLDSKNSKKRVKVDHLGCVTYSKKHRSQPLQPIVVDDIKDAAALKRAKNTEAARRSRARKMERMSQLEDKVENLINEKQALQDQVERLQELLRVNGIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIY8</accession>
    <name>A0A1D8PIY8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FLO9p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FLO9</name>
        <name evidence="9" type="ordered locus">CAALFM_C300580WA</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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            <begin position="20"/>
            <end position="1244"/>
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            <begin position="14"/>
            <end position="342"/>
        </location>
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        </location>
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    <sequence length="1244" mass="130935" checksum="7EEF03C9AD648573" modified="2017-01-18" version="1">MLFKNFLLLFIATATTVFASYDVSSSLIHYHDFNFNVGDIAIRNGASFSLVNTFDCLFKGDLTIEEKSKLYITSTGRALILHIAGLFNKVKNDGLLVVNTLESHAAAICKILGASFVNTGDAIFAFQGRFLPPIIALTARQWQNFGRMHFLQKFPSKSLAMLGHFGGTIENHGTLCFTNQIFKQLTTIDGRGCIALEKSSSFFIENSLFPIDRRQVIYMGEGNPSIQAVVTTFPQTFKVANFGGNGAHKIGLNLPLMYFPHHDEHDWFYDEETGILTLRATEFLSQNFDIGLGYDPSKFEVCSDESVGFLWVFNGAIKYNGPAPNPGRPSICQACPGIHSAPGAEPSTTTKSIITTKTDGAVCTEVDTVIVSSDKSGSWYTTTSGASINCGTTSEAPIPNPRVTITTTWTEITTATVTETGTKTDTVIVQVPTTPNPQITVTKTWTESFITASTVTGDKTDTVIVDIPETTTSCLTTTNTWTGDYITTITTSGWIIVEVPTQNVVTIVYTDSQSTSGKTTTTPVVTAETSATTGNDNTASTTDATGKTLTTVTSSNDNTTSTGDDSTTASTGNDNTDSTTTTATVNKNIDSTTNATDNTSKATTTGNDNTDSKTTASGTDSTTTTGDNNSESTTASTGNDDNDSTTVTTGDDYTTVTTDNDNTASTIVTTGNSNTTTLTDATGKDSTTTTDNGHDESTTVTTGDDDTATTKDNNTASTTTKTGDNDTATTVNHSIESTTVTTGDDNTATTGNDDTASTTDATGNDSTTATTGNHSIESTPVTTGDDNTATTGNDDTASTVSTGNDNSASKTGATDTENDTTSTGDDDTATTIPTDAPTTGDFVSSTETKYTKSKKTKTHKTKTFETELTKTSTSLEASASSSEYPFESTSDQICQCTPVTVTEYIPQSPIPKEVESTTQSTKSFASESSSLEPTVSVSLSKSESTTDITAETSHESTTEQKSETLDQSTSVVTPATNQESTTDTSSDNNVESTSVVTPATNQESTTDTSSDNNVESTTAGTPATNQESTTDTSSDNNVESTSVVTPATNQESTTDTSSEKDVESSSQFATPSNPVHTSLSTEYYTTGVTSYYTSYVTVTAETTEVLTLTSCVDNHCHKTTATTGVTVVTLTTSDIQTVITTYAPLTQTVTLGIAGSKIVDLGCPIGNFGYKGYVGKGIKADDKGIDANAHAGFKIGFDAIKRDQKVANTTNVTVQSSKNAGAINSVYSSIELLCAVAAIMVLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJB8</accession>
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        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
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        <name evidence="7" type="ordered locus">CAALFM_C301910CA</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28230.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6230" checksum="7CB293C565735BAA" modified="2017-01-18" version="1">MNSEKIIEVIIAIFLPPVAVFMKCGATTPLWINLVLCIFIWFPAILHALYVVLKD</sequence>
</entry>
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    <name>A0A1D8PJN4_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719968.2">
        <property type="nucleotide sequence ID" value="XM_714875.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJN4"/>
    <dbReference type="GeneID" id="3638416"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302790WA"/>
    <dbReference type="CGD" id="CAL0000198258">
        <property type="gene designation" value="orf19.7902"/>
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        <source>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="172" mass="19536" checksum="617C8953D974205A" modified="2017-01-18" version="1">MTCQTGRKCSLGIEEPIDISSKNVPLNAFLIYTMSSTLPDHNSTNSWNEYHNNLSITNNTQVTTSCADNVKTTSNVPRCATDINSKMTTSEFETLHRCRFSVCDLNNLENYLYQSEREECSRVIEQLETHNGKSISTCCNSNTDINAQCNQMKNHKRRKSIALKFKKPQTLL</sequence>
</entry>
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            <fullName evidence="2">glutathione transferase</fullName>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
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                <person name="Thorstenson Y.R."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:90779"/>
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        </reaction>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
        <alternativeName>
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    <gene>
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        <name type="ordered locus">orf19.5927</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS15 has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
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    <dbReference type="GeneID" id="3635194"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="40S ribosomal protein S15"/>
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    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
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        <property type="entry name" value="Ribosomal_uS19_CS"/>
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        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
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        <property type="entry name" value="Ribosomal_uS19_SF"/>
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        <property type="entry name" value="PRK04038.1"/>
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        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00203">
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        <property type="entry name" value="RIBOSOMAL_S19"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456553" description="Small ribosomal subunit protein uS19">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q01855"/>
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    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
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    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28484.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="142" mass="15939" checksum="6DD146891D092A94" modified="2017-01-18" version="1">MVDATAPKKRTFKQFSFKGVDLKDLVEMPTEEFTKLCGARVRRRFSRGLDSKPMGLIKKLRAARAATEPNERPAVVKTHLRNMIVVPEMIGSVVGVYNGKVFNTVEIKPEMVGHYLGEFSITYTPVRHGRAGNASSKFMPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK87</accession>
    <name>A0A1D8PK87_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">OST1</name>
        <name evidence="12" type="ordered locus">CAALFM_C305530WA</name>
        <name evidence="11" type="ordered locus">orf19.6988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709601.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C305530WA"/>
    <dbReference type="CGD" id="CAL0000177262">
        <property type="gene designation" value="OST1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05530W_A"/>
    <dbReference type="eggNOG" id="KOG2291">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="RYEYARE"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
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        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009026865" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000177262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="470" mass="54210" checksum="2F8EE63CD2AC8D8C" modified="2017-01-18" version="1">MWKFFITLGVIFSICSAQLLDTVSFDSNWENLHYIRNVDLNKGFVKETDLIEIKNINSKPQDEYYFTINDGFDSVNELSVFSAFLNDNLLEVKVDEIVANKVFKLKLPVPIAPNSNVELKINYVYIDTLVPIPTKISMDAVQQLLFKTNKFPYSPYLTKEYTLSLTGMSKGQEMQLHIDVNATEGTPDLKPRVDNQTLKYGPIAEDIQAFTLSPMGLLYDHNRPVTKAVNLNRSIWLPASDVNKVSIEEYYELTHVGAALDSGFSRIDWMKGRYEGTRNHWALSHLELPLLDRDLDGYYYTDKVGVVSSHKVVKNHLLLSPRYPLFGGWNYNFTFGWSEDLSRFLHKLHDTSDEYIIKFPILNSLRDVTYGDVYLEFYLPENAEFQNVSSPIPFESITIDNELSYLDVSKGHTKVTVHYKNLFDDLHKLDVFVKYKYTKINFVYKIVRISGFVFIGLISYYLLGLLDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKG7</accession>
    <name>A0A1D8PKG7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 6</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">E2 ubiquitin-conjugating enzyme 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein UBC6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin-protein ligase UBC6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">CAALFM_C305680WA</name>
        <name evidence="17" type="ordered locus">orf19.7347</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716588.1">
        <property type="nucleotide sequence ID" value="XM_711495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKG7"/>
    <dbReference type="SMR" id="A0A1D8PKG7"/>
    <dbReference type="FunCoup" id="A0A1D8PKG7">
        <property type="interactions" value="1006"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKG7"/>
    <dbReference type="GeneID" id="3641724"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305680WA"/>
    <dbReference type="CGD" id="CAL0000184069">
        <property type="gene designation" value="orf19.7347"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05680W_A"/>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKG7"/>
    <dbReference type="OMA" id="GWSVATI"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000184069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="243" mass="28254" checksum="6FB5357E5962101C" modified="2017-01-18" version="1">MASRQATKRLNKEYKSIQANPPPYIIAHPSEDNILEWHYVLTGPQDTPYEGGQYHGLLRFPPQYPFQPPSILMITPSGRFKPNTRICLSMSDYHPDTWNPAWSVSTILTGMLSFFTGEESTTGSINTSVNHRKVLAQKSKKFNVDNDRFCREFPDLVKQYHEEIAAEKVKLEQQEKEQQLNGQQQGDQKEQLANLEDLDPEDRIRVMQQLEQEQKQKQKQKQNQDDENLNQDNDNSNRMCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKH4</accession>
    <name>A0A1D8PKH4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">FG-nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C306440WA</name>
        <name evidence="14" type="ordered locus">orf19.7433</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716094.1">
        <property type="nucleotide sequence ID" value="XM_711001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKH4"/>
    <dbReference type="SMR" id="A0A1D8PKH4"/>
    <dbReference type="FunCoup" id="A0A1D8PKH4">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKH4"/>
    <dbReference type="GeneID" id="3642281"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306440WA"/>
    <dbReference type="CGD" id="CAL0000196266">
        <property type="gene designation" value="orf19.7433"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06440W_A"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKH4"/>
    <dbReference type="OMA" id="GDILWPG"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
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    </dbReference>
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        <property type="term" value="F:RNA binding"/>
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    </dbReference>
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        <property type="term" value="F:structural constituent of nuclear pore"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
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    </dbReference>
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        <property type="term" value="P:protein import into nucleus"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:telomere tethering at nuclear periphery"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="13">
        <location>
            <begin position="953"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="506"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="745"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="909"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
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        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000196266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1096" mass="110367" checksum="0008608ED34E9A58" modified="2017-01-18" version="1">MRRAKCKEREKSREEKKNHNIRILHFNTNQLSLHSQSQLNIEMFGGGASSGFGGFGSSTTTNNSPFGGGAGAGAATTNTGASPFGSTNTNTTGGGIFGSNANSSTGFGSSNAFGASSNTNTTPAFGGNTGGGLFGSTANGTGSSPFGQQQQQQQQPQQTTSAFGSSNNSGSVFGSSATGGGLFGSKPATSTFGGFGSTTANASSPFGASTTNAFGGGASVDPNVNNGTAAKQFTPFTEKDSANMTNVFQNICCMPEYKNFSFEELRLKDYEQGRRFPPAGATANAGFGGAAGTNATGGGFGFSGAATGASPFGSGTAGAANPSGSAFGSAFGSTFGNKPAGTSPFGAASTTGAFGGTNQNQSPFGSNTAGTFGSGASNTFGGGANSTFGKPATGFGSSGGAFGGNTNTGGAGGGLFGSSGNAFGGQSSSGFGAANNSSPFGQAQSNNAFGGANNNSPFGQSNTQQQSGGLFGSGTGNAFGSNTGGSTFGSNNTGFGAGGNAFGQQGNTGFGANKPVTTGFGSSTSGGLFGQQSQQQQPGATGGLFGQNQQQQQNAGGGLFGAKPAGGSVFGQSNTNASGGGLFGGQQNTPTTGGGLFGSKPAASGGLFGGQQSGQAQQGGGLFGQQNQQNTSGGGLFGNKPTGPTTTNGGGLFGNKPATGGGLFGGQQQQTQQQQQPQPSQLGGGLFGAKPGTTASSGGGLFGGQQQTSNVGGGLFGGGAASTGGLFGAKTNANATSNSTSTGGLFGGATTVQQQPQQAQQALASINSQNPYGNNPLFQSITGTSSQQQQQQQQQQQTNNLPQFSLVKSAAPIKKAVTLGSTSQKVTPLFKVSSLPTKTSTELVKEDTVKNKKTDDLFSAATDQAIISSDIFRPKESFKSLVLDKSKASNALLTESSSGPTKQVTFVLDKSESKELSASTPEPLDKDEKSKLELQGEQQKQQQGQDQDSDVDSEGYWMSPSLQELKKKSLLELKSIPKFKIGRKHYGELEFLEPVDLTSIVNLDDIAGNLVTFSNKTCVVYPDDNKPKPGEGLNLPARITLEGCYPINKADKLPILDPKSEIVKRHIENLKTIPEMKFISYDPTNGHWTFEVQEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKV4</accession>
    <name>A0A1D8PKV4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">FUM12</name>
        <name evidence="8" type="ordered locus">CAALFM_C307640CA</name>
        <name evidence="7" type="ordered locus">orf19.14016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719823.2">
        <property type="nucleotide sequence ID" value="XM_714730.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKV4"/>
    <dbReference type="SMR" id="A0A1D8PKV4"/>
    <dbReference type="FunCoup" id="A0A1D8PKV4">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKV4"/>
    <dbReference type="GeneID" id="3638489"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307640CA"/>
    <dbReference type="CGD" id="CAL0000174516">
        <property type="gene designation" value="FUM12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07640C_A"/>
    <dbReference type="eggNOG" id="KOG1317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKV4"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="433"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000174516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="510" mass="55274" checksum="1A0F22078C088D7C" modified="2017-01-18" version="1">MLRLSRNFKAVAPLRTFITSTINFQNTRIESDAFGEIEVPTDKYYGAQTARSKSNFKIGGEAARMPVPVVRAFGILKKSAAKVNEELGALDPKLSAAIQQAATEVAEGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGELGSKKPVHPNDHCNMSQSSNDTFPTVMHIAAVTEINNSLIPELTKLRDSLQAKAEEFKDIIKIGRTHLQDATPLTLGQEFSGYVQQLTNGIERVEKSLPNLLYLAQGGTAVGTGLNTKKGWDSKVAEEVSRLTGFPFKTAPNKFEALAAHDAIVEASGALNTVAASLFKIANDIRYLGSGPRCGYGELSLPSNEPGSSIMPGKVNPTQNEALTMVATQVFGNNAAITFAGASGQFELNVFKPVMIANLLSSIRLIADGAASFRVHCVDGIEANTDKIDKLLHESLMLVTALNPKIGYDAASKVAKNAHKKGITLKESCLELGALSSEEFDQWVRPRKHDWTKRLSFVDSIAIYLYTCIYSLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL08</accession>
    <name>A0A1D8PL08_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C400290CA</name>
        <name evidence="14" type="ordered locus">orf19.13100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330899.1">
        <property type="nucleotide sequence ID" value="XM_019475354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL08"/>
    <dbReference type="SMR" id="A0A1D8PL08"/>
    <dbReference type="STRING" id="237561.A0A1D8PL08"/>
    <dbReference type="GeneID" id="3644994"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400290CA"/>
    <dbReference type="CGD" id="CAL0000193776">
        <property type="gene designation" value="orf19.13100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00290C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL08"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000193776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="434" mass="49971" checksum="54351B1E41EE07C9" modified="2017-01-18" version="1">MAPPTLTQAAPAAPQLDTPKMLVGEHTLPASWWTSESIFELEKRAIFHKSWMFCTHSSRFAKAGDYYAFNLAGINFFVIKSKIDGQLKAFHNVCRHRAYPIVRKDQGSSTVLGCKYHGWSYNSDGILRRAPHFDNVEGFVKEENSLFPINTHVTTQGLVFVNFSSDPIPFDDWFSGLTPEMNEFDFSDYEYHMSYELDGKFNWKTLMDGYQECLHCPTTHPGLNTAFKMETYKVVPKNRYCRHFAKIVRQEKPVEKQDSSSWFGFKKETKEVKETKPNPGGEFDGLWVYLFPSNGINCYSPAWYSIRVLPITAKRTILQYDIYTKKGLDDEEKKEFVDFLQQVELEDFDLCELTQRNLNERIYSTGYLHPEKERGVLYYQGVVRDMVKEHFALEQAAGQSIDPAAVGTNPKNGEVEELEGICKSLECGKETVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL37</accession>
    <name>A0A1D8PL37_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">HIS5</name>
        <name evidence="14" type="ordered locus">CAALFM_C400650WA</name>
        <name evidence="13" type="ordered locus">orf19.11653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712631.2">
        <property type="nucleotide sequence ID" value="XM_707538.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL37"/>
    <dbReference type="SMR" id="A0A1D8PL37"/>
    <dbReference type="FunCoup" id="A0A1D8PL37">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL37"/>
    <dbReference type="GeneID" id="3645756"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400650WA"/>
    <dbReference type="CGD" id="CAL0000198056">
        <property type="gene designation" value="HIS5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00650W_A"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL37"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000198056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="389" mass="43173" checksum="6BFC016D99FC3BF3" modified="2017-01-18" version="1">MFDISAIIRPNILTLEPYRCARDDFKTGILLDANENTHGPALPSPDANEAALELNRYPDPHQHELKQQIIQFREQHPNKYATEKLSIENLCLGVGSDESIDMLLRCVCVPGKDKMLICPPTYGMYSICATVNDVAIEKVPLTIPDFQIDIDGILTKVKSDPTIKLLYLTSPGNPTGKLIDVEDIIKLLKESLKAWQGLIVVDEAYIDFTKPGSSMSTLVNQYPNLVVLQTLSKSFGLAGIRLGITFSSKQLSWYLNAMKYPYNISSLTSNVAIKATNEGLGVMENYVSKIVEQRELVLEKLLSLKYVGRNIGGLDSNFILIEILDKDGKPSNDVAKKLYNTLATDNSVVVRYRGSELNCVGGLRISIGTAEENKQLLTKFESVLNEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLA0</accession>
    <name>A0A1D8PLA0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Opt6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">OPT6</name>
        <name evidence="12" type="ordered locus">CAALFM_C401320CA</name>
        <name evidence="11" type="ordered locus">orf19.12125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722726.2">
        <property type="nucleotide sequence ID" value="XM_717633.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLA0"/>
    <dbReference type="FunCoup" id="A0A1D8PLA0">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLA0"/>
    <dbReference type="GeneID" id="3635603"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401320CA"/>
    <dbReference type="CGD" id="CAL0000182066">
        <property type="gene designation" value="OPT6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01320C_A"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLA0"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="3634"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000176106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="3826" mass="430978" checksum="28560D7FAEDCD51D" modified="2017-01-18" version="1">MSSKEKPSKEDIRGQLSDIQKRLFSKKPSSGDTSGATTSASTNSNHRPVLKESNHHPQGKSSLLSGGVGSHEQERFADFLPPLPKGSGNASASLGPPAPTSNSLKRVPPSHSSRLGPESKGNDMNFVVGLSENLLTECRRLNAENSKYREKLKSALDEVQNYKDEVFKLKDFNKSHNTNEQALKDKNWELESKVIKLDDELSVLKKSHEKTIHENSELANQISNLNKINDKLEISNQSLTKSLHDTKQSYQSEISALNARIENLNDENDQLHLRLAGEDTTNSSRVETSKEATLPSMDETTESDDDTTEFDSILKELQPCDMPESNPSNPQLEIDTLRSTLQHSNRTIAKLRSSMLKLRKFDQQQTNSSNLQRTPMKFGSKPKLRASKSELTPSHRTSMLLSPAKKNSKFSILDDDTTHNNDEPEPFPTDGGKWEDFITDELETTPSKSVSKKLIADSDAESTHSRAMNVTAATGDYSIPYLVESSDSETEPQSLDEDSPSKSIKSSLSSKELQESSKLRNKQIQQYASSNNLVMVPFEELEKLKSIDDEKLLLTAQERGYHLLTAKEYEELIDEEEMKKRLESKGLVTIPFDELESIKTCLDKPDKAYITDKANSMGLIVTSNDLYDTLVKNANEPSVDHLTAKAKAQNLTLLSNEELEQLKNPSLDQLTKLASKHESRVVSNNEYESLIDPSVETITQKAKSHKMTIVSDAEYQKLIHPSLDVLSTHALDKKHTLVKNSELEELKKSANSPSLSQVKVHADKLNLVTMSKPDFTDLFKTANEPSISHIRSKASDLGYTVVKQQEYDDMTNSINHPDVADLKGKLPDYKILPLSEYDEIYKLAHEPEVDHIKTKATSLNHYLVSNEDYDKLQNPTLETLQSQADTLNHSVLDKTKLADLEKLAYNPDLDHLQKVLKEIDYEALPKQELEALNNPTTDSLSEKASKLNCEIISQEDYKELFSLAHDPSLEHIHANATKLDQTVLSNDEVNELKALAYTFSIERLQSLAKEKHHTLVESSELDALKNPDITQVKEKAKDFGLETISHDDLNELKNPTRERIEGIVHDWNCTVIDNTDLDNLKNPELETIKVKAEQFGYHLLSKEDRETLEKLAQQPDLDHIKQKSKDLGYIPVKEEEHQKLHNLAHNPSIDHIIEKSKHYGYIPIKETELKSLKEVAESPDLEHITSKAKVHGYVPVKQTDFETLKTLAHKPDLDHIIEKSKSLGYTPVKDSDYDVLKKLVHEPSVEHITKKSKELGYVAVKETDFNDLNELAHNPSVDRISDKAKEHDLVAVKVSDYDHLTRLANEPPIDHITEKSKELGYVVVEQSNFTNMQKLINEPTKEEIDSKATKLGLVTMPKTKFEELEATVNKPSSEFLSEKAQLYDSIVISKKQFENPSLEFIKEKSATHEHEVIPSKDLANLKNSLESPSDEYLHDKSKVKGLKLVSNDEYNSLVNLAHKPEKSHLVEKASALGMSLIGIDALNKLKKDLEHPQKDYLEEKAKALDLSIIENDKLSIIQTLAENPDSAHIEKVAKQKDLIVLPLSEHEKLIKDSTSPDIDHIKLVAEKQMLTVLTNSAFKDLTERVENPTLDQIKEAAEKNNQVVVPTQEYDALMHPDEVAIKTHADRLSLNVMPIKEHAKLMEDLEKPTLEYLVNKAAKYDSIVVTKDANTKLEKLAYSPDVEHMAEIADAKDLVVVNKEEFANITKLANEPHEDHIISKAKNLGLVTINESDHRELLQPSKSKLEQHASRIDHLLVPENEVHRLRDIESTPSREFIETKAAQHDLATLTRKEHSELTSNANEPSKDHIIAKASAIGLVAISKKKHEQTLKALEEPTLDYLSEKAVKNYKSVIIPTDKYESLKENLESPDWNYMTEKAKSHDSVIVKQNDYNDLVKVSTDPSVQFIEEKARKYNKSVIDSDELKNIKRVAFNPTKEELSERAAQDGLLVIDQNEYKSLEEKIENPTSDYLKEQASKFNFTMVGTDDYNKLTTLIASPSKEHIEEKAQSAGLVVVPKDEYEKLLEKSNNPDKSRLSKLANAKGMLLIDKEEHAKLTDSLKNPSIEFLKNKASEHGNVIIPDEEYKKLLSDIESPDFEYLEKKCHDRNMSILPTTDLKQLKTVFAGPSIDFLKEHSAKANYELIPRSEYEILKNSIDNPGSEFIQTKASKYGLVAVTEEEYDSLTDPTKESLIENASKLGLSVIEKSELELLRSKLDNPSVEYMKLNSEKLGYILVSSNEINDLKTAIDQPTEKYLEEKANKLGLHVMSIKEYQSLNEKATKPSKDHIASVAGLLGLAVIGDKEHKDLLSKSKSPSLDHIKEKAEKHDHVVIPQNEHSKLVERANISIGDLAKEQGMVVLPSDSHAELVKNASKRLEDHAKENNKIIISPDEHKQLVTKASKTLSDLAKENKSVVVPIEEYQDLNAMASKSLQDHATEQGVIVLSKNEHDDLTRAANKTAADHAKEKGMVLLKAEDHDSLVKQASKSLQDLCKEQGMVLVSPEEHKELTTKASRTLHDFATEQGVIPVPIKEHQELTTKASRSLKDFAQTEGMVVLPQSEHAELTEKARKSIEDLASEKNFMLLEKTHYEDLLDKANKSLEKLAQEKGMSVVSPEELRELKENAEKPLDVRAKEQGKTVVGIEEFNELNNKIEKPSLEYLKECCKKHLKKIVSEEDYEQLQSRANQTVDEKAKSMGLVVIKPEELDQLKKSVESPSLDYIRLKAADQGFEVIEKDEFSLINERYKKSVKDLAEENGLVALKVEDYNNLIQNANEPALAHISEMATKHEHVVVSANDFNKYLNTFEHPELEFIKEKAKEQGYTVVLLDDYASIVAENKETLEEKAEKAHAKLIPVEEYTTQQETLNNPSIDFLNEKAKLLQKVIVPQSEYDELVKSASQSVHDKAAVASMVVINKDEHSKLQATLLAPSLEFLHSKCNEKGMTLVEQKDLDNLKSSVEDPSLEYLEKSASNKGYALVDKKILSEMKENLDQPIEEKAQAKGLVVLPVDEFSSLKKTVEDPSIDFLKEKCGNSGYHIIEKESHENLVKQAASTLEDKALEKNMVLLTPEQHKQLSEPSLESLKDFASKQNYDLISHTELVELTTKANNPSIEKLKEVAKVNQFVLIPTDEHIEMKKQAEATIQDKLEGTDWKLIKNDEYDELLVKAHQPTIDDIARNAAAIGFGVMSVEAINKMKEQANESIYERGSREGMVVMSKEQHDEMREKIQTPLAERAKSEGYALIKPDELQKLRVAESRTVEDKALAEGKVAISEKLYNEILEEKNMWKEKYAAVDLSTGEEHTLSTVKEKLEELGFSVIPKENSKSLPAEKSFSSDSEDFHFHDADESFILSEHELSYSASRLGLVLLSKEEYNNLNKVDEEKVKGLAKGLSLTVIPESEVINWKQSLAAKDEEIHKLNLEKEEQVKKVALLENEESNTAETPERTDAVKKDILTDKDVVVNAATKLALLPVPESQYVGTTAHPRPDVNNVKVVPTSYFNQLLKLKAMSIEKCSDDVFKQYAEKRGYVHRDQLTPVLASTTQFKGTPVQDRDSLDSMSRITPPINPAVKQRQVTPVSKRSLSLSSGGRVSFTRGLPESNSVVSRLSEQSVHQSLRSQGMFSMATDVSFTDRSMIPAITQVVIGEYLFKYYRRLGAFKVITETRHERYFWVHPYSLTLYWTENNPILSNSSSSKTRAAAIVSVESVEDNNPLPTGLYYKSIIVHSTDRSIKITCATRHRHNIWYNALRYLVNRNIDDLVIDEDTNIDELSDEFEVNTSAGLAPAAVKSESHRNLESLMDTGDRRAYPRPKRITSSPSSPASGRLSRFSSMRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN90</accession>
    <name>A0A1D8PN90_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hsp90 cochaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">STI1</name>
        <name evidence="10" type="ordered locus">CAALFM_C501820WA</name>
        <name evidence="9" type="ordered locus">orf19.10702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714608.2">
        <property type="nucleotide sequence ID" value="XM_709515.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN90"/>
    <dbReference type="SMR" id="A0A1D8PN90"/>
    <dbReference type="FunCoup" id="A0A1D8PN90">
        <property type="interactions" value="1052"/>
    </dbReference>
    <dbReference type="IntAct" id="A0A1D8PN90">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="MINT" id="A0A1D8PN90"/>
    <dbReference type="STRING" id="237561.A0A1D8PN90"/>
    <dbReference type="GeneID" id="3643758"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501820WA"/>
    <dbReference type="CGD" id="CAL0000199753">
        <property type="gene designation" value="STI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01820W_A"/>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN90"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000199753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="589" mass="65950" checksum="3F7DA56CCBAABA1F" modified="2017-01-18" version="1">MTTADEYKAEGNKYFAAKDFEKAIEAFTKAIEASPEPNHVLYSNRSGSYASLKDFNNALKDAQECVKINPSWAKGYNRIAGAEFGLGNFDQAKSNYEKCLELDPNNAMAKEGLKSVESALASGGGDDKDLGFGKILNDPNLYTKLKNNPKTSEFMNDPQFVAKLERLKTNPQLGNPDMFSDPRLLTAFAALMGIDMDLPNMGFTAPNESQSNASEPKSEPKSVPESKPEPKAEQKEEESTSAKDEDTPMTDAQDDTNDNDAKTQADNAKAEGNALYKKRQFDEAIAAYNKAWELHKDITYLNNRAAAEYEKGDYDAAIATCEKAIDEGRDMRADYKLIAKSFARLGNIYLKKDELPEAVKNFEKSLTEHRTPDVLNKLRSTQREIKTRELNAYIDPEKAEEARLQGKEYFTKGDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLLSFPDAIQDCNKAIEKDPNFIRAYIRKANAQLAMKEYSHVMDTLTEARTKDVELGGKSIHEIDELMNKATYQRFQAIEGETPEQTMERVSKDPEIVQILQDPVMQGILAQARENPAALQDHMKNPEVYKKINMLIAAGVIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        <name evidence="5" type="ordered locus">CAALFM_C501980CA</name>
        <name evidence="4" type="ordered locus">orf19.10683</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:C5_01980C_A"/>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
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    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
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        <property type="entry name" value="Nucleobindin"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0106">Calcium</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111183" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000197371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26349" checksum="C21272191B658851" modified="2017-01-18" version="1">MKLSLVSPLLLTLLSFTTAHGGHGHEQESLKIKPQDLSWQDWHMKEEHGLEEYDGKTFFILHDLNNNGILESKEILNLYGLVHKIIIGDGSGMGQDKIEVTPELQKQVVENIFQLIPHGNPEGISQAEWLKFYENGGRLPDLGYGPGHHLGFEEEYEEHHWRKYHANDDPDVKIKHKEDIEHELLHHQQEIEETHDRSSRLKKFAGDYWSEINIDNLKPKYRKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PNU9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C503950WA</name>
        <name evidence="5" type="ordered locus">orf19.10728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710956.2">
        <property type="nucleotide sequence ID" value="XM_705864.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNU9"/>
    <dbReference type="STRING" id="237561.A0A1D8PNU9"/>
    <dbReference type="GeneID" id="3647445"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503950WA"/>
    <dbReference type="CGD" id="CAL0000195679">
        <property type="gene designation" value="orf19.10728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03950W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PNU9"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="551"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="774"/>
            <end position="802"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="127"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNW6</accession>
    <name>A0A1D8PNW6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial fusion and transport protein UGO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C504170WA</name>
        <name evidence="6" type="ordered locus">orf19.11381</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
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    </evidence>
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    <sequence length="535" mass="61486" checksum="318722268D7F96F3" modified="2017-01-18" version="1">MSSSHPDTQVLRPYYDHDTFNAGYSVIFKKGVGIIDPKTNRPVTSNISEKLINQSIDENQGIIRNSFKHGGPVGINATSDKNYVYDLEFNEYFESNNLIEVFKNLLGNFVRSYIKVLLTQPLEIVRLVLQVGKFNFSETASKTSKKLDLSKSKRLLSETEDDTEATTEQDEHEYTRPQRSSIYDSDRDVDNEDEDEEPINYFQSQNEQQVWSGHEVGGFNKTATPTKQGKKSYRDDKKRLRNNKIKPKSLHTADILTAIINKDGPFAVFRGINASFIYQTLSHTIEAWITGFASPFLGIPDPFFLDLTHSNDPFKSLWLSVTACVLTGIVLMPLDLIRVKFMITQFNSKPLNENDALEEVTEEIVQSTRSVRESIRNFPVYYLLHPSTPIVFLTTLHQLSTSIFRKMAPYILFIKFNIDSYSSPNIYTFVNLLSLILEFFIKLPVENLLRKQQVQFLLTPKREDTKKVITIEDPKKSLIVEFNDSSKDIQDSTFWERLKQLGLFNGWRIGVLNVIGFWGYNIIKSDGSELKEERL</sequence>
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<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
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                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
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        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS15 family.</text>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="151" mass="16946" checksum="7C17E28730C1FC50" modified="2017-01-18" version="1">MGRMHSSGKGISSSALPYSRNAPSWFKLSSDDVVEQIIKYARKGLTPSQIGVILRDAHGVSQAKVVTGNKILRILKSNGLAPEIPEDLYYLIKKAVSVRKHLEKNRKDKDSKFRLILIESRIHRLARYYRTVAVLPPNWKYESATASALVA</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
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    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714329.1">
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    <dbReference type="KEGG" id="cal:CAALFM_C601160WA"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000189329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="210" mass="23148" checksum="5D3FF3501997DF92" modified="2017-01-18" version="1">MPRKPTNTLIITNIDDSLLSNPEPIISLLGDQPYMIELIVLMKFKRILLYCQTSKIATKTKTFLLNQWETTTIGGGGGGGGGGGSGGGNSISISYSLKDNSRILDPEEEDEEDGKDGGGKGGRFLDIPKDLEIKRFLISPPASPHSEWDDWDKVEEGPNETNIHDYLWEKLKTHENEEKEKDSGISEDDDGCESIKKVELPKIVLNATDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RQD6">
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="25"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="14"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000193285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="178" mass="20224" checksum="FFC120121DB4E3EB" modified="2017-01-18" version="1">MKRSLNDSNSSDSSTPPPTKSSKRLKLENEIFSTSIQDIEKMFSEEITTTTTTTTTTTTTTDTSVSPELLLFPPNKQLAPPVRITRNTTSYNSPDSCQYLDNIIPSTSFNYDCINMSFLEPSPSGNFIPTIRPNNTITNMYLDIDHDDYDDYDYEYDYKPLINQDLLMIDQLILKSSI</sequence>
</entry>
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    <name>A0A1D8PQ72_CANAL</name>
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            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C603540WA</name>
        <name evidence="5" type="ordered locus">orf19.13143</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718058.2">
        <property type="nucleotide sequence ID" value="XM_712965.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ72"/>
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    <dbReference type="STRING" id="237561.A0A1D8PQ72"/>
    <dbReference type="GeneID" id="3640244"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603540WA"/>
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    </dbReference>
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        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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        <property type="entry name" value="MFS"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="60"/>
            <end position="85"/>
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        <location>
            <begin position="57"/>
            <end position="457"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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            <dbReference type="CGD" id="CAL0000190473"/>
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        <source>
            <dbReference type="EMBL" id="AOW30283.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    <sequence length="465" mass="50510" checksum="DD14F0F0FDCF312D" modified="2017-01-18" version="1">MTNTISSFESVELTAVSLRHQIQFRPEDESSSDSLTPIATVTEDDSSIEYPEGGLKAYSVILGSFLGLIVNLGLINSIGAIQAYVSTHQLSNLKATSISWIFSIYLSLAYAGGIITGPIFDKRGPLEILIAATAFIFLGLMGAAQSVEIWQFILSFISLGIGSGLGTTPLIVVISHWFCKKSGSFTGFATSGGSIGGLIFPLMLRHTYNVYGYVWAIRILAFMSLGCMVCSIFLVKERFHKVKTEVIAQQTQKTKFSIQVLMNKLKSVNASDFKYIYVILGAFFAELSLILLVTYFPSYAIAQGASESTSLLLLTVWNATGILGRWIPGFVSDIYGRYNVYVFMLILYCLCIFVLLYPFGSSEKILYAFAGVGGYCSGSILGLLPACLSQITPVNEIGTKYGILNAVLSLANLFGIPIAASIIKDGTPKEYNNFVVLVGCLAVAGTLFWYFSRVAISGFKLNIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQM2</accession>
    <name>A0A1D8PQM2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">CAALFM_C700430WA</name>
        <name evidence="17" type="ordered locus">orf19.7077</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
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        <property type="protein sequence ID" value="AOW30422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715275.1"/>
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    <dbReference type="SMR" id="A0A1D8PQM2"/>
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        <property type="interactions" value="25"/>
    </dbReference>
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    <dbReference type="GeneID" id="3637993"/>
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        <property type="gene designation" value="orf19.7077"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00430W_A"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="WMMGIAY"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferric reductase transmembrane component, putative"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
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            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="310"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000183819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW30422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="586" mass="66490" checksum="0067586DB4F5B6C9" modified="2017-01-18" version="1">MMKRGVSYNGLDCLADASSDAYMKYKHQSQAEIPWVSQTKYAKYTVYFGIATIFVAFVKQIYYKYRDYTYRSKQSSNFGTSLIDIWISYCRYYGYKQLPTWLTYFSIPGSVGSASYMFLSSLYMLCYCLVPHFWYRGCAGFGSSPLAVRAGLMATALTPFIYVLAGKSNAITLLTGISYEKLNTFHQYTGVACFILSVIHVVPFIYQDLAEGGSSNLKMNFKDSFEYYSGIPPLILLGLLCILSKSYIRKVVYELFLHAHWMMGIAYFGTLIWHINKELGADDYMWGALAFWATQIIYRILMKTAFKPNAMFLRSRQAQLEKLGSDGVYQVVIGNTTGVNWKPGQHCYLRFAGVRILDSHPFSIASVDEEDKTAMKFIIKAQKGLTRKIYQELDKSITSNKNVYVDGPYGGTFRDPRSFKRVVLLATGTGVTATLPFLTYLAKTDSIVKRVSFIWIVRSQEDIHWVKSELQECQKLGGSKIDIHIHVAAKKSIYTKGDFEKEIESEETNLNEEDWLIDYGKPSVTSILKSMAGSLAARNMIVCSGSDSLKREVSSIVSELQSLVFNNDLVRSNVEEIYLHTESFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQR2</accession>
    <name>A0A1D8PQR2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial 37S ribosomal protein MRPS16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C701020CA</name>
        <name evidence="4" type="ordered locus">orf19.7012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720306.1">
        <property type="nucleotide sequence ID" value="XM_715213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQR2"/>
    <dbReference type="SMR" id="A0A1D8PQR2"/>
    <dbReference type="FunCoup" id="A0A1D8PQR2">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQR2"/>
    <dbReference type="GeneID" id="3638020"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701020CA"/>
    <dbReference type="CGD" id="CAL0000194758">
        <property type="gene designation" value="orf19.7012"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01020C_A"/>
    <dbReference type="eggNOG" id="KOG3419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQR2"/>
    <dbReference type="OMA" id="RSKYWLG"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1320.10:FF:000013">
        <property type="entry name" value="Mitochondrial ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000194758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="173" mass="20151" checksum="0AD5E6D8ABCEB6A6" modified="2017-01-18" version="1">MDLLNFFFRFHHLLFYQINTIIALFTHHNQMSSPIMSVAEKTAYKRNMVKIRLARFGRKHQPIYNIVVMKAKKAQQKLPMEVIGTYNPIPVPLSGNDSGLKIKDVSLDLHRTKYWLGMGAVPTPRVTWLLKKVGLLPQFWPKTSALSQHIDKPVVEEIRETQELPVDYVRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQR6</accession>
    <name>A0A1D8PQR6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C701040CA</name>
        <name evidence="4" type="ordered locus">orf19.7010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720304.1">
        <property type="nucleotide sequence ID" value="XM_715211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQR6"/>
    <dbReference type="SMR" id="A0A1D8PQR6"/>
    <dbReference type="FunCoup" id="A0A1D8PQR6">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQR6"/>
    <dbReference type="GeneID" id="3638018"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701040CA"/>
    <dbReference type="CGD" id="CAL0000189748">
        <property type="gene designation" value="orf19.7010"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01040C_A"/>
    <dbReference type="eggNOG" id="KOG0511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQR6"/>
    <dbReference type="OMA" id="EGARCIY"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000261">
        <property type="entry name" value="Assembly of substrate-specific ubiquitin ligase complexes modulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000262">
        <property type="entry name" value="Assembly of substrate-specific ubiquitin ligase complexes modulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000352">
        <property type="entry name" value="YIL001W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000189748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="610" mass="69511" checksum="F49ED2CE1C8D3CFA" modified="2017-01-18" version="1">MSSDPARPDLDVSIDSIFSISHQLDRGTPASSTSSSNQDPEVAKAFSEICLACRTGDIEVVDSLLSTPNLDINQVDEYDYSPLILSSLCGHYDIVELLLQRGAVCDRDTFQGARCIYGALTDEIRDLLVSFDISKAVDVTQPFAGHIASLLNPLLGTITADVVFQFKQPGIPEDLRVFKSHRFLLASRSPYFEEKFNGEWENLTVITMPMSVDPAVFKRIINYFYLRTHAVLNDSYAIQDQLLKLARMYELDDLVDGIEEIKGIEDEKARAKIGHDLSFKFVEKARKDLDDFLLQKILGEKLSTDMDLKDDVDLEDIDCTEFLSDAQREALLEADSIPDVILACVDSESESVIYYPVNKSIIARSEYFDTMFKSEMFTVAEEDLPLYREAGVQVINRPQLDTDHLAIIQVSTSTANQKIAEMVLSFLYHDNINNIPLDLSLELLFAADELFLERLKTMSAVNITSQFQKFNFQEFQSLQDKLDCNAYDLIRASWQTRCDKLEQHVTKMIAYNLSEIFNSEIERQKLSDLIKESAERIKERQDTDTIELVDDVRYYLTKKYAINEEIGSFDPTFSSDKNTDDINLYKTALLQYEKDVEIIDYLLDQLHLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRB9</accession>
    <name>A0A1D8PRB9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arf family guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C703480WA</name>
        <name evidence="3" type="ordered locus">orf19.13997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712157.2">
        <property type="nucleotide sequence ID" value="XM_707064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRB9"/>
    <dbReference type="SMR" id="A0A1D8PRB9"/>
    <dbReference type="FunCoup" id="A0A1D8PRB9">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRB9"/>
    <dbReference type="GeneID" id="3646230"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703480WA"/>
    <dbReference type="CGD" id="CAL0000187267">
        <property type="gene designation" value="orf19.13997"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03480W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PRB9"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000020">
        <property type="entry name" value="Guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="49"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000187267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118385" checksum="65298007A003D159" modified="2017-01-18" version="1">MVSAVSNITESSVVNSTTPESSINMTKPPPISTSNKIKHHPPKDDKPLPITPNRDEHKTEDKGTSTSSKGEPSSVTNTNSQKTESANKEAKNGSESPSEDDTEYRLIAKRLFDEEFVSIKPQEYTQFLAAGDRDSTKIRNYYMNLFTWPPNLLKSTRMLCSKLYLKGESQEIDRILSSFTKSYLKQHPKNVFCTKNFEQIYIIIYSLILLNTALHNSELNKKSRISQSDFIRNTFTTFVQQNEKLSKSLSVKQKIAIENELSNFYEDLSKNELHLKTADEAGSSSISQSQHHHSHHNHHHHHHHHNDHGHHNNTLGNRLSKASQDSAATETTNASTNSPITPANESNNEDGAVLTRQQSASSIWSTDTTNRRSSLAMKRYTTTTSEISNFNATAQNPNRSPVQRVGMARALVGHQRQQQFQSEKSSMYKNGNPSLYSQASAVPQLKNRPSYDQMKSLNKRSSRQSVISKDSSHNDDDMISVLSFDTMNLPMHDESDSQRFNQQMEDFNVDDYQDKYDLTLELQGSPYLKEGLLKLKILNNDSVDEIDGNSNPSASSTPANHGKFLSFFSRPANSSSSTSNMNNHKFTENFVVISKGELSLYSFDPKVIKKFKKRNGHQQQQTEPDDDDIVGDGNWLKNAAKIGTYNLCSTYADLEKTTSQGKVLWSLTFPKTSKRQPKKFIFEAGTKEVALEFINTCNFWAAKITAIPTLEESVSSLEYGWTNLDYIIAHRESFKKSRNIMKYEPVVKGVYLSNYIVNSEETNHLGMMRQFVKTSNYYNQLKKLYNEFTEMRQKFLINLPKCHFNCSNHSKILSNYDTKINDYNLEMKKYKNYLIILGFGLQLRFDLEEQDRQQQYDTSLENEDVDDDDEGEEDYETIGETLATTDRASSAGAKSNDTSYQDDELTKLVKFEIKKLFFNMKDISKVIPTFRSSKSIKNLADLAQDIDNKLVKSPKTFTLANYNDNESPINQLLATTNANPTVKSSSMIMESSIAEEPEDAEDSETTRRSSKVNNSKDHSPATSISSSIKKPNLKIANSEVSALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRP1</accession>
    <name>A0A1D8PRP1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cullin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_CR00370WA</name>
        <name evidence="8" type="ordered locus">orf19.7497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718654.1">
        <property type="nucleotide sequence ID" value="XM_713561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRP1"/>
    <dbReference type="SMR" id="A0A1D8PRP1"/>
    <dbReference type="FunCoup" id="A0A1D8PRP1">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRP1"/>
    <dbReference type="GeneID" id="3639684"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00370WA"/>
    <dbReference type="CGD" id="CAL0000197877">
        <property type="gene designation" value="orf19.7497"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00370W_A"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRP1"/>
    <dbReference type="OMA" id="MFKDMTI"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="859" mass="98986" checksum="1321C0597BE53C51" modified="2017-01-18" version="1">MMPPGGRKSKIRPPRKSLISSSSSSENSTTDPVIDFDKNWSVLSSAISQIQNKNVSNLSYEQLYRKAYVLVLRKFGGKLYDNVANVIKTHLLTRREKLLSVSANHDLFMQSILQEWSEHLQAMKFISDVLMYLNKVYVAEHKKLLIYDLGIQLFKDYVIKYNNDEVGSKIVNMVIDEIAKSRTGVVITSSMYITKIINMMELLVEPSGSSDILFGDSYYQIKFEPKFLKSSEESLYNLSQEFVSHNLGTKYLQLTTQFIKDEDNRVRFYLPPSTYPKLVELMNNIMIKDKIDKMILSSNQGLEYWLKPVVSNIFEDTNIETYHYADLKMLYNLIGRFDDEYQLLRLRLKEAIVAQGNSLPDYVRSSIENSGKKQSNNSPAFATKWIETILKYRDQLMQVWKNSFDENLMIEQTFTFAMRDFINGSNKRGPASVNAPELLSVYMDYFIKQLTKGSSSNKDISLKSGDQTEDLISNSIQFLRFIKDKDAFEANYANHFAKRFLNSKTGNSPSSNKDIEEIILAKLSEEMGTSSLDKVIKMNRDVRSSKDTTNDWKRYLNKQSKSTDLVEMELKICNVTDWPKSMTKDYKWFSRTENEETPFKWPRQLRNTIKQFDEFWSNGKKNDNKSLYWSPKFGSMDLRITYPSRTYEINLSTFAAIIMLLFAPQSTNADGSTVSAFDEMKELTYEEILELTGIPEPELKRHLQSIAVAPKSRLLVKVPMSKDVNKNDVFKLNAKFKSPSVKVKVLTVSASSSSSASSSSSSSKNTNKSVAKTEQEEELEEVNANIMEGRKIEVNAAIVRILKSRQSIKHNDLIEELLKQLSNRFQPSIILIKQRIEDLIDKEYLKRDTDDRNLYHYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS37</accession>
    <name>A0A1D8PS37_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hnm3p</fullName>
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        <name evidence="9" type="synonym">HNM3</name>
        <name evidence="9" type="ordered locus">CAALFM_CR01900CA</name>
        <name evidence="8" type="ordered locus">orf19.10118</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
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    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713160.2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:organic cation transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:biotin biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF16">
        <property type="entry name" value="7-KETO 8-AMINOPELARGONIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000199767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="498" mass="54583" checksum="7C5C97B5535EAC1B" modified="2017-01-18" version="1">MDTKYENKAESLEHSVDSKESQAEPSLEKNFGWWSLFAVSFSLTCSWVGVSASFGTSIGSGGAIIIIYGLIIAGFFSLCVAVTLGELISAYTNPAGQYYWTLQLAPERYRKILAFITALFSYFGCVFTCASVSSSLANSILSSYVLNNPSFEIKRWHSFVTFEAINLALSVFNIWGRYLPHIVTSGLWISLIGFVVTMITCLACSSGRYNSGNFVFSDYTNITGWNNKALSFIIGLISPIWCFAGLDSAVHMVDDLGVKAGKVLIPRAVICTVALGFLTAFAYSVAIFFCATDVSEVVESTLPLLTIFYQSTKNKSAAIFLEVLTILTGIVCNISAHAWQARVCWTLAGSEALPGSKYLKQIHPRTKLPVNAHFFSTFLVAIIGCIYVGSTTAFNAIITACICLLLISYSIPAILLLRVRNKGFAHGPFWCGKLGYITNILTILWTIFCLVFLSFPYVRPVTNTNMNYVSAVYGGVILAVIICWFSYGKAKFIANKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSB9</accession>
    <name>A0A1D8PSB9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Srp40p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">SRP40</name>
        <name evidence="4" type="ordered locus">CAALFM_CR02980CA</name>
        <name evidence="3" type="ordered locus">orf19.10377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715790.1">
        <property type="nucleotide sequence ID" value="XM_710697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSB9"/>
    <dbReference type="STRING" id="237561.A0A1D8PSB9"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="428" mass="46908" checksum="AF980B4B21D577F7" modified="2017-01-18" version="1">MGECGWGEGIFSSQRKKRPRFVFGLISLSLSYSHKRRATIKVCPNGLEKNFFFNFFFHLLKSQLLQLLPIAKMSSNTQDLVLAYINDYVSRNEELSKLKKALSKFLAGKELPKVSKQLESIIDEVENQEKKSKPRNSSSDSEDSSSESESSTSDSESSSSDSDSSSSDSESSSSDSESSSSDSEDSDDEEDKEDKEAEKDNKDSEDSENEKVEEDNKDTSSDSSSSSDSKSDSDSDSSSSSDSSSDSDSSSDSDSSSSSDSDSSSSSDSDSDSDSDSDSDDNSSESSSEDEESSSDSESKEEQKQPEDKKRKHTDDIKEEKPVKKFKNESESSASSSTDSIPATPEPELKPGQRKHFSRIDRSKVNFENSVLQDNTYKGAAGTWGEKASEKLLQVRGKDFTKNKNKMKRGSYKGGSITLASGSYKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSC9</accession>
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        <name evidence="12" type="ordered locus">CAALFM_CR03040CA</name>
        <name evidence="11" type="ordered locus">orf19.9963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
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    </feature>
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            <end position="212"/>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
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            <begin position="16"/>
            <end position="486"/>
        </location>
    </feature>
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            <end position="287"/>
        </location>
    </feature>
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            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000201340"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="496" mass="53715" checksum="52BCF717D73B0D3D" modified="2017-01-18" version="1">MAISIPSGLTLNLISSVSVICLGSLQFGYHMAELNSPELVLSCKRSQPGPVPYRDSFFGRNGFKQCIPMTPDQIGLVTSIFSIGGLFGSFYVGHLADKYGRKKTSLLHCLLYIIGSTINGLSNTYASLLLGRFICGLGAGSALVITSIYINEVSPIETKGLLGSMNQFSINIGILFTQLLSLNWSNDNDWRWLLFMAAFIAVANVIVVSSYLNESPVWLANQGDTAEAFTILHRLRGGSYSVATDEVNSWKSQGRGTTPESDMLLEEGNGNEHNSGTGSSGAPGGNSNKNLVTVVDYVTLPEYRNSLIASTGILVLQQFDGINSIIFYGVSVLVSIFPNHSIIINCLISLVNVIVTFISATIVDKLGRKPLLLLSVSFLGIATVLMGLGIIWTSSLLSIAGTFTYITFFAIGMGPIPFLLVGEVTQPIAKASAQSWGTSMNWIATFIVGYTFPVLKEWLGGSVYFIFTVMCCVSVWFIKTKVPETKGKHSYQEVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT74</accession>
    <name>A0A1D8PT74_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR06380CA</name>
        <name evidence="2" type="ordered locus">orf19.8346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Federspiel N.A."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <dbReference type="eggNOG" id="KOG0173">
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    </dbReference>
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        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 14" id="KW-0647">Proteasome</keyword>
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    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
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            <begin position="222"/>
            <end position="257"/>
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    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
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        </source>
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    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000181985"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="272" mass="29407" checksum="6B130ABB9EF9AC76" modified="2017-01-18" version="1">MPGLNFDNYQRNAFLTSKGFATPKATSTGTTIVGCKFKDGVVIAADTRATSGPIVADKNCEKLHRLAPKIWCAGAGTAADTEMVTQLIASNLELHALSQNRQPRVIAALTMLKQHLFKYQGHLGAYLIVAGVDPTGAHLMSVQAHGSTDIGKYQSLGSGSLNAMAVLETNFKEDMTRDEAIKLCSDAILAGVWNDLGSGSNVDVCVMEVGKDAELYRNYITPNVRIKKCKDYKFPRGTTAVLKQSIRDICDVEETVVNFNDNGDNMEVDTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU87</accession>
    <name>A0A1D8PU87_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Telomere length regulation protein ELG1</fullName>
        </recommendedName>
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        <name evidence="4" type="ordered locus">CAALFM_CR10440WA</name>
        <name evidence="3" type="ordered locus">orf19.7621</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_714289.1"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PU87"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR10440WA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="103395" checksum="2EFA7B66066732B8" modified="2017-01-18" version="1">MEITGSEDTLKSPEIESNDGNKKVGNNLYSTTPSSLFNVLTGNQNTKKNTSTSKIRKDKDQSYGGDEKVVNGTTEKLENRPTSLTSKDIFRIYREKDKQKYTLPDDQEPPVHHQPHETHQAFPKDMICNSLEISDFTADIESKIFANKKSTTVKDLFNNFRPKKVVTIKLSPQILKNISPNPSNINLSKDSSTLPDSRPAFTAQDILQRRKHILPVHNTEKAATKIDSQLHTSDIERKIYGSKPKSSVQDILKRERNEHQIIKPQPVPRPTYFITLKVNSKHLAEIKQYDNPLITKGNKSNTKGKTGASLFASMMQASKSATKLESMQQLKNTIILPKALKREEFHIYEKEVLNPRKLLLEERNRNVRCDVDTKIFESFTDLFTRELTSRYHYQIKDKIDLRQYASSKLPNLSRSPALEFVFDMIGQPKQGMWTETFKPQKMNQLLIHKQNKNDIYNWISNSFLKLKSQAPIKNIKQKIKQRRQESFIVYDYEDEETEEEVYSPFLILQGSCGSGKSTAVFTAMNELDGFVHEINTGQNRGRKDIFANLKELCTTEVVRDTKEFHRGVILLEDVNVLFEQDKTFWSVVQEVINISKRPIVLTCEEIWNIPKNLIEFAQHDESIIFMDDYVISKNLVVDYLWLCCLVYNCDVARDILVEIIDDNWNGHNFDIRGCLMNCQIMCPNRPESLTVVTRVSDSSTKKALENINDVSHLLDINSCSDVIGVNSISQLAHTLQLNELDDVYWVDDSRNHTLPYELNIGKKLNHKLEGFELDFSVPERKFLMNDLRYEANRFIGSRMKYFSNSEFRRSTRSGGGESNAHLDTIGIPDTSFLNHIANSSFILDLLPMARLWSQFQNNIDQLEKEVLAEGKPSIKRFLRYRDFCHKTTLDATMNRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU88</accession>
    <name>A0A1D8PU88_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kleisin alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">MCD1</name>
        <name evidence="8" type="ordered locus">CAALFM_CR10540CA</name>
        <name evidence="7" type="ordered locus">orf19.7634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719394.2">
        <property type="nucleotide sequence ID" value="XM_714301.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU88"/>
    <dbReference type="SMR" id="A0A1D8PU88"/>
    <dbReference type="FunCoup" id="A0A1D8PU88">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU88"/>
    <dbReference type="GeneID" id="3639044"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10540CA"/>
    <dbReference type="CGD" id="CAL0000183738">
        <property type="gene designation" value="MCD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10540C_A"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU88"/>
    <dbReference type="OMA" id="IWLASNM"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000183738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW31703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="564" mass="63834" checksum="51983F8081A23B90" modified="2017-01-18" version="1">MIPDSIISKQGPLGHVWLAANYDKKLTKQQLMNTSIVKSTEYIANHPVITNVSVSQELPSDLDSTNTITLRLSGQLLLGIVRIYSRKTKYLLDDVNDILYKLKASFKLSSGVNLGSDNISNQVNLPPEQTILQNLNSIILKDQVTSANLLQQDDLDLSDIHGTSTGSGLDGMLNHNASQSSSEYSEYDNSIEFPRYEEEAAAPGHTEDFELDFDLNLDDDNSIEYGRDASVSINDREISIISDVHKERTTGDIFDLNFGQPLDDLNDDEAENEEDRQLPSNSEHQERSAESDLQPRRVRQKRTRITEDGQIITNNRKLVVDSEEAMEGLAIQQLKDNQEKILSGQDSAPYISLNLSDFEKLKLIEELAVPVATKKRKLWNLNAELQYRCAELALQEQQQHQQYEENNQQNDFHLDQSFDNDSMDFDLSLPDFDDQHSDNFSDAGILDDEVDEEDDTNYTHTARVTEQIGQELIELFKSSNTVEFEKLIETDSEIHHRNPDKLPLGVVSKNKDRINSRKEATKCFFELLVLATNNCISLGQIPQETTIAGDISITSRDRLFSQFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>P39827</accession>
    <accession>A0A1D8PSR7</accession>
    <accession>Q5A6K6</accession>
    <name>CDC10_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cell division control protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CDC10</name>
        <name type="ordered locus">CAALFM_CR04570CA</name>
        <name type="ORF">CaO19.548</name>
        <name type="ORF">CaO19.8183</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Mol. Gen. Genet." volume="242" first="689" last="698">
            <title>Homologs of the yeast neck filament associated genes: isolation and sequence analysis of Candida albicans CDC3 and CDC10.</title>
            <authorList>
                <person name="Didomenico B.J."/>
                <person name="Brown N.H."/>
                <person name="Lupisella J."/>
                <person name="Greene J.R."/>
                <person name="Yanko M."/>
                <person name="Koltin Y."/>
            </authorList>
            <dbReference type="PubMed" id="8152419"/>
            <dbReference type="DOI" id="10.1007/BF00283424"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>C792</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Plays a role in the cell cycle. Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
        <text evidence="1">Present at the bud neck during cell division.</text>
    </comment>
    <comment type="developmental stage">
        <text>Expressed at higher levels in cells growing as hyphae than in those growing as budding yeasts.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="Z25870">
        <property type="protein sequence ID" value="CAA81090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S43278">
        <property type="entry name" value="S43278"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717411.2">
        <property type="nucleotide sequence ID" value="XM_712318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P39827"/>
    <dbReference type="SMR" id="P39827"/>
    <dbReference type="BioGRID" id="1223999">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="FunCoup" id="P39827">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P39827"/>
    <dbReference type="EnsemblFungi" id="CR_04570C_A-T">
        <property type="protein sequence ID" value="CR_04570C_A-T-p1"/>
        <property type="gene ID" value="CR_04570C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640947"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04570CA"/>
    <dbReference type="CGD" id="CAL0000188354">
        <property type="gene designation" value="CDC10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04570C_A"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_1_1"/>
    <dbReference type="InParanoid" id="P39827"/>
    <dbReference type="OMA" id="QCEFVYL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PHI-base" id="PHI:281"/>
    <dbReference type="PRO" id="PR:P39827"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032175">
        <property type="term" value="C:mating projection septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036391">
        <property type="term" value="C:medial cortex septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032152">
        <property type="term" value="C:meiotic septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072687">
        <property type="term" value="C:meiotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032151">
        <property type="term" value="C:mitotic septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032169">
        <property type="term" value="C:prospore septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006033">
        <property type="term" value="P:chitin localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001410">
        <property type="term" value="P:chlamydospore formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070583">
        <property type="term" value="P:spore membrane bending pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000173497" description="Cell division control protein 10">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="34"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="2">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="2">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4 motif" evidence="2">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA81090." evidence="4" ref="1">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="357" mass="40684" checksum="7C25CC98376749E2" modified="2017-03-15" version="2">MSIEEPSTQHIAQPQKYVGFDTITTQIENRLLKRGFQFNIMVVGRSGLGKSTLVNTLFSSKLTTSQGRKSPSEPIEKTTEIKVASHSLLENNVRLNINVIDTPGFGDQINNEKCWEPLVKYVKEQHSQYLRKELTAQRDKFLADTRVHCILYFIPPNGQKLKQLDVQALKKLSEIANVVPIIAKSDSLTLDERSEFKKLLQSEFMKYNFNIYPYDSEDLYEEERQLNEDIKSLIPFAIAGSETEIEINGEMVRGRKTKWGAINIEDVSQCEFVFLRDFLTRTHLQDLIETTALTHYETFRSKQLIALKENASNPNRQSQLQKDQGQTSQQSNQDLKNTSGVPNAPMFQSTTGTAAAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>P48990</accession>
    <accession>A0A1D8PR89</accession>
    <accession>Q3MP44</accession>
    <accession>Q5A5D9</accession>
    <accession>Q5A5K8</accession>
    <name>TIM54_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM54</name>
        <name type="ordered locus">CAALFM_C703120WA</name>
        <name type="ORF">CaJ7.0359</name>
        <name type="ORF">CaO19.12608</name>
        <name type="ORF">CaO19.5143</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="Gene" volume="147" first="115" last="118">
            <title>Sequence of a dihydrofolate reductase-encoding gene from Candida albicans.</title>
            <authorList>
                <person name="Daly S."/>
                <person name="Mastromei G."/>
                <person name="Yacoub A."/>
                <person name="Lorenzetti R."/>
            </authorList>
            <dbReference type="PubMed" id="7916311"/>
            <dbReference type="DOI" id="10.1016/0378-1119(94)90049-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 283-400</scope>
        <source>
            <strain>10127/5</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X78968">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716966.2">
        <property type="nucleotide sequence ID" value="XM_711873.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P48990"/>
    <dbReference type="SMR" id="P48990"/>
    <dbReference type="FunCoup" id="P48990">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P48990"/>
    <dbReference type="EnsemblFungi" id="C7_03120W_A-T">
        <property type="protein sequence ID" value="C7_03120W_A-T-p1"/>
        <property type="gene ID" value="C7_03120W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641349"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703120WA"/>
    <dbReference type="CGD" id="CAL0000174120">
        <property type="gene designation" value="TIM54"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03120W_A"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039097_0_0_1"/>
    <dbReference type="InParanoid" id="P48990"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000203063" description="Mitochondrial import inner membrane translocase subunit TIM54">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="50"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAE44816." evidence="4" ref="1">
        <original>K</original>
        <variation>Q</variation>
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; X78968." evidence="4" ref="5">
        <original>AP</original>
        <variation>EF</variation>
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; X78968." evidence="4" ref="5">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; X78968." evidence="4" ref="5">
        <original>L</original>
        <variation>I</variation>
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; X78968." evidence="4" ref="5">
        <original>M</original>
        <variation>I</variation>
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="400" mass="46113" checksum="B41D82C7373EBAD9" modified="2017-03-15" version="3">MPDANEVKPKKGWSNPALRMMGIPRISLPSRNWMIFWTVVTTIGGGIAYDKYEQKQMRKKWMDAVKQFGEVSYGANEIPRKLSIFIAPPPNDFLDESLKLFRKFIKPVLNAGVVDFEIFSESRQGDIRASVAEKIRELRRKQLVEETPKKNESNGNQDNDEEELKSRSDLYKAKDVLGLYKVFPADINVKSEDAIDDSSAGGIICVGRGAYKEYLSGVHEGLLGPLEKPQSVIDEETKLAEEKKKEKEENPDKDDDNDEEQSNLKPVPLRYIKPEDYANAQLAPELDLSTVVKDDKGVPVFFEQPVYTFPLPNLVGFTNIPRKIYRYFTKRFLVDDFGERTATIVNNKSRPFVYKDVLMAKEEEMDWPKKWVEKGKERNSEWVQELEHDERVTSRMKVFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>P53704</accession>
    <accession>A0A1D8PJE2</accession>
    <accession>Q5AJV2</accession>
    <name>GFA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <shortName>GFAT</shortName>
            <ecNumber>2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GFA1</name>
        <name type="ordered locus">CAALFM_C302280CA</name>
        <name type="ORF">CaO19.1618</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="2320" last="2327">
            <title>Isolation and characterization of the GFA1 gene encoding the glutamine:fructose-6-phosphate amidotransferase of Candida albicans.</title>
            <authorList>
                <person name="Smith R.J."/>
                <person name="Milewski S."/>
                <person name="Brown A.J."/>
                <person name="Gooday G.W."/>
            </authorList>
            <dbReference type="PubMed" id="8636033"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10261 / CBS 2718 / NBRC 1061</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="J. Mol. Biol." volume="372" first="672" last="688">
            <title>The crystal and solution studies of glucosamine-6-phosphate synthase from Candida albicans.</title>
            <authorList>
                <person name="Raczynska J."/>
                <person name="Olchowy J."/>
                <person name="Konariev P.V."/>
                <person name="Svergun D.I."/>
                <person name="Milewski S."/>
                <person name="Rypniewski W."/>
            </authorList>
            <dbReference type="PubMed" id="17681543"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2007.07.002"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 347-713</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16"/>
    <dbReference type="EMBL" id="X94753">
        <property type="protein sequence ID" value="CAA64380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PIR" id="JC6012">
        <property type="entry name" value="JC6012"/>
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    <dbReference type="RefSeq" id="XP_721697.2">
        <property type="nucleotide sequence ID" value="XM_716604.2"/>
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    <dbReference type="PDB" id="2POC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B/C/D=347-713"/>
    </dbReference>
    <dbReference type="PDB" id="2PUT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B/C/D=347-713"/>
    </dbReference>
    <dbReference type="PDB" id="2PUV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B/C/D=347-713"/>
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    <dbReference type="PDB" id="2PUW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.15 A"/>
        <property type="chains" value="A/B=347-713"/>
    </dbReference>
    <dbReference type="PDBsum" id="2POC"/>
    <dbReference type="PDBsum" id="2PUT"/>
    <dbReference type="PDBsum" id="2PUV"/>
    <dbReference type="PDBsum" id="2PUW"/>
    <dbReference type="AlphaFoldDB" id="P53704"/>
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        <property type="interactions" value="6"/>
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    <dbReference type="FunCoup" id="P53704">
        <property type="interactions" value="1123"/>
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    <dbReference type="STRING" id="237561.P53704"/>
    <dbReference type="BindingDB" id="P53704"/>
    <dbReference type="EnsemblFungi" id="C3_02280C_A-T">
        <property type="protein sequence ID" value="C3_02280C_A-T-p1"/>
        <property type="gene ID" value="C3_02280C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636557"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302280CA"/>
    <dbReference type="CGD" id="CAL0000176261">
        <property type="gene designation" value="GFA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02280C_A"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="InParanoid" id="P53704"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-13172"/>
    <dbReference type="BRENDA" id="2.6.1.16">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="P53704"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006042">
        <property type="term" value="P:glucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
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    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
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    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
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    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
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    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
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    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000135287" description="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]">
        <location>
            <begin position="2"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="316"/>
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    </feature>
    <feature type="domain" description="SIS 1" evidence="3">
        <location>
            <begin position="389"/>
            <end position="528"/>
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    </feature>
    <feature type="domain" description="SIS 2" evidence="3">
        <location>
            <begin position="561"/>
            <end position="703"/>
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    </feature>
    <feature type="active site" description="For GATase activity" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA64380." evidence="5" ref="1">
        <original>K</original>
        <variation>R</variation>
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA64380." evidence="5" ref="1">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="63"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="354"/>
            <end position="360"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="362"/>
            <end position="370"/>
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    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="371"/>
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    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="376"/>
            <end position="379"/>
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    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="384"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="387"/>
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        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="390"/>
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        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="396"/>
            <end position="403"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="405"/>
            <end position="422"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="426"/>
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    </feature>
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        <location>
            <begin position="431"/>
            <end position="436"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="445"/>
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        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="472"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="483"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="488"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="501"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="523"/>
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    </feature>
    <feature type="turn" evidence="7">
        <location>
            <begin position="527"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="551"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="554"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="564"/>
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        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="569"/>
            <end position="575"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="577"/>
            <end position="579"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="580"/>
            <end position="594"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="597"/>
            <end position="602"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="607"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="610"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="620"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="626"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="631"/>
            <end position="642"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="648"/>
            <end position="652"/>
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    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="665"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="674"/>
            <end position="676"/>
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    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="677"/>
            <end position="695"/>
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    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00609"/>
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    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00797"/>
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    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17681543"/>
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    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2POC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="2PUW"/>
        </source>
    </evidence>
    <sequence length="713" mass="79254" checksum="390C6B8AE756C5E2" modified="2017-03-15" version="3">MCGIFGYVNFLVDKSKGEIIDNLIEGLQRLEYRGYDSAGIAVDGKLTKDPSNGDEEYMDSIIIKTTGKVKVLKQKIIDDQIDRSAIFDNHVGIAHTRWATHGQPKTENCHPHKSDPKGEFIVVHNGIITNYAALRKYLLSKGHVFESETDTECIAKLFKHFYDLNVKAGVFPDLNELTKQVLHELEGSYGLLVKSYHYPGEVCGTRKGSPLLVGVKTDKKLKVDFVDVEFEAQQQHRPQQPQINHNGATSAAELGFIPVAPGEQNLRTSQSRAFLSEDDLPMPVEFFLSSDPASVVQHTKKVLFLEDDDIAHIYDGELRIHRASTKSAGESTVRPIQTLEMELNEIMKGPYKHFMQKEIFEQPDSAFNTMRGRIDFENCVVTLGGLKSWLSTIRRCRRIIMIACGTSYHSCLATRSIFEELTEIPVSVELASDFLDRRSPVFRDDTCVFVSQSGETADSILALQYCLERGALTVGIVNSVGSSMSRQTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSNDSISRKGRHEEIIKGLQKIPEQIKQVLKLENKIKDLCNSSLNDQKSLLLLGRGYQFATALEGALKIKEISYMHSEGVLAGELKHGILALVDEDLPIIAFATRDSLFPKVMSAIEQVTARDGRPIVICNEGDAIISNDKVHTTLEVPETVDCLQGLLNVIPLQLISYWLAVNRGIDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-06-18" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>P87220</accession>
    <accession>A0A1D8PMK5</accession>
    <accession>Q5A1C4</accession>
    <name>VATD_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>V-type proton ATPase subunit D</fullName>
            <shortName>V-ATPase subunit D</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">VMA8</name>
        <name type="ordered locus">CAALFM_C406400CA</name>
        <name type="ORF">CaO19.10413</name>
        <name type="ORF">CaO19.2895</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Janbon G."/>
                <person name="Rustchenko E."/>
                <person name="Sherman F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SOR17</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AF002134">
        <property type="protein sequence ID" value="AAC24464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715551.1">
        <property type="nucleotide sequence ID" value="XM_710458.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P87220"/>
    <dbReference type="SMR" id="P87220"/>
    <dbReference type="FunCoup" id="P87220">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P87220"/>
    <dbReference type="EnsemblFungi" id="C4_06400C_A-T">
        <property type="protein sequence ID" value="C4_06400C_A-T-p1"/>
        <property type="gene ID" value="C4_06400C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642798"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406400CA"/>
    <dbReference type="CGD" id="CAL0000187911">
        <property type="gene designation" value="VMA8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06400C_A"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="InParanoid" id="P87220"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="PRO" id="PR:P87220"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000144241" description="V-type proton ATPase subunit D">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="267" mass="30020" checksum="A3FD502524A2C39C" modified="1997-07-01" version="1">MSGAGNREQVFPTRMTLGVMKSKLKGAQQGHSLLKRKSEALTKRFRDITQRIDDAKRKMGRVMQTAAFSLAEVQYATGDNISYQVQESVQKARFTVKAKQENVSGVFLPTFDSHINEDVNDFKLTALARGGQQVQKAKLIYSKAVETLVELASLQTAFIILDEVIKITNRRVNAIEHVIIPRTENTIAYINGELDEMDREEFYRLKKVQEKKQEAAAAAEQEEALAKAKAEGATDELAIQQDVEALDIKADKEEVDILQEKEDDVIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KZ1</accession>
    <accession>A0A1D8PDA3</accession>
    <name>APE2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Aminopeptidase 2</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">APE2</name>
        <name type="ordered locus">CAALFM_C104400CA</name>
        <name type="ORF">CaO19.12664</name>
        <name type="ORF">CaO19.5197</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="FEMS Yeast Res." volume="8" first="858" last="869">
            <title>Identification and characterization of CaApe2 -- a neutral arginine/alanine/leucine-specific metallo-aminopeptidase from Candida albicans.</title>
            <authorList>
                <person name="Klinke T."/>
                <person name="Rump A."/>
                <person name="Poenisch R."/>
                <person name="Schellenberger W."/>
                <person name="Mueller E.-C."/>
                <person name="Otto A."/>
                <person name="Klimm W."/>
                <person name="Kriegel T.M."/>
            </authorList>
            <dbReference type="PubMed" id="18637841"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2008.00411.x"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 58-70</scope>
        <scope>ACETYLATION AT SER-58</scope>
        <scope>GENE MODEL REVISION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>ATCC 2091 / CBS 2730 / DSM 1665 / CIP 1180.79 / NBRC 1393</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Metalloprotease that specifically hydrolyzes peptides with N-terminal alanine, arginine and leucine residues.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text>Inactivated by metal-chelating agents phenanthroline and EDTA. Inhibited by bestatin, an aminopeptidase inhibitor. Not inhibited by pepstatin A and PMSF, inhibitors of aspartic and the serine proteases, respectively. Not inhibited by carboxypeptidase inhibitor.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">457 uM for L-alanine-AMC</KM>
            <KM evidence="4">46.9 uM for L-arginine-AMC</KM>
            <KM evidence="4">82 uM for L-leucine-AMC</KM>
            <Vmax evidence="4">16.9 umol/min/mg enzyme for L-alanine-AMC</Vmax>
            <Vmax evidence="4">25.4 umol/min/mg enzyme for L-arginine-AMC</Vmax>
            <Vmax evidence="4">18.4 umol/min/mg enzyme for L-leucine-AMC</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="4">Optimum pH is 7.2.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="4">Optimum temperature is 30 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330640.1">
        <property type="nucleotide sequence ID" value="XM_019475095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KZ1"/>
    <dbReference type="SMR" id="Q59KZ1"/>
    <dbReference type="FunCoup" id="Q59KZ1">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59KZ1"/>
    <dbReference type="MEROPS" id="M01.006"/>
    <dbReference type="GlyCosmos" id="Q59KZ1">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="iPTMnet" id="Q59KZ1"/>
    <dbReference type="EnsemblFungi" id="C1_04400C_A-T">
        <property type="protein sequence ID" value="C1_04400C_A-T-p1"/>
        <property type="gene ID" value="C1_04400C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647990"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104400CA"/>
    <dbReference type="CGD" id="CAL0000186164">
        <property type="gene designation" value="APE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04400C_A"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="InParanoid" id="Q59KZ1"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="PRO" id="PR:Q59KZ1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000434587" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000370249" description="Aminopeptidase 2">
        <location>
            <begin position="58"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="327"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylserine; partial" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AA sequence." evidence="6" ref="4">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18637841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="18637841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="924" mass="104382" checksum="43EE4E58B565BCE8" modified="2017-03-15" version="3" precursor="true">MASNNTSQRSGFSSFFCRLKTYFCNHFLCLFVLSFFPLSFRRLCLLCHLCEKSNLWLSSDNSASVVKQEREVLPTNVKPLHYDLTIEPIFDNFTFKGEETIDFQVNEKTNFITLNSLEIEVQEAKIDGKSVTDISFDAGKQTVTFKFDDDLSTGSIAKLYIKFTGELNDKMAGFYRASYQEDGKTKYMATTQMEPTDCRRAFPSYDEPAAKSKFTISLIADKELVCLSNSSEKETVSLDGNKKKVTFQTTPLMSTYLVAFIVGDLRYISNDNYRVPIRVYSTPGTEHLGEYSANIAAQTLKFFDQQFGIDYPYDKLDMVAVPSFSAGAMENCGLVTFRTVDLLIDADNANVNTKQRVTEVVMHELAHQWFGDLVTMEFWDGLWLNEGFATWMSWYACNSLYPDWKVWESYVSDSLQHALTLDALRASHPIEVPVKRADEINQIFDAISYSKGSSLLRMISKWLGEDVFVKGVSNYLKKHKWGNTKTSDLWEALSEASGEDVVKVMDIWTKNIGFPIVKVEEIGNGEIKVTQNRFLATGDVKESEDKTLYPVFLGLKTSEGVDESSVLETRSKTIKLPTSDDFFKINGDQSGIYRTAYEPARWTKLGKAGVEGKLSVEDRVGLVADAGSLASSGFIKTSSLLDLVKSWSKESNYVVWNEILTRIGSIKAALMFEDEATKKALEIFTRDLISEKLKETGWEFSADDSFADQQLKSSLFASAANAEDPEAVAFAKEAFAKFIAGDKKAIHPNLRASIFNTNAKYGDEKTFDELYNIYRNPSSVEEKIAALRSFGRFTKPEILDKVTGLLLQTDIVKQQDIYIPMQGLRAHKLGVEKLWTWLSENWDQIYILLPPGLSMLGSVVTLGTSGFTKEEQKKKVEEFFAQKDNKGYDQSLAQSLDIITAKSKWTDRDAKSIYEWLEANEYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LX0</accession>
    <name>Q59LX0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vitamin B6 transporter TPN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transport of pyridoxine protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">FCY23</name>
        <name evidence="13" type="ordered locus">CAALFM_C110610WA</name>
        <name evidence="12" type="ordered locus">orf19.9390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710716.1">
        <property type="nucleotide sequence ID" value="XM_705624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LX0"/>
    <dbReference type="FunCoup" id="Q59LX0">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LX0"/>
    <dbReference type="GeneID" id="3647681"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110610WA"/>
    <dbReference type="CGD" id="CAL0000191201">
        <property type="gene designation" value="FCY23"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10610W_A"/>
    <dbReference type="eggNOG" id="ENOG502QR29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="InParanoid" id="Q59LX0"/>
    <dbReference type="OMA" id="AFGRYSM"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051180">
        <property type="term" value="P:vitamin transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000007">
        <property type="entry name" value="Pyridoxine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF17">
        <property type="entry name" value="VITAMIN B6 TRANSPORTER TPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000191201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW26688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="597" mass="65912" checksum="35478BDD0ED92567" modified="2005-04-26" version="1">MSKIKNNSPTIKQRPTGVTTTNSSSSIDVVTTSAPRYEDNFFNDETTHEITSETNSTSSSSTIFQYLATISKKLDSLGVETRGIERIQPYERSTNRTKQFISVMGLWLSACGGLSSMSSFYLGPLLFELGLRNTLLAGLLGEILGCFIAAYCSLMGPRSGCRQMVSGRFLFGWWFVKLVALVAIIGVMGWSVVNSVVGGQILSSVSDDKIPLWAGIVIIAAISLIVAIAGIKQLIRVEAFLSIPVNCAFLLLYIVASQKFDYLTWKDAVVATEGSEYSAAATVKGNWLSFFSLCYSITSTWGTIASDYYILFPENTPDWEIFAITFFGISIPTTFVGVAGILIGNVALTYQPWGDAYKKLGMGGLLNEAFKPWGAGGKFLLMIIFLSLISNNIINTYSAAFGVQLAGTMFAKVPRWLWAILLTAIYLICALVGRNEFSTILGNFLPMIGYWVSMYFIMLLEENTIFRTDKFKYLFTKEFPRVNKEEEQEEEDGLDSSIVHHPIDARIIGTPLRQNQHYNFSIWNDYDKLTQGLAATASFIIGATGAAVGMSQAYWIGPLARRIGGEFGGDIAMWLCMGFSGLVYPPLRYLELKKFGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q59N80</accession>
    <accession>A0A1D8PNT0</accession>
    <name>ITPA_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">ITPase</shortName>
            <shortName evidence="1">Inosine triphosphatase</shortName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HAM1</name>
        <name type="ordered locus">CAALFM_C503860WA</name>
        <name type="ORF">CaO19.1108</name>
        <name type="ORF">CaO19.8705</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28611"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711160.1">
        <property type="nucleotide sequence ID" value="XM_706068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59N80"/>
    <dbReference type="SMR" id="Q59N80"/>
    <dbReference type="BioGRID" id="1230305">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59N80">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59N80"/>
    <dbReference type="EnsemblFungi" id="C5_03860W_A-T">
        <property type="protein sequence ID" value="C5_03860W_A-T-p1"/>
        <property type="gene ID" value="C5_03860W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647224"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503860WA"/>
    <dbReference type="CGD" id="CAL0000174774">
        <property type="gene designation" value="HAM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03860W_A"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="InParanoid" id="Q59N80"/>
    <dbReference type="OMA" id="YDPIFQP"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="PRO" id="PR:Q59N80"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000009">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413130" description="Inosine triphosphate pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <sequence length="202" mass="22036" checksum="863C0FC44B95D11E" modified="2005-04-26" version="1">MSTITFVTGNANKLKEVIAILASSETDSSSSSSSLSSSNKVGKFTITNQSVDLDEVQGTIEQVTIHKAQAAAKVIDGPVLVEDTCLGFNAFNDLPGPYIKWFVQSIGLTGLVKMLIGFEDKSAKAICTFGYCEGPDKEVKIFQGITEGKIVDSRGPTNFGWDSIFQPNGFEQTYAEMDKKVKNSISHRYKALDKVRDYLLSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NY7</accession>
    <accession>A0A1D8PNQ0</accession>
    <name>CUE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CUE1</name>
        <name type="ordered locus">CAALFM_C503570WA</name>
        <name type="ORF">CaO19.6668</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with UBC7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CUE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711420.2">
        <property type="nucleotide sequence ID" value="XM_706328.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NY7"/>
    <dbReference type="SMR" id="Q59NY7"/>
    <dbReference type="FunCoup" id="Q59NY7">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59NY7"/>
    <dbReference type="PeptideAtlas" id="Q59NY7"/>
    <dbReference type="GeneID" id="3646976"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503570WA"/>
    <dbReference type="eggNOG" id="ENOG502S35Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115919_0_0_1"/>
    <dbReference type="InParanoid" id="Q59NY7"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00014">
        <property type="entry name" value="ER_TARGET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000280670" description="Coupling of ubiquitin conjugation to ER degradation protein 1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="189" mass="21236" checksum="FFC72E82CE0C3317" modified="2017-03-15" version="3">MDSSTVLFIGAVAVAFIFLKWMVSPIPPQNEFTIDHLSQDQSTGSTTSSNAHQNRDTHSISTQSHRNSRRAVSESMIEVVQSIAPMLTVEQIRYDLETTGNVEATVNRFMELGDLPFPPGYVRPQQPPTPSEEPKKQEVIGKRSVNLLEKYNIDAKNPKSDHNSLLHQRRQEMILGARKRLAAQLSNEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-04-09" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P39</accession>
    <accession>A0A1D8PHR3</accession>
    <name>EFH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator EFH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>EFG1 homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EFH1</name>
        <name type="synonym">PHD1</name>
        <name type="ordered locus">CAALFM_C206340WA</name>
        <name type="ORF">CaO19.12953</name>
        <name type="ORF">CaO19.5498</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Mol. Biol." volume="329" first="949" last="962">
            <title>Adaptation of the Efg1p morphogenetic pathway in Candida albicans by negative autoregulation and PKA-dependent repression of the EFG1 gene.</title>
            <authorList>
                <person name="Tebarth B."/>
                <person name="Doedt T."/>
                <person name="Krishnamurthy S."/>
                <person name="Weide M."/>
                <person name="Monterola F."/>
                <person name="Dominguez A."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="12798685"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(03)00505-9"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Mol. Biol. Cell" volume="15" first="3167" last="3180">
            <title>APSES proteins regulate morphogenesis and metabolism in Candida albicans.</title>
            <authorList>
                <person name="Doedt T."/>
                <person name="Krishnamurthy S."/>
                <person name="Bockmuhl D.P."/>
                <person name="Tebarth B."/>
                <person name="Stempel C."/>
                <person name="Russell C.L."/>
                <person name="Brown A.J."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="15218092"/>
            <dbReference type="DOI" id="10.1091/10.1091/mbc.E03-11-0782"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2007" name="PLoS Pathog." volume="3" first="E184" last="E184">
            <title>Self-regulation of Candida albicans population size during GI colonization.</title>
            <authorList>
                <person name="White S.J."/>
                <person name="Rosenbach A."/>
                <person name="Lephart P."/>
                <person name="Nguyen D."/>
                <person name="Benjamin A."/>
                <person name="Tzipori S."/>
                <person name="Whiteway M."/>
                <person name="Mecsas J."/>
                <person name="Kumamoto C.A."/>
            </authorList>
            <dbReference type="PubMed" id="18069889"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.0030184"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Exhibits increased colonization of the murine intestinal tract, a model of commensal colonization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711489.1">
        <property type="nucleotide sequence ID" value="XM_706397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P39"/>
    <dbReference type="SMR" id="Q59P39"/>
    <dbReference type="BioGRID" id="1229991">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59P39"/>
    <dbReference type="EnsemblFungi" id="C2_06340W_A-T">
        <property type="protein sequence ID" value="C2_06340W_A-T-p1"/>
        <property type="gene ID" value="C2_06340W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646929"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206340WA"/>
    <dbReference type="CGD" id="CAL0000182054">
        <property type="gene designation" value="EFH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06340W_A"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428924_0_0_1"/>
    <dbReference type="InParanoid" id="Q59P39"/>
    <dbReference type="OMA" id="DENTNCY"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="PHI-base" id="PHI:123269"/>
    <dbReference type="PRO" id="PR:Q59P39"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900241">
        <property type="term" value="P:positive regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000426078" description="Transcriptional regulator EFH1">
        <location>
            <begin position="1"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="1">
        <location>
            <begin position="446"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12798685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15218092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18069889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="720" mass="81374" checksum="69EDE69293F7EFE8" modified="2005-04-26" version="1">MNGIMTTSSHSNFYNQDLVGAPSSSDHIPGPSSQDQPTNNNSPQHHHQHDQSQTTHQNHPLNQPIHHHPTQQNQSESQQSRQSHHLQQQQQQQQQQQQNQHNQQNLASSSTSYEMPSIYQQFTGSYQQTRVPKNFLLENANYYTLQPGFPLVQAADYYSTPTTTSANDYQNSTINSIISPSFQMGSVSTPDTQNSSIRSKQQQQHSYQQQQPQQLSQSQHQSQVPDIFYTQGGTIGGYVTTKQQQKEFSRKTSGDQTLVPQTNSKLQQQISETSYSQQQQQQQSPPTPQKQQQQQHYQHQTTQPYGGTGFMLYSQTGGPSSSPVAGNISIPTTIATTGQPNSQFQFTYGSPQQGSSSKTNQMYLYQRQQQQQQQHQQPQSQQMSQISQLSQQIPPQGSSKNISINSTPTKSRASSITTRSGRQSRSTSISSFIPQPDYPERVIRPKVATTRWDDENTNCYQVRARNILVSRREDTNYINGTKLLNVIGMTRGKRDGILKTEKIKNVVKVGSMNLKGVWIPFDRAYEIARNEGVDSLLYPLFVKNIKQYFLTKGHKLKSEDDEQEILEEGMTRQREEVRREGRSNGVGDFHNEEEEEIVGIQEDAGPNTAENDVPGDDEEEEDDDDDDDDDEEEGEQDDEEEEDGSSTSMSSSKNSESKLLETRDVIKSIVEEGDSTTGNVSEVKYVHEYLERSPQSTAIKEEDLYYGSSHNTPLTVHKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P48</accession>
    <name>Q59P48_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C206260WA</name>
        <name evidence="7" type="ordered locus">orf19.12943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711480.1">
        <property type="nucleotide sequence ID" value="XM_706388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P48"/>
    <dbReference type="SMR" id="Q59P48"/>
    <dbReference type="FunCoup" id="Q59P48">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59P48"/>
    <dbReference type="GeneID" id="3646913"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206260WA"/>
    <dbReference type="CGD" id="CAL0000180582">
        <property type="gene designation" value="orf19.12943"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06260W_A"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_4_0_1"/>
    <dbReference type="InParanoid" id="Q59P48"/>
    <dbReference type="OMA" id="IIWDDDV"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000180582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="171" mass="19644" checksum="ACD5727B6CF89CEB" modified="2005-04-26" version="1">MSSRINLFRSLFTSNSLKYGIPKKNKLPPRPKHLIKEEDIEEKFLHGGRGPGGQKINKTNSKVQLTHIPTGMVVSCQATRSQEQNRAIAREKLALKLDDFYNPGTSRNAVLMERAQKVKQSKSKKSNRKYKKVEDENIQKQMELSKLEESLNIKDIDDEFDDFIKNAKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PW1</accession>
    <name>Q59PW1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C107630WA</name>
        <name evidence="9" type="ordered locus">orf19.10298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711724.1">
        <property type="nucleotide sequence ID" value="XM_706632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PW1"/>
    <dbReference type="SMR" id="Q59PW1"/>
    <dbReference type="FunCoup" id="Q59PW1">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59PW1"/>
    <dbReference type="GeneID" id="3646660"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107630WA"/>
    <dbReference type="CGD" id="CAL0000183749">
        <property type="gene designation" value="orf19.10298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07630W_A"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_2_0_1"/>
    <dbReference type="InParanoid" id="Q59PW1"/>
    <dbReference type="OMA" id="TKLMPQC"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000183749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="175" mass="19444" checksum="D79C5445CC4C0D62" modified="2005-04-26" version="1">MFRRSLLSTSRFINKSSSSLSPGLLLNNFRGNFQQSRFISTELKDALDKAVTTSPVVLFMKGTPEFPQCGFSRATIQILGQQGVDPEKFAAYNVLEDSELREGIKEYSSWPTIPQLYVNGEFIGGCDIITSMAQNGELAELLEESNALIPEENEPTTSEENQETVQSANIKPNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QT0</accession>
    <name>Q59QT0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">RPO26</name>
        <name evidence="10" type="ordered locus">CAALFM_C503360WA</name>
        <name evidence="9" type="ordered locus">orf19.10166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712026.1">
        <property type="nucleotide sequence ID" value="XM_706933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QT0"/>
    <dbReference type="SMR" id="Q59QT0"/>
    <dbReference type="FunCoup" id="Q59QT0">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59QT0"/>
    <dbReference type="GeneID" id="3646351"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503360WA"/>
    <dbReference type="CGD" id="CAL0000199338">
        <property type="gene designation" value="RPO26"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03360W_A"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_1_1"/>
    <dbReference type="InParanoid" id="Q59QT0"/>
    <dbReference type="OMA" id="FEDWGCD"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
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        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000199338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="157" mass="17514" checksum="15F52BED1DB54149" modified="2005-04-26" version="1">MSDYEDNAFNEVAENFEDFDAPDHFSDNEYDDPSANGGDAALKTTDGRTIINGGFGPDDAQAAGQPRKKTTKELAIPKEKRTTTPYMTKYERARILGTRALQISLNAPVLVDIEGETDPLQIAMKELAQRKIPLVIRRYLPDGSYEDWGCDELIVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QW9</accession>
    <name>Q59QW9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C604320CA</name>
        <name evidence="2" type="ordered locus">orf19.8691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712103.1">
        <property type="nucleotide sequence ID" value="XM_707010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QW9"/>
    <dbReference type="SMR" id="Q59QW9"/>
    <dbReference type="GeneID" id="3646289"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604320CA"/>
    <dbReference type="CGD" id="CAL0000192997">
        <property type="gene designation" value="orf19.8691"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04320C_A"/>
    <dbReference type="HOGENOM" id="CLU_2209698_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QW9"/>
    <dbReference type="OrthoDB" id="4024478at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="115" mass="13442" checksum="1E6A34BF1D131114" modified="2005-04-26" version="1">MIPSMTIDQLIESKWYETYESYSINHNLPIDKTIKSSLPSITQEQQQQQQQQQQQQEQVPTQTPEIDLTNDIPNIIKLINKQSNVKELSTELTNVLLKYYWVGFDTGYECCNSNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RG0</accession>
    <name>NAG4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily multidrug transporter NAG4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acetylglucosamine utilization protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NAG4</name>
        <name type="synonym">GAN4</name>
        <name type="synonym">IFY1</name>
        <name evidence="9" type="synonym">TMP2</name>
        <name type="ordered locus">CAALFM_C604620CA</name>
        <name type="ORF">Aorf19.2160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Eur. J. Biochem." volume="268" first="2498" last="2505">
            <title>Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans.</title>
            <authorList>
                <person name="Yamada-Okabe T."/>
                <person name="Sakamori Y."/>
                <person name="Mio T."/>
                <person name="Yamada-Okabe H."/>
            </authorList>
            <dbReference type="PubMed" id="11298769"/>
            <dbReference type="DOI" id="10.1046/j.1432-1327.2001.02135.x"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="FEMS Microbiol. Lett." volume="212" first="15" last="21">
            <title>Characterization of the CaNAG3, CaNAG4, and CaNAG6 genes of the pathogenic fungus Candida albicans: possible involvement of these genes in the susceptibilities of cytotoxic agents.</title>
            <authorList>
                <person name="Yamada-Okabe T."/>
                <person name="Yamada-Okabe H."/>
            </authorList>
            <dbReference type="PubMed" id="12076781"/>
            <dbReference type="DOI" id="10.1111/j.1574-6968.2002.tb11238.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Biochem. Biophys. Res. Commun." volume="301" first="1099" last="1108">
            <title>Two membrane proteins located in the Nag regulon of Candida albicans confer multidrug resistance.</title>
            <authorList>
                <person name="Sengupta M."/>
                <person name="Datta A."/>
            </authorList>
            <dbReference type="PubMed" id="12589826"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Appl. Environ. Microbiol." volume="75" first="5840" last="5845">
            <title>N-acetylglucosamine utilization by Saccharomyces cerevisiae based on expression of Candida albicans NAG genes.</title>
            <authorList>
                <person name="Wendland J."/>
                <person name="Schaub Y."/>
                <person name="Walther A."/>
            </authorList>
            <dbReference type="PubMed" id="19648376"/>
            <dbReference type="DOI" id="10.1128/AEM.00053-09"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2015" name="Mol. Microbiol." volume="96" first="1226" last="1239">
            <title>An expanded regulatory network temporally controls Candida albicans biofilm formation.</title>
            <authorList>
                <person name="Fox E.P."/>
                <person name="Bui C.K."/>
                <person name="Nett J.E."/>
                <person name="Hartooni N."/>
                <person name="Mui M.C."/>
                <person name="Andes D.R."/>
                <person name="Nobile C.J."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="25784162"/>
            <dbReference type="DOI" id="10.1111/mmi.13002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">MFS transporter involved in N-acetylglucosamine (GlcNAc) uptake (PubMed:19648376). Confers resistance to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, and contributes to virulence (PubMed:12076781, PubMed:12589826).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5 7">Expression is induced in presence of cycloheximide and 4-nitroquinoline-N-oxide (PubMed:12589826). Expression is up-regulated during biofilm formation (PubMed:25784162).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to increased susceptibility to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, but not to actinomycin D, fluconazole, ketoconazole and colchicine (PubMed:12076781). Also leads to attenuated virulence in mice (PubMed:12076781).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712435.1">
        <property type="nucleotide sequence ID" value="XM_707342.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RG0"/>
    <dbReference type="STRING" id="237561.Q59RG0"/>
    <dbReference type="GlyCosmos" id="Q59RG0">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_04620C_A-T">
        <property type="protein sequence ID" value="C6_04620C_A-T-p1"/>
        <property type="gene ID" value="C6_04620C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645978"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604620CA"/>
    <dbReference type="CGD" id="CAL0000197244">
        <property type="gene designation" value="NAG4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04620C_A"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="InParanoid" id="Q59RG0"/>
    <dbReference type="OMA" id="TIYMAIC"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PHI-base" id="PHI:511"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008645">
        <property type="term" value="P:hexose transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000445246" description="Major facilitator superfamily multidrug transporter NAG4">
        <location>
            <begin position="1"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
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            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12076781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12589826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19648376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="25784162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="12076781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="12589826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="581" mass="64592" checksum="F680DCB429ECF553" modified="2005-04-26" version="1">MSHATDSTLDNASVDSEKVRDFGDDLQNHPVQPTRSILSKIRSRDDDARSLVSNNKGVERIISDLQEGAGQLGPLEQPYDIKKIETHPDPHTDYNEADPWKYPIDSESGLRLVEWVDGDKHNPKNISKAKKWLYTLVLGAVCFVVALGSAIVTGDMERPAEYFGVSEEVIILASVTVFVIGFGVGPLVFAPMSEEVGRKPIYVVTLFIAVVFIVPCGAAKNIATLIVCRLIDGIAFSAPMTLIGGSLADIWEGPERGTAMAIFSAAPFLGPVCGPIFGGLLCDHAPTWRWIYWTFLIVAGVFYAIFIAIVPETHHGILLKKRAKKLRKETGDSRYRSFNELQIRSFGEVAKTSLLRPFVLLSELIVFLMTIYMAICYGLLYMFFFAYPVVYQQGKGWSASLTGVMFIPIGVGVIIATIAAPFFNKDYNRRAQVYRDRGELPPPELRLIPMMIACWFVPVGLFAFAWSSYTWVSWAGPCFSGLAAGFGFCCLYNPANNYIVDSYQHYAASALAAKTFVRSIWGACVPLFTIQMYHRLGDQWATSLMAFISLACCAIPYLFFFFGARVRTFSRYAYTPETNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XW4</accession>
    <name>Q59XW4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ACS1</name>
        <name evidence="11" type="ordered locus">CAALFM_C210350CA</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714389.1">
        <property type="nucleotide sequence ID" value="XM_709296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XW4"/>
    <dbReference type="SMR" id="Q59XW4"/>
    <dbReference type="FunCoup" id="Q59XW4">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59XW4"/>
    <dbReference type="GeneID" id="3643941"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210350CA"/>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10350C_A"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="InParanoid" id="Q59XW4"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016880">
        <property type="term" value="F:acid-ammonia (or amide) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019654">
        <property type="term" value="P:acetate fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="104"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="553"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="675" mass="75140" checksum="3D54EC14B45F7EF7" modified="2005-04-26" version="1">MPESTQQSHLSLDHEKMQQPPKGFTERSKTKPNLPDFETYQKLYKQSIENPNEFFTQQAKENLDWFKPFDLARFPIDPKDDYKNGDLPAWFINGQLNACYNAVDRWAIKNPDKPAIIYEGDEPDQGRIITYGELLKQVSKLAQALTKLGVKKGDSVAVYLPMIPEAIVTLLAIVRIGAMHSVVFAGFSSASLRDRILDADSRIVITADESKRGGKTIETKKIVDDALKECPKVRNVIVFKRTGNSHVPFSPGRDLWWHDEMAKYGPYFPPVPVNSEDPLFLLYTSGSTGKPKGVQHNTAGYLLGAVLTTKYTFDVHEDDILFTAGDIGWITGHTYCVYGPLLAGATSVVFEGTPAYPNYSRYWEIVDKYKVNQFYVAPTALRLLKRAGTKYVEKYDLSSLRVLGSVGEPIAAEVWHWYNDNIGRGQAHIVDTYWQTESGSHLLTPLAGITPTKPGSASLPFFGVDPKILDPTTGEELPDNDVEGVLAIKSAWPSITRGIYNDYNRFIDTYLAPYANYYFSGDGAARDRDGFYWILGRVDDVVNVSGHRLSTAEIEAALIEHPIVGESAVVGYADELTGQAVAAYVSLKKDKAVGEDVENIKKEMILTVRKEIGPFAAPKMILLVDDLPKTRSGKIMRRILRKVLAGEEDQLGDISTLSNPGVVQQIIDVVHHAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Z50</accession>
    <name>Q59Z50_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">SPE3</name>
        <name evidence="7" type="ordered locus">CAALFM_C206960WA</name>
        <name evidence="6" type="ordered locus">orf19.9790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714840.1">
        <property type="nucleotide sequence ID" value="XM_709747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Z50"/>
    <dbReference type="SMR" id="Q59Z50"/>
    <dbReference type="FunCoup" id="Q59Z50">
        <property type="interactions" value="1048"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Z50"/>
    <dbReference type="GeneID" id="3643528"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206960WA"/>
    <dbReference type="CGD" id="CAL0000181339">
        <property type="gene designation" value="SPE3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06960W_A"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_1"/>
    <dbReference type="InParanoid" id="Q59Z50"/>
    <dbReference type="OMA" id="FLYHEMM"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000181339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="297" mass="33900" checksum="3818BA932586F688" modified="2005-04-26" version="1">MAQELTHPAIKDGWFAEISDTMWPGQAMSLKVEKVLHVEKSKYQDVLVFKSTTYGNVLVLDNCIQVTERDEFSYQEMITHLALNSHPNPKKALVIGGGDGGVLREILKHESIEEAWLCDIDETVIEVSKKYLPNMAKSYDDPRTRVHIGDGFKFLEEYKNQFDVIITDSSDPEGPAESLFQKPYFQLLKDALTEKGVITTQAENMWIHMDIISKLKKDCNEIFPVAEYAYTMIPTYPSGSIGFMVCSKDPNANVSKPIRFDWSDEFVAKNLKYYNKKIHEAAFVLPTWADQVLNKKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZW9</accession>
    <accession>A0A1D8PFW2</accession>
    <name>TIM16_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAM16</name>
        <name type="synonym">TIM16</name>
        <name type="ordered locus">CAALFM_C114150CA</name>
        <name type="ORF">CaO19.7222</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715023.1">
        <property type="nucleotide sequence ID" value="XM_709930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZW9"/>
    <dbReference type="SMR" id="Q59ZW9"/>
    <dbReference type="FunCoup" id="Q59ZW9">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZW9"/>
    <dbReference type="EnsemblFungi" id="C1_14150C_A-T">
        <property type="protein sequence ID" value="C1_14150C_A-T-p1"/>
        <property type="gene ID" value="C1_14150C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643321"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114150CA"/>
    <dbReference type="CGD" id="CAL0000176330">
        <property type="gene designation" value="PAM16"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14150C_A"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="InParanoid" id="Q59ZW9"/>
    <dbReference type="OMA" id="RMFKIND"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000214089" description="Mitochondrial import inner membrane translocase subunit TIM16">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="J-like">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="121" mass="13306" checksum="09757E9A43DD8E03" modified="2005-04-26" version="1">MAHRLLVNVIFTGASVFGRAFTEAYRQAAKASAAGAAGRPAKASSAGGIPVEEAMKILDLEKSELSLDKVEEKYEYLFNVNSKEQGNSFYLQSKVYYAMDTLKKELEYLEKLQNEKGAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0H8</accession>
    <name>Q5A0H8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ECS3</name>
        <name evidence="8" type="ordered locus">CAALFM_C202730WA</name>
        <name evidence="7" type="ordered locus">orf19.13255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715373.1">
        <property type="nucleotide sequence ID" value="XM_710280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0H8"/>
    <dbReference type="SMR" id="Q5A0H8"/>
    <dbReference type="FunCoup" id="Q5A0H8">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0H8"/>
    <dbReference type="GeneID" id="3643035"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202730WA"/>
    <dbReference type="CGD" id="CAL0000194981">
        <property type="gene designation" value="ECS3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02730W_A"/>
    <dbReference type="eggNOG" id="KOG1816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037790_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A0H8"/>
    <dbReference type="OMA" id="VCMIETD"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000194981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="363" mass="40455" checksum="C78BA196ADB497EF" modified="2005-04-26" version="1">MFSGFGSSIYGSGFGSSGFPSNKFEEYFRCYPIAMMPDLIRKDDANYGGKIFLPPSALNKLTMLHIRYPMLFEIKNEQNEKLTHSGVLEFIAEEGRTYLPQWMMNTLELTPGSLIKITNCDLNLGKFVKIEPQSVDFLDISDPKAVLENVLRKFSTLTVNDIIEVNYNDAIYGIRVLEVKPDSTSKGICVVETDLETDFAPLVGYVEPEYKPKTVEPSSKPIDPSKVNKSAGAATMAKSINYAKLVAEAGKTTKFSGSGQKLSGKSIDMDKNQSTKNYRIDDLDPDAPPVPLSLPENQLFFGFPVVLPTQEEIDEESKEELKKQQAFSGSGQSLRQSKKRKDKNTNYPSLKNHTRSPDAIEID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A319</accession>
    <accession>A0A1D8PTU8</accession>
    <name>NPR3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NPR3</name>
        <name type="synonym">RMD11</name>
        <name type="ordered locus">CAALFM_CR08680CA</name>
        <name type="ORF">CaO19.13802</name>
        <name type="ORF">CaO19.6444</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716281.1">
        <property type="nucleotide sequence ID" value="XM_711188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A319"/>
    <dbReference type="SMR" id="Q5A319"/>
    <dbReference type="FunCoup" id="Q5A319">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A319"/>
    <dbReference type="EnsemblFungi" id="CR_08680C_A-T">
        <property type="protein sequence ID" value="CR_08680C_A-T-p1"/>
        <property type="gene ID" value="CR_08680C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642127"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08680CA"/>
    <dbReference type="CGD" id="CAL0000182919">
        <property type="gene designation" value="orf19.13802"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08680C_A"/>
    <dbReference type="eggNOG" id="ENOG502QW35">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014314_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A319"/>
    <dbReference type="OMA" id="CNLAFRY"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="PRO" id="PR:Q5A319"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000301796" description="Nitrogen permease regulator 3">
        <location>
            <begin position="22"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="715" mass="81904" checksum="6F3319FD2FB1EBDA" modified="2005-04-26" version="1" precursor="true">MSLNLPNPSLIGILLVISTHSGPQLIYKYPFDLSNDPSRDESKYALDDNEDDELYDHEESEDENEVNENEMYGVNSRNWDSKHIDYYMGTKSDLLKFLDEQDSRRRKITTTSPSEEKHTKEKHGLTKTISKSSTMASSSTTSPPESSIQGEIFGTDAAYICEMLAPPKQMCNTRFEMTIQDKLFLGLPVHRSDNGQWRSIGHNNEHDEEETHTAKNSLNMFHLVFVMNPPVIESNYRVDEMFHYVISRLSLVLRYEQQKHDYVSQQVKNILALRESLEGNESLLTEKSSLSRVIRDCFEGISTSTIANLSINGKLRSFQIPIKTEFHSLPDPSVPFLPASYLSSTVELLGDTSFINVGETSRYGHAFNSVQDEENSAEKIIVYFALLLLDDPESIIKDMKTETDSTLAKFIRMIEPTESLLKLSARNSKLDISQIKDFAFHLIYWRRARVILPLSSRSVYIVSPMAPITIKLYDDISFFNRRFPTLPSLPHFLKLLSPQSRKPQQFATVIPSKDHRDRYLQALGWLIKHGYVTQLQTFIWLKISRKIKIKVEEDIENENLAKKKKKQKNGSVTVATANSSKTEAPIMPTDNTSKQVSDSKDSDKPEDDEYASKPRLDGLHEHIDGTPIVTLVQGDDTIILDPGRATTLERRWINKIIYEECKLSPELTAVFYKLLKYMNGKNSLELLLLKENISRSELRKLLLSIEEHIISVRHW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-05-27" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3P6</accession>
    <accession>A0A1D8PFF1</accession>
    <accession>Q5A3V9</accession>
    <name>PKH2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase PKH2</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PKB-activating kinase homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PKH2</name>
        <name evidence="6" type="synonym">PKH1</name>
        <name type="ordered locus">CAALFM_C112410CA</name>
        <name type="ORF">CaO19.12690</name>
        <name type="ORF">CaO19.5224</name>
        <name type="ORF">orf19.5224</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="MBio" volume="4" first="E00723" last="E00723">
            <title>The MARVEL domain protein Nce102 regulates actin organization and invasive growth of Candida albicans.</title>
            <authorList>
                <person name="Douglas L.M."/>
                <person name="Wang H.X."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="24281718"/>
            <dbReference type="DOI" id="10.1128/mBio.00723-13"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="ACS Chem. Biol." volume="8" first="2283" last="2292">
            <title>PIF-pocket as a target for C. albicans Pkh selective inhibitors.</title>
            <authorList>
                <person name="Pastor-Flores D."/>
                <person name="Schulze J.O."/>
                <person name="Bahi A."/>
                <person name="Giacometti R."/>
                <person name="Ferrer-Dalmau J."/>
                <person name="Passeron S."/>
                <person name="Engel M."/>
                <person name="Suss E."/>
                <person name="Casamayor A."/>
                <person name="Biondi R.M."/>
            </authorList>
            <dbReference type="PubMed" id="23911092"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.16 ANGSTROMS)</scope>
        <scope>DOMAIN</scope>
        <source>
            <strain>SC5314 / CAI4 / ATCC MYA-682</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <text evidence="2">Localizes at eisosomes, large, immobile complexes that mark sites of endocytosis near the plasma membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.</text>
    </comment>
    <comment type="disruption phenotype">
        <text>Sensitive to cell wall-damaging agents SDS and Congo red.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716293.2">
        <property type="nucleotide sequence ID" value="XM_711200.2"/>
    </dbReference>
    <dbReference type="PDB" id="4C0T">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.16 A"/>
        <property type="chains" value="A=1-944"/>
    </dbReference>
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    <keyword id="KW-0002">3D-structure</keyword>
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    <keyword id="KW-0418">Kinase</keyword>
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    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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    <sequence length="947" mass="106555" checksum="C8E682E4517872EA" modified="2017-03-15" version="2">MHKFRYSLHQHYSKRNSSDKSKDSPISQNSNEENDSTKLSSSSLQDLHDDLDDIYNNYTLAQGTNNNSVDTLDSENNQAINKFIDKPPAIHGMEPQLPVMHVSSRLSSLGNTTNETGESIAKSAPGTPLSSHSFDFRPHHPRAVTNSSLNVLLDTPNVSSEFNHLVDQTPPNESVERFDDSNNTVDNTEEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMMKVPELNKAPITTVIKKNVKKSTNSNSNTNNVATAVGGSSSNGHKGSSPTPEKEPSPATINNKSTEKVSAASVAAYVLNKPATNQNSSTSEDSSKRSSNSNETRKLSYSQQDYIPGTNILRPQISTRPSVGSYVKTTPSKDRKTLTKVPSNIHQQQEKVKPKVMEVKPATTLEAAWEPYLTHPDERILRIGPVIAHKEPTEPFEKKNKASLHISPLDINKEQRSRSNTSLLTQIVNEVNNNTSELKKVENADESLAIIEPQYNMKRSPTSDSKKSMDIERSASTSGSRISKKAIFKKLGFSHLEKNDSEESNGPSLTEKPQTCTLVVTTHGRALLFIRNDIESNYLLIAEIKLKYPFIHFQELVISQTKFSKLVPSVGVFVISSIDNSLIFEVEKFEVNQWTEALAKSKYNEIGKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2025-04-09" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4H4</accession>
    <accession>A0A1D8PKH7</accession>
    <name>SGF11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SGF11</name>
        <name type="ordered locus">CAALFM_C305790CA</name>
        <name type="ORF">CaO19.7360</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330875.1">
        <property type="nucleotide sequence ID" value="XM_019475330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4H4"/>
    <dbReference type="SMR" id="Q5A4H4"/>
    <dbReference type="STRING" id="237561.Q5A4H4"/>
    <dbReference type="EnsemblFungi" id="C3_05790C_A-T">
        <property type="protein sequence ID" value="C3_05790C_A-T-p1"/>
        <property type="gene ID" value="C3_05790C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641753"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305790CA"/>
    <dbReference type="CGD" id="CAL0000189519">
        <property type="gene designation" value="orf19.7360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05790C_A"/>
    <dbReference type="HOGENOM" id="CLU_130538_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A4H4"/>
    <dbReference type="OMA" id="RYFSCEN"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03047">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000367537" description="SAGA-associated factor 11">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SGF11-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="120" mass="13240" checksum="33F9140C7448E925" modified="2017-03-15" version="2">MTSTPITYKTLADSIFNDLINNIIKQHTLTSLTNIKDHSSLLNSSNSNTNSNTNGTIASNGGNGTTSDENNEIENSTIQDKSKLKQLETSRYFRCLNCGRNIAGGRFASHISKCLERKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4M7</accession>
    <name>Q5A4M7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">PTK2</name>
        <name evidence="13" type="ordered locus">CAALFM_C601710CA</name>
        <name evidence="12" type="ordered locus">orf19.10918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716724.1">
        <property type="nucleotide sequence ID" value="XM_711631.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4M7"/>
    <dbReference type="SMR" id="Q5A4M7"/>
    <dbReference type="FunCoup" id="Q5A4M7">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4M7"/>
    <dbReference type="GeneID" id="3641611"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601710CA"/>
    <dbReference type="CGD" id="CAL0000186778">
        <property type="gene designation" value="PTK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01710C_A"/>
    <dbReference type="HOGENOM" id="CLU_009275_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A4M7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000949">
        <property type="entry name" value="Serine/threonine-protein kinase PTK1/STK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="229"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="626"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="687"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000186778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW30108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="812" mass="89292" checksum="5D516600FC289AB1" modified="2005-04-26" version="1">MTKEHSIRNIFKKDKTPDNGSATATPSSSHTGLSKLFHKESKPITPPMKRTPSVSSLKRRNTNPSQTSGISLNHNHHHHQDSQNHNDATTSGGNIHSSTPVNRSRSNSDRSGHVPPTGRKVLSKAETFTHLQQLDTRNAAKNQLRNHRIPSNHLSSPLSAAPHSDKIVYNPYGLNKTATQERPKNTSFYLSGVNDGERVLSNPVASPNDYLPAELQQQHVNLLEDFEIDVGTKKLGDGGSSDVRIINSCHHKKDLYALKKFTLLSKETDEDFYKRVSEEYKIHRKAAISRHVVDAFAILRIQSQSNLTRGWGMVMEFCGGGDLFSVIVKPGWKSTPLAEKYCLFKQIAYGVKFLHDHDIVHRDLKPENVLLDANGLAKLCDFGVSEFGHEVPEDFSSPVKLSTAYVGSPPYAPPEVMLLKEKSSTEIKAFAYDPFKMDCWGLGMLLFCLVYGGVPFQQSSPNDHAFRDYKFSHKRFCTDHHTFKSNQGYPRGPGSEFKLAAKFENNGASRVAWKLCDPSENTRYTMDMLFDDPWFQSVEMCIYESPDQEVNPFVLPGTGENIDTHSVSGYSSVNNSQAPSRRGTFTSRPVGSGAGSGYNSHDESSNGLSSSFRSMLDLKDIPQKITKTDEPLPSNSSVHSNDSSSARAKSKLDHPSSPGSLLSPSTPALQSIPADRVAQTTSPINASLPAVEESDIEHESESEIQGDETESSGLQVLPPIDDVVAASPSSLTHEPQEQVLDSVESCISLPPNRDQAFAGKDGEMCSLVDLKPAALKSATDLQLGADGMCNLGYKIKKHHHTEVSNVSNSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4Z2</accession>
    <name>Q5A4Z2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Type I HSP40 co-chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C500350CA</name>
        <name evidence="9" type="ordered locus">orf19.8569</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
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            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1998" name="Microbiology" volume="144" first="2715" last="2729">
            <title>The two-component hybrid kinase regulator CaNIK1 of Candida albicans.</title>
            <authorList>
                <person name="Srikantha T."/>
                <person name="Tsai L."/>
                <person name="Enger L."/>
                <person name="Highley K."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="9802013"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1998" name="Proc. Natl. Acad. Sci. U.S.A." volume="95" first="7069" last="7073">
            <title>COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans.</title>
            <authorList>
                <person name="Alex L.A."/>
                <person name="Korch C."/>
                <person name="Selitrennikoff C.P."/>
                <person name="Simon M.I."/>
            </authorList>
            <dbReference type="PubMed" id="9618540"/>
            <dbReference type="DOI" id="10.1073/pnas.95.12.7069"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="7243" last="7247">
            <title>Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans.</title>
            <authorList>
                <person name="Yamada-Okabe T."/>
                <person name="Mio T."/>
                <person name="Ono N."/>
                <person name="Kashima Y."/>
                <person name="Matsui M."/>
                <person name="Arisawa M."/>
                <person name="Yamada-Okabe H."/>
            </authorList>
            <dbReference type="PubMed" id="10572127"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>AUTOPHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="Med. Mycol." volume="39" first="69" last="74">
            <title>COS-l, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor.</title>
            <authorList>
                <person name="Selitrennikoff C.P."/>
                <person name="Alex L."/>
                <person name="Miller T.K."/>
                <person name="Clemons K.V."/>
                <person name="Simon M.I."/>
                <person name="Stevens D.A."/>
            </authorList>
            <dbReference type="PubMed" id="11270409"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="BMC Microbiol." volume="13" first="209" last="209">
            <title>Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants.</title>
            <authorList>
                <person name="El-Mowafy M."/>
                <person name="Bahgat M.M."/>
                <person name="Bilitewski U."/>
            </authorList>
            <dbReference type="PubMed" id="24044701"/>
            <dbReference type="DOI" id="10.1186/1471-2180-13-209"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="4" first="409" last="416">
            <title>The histidine kinases of Candida albicans: regulation of cell wall mannan biosynthesis.</title>
            <authorList>
                <person name="Kruppa M."/>
                <person name="Jabra-Rizk M.A."/>
                <person name="Meiller T.F."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="14734021"/>
            <dbReference type="DOI" id="10.1016/S1567-1356(03)00201-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2012" name="J. Biotechnol." volume="157" first="268" last="277">
            <title>A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity.</title>
            <authorList>
                <person name="Buschart A."/>
                <person name="Gremmer K."/>
                <person name="El-Mowafy M."/>
                <person name="van den Heuvel J."/>
                <person name="Mueller P.P."/>
                <person name="Bilitewski U."/>
            </authorList>
            <dbReference type="PubMed" id="21963586"/>
            <dbReference type="DOI" id="10.1016/j.jbiotec.2011.09.017"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 8 9 10 11">Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Required for hyphal formation and virulence. Plays a role in fungicides sensitivity, probably through the positive regulation of the HOG1-signaling pathway. Presumed to mediate phosphotransfer to the HOG1 MAP kinase pathway during oxidative and perhaps osmotic stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="12">Expression is increased in opaque cells.</text>
    </comment>
    <comment type="domain">
        <text evidence="9 10">The HAMP domains are critical for the sensitivity to fungicides such as fludioxonil, as well as for activation of HOG1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The phosphorelay mechanism involves the sequential transfer of a phosphate group from His-510 (H1) in the histidine kinase domain (transmitter domain) to Asp-924 (D1) of the response regulatory domain (receiver domain). This transfer probably occurs between two NIK1 molecules, rather than intramolecularly.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6 7 8 11 12">Impairs the hyphal formation and attenuates the virulence in a mouse systemic candidiasis model.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3"/>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717003.2">
        <property type="nucleotide sequence ID" value="XM_711910.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A599"/>
    <dbReference type="SMR" id="Q5A599"/>
    <dbReference type="STRING" id="237561.Q5A599"/>
    <dbReference type="EnsemblFungi" id="C7_02800W_A-T">
        <property type="protein sequence ID" value="C7_02800W_A-T-p1"/>
        <property type="gene ID" value="C7_02800W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641358"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702800WA"/>
    <dbReference type="CGD" id="CAL0000187540">
        <property type="gene designation" value="NIK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02800W_A"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_1_1"/>
    <dbReference type="InParanoid" id="Q5A599"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000425799" description="Histidine protein kinase NIK1">
        <location>
            <begin position="1"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP 1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP 2" evidence="2">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP 3" evidence="2">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP 4" evidence="2">
        <location>
            <begin position="341"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP 5" evidence="2">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="507"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="875"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="3">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="924"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAE44787." evidence="13" ref="1">
        <original>S</original>
        <variation>T</variation>
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="10572127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="11270409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="14734021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="21963586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="24044701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="9618540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="9802013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <sequence length="1081" mass="118932" checksum="260EE960E55CACF3" modified="2017-03-15" version="3">MNPTKKPRLSPMQPSVFEILNDPELYSQHCHSLRETLLDHFNHQATLIDTYEHELEKSKNANKAFQQALSEIGTVVISVAMGDLSKKVEIHTVENDPEILKVKITINTMMDQLQTFANEVTKVATEVANGELGGQAKNDGSVGIWRSLTDNVNIMALNLTNQVREIADVTRAVAKGDLSRKINVHAQGEILQLQRTINTMVDQLRTFAFEVSKVARDVGVLGILGGQALIENVEGIWEELTDNVNAMALNLTTQVRNIANVTTAVAKGDLSKKVTADCKGEILDLKLTINQMVDRLQNFALAVTTLSREVGTLGILGGQANVQDVEGAWKQVTENVNLMATNLTNQVRSIATVTTAVAHGDLSQKIDVHAQGEILQLKNTINKMVDSLQLFASEVSKVAQDVGINGKLGIQAQVSDVDGLWKEITSNVNTMASNLTSQVRAFAQITAAATDGDFTRFITVEASGEMDALKTKINQMVFNLRESLQRNTAAREAAELANSAKSEFLANMSHEIRTPLNGIIGMTQLSLDTELTQYQREMLSIVHNLANSLLTIIDDILDISKIEANRMTVEQIDFSLRGTVFGALKTLAVKAIEKNLDLTYQCDSSFPDNLIGDSFRLRQVILNLAGNAIKFTKEGKVSVSVKKSDKMVLDSKLLLEVCVSDTGIGIEKDKLGLIFDTFCQADGSTTRKFGGTGLGLSISKQLIHLMGGEIWVTSEYGSGSNFYFTVCVSPSNIRYTRQTEQLLPFSSHYVLFVSTEHTQEELDVLRDGIIELGLIPIIVRNIEDATLTEPVKYDIIMIDSIEIAKKLRLLSEVKYIPLVLVHHSIPQLNMRVCIDLGISSYANTPCSITDLASAIIPALESRSISQNSDESVRYKILLAEDNLVNQKLAVRILEKQGHSVEVVENGLEAYEAIKRNKYDVVLMDVQMPVMGGFEATEKIRQWEKKSNPIDSLTFRTPIIALTAHAMLGDREKSLAKGMDDYVSKPLKPKLLMQTINKCIHNINQLKELSRNSRGSDFAKKMTRNTPGSTTRQGSDEGSVEDMIGDTPRQGSVEGGGTSSRPVQRRSATEGSITTISEQIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5Q8</accession>
    <name>Q5A5Q8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">RPS4A</name>
        <name evidence="11" type="ordered locus">CAALFM_C210620WA</name>
        <name evidence="10" type="ordered locus">orf19.12801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717144.1">
        <property type="nucleotide sequence ID" value="XM_712051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5Q8"/>
    <dbReference type="SMR" id="Q5A5Q8"/>
    <dbReference type="FunCoup" id="Q5A5Q8">
        <property type="interactions" value="1293"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A5Q8"/>
    <dbReference type="GeneID" id="3641247"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210620WA"/>
    <dbReference type="CGD" id="CAL0000195247">
        <property type="gene designation" value="RPS4A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10620W_A"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A5Q8"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="PHI-base" id="PHI:6076"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000195247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="262" mass="29364" checksum="66E2C9A11692BF9B" modified="2005-04-26" version="1">MGRGPKKHLKRLAAPSHWMLDKLSGTYAPRPSAGPHKLRESLPLVVFLRNRLKYALNGREVKAIMMQQHVQVDGKVRTDTTYPAGFMDVITLEATNEHFRLVYDVKGKFAVHRISAEEAAYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPLIRANDTVKIDLATGKIDDFIKFDTGRLVMVTGGRNLGRVGVIVHREKHEGGFDLVHIKDALENTFVTRLSNVFVIGTEAGKPWVSLPKGKGIKLSISEERDRRRAQQGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6T5</accession>
    <accession>A0A1D8PSL2</accession>
    <name>STE7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase STE7 homolog</fullName>
            <ecNumber>2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HST7</name>
        <name type="synonym">STE7</name>
        <name type="ordered locus">CAALFM_CR03900WA</name>
        <name type="ORF">CaO19.469</name>
        <name type="ORF">CaO19.8100</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717333.2">
        <property type="nucleotide sequence ID" value="XM_712240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6T5"/>
    <dbReference type="SMR" id="Q5A6T5"/>
    <dbReference type="BioGRID" id="1223967">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A6T5">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6T5"/>
    <dbReference type="EnsemblFungi" id="CR_03900W_A-T">
        <property type="protein sequence ID" value="CR_03900W_A-T-p1"/>
        <property type="gene ID" value="CR_03900W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640953"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03900WA"/>
    <dbReference type="CGD" id="CAL0000197730">
        <property type="gene designation" value="HST7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03900W_A"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q5A6T5"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="PRO" id="PR:Q5A6T5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990277">
        <property type="term" value="P:parasexual reproduction with cellular fusion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071507">
        <property type="term" value="P:pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001756">
        <property type="entry name" value="Serine/threonine-protein kinase STE7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001022">
        <property type="entry name" value="Serine/threonine-protein kinase STE7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000413042" description="Serine/threonine-protein kinase STE7 homolog">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="255"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="589" mass="65224" checksum="6C1209F89BD7A8F5" modified="2017-04-12" version="2">MTRTTRIDTQEATKHKDLPPVPSPLSLSSNPNPECLMESKSLGRKNFKKLSLDASPVKSTSGSLRSSDMMSIKEPTSLRQKRQRPPPILHLPTASSSATSTPTSNITGSSSASSIQFAQKSPGSGVIVSQTLSRPSSAGGIPSSGYSSLNVNQSNRNVDPDNVVSTDMILNQISNLDLTSMNHHRQHYQNSHHHLPTTNRKRQTVISSISPTKSSAASSSLEPQIQSLPASSQSPIATTSSLKLNNKDLLTLKQLGSGNSGSVSKILHIPTQKTMAKKIIHIDSKSVIQTQIIRELRILHECHSPYIIEFYGACLNNNNTIVICMEYCNCGSLDKILPLCENKQFPTFVLKKLSFAILSGLTYLYTTHKIIHRDIKPNNVLMTHKGEFKLCDFGVSRELTNSLAMADTFVGTSMYMSPERIQGLDYGVKSDVWSTGLMLIELASGVPVWSEDDNNNDDDEDDEDDAYVRQGSIAAERNGQNSPSRSRKNKQKGNGYNSYNGPEGILDLLQRIVNEDAPTLTNKINPVTKLPYDKYLCQFIDLCLIKDDSVRKTPWQLLEDKEHFFKGVEEGVYDKEHKSWAKKIRKCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A850</accession>
    <name>Q5A850_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">GSY1</name>
        <name evidence="10" type="ordered locus">CAALFM_CR00780CA</name>
        <name evidence="9" type="ordered locus">orf19.10788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717968.1">
        <property type="nucleotide sequence ID" value="XM_712875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A850"/>
    <dbReference type="SMR" id="Q5A850"/>
    <dbReference type="FunCoup" id="Q5A850">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A850"/>
    <dbReference type="GeneID" id="3640435"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00780CA"/>
    <dbReference type="CGD" id="CAL0000199911">
        <property type="gene designation" value="GSY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00780C_A"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A850"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000199911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="661" mass="75580" checksum="6D892588E976CC90" modified="2005-04-26" version="1">MARDIDNHLLFEVATEVAHKVGGIYSVLKSKAPVTVAEYRERYTLLGPLHYDSAQIEVEELPVTDPHIKQTLDSMSSKGIRWLYGRWLIEGAPRVLLFDIWSAGHYLNEWKADLWNVAGIPTPDHDSETNDAILLGYLVAWFLGELVYNDRDRAVICQCHEWLAGIALPLCRKRRIDVTTIFTTHATLLGRYLCAGSTDFYNNLDKFDVDAEAGKRGIYHRYCIERSATHSADVFTTVSDITAYEAEHLLKRKPDGVLPNGLNVVKFQAVHEFQNLHAIKKAKINEFVKGHFYGNYDFDLDNTLYFFIAGRYEFRNKGCDFFIESLARLNHKLKEAGSKTTVVAFIIMPGKTQSYTVETLKGQAVVKQLESTIGEVQKKVGERLFEYCARYPNTDHHGNDEVPTIDELIKPADRVLLKRRIFALKRDGLPPIVTHNMVDDSTDPVLNHIRRVQLFNKPEDRVKIIFHPEFLNANNPILSLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSITTNLSGFGCYMNDLVENPTDYGIYIVDRRMKSVDESINQLTDYMFDFCAKSRRQRINQRNRTERLSVLLDWRSVHSEYSKARLLALKRAYPDYVGEKVVESKMKITRPMSVPGSPRSLLLTPGDLGSLQDANQDISYFELGEEET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8I6</accession>
    <accession>A0A1D8PQA1</accession>
    <name>PGA61_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell wall protein PGA61</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Predicted GPI-anchored protein 61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PGA61</name>
        <name type="ordered locus">CAALFM_C603860CA</name>
        <name type="ORF">CaO19.13185</name>
        <name type="ORF">CaO19.5762</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <topology evidence="4">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718097.2">
        <property type="nucleotide sequence ID" value="XM_713004.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8I6"/>
    <dbReference type="STRING" id="237561.Q5A8I6"/>
    <dbReference type="GlyCosmos" id="Q5A8I6">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_03860C_A-T">
        <property type="protein sequence ID" value="C6_03860C_A-T-p1"/>
        <property type="gene ID" value="C6_03860C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640292"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603860CA"/>
    <dbReference type="CGD" id="CAL0000195894">
        <property type="gene designation" value="PGA61"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03860C_A"/>
    <dbReference type="HOGENOM" id="CLU_1102657_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A8I6"/>
    <dbReference type="OrthoDB" id="4017894at2759"/>
    <dbReference type="PRO" id="PR:Q5A8I6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424745" description="Probable cell wall protein PGA61">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424746" description="Removed in mature form" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated asparagine" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="223" mass="23182" checksum="B742D2A11AC9FDC2" modified="2017-04-12" version="2" precursor="true">MKSGLLLAVILPVAFAVKKDQQSCNSSCVKVLQKQQESCPSGSDADCLCKLSDSDYWEPLTDCDCINPDKKLSASEIKVQICGAPSSSSTPTSSTETTSSTEAETTEAETTEQPSSSTSSNTESSKTTILETPSIQELNAESTTSVITPLTESAVAAVANTDTSTLIEPQNTEATPEVAPLIQPQLNNGSDLAQVSVQAFENGAGRAAVIGSGSLLALLLNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A928</accession>
    <name>Q5A928_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C101180CA</name>
        <name evidence="8" type="ordered locus">orf19.10816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718129.1">
        <property type="nucleotide sequence ID" value="XM_713036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A928"/>
    <dbReference type="SMR" id="Q5A928"/>
    <dbReference type="FunCoup" id="Q5A928">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A928"/>
    <dbReference type="GeneID" id="3640206"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101180CA"/>
    <dbReference type="CGD" id="CAL0000183053">
        <property type="gene designation" value="orf19.10816"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01180C_A"/>
    <dbReference type="eggNOG" id="KOG4652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449757_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A928"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016573">
        <property type="entry name" value="Hop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010751">
        <property type="entry name" value="HOP1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000183053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="607" mass="69399" checksum="5E4079B966C3AB3E" modified="2005-04-26" version="1">MMVGQAELTRESHKSIQELIAVSLYCISYLRDLFPENHYSDYKYYDTTEPTSDSNFILTKKLQGNDNAEINMFINYIEKGINDAIKLEYLKGVSFEIFLSKEHPQLICESYLFTINYSRQEVSINDETSFRATKTTIIQSIQGIVKRLILLTQTFDRLPDEKYFAIRLLFNESCPVRYQPPYFQDATYAKPSSITVNQGYIGLEISQMNAYNNCVKMNILVETCKLENCHSIDPFDLVDKQIDQFEAVPSCNIDLDEYLDDPNMTEVQSQKQKTNTFEVTNCRKCNISIYSVAYGYNKPIKNSITCFKCLLKNKFDNDLSILMSIRLLWHFFMMNEFPSFEKSLELIHLVHTGSVVHVFNKMFSDKILVVTNKAMFGPNSVDFISGSGSFIPTVEGIIANDGKQLQKHSEYFVSFVPRMCTIPSFFAYNKKLDSVYFPNYLVQRADFVLSNLQKFKAGSFGKRIVGSSSSSSLQVTKPNSKSGAICKLKSGGRGRGRPSLVSSSFKPSLHPSGSIYSQSNSIIESTNDMTPLQLKEESSPTTVVECSTQNISETLDDLSFEESLQYLSQSSELQIVKCKQQQQQEQQYYPPNFYQKKKNRARKQTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A9Z4</accession>
    <name>Q5A9Z4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ste3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">STE3</name>
        <name evidence="12" type="ordered locus">CAALFM_C105620CA</name>
        <name evidence="11" type="ordered locus">orf19.10028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718511.1">
        <property type="nucleotide sequence ID" value="XM_713418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A9Z4"/>
    <dbReference type="FunCoup" id="Q5A9Z4">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A9Z4"/>
    <dbReference type="GeneID" id="3639841"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105620CA"/>
    <dbReference type="CGD" id="CAL0000190867">
        <property type="gene designation" value="STE3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05620C_A"/>
    <dbReference type="eggNOG" id="ENOG502S44N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027592_4_0_1"/>
    <dbReference type="InParanoid" id="Q5A9Z4"/>
    <dbReference type="OMA" id="IPPLIWH"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000190867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="417" mass="47988" checksum="2B0FC5138A7089E0" modified="2005-04-26" version="1">MYKGAAGMGSFLIISFCLLIPPFLWHIRSRNLPATILIFWLMYVDLTGFISTMIWSGDNFDEAWDGQVYCDIVGKLDAGSSVGKCCAIACVIMNLYFVLCAKHPTLLEQGSWKKFAMDMAICLINPIFVMAVHYIVTGSRYAIVKYQGCSTIYSATYASLLLVSIWTVLWSIVALIFAVLTLITFFRKRKDVKDILLCTNSGLNIKRFARLLIFSFLIVFAMVPLSLYYFVSQAEVSKNPFHWDQVHNEEWNVIYFYDFGFFTFYDRLVNCILSVLAFIIFGLGSDALDMYKSMFHKVHNRFWYKKTDEPYSQEQAIKSMEPQTKINSNKSQFSNTTSFTNTSTMRDIENQFGDVMHQIISEENTSFRFEKQLQSSPATLVKEDGVPRELQSIIKDTDSSSDQIFYKYQVKSKSYDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2025-04-09" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADQ7</accession>
    <accession>A0A1D8PKP5</accession>
    <name>PGA32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable GPI-anchored adhesin-like protein PGA32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Predicted GPI-anchored protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PGA32</name>
        <name type="ordered locus">CAALFM_C307160WA</name>
        <name type="ORF">CaO19.14076</name>
        <name type="ORF">CaO19.6784</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="BMC Genomics" volume="12" first="192" last="192">
            <title>FungalRV: adhesin prediction and immunoinformatics portal for human fungal pathogens.</title>
            <authorList>
                <person name="Chaudhuri R."/>
                <person name="Ansari F.A."/>
                <person name="Raghunandanan M.V."/>
                <person name="Ramachandran S."/>
            </authorList>
            <dbReference type="PubMed" id="21496229"/>
            <dbReference type="DOI" id="10.1186/1471-2164-12-192"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="1451" last="1469">
            <title>Regulatory networks affected by iron availability in Candida albicans.</title>
            <authorList>
                <person name="Lan C.Y."/>
                <person name="Rodarte G."/>
                <person name="Murillo L.A."/>
                <person name="Jones T."/>
                <person name="Davis R.W."/>
                <person name="Dungan J."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="15387822"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04214.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Putative adhesin which is involved in cell adhesion and virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <topology evidence="6">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Induced upon high iron conditions.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719880.1">
        <property type="nucleotide sequence ID" value="XM_714787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADQ7"/>
    <dbReference type="STRING" id="237561.Q5ADQ7"/>
    <dbReference type="EnsemblFungi" id="C3_07160W_A-T">
        <property type="protein sequence ID" value="C3_07160W_A-T-p1"/>
        <property type="gene ID" value="C3_07160W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638537"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307160WA"/>
    <dbReference type="CGD" id="CAL0000193137">
        <property type="gene designation" value="PGA32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07160W_A"/>
    <dbReference type="HOGENOM" id="CLU_591823_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADQ7"/>
    <dbReference type="OMA" id="TTENTFW"/>
    <dbReference type="OrthoDB" id="4025024at2759"/>
    <dbReference type="PRO" id="PR:Q5ADQ7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424933" description="Probable GPI-anchored adhesin-like protein PGA32">
        <location>
            <begin position="17"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424934" description="Removed in mature form" evidence="2">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="2">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15387822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21496229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="430" mass="43529" checksum="0FE7A39C94AD8A85" modified="2005-04-26" version="1" precursor="true">MKVSTLIIVSIPIVSGLQIKDTVGTTTENTFWYQLFGTPSRSQPAAVAATAAGTEVQGFTPISTSSSSSSSSAAPWYQGLFGVGRTTLGQVTTPSRTSTTTTTSNPIAPTTSIANSNNLFGTDTAPTTTTTTNARSRSRSTPVTVSGDNVLTLFGNPNLSTGNDQSNSVSKTTAETTTTSSAPSSSSRVQPTVINGGGSDGVLTLFGNSEALSNFDSTTVVDSDSTARITPIASASASSGSSTKDNDSDSSSARGIKSIPNSSEFLASLINGLGSGGGGNGSGSNTNSYKNHSTTSTTSKYFNSSSTATKLSSSKSIYSNSTTSRSSLSVSSSSTDGGGGANLFGSLLNSVAAVSRTLAAESTLSTGTTTTSDSANSNTKDYSSYSGTITSFPSTTGSLSGDGNKLIGGNKYLISFMWTNLILTMIMLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADQ8</accession>
    <name>Q5ADQ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C307170CA</name>
        <name evidence="5" type="ordered locus">orf19.14075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719879.1">
        <property type="nucleotide sequence ID" value="XM_714786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADQ8"/>
    <dbReference type="SMR" id="Q5ADQ8"/>
    <dbReference type="FunCoup" id="Q5ADQ8">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADQ8"/>
    <dbReference type="GeneID" id="3638536"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307170CA"/>
    <dbReference type="CGD" id="CAL0000176006">
        <property type="gene designation" value="orf19.14075"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07170C_A"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_3_1_1"/>
    <dbReference type="InParanoid" id="Q5ADQ8"/>
    <dbReference type="OMA" id="HQYLEFQ"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000003">
        <property type="entry name" value="Rab proteins geranylgeranyltransferase component A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00894">
        <property type="entry name" value="YEASTMRS6P"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00060123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000176006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="670" mass="75850" checksum="97061724BF435BC1" modified="2005-04-26" version="1">MNFARTERRKSMAERRPSTVYTPPVIPHLAGLEKPQDQYLKMDNCDVLIIGTGLQESILAAALSWQGTQVLHIDSNTYYGDSCSTLTIEQLKKWCGDVNSGKIHQFQDAQIYIPGGKQSNQYTSKDYGIDLTPKIMFCQSDLLSLLIKSRVYRYLEFQSLSNFHVFENDDFQQKVNATTKQDIFTDKSLSLMTKRYLMKFLKFLLLDPDYKQRVKPYADTPIQVFLQQEFKLEEPQINELVYSIGLSYKEQTSTKQALIRMKRFLSSFDVYGKFPCMVSKFGGPGELSQGFCRSAAVAGTTYKLNTNLTDFDPISKIAHFNDGSHIKINEKIIISPTQLPKFLQSSYNKVVENLQPYYVTRLVTVVRRDCKEWMSGNESSAIVVFPPHSLPTDNQHSVQVIIQNGNSGVCPDGQAIWFSSTVEQDLSRAKVDLESAFEKMETSLLRESSEEIVNDILGDNNNNNNNDFVMNAQGTTTPVLVNSFKLGSSLINFVPKDKLEIVCKLGYVEKTFINPDLSNIFKPTKTNNIVYKDVEDANNEIIFTNMPSSELSYDGIITDVKSIYQRITGTTDDFFDVDFEDEEDEYDRNNQPVVQPKRSSVVGGIVGGGSITSLTALREQHNENNHSDNAIDSDEDEDEDINDMNDMNDNEEEDDHGRGPEPFGADEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI07</accession>
    <name>Q5AI07_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C103440CA</name>
        <name evidence="5" type="ordered locus">orf19.10563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721543.1">
        <property type="nucleotide sequence ID" value="XM_716450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI07"/>
    <dbReference type="SMR" id="Q5AI07"/>
    <dbReference type="STRING" id="237561.Q5AI07"/>
    <dbReference type="GeneID" id="3636908"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103440CA"/>
    <dbReference type="CGD" id="CAL0000201739">
        <property type="gene designation" value="orf19.10563"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03440C_A"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AI07"/>
    <dbReference type="OMA" id="SERCPHT"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000201739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="478" mass="52200" checksum="125B40C1B080FD50" modified="2005-04-26" version="1">MASTTIPSIIAGQDVFDTDLIHPVYSHEDTNEVIHTFSYIQVSPDIINQLAENSKSGFKEWSNTPVSKKKEIFYKCLEILREKKNEFIDTHKEIGGPDWFANVNIDGAIAQLEEYIGNLSNSEGELFHSDHNQLALTVRSPIGPVLSIAPWNAPVILGARSIFAPLAAGCSVIAKSPEKAPRAMYLLVKYLIEAGVPANVLQLVHLKPEDNPKFLDALLATGAIKKINFTGSTLIGKKIASTAAKYLVPCLLELGGKNVSIVCQDADITKAVGNIIWSAWTHKGQICMSTDRVFIHDTIYNDFKSKLIKVASEMVQDPDYSIAHRDPLGANKVKELLNDALQKGASLVFGNPDDSELKRNNVVSPMILEGVTPEMKLNDTESFGPIFAIEKFTDVNNVVDVVNESDFGLKASIWSSNLMNAIDLAKRIECGGVHINNSSIGDESHLPHGGVKASGSGRFNSKWGIDEFSFIKTITANP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK42</accession>
    <accession>A0A1D8PP46</accession>
    <name>EFG1P_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>rRNA-processing protein EFG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C504910WA</name>
        <name type="ORF">CaO19.11461</name>
        <name type="ORF">CaO19.3978</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721887.1">
        <property type="nucleotide sequence ID" value="XM_716794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK42"/>
    <dbReference type="SMR" id="Q5AK42"/>
    <dbReference type="FunCoup" id="Q5AK42">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK42"/>
    <dbReference type="EnsemblFungi" id="C5_04910W_A-T">
        <property type="protein sequence ID" value="C5_04910W_A-T-p1"/>
        <property type="gene ID" value="C5_04910W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636417"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504910WA"/>
    <dbReference type="CGD" id="CAL0000198404">
        <property type="gene designation" value="orf19.11461"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04910W_A"/>
    <dbReference type="eggNOG" id="KOG4484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066912_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AK42"/>
    <dbReference type="OMA" id="KPHRIQE"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="PRO" id="PR:Q5AK42"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000330265" description="rRNA-processing protein EFG1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="237" mass="27761" checksum="603037859D91C102" modified="2005-04-26" version="1">MPKTVKNPKNNKSRSRGAPIQVAESIGSGSAKIKKKIRDIERLIKKNPNLPADKKIEYDRALKGLKVELQNSQVQNKAKVLAKKYHMVRFFERKKAVRKLKNLRKEFERISQTGIRKDIKKARKQLRHGEIDLAYVILFPKTEKYISLYPSPNDEDQTDPNVIKGLKITEERRREFRKYIEKLMEEGKLPFSIDDALQGKNIRLDNDKTQKAVLTEEIDAPEQKQDEQQEEQDDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK60</accession>
    <name>Q5AK60_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">HYS2</name>
        <name evidence="13" type="ordered locus">CAALFM_C504740CA</name>
        <name evidence="12" type="ordered locus">orf19.11442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721869.1">
        <property type="nucleotide sequence ID" value="XM_716776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK60"/>
    <dbReference type="SMR" id="Q5AK60"/>
    <dbReference type="FunCoup" id="Q5AK60">
        <property type="interactions" value="931"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK60"/>
    <dbReference type="GeneID" id="3636441"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504740CA"/>
    <dbReference type="CGD" id="CAL0000186510">
        <property type="gene designation" value="HYS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04740C_A"/>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AK60"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006278">
        <property type="term" value="P:RNA-templated DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000005">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="203"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000186510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="474" mass="53843" checksum="45176B2A720EF18E" modified="2005-04-26" version="1">MSSSQFYNKGVDESVVSRQEIEEFTKRNEFFLKPSSRKYAKQYFSMYQYRLKNLRDRVHKTAMEKWGHGTKKINGNTIEKQDKILDIASGKLCWVIGTVFCDAKYKLDILNDVEKGTDDVLPLEPVTYVNEDEQPIVMLEDESGRAILNNDNFLAKNLLVTGCIVAVLGIEIQAGIFEIMDIAYPDCAPQKPLPLGENKRGKIALVSGLNIGDEGHYDLKLELLKQYLLGELGNAEDKLDGSLISQLIIAGDSIMPIQNLRAEMDLKNFVTTNNYGSKNISKYNVESFKKLDEFLTDILVSLPVAVMPGKNDPAEICLPQQPLHRSLFKNNSSLLDGNRLTRLTNPQWIDAQTVKILGTSGQNVDDIQKYIVPKKDHQFTSIEIMENNIKWQNFVPTAPDTLYCYPYENYDPFIFSDDLPHVYFVGNQQQFDSKLFEHDGVNVRLISIPKFKESGQFVLLDLDTLETEVVTIEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKB1</accession>
    <accession>A0A1D8PNX5</accession>
    <name>RNY1B_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Ribonuclease T2-like 1-B</fullName>
            <shortName>RNase T2-like B</shortName>
            <ecNumber>4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RNY1-B</name>
        <name type="ordered locus">CAALFM_C504260WA</name>
        <name type="ORF">CaO19.11391</name>
        <name type="ORF">CaO19.3910</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68052"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="4.6.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Vacuole lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Is released from the vacuole to the cytoplasm during stress conditions like oxidative stress or stationary phase stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721820.1">
        <property type="nucleotide sequence ID" value="XM_716727.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKB1"/>
    <dbReference type="SMR" id="Q5AKB1"/>
    <dbReference type="FunCoup" id="Q5AKB1">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AKB1">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C5_04260W_A-T">
        <property type="protein sequence ID" value="C5_04260W_A-T-p1"/>
        <property type="gene ID" value="C5_04260W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636451"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504260WA"/>
    <dbReference type="CGD" id="CAL0000201046">
        <property type="gene designation" value="orf19.11391"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04260W_A"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AKB1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="PRO" id="PR:Q5AKB1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043252" description="Ribonuclease T2-like 1-B">
        <location>
            <begin position="19"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="413" mass="45726" checksum="05DAC88BDFBD1FDA" modified="2005-04-26" version="1" precursor="true">MKYSILAILAHLLTNIKATQEVFTLSDLPPDSCPIDSPISCSKNAQELENVNSCCYESPAGVILLTQFWDYNPATGPDNLFTQHGLWGNMCSYGYPQFCDPSLEINPNGEIIRSIIVDQFGDEELYNNMSYSWKDYHGKDSSFWAHEYNKHGTCFSTIKPSCYLSNTPKNQNLYDFFRIAIGLFNKLPTYDWLAEAGIVPTNSKTYSLSEIQSALNDKFGANVFIKCDYNHAINEIWYYHHVKGSLLQHNFLPIDSVAHTNCPSTGIKYPPKGKVAHPTLTTKTTTGTSTTIHNPTGIPARSYVHLSGKSGCLISNGKWYTSGTCATYHFKKTIDDSNIEIRSSKGICGINGNEEFTCSRAVSGGTDFQIKDGKIGYQDKFDWCFGSTTGSGSTAQTSVKLADGSCDSFQLLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-02-04" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKU3</accession>
    <accession>A0A1D8PFT7</accession>
    <name>YBP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP1-binding-protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">YBP1</name>
        <name type="ordered locus">CAALFM_C113960WA</name>
        <name type="ORF">CaO19.12501</name>
        <name type="ORF">CaO19.5034</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="Antioxid. Redox Signal." volume="19" first="2244" last="2260">
            <title>Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.</title>
            <authorList>
                <person name="Patterson M.J."/>
                <person name="McKenzie C.G."/>
                <person name="Smith D.A."/>
                <person name="da Silva Dantas A."/>
                <person name="Sherston S."/>
                <person name="Veal E.A."/>
                <person name="Morgan B.A."/>
                <person name="MacCallum D.M."/>
                <person name="Erwig L.P."/>
                <person name="Quinn J."/>
            </authorList>
            <dbReference type="PubMed" id="23706023"/>
            <dbReference type="DOI" id="10.1089/ars.2013.5199"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH CAP1</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of CAP1. Functions probably in concert with GPX3, the actual CAP1 modifying enzyme.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with CAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1">Leads to decreased virulence in a Galleria mellonella model.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722236.2">
        <property type="nucleotide sequence ID" value="XM_717143.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKU3"/>
    <dbReference type="FunCoup" id="Q5AKU3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AKU3"/>
    <dbReference type="EnsemblFungi" id="C1_13960W_A-T">
        <property type="protein sequence ID" value="C1_13960W_A-T-p1"/>
        <property type="gene ID" value="C1_13960W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636187"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113960WA"/>
    <dbReference type="CGD" id="CAL0000191408">
        <property type="gene designation" value="YBP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13960W_A"/>
    <dbReference type="eggNOG" id="ENOG502RY9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024514_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AKU3"/>
    <dbReference type="OMA" id="TYEIGWD"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="PHI-base" id="PHI:3806"/>
    <dbReference type="PRO" id="PR:Q5AKU3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0034599">
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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    <dbReference type="GO" id="GO:0030682">
        <property type="term" value="P:symbiont-mediated perturbation of host defenses"/>
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        <property type="project" value="UniProtKB"/>
    </dbReference>
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        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
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        <property type="entry name" value="YBP1/2"/>
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        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
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    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000431936" description="CAP1-binding-protein">
        <location>
            <begin position="1"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="23706023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23706023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="643" mass="73954" checksum="7EC5151E65E38243" modified="2017-05-10" version="2">MENLESGAQDALQSKDFLSYSTLLDIYLNDPTKYSNEEKEQLLGHILTILSENKQLTYEIGWDLPQLLILYVDSDYEFNGPIRDSPGVYKILKIFENLAINGNHKELFLKSCELLNDLELSQDEDIELLKRENFFEIKLYCVFELIDACLKKIHTLYPSRFLAMTVSSFNNLMFKLTKQHGSLGNYHFVMKRVYSFCRNYISPPLPTNAKEMPQEELDKIVKDEEYLQRRLLTGFLTQVIYLANINGTEGYSIEHFSWLQQQSKSKIKFVFERDGAFCDRFVELASSFDIDLLKCFQGFITDSHKLLIGIDYKNKNKSEDEIIELLFERVVVDYQKNVLTSIVDSDAKAIKDSIIGELILFTHSIAGKKNFAKPTMSIHDSLVMTLRLIIPQMVNPKFINAGNHDVVVFWVWFALYQQQIINSKNLQLEISYIPKVLLTTFFQCLLFIVIKSEGKPNFKYMLLTLLTKLLTLSPDTGYEFIKDSLNNCPYESVYPSLIGVYKQLLLNEKWDVNSIELEKLNISSSSSNTPPKLPPRNGIKRKHFSLTNESLNDLVDLINNSSKNAFVEDNSKIDPSKLSTIAAYLNLLVAIKKDPVIVENKEKLTTLISSIENKIKSVKKSSQNQFELNAAGMLEITIERFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKW0</accession>
    <name>Q5AKW0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dur32p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DUR32</name>
        <name evidence="9" type="ordered locus">CAALFM_C113800CA</name>
        <name evidence="8" type="ordered locus">orf19.12484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722221.1">
        <property type="nucleotide sequence ID" value="XM_717128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKW0"/>
    <dbReference type="SMR" id="Q5AKW0"/>
    <dbReference type="STRING" id="237561.Q5AKW0"/>
    <dbReference type="GeneID" id="3636142"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113800CA"/>
    <dbReference type="CGD" id="CAL0000198226">
        <property type="gene designation" value="DUR32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13800C_A"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AKW0"/>
    <dbReference type="OMA" id="GVSGMHF"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF3">
        <property type="entry name" value="DUR32P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000198226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="671" mass="73132" checksum="7BF0C2985EEEAA38" modified="2005-04-26" version="1">MSESSVHLLNQAAGYGVLIGVGALFAGGMILTTFLLQKYLHENANSTETFSVANRSVGTFLSASAVYSSWSWSTEFLFVSSMTYNYGVQAGYYYGAGLAIQIAVMSVIGIHAKKRIPTAHTSLEAVQLRYGKAAHLLYLVLSLICNICSCSAMILACASGISIIAGNLHIVASTMLIPFGVLLYTVVGGLKATFLTDFVHTTVLLVVLCYINTAVLTSDQVGGIDGLYDKIIEVSKTKFIEGNYDGSILTGKSKGSVIFGLVLTAGNFGLTVMDSSFWQKTFSASPRATVPAYLLTAFLIFSNVWPISAIIGGSSHFLESDPSFPTYPRKMTQYEIDSGFVLPYVLKAILGNGGVGALLLILYLAVTSTVSAQMVSVSSIVSFDIYKKYIHPNAQNKSMINVSHITCVVFGLGIAGFSIMLHYVGVNMTWFGYFIPMAICPGVIPLIFTVTRDRQTFWAAFISPIVGFAAGLAVWISTAYHFYGSVTIESTGGQLPALYGSLTALLLPGTLSIIISFIKPEKFDWEKLKQVNLLVDGDSSSEVEIDNDTPTIPKEKQDGVEVNFESDETSSLEQQQQSQAASQLTVKEMDFWIKISTGSVIFILLVTWVIWPMSVYRDWVFTASYFKGYVTVALIWLYTTLIVIGLVPFYTGRHSAAKVFRGVYNDYIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKX2</accession>
    <name>Q5AKX2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fumarate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">OSM2</name>
        <name evidence="11" type="ordered locus">CAALFM_C113670WA</name>
        <name evidence="10" type="ordered locus">orf19.12472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
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        <scope>GENOME REANNOTATION</scope>
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            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
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    <name>Q5AL00_CANAL</name>
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            <fullName evidence="10">Serine/threonine protein kinase</fullName>
        </submittedName>
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        <name evidence="10" type="ordered locus">CAALFM_C113470WA</name>
        <name evidence="9" type="ordered locus">orf19.12446</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="282"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000194707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="666" mass="77020" checksum="51C36548FB65C90A" modified="2005-04-26" version="1">MISNRKRPRVLSTDGHSSVSNDTATNSTNLSDTPPFSHHHHHHHSQQSQQQQQQQMPILSDTSTDSSNSSFPFYKPLLKSSKIESSMFTNPFLSIHDRNGIQLPEYGDDDDNEEDEEDEISDNVLDNDDDDNYAIEDDDEEVDEDEIVDIEDDDDDIEEIDGFDNDDDIIFIEQRQLPKRNSDSLLYDTQALEAYNKFRSNKNNNNKKKLPPARIKKQRTNSLPQLPQAKCIYNKLPNYILQGPKLGNIRTNVIPHQLNLPPCVDESGHYIVKPNTLFANRFIIIKLLGQGTFGKVVQCFDKVKNEHVAIKIIRNIQKYRDAAKIELRVLSTLKKFDPDNTNHCIHLRECFDYRGHICIVTDLLKISLYDFLENNKYIGFPGSQIQSIAKQLIRTVCFLHDLGIIHTDLKPENVLLKDDSYHKLKITSSTMTSAYLALKNDKRPVKFSKILSLTDIYVIDFGSSIFDSEYHSSVVSTRHYRAPEIIFNCGWSFAIDLWSVGCILVELIIGEPLFKTHHDQEHLHMIQKISGETIDRKMVLMCKKQGHKVGEYFDDNCRLIELEEPKFIQSVAQLDRIDKFISKRLGINLDLNLSLEENYDLNRDNQEEDDDKDEEDDFDENKILFYYYFVDLLQSLLKINPQERITAEEAMNHPWFDLGTIDEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AL34</accession>
    <name>Q5AL34_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">PSA2</name>
        <name evidence="8" type="ordered locus">CAALFM_C113160WA</name>
        <name evidence="7" type="ordered locus">orf19.12409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722154.1">
        <property type="nucleotide sequence ID" value="XM_717061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AL34"/>
    <dbReference type="SMR" id="Q5AL34"/>
    <dbReference type="STRING" id="237561.Q5AL34"/>
    <dbReference type="GeneID" id="3636159"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113160WA"/>
    <dbReference type="CGD" id="CAL0000185249">
        <property type="gene designation" value="PSA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13160W_A"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AL34"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="334"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000185249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="458" mass="50817" checksum="9B356284F65485A6" modified="2005-04-26" version="1">MTLKVLILVGGETTGTRFRPLSMECPKLLFPLCGKPLVSHIIDNLTDQFPIDDLEILLMGFFKGQHKTMFQDYIQNVNKSNPDLRIKYLSEPFPLGTAGGLYHFKDEIFTDSNCKLLMIHGDVICNYPFKDMLEFFEQTKSNITLYGVDPVSLLKRSQAQILVVNGTENGDEAHDDDIVTKFGAIVAERKNSKVVHYVEKPSSSISEFRQDSTFEILLNGGIYIFDRSILDLLTSAEIKKKNSIQFDDGLDDNDSNDNDNSDNVLSLELDVFKTLPQLDNTNFNVFKSNGFWYQLKSPLSALLANNFFLAQSGGTKLSAGVELVQPVQILTESIAQAKSCKIGPNVSIGKNVTIGNGVRMVNCIVCDDVTIGDNTIIKNAIIANGTKIGKWCRIEGTITASILASNVISSSSAAYMKSLNDIVILCQNTVVHNQVFVYNSVVLPHKELKKDVKYEIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALJ1</accession>
    <name>Q5ALJ1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hgt20p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">HGT20</name>
        <name evidence="11" type="ordered locus">CAALFM_C202610CA</name>
        <name evidence="10" type="ordered locus">orf19.9160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722629.1">
        <property type="nucleotide sequence ID" value="XM_717536.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALJ1"/>
    <dbReference type="SMR" id="Q5ALJ1"/>
    <dbReference type="STRING" id="237561.Q5ALJ1"/>
    <dbReference type="GeneID" id="3635863"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202610CA"/>
    <dbReference type="CGD" id="CAL0000200088">
        <property type="gene designation" value="HGT20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02610C_A"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="Q5ALJ1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015749">
        <property type="term" value="P:monosaccharide transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000200088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="503" mass="55436" checksum="F9792D7E67DA0B95" modified="2005-04-26" version="1">MPNPTSIHNFLDKRHSITPLLGWSTFIICLSALQFGYHLAELNAPADVLSCNVKKPGPLPSYNNTIWSHFHFNQCINMTEQGVTLITTMFTIGGLLASIILGTTSISTNYGRKHLCVVAALFYVSGSFLMSFSQTNWQINLGRLLNGFGAGSSLIVSPILINELAPLNHRGLLGSLMQSAVSIGIFIAQIVSYLYSNDQQWRLIFLVAGLIGFVQFVGLLTVPESPKWLTMAKNDVERATLILKGLRTDESTVDYEIHHWGNLTTTNLPDDETSSLLSDDSLSSRNPPSIPTKDFIMERKYRKQLIAVVLIMTGQQLVGINAITYYGVKILNELFSGSNTGNLVLMLNCVFSGMNVAASIAVAPLIDRWGRKPLLMTSITMCAICTSILAIGIPNRYDIAVVTACIGFVTGWALGLGPLPFLMISEFTGHDVVATAQSLGTVMNWSSNMFIAILFPFLTNILGIGMVFWVFVINSLVYGFGFYHYVPETKGFTHYRDVWEHFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANI6</accession>
    <accession>A0A1D8PJZ4</accession>
    <name>STP3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator STP3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">STP3</name>
        <name type="synonym">STP1</name>
        <name type="ordered locus">CAALFM_C304580CA</name>
        <name type="ORF">CaO19.13338</name>
        <name type="ORF">CaO19.5917</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E27434" last="E27434">
            <title>Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans.</title>
            <authorList>
                <person name="Davis M.M."/>
                <person name="Alvarez F.J."/>
                <person name="Ryman K."/>
                <person name="Holm A.A."/>
                <person name="Ljungdahl P.O."/>
                <person name="Engstrom Y."/>
            </authorList>
            <dbReference type="PubMed" id="22110651"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0027434"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="9435" last="9446">
            <title>Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control.</title>
            <authorList>
                <person name="Martinez P."/>
                <person name="Ljungdahl P.O."/>
            </authorList>
            <dbReference type="PubMed" id="16227594"/>
            <dbReference type="DOI" id="10.1128/MCB.25.21.9435-9446.2005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
        <scope>PROTEOLYTIC PROCESSING</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Mol. Microbiol." volume="69" first="586" last="602">
            <title>A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans.</title>
            <authorList>
                <person name="Dabas N."/>
                <person name="Morschhauser J."/>
            </authorList>
            <dbReference type="PubMed" id="18547391"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06297.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Transcription factor that activates genes required for degradation of extracellular protein and uptake of peptides such as the secreted aspartyl protease SAP2 or the oligopeptide transporter OPT1. Required for virulence. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is down-regulated in presence of extracellular amino acids.</text>
    </comment>
    <comment type="PTM">
        <text>Activated by the amino acid-induced proteolytic removal of an N-terminal inhibitory domain.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 6">Impairs expression of SAP2 and OPT1. Impairs virulence in Drosophila as a host model.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723130.1">
        <property type="nucleotide sequence ID" value="XM_718037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANI6"/>
    <dbReference type="STRING" id="237561.Q5ANI6"/>
    <dbReference type="EnsemblFungi" id="C3_04580C_A-T">
        <property type="protein sequence ID" value="C3_04580C_A-T-p1"/>
        <property type="gene ID" value="C3_04580C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635152"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304580CA"/>
    <dbReference type="CGD" id="CAL0000188272">
        <property type="gene designation" value="STP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04580C_A"/>
    <dbReference type="eggNOG" id="ENOG502S4NK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036916_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ANI6"/>
    <dbReference type="OMA" id="IFPVNCA"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="PHI-base" id="PHI:11403"/>
    <dbReference type="PRO" id="PR:Q5ANI6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002194">
        <property type="entry name" value="STP1p Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF19">
        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_0000426058">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000426059" description="Transcriptional regulator STP3">
        <location>
            <begin status="unknown"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16227594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18547391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22110651"/>
        </source>
    </evidence>
    <sequence length="436" mass="49092" checksum="D89A0347A6A4655B" modified="2005-04-26" version="1" precursor="true">MLILSIGLIHHTSNKSLYTISPNKGKRYEPFTTTSLGNFQFHVVRFLHRLIYGTQRYQELFPPIQKIKNINNVKQQRIFPVNCAADDLDLGFGESDQIELFNHPSKDTYGQFNLIQLIDIFDPPQVHAPSSADEFFKSNKGSEHIDIFDMITRQPPPFHQHQLNIETPYFEDFATPLVLPPHEVSSDDVESYFSGSVSTVSSIEPLDDEFVPPPQPPRTHTSRKRKHDSISPPASSDSSSSSSYVPQLIPSSSSSVTSNGDSPVSPTTKRKYTKKKQPVFSNVDEPIVITTTTKTNNIDVKKITTTKNGTVENRFDCPSCDASFKVKGYLTRHLKKHSTSKAFECPFFDNHGVHGSKCHPTGGFSRRDTFKVHLRALHFIYPAGVKASQRNSFNGRCAGCFQYFDNNSEWLENHIEAGKCTGTVQYKQNVSNLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PC97</accession>
    <name>A0A1D8PC97_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">TUB2</name>
        <name evidence="17" type="ordered locus">CAALFM_C100710CA</name>
        <name evidence="16" type="ordered locus">orf19.13455</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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    </reference>
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    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
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        <name evidence="5" type="ordered locus">CAALFM_C103520WA</name>
        <name evidence="4" type="ordered locus">orf19.10572</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <location>
            <begin position="237"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="481" mass="54909" checksum="3769379DF9D8F1DD" modified="2017-01-18" version="1">MPESKDIKMKDVQQDDVSSEIDTLVKEIEQSFILLSKVATTFDNRYVSKVFRDLGPLRRKLVKNGNSVLATVINNTYPQTHNSKKYLLKYLNESPTSVGNDAMDVDNTTLIPEIELYIHLLVQVYLLDTGKLEELNSLGEHVVQLMKSFNRRSLDFIQAKVWFYVCRAKELIGDLYSIRPELSYSLRTATLRHDIETTASVITLLLRNYLLTHDISQASDLVEKVEFPENAGNALVARYYYYLARINAIQLDYSTANECVITAIRKAPQTSLANGFVQAATKLSIVIELLMGDIPELKVFKNKSGNLEPYFNVTKAVRLGDIKLFGEVLHKFEADFKKDDNFTLVSRLRQNVIKTGIRIISLSYSKISLKDICIKLHLDSEESTEYIVSKAIRDGVIEASINHQKGYMQSKELLDVYSTKLPQAEFDQRIKFCLSLHNESVKSMRYPNDNEKENANKEIEPSEEVELLKAIEEGDLDDFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDC5</accession>
    <name>A0A1D8PDC5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">IFE1</name>
        <name evidence="10" type="ordered locus">CAALFM_C104750WA</name>
        <name evidence="9" type="ordered locus">orf19.8391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713579.2">
        <property type="nucleotide sequence ID" value="XM_708486.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDC5"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5363962at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="335"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000197952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="394" mass="43087" checksum="7C3062349F15F149" modified="2017-01-18" version="1">MKAIVYHDRGDIRYDPNFPDPQIIRSDDVKIKVHYCGICGTDLKEYSDGPIFFPPKGELNEISQMESIQVMGHEISGEVIAIGDDVTNVKVGDKVVVEVTGTCLDRHRYQDSKNGDSPKPNCPSCVSGNYNACDYLALIGCGFANGGCAEYLVVANSKVIAFDQDKIPMDIAALIQPIAVSWHAVKVSNFKPGSNALILGGGPIGLTTIFALKGNQVSQIVLSEPALARRQLAEKLGVITYDPTGKSIEQCVEDLKKLSPGGYGYEYSYDCSGVKATFETGLKTLKIRGCATNVAIWAHKSIPLYPMEITLSEKMLTGSICFVKKDFEESIKAIENGLISIDELKMLITSKIHLQDGIEKGFLELINHKEKHIKILFSPKSEYLLSNGVNDSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDF4</accession>
    <name>A0A1D8PDF4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Exosome nuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">RRP6</name>
        <name evidence="12" type="ordered locus">CAALFM_C105050CA</name>
        <name evidence="11" type="ordered locus">orf19.7719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710869.2">
        <property type="nucleotide sequence ID" value="XM_705777.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDF4"/>
    <dbReference type="SMR" id="A0A1D8PDF4"/>
    <dbReference type="FunCoup" id="A0A1D8PDF4">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDF4"/>
    <dbReference type="GeneID" id="3647535"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105050CA"/>
    <dbReference type="CGD" id="CAL0000183418">
        <property type="gene designation" value="RRP6"/>
    </dbReference>
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</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Candida</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW26223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_710753.2"/>
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        <property type="gene designation" value="orf19.8041"/>
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        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
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            <begin position="28"/>
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    </evidence>
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        <source>
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    <sequence length="339" mass="38949" checksum="0A5431A8381702B6" modified="2017-01-18" version="1">MSINPNLKLFKLINNRKNNNNSTDTMNSQQQQKSQQQSQQQHQHQQKNKYNSFDATSSILSDYDDLEVIDDDQSSYVLFNPKSLASSSRGKQKSQHHDSDILSFTNTSNTNDEYQSDTEKEEEDSEIEEEEEEEDEAQEDDRVSIDDEHNDTEVLNRDRLSHKINSWYTANVVSSSHHQSLIDERIASWELDEEANILESSQESSKSLEESKSILREFYGDDLFKYLNQDEIAKVKKFHKMVDIKNYLLDKTNKNNNSLLDQLLYKVLLFKEKKHNDTTFHRQYNIGTTDYINYLTKDVPSYSPAFVAPSTISDTTTGGSSLIMCGGVGFGGSASWNDI</sequence>
</entry>
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    <accession>A0A1D8PDM8</accession>
    <name>A0A1D8PDM8_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
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        <name evidence="6 7" type="primary">POL32</name>
        <name evidence="7" type="ordered locus">CAALFM_C105850WA</name>
        <name evidence="6" type="ordered locus">orf19.10002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019475131.1"/>
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        <property type="gene designation" value="LTP1"/>
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        <property type="term" value="F:protein tyrosine phosphatase activity"/>
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        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LMW_PTPase"/>
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        <property type="entry name" value="Ptyr_pPase"/>
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        <property type="entry name" value="Ptyr_pPase_sf"/>
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        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
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        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
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    </dbReference>
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        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
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        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000199576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="168" mass="19247" checksum="5B59D8F33093BA70" modified="2017-01-18" version="1">MAPKFDPKEKQISVAFVCLGNICRSPMAEAIFKHQVEIQGYSPFFKRIDSFGTSGWHIGETPDSRSSKTCKKHNVPVSHHAQQINSSDFKDFDYVIGMDESNVANLRHLKPRDSKTVVELFGHWKTSDEFKTIVDDPYYGGIDGFEYNYKQICHFTDEFLKQEIGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEG7</accession>
    <name>A0A1D8PEG7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arg81p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">ARG81</name>
        <name evidence="9" type="ordered locus">CAALFM_C109090CA</name>
        <name evidence="8" type="ordered locus">orf19.12230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PEG7"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEG7"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PEG7"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C109090CA"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QQBG">
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    </dbReference>
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    <dbReference type="OrthoDB" id="3477330at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="912"/>
            <end position="962"/>
        </location>
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    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="877"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="1099" mass="124638" checksum="898ADEB250A311DC" modified="2017-01-18" version="1">MSSPSILSKNIEDKSSTTEIAPPPTQPQSQPVTTTTTTTRRSKTFTGCFTCRSRKIKCDLTKPQCEKCTRAGLICAGYDIKLRWSDPIQYIPTKTGNVKSQPIKFTNKDDEQLDENNNSKNNNNSSSEFFQRRKVGFVKWDEPYETYEDMDSDLSILHGSGEDPIVKLSGETKLKGPFGVFKGEPSPQQQNNIISQEISLKSKKRRLNNSHNDTNVIATTTTTTTTTGTTSNVSNTYTNGSSPLVHGHNFTTTTTTESNSQPHGYNLETGIPHSDQPQDSQWISNELKDAALVTAAALDTQFLDLMFNFNSNIPTDDTSNNINNNTTTNTHTHTDNQTNNNNNNTGHSSIMDEFNNPDFLNLLFHKNSQLAITTPQPHIGTTTHTTTPQLSHSNSSISLANILNQNQGANNNSNSILMDPTYYSNFSNFFYNNPYQSNENLEIDLHAKSIDHDHDHDHDEDEDDESPEEVDGNDSKLLQFIMKIVKNPTNLPFDLSLPSNSNEQQQQQQQQQQQEHHHHHQIGIPVNALQVQPLTRYLLNYYVTNVADLMTVIPLTESPWKTIYFPRALMALGELSALGKTSTAKNALLNALLAVSAFNLQSKFPKNSEPMRFYLNLGIALRNQASLFIKQLLHNKRNNKRNKTNGIEYCINHEKYKDVLCAVLSMISVDLVWGTMQDTRIYITWCGKVIIAKMQNKKKLSTKASILHRIFSNLKLIQDSTCLDIDSINEDFETNYYGIGIGTGTGIGYDVSGDKYVQQKLDNSDGDATTTTTAVVDDHKKVRKTRIDFIVNNTFTNKKQTKTTTTTTTNKSKSSITTSPSFVNKKLINTMKNDESFATDALYGLPYSLIVLFSETVELLRTKIYYRDNPKAAARIAMKLSNHEKEFNDRIEELNEKLENWTLDWQLYEQQQQQQQNMTTTKAKTRSTTPTSSPTPTDGKPENEEPTTVGDDNDNDDNNEFDHKFYSPMHKATYHHIMSFYHALMIYFNRLIKQIPAENLQNQVKKTLQHLNAIQKLIDDKEANIIPLFWQGFIAGCEAIEPDLQLAFKQWGADIAKYLGSYWGARQIMMEVWRRKRANEIKDDWISVIHDWEMNLMLA</sequence>
</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_708809.2"/>
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    <dbReference type="SMR" id="A0A1D8PF23"/>
    <dbReference type="FunCoup" id="A0A1D8PF23">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PF23"/>
    <dbReference type="GeneID" id="3644397"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11190W_A"/>
    <dbReference type="eggNOG" id="KOG0076">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
        <ligand>
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        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000188016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW26744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="255" mass="29173" checksum="2159F04FF64F5332" modified="2017-01-18" version="1">MFHLASSLYTQYTKREQYNILILGLDNAGKTTFLEHLKLLYSSSTESANKNQLSKNSTTSDDQPRSTSDVIKSKRILPTVGQNTTTIKFESKDSDSPLASQFKNINLKFWDLGGQKSLRNMWSRYFKQCHGIIFIIDSTDTERFQECYETLIDIAHDDIWMQIDDDDDNDNDNSNVDGTVNVPILMMANKQDLPQAVDLVSLKTGVFIKLVSELEATDSKLLPVSVLENQGLQESLEWLVTRLIYNKRNKKPEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFI5</accession>
    <name>A0A1D8PFI5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C112740WA</name>
        <name evidence="3" type="ordered locus">orf19.13704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711566.2">
        <property type="nucleotide sequence ID" value="XM_706474.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFI5"/>
    <dbReference type="STRING" id="237561.A0A1D8PFI5"/>
    <dbReference type="GeneID" id="3646819"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112740WA"/>
    <dbReference type="CGD" id="CAL0000178218">
        <property type="gene designation" value="orf19.13704"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12740W_A"/>
    <dbReference type="eggNOG" id="ENOG502QWTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="470"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="773"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
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            <begin position="679"/>
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        </location>
    </feature>
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    </feature>
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        </location>
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        <location>
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            <end position="901"/>
        </location>
    </feature>
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        <location>
            <begin position="913"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PFW1_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Protein-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">CAALFM_C114160WA</name>
        <name evidence="2" type="ordered locus">orf19.7223</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715024.1">
        <property type="nucleotide sequence ID" value="XM_709931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFW1"/>
    <dbReference type="FunCoup" id="A0A1D8PFW1">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFW1"/>
    <dbReference type="GeneID" id="3643322"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114160WA"/>
    <dbReference type="CGD" id="CAL0000185918">
        <property type="gene designation" value="orf19.7223"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14160W_A"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFW1"/>
    <dbReference type="OMA" id="EVDAYHE"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="584" mass="67153" checksum="B37E92AE5EE9DBBE" modified="2017-01-18" version="1">MSSTLSSKVEPLKNWLNKNSFWREDLIIKESPYGGIGVFSQGPIDIEEDPLLLRIPKANLLAPKNSYIYNLLVDYEPENPDIILSEGMFGLVLTVIYELQCHDSSPWFEYLQTIDFNNSQIPVCLWDTVDKDNSKNTQLDLLNFLDPQELIDFYVEAIRFAHKNSDTLPIPSILNIDNPDLSPKLLSEKHNDKLIEFGKVIQSVISRAFSIDNYYQLALVPAADLFNHLSPKTKDGKVIDRENIHFVCDGTVCEVCGEQECDHEEEGEVVDDDDDDVDNIEQEPRKSSDDSESITSISMDYIYEMEQDELSDADTDVDPEEASTLSMEEEIAVNGADHDLANELSDSSKCCDVVLIREPQEQHEFEIFNSYGNELSNAQLLQKYGFIDMDDNPNDTCLLSIQFFKQLKTLKEKLGNPKKAKELDQKIEWLEEIGYELINEIISAEDMEHNHDEEDCQDESCDQKDAEVIFPESWPLSIFVKNIDGSCSPQTYAILKLIELKHPYFVQKLEAIDNEKILIKNIQKYLLNYTEKELKSFNKTVSNWCKNRLQKYPDSIRSSKHSEQISTIINQEKRILHKFIDLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG09</accession>
    <name>A0A1D8PG09_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stf2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">STF2</name>
        <name evidence="3" type="ordered locus">CAALFM_C200250WA</name>
        <name evidence="2" type="ordered locus">orf19.2107.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330735.1">
        <property type="nucleotide sequence ID" value="XM_019475190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG09"/>
    <dbReference type="FunCoup" id="A0A1D8PG09">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PG09"/>
    <dbReference type="GeneID" id="30515083"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200250WA"/>
    <dbReference type="CGD" id="CAL0000185307">
        <property type="gene designation" value="STF2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00250W_A"/>
    <dbReference type="eggNOG" id="ENOG502S4WH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PG09"/>
    <dbReference type="OMA" id="KWTVHES"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="89" mass="10495" checksum="2C9BC71205484F98" modified="2017-01-18" version="1">MTRTNKWTVHEKRPQEPKWFTHNGHSDTDPTKVKKNGAGKNNWGQPGDELDDNEVRHYQKSSGRRNSNHEMNQERLNNLNDKLDNQLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGG5</accession>
    <name>A0A1D8PGG5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C202000WA</name>
        <name evidence="9" type="ordered locus">orf19.9089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722559.2">
        <property type="nucleotide sequence ID" value="XM_717466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGG5"/>
    <dbReference type="SMR" id="A0A1D8PGG5"/>
    <dbReference type="FunCoup" id="A0A1D8PGG5">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGG5"/>
    <dbReference type="GeneID" id="3635767"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202000WA"/>
    <dbReference type="CGD" id="CAL0000177575">
        <property type="gene designation" value="orf19.9089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02000W_A"/>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGG5"/>
    <dbReference type="OMA" id="GETWNLL"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000177575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="340" mass="38541" checksum="69D5564E3F349E95" modified="2017-01-18" version="1">MSTTGLQRRRGAKQSTPKPRNSDSFDESRSPASPNKPDHKIGYDDKDIKDPSTLKQPLLTLMEEVLLMGLKDKEGYLSFWNDNISYALRGCILLELTFRNKITLVNDPARRRFELSDRLVEVIDAEPTGEVLLDEALKIMKNDESNLSVTNWIDLLSGETWNLMKINYQLKQVRERLAKGLVDKGILRTERKNFFLFDMATHPVADKLSKEYIKNRILSMLVSRNVDLDTVSNEQFPADTSFRYLRTVSLVCGAYAANVLENVLLSLNYEKRDQAFARADELLADFSEFPFNLSHQSPLGLGLNLGQEVGDEIEKSSASELQLELIAAVLSVFARMDSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHA0</accession>
    <name>A0A1D8PHA0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C204820WA</name>
        <name evidence="12" type="ordered locus">orf19.7812</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
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</entry>
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        <submittedName>
            <fullName evidence="9">Lysophospholipid acyltransferase</fullName>
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        <name evidence="8" type="ordered locus">orf19.9437</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="CGD" id="CAL0000197966">
        <property type="gene designation" value="LPT1"/>
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    <dbReference type="eggNOG" id="KOG2704">
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        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="39"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="76"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000197966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="602" mass="70030" checksum="9C4D9D60795DF20D" modified="2017-01-18" version="1">MISIIQNGISQLSSVSGLDEANLKILICTLLSFPFGIIFKRLPDHDYTLKNIYNVAVSCFYVFGICDLRFGISTLLISATGSYFITRYVRTKSMPWINFLFLMIHMAYSHFHLQFFKEYDPKSIDITGAQMILVMKLSAFGWNIHDGKQPRSTLNDFNKARAITKHPNVLPYIGYVFFYASLLTGPAFDYADYDKFIHGTLFDDVPQDKRPGKNKRRIPRSGVQAFKKFSLGFFWAFLLLQSDKFVTMEYMFSPEFVQYHGLFYRIIYMWILGFTFRLKYYTIWTIAEGACILCGIGYNGVDPETGEFKWNRVQNIDPWSFETGQNVHACLEAWNQNTNIWLKNYVYLRVAKPGKKPGFKSTIFTFTTSAFWHGTRPGYYLTFVVGALMQTVGKYYRRNFRPIFLEADGKTPKPTKIVYDFVCWVNTQLAFGFFVQPFVILGFTKSLECWATVYYWLLWVIAISFFAFSGPFAKSVSKFFKSLQPSYREQQRKSREDKYKLNNEEASIVEQAVGAKLGQDYDIPALGLPPFDVFTDFDQTEVDHDIQHLRKAWTSFRGRRGSITENDFDGLKDAYNNFTNEINDIFNTKKEEFKKEKLNKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHZ9</accession>
    <name>A0A1D8PHZ9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C207760WA</name>
        <name evidence="7" type="ordered locus">orf19.9749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716044.2">
        <property type="nucleotide sequence ID" value="XM_710951.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHZ9"/>
    <dbReference type="SMR" id="A0A1D8PHZ9"/>
    <dbReference type="FunCoup" id="A0A1D8PHZ9">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHZ9"/>
    <dbReference type="GeneID" id="3642298"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207760WA"/>
    <dbReference type="CGD" id="CAL0000181552">
        <property type="gene designation" value="orf19.9749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07760W_A"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHZ9"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="186"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000181552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="368" mass="41047" checksum="85AD8966D34DAC1E" modified="2017-01-18" version="1">MSFYSKYIKPNIGLSLLLLSQFLNSIMVTTCKLLVTDKNFNTPIHPAQILFVRMFITYICCLLYMAITRSVPDAPFGLKPIRKLLLLRGLVGFFGVFGMYFSLQYLSLSDAVALTFLVPMVTAFLAFVLLHEKYSILEAICSVFSLAGVVLIAKPTFIFGNESNKETGNDETIESSSSEKRILATIVGLIGVCGASSVYIVLRKIGMNAHPLLSVSYFALTCCIVTFLAILVIPSLTFVLPTNAYQWTLFFIIGFSGFFMQFSLTAGVQRVKAARASLMAYSGMIFAVVWDLTIWHHFPGILSFLGITLIIGNAIIILKFKPQQEEITDKQGDDIERNGKYNRVDDSITMQDFIITDDEEEENVRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI17</accession>
    <name>A0A1D8PI17_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rnr22p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">RNR22</name>
        <name evidence="5" type="ordered locus">CAALFM_C207570WA</name>
        <name evidence="4" type="ordered locus">orf19.9424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713125.2">
        <property type="nucleotide sequence ID" value="XM_708032.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI17"/>
    <dbReference type="SMR" id="A0A1D8PI17"/>
    <dbReference type="STRING" id="237561.A0A1D8PI17"/>
    <dbReference type="GeneID" id="3645217"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207570WA"/>
    <dbReference type="CGD" id="CAL0000192458">
        <property type="gene designation" value="RNR22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07570W_A"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI17"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000192458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="394" mass="45735" checksum="BFB9DC83AC10A896" modified="2017-01-18" version="1">MSKNTDNNKPSPKKVTEKSTPIVTKPESDKTVEKASDDSEIDLPEVYKRHKEFLAKHVVNRHKLKQEESNEPLLTPDKTRHTIYPIKYPELWQFYKKSLASFWTAEELDLSKDLDDWNNKMNENERFFISRVLAFFAASDGIVNENLVENFCAEVQIPEAKSVYKFQIMMENIHSETYSLLIETYFKDPEEADFLFNAIDNIPFIRKKADWAIRWIQSEDALYAERLVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELICRDEGIHTDYACLLFSYLKNKPSSEIIEKIITEAVDIEKEYFSDALPVSLLGMNCDLMCQYVEFVADRLLVAFGNKKYYNVTNPFDFMENISLAGKTNFFEKRVSDYQKAGVMEKVENKNEKTGLFDQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI61</accession>
    <name>A0A1D8PI61_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Msu1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">MSU1</name>
        <name evidence="3" type="ordered locus">CAALFM_C208550CA</name>
        <name evidence="2" type="ordered locus">orf19.11107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714466.2">
        <property type="nucleotide sequence ID" value="XM_709373.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI61"/>
    <dbReference type="SMR" id="A0A1D8PI61"/>
    <dbReference type="FunCoup" id="A0A1D8PI61">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI61"/>
    <dbReference type="GeneID" id="3643919"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208550CA"/>
    <dbReference type="CGD" id="CAL0000186154">
        <property type="gene designation" value="MSU1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08550C_A"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI61"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="640"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000186154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1146" mass="131570" checksum="990FBA8C42D65AB2" modified="2017-01-18" version="1">MLRLQEVHIRKCYGSKIILKHNLHISSTLLYNKPSIPSSRRSRSKQKFTSKSKYDDSFFKNIFQENKDNKSKSIETQSQDTHQEVKTSGLEKIQNLVKSKVKSRSIFDSYANLRIDITKPNDELVRSIIKNTKTMNKKRFTDPATSWLSNFSQKEIQELQDFLNNDLPINGTINGKTMETPVKIGDLVTLGSESLRLYLVTSVPKTFNSRICTFLSDRGEIMFAPFSTIGYRFSGLIPDKYHKNIEKFVVLEQKYLNIPPIGIPDAVFSKSNSALPKELQDRENGTKKVVTEEKEEVVDVDGNGDPDESAYLDPNDFIVQQASSQLLSNTDVQTFIVPTTVRQIYVPALLQISNEAFWKMGPMYRKLEELHRSLQVDDNNGEFNTPRTVSIFEILSKLKQPTSEQSTSTIKLGKSPTNSIDYDQRQYKISDVMAVLSLLKKQSHLWTILPCKSSFTPTKVTIWPLAQTKEEERTVEYLNNDDGLTEITKYCGQVALGQKPANTKPIFYNNVEKMLREYVNGKYKDDASISTTLVSLLRKVDKYFVELGIPLKEEAYKNEYSYGKAYDLLTKLNNDVVVNPLLWSEQANLPTEENASANTLTKQKFYNYMDQELANETPNEILQNTIANEIYNEDPLQHLRQDMREIPIYCIDDPTAHEIDDGISIHEDQQDYIVSIHVAEPSSYIKPESIISSLAFEKTSTSYMPDTAFPMLPKLVSDIAGLGIPDKDTRTFVIQYRVDKKTVDEYISNKVNDKNYKVDQLLLDQIISQINESSNIIFATVSNFRQGFTYDKVNEVLNDEIKINQYKSMGQSNDLDFNNLIKLQYISSLLWEIRKSNHAYTNSGNTKLMVKKNNTSNTNCDTEFIYDANELQMKLANSNNTVSIGFANLESASIKLVTENMIIANYLTARFATTNNIKILYRYLDPKFNDELLSEYQKLMKLSDTNNNTSIPTDQLTQMFPFFTRGLVTDKPQKHLLMGLSMYSNITSPLRRYIDLVNQWKIQDFFLGKQQQQQQQSRIDDKNIPAIASYLNGQGEIIRNIQSRANTFWQGLFLRNYQDLKNNYNHNHNHNPIDFKLKLITNPTMGPTVGVYIPNFRFINAHVEVSSEMLEDFKSGQLKIGGLIDSNKLHLKQVDFLENEVIFEYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI71</accession>
    <name>ERG9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Squalene synthase ERG9</fullName>
            <shortName evidence="6">SQS</shortName>
            <shortName evidence="6">SS</shortName>
            <ecNumber evidence="1">2.5.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ergosterol biosynthesis protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FPP:FPP farnesyltransferase ERG9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Farnesyl-diphosphate farnesyltransferase ERG9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ERG9</name>
        <name type="ordered locus">orf19.3616</name>
        <name type="ORF">CAALFM_C208610WA</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Med. Mycol." volume="41" first="417" last="425">
            <title>Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans.</title>
            <authorList>
                <person name="Song J.L."/>
                <person name="Lyons C.N."/>
                <person name="Holleman S."/>
                <person name="Oliver B.G."/>
                <person name="White T.C."/>
            </authorList>
            <dbReference type="PubMed" id="14653518"/>
            <dbReference type="DOI" id="10.1080/1369378031000137233"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG9 produces squalene from 2 farnesyl pyrophosphate moieties (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:32296"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:32300"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4">Expression is induced by lovastatin and fluconazole and is repressed by amphotericin B and caspofungin (PubMed:14653518). Expression is repressed during spider biofilm formation (PubMed:22265407).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27849.1"/>
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        <property type="entry name" value="SQUALENE SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="SQS_PSY"/>
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            <end position="448"/>
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        <location>
            <begin position="428"/>
            <end position="448"/>
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        <source>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="PubMed" id="14653518"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="448" mass="51230" checksum="F9321421BA563311" modified="2017-01-18" version="1">MGKFLQLLSHPIELKAVIQLFGFRQPLHPGKRDVNDKELVRCYELLNLTSRSFAAVIEELHPELRDAVMIFYLVLRALDTIEDDMTIKSSIKIPLLREFDTKLNTKNWTFDGNGPNEKDRTVLVEFDKILNVYHRLKPQYQDIIKSITFKMGNGMADYILDEEFNVNGVATVEDYNLYCHYVAGLVGEGLTNLFVLANFGDKTLTENNFAKADSMGLFLQKTNIIRDYHEDLQDGRSFWPREIWSKYTENLQDFHKVKTPAKEFAGVSCINELVLNALGHVTDCLDYLSLVKDPSSFSFCAIPQVMAVATLAEVYNNPKVLHGVVKIRKGTTCRLILESRTLPGVVKIFKEYIQVINHKSSVRDPNYLKIGIKCGEIEQYCEMIYPNKQALPPSMKSLPENKFTKIVASRESIDLSVQRRIEQENFNCNVVLFGIGALILSLIYFVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIJ2</accession>
    <name>A0A1D8PIJ2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rrp15p</fullName>
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    <gene>
        <name evidence="3 4" type="primary">RRP15</name>
        <name evidence="4" type="ordered locus">CAALFM_C209380WA</name>
        <name evidence="3" type="ordered locus">orf19.563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710002.1">
        <property type="nucleotide sequence ID" value="XM_704910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIJ2"/>
    <dbReference type="SMR" id="A0A1D8PIJ2"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000177236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="255" mass="28567" checksum="65203DE5F236867D" modified="2017-01-18" version="1">MVSVNKSKKSTSIKQTNPNTEKKKTAKVVIEEEEQDQSNSSSQEVESEDESDSELEVADNDDLDQEIGSDDEVNIADASSSEGSDASEDENENEEEDFPKLKKRKTKSTEDGSESFADALNSIVNSKLKAYDRKDPILARNKVTLKKLESDKLEMKAKRALLQEKKVLHDNARVKNLLPTSNEPEKVRQVIEKEKALKKVAQRGVVRLFNAVLSTQIKTNQEVNKEKLGQTKKEEIMNEVSKNKFLDLIAAAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIP5</accession>
    <name>A0A1D8PIP5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SsDNA endodeoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">RAD1</name>
        <name evidence="12" type="ordered locus">CAALFM_C210440CA</name>
        <name evidence="11" type="ordered locus">orf19.12778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717121.2">
        <property type="nucleotide sequence ID" value="XM_712028.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIP5"/>
    <dbReference type="SMR" id="A0A1D8PIP5"/>
    <dbReference type="FunCoup" id="A0A1D8PIP5">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIP5"/>
    <dbReference type="GeneID" id="3641192"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210440CA"/>
    <dbReference type="CGD" id="CAL0000176746">
        <property type="gene designation" value="RAD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10440C_A"/>
    <dbReference type="eggNOG" id="KOG0442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIP5"/>
    <dbReference type="OMA" id="THILDIM"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905348">
        <property type="term" value="C:endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006277">
        <property type="term" value="P:DNA amplification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="10">
        <location>
            <begin position="731"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000176746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="970" mass="111798" checksum="8687B8A4185A1487" modified="2017-01-18" version="1">MSLFVHDDEENDKSTIPLNFSEPDIVPVYPEKAINCILPLKYQQEIVEDTLTKDGLLIMGCGLGWDIITANLLYALSTPFVDSRTKKKKRGLIFVLNAQDDELIRLQEEMNDLNWEDESQHERLVIINGDSQPLRRKKLYAEGGVIAISSRVLVVDLLSLIVSANDITGLFVFHAERIKETSNDAFIINLYRDNNNWGFIKAFSDDPESFSGFTPLATKLKLLRLSNVFLWPRFHVTISQSFNIKNKKDISRKSVTEISVKLTHNMNKIQSAILTCIQSCLGELKRHNPTLATEYWDIENVHDRDFVGRIRGSMNSSWHRVSVTSKNIVSDLSTLTNMLVGLINLDCIGFYQNVQRIVSESQKVQAGSKYRSQSPWLNLDEAVTVISCAKERAFGKRDGNYMFEELPKWNELGKLVHNILQEKRTSNLKNQGPILVVCSSKWVARDLTRLLETMQEEKIGDKRVFSCRRFMKDQLREYAHWRKEINPVVRRIWEEMEAEEQKEDESDIVITKTFTRNGQPVSKRRRTRGGSVAARVNQLRAPENFEAVDIDQEMLLELNEDEPIDQESDSLEFEKTQEENQEVLDLINETEQFQHDFDFVHIDKEEQIIVQAYNDKFNASILQELHPSHIIMYEQNLPFIRRVEVYQAINYENPAHAYFMYYGDSVEEQKYLLRVKREKEAFTKLIKEKATLGKHFETKDDNAKFQINRNNIVNTRIAGGSKFKTETDESNVIVDAREFGSSTPNLLYRIGINVIPCMLTIGDYILSPKMCVERKSISDLVQSFSSGRLFQQCKQMFRHYELPVLLIEFDGTQSFSLQPFSAVKYVRSTRDEPVESEIELNEQSNIQSKILSLLYAFPKLKIIWSSSPYETAQIFLELKANQEEPDVGTALDKGANRTIETGDGNPPMYNDDAIDFIQNIPGINAVNYHILIQQVKNIEELVSLSKDKFISILGDENGKKAYNFLNRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ87</accession>
    <name>A0A1D8PJ87_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C301620WA</name>
        <name evidence="3" type="ordered locus">orf19.9250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721758.2">
        <property type="nucleotide sequence ID" value="XM_716665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJ87"/>
    <dbReference type="SMR" id="A0A1D8PJ87"/>
    <dbReference type="STRING" id="237561.A0A1D8PJ87"/>
    <dbReference type="GeneID" id="3636663"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301620WA"/>
    <dbReference type="CGD" id="CAL0000194274">
        <property type="gene designation" value="orf19.9250"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01620W_A"/>
    <dbReference type="eggNOG" id="ENOG502S52N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJ87"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000194274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="186" mass="21708" checksum="05E2369FA982D8CA" modified="2017-01-18" version="1">MALPTIESFKKLSSEDKRQVLDHLFEPCNTLSNFVFIKVLHQQYNTYPEFINLVRKELLEFLKQSETFQSQYQGEISPVINEIISAHPRLGEPKKETLSVHSNNEQKTLNNDPEIIKKLKELNAAYEKTFPGLRYVVFVNGRSRHEIMDNMQKRIERNDINLERVEAFNAMCDIALDRANKLGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJK6</accession>
    <name>A0A1D8PJK6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA excision repair protein ERCC-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C302770CA</name>
        <name evidence="6" type="ordered locus">orf19.7900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
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        <property type="entry name" value="UGGT_TRXL_3"/>
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    </dbReference>
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        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111131" evidence="7">
        <location>
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            <end position="1447"/>
        </location>
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    <feature type="domain" description="UGGT thioredoxin-like" evidence="8">
        <location>
            <begin position="44"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="9">
        <location>
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            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="442"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1421"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000179466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1447" mass="166121" checksum="65839621F5C99BA1" modified="2017-01-18" version="1">MSIARYIYYTIAVAVLLNFVKATENNNFKLELEASWSNIDFLPSFIEAIVGFNDSLYEQTIETIFGLGDTEVELEDDASDQEIYSTVINSLRLTDQDLDFINFDLTNKKHTPRIAAHYDHYSDVLTKFGDRLKSECAKDSFGNAVETKNGQIQTWLLYNDKIYCSANDLFALRTDLSSHSTLLFDRIIGKSKDAPLVILYGNPTEESTKDFLKILYPDAKAGKLKFVWRYIPSGIKKSDSISGYGVSLKMEKYDYSGAEGNTKYDLSRDFTRINDSQELVLVIGKHSYELGVKLTSFILSNRYKTTKYDLLDTILTNFPKFIPYIARLPKLLNHEKVKSKVLGNEDIGLSQDSYGIYINGSPINPLELDIYNLGTRIKEELQTVKDLVKLGFDTVQAKLLIAKFALLSAVKQTQFRNGNTLMGNNENRFKVYENEFKKGSSEKGGVLFFNNIESDNTFKEYTTDREEAYLGVGSHKLKPNQIPLLKENIHDLIFALNFGNKNQLRVFFTLSKVILDSGIPQQVGVLPVIGDDPMDSLLAEKFYWIAEKSSTQEALAILYKYFESNSPDEVDDLLDKVEVPEDYKVDYNHVLNKFSISTASVIFNGVIYDLRAPNWQIAMSKQISQDISLIKTFLRQGPIEGRLKDVLYSNAKSERNLRIIPLEPSDIIYKKIDKELINNSIAFKKLDKAQGVSGTFWLVSDFTKSEIITQLIDLLLLLKKKAIQIRIINTGDTDVFGKLKTKFKLTALTNGQIDEIIEILKKSNASSANNDELKKMLETKQLPAHHSFLLFNSRYFRLDGNFGYEELDQIIEFEVSQRLNLIPDIMEAYPDEFRSKKVSDFNSVLSGLDNMDWFDLVTSIVTKSFHVDEKRFIVDVNRFDFSSLDFSNSIDVTTYEENSPVDVLIILNPMDEYSQKLISLVNSITDFSFLNIRILLQPRVDSKEEIKIHKFYRGVYPQPTPKFDSNGKWIQHYSAQFESIPSNVTYSTELDVPHKWIVVPQSSSMDLNTINFSESHSVDAKYSLKNILIEGYARDIHTGKAPDGLIFRAFNKNYSTDTLVMTSLDYFQIKGYPSIFNFSTTSNDTLLSASENKYQANTEELESIEVPVFKIDGSTIYPRVMKSGNNKPMSTRKHADINIFTIAGGQLYEKLTSIMIASVRKHNPSSTIKFWILEDFATPQFKHLVELISVKYNVEYEFISYKWPNFLRKQKTKERMIWGYKILFLDVLFPQDLNKIIFIDADQICRADLTELVNMDLEGAPYGFTPMCDSREEMEGFRFWKEGYWSDVLKDDLKYHISALFVVDLQKFRSIKAGDRLRAHYQKLSSDPNSLSNLDQDLPNNMQRSIKIFSLPQNWLWCETWCSDKSLEDAKMIDLCNNPLTRENKLDAAKRLIPEWIEYEQAIEPLVSLVQNNTAKEVVQEIEIDTDGEQEEQEQESNDDDFIHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKR9</accession>
    <name>A0A1D8PKR9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C307430WA</name>
        <name evidence="3" type="ordered locus">orf19.14039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330889.1">
        <property type="nucleotide sequence ID" value="XM_019475344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKR9"/>
    <dbReference type="SMR" id="A0A1D8PKR9"/>
    <dbReference type="FunCoup" id="A0A1D8PKR9">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKR9"/>
    <dbReference type="GeneID" id="3638484"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307430WA"/>
    <dbReference type="CGD" id="CAL0000178648">
        <property type="gene designation" value="orf19.14039"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07430W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PKR9"/>
    <dbReference type="OMA" id="MRLFCMR"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="309" mass="36411" checksum="14CA048A2DABCDAE" modified="2017-01-18" version="1">MGKPKYILIVRHGESEGNCDKSVNRYTPNHLVQLTDNGHCQALQAGQVLSEFLNHASLNNVNNKRNPKSMMFITSPYLRTRQTCNNIIEGIKNVPGVEYKVREEPRMREQDFGNFQPSSDEMELIWKERAQYGHFFYRIPHGESAADVYDRVASFMESLFRQFRSDDFPNILVLVSHGIWSRVFIMKWFKWSYEEFESLKNVPHCKYLVMKKDDETQKYHLKTRLLTWDDVEDDDLDVGQCSLDDDEVYKLIQDQKDTVNSTRNKDKIIEEMYRKAQGPESKYTDYKEKVVSRFKVDNQSVVNSTESFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL91</accession>
    <name>A0A1D8PL91_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C401280CA</name>
        <name evidence="9" type="ordered locus">orf19.12129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722730.2">
        <property type="nucleotide sequence ID" value="XM_717637.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL91"/>
    <dbReference type="SMR" id="A0A1D8PL91"/>
    <dbReference type="FunCoup" id="A0A1D8PL91">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL91"/>
    <dbReference type="GeneID" id="3635700"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401280CA"/>
    <dbReference type="CGD" id="CAL0000181890">
        <property type="gene designation" value="orf19.12129"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01280C_A"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL91"/>
    <dbReference type="OMA" id="HYASIDW"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50128"/>
        </source>
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            <dbReference type="CGD" id="CAL0000181890"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="425" mass="48942" checksum="81575141713254BD" modified="2017-01-18" version="1">MTSIPSDIKLPPSDVKQTIDKTVGYVIKNGKSFEERLLKNNKNDKFTFIKPDNEYFPYYKWKLDTSKKNQGSTETSTENQHQEEDIIIAKPPDLPFLIDLPIISQHDLDVIKITALYIAQNGESKIPKLLQHETKLNNRAQFEFLNESHSLHGLFQKYIQQYKIVIELYQNSHGENADQDQEYLQLRQLIKKPRGEYDILTQAYNRAQYIKQNKVIAKREQEESKARQLHYASIDWQDFSIVAKVDFNAIDAVKELSMPLKRDDLIKRSLDARSKDIELPKVAVAATTTSPVQVEVIDTKNQGSTQDQTDNNTSTPSAPPIKGMKIKAAGTSRLKKSSEANTSMTTTNTIKCPITGKLIPENEFDTHIKTLLRDPRYKKEQENYIRKNFSYASNITTDQVYENIKRFVKKRANVEDENPKKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLY7</accession>
    <name>A0A1D8PLY7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Jen2p</fullName>
        </submittedName>
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    <gene>
        <name evidence="8 9" type="primary">JEN2</name>
        <name evidence="9" type="ordered locus">CAALFM_C404030WA</name>
        <name evidence="8" type="ordered locus">orf19.12767</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMK0</accession>
    <name>A0A1D8PMK0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ago1p</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="5" type="ordered locus">CAALFM_C406340WA</name>
        <name evidence="4" type="ordered locus">orf19.10421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_710465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMK0"/>
    <dbReference type="SMR" id="A0A1D8PMK0"/>
    <dbReference type="STRING" id="237561.A0A1D8PMK0"/>
    <dbReference type="GeneID" id="3642828"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406340WA"/>
    <dbReference type="CGD" id="CAL0000190170">
        <property type="gene designation" value="AGO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06340W_A"/>
    <dbReference type="eggNOG" id="KOG1041">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMK0"/>
    <dbReference type="OMA" id="RGRCYIH"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070551">
        <property type="term" value="F:endoribonuclease activity, cleaving siRNA-paired mRNA"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="CGD"/>
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        <property type="entry name" value="PIWI"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="261"/>
            <end position="367"/>
        </location>
    </feature>
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            <end position="882"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000190170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="917" mass="104146" checksum="BB64EE18D460BB29" modified="2017-01-18" version="1">MSDLVKFSTPTKINDKALVAIDTYKKTFQKQIKNEQNGILLRPSFGTEGVPTIVGVNYFKYNVNGLKLYSYRVDLLEDPNVKTRLSIKTAVEKYLMELEPFKSKKAIIYYRDHNHLYSRMPLPIEDVVIYPLELGGDPKREKKIVELKIQFIKQLNFSDLLNYTQLKNYTPDFLETVEYTNALVAVMGSQVMKNTNVVGLGPNKFFLMDGATKTTDLDKGLYVVMGTFASVRCSFDDVRINLNPTPAIFYKSSKPNGQPMNVLDLIQEFLKIRNVPTERDIRRAQSFIKGCKIYRTYLNRKTTKPILGFDYSNNSETLKFKDANDKLVNVKQYFQERWNIRLKHPTLPLIKIGPEAFLPMKLGIIAPHQQYKGDFADPAKIIKITATRPNQKAELISKTNRNLFQKQVDFGTIESQFTVVPARVLNAPTIEYANNQMVTYRPAPFNGRTEKQKGNWNLERYQFVDGAKLTKPMGKPFTFGVVILKDEFVAKRIGDLQRAVPTFLTELGRLGIKIGKNFKKYSIDLNHASVQSQTGLESNIISIAKKAKTEDQCNFLLFILPRQDTPLYSAIKRACDLKVGILNSCSILNTFTKKRRGTENFDAMTYAQMAMKINIKLGGSNHKLSKKDSQGLFDKNNVPIFILGADVTHPTGEINSESVSIASIVGSEDEIFNKFPGSVRIQTGGQEVIADVKSMVLERLENFHKKIGKLPSKVLFYRDGVSEGQYTTILKEELTKIKAAFNEYGKLKNIPKYSPTITFMIVVKRHHTRFIPIHDNADDPKTKKQIAVTSNENVIAGTTVDREITSPAYFDFYVQSQQSLQGTGIPAHYYVLHDENNYTSDTIQKITYDLCHTFSRATKSVKVVPAAYYADLLCTRGRDYIYGFAKDPNLKGSPIERARTKFGENVNPSIKNTMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMQ0</accession>
    <name>A0A1D8PMQ0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SEM1</name>
        <name evidence="5" type="ordered locus">CAALFM_C406880CA</name>
        <name evidence="4" type="ordered locus">orf19.3122.2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW29409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475400.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="30515287"/>
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        <property type="gene designation" value="SEM1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SBIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="TLWENNW"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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    </dbReference>
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        <property type="term" value="P:mRNA export from nucleus"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
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        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000178710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="93" mass="10747" checksum="1D4EF95811EA6374" modified="2017-01-18" version="1">MSDATKLDSKPSTTIPSKHTSGLTEEEKNVIKTLEEDDEFEDFPEDDSKWSSNSTNKLSEQNLWEEDWDDDDGQDEVSNKLREELKKTIKPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN73</accession>
    <name>A0A1D8PN73_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C501530CA</name>
        <name evidence="2" type="ordered locus">orf19.11624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711352.2">
        <property type="nucleotide sequence ID" value="XM_706260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN73"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PN73"/>
    <dbReference type="GeneID" id="3647062"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501530CA"/>
    <dbReference type="CGD" id="CAL0000200403">
        <property type="gene designation" value="orf19.11624"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01530C_A"/>
    <dbReference type="eggNOG" id="ENOG502T3GY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN73"/>
    <dbReference type="OrthoDB" id="4078100at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="481" mass="55580" checksum="0756359FEC290283" modified="2017-01-18" version="1">MNLSENYISASRNSSSSTATTSMSNKYSSLPKFNNHTHSNQSRIVSNNDMSTSSIFPYNRTVSSSSSIMSTPSNNIRKFQRQRQQERQHHEHLPPPSQHQRQTGSSKNEHINNSSRTSKNGRLIKNKLLNLQQSSKQQLINRISDKDPRHSHSNSSQSNAKKVTPPVFGLQKVASSPYDFSVFTTVATNEKQHDEVLFPAIKQSQIRAWESAEKICRGIIFDDDDDDEEESTDDESENTKNPIISIPGYTEGELKELSKYPNLSSQEEKKLLTEYKRKVLSQREQNLSNNNLISFRRQLQIDQKKEILSKLFNNQNKLNLDYITDNDNNSIDSYTNRNQYNVIDNNLISLDLHSLINNDMEEVNYLLEEDGNFKILQEEVKQNIFHKKIVTDNQQSDENGHGQFDYERFQSLTAKKLDKIYDVHTTRYAGVNVDDDEYKEPSFYSDDVSNLELEEELLQFTTGHLRQCIHDSIDEEEMTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="3643748"/>
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        </location>
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        <location>
            <begin position="7"/>
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        </location>
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        <location>
            <begin position="18"/>
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        </location>
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        <location>
            <begin position="64"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000196133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="328" mass="37761" checksum="B3F0778847057C86" modified="2017-01-18" version="1">MSRESSPEYEEFDETYIETPQRTSNSPRKNKSTNFLSFRTVRSSPLRQPPIERKHGISLDEESIIQSNKSNSISDLPAISNAPSSPPASIRFRNTMRPTRSIEDIPKKESNTTADLNQQFSKHSKDHNFREFGFSRSSKLNTPKSRKLGFREFPEKNIVHSKVSDDVDTYSHSVLEKVNSTLEELHNYDGNWRANSIDNNENSEPTETDPVSVAKKFTENIDLKRQEVLDNSTPIKPLSREGIAQSQIKSGLLQSTWWSSAKWSKLRKIVKSKSISREEAINSTLLMSELECTNKMELRKRYDFLEKYINRNPNRTTTRGKGRVTKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNG7</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Dungan J."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </dbReference>
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        <property type="term" value="P:aromatic amino acid family catabolic process"/>
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        <property type="entry name" value="PLP-dependent transferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000178822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="415" mass="46503" checksum="287A8EE93B02D8D0" modified="2017-01-18" version="1">MINFFKGHPTRELLPVNEIADSYKRVLLDSDYLSYDTDPNNQHPLQYGTDPGNLDVREVIAQWVNKKFGAQVSDPNCINLTAGASYGVGNILTSVTSPKITQRVFVVTPTYFLINSCFVDVGLDDRLTAIEETHNGKYSIDLVYLEQQLQKYSQDLEPVHDDINVFPDPVRGTRKYYRFVMYLVPTFSNPGGLNYTLETRQKLVEIARKYDLLLISDDVYEFLDYTDSKPLPRLNQLDKAGATKYGNTISNATFSKIIAPGLRVGWQETATPKLVDQLSITGSNRSGGTPNQLSTLVVADLIKTGTIDEIIAKFKNVYKERVAVLKESIAKYLPQDTQVYGGDGGYFVWVVTPSANCFDVVAKLAKQNVVLAGGEHFEVTGDKRNWGQHCVRLSISYLTTEEIQQGIKIWGELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPG0</accession>
    <name>A0A1D8PPG0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C600700CA</name>
        <name evidence="14" type="ordered locus">orf19.11143</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711331.2">
        <property type="nucleotide sequence ID" value="XM_706239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPG0"/>
    <dbReference type="SMR" id="A0A1D8PPG0"/>
    <dbReference type="FunCoup" id="A0A1D8PPG0">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPG0"/>
    <dbReference type="GeneID" id="3647074"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600700CA"/>
    <dbReference type="CGD" id="CAL0000178934">
        <property type="gene designation" value="orf19.11143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00700C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPG0"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="13">
        <location>
            <begin position="50"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000178934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW30016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="297" mass="34367" checksum="605A031C71B53F16" modified="2017-01-18" version="1">MELLTIERFLPFLEPFEGKELLTPSECSKLSLIIVEVLVDRYVDFKLLKFLSRFLTQELYDELIEERNIEHACGYIKCNRSPKSLVRRLYIKCNRSPKSLVRRLSMNSNGITQAGSESDPGASTKYQIYNRKPTMILPNTYLSQYCCKEHYQASIFYRNQLSNEALFSRKNIFTTPPFSSDKFNWYENSITCLEEVIAKHKELKQYGKSISEVIAMMNGLTVSDLNNNSELNDETNQLIKLIEDFEIVENNEPNMNGDLEEVDEEGYTQDNEENIHDITNNVEGYVTSNKSFGGYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPI4</accession>
    <name>A0A1D8PPI4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C600980CA</name>
        <name evidence="6" type="ordered locus">orf19.7747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="350" mass="40535" checksum="97B8B912C1137A35" modified="2017-01-18" version="1">MYLGLVLSLFVSQILHLISAHPINDDNSIFIDNRDPTTPIDSEIYSNLYTYAHLIDISYCISEVNRIEEPFKCNLNCEKRFPNISLVYQFYFDDSVTGYIAKTTSNIFRYNETIAEDKKTIIVALRGTRSIFDTLTDLKVDMIPYSNTGTKLPLCGFDCKVHRGFHDYYTRTLSIIHPYIMEELNDCIEDDNYELIILGHSLGGSIAYLLGLHYLDLGFDKLTLVTMGQPLLGNENFVSWGDKVLGSVNEAKHNEFKRKFLRVIHKNDVITTLPRDQNIFNRYSQFDNQIYLNCSETDTRPTINEVIDCYDGSNNQCIAKDFPFLMFERRNYLQIHINYFRQMGLCGILN</sequence>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
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        </reaction>
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    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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        <recommendedName>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        </source>
    </evidence>
    <sequence length="1055" mass="121615" checksum="23B377403427B2F1" modified="2017-01-18" version="1">MAVSRDHYFKLGSELPKERLNAATSLISELVAADNEEEWSYALNRLLKGILTTRQSAKFGFSMALTEVVNELNNRGTLTVGKYLDLLVETTKLTSSMKGKEQRAVLFGRLFGLQVLINSQIIILKSEPEDMLQFVEILMELSNFKNWIRETGIFTLIQFIKLLDNSNVEYSKKIYIKILNMVNNLGLNLSTEGLAIYLSIPQSAQLSQNVSNMKANWKNGDPFYKGNLPILAKVLKDVEVISDEETGDDQKKKNQQKSSWNSRLPFVWDLIVAKFNQVADDSNVEDEMQDSLVTSKKRKKTTSPKHNNKRAKIEPEYISLKEFWKVVVDETLFSEKSSNERKYWGFEIFTKFVTSLETTSSVQYLFTPNFMRCLINQHASSTRMLYKIAQQTLKTLVKTIRETKPELGPIVLSCLLDESKGGCWNFDLISKSHTIDEILQIKTNVNQYINILLENFTIKLQTQTTLDDTSNNNKNSNDNILKWYLDKIVSLIKHNNNNQHKLSDTILESILTKLLQYSFFDTNDIKISKFLQSICKEKFNSILSEIITLKLSHRNYKTWSTFCYKIIDKLSQDPENKCLVEFDDEISIVKQETEELLSTIIELNTKSSDKLYIFELMFSMCLIQLYMEDEETIQVINELKLVFENQFTTANKDDNEEDDNKVDDNLVLTEIVLSFISRKSTLFKKLSVLVWENFLCQVDEIGKLRVNEACFKLLFDVLEAKENKQGQEKLFEGDGEFQESDGDEEDEEEDEEAEEAEDNNENDSSSDIDSDSDNDSDNVSELDNNEDTITEIDKQTNLKLAQALGIPTKESGEVKFDELDDLSSDDDYESDSMDDEQMMAMDDQLSKIFKQRQDTITNLATGNKRKLEVLEAKENMIFFKNRVLDLLETFNKVAVNSHFNLAFIEPLINLMNLTLDKNLGVKAHKLLKNKISKTKIDSEELKKYYNDDPLEYYHQLINLIEELQTKANTTQPSNQSVVQSYNQSCIIIAKNLLNLDESNMQAIVDIYCNSLKQWCLQSESKLQPSLFFDFINWVNSKKSNASHNQNQNQKQKHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQI3</accession>
    <name>A0A1D8PQI3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C700210CA</name>
        <name evidence="4" type="ordered locus">orf19.7101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720392.2">
        <property type="nucleotide sequence ID" value="XM_715299.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQI3"/>
    <dbReference type="SMR" id="A0A1D8PQI3"/>
    <dbReference type="FunCoup" id="A0A1D8PQI3">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQI3"/>
    <dbReference type="GeneID" id="3637983"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700210CA"/>
    <dbReference type="CGD" id="CAL0000186191">
        <property type="gene designation" value="orf19.7101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00210C_A"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQI3"/>
    <dbReference type="OMA" id="FPLLNVW"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="434"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000186191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="788" mass="89329" checksum="609AACAD9B736954" modified="2017-01-18" version="1">MEKDITELKNCPSIERVHEILVANVETPSFPYITALLEFTIPQLFDSIRDSKILIQTFQTLIGLGNLLNRISTRQEQSELYISILERVFDEGLALNLVKGNPSPVEIREINKLVFKGKALAVVNEATTLSSVEITSECFKSTGGYVEYLSNSLLKLYSSNTRSDIIEEFLHSTLKFGDASVIKFYEIFFRESSWDYFVQSFQSMKKFQKKDYLKGLFNNYIVRIAPNSNLNALFNLLSFTSDVFDEMVIESIIQTANKSLTQVVAMILTKSDDYDFLVNKLITKWTNSTVIKNEPISIQESRTFMIMQLISRRKGSALTKDLLTNKQFLNAINNRLSSFSNNIKALGVVLVDYVCELNGEKKIFSLAPEVDTYSLLMVPNVDITELPAHDCWEALKLKETTSPIKIESKQDVSQDLDDDDDDDSLPPQTDVADPIYVKQLIEYFSVDTSNQNAYEMRRKALLKGPTLLHQKYRYGTEVHFYSEELLALLIGLDNHFDDKDFNELKLNNMVAVIVTNPSITTFMFNLLLTGDYSLQQRVLILSATLMAARQLRGFSPTNFPSQTLPEPLHRKYLELEGGSKYIDFIENEVQKELLADASAEAQDQLLGSGKVVRVSSRLKRPAKSTETPTAGFYTIIGKLFYFPLLNVWYEAGTIDIGHYSPVYIGHYIKTLALLIHCAYPSSIQLNDMVKEFLILSCNILRKISLEATPVVESIVTGVLIVCEVSNPEFLVTNHNDEIVFIQNWLSVSWELLVDDKLKSVAAGLLLRLQKLESSLERTIMDQSNSIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQQ9</accession>
    <name>A0A1D8PQQ9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">YML6</name>
        <name evidence="7" type="ordered locus">CAALFM_C700950WA</name>
        <name evidence="6" type="ordered locus">orf19.7019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720313.1">
        <property type="nucleotide sequence ID" value="XM_715220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQQ9"/>
    <dbReference type="SMR" id="A0A1D8PQQ9"/>
    <dbReference type="FunCoup" id="A0A1D8PQQ9">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQQ9"/>
    <dbReference type="GeneID" id="3637954"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700950WA"/>
    <dbReference type="CGD" id="CAL0000188564">
        <property type="gene designation" value="YML6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00950W_A"/>
    <dbReference type="eggNOG" id="KOG1624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQQ9"/>
    <dbReference type="OMA" id="KTFGPHP"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000018">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000188564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="278" mass="31684" checksum="A5FDEC6C1E11D050" modified="2017-01-18" version="1">MFKQSIRSLATKSPISSAAATTTTASTTSTTTTASLNFAKPPSYTLAQLREFPSLEPKTFIPLPTTFFNTEKPIRRDILWSCVTYEADKARVGSNYAILKSDSPYSNRKLRPQKGSGRARLGDANSPHMDNEIKAHAIKGPHDWSTDLPSKIYSRGIQNAFTMHYKQGNLNVVENELDFQYGYDIITQSFVSVHNLNKLNLLFITNEPRDNLMESIKKFYINEKEFNSLNKKEKPKYLQKLKGKVLTKEDVEVRDILRAHRVFIESSALQWFITKHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQS6</accession>
    <name>A0A1D8PQS6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C701190WA</name>
        <name evidence="7" type="ordered locus">orf19.6901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C7_01190W_A"/>
    <dbReference type="eggNOG" id="KOG3969">
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        <property type="component" value="Chromosome 7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <position position="145"/>
        </location>
        <ligand>
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        <location>
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        </location>
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        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
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            <name>substrate</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000181791"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="302" mass="35072" checksum="D4B46F40FEC8E07E" modified="2017-01-18" version="1">MPLKELVSQFSFTRVLKSDSQTKTISILGKIDNKDAIVTIEKSHFNTGSDLDLQKLITELSLINSNDVYYWSTATLFQEVLELPGAKLNLIYPATETHIRKYDDQKLHYVRETPEMYQKYVIPYIETMKGDRLKWVYNILFEGKESETFVYHDKSPTGFVLLPDMKWDGKNLDTLYLCCIVNRLDISCVRDLNDSHIDYLTNLQKIVKEVTVNKYGIKPDQLRVFLHYQPSYYHFHLHIVNVQHPGLGDGIAIGKAILLDDAIDNLKLDGQYYTKKTIGFVLGENHGLWQIEGYRDLHFKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQT2</accession>
    <name>A0A1D8PQT2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">MRE11</name>
        <name evidence="22" type="ordered locus">CAALFM_C701340WA</name>
        <name evidence="21" type="ordered locus">orf19.6915</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712486.1">
        <property type="nucleotide sequence ID" value="XM_707393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQT2"/>
    <dbReference type="SMR" id="A0A1D8PQT2"/>
    <dbReference type="FunCoup" id="A0A1D8PQT2">
        <property type="interactions" value="1072"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQT2"/>
    <dbReference type="GeneID" id="3645898"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701340WA"/>
    <dbReference type="CGD" id="CAL0000182868">
        <property type="gene designation" value="MRE11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01340W_A"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQT2"/>
    <dbReference type="OMA" id="QNHTGHT"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010791">
        <property type="term" value="P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="375" mass="44503" checksum="410A244562608E14" modified="2017-01-18" version="1">MYTTNTLLDEKSFSLSQKYSIYHQPFTNTYQSNRYIYIIDKYFCKFIHNPIISSIILILSYTYYYYYYYYNNDNYDYDDYYLPQYLFVNDLVSNIINLICILRFQYRFKFNHLIGELIFFIGQSILSYQLIINQLLIHFNESTATTTTTTTTGTGTGTSTINCTLIIQWTIILQMILPIIILVFTYVDNYRNRNRNNDSNDNYTSGGLYSVIFEGNNHYIPVFLSYSFFLININLINANTTNTTTTTTTTSSSFSSTGSINTISNWFLELTFQQLIKFIYQLSCFSFKFYLMYQFILYELSINQIGFKKFINYQEFYPKLKEEDEEEEEEDKNAITTTTTRRLNIINFLKSDQFKNMLMILVCLIIIIIDIIQIK</sequence>
</entry>
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    <accession>A0A1D8PR37</accession>
    <name>A0A1D8PR37_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ordered locus">CAALFM_C702250WA</name>
        <name evidence="3" type="ordered locus">orf19.13841</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_716236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR37"/>
    <dbReference type="GeneID" id="3637003"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702250WA"/>
    <dbReference type="CGD" id="CAL0000178747">
        <property type="gene designation" value="orf19.13841"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02250W_A"/>
    <dbReference type="eggNOG" id="ENOG502SZ9T">
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    <dbReference type="OrthoDB" id="4096316at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
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        <property type="entry name" value="Rua1_C"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="411"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="569" mass="64180" checksum="BBA305DDF17256FB" modified="2017-01-18" version="1">MSYPIDNLMDISFPEELFPQSTFSRSLLDIVSYDLSENELKKTNESEENHQVNTSINPSLSSSLSTSSTSSSSSSSSSLSFQNELIHLLHEYSENTITISPSSATVSPKTYMNGYIKFVMDSANTSLEPIDTNETSTELTHEEVIELFEEACKEIDEWKPNNQKDNFNGCNNNNNNNNSNSDISVNDFGNSNCVNNNNIDANIDNSDNGENAISILPQSSSTFDPWNTIDFTSKFSMSHVTENRSTSVDSTKSDVQSQLSLNYPLKNLSNSNSNSNSNSESNLNSNLNSPIDIVSGSGSVSVSVNSSKTSSPRKRKLDNKNFYKVSKLDFSNLNIISIPDYEYSSQLSNHSFRVPNAYQCLILEEKLIESINNSTTCRVQRTLYTRDGLDKLARIYFHGDYEISINPNFKKTSYEAQYILTKLDKSRKPDNTTRAGLCPYCETIEFFGLKNSSYGNHLAYKHGILTNGCSVPDPKYYGKYKFKKGEYDEPEKKKRRTNAHILEREGVLCTNCWQILEVNCTSRSSVLGHYLRHYRDSHVGNKKEIKIDDEDPLAGFDPIVFEFTNKWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRR7</accession>
    <name>A0A1D8PRR7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">ACC1</name>
        <name evidence="22" type="ordered locus">CAALFM_CR00640WA</name>
        <name evidence="21" type="ordered locus">orf19.7466</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713531.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PRR7"/>
    <dbReference type="FunCoup" id="A0A1D8PRR7">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRR7"/>
    <dbReference type="GeneID" id="3639688"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00640WA"/>
    <dbReference type="CGD" id="CAL0000198598">
        <property type="gene designation" value="ACC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00640W_A"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRR7"/>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="98"/>
            <end position="607"/>
        </location>
    </feature>
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        <location>
            <begin position="256"/>
            <end position="448"/>
        </location>
    </feature>
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        <location>
            <begin position="734"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1527"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1865"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2210"/>
            <end position="2237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000198598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AOW30832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2271" mass="253422" checksum="D57D403C36D7A290" modified="2017-01-18" version="1">MRCKLSLIKNTNSLVHRSRFLITKPQLYIPHRHYIPFKNIFKSLLMSDQSPSPSPSDSLSYTTLHENLPSHFLGGNSVLNAEPSKVRDFVRAHQGHTVISKILIANNGIAAVKEIRSVRKWAYETFGDEKAIQFTVMATPEDLEANAEYIRMADQFIEVPGGTNNNNYANVDLIVEIAESTNAHAVWAGWGHASENPLLPEKLAASPKKIIFIGPPGSAMRSLGDKISSTIVAQHAQVPCIPWSGTGVDEVKIDPQTNLVSVADDIYAKGCCTSPEDGLEKAKKIGFPVMIKASEGGGGKGIRKVDDEKNFITLYNQAANEIPGSPIFIMKLAGDARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIARKETFHEMENAAVRLGKLVGYVSAGTVEYLYSHAEDKFYFLELNPRLQVEHPTTEMVTGVNLPAAQLQIAMGIPMHRIRDIRTLYGADPHTTTDIDFEFKSETSLVSQRRPTPKGHCTACRITSEDPGEGFKPSGGSLHELNFRSSSNVWGYFSVGNQSSIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETPDFEDNTITTGWLDELITKKLTAERPDPIVAVVCGAVTKVHIQAEEEKKEYIQSLEKGQVPHRNLLKTIFPVEFIYEGERYKFTATKSSEDKYTLFLNGSRCVVGARSLSDGGLLCALDGKSHSVYWKEEASATRLSVDGKTCLLEVENDPTQLRTPSPGKLVKYLVDSGEHVDAGQPYAEVEVMKMCMPLIAQENGVVQLIKQPGSTVNAGDILAILALDDPSKVKHAKPFEGTLPSMGEPNVTGTKPAHKFNHCAGILKNILAGYDNQVILNSTLKSLGEVLKDNELPYSEWQQQISALHSRLPPKLDDGLTALVERTQSRGAEFPARQILKLITKSIAENGNDMLEDVVAPLVSIATSYQNGLVEHEYDYFASLINEYYDVESLFSGENVREDNVILKLRDENKSDLKKVIGIGLSHSRVSAKNNLILAILDIYEPLLQSNSSVAASIREALKKLVQLDSRACAKVALKAREILIQCSLPSIKERSDQLEHILRSSVVQTSYGEIFAKHREPNLEIIREVVDSKHIVFDVLAQFLINPDPWVAIAAAEVYVRRSYRAYDLGKIEYHVNDRLPIVEWKFKLANMGAAGVNDAQQAAAAGGDDSTSMKHAASVSDLTFVVDSKTEHSTRTGVLAPARHLDDVDETLTAALEQFQPADAISFKAKGETPELLNVLNIVITSIDGYSDENEYLSRINEILCEYKEELISAGVRRVTFVFAHQIGQYPKYYTFTGPDYEENKVIRHIEPALAFQLELGRLANFDIKPIFTNNRNIHVYDAIGKNAPSDKRFFTRGIIRTGVLKEDISISEYLIAESNRLMNDILDTLEVIDTSNSDLNHIFINFSNAFNVQASDVEAAFGSFLERFGRRLWRLRVTGAEIRIVCTDPQGTSFPLRAIINNVSGYVVKSELYLEVKNPKGEWVFKSIGHPGSMHLRPISTPYPVKESLQPKRYKAHNMGTTYVYDFPELFRQATISQWKKYGKKVPKDVFVSLELITDETDSLIAVERDPGANKIGMVGFKVTAKTPEYPHGRQLIIVANDITHKIGSFGPEEDNYFNKCTELARKLGIPRIYLSANSGARIGVAEELIPLYQVAWNEEGSPDKGFRYLYLSTAAKESLEKDGKSDSVVTERIVEKGEERHVIKAIIGAEDGLGVECLKGSGLIAGATSRAYKDIFTITLVTCRSVGIGAYLVRLGQRAIQIDGQPIILTGAPAINKLLGREVYSSNLQLGGTQIMYNNGVSHLTANDDLAGVEKIMEWLSYVPAKRGLPVPILESEDSWDRDVDYYPPKQEAFDVRWMIQGREVDGEYESGLFDKDSFQETLSGWAKGVVVGRARLGGIPIGVIGVETRTVENLIPADPANPDSTESLIQEAGQVWYPNSAFKTAQAINDFNNGEQLPLMILANWRGFSGGQRDMYNEVLKYGSFIVDALVDFKQPIFTYIPPNGELRGGSWVVVDPTINSDMMEMYADVDSRAGVLEPEGMVGIKYRRDKLLATMERLDPTYGEMKAKLNDSSLSPEEHSKISAKLFAREKALLPIYAQISVQFADLHDRSGRMLAKGVIRKEIKWTDARRFFFWRLRRRLNEEYVLRLISEQIKDSSKLERVARLKSWMPTVEYDDDQAVSNWIEENHAKLQKRVNELKQEVSRTKIMRLLKEDPNSAISAMKDYVERLSKEDKEKFLKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSE7</accession>
    <name>A0A1D8PSE7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ifr2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">IFR2</name>
        <name evidence="3" type="ordered locus">CAALFM_CR03280WA</name>
        <name evidence="2" type="ordered locus">orf19.9932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713229.2">
        <property type="nucleotide sequence ID" value="XM_708136.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSE7"/>
    <dbReference type="SMR" id="A0A1D8PSE7"/>
    <dbReference type="FunCoup" id="A0A1D8PSE7">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSE7"/>
    <dbReference type="GeneID" id="3645100"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03280WA"/>
    <dbReference type="CGD" id="CAL0000187722">
        <property type="gene designation" value="IFR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03280W_A"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSE7"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001398">
        <property type="entry name" value="Zinc-binding oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000187722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="358" mass="38492" checksum="E8E1C3F27443359F" modified="2017-01-18" version="1">MKAAVVPESVTETKLAEVKEIPKPTIGDDQILIKAEAAAVNPTDWKHIVFQMSKPGDVIGSDVSGTVEEVGSKVTNFKKGDTVSSFIIGNISPDSGAFGEYVIAYPQATIKYDHSLSHSSATNSSTIKSYEGAASVTLGLSTIGISFSHYLNIGKHKKEGDSILIWGGATATGILAIQVAKLVYNLNVITTASPKNHAFLKELGADHTLDYNDPNVIENLKALGPIKFGLDTIANTTTFQGLYDATAGTPEVYLDSLLGLDGKSIKTDPSRENSVHWGYTLAYLCVIKEKSFGPTKFVQTPELVDDYLKWWNEVLPTFIGKIKHANLKILGDGLASANEALQLSRDSKVSAQKIVFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSW4</accession>
    <name>A0A1D8PSW4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Crossover junction endodeoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_CR05010WA</name>
        <name evidence="4" type="ordered locus">orf19.8267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="CGD" id="CAL0000180624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="300" mass="32534" checksum="79177D625BACD9FA" modified="2017-01-18" version="1">MSSEVPGKPMKIAGGGNHTMVILDNGEVFTCGSNEFGQCGLPRGESLGVFHKVPGNDWLDISCGWEFSILVKRSGEVYVCGRGLKGELGLGKETPESELIYSTTVDGFKEIKSCMQHTIIQTTNGLVGWGNSRKGQLGETEDKIMWTPKTLRFGVVCKDFSLGREFTAIQTDTNRVKIFGKSSIKNIPESTVARVAAMWSSVHILSETNVLQSFGNNSHEQLFPNNSSVAVEEYAIGSEHGLVTSDNIVYAWGWSEHGNCGTSNASDKVTFDYLNKLYTGSAKVVLIGAGCATSWVVVEK</sequence>
</entry>
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    <accession>A0A1D8PU10</accession>
    <name>A0A1D8PU10_CANAL</name>
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        <submittedName>
            <fullName evidence="4">Nuo1p</fullName>
        </submittedName>
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    <gene>
        <name evidence="3 4" type="primary">NUO1</name>
        <name evidence="4" type="ordered locus">CAALFM_CR09550CA</name>
        <name evidence="3" type="ordered locus">orf19.6607</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711306.1">
        <property type="nucleotide sequence ID" value="XM_706214.1"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR09550CA"/>
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    </dbReference>
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        <location>
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            <end position="106"/>
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    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="115"/>
            <end position="203"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000193252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="204" mass="23915" checksum="032585461633630A" modified="2017-01-18" version="1">MSYTATNQPVRAPPLNSDYELIDGDPYFTRVVSYFRFSDYVNWAVITASFPLGMKLWEKIVPSQGKGLKPSVVNPVTLRVSTLLGFFGGFCLNYVKSSQRFLGWRENSREVKLDRFEIKQKLSQGVLPYNEHLSKLDDRNKDISNRNSQYSHALLFVIPWFNTTYHPYHQVDLKKYYINREGEENWGFELKPLDEIYAKYGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU33</accession>
    <name>A0A1D8PU33_CANAL</name>
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        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
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    <gene>
        <name evidence="11 12" type="primary">SPT7</name>
        <name evidence="12" type="ordered locus">CAALFM_CR09980WA</name>
        <name evidence="11" type="ordered locus">orf19.7572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719334.1">
        <property type="nucleotide sequence ID" value="XM_714241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU33"/>
    <dbReference type="SMR" id="A0A1D8PU33"/>
    <dbReference type="FunCoup" id="A0A1D8PU33">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU33"/>
    <dbReference type="GeneID" id="3638928"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09980WA"/>
    <dbReference type="CGD" id="CAL0000181512">
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    <dbReference type="VEuPathDB" id="FungiDB:CR_09980W_A"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="YRRSEAK"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="428"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1224"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000181512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1307" mass="149239" checksum="02D97913B9E886D4" modified="2017-01-18" version="1">MDKLETFQRNDPRKLFELANQLNERSFFAIFLNETQFKIINHILSLDNFEIWTNFLEGNCYISYLQPEDKNDKPETPNTNENNESAGGERIQNNSSDRDTPTLNNNDKKNDSNKETMQAELETPETLFPEGAEMIKKLALHVRYLLWEKAIDFYYNSKVLDESNNILDEVSDDYQLIDSLDNIVDEKASNESEKKEAVEKLKVREIEDDYDDDDEDEDEDEDNNDKPNTTDLANNNSNSSESRLAYNSNEQLVLEIPLSIFKTKQQETNGTQDRISNSLSADGNSSSNNFGVIKQLEENNNEDQDKLLQEFNKVYHNFEYDRETLLKRRKLEKSDMQLESNKSNKGDNASDSKSATHIDMNLGAASTSLQHLLSTIQSKRNKVPLNDHELRTLFMDVRKNRGKWANDDRVGQEELYEACEKVVTELRGYTEHSTFFLNKVSKREAPNYGLIIKKPMDLNTVLKKLKNLAYNSKQEFVDDLMLIWSNCLTYNADPAHFIRAHAIAMQKKTIKLIPTIPDIRIRNRAEVEKEEEVENGKRDEEEDSLGGKSMKKGRKRSRQDEIKAEAEAETPNSPSPAGTPFLASEVNSVRENTPAATDNGNVSNDEEEEEEEDTDNINGTATGISGMVDGDDEEFDPELQAWRTLTAKSRANYCAQRADLFDENGHLKSDVPAICRKSNEMSNFNEYLNNKEVISKSKSLLENDEPYLLEYDVAGGIPGIAYCGVDKETEETYENKLVDIYLQQTSGDASKIKSDFVLSTNSGLNKVYFENICEIQEIRKICFKISLIRQMQTQQFVHHTQMKQPEIQTLKEIDVDAASKLPNHDASTGDVQFSVFRRNIAKIAMQTGFETTQQAAINTLTQVAERYLGNLIKSLKLHSETTSDNRLPPREILLLSLLENGVDRPDDLYTFVQERVVKQQGKLKDLRIKLSNFLKDLLRPGLENFNEKSFEDNSEQFMTGDFSNGIGDDFFGFKELGLDKEFKMLTSSIPIYLLHSRLHNQFTTGGGTAQRNKYEDLQEYEPDKIHGNEVDKQIGILISFYQTLYEKSQTFYVKAQKKKGESMELPPDNIFILTEDEDLPQKQRNVRPKLPPTGRISSIKKKIIANSFFLPEEEELQKQEMELKAKEEAEAAAAAAAAAANSTQTAETAQVMKPVDSLEMSETLNTSDIADMLREIESANAPVSREEQLPEKQFNTEEKKVGLPKTDANELKYEPVDEQSKIYATTEKNDNVKGIENKPKQEDFKQIENNQENKNLEEIEDTLEDDTEIENSDSTKLDIKENETLVYESEVDPDESSIDSLFEQNEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-08-01" modified="2025-06-18" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>P22274</accession>
    <accession>A0A1D8PTU0</accession>
    <accession>Q5A316</accession>
    <name>ARF_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ARF1</name>
        <name type="ordered locus">CAALFM_CR08700CA</name>
        <name type="ORF">CaO19.13805</name>
        <name type="ORF">CaO19.6447</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Gene" volume="110" first="123" last="128">
            <title>Cloning and characterization of the gene encoding the ADP-ribosylation factor in Candida albicans.</title>
            <authorList>
                <person name="Denich K."/>
                <person name="Malloy P.J."/>
                <person name="Feldman D."/>
            </authorList>
            <dbReference type="PubMed" id="1544569"/>
            <dbReference type="DOI" id="10.1016/0378-1119(92)90455-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Biol. Chem." volume="267" first="17159" last="17169">
            <title>4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I.</title>
            <authorList>
                <person name="Langner C.A."/>
                <person name="Lodge J.K."/>
                <person name="Travis S.J."/>
                <person name="Caldwell J.E."/>
                <person name="Lu T."/>
                <person name="Li Q."/>
                <person name="Bryant M.L."/>
                <person name="Devadas B."/>
                <person name="Gokel G.W."/>
                <person name="Kobayashi G.S."/>
            </authorList>
            <dbReference type="PubMed" id="1512254"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="M54910">
        <property type="protein sequence ID" value="AAA64266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="S43354">
        <property type="protein sequence ID" value="AAB23053.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JH0260">
        <property type="entry name" value="JH0260"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716284.1">
        <property type="nucleotide sequence ID" value="XM_711191.1"/>
    </dbReference>
    <dbReference type="PDB" id="6PTA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D=1-179"/>
    </dbReference>
    <dbReference type="PDBsum" id="6PTA"/>
    <dbReference type="AlphaFoldDB" id="P22274"/>
    <dbReference type="SMR" id="P22274"/>
    <dbReference type="FunCoup" id="P22274">
        <property type="interactions" value="1220"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P22274"/>
    <dbReference type="EnsemblFungi" id="CR_08700C_A-T">
        <property type="protein sequence ID" value="CR_08700C_A-T-p1"/>
        <property type="gene ID" value="CR_08700C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642130"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08700CA"/>
    <dbReference type="CGD" id="CAL0000186453">
        <property type="gene designation" value="ARF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08700C_A"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="P22274"/>
    <dbReference type="OMA" id="IRQRHWF"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PRO" id="PR:P22274"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0519">Myristate</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000207412" description="ADP-ribosylation factor">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA64266." evidence="2" ref="1">
        <original>R</original>
        <variation>M</variation>
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="19"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="61"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="78"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="85"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="136"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="153"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="6PTA"/>
        </source>
    </evidence>
    <sequence length="179" mass="20258" checksum="BBB1949760975202" modified="2017-03-15" version="5">MGLTISKLFASLLGRREMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRYYFQNTQGIIFVVDSNDRDRINEAREELQSMLNEDELKDAVLLVLANKQDLPNAMNAAEITEKMGLHSIRNRPWFIQATCATTGDGLYEGLEWLSNQVGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-07-01" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>P31353</accession>
    <accession>A0A1D8PCR5</accession>
    <accession>Q5AIB6</accession>
    <name>PMM_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Phosphomannomutase</fullName>
            <shortName>PMM</shortName>
            <ecNumber evidence="5">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PMM1</name>
        <name type="ordered locus">CAALFM_C102480WA</name>
        <name type="ORF">CaO19.10454</name>
        <name type="ORF">CaO19.2937</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Curr. Genet." volume="22" first="501" last="503">
            <title>The Candida albicans PMM1 gene encoding phosphomannomutase complements a Saccharomyces cerevisiae sec 53-6 mutation.</title>
            <authorList>
                <person name="Smith D.J."/>
                <person name="Cooper M."/>
                <person name="De Tiani M."/>
                <person name="Losberger C."/>
                <person name="Payton M.A."/>
            </authorList>
            <dbReference type="PubMed" id="1473182"/>
            <dbReference type="DOI" id="10.1007/BF00326416"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="submission" date="2016-12" db="PDB data bank">
            <title>Crystal structure of the phosphomannomutase PMM1 from Candida albicans, apoenzyme state.</title>
            <authorList>
                <person name="Stogios P.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH MAGNESIUM IONS</scope>
    </reference>
    <comment type="function">
        <text>Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic PMM family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW25932.1"/>
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        <property type="nucleotide sequence ID" value="XM_716343.1"/>
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        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B=1-252"/>
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        <property type="gene ID" value="C1_02480W_A"/>
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    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
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        <property type="reaction ID" value="UER00424"/>
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        <property type="component" value="Chromosome 1"/>
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    <keyword id="KW-0002">3D-structure</keyword>
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    <keyword id="KW-0460">Magnesium</keyword>
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        </source>
    </evidence>
    <sequence length="252" mass="29019" checksum="25455FC315D85212" modified="1993-07-01" version="1">MSFANKQDPKTLVLFDVDGTLTPARLTISEEMKKTLEKLREKVVIGFVGGSDLSKQVEQLGPNVLNDFDYCFSENGLTAYKLGKELASQSFINWIGNEKYNKLVKFILRYLSDIDLPIRRGTFIEFRNGMINVSPIGRNASTQERNDYEKFDKQHHIRETMVEALKKEFPDFGLTYSIGGQISFDVFPTGWDKTYCLQHVEDEHFENIHFFGDKSYKGGNDYEIYNDPRTIGHAVNSPDDTIRILNETFKLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>P40954</accession>
    <accession>A0A1D8PU43</accession>
    <accession>Q5ACQ6</accession>
    <name>CHI3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Chitinase 3</fullName>
            <ecNumber>3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CHT3</name>
        <name type="ordered locus">CAALFM_CR10110WA</name>
        <name type="ORF">CaO19.7586</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Proc. Natl. Acad. Sci. U.S.A." volume="92" first="2544" last="2548">
            <title>Molecular cloning and characterization of chitinase genes from Candida albicans.</title>
            <authorList>
                <person name="McCreath K.J."/>
                <person name="Specht C.A."/>
                <person name="Robbins P.W."/>
            </authorList>
            <dbReference type="PubMed" id="7708682"/>
            <dbReference type="DOI" id="10.1073/pnas.92.7.2544"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC 10261 / CBS 2718 / NBRC 1061</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="969" last="983">
            <title>The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence.</title>
            <authorList>
                <person name="Kelly M.T."/>
                <person name="MacCallum D.M."/>
                <person name="Clancy S.D."/>
                <person name="Odds F.C."/>
                <person name="Brown A.J."/>
                <person name="Butler G."/>
            </authorList>
            <dbReference type="PubMed" id="15255906"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04185.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Fungal Genet. Biol." volume="42" first="935" last="947">
            <title>Candida albicans CHT3 encodes the functional homolog of the Cts1 chitinase of Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Dunkler A."/>
                <person name="Walther A."/>
                <person name="Specht C.A."/>
                <person name="Wendland J."/>
            </authorList>
            <dbReference type="PubMed" id="16214381"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2005.08.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2010" name="Jpn. J. Infect. Dis." volume="63" first="355" last="357">
            <title>Micafungin alters the expression of genes related to cell wall integrity in Candida albicans biofilms.</title>
            <authorList>
                <person name="Kaneko Y."/>
                <person name="Ohno H."/>
                <person name="Kohno S."/>
                <person name="Miyazaki Y."/>
            </authorList>
            <dbReference type="PubMed" id="20859005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2010" name="Yeast" volume="27" first="661" last="672">
            <title>Mass spectrometric analysis of the secretome of Candida albicans.</title>
            <authorList>
                <person name="Sorgo A.G."/>
                <person name="Heilmann C.J."/>
                <person name="Dekker H.L."/>
                <person name="Brul S."/>
                <person name="de Koster C.G."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="20641015"/>
            <dbReference type="DOI" id="10.1002/yea.1775"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 7 8">Expression is positively regulated by ACE2. Transcription is greater during growth of the yeast form as compared to the mycelial form, and down-regulated by micafungin treatment.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to strong decrease of secreted chitinase activity, as well as to the clumping or clusterings of cells from early exponential phase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14"/>
    <dbReference type="EMBL" id="U15801">
        <property type="protein sequence ID" value="AAA68016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719348.1">
        <property type="nucleotide sequence ID" value="XM_714255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40954"/>
    <dbReference type="SMR" id="P40954"/>
    <dbReference type="FunCoup" id="P40954">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P40954"/>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="P40954">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CR_10110W_A-T">
        <property type="protein sequence ID" value="CR_10110W_A-T-p1"/>
        <property type="gene ID" value="CR_10110W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638967"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10110WA"/>
    <dbReference type="CGD" id="CAL0000194074">
        <property type="gene designation" value="CHT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10110W_A"/>
    <dbReference type="eggNOG" id="KOG4701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007818_7_0_1"/>
    <dbReference type="InParanoid" id="P40954"/>
    <dbReference type="OMA" id="GTTCFAY"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000125">
        <property type="entry name" value="CTS1p Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0146">Chitin degradation</keyword>
    <keyword id="KW-0147">Chitin-binding</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000011926" description="Chitinase 3">
        <location>
            <begin position="17"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15255906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16214381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="20641015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="20859005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="7708682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="567" mass="60061" checksum="DD843126F65E22C2" modified="1995-11-01" version="2" precursor="true">MLYLLTIFSLLLPALAINARSNSNVAVYWGQNSGGSQQRLSYYCDSDAVDIVILSFMHQFPSPIQLNFANACEGTYTANGILQCQTIAEDIKYCQNKGKTILLSLGGAAGSYGFSDDATAKQFAHTLWDLFGNSKNLATNDRPFYDAVLDGFDFDIENNWSTGYPALATELRTLFQKDTSKNYYLGAAPQCPYPDASVGPLLKQSEIDFVFIQFYNNYCNLGSSSFNWDTWLNYAETDSPNKNIKLFVGVPASSRAAGSGYNDPSAVSQYLTSDILNSKYFGGISMWDVSAGWSNTNSNGNFVENMKAIVKKASPGEETTSSSTTTTTTTTSTTISSSSSSSKTSKTSTTSTTSSSISSTTSSTTSSTSSSSTSSSTSSTTSSSTTSSQISTTSTAPTSSTSLSSSTISTSASTSDTTSVTSSETTPVVTPSSLSSAITIPGDSTTTGISKSSSTKPATSTTSALSSSTTTVATIPDDKEIINTPTDTETTSKPPAIITESDATTITQNLTPSTTTKNVKTTSTNIVTEWVWAPTTLRTLTTTYQILTTRTHIETVFAEPSTVVIYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>P87163</accession>
    <accession>A0A1D8PEB7</accession>
    <accession>Q59QB1</accession>
    <name>EI2BE_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>GCD complex subunit GCD6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Guanine nucleotide exchange factor subunit GCD6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GCD6</name>
        <name type="synonym">TIF225</name>
        <name type="ordered locus">CAALFM_C108600CA</name>
        <name type="ORF">CaO19.407</name>
        <name type="ORF">CaO19.8037</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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    <reference key="4">
        <citation type="journal article" date="1997" name="Gene" volume="189" first="119" last="126">
            <title>Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Favre B."/>
                <person name="Ryder N.S."/>
            </authorList>
            <dbReference type="PubMed" id="9161422"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(96)00844-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 544-732</scope>
        <source>
            <strain>SFI-0124</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AAC49714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_706802.2"/>
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        <property type="protein sequence ID" value="C1_08600C_A-T-p1"/>
        <property type="gene ID" value="C1_08600C_A"/>
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    <dbReference type="GeneID" id="3646510"/>
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        <property type="gene designation" value="GCD6"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000250"/>
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
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        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
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        <property type="entry name" value="LbH_eIF2B_epsilon"/>
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        <property type="entry name" value="W2_eIF2B_epsilon"/>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="eIF-2B_epsilon_N"/>
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        <property type="entry name" value="eIF2B_epsilon"/>
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        <property type="entry name" value="LbH_EIF2B3/5"/>
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        <property type="entry name" value="NTP_transferase_dom"/>
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    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
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        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
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    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="732"/>
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    <feature type="domain" description="W2" evidence="2">
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            <begin position="559"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
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    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="732" mass="81952" checksum="A7C2E826A30376BB" modified="2017-03-15" version="3">MAPKSKKQAATQSKSKKSKDLVDERFQAIVLTDSFETRFMPLTAVHPRCLLPLANVPLIEYTLEFLANAGVNEVYLMCSAHADQIQEYIENSKWMGDNSPFSVTTIMSIESRSVGDTMRDLDNRGLIAGDFLLVSGDVVTNMDFSKALQFHKQKKAQDKDHIATMVLNQASPLHRTRSQIDPAAFVLDKETNRCIFYQSIPPVSGKKTCISIDPELLEDFQGELQVRNDLIDCHVDICSPHVPQIFQENFDYQYLRSDFLKGVLTSDLLKKTIYAYISKDSSEYAARVESWSTYDAISQDILARWCYPLVPDSNLVEGNSYSYELNNIYKEDKIILAQSCKIGTSTSIGRNSSVGEGTQIKNSVIGRNCTIGKNVVIENSYIWDNAVIKDNSVLNRSIVAADAQIGNNVTLSPGSVIGFNVIIGDDKVIPHNVKIVETPIVTENEFGDFDDESNSEDENEYEDGNAVPVLAVKDVELVGETGKGFAYESEIESGDEDDEEFVGNGTYSGIIYQMKSLNVSDDSIASVSNKKVKKHSHRRRLSMNSMISDNGGAFESDEGEEEEDFGVEGLATVTRAIENNHDIDTALLELNTLRMSMNVTYHDVRSVTTQALVNKIVDFITTGTLTPQEAATKIFTKWGIMFKRQVFSPEEEVDLLNIVEEKSSVLDKAYNQIVLFLGVKSFYDMEVVEEENILKWWNDGENDEVRTLAAKFITWLQEADEEDSDEDDEDSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q07730</accession>
    <accession>A0A1D8PLT9</accession>
    <accession>Q59PG4</accession>
    <name>CECE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="38">Extent of cell elongation protein 1</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="37">ECE1-I</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="37">ECE1-II</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="37">Candidalysin ECE1-III</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="37">ECE1-IV</fullName>
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        </component>
        <component>
            <recommendedName>
                <fullName evidence="37">ECE1-V</fullName>
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        </component>
        <component>
            <recommendedName>
                <fullName evidence="37">ECE1-VI</fullName>
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        </component>
        <component>
            <recommendedName>
                <fullName evidence="37">ECE1-VII</fullName>
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        </component>
        <component>
            <recommendedName>
                <fullName evidence="37">ECE1-VIII</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="38" type="primary">ECE1</name>
        <name type="ordered locus">CAALFM_C403470CA</name>
        <name type="ORF">CaO19.10882</name>
        <name type="ORF">CaO19.3374</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Infect. Immun." volume="61" first="3648" last="3655">
            <title>Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans.</title>
            <authorList>
                <person name="Birse C.E."/>
                <person name="Irwin M.Y."/>
                <person name="Fonzi W.A."/>
                <person name="Sypherd P.S."/>
            </authorList>
            <dbReference type="PubMed" id="8359888"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="PLoS Pathog." volume="2" first="E63" last="E63">
            <title>Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Andes D.R."/>
                <person name="Nett J.E."/>
                <person name="Smith F.J."/>
                <person name="Yue F."/>
                <person name="Phan Q.T."/>
                <person name="Edwards J.E."/>
                <person name="Filler S.G."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="16839200"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.0020063"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="5273" last="5279">
            <title>HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1.</title>
            <authorList>
                <person name="Sharkey L.L."/>
                <person name="McNemar M.D."/>
                <person name="Saporito-Irwin S.M."/>
                <person name="Sypherd P.S."/>
                <person name="Fonzi W.A."/>
            </authorList>
            <dbReference type="PubMed" id="10464197"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2000" name="Genetics" volume="155" first="57" last="67">
            <title>TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans.</title>
            <authorList>
                <person name="Braun B.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="10790384"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="EMBO J." volume="20" first="4742" last="4752">
            <title>NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans.</title>
            <authorList>
                <person name="Murad A.M."/>
                <person name="Leng P."/>
                <person name="Straffon M."/>
                <person name="Wishart J."/>
                <person name="Macaskill S."/>
                <person name="MacCallum D."/>
                <person name="Schnell N."/>
                <person name="Talibi D."/>
                <person name="Marechal D."/>
                <person name="Tekaia F."/>
                <person name="d'Enfert C."/>
                <person name="Gaillardin C."/>
                <person name="Odds F.C."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="11532938"/>
            <dbReference type="DOI" id="10.1093/emboj/20.17.4742"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2903" last="2912">
            <title>Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis.</title>
            <authorList>
                <person name="Kadosh D."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="15814840"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-01-0073"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2008" name="BMC Microbiol." volume="8" first="116" last="116">
            <title>Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris.</title>
            <authorList>
                <person name="Bader O."/>
                <person name="Krauke Y."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="18625069"/>
            <dbReference type="DOI" id="10.1186/1471-2180-8-116"/>
        </citation>
        <scope>CLEAVAGE BY KEX2</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2013" name="Mol. Microbiol." volume="87" first="132" last="151">
            <title>A family of secreted pathogenesis-related proteins in Candida albicans.</title>
            <authorList>
                <person name="Rohm M."/>
                <person name="Lindemann E."/>
                <person name="Hiller E."/>
                <person name="Ermert D."/>
                <person name="Lemuth K."/>
                <person name="Trkulja D."/>
                <person name="Sogukpinar O."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
                <person name="Urban C.F."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="23136884"/>
            <dbReference type="DOI" id="10.1111/mmi.12087"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
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        <citation type="journal article" date="2023" name="Int. Immunopharmacol." volume="119" first="110195" last="110195">
            <title>Candidalysin amplifies the immune inflammatory response in Candida albicans keratitis through the TREM-1/DAP12 pathway.</title>
            <authorList>
                <person name="Hu L."/>
                <person name="Bai G."/>
                <person name="Xu Q."/>
                <person name="Zhao G."/>
                <person name="Jiang N."/>
                <person name="Yao H."/>
                <person name="Liu X."/>
                <person name="Du Z."/>
            </authorList>
            <dbReference type="PubMed" id="37087869"/>
            <dbReference type="DOI" id="10.1016/j.intimp.2023.110195"/>
        </citation>
        <scope>FUNCTION (CANDIDALYSIN ECE1-III)</scope>
    </reference>
    <reference key="37">
        <citation type="journal article" date="2023" name="Int. J. Mol. Sci." volume="24" first="0" last="0">
            <title>Effects of candidalysin derived from Candida albicans on the expression of pro-inflammatory mediators in human gingival fibroblasts.</title>
            <authorList>
                <person name="Nishikawa Y."/>
                <person name="Tomotake Y."/>
                <person name="Kawano H."/>
                <person name="Naruishi K."/>
                <person name="Kido J.I."/>
                <person name="Hiroshima Y."/>
                <person name="Murakami A."/>
                <person name="Ichikawa T."/>
                <person name="Yumoto H."/>
            </authorList>
            <dbReference type="PubMed" id="36834667"/>
            <dbReference type="DOI" id="10.3390/ijms24043256"/>
        </citation>
        <scope>FUNCTION (CANDIDALYSIN ECE1-III)</scope>
    </reference>
    <reference key="38">
        <citation type="journal article" date="2023" name="Microbiol. Spectr." volume="11" first="e0025323" last="e0025323">
            <title>Functional analysis of the Candida albicans ECE1 Promoter.</title>
            <authorList>
                <person name="Garbe E."/>
                <person name="Thielemann N."/>
                <person name="Hohner S."/>
                <person name="Kumar A."/>
                <person name="Vylkova S."/>
                <person name="Kurzai O."/>
                <person name="Martin R."/>
            </authorList>
            <dbReference type="PubMed" id="36786567"/>
            <dbReference type="DOI" id="10.1128/spectrum.00253-23"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 10 14">Secreted protein cleaved by KEX2 in 8 similar peptides (ECE1-I to ECE1-VIII) (PubMed:27027296, PubMed:29362237). Stimulates biofilm formation (PubMed:16839200).</text>
    </comment>
    <comment type="function">
        <molecule>Candidalysin ECE1-III</molecule>
        <text evidence="10 12 13 14 15 16 17 18 19 20 21 23 24 25 26 27 28 29 30 31 32 34 35">Acts as a cytolytic peptide toxin that directly damages host epithelial membranes, triggers a danger response signaling pathway and activates epithelial immunity (PubMed:27027296, PubMed:29101209, PubMed:29109176, PubMed:29362237, PubMed:29871918, PubMed:30622184, PubMed:31127085, PubMed:31401652, PubMed:33038250, PubMed:34245079, PubMed:35073742). Polymerizes in solution to form membrane pores to damage epithelial cells (PubMed:36173096). Induces calcium influx, oxidative stress, mitochondrial dysfunction and ATP depletion in host cells, leading to epithelial necrosis (PubMed:27027296, PubMed:34085369). Serves as a danger signal that potentiates the immune response, and more specifically IL-17 response (PubMed:29101209). Induces cytokine/chemokine secretion by host (especially CCL2/3/4, CXCL1 and S100A8), neutrophil recruitment, and promotes mortality in zebrafish and murine models of systemic fungal infection (PubMed:29109176, PubMed:31401652). Mediates distinct epithelial inflammatory responses through p38, EGFR-ERK and TREM-1/DAP12 pathways (PubMed:29109176, PubMed:35380879, PubMed:36037968, PubMed:36834667, PubMed:37087869). Acts as one of the hypha-derived drivers of NLRP3 inflammasome responses in primary macrophages and thus contributes to the capacity to induce maturation and secretion of IL-1beta from primary macrophages (PubMed:30323213, PubMed:30622184). Stimulates mast cells by mediating cross-talk between signaling pathways activated by the dectin-1 receptor and MAPKs (PubMed:35420364). Enables escape via the gasdermin-mediated pyroptosis, as well as a cell lysis pathway associated with macrophage extracellular trap formation termed ETosis (PubMed:36130496). Acts as the main hemolytic factor of C.albicans (PubMed:36548771). As an exotoxine, also promotes alcohol-associated liver disease or oral carcinogenesis (PubMed:31606552, PubMed:32170981).</text>
    </comment>
    <comment type="subunit">
        <molecule>Candidalysin ECE1-III</molecule>
        <text evidence="31">Polymerizes in solution to form membrane pores.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-64052688">
            <id>PRO_0000436401</id>
        </interactant>
        <interactant intactId="EBI-741406">
            <id>P51946</id>
            <label>CCNH</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-64052307">
            <id>PRO_0000436402</id>
        </interactant>
        <interactant intactId="EBI-741406">
            <id>P51946</id>
            <label>CCNH</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-64052752">
            <id>PRO_0000436403</id>
        </interactant>
        <interactant intactId="EBI-741406">
            <id>P51946</id>
            <label>CCNH</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-64052787">
            <id>PRO_0000436404</id>
        </interactant>
        <interactant intactId="EBI-741406">
            <id>P51946</id>
            <label>CCNH</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Candidalysin ECE1-III</molecule>
        <subcellularLocation>
            <location evidence="10">Host cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="25">Candidalysin is delivered to the invasion pocket in which the hypha is tightly surrounded by the host membrane, to enable the full damage potential of during mucosal infection.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="36">Expressed in elongating hyphae but not in budding yeast cells (PubMed:8359888).</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3 4 5 6 9 11 22 33">Expression is induced by human serum and epithelial cells (PubMed:24673895). Expression is regulated by the transcription factors EFG1, BCR1, TUP1, RFG1, NRG1 and AHR1 (PubMed:10464197, PubMed:10790384, PubMed:11532938, PubMed:15814840, PubMed:16839200, PubMed:32345638). Expression is down-regulated by minocycline (PubMed:28367877). Expression is controlled by a very long promoter of at minimum 1500 bp allowing a complex network of transcription factors to contribute to the gene's regulation (PubMed:36786567).</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal alpha-helix of peptide ECE1-III allows insertion of the toxin into host epithelial cells membranes (PubMed:27027296).</text>
    </comment>
    <comment type="PTM">
        <text evidence="7 10">Cleavage by KEX2 generates 8 peptides ECE1-I to ECE1-VIII, all terminating in Lys-Arg (PubMed:18625069, PubMed:27027296). Only peptide ECE1-III, called candidalysin, shows toxin activity (PubMed:27027296).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="10 12 19 28">Impairs damaging of epithelia and induction of p-MKP1/c-Fos-mediated danger responses and cytokine secretion (PubMed:27027296). Elicits a blunted type 17 immune response (PubMed:29101209). Induced significantly decreased levels of cytokine/chemokine secretion by host (PubMed:31401652). Fails to induce host mast cells activation (PubMed:35420364).</text>
    </comment>
    <dbReference type="EMBL" id="L17087">
        <property type="protein sequence ID" value="AAA34338.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711594.1">
        <property type="nucleotide sequence ID" value="XM_706502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q07730"/>
    <dbReference type="SMR" id="Q07730"/>
    <dbReference type="IntAct" id="Q07730">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q07730"/>
    <dbReference type="TCDB" id="1.C.139.1.1">
        <property type="family name" value="the candidalysin (cl) family"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_03470C_A-T">
        <property type="protein sequence ID" value="C4_03470C_A-T-p1"/>
        <property type="gene ID" value="C4_03470C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646814"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403470CA"/>
    <dbReference type="CGD" id="CAL0000199701">
        <property type="gene designation" value="ECE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03470C_A"/>
    <dbReference type="HOGENOM" id="CLU_1019397_0_0_1"/>
    <dbReference type="InParanoid" id="Q07730"/>
    <dbReference type="OMA" id="HAPEFNM"/>
    <dbReference type="OrthoDB" id="4024249at2759"/>
    <dbReference type="PHI-base" id="PHI:11814"/>
    <dbReference type="PHI-base" id="PHI:123053"/>
    <dbReference type="PHI-base" id="PHI:123207"/>
    <dbReference type="PHI-base" id="PHI:123274"/>
    <dbReference type="PHI-base" id="PHI:7644"/>
    <dbReference type="PHI-base" id="PHI:7759"/>
    <dbReference type="PHI-base" id="PHI:7895"/>
    <dbReference type="PHI-base" id="PHI:8546"/>
    <dbReference type="PHI-base" id="PHI:8787"/>
    <dbReference type="PHI-base" id="PHI:9404"/>
    <dbReference type="PHI-base" id="PHI:9442"/>
    <dbReference type="PHI-base" id="PHI:9679"/>
    <dbReference type="PRO" id="PR:Q07730"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140912">
        <property type="term" value="F:membrane destabilizing activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044179">
        <property type="term" value="P:hemolysis in another organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009609">
        <property type="term" value="P:response to symbiotic bacterium"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001897">
        <property type="term" value="P:symbiont-mediated cytolysis of host cell"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141139">
        <property type="term" value="P:symbiont-mediated disruption of host mucosa"/>
        <property type="evidence" value="ECO:0000269"/>
        <property type="project" value="SigSci"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1032">Host cell membrane</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0800">Toxin</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000086910" description="ECE1-I" evidence="39">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436401" description="ECE1-II" evidence="39">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436402" description="Candidalysin ECE1-III" evidence="39">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436403" description="ECE1-IV" evidence="39">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436404" description="ECE1-V" evidence="39">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436405" description="ECE1-VI" evidence="39">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436406" description="ECE1-VII" evidence="39">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436407" description="ECE1-VIII" evidence="39">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impairs secretion of candidalysin and subsequent induction of epithelial damage and inflammatory responses in vitro, and leads to attenuated virulence in vivo in a murine model of oropharyngeal candidiasis." evidence="14">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impairs polymerization of candidalysin ECE1-III and subsequent pore formation in synthetic lipid systems, and fails to activate the danger response pathway." evidence="31">
        <original>G</original>
        <variation>W</variation>
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impairs secretion of candidalysin and subsequent induction of epithelial damage and inflammatory responses in vitro, and leads to attenuated virulence in vivo in a murine model of oropharyngeal candidiasis." evidence="14">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="10464197"/>
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    </evidence>
    <evidence type="ECO:0000269" key="3">
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            <dbReference type="PubMed" id="10790384"/>
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        <source>
            <dbReference type="PubMed" id="15814840"/>
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            <dbReference type="PubMed" id="29101209"/>
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            <dbReference type="PubMed" id="32345638"/>
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        <source>
            <dbReference type="PubMed" id="33038250"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="34085369"/>
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    </evidence>
    <evidence type="ECO:0000269" key="25">
        <source>
            <dbReference type="PubMed" id="34245079"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="35073742"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="35420364"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="36037968"/>
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        <source>
            <dbReference type="PubMed" id="36130496"/>
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        <source>
            <dbReference type="PubMed" id="36173096"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="36548771"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="36786567"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="36834667"/>
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    </evidence>
    <evidence type="ECO:0000269" key="35">
        <source>
            <dbReference type="PubMed" id="37087869"/>
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    </evidence>
    <evidence type="ECO:0000269" key="36">
        <source>
            <dbReference type="PubMed" id="8359888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="37">
        <source>
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    </evidence>
    <evidence type="ECO:0000303" key="38">
        <source>
            <dbReference type="PubMed" id="8359888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="39">
        <source>
            <dbReference type="PubMed" id="27027296"/>
        </source>
    </evidence>
    <sequence length="271" mass="28878" checksum="2AF8DF50498EF230" modified="1995-11-01" version="2" precursor="true">MKFSKIACATVFALSSQAAIIHHAPEFNMKRDVAPAAPAAPADQAPTVPAPQEFNTAITKRSIIGIIMGILGNIPQVIQIIMSIVKAFKGNKREDIDSVVAGIIADMPFVVRAVDTAMTSVASTKRDGANDDVANAVVRLPEIVARVATGVQQSIENAKRDGVPDVGLNLVANAPRLISNVFDGVSETVQQAKRDGLEDFLDELLQRLPQLITRSAESALKDSQPVKRDAGSVALSNLIKKSIETVGIENAAQIVSERDISSLIEEYFGKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2025-06-18" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LF9</accession>
    <accession>A0A1D8PQC1</accession>
    <name>MAP2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase 2</fullName>
            <shortName evidence="1">MAP 2</shortName>
            <shortName evidence="1">MetAP 2</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MAP2</name>
        <name type="ordered locus">CAALFM_C604080WA</name>
        <name type="ORF">CaO19.1214</name>
        <name type="ORF">CaO19.8802</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710564.2">
        <property type="nucleotide sequence ID" value="XM_705472.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LF9"/>
    <dbReference type="SMR" id="Q59LF9"/>
    <dbReference type="FunCoup" id="Q59LF9">
        <property type="interactions" value="1224"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LF9"/>
    <dbReference type="EnsemblFungi" id="C6_04080W_A-T">
        <property type="protein sequence ID" value="C6_04080W_A-T-p1"/>
        <property type="gene ID" value="C6_04080W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647837"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604080WA"/>
    <dbReference type="CGD" id="CAL0000186537">
        <property type="gene designation" value="orf19.8802"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04080W_A"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="InParanoid" id="Q59LF9"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="PRO" id="PR:Q59LF9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000407646" description="Methionine aminopeptidase 2">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="446" mass="50379" checksum="16950E829808285B" modified="2017-03-15" version="2">MAGVTEGEDTKVIESKINELNIDKPKLEDNNEAKGNGNGNESGDDDDDDKEEDDDNEITEPSTSTASGDEKKKKNKNKKKKKKKIVSIDSSYPEGIFPEGQWMEYPLEDINSYRTTSEEKRYLDRQQNNKWQDFRKGAEIHRRVRHKAQSSIRPGMTMIEIANLIEDSVRNYSGNDHTLKAGIGFPTGLSLNHVAAHYTPNTGDKLILKKDDIMKVDIGVHVNGRICDSAFTMTFNEDGKYDTIMQAVKEATYTGIKESGIDVRLNDIGAAIQEVMESYEMEENGKTYPIKCIKNLNGHNIDDFVIHSGKSVPIIANGDMTKMEEGETFAIETFGSTGNGYVLPEGECSHYAMNKGVEHLKPPSERSKQLLETIKQNFGTLPWCRRYLERTGEEKYLFALNQLVRHGIVEEYPPIVDKRGSYTAQFEHTILLHPHKKEVVTKGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LK7</accession>
    <name>Q59LK7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">KIC1</name>
        <name evidence="14" type="ordered locus">CAALFM_C204760WA</name>
        <name evidence="13" type="ordered locus">orf19.7821</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710618.1">
        <property type="nucleotide sequence ID" value="XM_705526.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LK7"/>
    <dbReference type="SMR" id="Q59LK7"/>
    <dbReference type="FunCoup" id="Q59LK7">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LK7"/>
    <dbReference type="GeneID" id="3647784"/>
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</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LQ5</accession>
    <accession>A0A1D8PNV8</accession>
    <name>CWC25_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CWC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CWC25</name>
        <name type="ordered locus">CAALFM_C504080CA</name>
        <name type="ORF">CaO19.1281</name>
        <name type="ORF">CaO19.8868</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705570.2"/>
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    </dbReference>
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    <dbReference type="EnsemblFungi" id="C5_04080C_A-T">
        <property type="protein sequence ID" value="C5_04080C_A-T-p1"/>
        <property type="gene ID" value="C5_04080C_A"/>
    </dbReference>
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    <dbReference type="CGD" id="CAL0000183063">
        <property type="gene designation" value="CWC25"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04080C_A"/>
    <dbReference type="eggNOG" id="KOG3869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="PRO" id="PR:Q59LQ5"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth of a unicellular organism"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
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        <property type="entry name" value="CWC25"/>
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        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000079585" description="Pre-mRNA-splicing factor CWC25">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="221" mass="25793" checksum="EF6D19E38092195F" modified="2017-03-15" version="2">MAGDLNLKKSWNPALVKNQQKVWEEEQQKLDELKRIKERNQEYKQEQEYLELLKLQHGDQFQIKDLNKQQKLKISKLNWMYDDVPFEGNEKVEENSSGFIESNVEFTDGKSKVENLLKGNHVVGKKRDGSGTSDRINKIIGVGMTKSSKVSYSDDPLLKIKQQQQQAQRVARKQHPSDKHSHRSRHSSKSSSDRVHKSHEHERSRKHNSSHTRHKDGSPHR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2025-06-18" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q59N29</accession>
    <accession>A0A1D8PNA5</accession>
    <accession>Q59NP8</accession>
    <name>SPB4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent rRNA helicase SPB4</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPB4</name>
        <name type="synonym">SPB41</name>
        <name type="synonym">SPB42</name>
        <name type="ordered locus">CAALFM_C501600CA</name>
        <name type="ORF">CaO19.11631</name>
        <name type="ORF">CaO19.13677</name>
        <name type="ORF">CaO19.4154</name>
        <name type="ORF">CaO19.6298</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711358.2">
        <property type="nucleotide sequence ID" value="XM_706266.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59N29"/>
    <dbReference type="SMR" id="Q59N29"/>
    <dbReference type="FunCoup" id="Q59N29">
        <property type="interactions" value="1237"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59N29"/>
    <dbReference type="EnsemblFungi" id="C5_01600C_A-T">
        <property type="protein sequence ID" value="C5_01600C_A-T-p1"/>
        <property type="gene ID" value="C5_01600C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647252"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501600CA"/>
    <dbReference type="CGD" id="CAL0000185825">
        <property type="gene designation" value="SPB4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01600C_A"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="InParanoid" id="Q59N29"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="PRO" id="PR:Q59N29"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232323" description="ATP-dependent rRNA helicase SPB4">
        <location>
            <begin position="1"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="41"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="265"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="525"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box" evidence="6">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="631" mass="72353" checksum="315908BEEA617889" modified="2005-04-26" version="1">MKSNTESLAWENLRYDLHSWIKEAISSMGYPTMTPVQASTIPLLSGNKDVVVEAVTGSGKTLSFVIPVLQKISDRLYKPDSDGDLPEPVKRGHMLSIVLSPTRELANQIQSVFNQVLQYLPEDKGTRINTQLLVGSIGNVREDLNQFLTNQPQILIGTPGRILEFLGSSQSIKTSSLEIVILDEADKLLDFSFEKDVINILKKLPKQRRTGLFSATISSAGNTIFRTGMNNPVKVQVKSKNYFGEQSNSPKSLQLSYMMINPELKITTLLTILSKYQYKKAIVYFPTCTSVKHFYQIFNKVYQQESSDEPLKFFSLHGQLNTKSRLKTLDNFTQGDINLYKHILMTTDVAARGIDIPDVDLVIQIDPPTDPNVFLHRCGRTGRANKVGRAIVMLNDNCQEEDYIGFMEVKGIFLTKQDIPTSSATKNLHENFQIKLRQYMLEDRARHELAVKSYVGFIRYYSKHIASSIFRLATLDYLGIAKMYGLLRLPKMPETKYIDNSIMPTDGWLGEIIDMDKYSYADKLQEKTRLENLENDKLKKIQDAKRRKELKIKNEAWSSKSERKENKLDRKEKLKRKREAIEKQIMEEERLNDGGNKDEEDEVVEDWKDMVRKNKKKQKKNNSIQGSFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PS7</accession>
    <name>Q59PS7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_CR05750WA</name>
        <name evidence="3" type="ordered locus">orf19.13958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711703.1">
        <property type="nucleotide sequence ID" value="XM_706611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PS7"/>
    <dbReference type="SMR" id="Q59PS7"/>
    <dbReference type="STRING" id="237561.Q59PS7"/>
    <dbReference type="GeneID" id="3646696"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05750WA"/>
    <dbReference type="CGD" id="CAL0000200020">
        <property type="gene designation" value="orf19.13958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05750W_A"/>
    <dbReference type="eggNOG" id="ENOG502SEW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046648_3_0_1"/>
    <dbReference type="InParanoid" id="Q59PS7"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18610">
        <property type="entry name" value="GH130_BT3780-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106:SF5">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000200020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW31291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="342" mass="38517" checksum="CCF4B91775B60505" modified="2005-04-26" version="1">MRIPLINRNSIEGCKDYKPPSSFPIGPFKKWHHNPIMKPDPNVEWESSYLYNATAIVIDDKVFMLYRAQNKDKLSSVGIAWSEDGINFVKHKKPVITATESYEQGGGCEDPRIVRDPVSKLFVVTYTSYDRITARLCVATSEDLFHWTKHGPIVPPYWQDIAVASNGTNMIRNNWSKSGSIFTEKAPDGKYYMIWGDSELHLAESVDLVNWNLTNNSANWNTWAKAIFTRENKLLESGPAPVKMAGNANQWIFVYNAATTGGGDLPKNAYTVNQMLIDYNDIRKGPVARLEQPVLKPESANEREGQVNQVVFCEGLVQFKGQWFLYFGQGDSELGVAIAPVN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q59R24</accession>
    <accession>A0A1D8PRE3</accession>
    <accession>Q3MNZ4</accession>
    <name>TIM9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM9</name>
        <name type="ordered locus">CAALFM_C703630CA</name>
        <name type="ORF">CaJ7.0415</name>
        <name type="ORF">CaO19.13988</name>
        <name type="ORF">CaO19.6696</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331040.1">
        <property type="nucleotide sequence ID" value="XM_019475495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59R24"/>
    <dbReference type="SMR" id="Q59R24"/>
    <dbReference type="FunCoup" id="Q59R24">
        <property type="interactions" value="948"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59R24"/>
    <dbReference type="EnsemblFungi" id="C7_03630C_A-T">
        <property type="protein sequence ID" value="C7_03630C_A-T-p1"/>
        <property type="gene ID" value="C7_03630C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646243"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703630CA"/>
    <dbReference type="CGD" id="CAL0000177007">
        <property type="gene designation" value="TIM9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03630C_A"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="InParanoid" id="Q59R24"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000008">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000228041" description="Mitochondrial import inner membrane translocase subunit TIM9">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Twin CX3C motif">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAE44866." evidence="2" ref="1">
        <original>NALLMQQGPK</original>
        <variation>KYVDLSRVTNGNMPLMIIIIYHQIILTNKLILL</variation>
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="87" mass="10202" checksum="5E78FE30BDA92055" modified="2017-03-15" version="2">MDQLNVKEQQEFQQIVEQKQMKDFMNLYSNLVSRCFDDCVNDFTSNSLTSKETSCIAKCSEKFLKHSERVGQRFQEQNALLMQQGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RQ6</accession>
    <name>Q59RQ6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LPD1</name>
        <name evidence="15" type="ordered locus">CAALFM_CR07400CA</name>
        <name evidence="14" type="ordered locus">orf19.13546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
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            <name>FAD</name>
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        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
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    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
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    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
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    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <position position="73"/>
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            <name>NAD(+)</name>
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    <sequence length="491" mass="52857" checksum="80C935977DE0E0A9" modified="2005-04-26" version="1">MLRSFKSIPANGKLAQFVRYASTKKYDVVVIGGGPGGYVAAIKAAQLGLNTACIEKRGALGGTCLNVGCIPSKSLLNNSHLLHQIQHEAKERGISIQGEVGVDFPKLMAAKEKAVKQLTGGIEMLFKKNKVDYLKGAGSFVNEKTVKVTPIDGSEAQEVEADHIIVATGSEPTPFPGIEIDEERIVTSTGILSLKEVPERLAIIGGGIIGLEMASVYARLGSKVTVIEFQNAIGAGMDAEVAKQSQKLLAKQGLDFKLGTKVVKGERDGEVVKIEVEDVKSGKKSDLEADVLLVAIGRRPFTEGLNFEAIGLEKDNKGRLIIDDQFKTKHDHIRVIGDVTFGPMLAHKAEEEGIAAAEYIKKGHGHVNYANIPSVMYTHPEVAWVGLNEEQLKEQGIKYKVGKFPFIANSRAKTNMDTDGFVKFIADAETQRVLGVHIIGPNAGEMIAEAGLALEYGASTEDISRTCHAHPTLSEAFKEAALATFDKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T43</accession>
    <name>Q59T43_CANAL</name>
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        <recommendedName>
            <fullName evidence="12">Myb-like DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C205640WA</name>
        <name evidence="9" type="ordered locus">orf19.14163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707711.1"/>
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    <dbReference type="AlphaFoldDB" id="Q59T43"/>
    <dbReference type="SMR" id="Q59T43"/>
    <dbReference type="STRING" id="237561.Q59T43"/>
    <dbReference type="GeneID" id="3645566"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205640WA"/>
    <dbReference type="CGD" id="CAL0000179117">
        <property type="gene designation" value="orf19.14163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05640W_A"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426985_0_0_1"/>
    <dbReference type="InParanoid" id="Q59T43"/>
    <dbReference type="OMA" id="ASNWVKI"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000315"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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        <source>
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    <sequence length="607" mass="67558" checksum="6D0BA03734C78A34" modified="2005-04-26" version="1">MFNRPEHYPPQHINQPHQDPNLNHQPFNYSHQYNGLPPIGMMMQSNTHYQPQAQPQVPQPTAIPHSQLPVHLQQQQQQQPPLVQQHHYIHQQPVFHQSNHMVTHDHKPSTSSSHKRGPWSREEDEKLLELIKIHGASNWVKISSSLETRTAKQCRERYHQNLKPSLNRSPITPEEGAKIERLVAIHGKKWAEISRHLEGRSDNAIKNWWNGGANRRRRASLATTTSSINGNNSIAEELQRKSPTPETATINSEAEMTNKQDSTYSKSILPQPQPQPQPSQSITNYPPASAPVQPQPFQHAQPQRLPSFHQLPQIAFKTSMFGKDNEKSTLPSLSKSLHPSSLSSSTPPPPENHQAAAGSSPLKSISHRSASFDINSNILPPISQSNKRRLIDDQFGRRHSSVSSTIFHNQKNVSHPNLLLVHSARTSVSGPSGSNYGTGSPSYNGSPLSMSTAASRNNSITHFELINNSTIPSRRSSTFNSDLFPNPLAKENNNGNDNHKRRESQNSSFNSPMLTPSTRFSVSSMTSVHNSTIHNYNSSSVTSPTTSFKNAYSASSTSINLPVEEEEPETGADKQKINEPSKDEVTAEQNGDEKVGKKRMAVSSLLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59W50</accession>
    <accession>A0A1D8PF37</accession>
    <name>CWC2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CWC2</name>
        <name type="ordered locus">CAALFM_C111280WA</name>
        <name type="ORF">CaO19.674</name>
        <name type="ORF">CaO19.8291</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713807.1">
        <property type="nucleotide sequence ID" value="XM_708714.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q59W50"/>
    <dbReference type="EnsemblFungi" id="C1_11280W_A-T">
        <property type="protein sequence ID" value="C1_11280W_A-T-p1"/>
        <property type="gene ID" value="C1_11280W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644554"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111280WA"/>
    <dbReference type="CGD" id="CAL0000184865">
        <property type="gene designation" value="orf19.8291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11280W_A"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_0_1_1"/>
    <dbReference type="InParanoid" id="Q59W50"/>
    <dbReference type="OMA" id="WYNKWSQ"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="PRO" id="PR:Q59W50"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000081541" description="Pre-mRNA-splicing factor CWC2">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="363" mass="41272" checksum="4AFFBB5543523293" modified="2005-04-26" version="1">MSRKVSISSLTLSEPMTKPARVQVNPEDIDDLDKTQQVNNHQYNIWYSKSLSDANNKSTTKSKYRVRISTDQGFTKANKNTHICLFFSRGCCYLGSKCQYFHRLPKESDNFKPTQDCFGRDKTANYRDDMDGVGSLNKVNCTLYVGGIHIKPNTEQLLVKNFQEFGTVEKVRVLQGKGCAFVTMKTENQAQFAKEAMQSQSLVEGSNEVLYVRWANEDKNPAAQKQEKKRQQELAYDTVKQLLEQESNKKPRLENGAVNRIETINIDDESEDEGAVEDDEADDDIEETRVNSLSAGVKKNVSTHQANGTPESSSTSDENDHNTILRNSLLKDISRLKKKMVYKREEPYLTNLLVDYSSDEDDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WU8</accession>
    <accession>A0A1D8PPH8</accession>
    <accession>A0A1D8PPH9</accession>
    <name>KAR5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Nuclear fusion protein KAR5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Karyogamy protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KAR5</name>
        <name type="ordered locus">CAALFM_C601010WA</name>
        <name type="ordered locus">CAALFM_C601020WA</name>
        <name type="ORF">CaO19.7750</name>
        <name type="ORF">orf19.103</name>
        <name type="ORF">orf19.104</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW30047" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AOW30047" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5 6">
        <conflict type="miscellaneous discrepancy">
            <sequence resource="EMBL-CDS" id="AOW30047" version="1"/>
        </conflict>
        <text>Contains ambiguous sequence between ORF C6_01010W_A and C6_01020W_A. Used assembly 19 sequence to merge the 2 ORFs.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AOW30048" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5 6">
        <conflict type="miscellaneous discrepancy">
            <sequence resource="EMBL-CDS" id="AOW30048" version="1"/>
        </conflict>
        <text>Contains ambiguous sequence between ORF C6_01010W_A and C6_01020W_A. Used assembly 19 sequence to merge the 2 ORFs.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30047.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30048.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714312.2">
        <property type="nucleotide sequence ID" value="XM_709219.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714313.1">
        <property type="nucleotide sequence ID" value="XM_709220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WU8"/>
    <dbReference type="SMR" id="Q59WU8"/>
    <dbReference type="FunCoup" id="Q59WU8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WU8"/>
    <dbReference type="GlyCosmos" id="Q59WU8">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="3644049"/>
    <dbReference type="GeneID" id="3644050"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601010WA"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601020WA"/>
    <dbReference type="HOGENOM" id="CLU_039530_0_0_1"/>
    <dbReference type="InParanoid" id="Q59WU8"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0415">Karyogamy</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000308770" description="Nuclear fusion protein KAR5">
        <location>
            <begin position="16"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="445"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="15123810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="24025428"/>
        </source>
    </evidence>
    <sequence length="485" mass="56008" checksum="8C06EE251E03D0C3" modified="2017-03-15" version="2" precursor="true">MNIVLLIYCLAMVVAHDLQLFGDFKFELSDNWRNDCAKKALEPIINQCAEGIETISPFQQKSIAIQLSICEFENAEISYPSECRSQNLDTCILLLEKSPQYWTTFSGYYREIRNICHQVSLPFAKDQILQVYGNITEFYRTLMDEMTNSSKYTENMQNELKAKFDKLIGVIDLILADREKNREDLKSSFNMFKNNFEKSLNNALVVMKHSYEDANSNVKELESHLNYFINDMSQVYILINEKALEVKSQQDRIKEHNADILNQIEEIKKNLDNAYEEASEVQISNNQLVHDIQSSLDYSLFTVSNLNSHLQLSINDFIEKNEDIRSRAPIIFEEIFGLFLNHLNESGQLAMDSFEAALDLSLNMLHQKLNQTERSIDNLNSKVSDLAHFADSLKKYASSIFNVPNYVRTSMNHKIQQWREFGNIMVVGGVFFFVVLTLLVLSFIRTQVMKVFRFAFIGIPMITGIALAIFILRLLSMPMKVVDID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XY9</accession>
    <accession>A0A1D8PIN0</accession>
    <accession>Q59XU3</accession>
    <name>OCA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">OCA1</name>
        <name type="ordered locus">CAALFM_C210190CA</name>
        <name type="ORF">CaO19.1762</name>
        <name type="ORF">CaO19.9331</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative tyrosine-protein phosphatase required for protection against superoxide stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714407.2">
        <property type="nucleotide sequence ID" value="XM_709314.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XY9"/>
    <dbReference type="SMR" id="Q59XY9"/>
    <dbReference type="BioGRID" id="1227023">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59XY9">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59XY9"/>
    <dbReference type="EnsemblFungi" id="C2_10190C_A-T">
        <property type="protein sequence ID" value="C2_10190C_A-T-p1"/>
        <property type="gene ID" value="C2_10190C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643929"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210190CA"/>
    <dbReference type="CGD" id="CAL0000196452">
        <property type="gene designation" value="OCA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10190C_A"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047845_2_2_1"/>
    <dbReference type="InParanoid" id="Q59XY9"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="PRO" id="PR:Q59XY9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000304"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
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    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000333389" description="Putative tyrosine-protein phosphatase OCA1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="269" mass="30723" checksum="35F69F99C9B080FE" modified="2017-03-15" version="2">MASITSNSQILINNDSSTNKAPTTNERQLRRINHPPNLRIVPPLNFCPVENQLYRSGQPSIINQSFLNQLNLKTIIWLSSEEPTDEFLEYCNDSSINIEYLGMINEFNSEPATATTTDKQSQSQSQSQSEEQKSQSQSQSQENQHHQFEQSDNNLLQDPSHLISSTIAKINNNNPWDSLNENTIKHALDLIVDKTNYPILICCGMGRHRTGTVIGCLRRLQHWNLNSVSEEYRRFTGSRGGRILVELLIESFNIDLVNINWELAPDWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Y38</accession>
    <name>Q59Y38_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C208650WA</name>
        <name evidence="2" type="ordered locus">orf19.11094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714455.1">
        <property type="nucleotide sequence ID" value="XM_709362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Y38"/>
    <dbReference type="SMR" id="Q59Y38"/>
    <dbReference type="STRING" id="237561.Q59Y38"/>
    <dbReference type="GeneID" id="3643908"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208650WA"/>
    <dbReference type="CGD" id="CAL0000178426">
        <property type="gene designation" value="orf19.11094"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08650W_A"/>
    <dbReference type="eggNOG" id="KOG3456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083053_1_0_1"/>
    <dbReference type="InParanoid" id="Q59Y38"/>
    <dbReference type="OMA" id="TPFANEH"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000004">
        <property type="entry name" value="Lactobacillus shifted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000178426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="157" mass="17828" checksum="3C30EAA54B974207" modified="2005-04-26" version="1">MLRITRLSTRQLVFLRFNSSVTSRPDVARPEASQLTKKDLQSNAFANQAPNRNVTWSPSQEERIEIISKYPYRFVQKDLEEQPRPYAAIDLIAKEPIKYLSHEQGNIAVCDGNRGSTLQGHPKVFINLDQPKAATCGYCGLRYAKEEFKELIEAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YD2</accession>
    <name>Q59YD2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C209600CA</name>
        <name evidence="4" type="ordered locus">orf19.8972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714566.1">
        <property type="nucleotide sequence ID" value="XM_709473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YD2"/>
    <dbReference type="SMR" id="Q59YD2"/>
    <dbReference type="FunCoup" id="Q59YD2">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YD2"/>
    <dbReference type="GeneID" id="3643799"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209600CA"/>
    <dbReference type="CGD" id="CAL0000181446">
        <property type="gene designation" value="orf19.8972"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09600C_A"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="InParanoid" id="Q59YD2"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000181446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18750" checksum="B9311B3076585698" modified="2005-04-26" version="1">MVKFLLKASAELSNVTGLEPSDTPEHPYEYTFQIECTKCRTTHDKDIQINQYEKHEISGSRGEASFVFRCKECKHEHSASILRTNEKLSTTEDSVNDKASATILEIDARGIDFLKFIPIGEFSAVGSETNTKFADIDLSEGEWYDVDEKSNDEVSIVDVSWEISRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q59ZV4</accession>
    <accession>A0A1D8PFW7</accession>
    <name>KFA_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
            <shortName evidence="1">KFA</shortName>
            <shortName evidence="1">KFase</shortName>
            <ecNumber evidence="1">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-formylkynurenine formamidase</fullName>
            <shortName evidence="1">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BNA7</name>
        <name type="ordered locus">CAALFM_C114270WA</name>
        <name type="ORF">CaO19.7237</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW27027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715037.1">
        <property type="nucleotide sequence ID" value="XM_709944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59ZV4"/>
    <dbReference type="SMR" id="Q59ZV4"/>
    <dbReference type="FunCoup" id="Q59ZV4">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59ZV4"/>
    <dbReference type="ESTHER" id="canal-bna7">
        <property type="family name" value="Kynurenine-formamidase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_14270W_A-T">
        <property type="protein sequence ID" value="C1_14270W_A-T-p1"/>
        <property type="gene ID" value="C1_14270W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643309"/>
    <dbReference type="KEGG" id="cal:CAALFM_C114270WA"/>
    <dbReference type="CGD" id="CAL0000192193">
        <property type="gene designation" value="orf19.7237"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_14270W_A"/>
    <dbReference type="eggNOG" id="ENOG502S28Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016852_1_0_1"/>
    <dbReference type="InParanoid" id="Q59ZV4"/>
    <dbReference type="OMA" id="DHYDIMK"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="chain" id="PRO_0000361881" description="Kynurenine formamidase">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <sequence length="267" mass="30609" checksum="4E1B92AE06554649" modified="2005-04-26" version="1">MEDISEEQEFKYGEHSLQKIKVFKYSSTNASTYIYIHGGAWRDPSNTFDEMRPVLGIPNANLIGINYRLSPEIKHPEHLIDILRALRFVKQNFDVSQITLLGHSVGATMILQLLHYRQIIRDGLKHTHKDDLSSLDNLFAYVNDNVLLSQVIFLDGIYDVVELLKEYPDYASFVDDAFVSNKHFADSTQLSSANESLDLPFSLVSKDTKFLIYQSLEDDLLSMKQTHLLIDYLSSKNQGFTLHVGNWGKHEEIFGKYREIVFSGNVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2025-06-18" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1B0</accession>
    <accession>Q96W98</accession>
    <name>ERG26_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
            <ecNumber evidence="5">1.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">C-3 sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ERG26</name>
        <name type="ordered locus">orf19.2909</name>
        <name type="ORF">CAALFM_C406270CA</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="FEMS Yeast Res." volume="1" first="93" last="101">
            <title>The Candida albicans ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) is essential for growth.</title>
            <authorList>
                <person name="Aaron K.E."/>
                <person name="Pierson C.A."/>
                <person name="Lees N.D."/>
                <person name="Bard M."/>
            </authorList>
            <dbReference type="PubMed" id="12702354"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2001.tb00020.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="2226" last="2236">
            <title>Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.</title>
            <authorList>
                <person name="Liu T.T."/>
                <person name="Lee R.E."/>
                <person name="Barker K.S."/>
                <person name="Lee R.E."/>
                <person name="Wei L."/>
                <person name="Homayouni R."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="15917516"/>
            <dbReference type="DOI" id="10.1128/AAC.49.6.2226-2236.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 9">Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:12702354). ERG26 is a catalytic component of the C-4 demethylation complex that catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group (PubMed:12702354). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:33447"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:50593"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:64925"/>
            <dbReference type="EC" id="1.1.1.170"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:33448"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6 7">Expression is repressed by amphotericin B and caspofungin (PubMed:15917516). Expression is also repressed during biofilm formation (PubMed:22265407).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Impairs growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.170" evidence="5"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715564.1">
        <property type="nucleotide sequence ID" value="XM_710471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1B0"/>
    <dbReference type="SMR" id="Q5A1B0"/>
    <dbReference type="FunCoup" id="Q5A1B0">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1B0"/>
    <dbReference type="EnsemblFungi" id="C4_06270C_A-T">
        <property type="protein sequence ID" value="C4_06270C_A-T-p1"/>
        <property type="gene ID" value="C4_06270C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642803"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406270CA"/>
    <dbReference type="CGD" id="CAL0000199131">
        <property type="gene designation" value="ERG26"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06270C_A"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="InParanoid" id="Q5A1B0"/>
    <dbReference type="OMA" id="STAHWFD"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="BRENDA" id="1.1.1.170">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00770">
        <property type="reaction ID" value="UER00757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102175">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd09813">
        <property type="entry name" value="3b-HSD-NSDHL-like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <feature type="chain" id="PRO_0000454175" description="Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A059TC02"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P53199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q12068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12702354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15917516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="12702354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="350" mass="39184" checksum="A18DABB1A1EA4636" modified="2005-04-26" version="1">MSESLQSVLIIGGSGFLGLHLIEQFYRHCPNVAITVFDVRPLPEKLSKYFTFDPSKIQFFKGDLTSDKDVSDAINQSKCDVIVHSASPMHGLPQEIYEKVNVQGTKNLLSVAQKLHVKALVYTSSAGVIFNGQDVINADETWPYPEVHMDGYNETKAAAEEAVMKANDNDQLRTVCLRPAGIFGPGDRQLVPGLRASAKLGQSKYQLGDNNNLFDWTYVGNVADAHVLAAQKILDKSTRDDISGQTFFITNDSPTYFWTLARTVWKNDGYIDKYYIKLPYPVALTLGYISEFVAKNILKKEPGITPFRVKVVCAIRYHNIAKAKKLLGYKPEVDLETGINYTLDWMNEDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-04-09" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1M4</accession>
    <accession>A0A1D8PN31</accession>
    <name>TRY3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator of yeast form adherence 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TRY3</name>
        <name type="ordered locus">CAALFM_C500980WA</name>
        <name type="ORF">CaO19.1971</name>
        <name type="ORF">CaO19.9527</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor required for yeast cell adherence to silicone substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is induced in biofilm.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Decreases cell adherence to silicone substrate.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715733.2">
        <property type="nucleotide sequence ID" value="XM_710640.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1M4"/>
    <dbReference type="SMR" id="Q5A1M4"/>
    <dbReference type="STRING" id="237561.Q5A1M4"/>
    <dbReference type="EnsemblFungi" id="C5_00980W_A-T">
        <property type="protein sequence ID" value="C5_00980W_A-T-p1"/>
        <property type="gene ID" value="C5_00980W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642652"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500980WA"/>
    <dbReference type="CGD" id="CAL0000186243">
        <property type="gene designation" value="TRY3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00980W_A"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017137_2_1_1"/>
    <dbReference type="InParanoid" id="Q5A1M4"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="PRO" id="PR:Q5A1M4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd23137">
        <property type="entry name" value="RING-HC_TRY3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000980">
        <property type="entry name" value="Transcriptional regulator of yeast form adherence 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000426090" description="Transcriptional regulator of yeast form adherence 3">
        <location>
            <begin position="1"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="1">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="494" mass="57301" checksum="4D4562193BBB6CDD" modified="2017-03-15" version="2">MKFAKTLERTLEEDEIPQEWVEAAIQYKALKKCINKVVNELEFLGLQKNTLKILLNDKVVEVNEQETNPSNPIIAEYILSKTSTDAHNIKPMLKITLDYSSEDYTKDHIVELGKELKQKIEALLNDSDTEYEEDKIIELKEDDGGDLQIVTSREGSLSPPASRMASPPTSPTLKVVDSLNTNIDEALLSPDDHHKKHEIFIMLNSDSKFFEMLNDELNSLDTLTQQEESKIIEEVKKIAKYVNELKLKQSELYKWRELFKVYLDSEVYFKYNETALPSQQKSSEQIKSNLDLFVTNLNKSGIMTRFKKKQSLETFNQFMEMNYHLLKILQFQTINNEALRKILKKFDKQTSLGIQKTFPKLISNDHIFMSGSSLAQSICYIIQESIIKVIPQLDDYSCPICMNIAYKPIRLSCGHLFCVRCLVKMKQDDKTSCPLCRKENAILYADSSNLDLESMELMKKYFPREVKEKLRERDKERYNELRKNANSGEKCIVM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2025-04-09" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A2B9</accession>
    <accession>A0A1D8PDK3</accession>
    <accession>Q5A2H1</accession>
    <name>SPT20_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor SPT20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPT20</name>
        <name type="ordered locus">CAALFM_C105430WA</name>
        <name type="ORF">CaO19.422</name>
        <name type="ORF">CaO19.8052</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="FEMS Microbiol. Lett." volume="245" first="25" last="32">
            <title>DNA array analysis of Candida albicans gene expression in response to adherence to polystyrene.</title>
            <authorList>
                <person name="Marchais V."/>
                <person name="Kempf M."/>
                <person name="Licznar P."/>
                <person name="Lefrancois C."/>
                <person name="Bouchara J.P."/>
                <person name="Robert R."/>
                <person name="Cottin J."/>
            </authorList>
            <dbReference type="PubMed" id="15796975"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2005.02.014"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="2226" last="2236">
            <title>Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.</title>
            <authorList>
                <person name="Liu T.T."/>
                <person name="Lee R.E."/>
                <person name="Barker K.S."/>
                <person name="Lee R.E."/>
                <person name="Wei L."/>
                <person name="Homayouni R."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="15917516"/>
            <dbReference type="DOI" id="10.1128/AAC.49.6.2226-2236.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Mol. Biol. Cell" volume="20" first="2389" last="2400">
            <title>Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans.</title>
            <authorList>
                <person name="Sellam A."/>
                <person name="Askew C."/>
                <person name="Epp E."/>
                <person name="Lavoie H."/>
                <person name="Whiteway M."/>
                <person name="Nantel A."/>
            </authorList>
            <dbReference type="PubMed" id="19279142"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-11-1093"/>
        </citation>
        <scope>IDENTIFICATION IN THE SAGA COMPLEX</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E94468" last="E94468">
            <title>The role of Candida albicans SPT20 in filamentation, biofilm formation and pathogenesis.</title>
            <authorList>
                <person name="Tan X."/>
                <person name="Fuchs B.B."/>
                <person name="Wang Y."/>
                <person name="Chen W."/>
                <person name="Yuen G.J."/>
                <person name="Chen R.B."/>
                <person name="Jayamani E."/>
                <person name="Anastassopoulou C."/>
                <person name="Pukkila-Worley R."/>
                <person name="Coleman J.J."/>
                <person name="Mylonakis E."/>
            </authorList>
            <dbReference type="PubMed" id="24732310"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0094468"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5 6">Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs) (By similarity). SPT20 plays a role in nuclear division and regulates hyphal and biofilm formation, which are crucial steps for virulence.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the SAGA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4">Expression is down-regulated by flucytosine and upon adherence to polystyrene.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Impairs proper nucleus dividing and distribution to the dividing cells. Leads to hypersensitivity to amphotericin B, fluconazole and caspofunginreduced; and to reduced virulence in the C.elegans and the G.mellonella infection models.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SPT20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715857.2">
        <property type="nucleotide sequence ID" value="XM_710764.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A2B9"/>
    <dbReference type="STRING" id="237561.Q5A2B9"/>
    <dbReference type="EnsemblFungi" id="C1_05430W_A-T">
        <property type="protein sequence ID" value="C1_05430W_A-T-p1"/>
        <property type="gene ID" value="C1_05430W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642492"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105430WA"/>
    <dbReference type="CGD" id="CAL0000196043">
        <property type="gene designation" value="SPT20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05430W_A"/>
    <dbReference type="eggNOG" id="ENOG502QS30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377649_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A2B9"/>
    <dbReference type="OMA" id="HNYNEHI"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="PHI-base" id="PHI:4208"/>
    <dbReference type="PRO" id="PR:Q5A2B9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000431519" description="Transcription factor SPT20">
        <location>
            <begin position="1"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P50875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15796975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15917516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="24732310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="19279142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="751" mass="83963" checksum="91C753AF2CC0A718" modified="2017-03-15" version="2">MIKSEVLSGSASKTVGNSISNGTTVSTQNQGGKQNLIRQQQQQQQQQQQQQQQQQQQQLKHRTALQNYHFASTSEEILKKYSKYPASMSLHIFETHYRFNNSQDSQVIPKDSPMIKDFMKHVLKEQIPVEMCELIKDFAIRPYDGCIILQVYDHRNMVKTAVLQNRSTSSPSKDQDKKQQMVVSKPRTYRTLLRPTSLSIYYDLLYHTDSALHRFTDYLSLQMESEILTATNRELNLSVPLNPYNYDHLRPEPEPSGDMSQNSDEEIDQVKFQHRDAVEQPRRKIHQDEMVLHKSSEYEELMLLLSNKHKRPDDCSDKRLVVVSTSALPGSSLTGTSNTSTGTAAATPTPTSTTASAASQSSKQTTADGASTTDTKGKKGDKANGTSANQASASPTSVHPPIPTIPQNSVRATGQFMRLRLIEEIRKKRELEKLQQEAKIQAQANAIQSDSVPPSQQLAPQNTINSPVVTEPTKRSSPAAQNQPAPKRAKKETKKQLQAKAQAQAKAQAQAKAKVQTETPGPTPVQGQNSLSGPSVVNGSNVTSTANTPTMNNQSSLQQPSQASQPQIGSLNNNQQSQSQQQQQKNPQQTLQQQQQQQIFQNSLTPEEQKVYKQIQQNMATLAMMGQSGVTPTGQQLTPQQKQQAIQQAKNLQQQLFQRFPLYFQRMKQLQLIHQKRRLQQQQQQQQQQQQQQASNSSGGNQNNSSNQAAPQTQQFNQALPSTSEQSKPVTTSPEVKKKRTYQKKKNAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A328</accession>
    <name>Q5A328_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR08610WA</name>
        <name evidence="10" type="ordered locus">orf19.13793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716273.1">
        <property type="nucleotide sequence ID" value="XM_711180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A328"/>
    <dbReference type="FunCoup" id="Q5A328">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A328"/>
    <dbReference type="GeneID" id="3642109"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08610WA"/>
    <dbReference type="CGD" id="CAL0000193650">
        <property type="gene designation" value="orf19.13793"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08610W_A"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A328"/>
    <dbReference type="OMA" id="PQQFAIC"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000193650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="132" mass="14694" checksum="2317976E7C3841F2" modified="2005-04-26" version="1">MASTVQHASKFQRFLNSETGPRTVHFWAPVFKWALVAAGLNDIQRPVEKLSGTQQIALFATGAIWTRWAGFVIKPRNMLLASVNFFLGGVAGYQLLRIVNYRRDLGDSPMQVFNYILNGDAAAVKEPEPAKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4N0</accession>
    <accession>A0A1D8PPQ8</accession>
    <accession>O94004</accession>
    <name>ATG15_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Putative lipase ATG15</fullName>
            <ecNumber>3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG15</name>
        <name type="ordered locus">CAALFM_C601740CA</name>
        <name type="ORF">Ca20C1.17</name>
        <name type="ORF">CaO19.10915</name>
        <name type="ORF">CaO19.3412</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3"/>
    <dbReference type="EMBL" id="AL033391">
        <property type="protein sequence ID" value="CAA21938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716721.1">
        <property type="nucleotide sequence ID" value="XM_711628.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4N0"/>
    <dbReference type="FunCoup" id="Q5A4N0">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4N0"/>
    <dbReference type="ESTHER" id="canal-ATG15">
        <property type="family name" value="ATG15-related-lipase"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5A4N0">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_01740C_A-T">
        <property type="protein sequence ID" value="C6_01740C_A-T-p1"/>
        <property type="gene ID" value="C6_01740C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641641"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601740CA"/>
    <dbReference type="CGD" id="CAL0000191921">
        <property type="gene designation" value="ATG15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01740C_A"/>
    <dbReference type="HOGENOM" id="CLU_028295_0_2_1"/>
    <dbReference type="InParanoid" id="Q5A4N0"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="PRO" id="PR:Q5A4N0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000339">
        <property type="entry name" value="Lipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00120">
        <property type="entry name" value="LIPASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000090365" description="Putative lipase ATG15">
        <location>
            <begin position="1"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21938." evidence="6" ref="1">
        <original>E</original>
        <variation>K</variation>
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21938." evidence="6" ref="1">
        <original>D</original>
        <variation>Y</variation>
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P25641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="597" mass="67469" checksum="3B8130FA04964AB4" modified="2005-04-26" version="1">MTLEKNRHANKGTSWTWMIYKFVVGVITVAILVLFITQKSVSQAQDKLRVEQQAIFSDQDTLQLKHIFHHGTGPKNYRLHRRLDITSEYLAKHQPYFTTLTQQLSEPVLEEHIASDNLDKIYQQSDWPEIHKGKNPFSIELPFKKADSEATRLKERNTLNFIESYLNYARDIKGDAQILNRINLDWIHDEIKVPNVTDRDTVVTLATISSNAYVRYPKDDDEKRKSDWIDLGDWDPNREDDDVNFGWDDIGLRGHVFVSKDNKTVVIGIKGTSGAGLPGGGSDETGGNDKTNDNLLFSCCCARISYMWTTVCDCYEKTYTCNQDCLEKELRKEDKYYQAVLELYRNVTDIYPPESTDIWVTGHSLGGALASLLGRTFGLPAVAFEAPGEMLATRRLHLPSPPGLPQHMENIWHFGNTADPIYMGVCNGASSTCNLAGYAMETTCHTGLQCVYDVVTDKGWSVNLLNHRIHTVIDDIILTYNETAPCAPSPPCRDCFNWRFVAHDDNEKDEPKLPNPLRSSSKSTLSTKTTSLKSSSTYSGSTSSSTVTKTTQTSPISSASPTDQDPPKKCLKRTWYGWCTKWGYDDDDDDEDTFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4X6</accession>
    <name>Q5A4X6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C500250CA</name>
        <name evidence="3" type="ordered locus">orf19.8585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716808.1">
        <property type="nucleotide sequence ID" value="XM_711715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4X6"/>
    <dbReference type="SMR" id="Q5A4X6"/>
    <dbReference type="FunCoup" id="Q5A4X6">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="GeneID" id="3641562"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500250CA"/>
    <dbReference type="CGD" id="CAL0000178313">
        <property type="gene designation" value="orf19.8585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00250C_A"/>
    <dbReference type="eggNOG" id="KOG3131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084828_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A4X6"/>
    <dbReference type="OMA" id="THIRCLA"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="207" mass="23884" checksum="B96FB542A7F740A2" modified="2005-04-26" version="1">MDYGQIIRTSKLFQDISLSLENIEISTIRCLALGSPSESKNARFQLALLIELQQLLDAEVSLYDPIFNEKDNEILKDFTIEKEFTSDSSKTLYFLPHASLELTEEVLNTNQPKYFLANDVIAHTDRLTKKKLADNYPTLSIIVHLLGENKVDDGFTRVSRKRFKEPVITYDIDSVYFDKVQISRYLHTNKNDAWGTSFTDLAYHYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A669</accession>
    <name>Q5A669_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rrn9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C404600CA</name>
        <name evidence="2" type="ordered locus">orf19.11302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717226.1">
        <property type="nucleotide sequence ID" value="XM_712133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A669"/>
    <dbReference type="GeneID" id="3641156"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404600CA"/>
    <dbReference type="CGD" id="CAL0000178476">
        <property type="gene designation" value="orf19.11302"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04600C_A"/>
    <dbReference type="eggNOG" id="ENOG502T2HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619625_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A669"/>
    <dbReference type="OMA" id="CEDDIRT"/>
    <dbReference type="OrthoDB" id="4068335at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000178476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45898" checksum="6D9B13C7A4704947" modified="2005-04-26" version="1">MSTKTDRQQVLGVLEDNYTSDLSIHLYSTFLLRRINPNFPRHSWSYWPLRFADVPIPQDDFEDDIVNGYEKDIDDDVSALKRRVSNRKSRAEEATSLEDSTKEDEDTTIYNADVESESEQDEDDNNNEFENEDENLKRLLSRPITEITYLERTPNSKKLLVNSLSSIIQHKIHARIKESNISKNNLAITDDMASNPALVPLTTQLANRFNFLIDNLTRSKTSKKTINWKDILCTAVRGEIGPHSNINAKSYEELYNKCEKLFSTMRYNYEFESELECEDDIRTEDGGFNVHEYLKTLSNSVQASGQISYKDLVSRYPNDFSQREKEEARFKHNFFKLLGIQDQSLDISCSKTKREPEKKRRKVLVVEPKVEDLNEVKEEILGSVELDENSYMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A876</accession>
    <name>Q5A876_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dal81p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DAL81</name>
        <name evidence="9" type="ordered locus">CAALFM_CR01030WA</name>
        <name evidence="8" type="ordered locus">orf19.10762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717943.1">
        <property type="nucleotide sequence ID" value="XM_712850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A876"/>
    <dbReference type="SMR" id="Q5A876"/>
    <dbReference type="FunCoup" id="Q5A876">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A876"/>
    <dbReference type="GeneID" id="3640419"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01030WA"/>
    <dbReference type="CGD" id="CAL0000195779">
        <property type="gene designation" value="DAL81"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01030W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A876"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901717">
        <property type="term" value="P:positive regulation of gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901714">
        <property type="term" value="P:positive regulation of urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="831"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000195779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="878" mass="98618" checksum="B4921D17114CC6ED" modified="2005-04-26" version="1">MDNQSPNFMDQNWTPHMLPQTASYLANLDLPNIPTTHSNNHYNNNNNSGLNPSYNTSSIMQTIQNQHNVHDDQENQQQQHHHHQYINSNSPSSSSHQVTPNPTISSSSSSSKSNKQKRPCDQCRKRKIKCVLVPNTNNCVQCEAKQVTCTYTDQAPKRKLAETTTPANNDQLLKRGRIMDTSLLSNGSTIVPPDVAIREVSPIQDYSAMNNSLLKRTLSLQFPRSSFYVGPTSSVFDINLLNSIIKSHEHQMANGNESTTTARNNNSNNKIEQVSLNNLVSLRKVSDTVQFILKEDQSPQSYQTMSNDVDTIEKFISPHGQILVDLYFRIIHPSYPIIHKKVFIEKYSRTHREFSAPLLAAVYVLAIQWWDYDPQLNRFPKPNVEMILKIGLNNYMLEILKRPKLSAVQAGLLLLQCKHIINCKSSNDGSRQQGGGSSNSNHSNSVATGDADYSEWILCSQIVSLAEELGLGLDCNDWKLPKWERGLRKRLAWAVYLEDKWLSLKLARPSHINESNWMVLPLYDQDFPEKHGDGDLKEGSSDIDNGKKIFIHLIELSKILSDILNQFYSMKAMKEITEIDQVLKLAKPLQLRLRDWFRSLPIELQMSSVQPRKLCSNGFLQLAYFATELTLHRKITTIIFNQTKAGNPPSPELVGVCRSAAKTRLMASIEFVRDLKQEHIHSFWHCSATSNFTLIGTFAAILLMSSSTKEETDFYRDQILNYRWILKISSKGFDQAAEALADLDLVLTNIPGLIYDNINVPSLLPNVSDSLSSIQHFQMSHSPAGASPPQNSTSTITTTTTATATTQQRIRAPIRESPLSSPQNMYTPPLNNNNNNNSNVGNSNKGSPMSNAQGLSPKNKNMSGTTSKSPVKSPELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A885</accession>
    <name>Q5A885_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">SRP54</name>
        <name evidence="17" type="ordered locus">CAALFM_CR01110WA</name>
        <name evidence="16" type="ordered locus">orf19.10753</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717934.1">
        <property type="nucleotide sequence ID" value="XM_712841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A885"/>
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    <dbReference type="FunCoup" id="Q5A885">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A885"/>
    <dbReference type="GeneID" id="3640377"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01110WA"/>
    <dbReference type="CGD" id="CAL0000195229">
        <property type="gene designation" value="SRP54"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01110W_A"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="InParanoid" id="Q5A885"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
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    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
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        <location>
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        </location>
    </feature>
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            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000195229"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30873.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="556" mass="60697" checksum="A0A39451DAC22F64" modified="2005-04-26" version="1">MVLADLGSRLRGALSSVESGSDDEIQQMIKDICSALLESDVNVKLVAKLRGNIKNKIDESNVSKETSAMNKRKKLQKIIFDELCALVDSNVEPPKPKKLSTSTKTINGKKVRLSKESSHVIMFVGLQGAGKTTSCTKLAVYYKKRGFKVGLVCADTFRAGAFDQLKQNAIKANIPYYGSYLEPDPVKIAFEGVQKFKQEKFDIIIVDTSGRHRQEEQLFTEMVQIGEAVQPTQTIMVMDGSIGQAAESQARAFKESSNFGSIILTKMDGHAKGGGAISAVAATKTPIVFIGTGEHVGDLEIFKPTTFISKLLGIGDIQGLIEHVQSLNLHQDEGHKQTIEHIKEGKFTLRDFQNQMNNFLKMGPLTNIASMIPGLSNIMSQVGDEETSKKIKNMIYIMDSMTIKELESDGRIFIKEPSRIVRVARGSGCAVVEVEMILQQHRMMSTMAKSAMAAQGGQPGQPGNPMANNPQMQRMMQQAQSNPNFMQQAMNMLGGAGGGAGGAGGLAGMMNNPAMMQQAQQMMRSNPQMMQQAQQMMKNPGMMQKMMQQFGGMGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A932</accession>
    <name>Q5A932_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GAC1</name>
        <name evidence="4" type="ordered locus">CAALFM_C101140CA</name>
        <name evidence="3" type="ordered locus">orf19.10812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW25809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718125.1">
        <property type="nucleotide sequence ID" value="XM_713032.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5A932"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C101140CA"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01140C_A"/>
    <dbReference type="eggNOG" id="KOG3986">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="242"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="604"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
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            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="588"/>
        </location>
    </feature>
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            <end position="650"/>
        </location>
    </feature>
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            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000184544"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW25809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A9X0</accession>
    <name>Q5A9X0_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">orf19.10050</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718532.1">
        <property type="nucleotide sequence ID" value="XM_713439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A9X0"/>
    <dbReference type="STRING" id="237561.Q5A9X0"/>
    <dbReference type="GeneID" id="3639836"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301120WA"/>
    <dbReference type="CGD" id="CAL0000187024">
        <property type="gene designation" value="orf19.10050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01120W_A"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A9X0"/>
    <dbReference type="OMA" id="ITRPMDN"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000187024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39953" checksum="E6C06F08D1CE4627" modified="2005-04-26" version="1">MNKYISITRSLATAAKKSTTTTTTTTTTTTTTPINNSQPQFKVFDKSTKFLQRSKHAKLTPELSRKKDYLRDEIAIKTIERLAFITRPMDNLLDFGSNAGNFLNQLIKDSKIPSPPLDGKNDDMEVKLIEQLNKDKQIVRDKIKNLIMFDTSKDLLYRDVNETDQNGNFPGKITRCVGNDEETFNHEIFKTDNQYDAVISNLSLHWINDLPKVLTNIHRILKKDGFFMATLFGGDTLYELRTSLQLAELERKGGISPRVSPLIHLNDIGSLLTKAGFSMLTIDSEDIIVNGYPNIINVCEDLQIMGENNGLISRNYLDRDVLIAADQIYKSLHGDEHGLPATFSVIFFIGWKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A9Z6</accession>
    <accession>A0A1D8PDK9</accession>
    <accession>Q9UVI5</accession>
    <name>FAL1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FAL1</name>
        <name type="ordered locus">CAALFM_C105640CA</name>
        <name type="ORF">CaO19.10024</name>
        <name type="ORF">CaO19.2488</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-11" db="EMBL/GenBank/DDBJ databases">
            <title>A novel method for systematic identification of genes required for growth of Candida albicans.</title>
            <authorList>
                <person name="De Backer M.D."/>
                <person name="Logghe M."/>
                <person name="Viaene J."/>
                <person name="Loonen I."/>
                <person name="Vandoninck S."/>
                <person name="de Hoogt R."/>
                <person name="Nelissen B."/>
                <person name="De Waele S."/>
                <person name="Simons F."/>
                <person name="Contreras R."/>
                <person name="Luyten W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>B2630</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AJ250879">
        <property type="protein sequence ID" value="CAB61567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718509.1">
        <property type="nucleotide sequence ID" value="XM_713416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A9Z6"/>
    <dbReference type="SMR" id="Q5A9Z6"/>
    <dbReference type="FunCoup" id="Q5A9Z6">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A9Z6"/>
    <dbReference type="EnsemblFungi" id="C1_05640C_A-T">
        <property type="protein sequence ID" value="C1_05640C_A-T-p1"/>
        <property type="gene ID" value="C1_05640C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639839"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105640CA"/>
    <dbReference type="CGD" id="CAL0000189056">
        <property type="gene designation" value="FAL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05640C_A"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A9Z6"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PRO" id="PR:Q5A9Z6"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097078">
        <property type="term" value="C:FAL1-SGD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232143" description="ATP-dependent RNA helicase FAL1">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="238"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAB61567." evidence="4" ref="1">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAB61567." evidence="4" ref="1">
        <original>K</original>
        <variation>M</variation>
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAB61567." evidence="4" ref="1">
        <original>F</original>
        <variation>L</variation>
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="399" mass="45555" checksum="BA004123E1196DF1" modified="2005-04-26" version="1">MDDFDRDLDNELEFSHKSTKGIKVHRTFESMNLKPDLLKGIYAYGFETPSAIQSRAIMQIISGRDTIAQAQSGTGKTATFSIGMLEVIDTKSKECQALILSPTRELAIQIQNVVKHLGDYMNIHTHACIGGKNVGEDVKKLQQGQQIVSGTPGRVIDVIKRRNLQTRNIKVLILDEADELFTKGFKEQIYEIYKHLPPSVQVVVVSATLPREVLEMTSKFTTDPVKILVKRDEISLSGIKQYYVQCEREDWKFDTLCDLYDNLTITQAVIFCNTKLKVNWLADQMKKQNFTVVAMHGDMKQDERDSIMNDFRRGNSRVLISTDVWARGIDVQQVSLVINYDLPTDKENYIHRIGRSGRFGRKGTAINLITKDDVVTLKEFEKYYSTKIKEMPMNINDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AA15</accession>
    <name>Q5AA15_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad10p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">RAD10</name>
        <name evidence="10" type="ordered locus">CAALFM_C105820CA</name>
        <name evidence="9" type="ordered locus">orf19.10006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    </feature>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
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            <dbReference type="CGD" id="CAL0000193633"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="338" mass="37218" checksum="4C30F2A6589BEE6E" modified="2005-04-26" version="1">MSNTKDNANDIDASSFASILAGVQKMREDAGSIPSQDPTLAEVNHDTQPNASSLNAIQPPAPVPAPPPQTHTNVTNEKYQKATLNESTAKPIPPKRNNNSVKPSTKRTQTSGPSDILVSRSQEGNPLLSTPIMQATPWSFDKSLLSDYYINPKFQIIFLTLKYHKLHPEHIWNRWKKLNQGSSTVHTRGDDALRVLLVVVDVDSHQDLLRKLSDFCIKHDLSLVLAWSYEEAANYIALCKQLDKAPLKGRKIIEGTKGSDYNSSVVKAFTGIKSVNKTDVSNLLANCKSVKEIVLQSCQNDNDDGIGLASIPGLGAKKLENLKKVFSEPFISNKDYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
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    <name>Q5ADN7_CANAL</name>
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            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C306970WA</name>
        <name evidence="13" type="ordered locus">orf19.14096</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_714806.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ADN7"/>
    <dbReference type="SMR" id="Q5ADN7"/>
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    <dbReference type="STRING" id="237561.Q5ADN7"/>
    <dbReference type="GeneID" id="3638506"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306970WA"/>
    <dbReference type="CGD" id="CAL0000186213">
        <property type="gene designation" value="orf19.14096"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06970W_A"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_018649_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ADN7"/>
    <dbReference type="OMA" id="LAYIKYN"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000009">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000186213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="606" mass="70059" checksum="54D8BC0875906795" modified="2005-04-26" version="1">MESPLATTLGTRMSAYLITSNDFKKQRQKINKQIKNLRHELNLINHDSKKYKVVKFTKDQYQSNKNYGLIYLLLAERDFLYGLEMKNILEIDDIKSKSKSKSNSNSKLHKNYKKLLITKFKRSLIHAKELLDLTNEESINDIKVELFVYTALIIGQLSIVKKNWEKTLHAFSIAKCGLDYLYNTHNNNNNNNNNNGEDENNDDDEEEADSFNKTLFNELIETLVDPSLNLAISQLEIHSTTDLKSIARKHCHDNEVPYLTPVLNLIDSKYTTTAENIANEDNFEISKQVNWRDHSAYIYNDEVALKISYLNNNIHWDKSNDINQFDSIITQWNEILSLHKSDTERNQDDDDLEQVQNRAILLTYINYNLLFTTLKRDLLLIGQLAKIDDNKDIIRLFNGILVIVQNLKDLPGVYNDEDLYDSLDNLEKFFIAQKNQVIAESYQFNSQFAESLKIYQFINQEISNATTTTKQGSSSFYKTDFPFNISTNEQIAIFKNDITKKILQNQISAQFEQSKVISSSPYTIENLNKYPKGLTTIINLNKIEPMMCKPVLFDVAFNYISYDSTKQTTTNTATTTPVETSSPDVDETIDNENSKKRGFFGIFGRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADQ6</accession>
    <name>RS12_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein eS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS12</name>
        <name type="ordered locus">orf19.6785</name>
        <name type="ORF">CAALFM_C307150CA</name>
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    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_719881.1">
        <property type="nucleotide sequence ID" value="XM_714788.1"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
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        <property type="resolution" value="2.56 A"/>
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        <property type="resolution" value="2.64 A"/>
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        <property type="resolution" value="2.77 A"/>
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        <property type="resolution" value="2.67 A"/>
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        <property type="resolution" value="2.90 A"/>
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    <dbReference type="PDBsum" id="7PZY"/>
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    <dbReference type="PDBsum" id="9G1Z"/>
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    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="Q5ADQ6"/>
    <dbReference type="EMDB" id="EMD-13737"/>
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    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="Q5ADQ6"/>
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        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADQ6"/>
    <dbReference type="EnsemblFungi" id="C3_07150C_A-T">
        <property type="protein sequence ID" value="C3_07150C_A-T-p1"/>
        <property type="gene ID" value="C3_07150C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638438"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307150CA"/>
    <dbReference type="CGD" id="CAL0000200890">
        <property type="gene designation" value="RPS12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07150C_A"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ADQ6"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456550" description="Small ribosomal subunit protein eS12">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="143" mass="15698" checksum="D45AB11AE511904E" modified="2005-04-26" version="1">MSDVEQEQIVEEVVVEEQSGAITIEDALKVVLRTSLVHDGLARGLREASKALSKREAQLCVLCDSVTEESIIKLVEALCNEPEEKIPLIKVSDAKLLGEWAGLCQLDRDGNARKVVGASCVVVKNWGADSDERNILLEHFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADW1</accession>
    <name>Q5ADW1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C307600WA</name>
        <name evidence="3" type="ordered locus">orf19.14022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719829.1">
        <property type="nucleotide sequence ID" value="XM_714736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADW1"/>
    <dbReference type="SMR" id="Q5ADW1"/>
    <dbReference type="FunCoup" id="Q5ADW1">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADW1"/>
    <dbReference type="GeneID" id="3638495"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307600WA"/>
    <dbReference type="CGD" id="CAL0000193391">
        <property type="gene designation" value="orf19.14022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07600W_A"/>
    <dbReference type="eggNOG" id="KOG4829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067161_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ADW1"/>
    <dbReference type="OMA" id="ISKWNTQ"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000193391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="216" mass="25305" checksum="9782A6C2431A6E0A" modified="2005-04-26" version="1">MSSVPAWKRAGLSVKAQQQQEDEDSLTTKRIENADLTVKEIKKISNKRKLQDDTKHKSKKPPKRIKLPKNERPPPPVKDQLTYLKQFVDDKENWKFNKSKQNWILKNIKNIPKEYEEALILYLGTLQGGSRDRIIPELKEVISKWNTQYEEAERKIEEELTKKVENEIDKDSKTSNDAENKEQKEEEKDAVDLEYALRCRAILSKLTDEDIEVKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEJ1</accession>
    <name>Q5AEJ1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">THI6</name>
        <name evidence="20" type="ordered locus">CAALFM_C302860WA</name>
        <name evidence="19" type="ordered locus">orf19.7909</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719975.1">
        <property type="nucleotide sequence ID" value="XM_714882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEJ1"/>
    <dbReference type="SMR" id="Q5AEJ1"/>
    <dbReference type="FunCoup" id="Q5AEJ1">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AEJ1"/>
    <dbReference type="GeneID" id="3638333"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302860WA"/>
    <dbReference type="CGD" id="CAL0000179143">
        <property type="gene designation" value="THI6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02860W_A"/>
    <dbReference type="eggNOG" id="ENOG502QS2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AEJ1"/>
    <dbReference type="OMA" id="GQTDMPI"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000179143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW28317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="514" mass="55448" checksum="04FE09B0ACA0424B" modified="2005-04-26" version="1">MTLSKMKVDYTLYLVTDSGMVPESSSFLKQVEDSINSGATIVQLREKSLSTLEFIKRAEQVHKLTQKQGIPLIINDRVDVALAVNAEGVHVGQDDMPAAIARKLIGDDKILGVTCSNVTEVQEVVEQGIADYVGLGTVYKTNTKKDVTDPEGTGPSGIRRMLRVLQKHNSKSGAKKIQSVAIGGINHSNVRNVMFQCAVPGEKINGVAVVSCIMANENAAEATLSLSQLISSAPYGYEPYEESQYLDDYQHSLKQLSSSSPMIHHITNNVVKNFSANVTLAIGASPIMSEFDEEFNELASTPNTALVLNLGTPSKEMMKIFKNSIIAHQSRNPIVFDPVGCGASKGRLECCRQLLDTGYFAVIKGNVGEISALRKLTSSYRESQSKSYMRGVDSISNLTEEEIIEIGKDVSIEFKAVVVITGPTNYIIEGEDKVVKVEGGNKLMGSITGSGCALGSTIAAFVSSQARSPQGPNNFYAAVHAVKLYNKAGAAVSEKTPGKFMASFIDELYKLTHS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-05-10" modified="2025-02-05" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AG77</accession>
    <accession>Q8TGV8</accession>
    <name>GAP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Amino-acid permease GAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GAP1</name>
        <name type="ordered locus">CAALFM_C502790CA</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Microbiology" volume="149" first="2597" last="2608">
            <title>N-acetylglucosamine-inducible CaGAP1 encodes a general amino acid permease which co-ordinates external nitrogen source response and morphogenesis in Candida albicans.</title>
            <authorList>
                <person name="Biswas S."/>
                <person name="Roy M."/>
                <person name="Datta A."/>
            </authorList>
            <dbReference type="PubMed" id="12949183"/>
            <dbReference type="DOI" id="10.1099/mic.0.26215-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Mol. Microbiol." volume="50" first="993" last="1004">
            <title>Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1.</title>
            <authorList>
                <person name="Limjindaporn T."/>
                <person name="Khalaf R.A."/>
                <person name="Fonzi W.A."/>
            </authorList>
            <dbReference type="PubMed" id="14617156"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2003.03747.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="1076" last="1087">
            <title>Transcriptional response of Candida albicans upon internalization by macrophages.</title>
            <authorList>
                <person name="Lorenz M.C."/>
                <person name="Bender J.A."/>
                <person name="Fink G.R."/>
            </authorList>
            <dbReference type="PubMed" id="15470236"/>
            <dbReference type="DOI" id="10.1128/EC.3.5.1076-1087.2004"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="54" first="1335" last="1351">
            <title>Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p.</title>
            <authorList>
                <person name="Bensen E.S."/>
                <person name="Martin S.J."/>
                <person name="Li M."/>
                <person name="Berman J."/>
                <person name="Davis D.A."/>
            </authorList>
            <dbReference type="PubMed" id="15554973"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04350.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1219" last="1229">
            <title>The Candida albicans GAP gene family encodes permeases involved in general and specific amino acid uptake and sensing.</title>
            <authorList>
                <person name="Kraidlova L."/>
                <person name="Van Zeebroeck G."/>
                <person name="Van Dijck P."/>
                <person name="Sychrova H."/>
            </authorList>
            <dbReference type="PubMed" id="21764911"/>
            <dbReference type="DOI" id="10.1128/EC.05026-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2013" name="MBio" volume="4" first="E00637" last="E00637">
            <title>Regulatory role of glycerol in Candida albicans biofilm formation.</title>
            <authorList>
                <person name="Desai J.V."/>
                <person name="Bruno V.M."/>
                <person name="Ganguly S."/>
                <person name="Stamper R.J."/>
                <person name="Mitchell K.F."/>
                <person name="Solis N."/>
                <person name="Hill E.M."/>
                <person name="Xu W."/>
                <person name="Filler S.G."/>
                <person name="Andes D.R."/>
                <person name="Fanning S."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="23572557"/>
            <dbReference type="DOI" id="10.1128/mBio.00637-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2016" name="MSphere" volume="1" first="0" last="0">
            <title>Characterization of the Candida albicans amino acid permease family: Gap2 is the only general amino acid permease and Gap4 is an S-adenosylmethionine (SAM) transporter required for SAM-induced morphogenesis.</title>
            <authorList>
                <person name="Kraidlova L."/>
                <person name="Schrevens S."/>
                <person name="Tournu H."/>
                <person name="Van Zeebroeck G."/>
                <person name="Sychrova H."/>
                <person name="Van Dijck P."/>
            </authorList>
            <dbReference type="PubMed" id="28028545"/>
            <dbReference type="DOI" id="10.1128/MSphere.00284-16"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 9 12">Amino-acid permease that coordinates external nitrogen source response and morphogenesis (PubMed:12949183, PubMed:21764911, PubMed:28028545). Is capable of transporting several structurally unrelated amino acids such as leucine and phenylalanine, though with a lower capacity than the GAP2 and GAP6 permeases (PubMed:21764911). Has citrulline import activity (PubMed:12949183). GAP1 is also able to transport thialysine, and thus probably also lysine (PubMed:21764911). Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 12">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 6 7 8 10 11 12">Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545). Expression is induced by N-acetylglucosamine (PubMed:12949183). Expression is also regulated by CPH1-mediated RAS1 signaling but is independent of EFG1 (PubMed:12949183). Induced during biofilm development (PubMed:21414038, PubMed:22265407, PubMed:23572557). Induced upon internalization by host macrophages (PubMed:15470236). Expression is down-regulated by growth in alkaline conditions (PubMed:15554973). Expression is also controlled by the nitrogen-dependent GATA-type transcriptional activator GAT1 (PubMed:14617156).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Decreases two fold the citrulline uptake (PubMed:12949183). Leads to defective hyphal formation in solid hyphal-inducing media and exhibits less hyphal clumps when induced by N-acetylglucosamine (PubMed:12949183).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720611.1">
        <property type="nucleotide sequence ID" value="XM_715518.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AG77"/>
    <dbReference type="SMR" id="Q5AG77"/>
    <dbReference type="STRING" id="237561.Q5AG77"/>
    <dbReference type="TCDB" id="2.A.3.10.23">
        <property type="family name" value="the amino acid-polyamine-organocation (apc) family"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AG77">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C5_02790C_A-T">
        <property type="protein sequence ID" value="C5_02790C_A-T-p1"/>
        <property type="gene ID" value="C5_02790C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637806"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502790CA"/>
    <dbReference type="CGD" id="CAL0000177621">
        <property type="gene designation" value="GAP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02790C_A"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="Q5AG77"/>
    <dbReference type="OMA" id="VSQCGVW"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000439806" description="Amino-acid permease GAP1">
        <location>
            <begin position="1"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12949183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="14617156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15470236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15554973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="21414038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="21764911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="23572557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="28028545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="582" mass="63951" checksum="72CC98F97D0E4053" modified="2005-04-26" version="1">MLHKKETNDTFVQLNRSPSTGEQKSSGIWSSIKDSFKPALPQDKLTGVDDIPDRELTDIERININAANSNLQRKLKTRHLQMIAIGSSIGTGLFVGTGGALSTGGPAAIVLAWAISAISVFMTMQGLGELAVAFPVSGGFNLYASKFLEPGIGFAVGWNYFLQFFVLLPLELVAGAITIKYWNASINSDVFVIIFWFVVLVITMLGVRWYGEAELVFCTIKVIAVIGFIILGIVLICGGGPNHEFIGGKYWREPGPFANSFKGFASSLITAAFSFGGTEMIALTASESSNVRHALPKAIKQVFWRIVIFYLGSIIMIATLVPYNDKRLLGSSSVDVTASPFTIAIVNGGIKGLPSVINAVILISVLSVGNASVYATSRTLNSLAEQGMAPKWTGYIDRAGRPLFAILITNVFGLFALIAADNEKQVVAFNWLLALSGLSSIFTWMSINLSHIRFRRAMKVQNRSLTELPFVAQSGVWGSYFGLTLNILYLIAQFYIGLFPVGGKPNAYDFFLAYLGVPVILASWIGYKIWKRDWTLFIRAKDIDLDTGRINVDLDLLQQEIAEEKAQLAEKPFYIRIYRFWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGB0</accession>
    <name>Q5AGB0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C502560CA</name>
        <name evidence="5" type="ordered locus">orf19.11745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720577.1">
        <property type="nucleotide sequence ID" value="XM_715484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGB0"/>
    <dbReference type="SMR" id="Q5AGB0"/>
    <dbReference type="GeneID" id="3637719"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502560CA"/>
    <dbReference type="CGD" id="CAL0000188870">
        <property type="gene designation" value="orf19.11745"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02560C_A"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_4_1"/>
    <dbReference type="InParanoid" id="Q5AGB0"/>
    <dbReference type="OMA" id="DVMTTMV"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="195"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000188870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="584" mass="67942" checksum="CE9ED4B3DBEAA572" modified="2005-04-26" version="1">MFRQSLIYMNRPKKSVKSIYFHRYMNTKIPITSFKPINPRPKPKPKPKPKLKFKLKPQGKFRPLVYGVAIVATGLGTAYYIDNHYYSSLMTRSVRAVYVLLWIAYAYGFNSNSYQNIDDLHEIASDKLLHLLTTNKGLYIKLGQAIANQGNLFPLAYQKKFPQLYDQAPVQSWQDIDRILKENLGDDYQIRLFETINHEPIASASIAQVHYGKLKNGEEVAIKVQHGYIEKQVVVDLMIYRFISKVYEKVFDIPLSMFTKYISEQLIKETDFVHEMQNSEKLKKFIDKDSSLKYDNIKLPKNYPHLTTKQVLTAEWINGIPLTNKQTLLDQNYDLTLIMKQYIKLFGRQIFEYGFIHSDPHPGNLLVRFDSKNKQQLVLIDHGLYITLSDSFRLQYCNLWRYLFSLNTKGIEQIGREWGISSIDLFATVVQLRPVLLSPEVQSNANANANANKNEDEDNRNISDLFRDFIGDQKKFPGELPFLSRTMRMIQNLNQSFGSPVNRINLLTKESINALLQEKDLKFGNYWDLVRIKITLLLSGFMFYIVRLRQILSGDRFGGKGKGLEDYIEMYMQNTAKSLGMEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGX8</accession>
    <accession>Q3MPH7</accession>
    <name>Q5AGX8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LAT1</name>
        <name evidence="12" type="ordered locus">CAALFM_C701640WA</name>
        <name evidence="11" type="ordered locus">orf19.13914</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="7">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721397.1">
        <property type="nucleotide sequence ID" value="XM_716304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGX8"/>
    <dbReference type="SMR" id="Q5AGX8"/>
    <dbReference type="FunCoup" id="Q5AGX8">
        <property type="interactions" value="1148"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AGX8"/>
    <dbReference type="GeneID" id="3636986"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701640WA"/>
    <dbReference type="CGD" id="CAL0000189879">
        <property type="gene designation" value="LAT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01640W_A"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="InParanoid" id="Q5AGX8"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000189879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="477" mass="50062" checksum="944DAE53549CB9AB" modified="2005-04-26" version="1">MSALFAVSRSAIALRSIAPRSSTATTSSFLALARLYSSGKFPPHTVINMPALSPTMTQGNIQSWAKKVGDELTPGEAIAEIETDKASMDFEFQEEGYLAKILLDAGAKDVPVGQPIAVYVEDAGEVAAFENFTAADAGEAPKPAPAAEEEAPKKEEPKASTSTSAPASTPSPSSKKAPTDRIIASPFAKTIALEKGISLKGIKGSGPNGRIVAKDLEGVEPQAAAAAAPAAAAATAGAAPSATASYEDIPITSMRKTIASRLLQSTQQSPSYIIQSQISVSKLLKLRASLNATAEERYKLSINDLLIKAIAKTCVRIPEVNAAWLGEQGVIRQYKNVDVSVAVATPTGLITPIVTNAESKGLAEISNQVKDLGKRAKVGKLLPEEFQGGTICISNLGMNHAVTAFTSIINPPQSAILAIGTTEKKAVPSEVNEQGFVFDDVITITGTFDHRVIDGALGGEWMKELKRIVENPLEMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AHZ1</accession>
    <name>Q5AHZ1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">IMP1</name>
        <name evidence="12" type="ordered locus">CAALFM_C103610CA</name>
        <name evidence="11" type="ordered locus">orf19.10579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721559.1">
        <property type="nucleotide sequence ID" value="XM_716466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AHZ1"/>
    <dbReference type="SMR" id="Q5AHZ1"/>
    <dbReference type="FunCoup" id="Q5AHZ1">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AHZ1"/>
    <dbReference type="GeneID" id="3636881"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103610CA"/>
    <dbReference type="CGD" id="CAL0000180500">
        <property type="gene designation" value="IMP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03610C_A"/>
    <dbReference type="eggNOG" id="KOG0171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="InParanoid" id="Q5AHZ1"/>
    <dbReference type="OMA" id="LCKGPSM"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000018">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000180500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="183" mass="20587" checksum="5776F94EA81486AD" modified="2005-04-26" version="1">MTFFESLKFVGSTLSWTLRAGCIAHLIHENVYEFTETRGESMLPTLQNQHDYVHALKKYKYGRNLVMGDCIVAIKPSDPSHRICKRITGMPGDMILVDPSSSSELTNSPNEIIQHDGYNKYIRIPEGHVWCTGDNLCHSLDSRSYGVVPMGLITGKIVAANSMSEGISTLYNFRWITNTLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AJ72</accession>
    <name>Q5AJ72_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C301310WA</name>
        <name evidence="12" type="ordered locus">orf19.9288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721791.1">
        <property type="nucleotide sequence ID" value="XM_716698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AJ72"/>
    <dbReference type="SMR" id="Q5AJ72"/>
    <dbReference type="FunCoup" id="Q5AJ72">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJ72"/>
    <dbReference type="GeneID" id="3636620"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301310WA"/>
    <dbReference type="CGD" id="CAL0000196701">
        <property type="gene designation" value="orf19.9288"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01310W_A"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="InParanoid" id="Q5AJ72"/>
    <dbReference type="OMA" id="WNICRID"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140750">
        <property type="term" value="F:nucleosome array spacer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002722">
        <property type="entry name" value="ATP-dependent DNA helicase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="187"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="615"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000196701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="864" mass="99608" checksum="D196F8AF7A4C2FE2" modified="2005-04-26" version="1">MTTSPPIQDDEQDEEFKLKQIIKEQNLIPQINSHNHDDVASEQQQQQFNQLSKDKKMNRLNKLIEKSQIYSQIIADNILQTSLERKEEQNNVAPPAPVPAKSDSKNESDTQPIKKRRKTKPKSKSTANGKQDIVSMLSTNISDSTKSTREAIEKSQNSSKITNNKQPKLITGGQLKDYQMDGLEWLITLFQNGLNGILADEMGLGKTLQCISFLSHLIENGINGPFLVVVPVSTLSNWYNEIRKFAPKIKVTKYIGTKQERNDIDLLQQQETTNIILTSYEISIRDFNKLVKINWKYLIVDEGHRLKNSQCLLIKILKKLNVSNRLLLTGTPLQNNLNELWSLLNFILPDIFHDLELFQQWFNFDELTELAGELEGTNNEEDEETKNLIKLNIQETLIKNLHTILKPFMLRRLKRDVIKNLPPKKEYLLHIPMTKLQKKIYYDAVNDKLFDSLVETNLKAFIKFNHEELFNGFDVDEYLKTRRQRDSFMETGGLSKLRGSRSDRNSLKRSYKEADSDEEFEIMDAEDDSLTGRGNTTPSYDEALVKIRHIKSKTKIQSILIDAIYQDILKEAKHLKLQNLKMIQLRNICNSPFIYYNYPILDQAEVIRNSAKFQVLNQLLPPLLSSGHKVLIFAQFTKVLDLLEDWLEESPLSHGKICRLDGSTNHQIRDEQISQFNNNPKFKVFLSSTRAGGLGINLVAADTVILMDNDWNPQMDLQAIDRVHRIGQINPVKIFRFVIKDSIEEVLISRSGSKRFLERLVIQMGQFKFSNFNKKLTAATTSNEQGAIKNDWSINDMMELSKIHFKSTQNGQTSQDSAEEDEKILLSDQEIDELLDRSVECYNSIDDSKFDKVKIFETVNNMDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2025-06-18" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKU4</accession>
    <accession>A0A1D8PFT8</accession>
    <name>ATG12_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG12</name>
        <name type="ordered locus">CAALFM_C113950CA</name>
        <name type="ORF">CaO19.12500</name>
        <name type="ORF">CaO19.5033</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722235.1">
        <property type="nucleotide sequence ID" value="XM_717142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKU4"/>
    <dbReference type="SMR" id="Q5AKU4"/>
    <dbReference type="FunCoup" id="Q5AKU4">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AKU4"/>
    <dbReference type="EnsemblFungi" id="C1_13950C_A-T">
        <property type="protein sequence ID" value="C1_13950C_A-T-p1"/>
        <property type="gene ID" value="C1_13950C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636186"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113950CA"/>
    <dbReference type="CGD" id="CAL0000188918">
        <property type="gene designation" value="orf19.12500"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13950C_A"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106795_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AKU4"/>
    <dbReference type="OMA" id="DLPMNMS"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="PRO" id="PR:Q5AKU4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000212475" description="Ubiquitin-like protein ATG12">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-148 in ATG5)" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="164" mass="18058" checksum="FE96477B6823E062" modified="2005-04-26" version="1">MSRIIHSEDDDDDDVGSQSSSSLSSPSKSLQQDPIPTKIPLSTSIILEKKLPLEQHQKLSNLTEGSTAGGHVSNNSLDNKIMIRFVPIGSTPSIQPRVFKISATQTVSTLNRFLCKKLKFKGVLNLYIQNSFMPLPDEQIGSLYGLFKTNNELIISYCNTIAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMQ3</accession>
    <name>Q5AMQ3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rga2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">RGA2</name>
        <name evidence="10" type="ordered locus">CAALFM_C402000CA</name>
        <name evidence="9" type="ordered locus">orf19.12062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722665.1">
        <property type="nucleotide sequence ID" value="XM_717572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMQ3"/>
    <dbReference type="SMR" id="Q5AMQ3"/>
    <dbReference type="FunCoup" id="Q5AMQ3">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="IntAct" id="Q5AMQ3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="MINT" id="Q5AMQ3"/>
    <dbReference type="STRING" id="237561.Q5AMQ3"/>
    <dbReference type="GeneID" id="3635661"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402000CA"/>
    <dbReference type="CGD" id="CAL0000179204">
        <property type="gene designation" value="RGA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02000C_A"/>
    <dbReference type="eggNOG" id="KOG1453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003874_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AMQ3"/>
    <dbReference type="OMA" id="RYAKTKR"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="712"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="935"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000179204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131153" checksum="38225B9B9AB0C50A" modified="2005-04-26" version="1">MPELVPPTNNRPHIHETPELSSQPSLDSNRQPRELCKKCNQLIVEGHAYELGDDRWHIHCFNCSKCNTSLGCNSNFLVLGNGNLICSNCSYNCKQCGRKIDDLAILTGDQAYCSNCFKCRSCKNKIEDLRYARTSKGLFCMDCHQKLMAKKKKYDAKKKHLALLQEKRVQLEREKDQRELQILEDHKRSVNSSRNSLIQSYMNNQNNQSGESLLYQQNNRSVTSVTSSKNKSLPLPPTSTSPARPTPYSANSYQSKESISGKNKTDTSLGSLSTSQTFSEHTNKGGSTMHSSTGLHNPPIFQSDNDFSIEEVQNSSDSDSNGDEKKSNSTSLRNKSSNRNSRVSPFVNQYSTPPLSSDHLNTDEISADTGERTVYLDVIDTPPESQADPLAGNQLKPALDVSPGRNTEQKSKSFLILSPNQFHDNEFHNTRSPMIDSPGTIISSNSNQNTKAVNLSVEDRPRSACPSPFAKVNRQARVVETNDEISTDGVDEDLAIGTPRQEHSRAGTLKSVSSPPPKVPLPSTPSRGEDISKKFSFVETPKGLGLEGVDYDNHEDQRSYIKSQQDQRQHDISEKTSPSSIMSTPKRVVGNFSPAVTNLEPKNSDLSNDQQHKHSQKNQNVSRTASLIKNLKHKRSTSGNQNKLAALFTTGSKEDHRNGHTRQTSDGSLFSSIANAYISPPITNGALGGRNHIRSTSDSTVLLSDEDHHYSNVAVKNDIEQLNSSKVLLEEDVKKLRDERHKLNEQLKMIQSKISSESIRYDNLVAEISELQIQKTKITNENKDLIEQQKNRQASGATGKLSTSSSNDSDPDASTLGKSVNTHLSPYKSSSDSTSVVSRENFEYSDHLSPDRHQGQFQQHQQYQQQYQQQQPQQQLIEDEQAHKATRLKFWRRPKVGTTQVISSNEYNNNGNGHNNGARIPNSFSTQALRIPAHNSGSSFNNNGANNNNQQNKFSKSKSSNVLDSLLSGDSSQVPLFNSTLQQRAEYEKSQVPIIITRCLAEVEKRGLDFEGIYRISGGNSAIVSIENAFSSLSNDPDEKQLNRVDETLDVDIHAVTSALKRYLRKLPDPVIPFDLYDDFIKVSTKASHSKEVRIAELQKIVNKLPPANRETLRLIVNHLHLVNSLKDINKMGYKNLSVVFAPTLAKDESGVKEMTDMGFRNDTTELLLTESHRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANN9</accession>
    <name>Q5ANN9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kre9p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">KRE9</name>
        <name evidence="8" type="ordered locus">CAALFM_C304180WA</name>
        <name evidence="7" type="ordered locus">orf19.13283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell wall beta(1-&gt;6) glucan synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRE9/KNH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723077.1">
        <property type="nucleotide sequence ID" value="XM_717984.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANN9"/>
    <dbReference type="FunCoup" id="Q5ANN9">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANN9"/>
    <dbReference type="GeneID" id="3635183"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304180WA"/>
    <dbReference type="CGD" id="CAL0000200786">
        <property type="gene designation" value="KRE9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04180W_A"/>
    <dbReference type="eggNOG" id="ENOG502S28F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063732_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ANN9"/>
    <dbReference type="OMA" id="YYYFQIY"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971245" evidence="4">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="5">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000200786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="271" mass="29116" checksum="FB04E223F26AFDFF" modified="2005-04-26" version="1">MRQFQIILISLVVSIIRCVVADVDITSPKSGETFSGSSGSASIKITWDDSDDSDSPKSLDNAKGYTISLCTGPTSDGDIQCLDPLVKNEAISGKSKTVSIAQNSVPNGYYYFQIYVTFTNGGTTIHYSPRFKLTGMSGPTATLDVTETGSVPADQASGFDTATTADSKSFTVPYTLQTGKTRYAPMQMQPGTKVTATTWSMKFPTSAVTYYSTKAGTPNVASTITPGWSYTAESAVNYASVAPYPTYWYPASERVSKATISAATKRRRWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5API4</accession>
    <name>Q5API4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C109220WA</name>
        <name evidence="5" type="ordered locus">orf19.12244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723466.1">
        <property type="nucleotide sequence ID" value="XM_718373.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5API4"/>
    <dbReference type="STRING" id="237561.Q5API4"/>
    <dbReference type="GeneID" id="3634898"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109220WA"/>
    <dbReference type="CGD" id="CAL0000188365">
        <property type="gene designation" value="orf19.12244"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09220W_A"/>
    <dbReference type="eggNOG" id="ENOG502QTZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_1"/>
    <dbReference type="InParanoid" id="Q5API4"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000188365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="457" mass="49746" checksum="5890C24401353EAA" modified="2005-04-26" version="1">MSEGWISFLIDEIGLYTLSNAGTDVYIIILLRMIRLIGFGATSLILALFLKSLGIPEQYIGLFMTLTFIGDLVSSFLLSIITDQIGRKKMLLACSVLMTLTGAVFGSFENYYVLVITAILGILTPSGGEVGPFRTVEQSSIASLVPHEKRSDIYAWYTFLGTFCAAFGSFLAGALIDIVQDNYGFTIVQSYKCVFWVYTLLSGICVILCLFITGNIEVKPDPGLEEPATTPEDNESEPTETSQLIPTTGNVTNKPKNKFRLLPHLSPDTYLLVIKLSLLFGLDSFASSLTPISWISYYIKNKFDVPSSYLGSVFFTTGFVSGFTSLGSTPLTKRFGAVVTMVFTHLPASILLALVPLPSSFSLTMGILVVRACTQTMDVAPKHVFLATLVSDSDRTAVFGFVNVVKTLAQVVGPSIVGVITQRGAQWISFVIAGSLKATYDIGMLVTFLTYNRHAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCW2</accession>
    <name>A0A1D8PCW2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hol1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">HOL1</name>
        <name evidence="9" type="ordered locus">CAALFM_C103000WA</name>
        <name evidence="8" type="ordered locus">orf19.10508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Scherer S."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
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        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C105280WA</name>
        <name evidence="8" type="ordered locus">orf19.8068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="AOW26198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_710780.2"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1D8PDJ2">
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG2417">
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    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="ABA_GPCR_dom"/>
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        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15948:SF0">
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    </dbReference>
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        <property type="entry name" value="ABA_GPCR"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <end position="25"/>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
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    <dbReference type="CGD" id="CAL0000201841">
        <property type="gene designation" value="orf19.9992"/>
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    <dbReference type="eggNOG" id="KOG2276">
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        <property type="entry name" value="Zn peptidases"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01546">
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="867"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
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        <location>
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            <end position="374"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
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        </location>
    </feature>
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            <end position="131"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="372"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000201841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1131" mass="126965" checksum="88B5978412C8CC84" modified="2017-01-18" version="1">MTSPNNTSSNFNIHESEYLSQDRKPLPLSSTPSTENIILTPRTHTPIRLNSPHINMAELAIHNNQKQQQQQQQQQQQRSKQSSPLFFSDTKVSGPGTVATMASITTPHCQHHQPQFSTFSQIPNTSSKPTSQLPPASALSSSPLEMPITTTPSYYNPQDLNDNDNHSINNDNNLPRLVHKWSHTHSILCCLASPKNRLLFCGTQDGKILVYDMNTYTLTHIIGNENNNTNTEDHHPHHQSASILTICLNKDETKLFVAGSDSLVKIYNLQKNPNGSDDDKKYQCTHVIYSLVDIGDIFSIHWCDSTSTIYIGAQNASILWCHISFDNEDLVTNGDNKKQPSNGINHKHKHKQSSQHQNNTNHHQQTHRNINNGCNDTKNILDIERLPHFRYDKFFDSKGPGGSQNTLQTTHNLLKRRYSKTTNESKHHSSIKLIECKSDDIIRFAHNGYVYCLDVITNATISDSSESNFLISGGGDGIINIWSFNHNPTIGVKLIKVASLENDESILSMKIQDSLLYVGLSDCSINVWDLLTLQLIRSFQFGDNNFDEILSLDIYDNCIYKGSSSTGLIKLSILNHQFISDKILMSSEIEDGVINAVKIFPSDDDKIYLLSGASKSLSLWDITTSKSTTNQRHDKNLNDDEEQEQEQEQEQELLNGELHKKLSNDDMLIMLQKYVAFKTISKNPQLYLEESRHCAQFLCKLFNNFGAYQTKLLPISNGNPIVFSEFKANSTTNGTGNARRPRLLWYAHYDVVDATKNEAKDWKTDPFILTAKEGNLYARGVSDNKGPTLAAIYSVAELYHRQQLNCDVVFIIEGEEECGSIGFQKVINDNKQLISGGSGGGNGTTGIDWIMLSNSYWLDDLTPCLNYGLRGVINASITIKSDKPDRHSGVDGGVSREPTMDMMHLLSTLVDPITRKIQLPGFYNDILPLTSSEKKLYDTIAQYSGIKVSTLMTKWREPSLTIHKIQVSGPNNNTVIPQIVKATISMRIVPNQDLSKIKQSLIDTLNENFAKLSSSSSSSMDTTTNSITGNKLSVEIFHQAEPWLGDHENKVYSILFKNLKNHWNQEPLFIREGGSIPSIRFLEKCFNAPAAQIPCGQSSDNAHLKDEKLRIINLFKLRAILTDTFKELGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE78</accession>
    <name>A0A1D8PE78_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin-alpha export receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C107690CA</name>
        <name evidence="9" type="ordered locus">orf19.8815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716539.2">
        <property type="nucleotide sequence ID" value="XM_711446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE78"/>
    <dbReference type="SMR" id="A0A1D8PE78"/>
    <dbReference type="FunCoup" id="A0A1D8PE78">
        <property type="interactions" value="1245"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PE78"/>
    <dbReference type="GeneID" id="3641767"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107690CA"/>
    <dbReference type="CGD" id="CAL0000195471">
        <property type="gene designation" value="orf19.8815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07690C_A"/>
    <dbReference type="eggNOG" id="KOG1992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE78"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001676">
        <property type="entry name" value="Importin-alpha export receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000195471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1045" mass="119203" checksum="F7C256A88C9CA6B1" modified="2017-01-18" version="1">MSQNNLETIPKILEQSLHPQFSNQADKILKSIENEPGFSINLLHVIASTNLSQSIRLAGALYFKNLIKRKWLDGDGDGNNYLLPIDDVNKIKLEIIDIMIQLPNQLQVQIGEAITLIAESDFPHNWPNLIENLVTKFSLTNFINNKAILLVSHSIFKKWRALFRSDELFLEIKLVLTKFVDPFLKLFIELDQLIDKSSDNEAQLIIYFENLLLLVQIYYDFNCQDIPEFFEDHMNELMAIIHKYLVYENGLLKYHDNDEEVNVLIKVKTSIVELLSLYITRYADVFQPLIQTFITSVWELINNYVTKQPKYDLLVVKSLQFLTSIIKIPDYQSLFQQESSINEIIEKIILPNIYFRENDEETFEDEPILYVRSDLEGSDYDSRRKSATDFLRELKELNSELLTTTVMKYVNQFLNQSTNHSDWRNKDTAIYLFSSLATKGSVTNIGVTSTNVLVDVVKFFSDNIANDLATTTTTTTTTNTGATSVHPILQVDAIKYIYIFRNQLTKEQLMMTLPRLIDHLDIKSNPVVYTYSAITIEKLLSMTNFNQDHTPIFNKTDIQPYINELLTNLFNLICINNNNNNNNNNNNSSPEKLAENEFLIKCIMRILNTGEDSLNENNRFPIINQLLTILKLTAKNPSNPKFSHYIFESLGLLIKYGINDNDNDNNAANQYIEIIIPALLDILSEDVQEFVPYTFQILAFLLEKYPKQQGLPETYKNLIQPLLSPSVWQFRGNIPGITRLLIAILEHDPNSTFINGGEKTLTPLLGVFQNLLASKINDGYGFDLIQSIMLNIPIQPSLQSFLPNIARLMLTRLQKSRTDKYVKRFVTFLCLLSTISLQGTTTTTTTTTTTNVNKDILNGEFVIQFLESVQSGLFQQILTSFILPTSSILTNLQDKKLVNIGLSQILVTISTTSEQYAHLTPLILETLISNLNSYEGISKSSTNNNNNGISSSSSTIATTISGGQQPLNELDLDLDLNFNFNSFGSQYSKIVSIQNSSFDPLNNLIKNNDFNNIKLIIFNNIKKIDIKYLYGLNSTNQEILKKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEC5</accession>
    <name>A0A1D8PEC5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">MED15</name>
        <name evidence="8" type="ordered locus">CAALFM_C108270CA</name>
        <name evidence="7" type="ordered locus">orf19.12571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717642.2">
        <property type="nucleotide sequence ID" value="XM_712549.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEC5"/>
    <dbReference type="SMR" id="A0A1D8PEC5"/>
    <dbReference type="STRING" id="237561.A0A1D8PEC5"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PEC5"/>
    <dbReference type="GeneID" id="3640761"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108270CA"/>
    <dbReference type="CGD" id="CAL0000193033">
        <property type="gene designation" value="MED15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08270C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PEC5"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEV1</accession>
    <name>A0A1D8PEV1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YTP1-like C-terminal domain-containing protein</fullName>
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        <name evidence="7" type="ordered locus">CAALFM_C110360CA</name>
        <name evidence="6" type="ordered locus">orf19.12373</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW26666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718496.2"/>
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        <property type="gene designation" value="orf19.12373"/>
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    <dbReference type="eggNOG" id="ENOG502QW3E">
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="DUF2427"/>
    </dbReference>
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        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF2427"/>
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        <property type="entry name" value="Ytp1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="604"/>
        </location>
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            <begin position="106"/>
            <end position="127"/>
        </location>
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            <begin position="139"/>
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        </location>
    </feature>
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        <location>
            <begin position="26"/>
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        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000189087"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AOW26666.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="68958" checksum="5D0701E7E6289712" modified="2017-01-18" version="1">MKPIALLLVLFTSLSLADMNMDSHSDMMSGSHHNEDVDSLESMPTSTENTDNINSTESLVPIPHVMKHMHGVPILQTKLLPQERLFWENYNTTTYFTVESAHRPALYLHIAVGLFSVFVFYPISLIFNNLNMGKSYMTMLLIHSSCIVFSLLNYSIFINSIPDLYPGNAYNSMVIILFVTTILQLIFAFIKNIEPGESDGNKYFQLNNQHMRANSSDEESLQSMISPPSTDDVIPSEKPSSSKMSNFYDKVMKFRTWVAQTKFYKISKIGFNLLNWGHFFYFLILVPTGVATFCCYGKGNTVFNLLAHFIKGGVFFAYGLLSLSRYCGGFTNKGWAWNHKFIDRTKKQSFWFSLQNKGLWTMEMIESSLILFYGSTNIFLEHLANAGGEWSPKDLQHASIAFIFIGCGLCGVITELKLQDWRYEQAMADMEKYQYQGEEQNQQELQSNTNNNNTIIKASPGFSPNPFPIVTIYWTGILMSKHQQASSLSTEVHVQWGNMFVLGCAFRFITYLMLMLNAKVPKDLSRPSRPFTELVVSFSLLCGGLIFMESTDPVILSFEYYGLTSMFTLNISLGFTTLFMGWQMLLFAFKDWLKSKYNKQQDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG31</accession>
    <name>A0A1D8PG31_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C200410CA</name>
        <name evidence="11" type="ordered locus">orf19.9637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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    </reference>
    <reference evidence="12 13" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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        </reaction>
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        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGN2</accession>
    <name>A0A1D8PGN2_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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        <name evidence="7" type="ordered locus">orf19.9155</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Nantel A."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGN2"/>
    <dbReference type="STRING" id="237561.A0A1D8PGN2"/>
    <dbReference type="GeneID" id="3635858"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202570WA"/>
    <dbReference type="CGD" id="CAL0000189672">
        <property type="gene designation" value="orf19.9155"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02570W_A"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGN2"/>
    <dbReference type="OMA" id="WLTIMAY"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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    <sequence length="553" mass="62200" checksum="F133DC870DB2A459" modified="2017-01-18" version="1">MFDKEINEIPEYEMVPGTVQLVDVTGTLEVEKNGDKSNIILQPPPSKNINDPLRWSKRKRRIQFFLLFIWSFLQSSTSNFTGPLYDAFVEALDVTYQDISNTAALCFTGLGLGVIIIQPCAAKYGKRVVYLTCTLIAIIGCIVGGTGKNLASLYIFNFLSGLGASPVDSIAEVSANDLHFQHERSTALSVIIMALYFGSFLSPVAAGYITANPHLGWRWCFYVQIIIYAVLFIFMFFVLEDTTFTRDSKKEDEFEEHILQQVQSMRSKDNVDVILSSSASVKTEENESVDESTIPKKTYWERMKLIHTEYGDRRSWLLIFVRPAFLAYFPAIIWSSCAYGAQMMWLSLMGNTQTLFYASEPYNFTADKVGLTNLAPFVGVVLGMLYGGRFVDWFSLQKAKRNFGISEPEHKLWTMIVPLLFNAAGLIAYGLGPYYGAHWAISVIIGQGFLGFAMAASGTLCLTYGAFDCYHKLAGESVVLILFIRNMFGMIFCFACQPWIDNSGVFWTTITMCVLSIVINGGFAILLVWGKTFRKWTAEPYERYSDSNYGNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="130" mass="14462" checksum="8C21AC91CA03B7D8" modified="2017-01-18" version="1">MSSDSSSPETTTISEQNTTTNETGTGKQGRKKTKSSVLSDEQKKAHHIASEQKRRENIRAEFDKIVSLTPNLNESENRSELNILTKSADYIDELRAENIKLIEICRQKGISIPPELIYSGPKNDGSDIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHK1</accession>
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        <name evidence="4" type="ordered locus">orf19.12679</name>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330785.1">
        <property type="nucleotide sequence ID" value="XM_019475240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHK1"/>
    <dbReference type="SMR" id="A0A1D8PHK1"/>
    <dbReference type="FunCoup" id="A0A1D8PHK1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHK1"/>
    <dbReference type="GeneID" id="3647475"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205900WA"/>
    <dbReference type="CGD" id="CAL0000188598">
        <property type="gene designation" value="orf19.12679"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05900W_A"/>
    <dbReference type="eggNOG" id="KOG4739">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHK1"/>
    <dbReference type="OMA" id="NTQMATH"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000188598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="366" mass="41789" checksum="DA9077D350AAD3FC" modified="2017-01-18" version="1">MNQEFDQNSPYIYCGICFKDNHDVEGLDNKLLLTSCAHITCDIHLQSKHIESYLAQNDSDSPCPVCGSNPISTVPINRMLPVELKNFFIPTPQQIDLLTSSGKFQYCSLVDRINYYRSTISKMNEKLKKQKEFLYAAKEEITQLSKYKLQVQELTNEIDLLRKQLQSTARPDTFDLSNDNENEKSGEFENNIFTRESSPTQTASHTFINKVHRESLQKVIPTSKPDTDDRNGSTRRRSFFAESTKLGEINSRSISSSNESSNSLNSLKRFSFESPKKKYLQNPIGKRSATSQLATRITANMKLGVPVSASNASSRSYQNGYVNKVSKDPTLTRTMRRASEASPYFKGLNYKYKNSSHDHHQHQYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHU1</accession>
    <name>A0A1D8PHU1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">TPK2</name>
        <name evidence="16" type="ordered locus">CAALFM_C207210CA</name>
        <name evidence="15" type="ordered locus">orf19.9817</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714866.2">
        <property type="nucleotide sequence ID" value="XM_709773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHU1"/>
    <dbReference type="SMR" id="A0A1D8PHU1"/>
    <dbReference type="FunCoup" id="A0A1D8PHU1">
        <property type="interactions" value="819"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHU1"/>
    <dbReference type="GeneID" id="3643482"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207210CA"/>
    <dbReference type="CGD" id="CAL0000181882">
        <property type="gene designation" value="TPK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07210C_A"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHU1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036164">
        <property type="term" value="P:cell-abiotic substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044114">
        <property type="term" value="P:development of symbiont in host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071969">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070314">
        <property type="term" value="P:G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010570">
        <property type="term" value="P:regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900428">
        <property type="term" value="P:regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900239">
        <property type="term" value="P:regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900231">
        <property type="term" value="P:regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044409">
        <property type="term" value="P:symbiont entry into host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="103"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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                <person name="Martchenko M."/>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
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    <reference evidence="7 8" key="2">
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                <person name="Martchenko M."/>
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        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <location>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000174018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="352" mass="41156" checksum="20DE59198DF93918" modified="2017-01-18" version="1">MSTSASSRKKLLLMGRSGSGKSSMRSIIFSNYSALDTRRLGATIDVELSHLRFLGNMTLNLWDCGGQTVFMDNYFTNQKDHIFKMVQVLIHVFDVESKSINKDIEIFIKSLTNLQQYSPGAKVFVLLHKMDLVQIDKRQELFEIMMEKLQKISNPYHFKLIGFPTSIWDESLYKAWSQIVCSLIPNINLFNNNLIEFNSILDAEEIILFEKTTFLVISSTASIQQQQQQQQQQQQQQQQQQQQQQQQQKSIDNDQDSTNEELDPKRFEKISNIIKTYKQSITKLRTNFKNLIIRGSNGTNFYIDIITDNMFIMIVLKDKKDTQNMIQQHEELLILDNIKAARRWFEKIENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C208540CA</name>
        <name evidence="4" type="ordered locus">orf19.11108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
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            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="190"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40837" checksum="D057923F9F504B1B" modified="2017-01-18" version="1">MEESNDYPSCSLQNSFISTLDHLPCDIVRSLWLIQSCNLKIDKYKQELNELLEKYATTTTTLTNEESYFLKRIVELKKRIEYLSRETIQESRSMNNQLITHKLNLLEEMNQLKKIEISKHNLIDDIEMKELRQQLKTHYNEHPLVSQMEAVQEQKDLIISSNDKSQTNDKNGGSSDSSSNTNGILKNKIKDEPEKSKLKLILRIPKQDKVIKPKNKKIVKKVQKKPTERNTVISKDNKKSKTLRKKVPQLIELKEEPEKEEEQEDTTLYCFCKQPSFGNMISCDNESSCPNGEWFHYKCVGILNRVVALKYTTGKESWYCSENCKSMALQAKQSKKQKNGKRRKRRSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="13">Smm1p</fullName>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
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    <comment type="catalytic activity">
        <reaction evidence="9">
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    <dbReference type="STRING" id="237561.A0A1D8PIL3"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C209890WA"/>
    <dbReference type="CGD" id="CAL0000181192">
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    <dbReference type="VEuPathDB" id="FungiDB:C2_09890W_A"/>
    <dbReference type="eggNOG" id="KOG2334">
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    <dbReference type="OMA" id="DESYTMT"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
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        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Weissman J.S."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_717998.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PK25"/>
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    <dbReference type="STRING" id="237561.A0A1D8PK25"/>
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        <location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="286" mass="32565" checksum="6D6F77A0BA9453A0" modified="2017-01-18" version="1">MSFANIDLEAQKEPLLKGKENDANYTSPDELDTIIGKTSRQLSVFGNLISQFETQRKQIGTRRDTQELRNTIDVLTGKIQEMDRAISALIANLSTLINSKNSITASASISNRHIVIEERLSRQYSELSKAFNKSTKVYQEKKRTTPLLTRPSKETEEQTKSEDTLATSQQEQEQVQTQVDQDLIDQTELQYHILLTEERNREIEQVTEGIMEVNSIFKDLSQLVHQQGEQVNTIEDNILQLHGNTQQASNELNKANEYQKQKGKWSCILLVALCIFLLVIVLIVVS</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="751" mass="84267" checksum="44943E199A1089EA" modified="2017-01-18" version="1">MTGGSWLSWNAKKNESINQLSESNEDVIDEDEEHPNDEESEHDDTVPDDNGDEVDDHVKEKRGSGWAFWGNSNTNVESTLQNVKDSKSSGASDQDNVESTSKKDKAVHVGNTILSSTSKFLVKSESTGKAPQNTEQGDDAVLYKPHDKTAQFNQINTHKNEDLRENLIVPDWNTCLPQTATNPIFNTSTTSNQGNANQTVRTDITNWRQFLGQISSKFGFSSNPTLPEEEEQSQSPGIESNIERDVGLLYEKSYKLYGKSLAVLPENKRACLPNYNKYYHNVDEKSIKSASSVPSQLQEDSSDPNSITITNDAMGNLLINNSISSKRRALHQALNAEVISQKAGPLKKIKDILIIGVHGFFPTRMIRPIIGAPKGTSLKFANEAEKAVIRYCVENNLINENESNVSIQKIALEKEGKVFDRVEFFTEILQKWEKELNNADFIFVAAHSQGCVVSIILLAQLIKMGILKNPLHKRIGILGMAGVNNGPFYGVDKSFFMKAYSAIENESLLELFELNKFDSQQSIAYKDSIQTIINANVKICFIASINDQLVPLFSALASHIFHPNIYRACYIDYTSHTPQFVGKLVSLCTHLLNIGYFDNNVIKELSTSLAGPFSGNGHSKIYNDGKVYDLGIKFVLDTDDIVIPFDGESNLSEEITKSELPISNQIYIKEYNIAKIGTNPYILPWCLRGLLFNIEKNWPNKRAGRIEDKETVKNGYEEIHDLYESFENWKPETKVYKDLKFRLNGLRASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKW7</accession>
    <name>A0A1D8PKW7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C307900CA</name>
        <name evidence="2" type="ordered locus">orf19.6186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710942.1">
        <property type="nucleotide sequence ID" value="XM_705850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKW7"/>
    <dbReference type="GeneID" id="3647450"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307900CA"/>
    <dbReference type="CGD" id="CAL0000183174">
        <property type="gene designation" value="orf19.6186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07900C_A"/>
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    <dbReference type="OMA" id="AWFLIDY"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
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    </dbReference>
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        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000183174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="354" mass="40340" checksum="E7B56B5E0A635B43" modified="2017-01-18" version="1">MFCGYGNPWEMIVDSKETTGRFSNSACLTSCDIRKSDRFIVDKEDHRKNNHQKNFFFTMTFLDTTPSYELVHYLSLHANPNLPGSTPENVQQIMSSFDYHPYIPQLIRDFKASSKKVKQKNLVEDLGVLSQAWFLIDYAYSQEICILSMLLVEDVLTTYSVSAKIQAFNLLSHLPELNQPLIPQLRSAASKCLVHVPPITPLDESLRLLAQAYEWVYKLNTTTTDFIETVATILSTINTPARPFLLQQLSKYTRHLSTDVFISTSKIFYALNQILVSLDATRNEIVTALTIQHDIINLNHPFIATYAYDFIGAWSILSKHHPGKFSAQLQLNISSLQKLANNDDIDKLCTYINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKY2</accession>
    <name>A0A1D8PKY2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">FRP1</name>
        <name evidence="18" type="ordered locus">CAALFM_C400110CA</name>
        <name evidence="17" type="ordered locus">orf19.13079</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713315.2">
        <property type="nucleotide sequence ID" value="XM_708222.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKY2"/>
    <dbReference type="SMR" id="A0A1D8PKY2"/>
    <dbReference type="STRING" id="237561.A0A1D8PKY2"/>
    <dbReference type="GeneID" id="3645005"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400110CA"/>
    <dbReference type="CGD" id="CAL0000187683">
        <property type="gene designation" value="FRP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00110C_A"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKY2"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140420">
        <property type="term" value="P:heme import into cell"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="270"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000187683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="554" mass="64733" checksum="FC4C0A58B3D7E507" modified="2017-01-18" version="1">MAIPFDQQFFVEKDRNNKYEWLIFVLTFIVLAGHGILFYWIPRYLRVNNKRNNYFRLLKVWDAWTSCVHVWGDFYFQPSLVLLGILFVGLNVGFCFAEINDLDYQSRFYIISKRLSKVAVGNLPILLFAVMKNDLLTSITGLQHDRLEFVHKWLSRLMWVMITIHMGMACYYWLNLNFKIMIMIPPQIFGFMAYGSFSILNWASLKFIRQFAYDFFLVQHRIFAFMMLFFTFIHNQGNRAVVLISVHGLVIDRVVSKVFAYLHAKKSPTKGRCTFRIIDDSTISVVIPVSEAGYTSKSWYTRFLPKYKTWKAGQHIYLNVGKIKFFQYHPFTISSLAESGEMKLLIRVERGFTRKLMRHLEQVDHDEVTIKAMFHGPYGARYQPLITFDTCLFFAAGSGGAFTFPVCLDLLNQIDRRDQEGDVLFRPKNQFIKFVWAIRKQDNIEWFEDSLKQFAGRCSVDIYITQETKEELPLQRKNSIIEITKSLTNDYNILYGRPQIQDIIQQHSQSLGANQSMAVTSCGSPSFTNSIKHHCQSARRVKGAPEVYCYTESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL02</accession>
    <name>A0A1D8PL02_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C400330CA</name>
        <name evidence="13" type="ordered locus">orf19.5660.1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330901.1">
        <property type="nucleotide sequence ID" value="XM_019475356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL02"/>
    <dbReference type="SMR" id="A0A1D8PL02"/>
    <dbReference type="FunCoup" id="A0A1D8PL02">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL02"/>
    <dbReference type="GeneID" id="30515227"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400330CA"/>
    <dbReference type="CGD" id="CAL0000181686">
        <property type="gene designation" value="orf19.5660.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00330C_A"/>
    <dbReference type="eggNOG" id="ENOG502SDS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL02"/>
    <dbReference type="OMA" id="WARDHPS"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000181686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="93" mass="10388" checksum="300D505D5F5BCA32" modified="2017-01-18" version="1">MSTFNVLRYSLLGAGIVYGAYTRFSVDSAFKAEQAAKKWRQEEKLIQQAKAEYARLHAPKKDTSSASTSGSINWEDPNLDFGKALESLIQKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL14</accession>
    <name>A0A1D8PL14_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">CAR2</name>
        <name evidence="11" type="ordered locus">CAALFM_C400160CA</name>
        <name evidence="10" type="ordered locus">orf19.13086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713322.2">
        <property type="nucleotide sequence ID" value="XM_708229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL14"/>
    <dbReference type="SMR" id="A0A1D8PL14"/>
    <dbReference type="FunCoup" id="A0A1D8PL14">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL14"/>
    <dbReference type="GeneID" id="3645027"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400160CA"/>
    <dbReference type="CGD" id="CAL0000189642">
        <property type="gene designation" value="CAR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00160C_A"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL14"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006591">
        <property type="term" value="P:ornithine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000189642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="436" mass="47349" checksum="0B7428E73BA5D088" modified="2017-01-18" version="1">MSSTPDFKVSSETAREYETKYSAHNYHPLPVVFSKAEGAHVWDPEGKEYLDFLSAYSAVNQGHCHPKIVAALVDQASKLTLCSRAFSSDVFGVYAKYITEYFNYEMVLPMNTGAEAVETGLKLARKWGYDKKGIPSGEAIILSAVNNFHGRTLGVISMSTDPDATTNFGPYLRGVGPQIPGEPEGTLLRYGVIEDVEKAFANAGDKIAAILLEPIQGEAGIVVPPEDYLPRVQELCKKHNVLLICDEIQTGIARTGKMLCYEHSKGVKPDIVLLGKAISGGVMPVSAVLSSKQVMLTLEPGSHGSTYGGNPLACRVAIAALDVVRDENLVERAQKLGALLREKLEELQKESNGMISEVRGKGLLSAIVIDESKTNGRTAWDLCLLMKNHGVLAKPTHDNIIRLAPPLVISEEDLLKGVDSIRKSLKELPNVAKTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL41</accession>
    <name>A0A1D8PL41_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C400500WA</name>
        <name evidence="8" type="ordered locus">orf19.4191.1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    <reference evidence="6 7" key="1">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
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    <dbReference type="GeneID" id="3635683"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401120CA"/>
    <dbReference type="CGD" id="CAL0000185903">
        <property type="gene designation" value="orf19.12147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01120C_A"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLB8"/>
    <dbReference type="OMA" id="YEHRAYF"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF3">
        <property type="entry name" value="LIPASE LIH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012068431" description="triacylglycerol lipase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="103"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000185903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="333" mass="38265" checksum="2F3B891D13427B5B" modified="2017-01-18" version="1">MLILIIIVLYCLSFAQEYKTDNEPAQDYKKIVQFSNLAAVAYCVGRGLSKGRLGDKGSGCHLSACKNDILKDVEIVKIFDFSTLNEVGTGYYALDKKRKTIILVFRGSVSRRDWATDIDFIPTKYRPIVQDDNFECEVFIQQECINCKVHRGFYNFLKDNSGAIISLGIKFKKIYPDYQFLIIGHSLGAAFTTLSGIEFQLLGYDPLVVTYGGPKVGNQEFADFTDRLFDTEEVANCITMKNDFSRGFIRVVHKHDIIPFLPPMFTHAGYEYFIDKKQLPHEECDIDRRGMEYSGLLWKRSSGIRPSTFWPDSLGKYEHTHYFRRITSCRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM73</accession>
    <name>A0A1D8PM73_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Csr1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">CSR1</name>
        <name evidence="11" type="ordered locus">CAALFM_C404850CA</name>
        <name evidence="10" type="ordered locus">orf19.11274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717199.2">
        <property type="nucleotide sequence ID" value="XM_712106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM73"/>
    <dbReference type="SMR" id="A0A1D8PM73"/>
    <dbReference type="STRING" id="237561.A0A1D8PM73"/>
    <dbReference type="GeneID" id="3641162"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404850CA"/>
    <dbReference type="CGD" id="CAL0000185267">
        <property type="gene designation" value="CSR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04850C_A"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM73"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900231">
        <property type="term" value="P:regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000661">
        <property type="entry name" value="paternally-expressed gene 3 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000185267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="618" mass="70659" checksum="057CD1B1864EBF05" modified="2017-01-18" version="1">MEPISNQPNFNFSCPALDDLDFCKDVFCNDLDDCFYLNCDDNENSNTCDVNCCDSQVDEICCTNDKCLEPKSEQPPSCEKSEHLECCDDPHCESYNVCHSDLGDSSSVVCTDPNCSEIDTCCSSLPQPTLPSHSENNLCQPQLSKRPIFEDLITNVHLSCKQTQAEEINSVYPPKKKIKRESDFDIHFPHECHQDYKNPFTATATTNHQLHQSCFHTTIPDRKNTSLEYDEKLMSDFDFVIQFNNFNQLLNTATKHEQQGQHEQQKQQNQFVKETTDFNQVSTNRPTSYSCQWENCFKRLNNNTFLNHVIEDHLEKEEIVKSENSNYQCEWNECNFTDNDFNSLINHLKSHQPSNSVETTGCSSLLNNVTNNYALTPLSCTLSNDASPVVALQSPQAPDLNITSVKIVPKNKRKSCKPKVKKEDQEMDLEHTCNWQIGTDDNGDPIYCNIKHQSPGDLHSHLLDVHIGSGKHEYHCCWRGCERHNGKVFTQKQKLIRHIHIHTNFKPCKCDICGASFAVESVLQQHYRVHSGEKPFKCPICDKTFATSSSLSIHTRVHTGERPLVCKWPGCNKRFSESSNLAKHMRIHTKKFNCEACGQSFDKKGVFNRHVLEHSVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN55</accession>
    <name>A0A1D8PN55_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C501350WA</name>
        <name evidence="8" type="ordered locus">orf19.9489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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                <person name="Federspiel N.A."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </comment>
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        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
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    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="352" mass="40184" checksum="CC3EF210AB49A8DE" modified="2017-01-18" version="1">MYGQIVIGPPGSGKSTYCHGMYQFMSAIGRKSCIINLDPANDRLPYPCELDIRDYISLEEIMEELDLGPNGGLMYALESLDKQGIDLFIGKIEQLINEGNYLLFDCPGQVELFTHHNSLYRIFKKLTQLKRLRLCVVSLIDCIYLTSPSQYISILLLSLRSMLQLDLPHVNVISKIDMLKNYGELPFRLDYYTEAQDLQYLTPYLEKESNSVLGQNYVRLTELIGEMVEDFHLVSFEVLSVENKKSMISLMSVIDKANGYSFGSEIGGDTVWSEATRQNGSGNGGYQDVDIHERWIDHKEEYDAEERKQEQAFAEGLPQEEVDNKPLTEDEEWEAALKDWEEKHGGEGAMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Rho family guanine nucleotide exchange factor</fullName>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <begin position="288"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
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        </location>
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        <location>
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            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000179183"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="530" mass="59681" checksum="650904058B002342" modified="2017-01-18" version="1">MGLKNHMNSDSSRNSNSNVNVLKKKRNLKKVKMVVSKVDMQEEMVKMEMRAIAKAKVGSFNLVSQGSDKQQDELTIAKLKENKVVKENELFGMNDEIEELEKRAGKFWKWKGGSKNKEYSGFKEEDYIEEDKVSKKKVIKDKLIGKFKKQGDNEFGLSADDDPDDRDLVDELLLRVFNSLKGSGFINDIIRMSLTDPRVRSGMIDMTIRLLNAEVIPWDDIFIALKRHGLAIDVIKFTFTDAQTRVGLAAFVIELLPALVTSGALDLRQILETVPRLQEESIKMYNGGNRTHNSTDPADSGNRNHGFEDSVGSIIDSENQAESGINEHVIPKKNSSSINPISKETPTPDVPKVTIPSEKNSSDNYNDQVKNDGKESKSSLNDKEKEKPMNLPDVPLIDNPKNWDDKTLEEKVEEYKKLKEQYDEARRKLVTNENSDLIRDHTYFNNPEKLKNIKPLFPKTGVKYTNNTSNGTVGNHAAPYPRVRIFYDGTFVPNYPVDFKPPIAGGPSTNFEPNSNSIKPNAEPTVGVAT</sequence>
</entry>
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            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31127" checksum="EB26E9B04C88A974" modified="2017-01-18" version="1">MGYPSPLKVVTKKISPNVLTVSSPFSILNKLNVGARMVIFHYHGDIIIWSPLPYDKEILENAIAELTTEEYTVKYIFVINIEHNLCAEKYKQIYPNVKLIGPENTARCEINIPLTEDNALKIIKGNEGWGDLGISDKSIIDNFELIYNNAHKNRELVIYEKNDKLLLLADMIMNLGIHGTTTGEHVLEQYSPELGFPKGFNPHGGWSFLSRYLQPNSVVGKFLMNRLQKTRQTPEKTKKVMELINSWDYTTIIMVHGDLITKEAKRTLSDVHL</sequence>
</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ER membrane protein complex (EMC).</text>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP73</accession>
    <name>A0A1D8PP73_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C505350WA</name>
        <name evidence="11" type="ordered locus">orf19.11513</name>
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    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Pichiomycetes</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721938.2">
        <property type="nucleotide sequence ID" value="XM_716845.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP73"/>
    <dbReference type="SMR" id="A0A1D8PP73"/>
    <dbReference type="FunCoup" id="A0A1D8PP73">
        <property type="interactions" value="1346"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP73"/>
    <dbReference type="GeneID" id="3636401"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505350WA"/>
    <dbReference type="CGD" id="CAL0000183321">
        <property type="gene designation" value="orf19.11513"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05350W_A"/>
    <dbReference type="eggNOG" id="KOG2851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP73"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000183321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW29939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="424" mass="49666" checksum="1B02041BFA8489CE" modified="2017-01-18" version="1">MKFYYQRLLPFRYIFQWLSHSPKPTKDFTMREFAYEYRSKIYQRYNSFGTLEEFKKSVVTANPTRFEIGAVYKINPKERKNLPKQAFKPESKELVFDIDLTDYDDIRTCCQGTDICCKCWKFIQVGSKIIEAALREDFGFEHLVWVFSGRRGAHCWVSDKRARELDETSRKAIIDYLDVLSSKNQNGSLNIKKPFHPHVERSFEIVKKEFLNVILQEQDPWNTTSEETKAWKQVDELLAFIPNKALQIELKNKWKGQTFGSTSKEKWDDISTVASNVLKSNSQVAQLTEAKKDIIIYYMYPRLDVQVSRQVIHLLKSPFCIHPGTGNVCVPFDPLKNISGNPADDDYGFNPKSAPNLRKIQNELEEWEQNRSDENDSQEKVIADYEKTSLKPYIDYFAKFVNNLLKEELKGTEKRSREEDPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP74</accession>
    <name>A0A1D8PP74_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger CCHC domain-containing protein 17</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Nucleolar protein of 40 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Putative S1 RNA-binding domain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">PRP22</name>
        <name evidence="26" type="ordered locus">CAALFM_C505370CA</name>
        <name evidence="25" type="ordered locus">orf19.11516</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with PNN. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721941.2">
        <property type="nucleotide sequence ID" value="XM_716848.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP74"/>
    <dbReference type="SMR" id="A0A1D8PP74"/>
    <dbReference type="FunCoup" id="A0A1D8PP74">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PP74"/>
    <dbReference type="GeneID" id="3636404"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505370CA"/>
    <dbReference type="CGD" id="CAL0000197565">
        <property type="gene designation" value="PRP22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05370C_A"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP74"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000154">
        <property type="entry name" value="nucleolar protein of 40 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="76"/>
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            <end position="513"/>
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        <location>
            <begin position="535"/>
            <end position="711"/>
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        </location>
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        <location>
            <begin position="191"/>
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        </location>
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            <begin position="237"/>
            <end position="303"/>
        </location>
    </feature>
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            <begin position="152"/>
            <end position="168"/>
        </location>
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            <begin position="195"/>
            <end position="207"/>
        </location>
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            <begin position="208"/>
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        </location>
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        </location>
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            <begin position="260"/>
            <end position="282"/>
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        </location>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="996" mass="113406" checksum="0CBA09AD79A2949A" modified="2017-01-18" version="1">MAQPTTQLLSIVQKHLDLPQDDENVVLIAKFLVNLHGNSTLEEFKKVVKENGGDEFEDEFIKEVYNEISPPPPQVGKIYSGVVQSVTNYGAFIKIEGTSGLCHISQMSFDGSRVESTNVLAPNQKVFVKVIDIQTHANRISLSMRGINQNTGHEEPIPQRGRHQERQPRPKRKLTSPERWEIRQLISSGAVSADDYPELDQEEDTQTESEKTDNLHIELNDKKPDFLKGVKVTKDFPDTTPIPVNQSGPLTKSAQRGSKFARDFKEEKFKQKKQREKEEKIQSELSDPLFQTSEPVKNSDLDPDTESFISKWKKSNKTETFGKRTSLPIQEQRRMLPVYAMRSQLLEAIRDNQFVVIVGETGSGKTTQIVQYIYEEGMNKVGGQTKLIGCTQPRRVAAESVAKRVSEEVGCKLGDTVGYTIRFEDVTSENTVIKYMTDGMLEREALNDPNMNRYSVIMLDEAHERTIATDVLFALLKNAAKQNPNLKVIVTSATLDSNKFSRYFNNCPIITIPGRTFPVEVLYTKAPEMDYLAAALESVIQIHVSEPAGDILVFLTGQEEIETSCEALHERMKLLGENIPELIILPVYSALPSEMQTRIFEPTPPGSRKVILATNIAETSITIDGIYYVVDPGFVKINMYDSKLGMDSLRVTPISKAQANQRSGRAGRTGPGKCYRLYTEQAYEKEMIPNTIPEIQRQNLSHTILMLKAMGIHDLVNFEFMDPPSTTTMLTALEDLYILDALDDDGNLTTLGRKMADLPMEPALAKTLIQSVEYECTEEILSIVAMLSVQTIFYRPKDKQALADQRKSRFHHSLGDHLTLLNVFQSWCRNNYSKTWCRDNFIQERSMRRAMEVRKQLKSIMQRFGYKTMSCGNDVDRVRRTFCSGYFKNSAKRQEGEGYKTLNENTLVYLHPSSSLYGKKPQYVIYHTLLLTSKEYMHCVSIIDPNWLYELAPKYFRPADAKTVQEIKKKQKIVPLFSRQKKDNWRLSSHRPAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPJ4</accession>
    <name>A0A1D8PPJ4_CANAL</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C601200WA</name>
        <name evidence="3" type="ordered locus">orf19.7777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000179004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="224" mass="26026" checksum="3DFDE3537F4692D7" modified="2017-01-18" version="1">MINEDEEEFVYAQKQALPISSESEDPISQYLLAVRKESLAGPPVTFITNRQAPQITSTPKSTPQNNRDQISDHWSSELMTQFVFLKEELLKTQHSIPINPHIPETTANWRKYFLEPPPEISYFFTVIDRQTVFKLLVYITRWLSITSRPTLSQWIWKLFLRIDKVLDPNECSVIRDLGKKALTIKSKQLKDENKATVDSISKYTTDMILVIVGNYYGQSDLLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPS2</accession>
    <name>A0A1D8PPS2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">PLB2</name>
        <name evidence="13" type="ordered locus">CAALFM_C602000WA</name>
        <name evidence="12" type="ordered locus">orf19.8309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Dungan J."/>
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    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    <sequence length="396" mass="44455" checksum="16543DA9E76F9A07" modified="2017-01-18" version="1">MQPVTSEESSGVSTRESFEIEDDSLQSDSNLNPLGVSLYGSKTIESIVYILGWYFFSLSISIYNKWMFGSGLDFKFPIIITSFHQLCLCILSCVVLYLKPNLRPLHTTNVSTPTSTNGISGQTIGKFLQSLLMDFPIYIRQIFPCSIASAGDIGLSNVSISLITLSLYTMLKTSSLMFVLLFGLLFKLEKFNWRLIFIVAIMTISVIMMTDKPESGSSSSSSSSVGIFMVLMASMLSGLRWSFTQILLKKNPYTPNSISTIFYISPGMCIILFSLGLIFEGWTNFINLEIWITKGLFTTIILLIIPGVLAFMMTLCEFKLLTVAQVITLSVAGIFKELLTIILSSIIFGDKLSLINILGLILTFMDILWYNYYRYYENEDHNNGNSKSVLREDLER</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRF5</accession>
    <name>A0A1D8PRF5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sla2p</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="10" type="ordered locus">CAALFM_C703810WA</name>
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    </gene>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715249.1">
        <property type="nucleotide sequence ID" value="XM_710156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRF5"/>
    <dbReference type="SMR" id="A0A1D8PRF5"/>
    <dbReference type="FunCoup" id="A0A1D8PRF5">
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    <dbReference type="GeneID" id="3643149"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703810WA"/>
    <dbReference type="CGD" id="CAL0000178056">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03810W_A"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRF5"/>
    <dbReference type="OMA" id="FQMSVEM"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRG0</accession>
    <name>A0A1D8PRG0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">54S ribosomal protein L2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">MRP7</name>
        <name evidence="12" type="ordered locus">CAALFM_C703790WA</name>
        <name evidence="11" type="ordered locus">orf19.7203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715251.1">
        <property type="nucleotide sequence ID" value="XM_710158.1"/>
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        <property type="interactions" value="298"/>
    </dbReference>
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    <dbReference type="GeneID" id="3643118"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703790WA"/>
    <dbReference type="CGD" id="CAL0000182661">
        <property type="gene designation" value="MRP7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03790W_A"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRG0"/>
    <dbReference type="OMA" id="YLDPFHP"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL27"/>
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        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL27m_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18471">
        <property type="entry name" value="Ribosomal_L27_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL27m C-terminal" evidence="10">
        <location>
            <begin position="139"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000182661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="389" mass="44568" checksum="9754D7EC178DD9CA" modified="2017-01-18" version="1">MSSFVKGLFSHTRKSIDLTSNPLHTSIQIRTAKKRVSGSRTNNKDSAGRRLGPKKNEGHFVNPGQIIMRQRGTKIHPGDNVKIGVDHTIFAVEPGYVRYYFDPFHPLRKYVGVSLKKNLKLPRPHFEPRLRRFGYVQITDPIEAQEEEASQSRKEMLAQPELEKLKEKKLNEKIQFIESTKTALVNEFGFDSEPSSKQLEDASERLYNIYQLRASGQSLSEARIQTTFNTLYDLKLQAQKNNIDSLPNLLNEAKEFITRIDSIVGIEPTGELFKNLTKEEQLNLQKEISSELDTLYQTKALEKDYRIEAKKLINTPGVFEPLQREELMAKYLPQVLPMDYPGSVIEISDSDSKNKNKKLSENIVIQRIFDETTRKVKLIGRPKEAFASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRM2</accession>
    <name>A0A1D8PRM2_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR00040CA</name>
        <name evidence="2" type="ordered locus">orf19.7539.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718696.1">
        <property type="nucleotide sequence ID" value="XM_713603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRM2"/>
    <dbReference type="STRING" id="237561.A0A1D8PRM2"/>
    <dbReference type="GeneID" id="3639675"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00040CA"/>
    <dbReference type="CGD" id="CAL0000177121">
        <property type="gene designation" value="orf19.7539.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00040C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PRM2"/>
    <dbReference type="OrthoDB" id="4028283at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021642">
        <property type="entry name" value="DUF3246"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11596">
        <property type="entry name" value="DUF3246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000177121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="389" mass="40055" checksum="46A8A90E0C05A04C" modified="2017-01-18" version="1">MEAPNFGPTIPTLPITSQSKTSVSSVVSKSTTEDNETDCETDVPTIIPSGSVLPTTSVLPTIIPTGSGSITVLPTKSTTSDDDDDETDCETEIPTIHPTVSTTRTFTSDGVPTTQTLTTKLPPTTNQHTETEVVSITYTGGGQTFTTYLTQSGEICDETVTLTITTTCPSTTVAPGGQLYTTTVTVITTHTVYPDDWEDDGYEGEDNAGGSASGSSDDGEWEWYEEDDGECVPTGGSSSGSGTGSWWGSGAGSSGGTTSGSSSGVSSGDSGSSSVTGGSSGSWWGGSGNDYVCPGEDGYDDEDDQTPEPECDDEDDSWDDDEECDTQAAKEVVNSVTVAAESVYPSTTAASLTTSWISTQTAQSVTQIENIGGKVSASGLFVVLGLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS88</accession>
    <name>A0A1D8PS88_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exosome non-catalytic core subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR02550CA</name>
        <name evidence="10" type="ordered locus">orf19.7801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710705.2">
        <property type="nucleotide sequence ID" value="XM_705613.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS88"/>
    <dbReference type="SMR" id="A0A1D8PS88"/>
    <dbReference type="FunCoup" id="A0A1D8PS88">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS88"/>
    <dbReference type="GeneID" id="3647689"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02550CA"/>
    <dbReference type="CGD" id="CAL0000191642">
        <property type="gene designation" value="orf19.7801"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02550C_A"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS88"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="42"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000191642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="291" mass="31792" checksum="BEE82F4602382C19" modified="2017-01-18" version="1">MSDRRRLLGPSGMIIPNIPKQQQKSIITTTTTTSTSTIPSFFLKHSIIDNANGSAYLEINNTIIEVSIFGPRPIRGSFIDRASVSVDCKFLPHIIQPMGSIFNDTTTSGGGGGISSSNRGYRTGMNNIEHKLSSYLETCVLSSLILEKYPKSTIDIQVSIISIDKEIGGGHSLLWLLQWITCCCSLALVDSGIEMKDIISSGQVRLTKSGKIIIGGNSDKTSTEDGIDGLVSFMNLKNDEIVGIWFEGEGDDNNNEDSLLNESNMEKLIIECNKMSKIIRANLNSYLINSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSI3</accession>
    <name>A0A1D8PSI3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_CR03520CA</name>
        <name evidence="4" type="ordered locus">orf19.11873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW31090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715171.2">
        <property type="nucleotide sequence ID" value="XM_710078.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PSI3"/>
    <dbReference type="FunCoup" id="A0A1D8PSI3">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSI3"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of cytokinesis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000188252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="613" mass="67330" checksum="8AEBF76872455E97" modified="2017-01-18" version="1">MSIKPLSITVPHPSTQRGHATHISYDPVNERLAYVNGKSVIIRPVDFKSTSPTVVFSKHIFPTTAVKFSPSGYYVASGDEAGNIKIWDASPKSEPDFEQPVIKSEFQVMSGPIRSIAWDADNSRIIAVGQGKEKFGHAFSWDSGNSIGDIQGHSSPINVVDIKPQRPYRAATVGDDHALVFFTGPPFKFDKSLRGNHNNVVRDVKFSPDGEYIVSVGSDRVIAIYQGKTGEFVKKIEKAHEGGIFAVAWLPDSKHFITASADNTLKKWTLDGENTQKFEISSTTSVGNQQVGLALTKEFVVSLSGNGNLNYFDHEGNLVQIVQGHQSPITKVEFHDGFLLSGGSDGKLFKWEVGTDGPKALPVLQDDDEHSNYVVDILTVDDVTYTTGWDDTLKSWRDGKVVSSVKLPSQPKQLGSIKGAVFVLFESALQLYTEVNFQLIAETKFDFTATYAAPTNDTHILITNTTSNTVEEFQVGNGEIRKTSKEFPKSRSPPTFITVSPSREFFAVADSAGKYTLFNTSDGTVVSTRWAFHNSKVFDAKWTSDSKYLISGGLDSSLLLYSVEKPSRVVKYLLAHPSGISSIDWVAYDSEKKTGTFVSAGLDATIRSWYISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSK4</accession>
    <name>A0A1D8PSK4_CANAL</name>
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        <submittedName>
            <fullName evidence="7">SUMO protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">ULP2</name>
        <name evidence="7" type="ordered locus">CAALFM_CR03820CA</name>
        <name evidence="6" type="ordered locus">orf19.11831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715130.1">
        <property type="nucleotide sequence ID" value="XM_710037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSK4"/>
    <dbReference type="SMR" id="A0A1D8PSK4"/>
    <dbReference type="STRING" id="237561.A0A1D8PSK4"/>
    <dbReference type="GeneID" id="3643196"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03820CA"/>
    <dbReference type="CGD" id="CAL0000188490">
        <property type="gene designation" value="ULP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03820C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PSK4"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.130:FF:000008">
        <property type="entry name" value="Ubiquitin-like-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="299"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000188490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW31120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="491" mass="57094" checksum="10D7213BFA24A21D" modified="2017-01-18" version="1">MIQSTNNPLISTQRIEINDEYEPENNSECSHKPTDSNIFRLFYNILKYLKVYILSTLFRRIEPSNRHLQSEENKEEDDEYINLSSEASSDIEIIAVNYKPTNDFHLINKTTRIQDNSILIDDTEETPFNIANNDSTTDLLRQLAKDRLKNRKTVTTQYGTDLTISKPIKYSSSRYQQWPVTQAETTTSTPEENFDHQPTLLDIEPITNKYQESILNYYVPTKPLSINSYSVIDNVISNFYIDKISSIYHKSHETLQQLITKERIDSQSKIKTLPSEQLNQVLKIWSTNSRQLIIENYSIEIYTHDLHTLKDSNWLNDNIIDYYFNLIMKANPNVFGWTTHFYTTLVQRGYQGVARWAKRKKINVFTMEKILTPINIGNMHWALAVIDNIKKTITYYDSLGGTHNSGNPQAVQTLAHYMTEEAKRLGVMGNEYKLIPHMEAPQQKNGSDCGVFTCTAARYISANKPLSYSQNDMKIIRRRMVYEILDNRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSQ3</accession>
    <name>A0A1D8PSQ3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type I HSP40 co-chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">YDJ1</name>
        <name evidence="11" type="ordered locus">CAALFM_CR04200WA</name>
        <name evidence="10" type="ordered locus">orf19.8136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717369.2">
        <property type="nucleotide sequence ID" value="XM_712276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSQ3"/>
    <dbReference type="SMR" id="A0A1D8PSQ3"/>
    <dbReference type="FunCoup" id="A0A1D8PSQ3">
        <property type="interactions" value="1288"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSQ3"/>
    <dbReference type="GeneID" id="3640939"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04200WA"/>
    <dbReference type="CGD" id="CAL0000196010">
        <property type="gene designation" value="YDJ1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04200W_A"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSQ3"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="term" value="F:ATPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cellular response to heat"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140454">
        <property type="term" value="P:protein aggregate center assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:protein targeting to ER"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to mitochondrion"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:tRNA import into nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Type I HSP40 co-chaperone"/>
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        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
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    <dbReference type="HAMAP" id="MF_01152">
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        <property type="entry name" value="DnaJ_C"/>
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    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="DnaJ_domain_CS"/>
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    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
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    <dbReference type="InterPro" id="IPR008971">
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        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
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    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
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        <property type="entry name" value="J_dom_sf"/>
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    <dbReference type="Pfam" id="PF00226">
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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            <begin position="6"/>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31158.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <sequence length="393" mass="42732" checksum="44AD7AC5B72E7ED4" modified="2017-01-18" version="1">MVKDTKFYDALGVSPNASDAELKKAYRKAALKYHPDKNPSPEAAEKFKELSHAYEILSDDQKREIYDQYGEEGLSGQGAGGFGMNADDIFAQFFGGGFHGGPQRPSRGKDIKHSIACSLEELYKGKTVKLALNKTVLCGECKGRGGAEGKVAQCPDCHGNGMKFVTKQMGPMIQRFQTVCDKCQGTGDLIDPKDRCKKCNGKKTESERKILEVHVKPGMKDGDHITFAGEGDQTPGVTPGDVVFIISQKPHPVFQRKGNDLLIEQEIELATALAGGEIAFKHISGDWVRIEIPAGEVIAPGSIKMVEGFGMPVRTHKGNLIIHFNVKFPENNFADEESLKKLASLLPKPKEVKIPADADVDDCTMVPAKLEQSNPYESDEEAHGGPGVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PST1</accession>
    <name>A0A1D8PST1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR04680CA</name>
        <name evidence="2" type="ordered locus">orf19.9304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710256.1">
        <property type="nucleotide sequence ID" value="XM_705164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PST1"/>
    <dbReference type="GeneID" id="3648142"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04680CA"/>
    <dbReference type="CGD" id="CAL0000178105">
        <property type="gene designation" value="orf19.9304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04680C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PST1"/>
    <dbReference type="OMA" id="RIFIIPD"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000178105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="100" mass="11693" checksum="F38ADDEDD587B3AF" modified="2017-01-18" version="1">MLLALDIYKLFYWPGTEIDIVSGLAACHDNLTMGVFPRPVTTNQKNKANKEEEDEDEKIIEQTNEQQKKWEKNLCILSSTRSRIFIIPDFFLFQSVVFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT62</accession>
    <name>A0A1D8PT62_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR06140WA</name>
        <name evidence="2" type="ordered locus">orf19.11350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713494.1">
        <property type="nucleotide sequence ID" value="XM_708401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT62"/>
    <dbReference type="STRING" id="237561.A0A1D8PT62"/>
    <dbReference type="GeneID" id="3644862"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06140WA"/>
    <dbReference type="CGD" id="CAL0000181819">
        <property type="gene designation" value="orf19.11350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06140W_A"/>
    <dbReference type="eggNOG" id="ENOG502SSVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PT62"/>
    <dbReference type="OrthoDB" id="3980854at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000181819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="584" mass="66156" checksum="34AF14685F886F4A" modified="2017-01-18" version="1">MTGLSNLLNSEDLSNAPLKTIEQSSDQDSTKGTITPTRTLSSQSSPQLPLMSESEKSISSKTSYRPLVRLRDRLPKSKVNKKILASKRFVKLAIRRKYSTKKTKTDTKQSKLHIKSLKAGIKVKMTLSKNLFSLYHCLIPFTDDRTMYTLFNDDSSRTQMANLNSSVSEKTLISRGLQLINNNVVDLNDYSNKLIRSFTNKANNTTPTFNSLDTALNTLFETKNFTLVRITRSTTDDVHGSSILKLETATPGDFNLIDDEENGDEMLHSLGKEGEVPNNLFFKKIIARPRYKSNMKIYFIPEVANYSLYTDERMLERDLYNGIIQLEFENNDLNDLNVKRSNGYSRNVFCSFCYDQVLRDYKRSLFESDVAEVSPSNVQFIAPLANPPSQLQPGAVSVPPALPAANALFPTAPKLQQSPFTQRAQSIDDTMMVSYNDQQYPPYRPSIPLNRRPSLPMPKPPPAFIQQPQSFNVVTSNSMPSMMPYPATVPNTLPLVNFNQLVPPHQHQFHPEPQPLQQPHFANHHQHQYPTLPPHLQQHPVVLPQTPRSSSVQDGVIGLLRPVNERKFPPYPDMVDTRYMSIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTD1</accession>
    <name>A0A1D8PTD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30 31" type="primary">URA2</name>
        <name evidence="31" type="ordered locus">CAALFM_CR07050CA</name>
        <name evidence="30" type="ordered locus">orf19.9896</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="31 32" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="32">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="31 32" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712650.2">
        <property type="nucleotide sequence ID" value="XM_707557.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTD1"/>
    <dbReference type="SMR" id="A0A1D8PTD1"/>
    <dbReference type="FunCoup" id="A0A1D8PTD1">
        <property type="interactions" value="1786"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PTD1"/>
    <dbReference type="GeneID" id="3645728"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07050CA"/>
    <dbReference type="CGD" id="CAL0000196578">
        <property type="gene designation" value="URA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07050C_A"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTD1"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:glutaminase activity"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
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        <source>
            <dbReference type="PROSITE" id="PS51855"/>
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        <source>
            <dbReference type="CGD" id="CAL0000196578"/>
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    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="AOW31400.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2216" mass="244647" checksum="39DFD881209CE4CD" modified="2017-01-18" version="1">MAQLSVPITPPMESTGDVLMTLETQDGIALQGYSFGAAKPAAGEVVFQTGMVGYPESITDPSYEGQILVITYPLVGNYGVPDRELLDEDYEPALPKYFESNKIHIAGLVVAHYTEEYSHWLAKSSLGKWLQEQGIPAIYGVDTRSLTKRLREKGSTLGRLAIQNSDYKSEEIISQSKSNPQNWKKFFNVPEFDDPNVKNLVAKVSTDKPILYTPKKTNENIKLGKNGKPIRILAVDVGMKYNQIRCFVRRGVELLVVPWDYDFTTEEYDGLFISNGPGDPAVMDKTVERLQKILKEGKTPVFGICLGHQLLARATGASTLKLKFGNRGHNIPCTSTISGRCYITSQNHGYAVDTATLSNGWKELFVNANDGSNEGIYHESKPFFSVQFHPESTPGPRDTEFLFDVFIKSVVDFNQSGGVYKQVEFPGGKLAENRAAHPKVDVKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTVLINPNIATIQTSKGLADKVYFLPVTPEFVRKVIKHERPDGIYCTFGGQTALSVGIALKDEFEGLGVKVLGTQIDTVITTEDRELFASAMAEINEKCARSEACNTVKEAVDAANAIGYPLIVRAAYALGGLGSGFADNEEELVALCNKAFATSPQVLVERSMKGWKEVEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSKEYCIIEVNARLSRSSALASKATGYPLAYTAAKLGLNIPLNEIKNSVTKSTSACFEPSLDYCVVKIPRWDLKKFTRVSALLSSSMKSVGEVMAIGRTFEEAIQKAIRSTDYHNLGFNKTAALMSIDIDQELQTPSDQRLFAIANALSDGYSVDKVWKLTNIDKWFLNKLDGLIKFGNKIASYGAKEDVPMSILRQAKQLGFEDRQIAKFLGSNEVAIRRLRKDAGIIPFVKQIDTVAAEFPAFTNYLYVTYNADSSDVKFDDNGVIVLGSGVYRIGSSVEFDWCAVRAIRTLRENNVKTVMINYNPETVSTDYDEADRLYFEPINLERVLDIYDLEQSSGVIISMGGQTSNNIALPLYRQNVKILGTSPEMIDSAENRYKFSRMLDRIGVDQPAWKELTSVDEAEDFAEKVGYPVLVRPSYVLSGAAMNTVYSKDDLASYLGQAVDVSPDYPVVITKYIENAKEIEMDAVAKDGKMIMHVVSEHVENAGVHSGDATLIVPPQDLDPETVRRIVEATAKIGKALDITGPYNIQFIAKDNDIKVIECNVRASRSFPFVSKVVGVDLIEMATKAMLDLPIVPYPGERLPEDYCAVKVPQFSFSRLAGADPVLGVEMASTGEVATFGKNKYEAYLKSLISTGFKLPKKNILFSIGSFKEKQELLPSIAKLHELGYKIFATAGTADFIKEHGIPVHYLEVLSKDEDQKSEYNLSQHLANNLIDLYVNLPSANRFRRPASYMSKGYESRRMAVDYAVPLVTNVKNAKLLVEAIARNISLEVSNRDAQTSHGTAILPGLINITSFATSFDDFEQTTKESLAAGFTFNAFLPHTQAGASVTDYRSLIDAIDAVGASAYTDYSVSIAASETNSQSVSDAADNAGSLFLPFNDFANSKVSALTAQFSSWPNNKPIITDAKTTDLASVLLLASLYNRSIHITGVSSKEDLDLIKMAKEKTLQVTCDVAVHSLFLSKDELDYPFLPNKQDQEYLWENLKDVDCFSIGVLPYLIAKASGTEIAPGMGIKEAVPLLLTAVKAGKLTIGDIVSKFHDNPAKIFNLPKQDAQVVLDLDRFATVEPVYPEFSKLRLRGAVERVSFHNETVVLDGSVLSQIALGKNEVVPRSRFGSTAGIPESPRLGNKRVSFSSDMRRPSLAPETPEPQPAIFEKLGSELVSQPIAGSLGEIAALSDYIRHNNTFLRNNIISVKDITRSDLHSLFTVAQEMRLAVERQGVLDLLQGRVLATMFYEPSTRTSTSFDAAMQRLGGRVVAVDHGSSSVKKGETLQDTIRTLSCYSDAIVLRHPSEESADIAAKYSPVPIINAGNGTKEHPTQALLDLFTIREELGTVNGITVTFMGDLKYGRPVHSLCHLLRHYQVRVQLVAPKELQIPAEIRQQLIDNNMLIAESEELTKEILARSDVLYCTRVQEERFADKEQYQRLKDTYIVDNKILSNAKQHMCVMHPLPRTNEIREEVDFDQRAAYFRQMRHGLFIRMALLAMVIGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTE1</accession>
    <name>A0A1D8PTE1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_CR07170WA</name>
        <name evidence="4" type="ordered locus">orf19.8351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713091.2">
        <property type="nucleotide sequence ID" value="XM_707998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTE1"/>
    <dbReference type="SMR" id="A0A1D8PTE1"/>
    <dbReference type="STRING" id="237561.A0A1D8PTE1"/>
    <dbReference type="GeneID" id="3645271"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07170WA"/>
    <dbReference type="CGD" id="CAL0000195024">
        <property type="gene designation" value="orf19.8351"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07170W_A"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTE1"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000195024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="282" mass="30457" checksum="9A529E5332106C9F" modified="2017-01-18" version="1">MTFTSFIKPESDPNIIVPTKPFNLSPNIVERFSLKDKVTVITGGAGAIGSAIAEGYAQAGGHVIILDHASSDNGLTKRLSSAYGVKSKFFQIDVTNSQQVQQVISQIDEEFGTIDVFVANAGIAWYTGSILNEDSTPENWRRVFDVNVNGVFYCAKYAGEIFKRNGSGSFIITASMSAHINNVPNYQTCYNSAKAAVMHMAKGLAVEFAGFARVNSVSPGYTNTLLSEPIPKPQRAKWWGLTPMGREAETDELVGAYLYLASDASSFTNGSDIRVDGGYCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PUA1</accession>
    <name>A0A1D8PUA1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BPL1</name>
        <name evidence="3" type="ordered locus">CAALFM_CR10620CA</name>
        <name evidence="2" type="ordered locus">orf19.7645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719404.1">
        <property type="nucleotide sequence ID" value="XM_714311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PUA1"/>
    <dbReference type="SMR" id="A0A1D8PUA1"/>
    <dbReference type="FunCoup" id="A0A1D8PUA1">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PUA1"/>
    <dbReference type="GeneID" id="3639006"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10620CA"/>
    <dbReference type="CGD" id="CAL0000192734">
        <property type="gene designation" value="BPL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10620C_A"/>
    <dbReference type="eggNOG" id="KOG1536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PUA1"/>
    <dbReference type="OMA" id="HHAFYSN"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="363"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000192734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="665" mass="73544" checksum="8B3035D9990F2510" modified="2017-01-18" version="1">MNVLVYSGPGTTTEGVKHCLETLRLHLGSYYAVLPVNETVLLNEPWMRKTSLLVIPGGADLPYCNVLDGNGTRKISKYVKQGGKFLGLCAGGYFGSARCEFEVGNPTMEVTGPRELGFFPGTAKGCAFKGFKYESRTGARAVKLSVNTAALPGCASHIYNYYDGGAVFANAEKYKDVEILARYDDKTDIVDLEKAAVVYRKVGKGGVILSGTHPEFAPHLLHPRDEDGAGYFIVVDTLRAYDHNKKVFMRDCLKKLGLRVAESVDTTIPRVTPMYVVSPFKDKVRDVYSILTSKLGKSFEDSNDAFYFADETQETSEYVGSEEDPVKYINFLTSAGIPDLKMVPYFDIQKYFDNLRMLSGGDIKFGSILGYSEVITSTNTIMDKNPQWLEHLPNGFTITATTQIAGRGRGGNVWVNPRGVLATSVLFKIPPSPSSSSTVVTLQYLCGLALIESILGYGSNVSGQGVGYEDMPLRLKWPNDIFIMKPEYFKSLDDKSDISATVDGDDEKFVKVSGALINSQFINKTFYLVWGGGVNVSNPAPTTSLNLVLEKLNEIRRGKGLSPLPPYEPEILLAKLMFTIDQFYSVFEKSGLQPFLPLYYKRWFHTNQKVDVDNGSGKQRTCIIKGITPDYGLLIAEDVETKKVLHLQPDGNSFDIFKGLVYKKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2025-06-18" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>P30418</accession>
    <accession>A0A1D8PLA8</accession>
    <accession>Q5AMK5</accession>
    <name>NMT_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 4 5">2.3.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Myristoyl-CoA:protein N-myristoyltransferase</fullName>
            <shortName>NMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Peptide N-myristoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NMT1</name>
        <name type="ordered locus">CAALFM_C401440WA</name>
        <name type="ORF">CaO19.12111</name>
        <name type="ORF">CaO19.4641</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Biol. Chem." volume="267" first="8591" last="8598">
            <title>The Candida albicans myristoyl-CoA:protein N-myristoyltransferase gene. Isolation and expression in Saccharomyces cerevisiae and Escherichia coli.</title>
            <authorList>
                <person name="Wiegand R.C."/>
                <person name="Carr C."/>
                <person name="Minnerly J.C."/>
                <person name="Pauley A.M."/>
                <person name="Carron C.P."/>
                <person name="Langner C.A."/>
                <person name="Duronio R.J."/>
                <person name="Gordon J.I."/>
            </authorList>
            <dbReference type="PubMed" id="1569105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 121-132; 291-300; 341-359 AND 408-423</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>ATCC 32354 / B311</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1994" name="J. Biol. Chem." volume="269" first="2996" last="3009">
            <title>Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans.</title>
            <authorList>
                <person name="Lodge J.K."/>
                <person name="Johnson R.L."/>
                <person name="Weinberg R.A."/>
                <person name="Gordon J.I."/>
            </authorList>
            <dbReference type="PubMed" id="8300631"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-447</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="11874" last="11880">
            <title>Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.</title>
            <authorList>
                <person name="McWherter C.A."/>
                <person name="Rocque W.J."/>
                <person name="Zupec M.E."/>
                <person name="Freeman S.K."/>
                <person name="Brown D.L."/>
                <person name="Devadas B."/>
                <person name="Getman D.P."/>
                <person name="Sikorski J.A."/>
                <person name="Gordon J.I."/>
            </authorList>
            <dbReference type="PubMed" id="9115247"/>
            <dbReference type="DOI" id="10.1074/jbc.272.18.11874"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1998" name="Nat. Struct. Biol." volume="5" first="213" last="221">
            <title>Crystal structure of the anti-fungal target N-myristoyl transferase.</title>
            <authorList>
                <person name="Weston S.A."/>
                <person name="Camble R."/>
                <person name="Colls J."/>
                <person name="Rosenbrock G."/>
                <person name="Taylor I."/>
                <person name="Egerton M."/>
                <person name="Tucker A.D."/>
                <person name="Tunnicliffe A."/>
                <person name="Mistry A."/>
                <person name="Mancia F."/>
                <person name="de la Fortelle E."/>
                <person name="Irwin J."/>
                <person name="Bricogne G."/>
                <person name="Pauptit R.A."/>
            </authorList>
            <dbReference type="PubMed" id="9501915"/>
            <dbReference type="DOI" id="10.1038/nsb0398-213"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS)</scope>
    </reference>
    <reference evidence="7 8" key="8">
        <citation type="journal article" date="2002" name="Chem. Biol." volume="9" first="1119" last="1128">
            <title>Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.</title>
            <authorList>
                <person name="Sogabe S."/>
                <person name="Masubuchi M."/>
                <person name="Sakata K."/>
                <person name="Fukami T.A."/>
                <person name="Morikami K."/>
                <person name="Shiratori Y."/>
                <person name="Ebiike H."/>
                <person name="Kawasaki K."/>
                <person name="Aoki Y."/>
                <person name="Shimma N."/>
                <person name="D'Arcy A."/>
                <person name="Winkler F.K."/>
                <person name="Banner D.W."/>
                <person name="Ohtsuka T."/>
            </authorList>
            <dbReference type="PubMed" id="12401496"/>
            <dbReference type="DOI" id="10.1016/S1074-5521(02)00240-5"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 60-451 IN COMPLEXES WITH MYRISTOYL-COA AND INHIBITORS</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. Basic residues are preferred at positions 7 and 8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4 5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text>Competitively inhibited by SC-58272, a peptidomimetic derived from the N-terminal sequence of a natural substrate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Has an ordered Bi-Bi kinetic mechanism, with myristoyl-CoA binding taking place prior to peptide binding and CoA release occurring before acylated peptide release. Cooperative interactions between the acyl-CoA and peptide binding sites of NMT contribute to its extraordinary chain-length specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 4 5"/>
    <dbReference type="EMBL" id="M80544">
        <property type="protein sequence ID" value="AAA34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A38099">
        <property type="entry name" value="A38099"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722713.1">
        <property type="nucleotide sequence ID" value="XM_717620.2"/>
    </dbReference>
    <dbReference type="PDB" id="1IYK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B=60-451"/>
    </dbReference>
    <dbReference type="PDB" id="1IYL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A/B/C/D=60-451"/>
    </dbReference>
    <dbReference type="PDB" id="1NMT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A/B/C=60-451"/>
    </dbReference>
    <dbReference type="PDBsum" id="1IYK"/>
    <dbReference type="PDBsum" id="1IYL"/>
    <dbReference type="PDBsum" id="1NMT"/>
    <dbReference type="AlphaFoldDB" id="P30418"/>
    <dbReference type="SMR" id="P30418"/>
    <dbReference type="BioGRID" id="1218551">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="P30418">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P30418"/>
    <dbReference type="BindingDB" id="P30418"/>
    <dbReference type="ChEMBL" id="CHEMBL3548"/>
    <dbReference type="DrugBank" id="DB03062">
        <property type="generic name" value="(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone"/>
    </dbReference>
    <dbReference type="DrugBank" id="DB02180">
        <property type="generic name" value="Myristoyl-Coa"/>
    </dbReference>
    <dbReference type="DrugBank" id="DB02477">
        <property type="generic name" value="N-({4-[4-(2-Methyl-1H-imidazol-1-yl)butyl]phenyl}acetyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_01440W_A-T">
        <property type="protein sequence ID" value="C4_01440W_A-T-p1"/>
        <property type="gene ID" value="C4_01440W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635624"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401440WA"/>
    <dbReference type="CGD" id="CAL0000201559">
        <property type="gene designation" value="NMT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01440W_A"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022882_1_0_1"/>
    <dbReference type="InParanoid" id="P30418"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="BRENDA" id="2.3.1.97">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="P30418"/>
    <dbReference type="PRO" id="PR:P30418"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000064236" description="Glycylpeptide N-tetradecanoyltransferase">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Causes temperature-dependent reduction in catalytic activity." evidence="4">
        <original>G</original>
        <variation>D</variation>
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="turn" evidence="9">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="turn" evidence="9">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="turn" evidence="9">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="232"/>
            <end position="237"/>
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    <evidence type="ECO:0000250" key="1"/>
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        <source>
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        <source>
            <dbReference type="PubMed" id="9115247"/>
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    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="1IYK"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="1IYL"/>
        </source>
    </evidence>
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            <dbReference type="PDB" id="1IYK"/>
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    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="1IYL"/>
        </source>
    </evidence>
    <sequence length="451" mass="51863" checksum="7D106E2C08D5922D" modified="2017-03-15" version="2">MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEEGPIDKLKTPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYSHEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIHKKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGFSHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEFKHWMLGHDENSDSNVVKSYVVEDENGVITDYFSYYLLPFTVLDNAQHDELGIAYLFYYASDSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLFNYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2025-04-09" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>P46589</accession>
    <accession>A0A1D8PKL9</accession>
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            <fullName>Adherence factor</fullName>
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        <name type="primary">ADF1</name>
        <name type="synonym">AAF1</name>
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        <name type="ORF">CaO19.7436</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1996-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jiang W."/>
                <person name="Finkler A."/>
                <person name="Koltin Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="1994-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Edwards J.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-612</scope>
        <source>
            <strain>ATCC 36082</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
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        <text>Surface antigen mediating adhesion and aggregation in S.cerevisiae.</text>
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        <variation>N</variation>
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            <position position="142"/>
        </location>
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    <feature type="sequence conflict" description="In Ref. 5; AAA62506." evidence="2" ref="5">
        <original>T</original>
        <variation>I</variation>
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="612" mass="68794" checksum="77B60E45C35C1B23" modified="1996-10-01" version="2">MSSFNSNSNPANAQNLSSFQFQPPKEDVIFDTHQMSLSVPQSRYYASSMMQQSQQGQPQSQTSQQQQQQPFLMNIPPAFTQTQPQQMLYAMPPLQTQQPSSSSATTNNVVPPHHYNQQQSQQQQQQQQQYQQMQPQPNNMQFFDNTIPNYLIMNQTISPSQTQTTAQPNISYYNYSTQPQLQSAQPISHSQPQPQPQATQPRSNRSRSQTSFSKPRGSRQVSGSGRSTGAKKQSAITSGSTGTGPARNADTGMTSVANSTSTTTMTTTNNNNKLSVSAPVNVIYANLPERLQQVLPAPPLSRAPVRPDVTVNLTSKRAKRKSKFTPEQDDMIVNLKKKGKSWVEIAEITGVGSYLAARNRFQVIVGQQGNNNSSAWDNTDKLFLNQLLDAGEIEKWRFICCELNKSTNKNFTDYECREMIRQLFWLNPASFGVNEETIIESQKEKKLTEKTIEQREQQRKKRASANHSPPDSDSITNTNNNQQEVKYIDPQYKNYQSQLMPNQNTGSGATKISSTTPPPPSQALSNNVNTMNKNIVSSALGGTSFSQEQHSLHSNQHHHNHQQHPLIHHHQYQQQSSLPPPPTIPSTIPTSSLSIQQQQQQQQQQLYNKQFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2025-06-18" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q04782</accession>
    <accession>A0A1D8PGL9</accession>
    <accession>Q5AM05</accession>
    <name>ERG7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lanosterol synthase</fullName>
            <ecNumber evidence="6">5.4.99.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,3-epoxysqualene--lanosterol cyclase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ergosterol biosynthesis protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Oxidosqualene--lanosterol cyclase</fullName>
            <shortName evidence="8">OSC</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ERG7</name>
        <name type="ordered locus">CAALFM_C202460WA</name>
        <name type="ORF">CaO19.1570</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Gene" volume="127" first="149" last="150">
            <title>Sequence of the Candida albicans erg7 gene.</title>
            <authorList>
                <person name="Roessner C.A."/>
                <person name="Min C."/>
                <person name="Hardin S.H."/>
                <person name="Harris-Haller L.W."/>
                <person name="McCollum J.C."/>
                <person name="Scott A.I."/>
            </authorList>
            <dbReference type="PubMed" id="8486282"/>
            <dbReference type="DOI" id="10.1016/0378-1119(93)90631-C"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1990" name="Gene" volume="87" first="177" last="183">
            <title>Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicans.</title>
            <authorList>
                <person name="Kelly R."/>
                <person name="Miller S.M."/>
                <person name="Lai M.H."/>
                <person name="Kirsch D.R."/>
            </authorList>
            <dbReference type="PubMed" id="2185141"/>
            <dbReference type="DOI" id="10.1016/0378-1119(90)90299-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Med. Mycol." volume="42" first="385" last="389">
            <title>Ergosterol gene expression in wild-type and ergosterol-deficient mutants of Candida albicans.</title>
            <authorList>
                <person name="Pierson C.A."/>
                <person name="Eckstein J."/>
                <person name="Barbuch R."/>
                <person name="Bard M."/>
            </authorList>
            <dbReference type="PubMed" id="15473366"/>
            <dbReference type="DOI" id="10.1080/13693780410001712016"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="J. Antimicrob. Chemother." volume="55" first="645" last="654">
            <title>Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.</title>
            <authorList>
                <person name="Copping V.M.S."/>
                <person name="Barelle C.J."/>
                <person name="Hube B."/>
                <person name="Gow N.A.R."/>
                <person name="Brown A.J.P."/>
                <person name="Odds F.C."/>
            </authorList>
            <dbReference type="PubMed" id="15820985"/>
            <dbReference type="DOI" id="10.1093/jac/dki088"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 10">Lanosterol synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:2185141, PubMed:8486282). ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core (PubMed:2185141). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-2,3-epoxysqualene = lanosterol</text>
            <dbReference type="Rhea" id="RHEA:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="EC" id="5.4.99.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:14622"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Predominantly in lipid particles.</text>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Expression is induced in the presence of fluconazole (PubMed:15820985). Expression is up-regulated when ERG6, CYP51/ERG11 or ERG24 are deleted (PubMed:15473366).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.7" evidence="6"/>
    <dbReference type="EMBL" id="L04305">
        <property type="protein sequence ID" value="AAA34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JN0664">
        <property type="entry name" value="JN0664"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722612.2">
        <property type="nucleotide sequence ID" value="XM_717519.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q04782"/>
    <dbReference type="SMR" id="Q04782"/>
    <dbReference type="BioGRID" id="1218855">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q04782">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q04782"/>
    <dbReference type="BindingDB" id="Q04782"/>
    <dbReference type="ChEMBL" id="CHEMBL1075056"/>
    <dbReference type="DrugBank" id="DB00239">
        <property type="generic name" value="Oxiconazole"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C2_02460W_A-T">
        <property type="protein sequence ID" value="C2_02460W_A-T-p1"/>
        <property type="gene ID" value="C2_02460W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635761"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202460WA"/>
    <dbReference type="CGD" id="CAL0000184383">
        <property type="gene designation" value="ERG7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02460W_A"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="InParanoid" id="Q04782"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00753"/>
    </dbReference>
    <dbReference type="PRO" id="PR:Q04782"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000027">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0551">Lipid droplet</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="chain" id="PRO_0000072654" description="Lanosterol synthase">
        <location>
            <begin position="1"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="PFTB 1" evidence="3">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="PFTB 2" evidence="3">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="PFTB 3" evidence="3">
        <location>
            <begin position="611"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA34342." evidence="10" ref="1">
        <original>PD</original>
        <variation>SG</variation>
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P48449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15473366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15820985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="2185141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="8486282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="2185141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="8486282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <sequence length="728" mass="83783" checksum="1449ACB621540255" modified="2017-03-15" version="2">MYYSEEIGLPKTDISRWRLRSDALGRETWHYLSQSECESEPQSTFVQWLLESPDFPSPPSSDIHTPDEAARKGADFLKLLQLDNGIFPCQYKGPMFMTIGYVTANYYSKTEIPEPYRVEMIRYIVNTAHPVDGGWGLHSVDKSTCFGTTMNYVCLRLLGMEKDHPVLVKARKTLHRLGGAIKNPHWGKAWLSILNLYEWEGVNPAPPELWRLPYWLPIHPAKWWVHTRAIYLPLGYTSANRVQCELDPLLKEIRNEIYVPSQLPYESIKFGNQRNNVCGVDLYYPHTKILDFANSILSKWEAVRPKWLLNWVNKKVYDLIVKEYQNTEYLCIAPVSFAFNMVVTCHYEGSESENFKKLQNRMNDVLFHGPQGMTVMGTNGVQVWDAAFMVQYFFMTGLVDDPKYHDMIRKSYLFLVRSQFTENCVDGSFRDRRKGAWPFSTKEQGYTVSDCTAEAMKAIIMVRNHASFADIRDEIKDENLFDAVEVLLQIQNVGEWEYGSFSTYEGIKAPLLLEKLNPAEVFNNIMVEYPYVECTDSSVLGLTYFAKYYPDYKPELIQKTISSAIQYILDSQDNIDGSWYGCWGICYTYASMFALEALHTVGLDYESSSAVKKGCDFLISKQLPDGGWSESMKGCETHSYVNGENSLVVQSAWALIGLILGNYPDEEPIKRGIQFLMKRQLPTGEWKYEDIEGVFNHSCAIEYPSYRFLFPIKALGLYKNKYGDKVLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q3MPQ4</accession>
    <accession>A0A1D8PQP5</accession>
    <accession>Q5AFM9</accession>
    <accession>Q5AFN0</accession>
    <name>MVP1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MVP1</name>
        <name type="ordered locus">CAALFM_C700790WA</name>
        <name type="ORF">CaJ7.0093</name>
        <name type="ORF">CaO19.7038</name>
        <name type="ORF">CaO19.7039</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword id="KW-0653">Protein transport</keyword>
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            <position position="369"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KZ2</accession>
    <accession>Q9C475</accession>
    <name>Q59KZ2_CANAL</name>
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        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
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        <name evidence="9" type="ordered locus">CAALFM_C104410CA</name>
        <name evidence="8" type="ordered locus">orf19.12663</name>
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    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2005" name="Biochemistry" volume="44" first="6180" last="6189">
            <title>The structure of the Candida albicans Ess1 prolyl isomerase reveals a well-ordered linker that restricts domain mobility.</title>
            <authorList>
                <person name="Li Z."/>
                <person name="Li H."/>
                <person name="Devasahayam G."/>
                <person name="Gemmill T."/>
                <person name="Chaturvedi V."/>
                <person name="Hanes S.D."/>
                <person name="Van Roey P."/>
            </authorList>
            <dbReference type="PubMed" id="15835905"/>
            <dbReference type="DOI" id="10.1021/bi050115l"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
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        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_705312.1"/>
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        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A=1-177"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04410C_A"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="EvolutionaryTrace" id="Q59KZ2"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:RNA polymerase II complex binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:cellular response to heat"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to heat"/>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:positive regulation of rDNA heterochromatin formation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:termination of RNA polymerase II transcription"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PPIase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
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    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
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    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
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        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="65"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000196636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="1YW5"/>
        </source>
    </evidence>
    <sequence length="177" mass="19855" checksum="ABAE035D939E778E" modified="2005-04-26" version="1">MASTSTGLPPNWTIRVSRSHNKEYFLNQSTNESSWDPPYGTDKEVLNAYIAKFKNNGYKPLVNEDGQVRVSHLLIKNNQSRKPKSWKSPDGISRTRDESIQILKKHLERILSGEVKLSELANTESDCSSHDRGGDLGFFSKGQMQPPFEEAAFNLHVGEVSNIIETNSGVHILQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LK8</accession>
    <name>Q59LK8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C204770WA</name>
        <name evidence="3" type="ordered locus">orf19.7820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710617.1">
        <property type="nucleotide sequence ID" value="XM_705525.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LK8"/>
    <dbReference type="STRING" id="237561.Q59LK8"/>
    <dbReference type="GeneID" id="3647783"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204770WA"/>
    <dbReference type="CGD" id="CAL0000188814">
        <property type="gene designation" value="orf19.7820"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04770W_A"/>
    <dbReference type="HOGENOM" id="CLU_856737_0_0_1"/>
    <dbReference type="InParanoid" id="Q59LK8"/>
    <dbReference type="OrthoDB" id="4097064at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000188814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="324" mass="38130" checksum="A567BCE1CD43A9C0" modified="2005-04-26" version="1" fragment="single">MAPRIRRRITTSKREEIEKEQEELSKTIIRPYDVLQSLPVSYSQPPTSTSSIFTHPLTIKDTGTLYYSLIKSRNNYLTMCPMFKLFWVKQSSYVRKLLELDKPLPKSMENDIYLNREMVLNNDSSARDIMVKLCDGGLSFSSGIHSFEIRIFIAKDKRSDINEIKLIKQREKELKKINKLKEKELKDKLREENRLIKEQERLERLKEKELEKQLKQKQKEEKQKQKEQREKERELEREKKEKEKKEKEKEKERKDKEKEKKDKEKSSQSKGTGNNVKDTLIVGVIQKSSIGNQKEVGTGDASTSKTSQSKKKQTAKQLNSKDTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S59</accession>
    <accession>A0A1D8PPW0</accession>
    <name>MRH4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase MRH4, mitochondrial</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MRH4</name>
        <name type="ordered locus">CAALFM_C602380WA</name>
        <name type="ORF">CaO19.10985</name>
        <name type="ORF">CaO19.3481</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. MRH4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712520.2">
        <property type="nucleotide sequence ID" value="XM_707427.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S59"/>
    <dbReference type="SMR" id="Q59S59"/>
    <dbReference type="FunCoup" id="Q59S59">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59S59"/>
    <dbReference type="EnsemblFungi" id="C6_02380W_A-T">
        <property type="protein sequence ID" value="C6_02380W_A-T-p1"/>
        <property type="gene ID" value="C6_02380W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645883"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602380WA"/>
    <dbReference type="CGD" id="CAL0000186407">
        <property type="gene designation" value="orf19.10985"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02380W_A"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_18_0_1"/>
    <dbReference type="InParanoid" id="Q59S59"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="PRO" id="PR:Q59S59"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990400">
        <property type="term" value="F:mitochondrial ribosomal large subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000232350" description="ATP-dependent RNA helicase MRH4, mitochondrial">
        <location>
            <begin position="26"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="144"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="395"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="555" mass="62499" checksum="64F8417AB7C11882" modified="2017-03-15" version="2" precursor="true">MFKLLIPNKYNYVIRPLVRFKSIKSPKSPKPKPTAKLSPNVFSSGKFSQLHNDTSTTNIESKITSFDQLKIFPSVREAMIKEIKSQYNLKGPRHSNIDEIDIKPTPVQIAAIRKINQTRKLKVPNKDLEGMDDAERIQFELQNANEIQKTKVFTVAAETGSGKTWSYLAPLLSKLKSDDMEFWKSDPEGYDNTRKKGQFVKSVILLPTNELVDQVYETLQRANSFELDHKGAPGNFTSFLELPENKTMNITTMKLGQGEAPVRLFRQLETKGPIDVLITTPGKIVAFSKLVNINRPFRVFANVKYCVLDEADTLFDDSFEKNTTDVITHFPKLLDLILVSATIPKVFEKKLSKLFPDQRSLIRVATPSLHKVPRNIKVMTIDADVAPYNGSKPRCLAQALYAISKDGTEPGYVKRIIVFVNEKSEVDGIVESMITKYKVRPEDIVGVSGSVNIRDRKDMLQPFLQPAELIENDDFGSKVKILVTTDLLARGLNFQGVKNVILLGLPRNSVDLVHRLGRTGRMNQNGRVFVIVDKKSKKSWVKGLGNAIIRGLRIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UG4</accession>
    <accession>A0A1D8PSE6</accession>
    <accession>Q59UL7</accession>
    <name>SQS1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SQS1</name>
        <name type="ordered locus">CAALFM_CR03230WA</name>
        <name type="ORF">CaO19.2400</name>
        <name type="ORF">CaO19.9936</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SQS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713233.1">
        <property type="nucleotide sequence ID" value="XM_708140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UG4"/>
    <dbReference type="SMR" id="Q59UG4"/>
    <dbReference type="FunCoup" id="Q59UG4">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59UG4"/>
    <dbReference type="EnsemblFungi" id="CR_03230W_A-T">
        <property type="protein sequence ID" value="CR_03230W_A-T-p1"/>
        <property type="gene ID" value="CR_03230W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645127"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03230WA"/>
    <dbReference type="CGD" id="CAL0000180348">
        <property type="gene designation" value="orf19.9937"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03230W_A"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021974_1_0_1"/>
    <dbReference type="InParanoid" id="Q59UG4"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="PRO" id="PR:Q59UG4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000324994" description="Protein SQS1">
        <location>
            <begin position="1"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="R3H">
        <location>
            <begin position="530"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="662"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="705" mass="80496" checksum="DC0F8099EDD8E7B7" modified="2005-04-26" version="1">MPKRGNRRRRGGTGGSGGGRGGRGGSRGRGGGRRTPSGANRGRHPSRGNKNRSPRTITQYGDLMDDDNIFIPKTMSEVASNMGRRKYGGMFEEIEYTESHQEDLMSRQLRNRPVEFVKAKEVYDPNVILYKLAKLNNKDDGIDIAVQSISLDDSENESSTNKVDISSSEEIEESGDEYEDEQDDEDDWDEEELHNEITTKLEALEEAMNNVSSDTESEQSVSHIEEEDEKVESHIPEPDLSAEVDEPLQEIDESENENQMESEVGTNTNTQDIETLDIIIDLPSNKVESHMSHSLPQKFKTPSSPDDDNDDNNNNSTPESEPEYGYLEEDYEFDVSKIEVSNVRFGIENQYHIKCMELTGSIDEYIWIDENDVIEYVLDNGVKEHRLNKFLSFITKGMIDEQEPEPEPEVYISDSNSEEEEEEEDDYNSEQDDYPYDSDDNLEDLIAYSKTSTQGLIPFEDRDFSNNIPSKKRQTFDHLDFDDDGELQDSLIRQLNNYKANKKLKKHQWEQQKLEESILHHDMLIKYPVSLHIKDIKSEFDQLLKDESRQSMSFPTLDTHGHKTIKNLADCYHMSVIKSGKQGIRKYLKIVKNKATFKYYPNYERINRILRGRPIFHRIDQKPQHKKGEKSKSKSSRGDASSSRARFKEGDIVGAEAPEIGSSNLGRQMLEKLGWIQGQGLGVDGNKGINEPILAKVKTSKTGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q59US6</accession>
    <name>Q59US6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C400190WA</name>
        <name evidence="2" type="ordered locus">orf19.13089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713325.1">
        <property type="nucleotide sequence ID" value="XM_708232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59US6"/>
    <dbReference type="FunCoup" id="Q59US6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59US6"/>
    <dbReference type="GeneID" id="3645030"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400190WA"/>
    <dbReference type="CGD" id="CAL0000199537">
        <property type="gene designation" value="orf19.13089"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00190W_A"/>
    <dbReference type="HOGENOM" id="CLU_855293_0_0_1"/>
    <dbReference type="InParanoid" id="Q59US6"/>
    <dbReference type="OrthoDB" id="4073891at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
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        <location>
            <begin position="232"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199537"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28812.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="305" mass="35009" checksum="FFCD4BB8BA3574C4" modified="2005-04-26" version="1">MNKEEIYTIRPTRSKLLIVWSILELCTVSLLFAMSFFFLFANSKLIQRGPPAFQLRIQSDSIFAKNTFQLVQQGLKFATYLSNDLNIYINETIPETYLQQIDSNYDNNLYQFNVFGFCRKTQFDKILNCYNGQGINIAACFLQDIGTQLGNLTNQADPSNVSAKLVSFYYNLVDQICSDSDKKLCALQTYNTMSRIVQYLGISSLICLAVTTATSFFEMIGYCVFAKSLARVFFIVKVISMLVFVFTICILYCIIMVMKNFLTDLITQFQIGTLEFPSIKWITWGVLTLMCLIIVVKRYLIYQSI</sequence>
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    <accession>Q59V73</accession>
    <name>Q59V73_CANAL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">orf19.11360</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW31333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59V73"/>
    <dbReference type="SMR" id="Q59V73"/>
    <dbReference type="GeneID" id="3644854"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06270WA"/>
    <dbReference type="CGD" id="CAL0000200112">
        <property type="gene designation" value="orf19.11360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06270W_A"/>
    <dbReference type="HOGENOM" id="CLU_107653_0_0_1"/>
    <dbReference type="InParanoid" id="Q59V73"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000200112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="164" mass="18619" checksum="E4F10205175E268E" modified="2005-04-26" version="1">MVPKIDAYFYGYDTFDPKIDANYLKNSGVNFDSLFLYEFMHVKELPTVITSLKLIGTTLDSYVIDGLKKLSLESSGDGNTTKEYSFPSSLEDLTIKGYKLTRITLPPNLRRLYISTFSKSVDFVSVEMPHLEYLSLSLSDVKNLEDTGICAPNLKTLEIHNRLR</sequence>
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<entry dataset="Swiss-Prot" created="2013-11-13" modified="2025-06-18" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VX8</accession>
    <accession>A0A1D8PCP5</accession>
    <name>SHS1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Septation protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Seventh homolog of septin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SEP7</name>
        <name type="synonym">SHS1</name>
        <name type="ordered locus">CAALFM_C102230WA</name>
        <name type="ORF">CaO19.11164</name>
        <name type="ORF">CaO19.3680</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Mol. Biol. Cell" volume="13" first="2732" last="2746">
            <title>Septin function in Candida albicans morphogenesis.</title>
            <authorList>
                <person name="Warenda A.J."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="12181342"/>
            <dbReference type="DOI" id="10.1091/mbc.E02-01-0013"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Infect. Immun." volume="71" first="4045" last="4051">
            <title>Candida albicans septin mutants are defective for invasive growth and virulence.</title>
            <authorList>
                <person name="Warenda A.J."/>
                <person name="Kauffman S."/>
                <person name="Sherrill T.P."/>
                <person name="Becker J.M."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="12819094"/>
            <dbReference type="DOI" id="10.1128/IAI.71.7.4045-4051.2003"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="Yeast" volume="21" first="1025" last="1033">
            <title>Tandem affinity purification of the Candida albicans septin protein complex.</title>
            <authorList>
                <person name="Kaneko A."/>
                <person name="Umeyama T."/>
                <person name="Hanaoka N."/>
                <person name="Monk B.C."/>
                <person name="Uehara Y."/>
                <person name="Niimi M."/>
            </authorList>
            <dbReference type="PubMed" id="15449307"/>
            <dbReference type="DOI" id="10.1002/yea.1147"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>IDENTIFICATION IN THE SEPTIN COMPLEX</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="1509" last="1518">
            <title>Sep7 is essential to modify septin ring dynamics and inhibit cell separation during Candida albicans hyphal growth.</title>
            <authorList>
                <person name="Gonzalez-Novo A."/>
                <person name="Correa-Bordes J."/>
                <person name="Labrador L."/>
                <person name="Sanchez M."/>
                <person name="Vazquez de Aldana C.R."/>
                <person name="Jimenez J."/>
            </authorList>
            <dbReference type="PubMed" id="18234840"/>
            <dbReference type="DOI" id="10.1091/mbc.E07-09-0876"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="J. Cell Sci." volume="125" first="2533" last="2543">
            <title>CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4.</title>
            <authorList>
                <person name="Li C.R."/>
                <person name="Yong J.Y."/>
                <person name="Wang Y.M."/>
                <person name="Wang Y."/>
            </authorList>
            <dbReference type="PubMed" id="22366454"/>
            <dbReference type="DOI" id="10.1242/jcs.104497"/>
        </citation>
        <scope>INTERACTION WITH GIN4</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2012" name="Antimicrob. Agents Chemother." volume="56" first="4614" last="4624">
            <title>Rapid redistribution of phosphatidylinositol-(4,5)-bisphosphate and septins during the Candida albicans response to caspofungin.</title>
            <authorList>
                <person name="Badrane H."/>
                <person name="Nguyen M.H."/>
                <person name="Blankenship J.R."/>
                <person name="Cheng S."/>
                <person name="Hao B."/>
                <person name="Mitchell A.P."/>
                <person name="Clancy C.J."/>
            </authorList>
            <dbReference type="PubMed" id="22687514"/>
            <dbReference type="DOI" id="10.1128/AAC.00112-12"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinase GIN4. Septins are also involved in cell morphogenesis, chlamydospores morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation. SEP7 is required to convert hyphal septin rings into the hyphal-specific state and is necessary for CDC10 turnover during hyphal growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Component of the septin complex which consists of CDC3, CDC10, CDC11, CDC12 and probably SEP7. The purified septin complex appeared to have a stoichiometry of 2 CDC3, 1 to 2 CDC10, 1 CDC11, 2 CDC12, and 1 or none SEP7 subunit. Induction of hyphal growth brings about important modifications in septin ring dynamics, because the rings were found in a different state from those of yeast cells. This hyphal-specific state contains a core of stable septins (SEP7, CDC3, and CDC12), and it shows a high CDC10 turnover between the ring and the cytoplasm. Interacts with GIN4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 9">Bud neck</location>
        </subcellularLocation>
        <text>Present at the bud neck during cell division.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7 8">Phosphorylated by GIN4 which stabilizes the GIN4-SEP7 interaction.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to a minor reduction in agar invasion ability.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713774.1">
        <property type="nucleotide sequence ID" value="XM_708681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VX8"/>
    <dbReference type="SMR" id="Q59VX8"/>
    <dbReference type="BioGRID" id="1227690">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59VX8">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VX8"/>
    <dbReference type="EnsemblFungi" id="C1_02230W_A-T">
        <property type="protein sequence ID" value="C1_02230W_A-T-p1"/>
        <property type="gene ID" value="C1_02230W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644596"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102230WA"/>
    <dbReference type="CGD" id="CAL0000186883">
        <property type="gene designation" value="SEP7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02230W_A"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="InParanoid" id="Q59VX8"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PRO" id="PR:Q59VX8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
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    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
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        <property type="term" value="P:division septum assembly"/>
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        <property type="term" value="P:endoplasmic reticulum polarization"/>
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        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
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        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Septin"/>
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    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000424366" description="Septation protein 7">
        <location>
            <begin position="1"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="33"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="3">
        <location>
            <begin position="134"/>
            <end position="137"/>
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    </feature>
    <feature type="region of interest" description="G4 motif" evidence="3">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="472"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <begin position="217"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>GTP</name>
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        <location>
            <position position="306"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12819094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15449307"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="18234840"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="22366454"/>
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    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="22687514"/>
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    </evidence>
    <sequence length="670" mass="75795" checksum="4BE314EF04244B25" modified="2005-04-26" version="1">MSRFDYRNTSKNTSVVDPDHSSPIINYRKDAKKGIKFTFMVVGESGTGKTTFINSLLNKKVLNHRYEKLSPTVGDTKTLMFTSAKSVALPNTSILTKNEFNPRTINEEPGIALTETHIEIIDDDNQKLLLNIIDTPGFGENLNNELCFIEIENYLKQQFDLVLAEETRIKRNPRFVDTRVHVMLYFITPTGHGLREIDIQCMKRLSKYVNIIPVIGKADSFTLNELQHFKQQIRIDIQKFNVPTFQFDNSLNDYDEDEDYDLIQECKFLTNLQPFAVVTSEDVFEVRESTTSTKGNNDKPKIIRARKYPWGLVDINDTRYSDFPILKSVLLGSHLQDLKDLTHDFLYETYRTERLTKVTGNGQAFDDEENEDAEFHDTVEHQLNDSNRGVGGDDNNNNNNNNNNASTIPSMSNLAQLTTSTNEHDASHIDNNSITSTSSSIKKSTSMLIDDHPSSSPKLKNISSFTSSTSTVSLEGGEKEGGHHDRGANSTSTNNNNNNNAFKRLSIGPQRNQLRQISETVPYVLRHERILERQQKLEEMEQASARELANRAALLEKKAAQLKAKEKALRQLELNRQKQEESATSSLHRKDSDISGSVQSGGVDDGKSESTNNNNNNRNGYGYGHGHGHGQSHEYDNSEYHHDDSTPNYETSRLQKDETLTDLHSIVSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q59X53</accession>
    <name>Q59X53_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exosome non-catalytic core subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C209160WA</name>
        <name evidence="7" type="ordered locus">orf19.11559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59X53"/>
    <dbReference type="SMR" id="Q59X53"/>
    <dbReference type="FunCoup" id="Q59X53">
        <property type="interactions" value="979"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59X53"/>
    <dbReference type="GeneID" id="3644090"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209160WA"/>
    <dbReference type="CGD" id="CAL0000176918">
        <property type="gene designation" value="orf19.11559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09160W_A"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_1"/>
    <dbReference type="InParanoid" id="Q59X53"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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    </dbReference>
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        <property type="term" value="P:rRNA catabolic process"/>
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        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:U1 snRNA 3'-end processing"/>
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        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exosome non-catalytic core subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000176918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="337" mass="37793" checksum="1CDEC05630DB78F9" modified="2005-04-26" version="1">MSKELSLNQKNYLIQALKSNIRLSTSTNTGGSRKFNQFRPIDIKLSNTRYGSVELSLGKTKVMVNITSRITEPYQDRPFEGIMTINCEIPNHIKLQSNDTTNNNNDNEDEFINLINRALDRAIRRSNAVDLENLCIIAGEKVWELIIDLQVLNYDGNLIDSGCLAIITALLDFKKPDVTINNNNTSNSSSTSGGGGNIIVHDDEMKRPFIELSILHIPICLTFSLFNLGSKETNLKTNDIDQEIWLLDGDAMEESCRDGYLIMTMNQNHELIQLSKIGGGGNNGGVSIDGQQLINLCHESIDEINRLTNLVKSTVKNHQLNRYNNENYKLLESSADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XS8</accession>
    <name>Q59XS8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,6-mannanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C210020CA</name>
        <name evidence="2" type="ordered locus">orf19.9346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714425.1">
        <property type="nucleotide sequence ID" value="XM_709332.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XS8"/>
    <dbReference type="SMR" id="Q59XS8"/>
    <dbReference type="STRING" id="237561.Q59XS8"/>
    <dbReference type="GeneID" id="3643952"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210020CA"/>
    <dbReference type="CGD" id="CAL0000199331">
        <property type="gene designation" value="orf19.9346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10020C_A"/>
    <dbReference type="eggNOG" id="ENOG502TCPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034119_0_0_1"/>
    <dbReference type="InParanoid" id="Q59XS8"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009971212" description="Alpha-1,6-mannanase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46480" checksum="E6AEDA4B7FE32F3A" modified="2005-04-26" version="1">MQQFLRFILLLLSLISYTTFALTISTTKFLKRGSLPSSSSFDPHDAFEAAINSTWSIFWNDTNQGFSQSDPSCPNSQTSTPFQYSVVWSVAVAGMAIVQSGDISKTNQIITSLYKYQNSQGWFSATPGGGESFVDDNCQVLWVFIEAYELTNNTKYLTTANKLMELIQGQWSDKVGGVKWQVDGDYIASISTVEAALCAVQLYEQNKDDSLLSFAKKCLSWLDDNLLDKSDGFYYDGLNVNNKTNIDKGKLTYTVGVAISTYSYLYKYTNDEQYVLIATAKANETIKSTTFMRSNGYWNNDLKYLHLLFVGIVDLIIIMGDEKSDFSNDIMKQGEFIYKYDQLSEIGNYLDFTGVKQLYDQYVKQSGDNSSINYQFNGDDYCDGSNDSGQIKRSLMENASAAQIFYQLNRLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2025-06-18" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Y20</accession>
    <accession>A0A1D8PI55</accession>
    <name>DSE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Protein DSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Daughter-specific expression protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DSE1</name>
        <name type="ordered locus">CAALFM_C208490WA</name>
        <name type="ORF">CaO19.11112</name>
        <name type="ORF">CaO19.3629</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell wall metabolism and required for the separation of the mother and daughter cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat DSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714471.1">
        <property type="nucleotide sequence ID" value="XM_709378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Y20"/>
    <dbReference type="FunCoup" id="Q59Y20">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Y20"/>
    <dbReference type="EnsemblFungi" id="C2_08490W_A-T">
        <property type="protein sequence ID" value="C2_08490W_A-T-p1"/>
        <property type="gene ID" value="C2_08490W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643899"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208490WA"/>
    <dbReference type="CGD" id="CAL0000181989">
        <property type="gene designation" value="DSE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08490W_A"/>
    <dbReference type="HOGENOM" id="CLU_016851_0_0_1"/>
    <dbReference type="InParanoid" id="Q59Y20"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="PHI-base" id="PHI:3507"/>
    <dbReference type="PRO" id="PR:Q59Y20"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002664">
        <property type="entry name" value="Protein DSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000285345" description="Protein DSE1">
        <location>
            <begin position="1"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="379"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="724" mass="81074" checksum="D374BBA861420E17" modified="2005-04-26" version="1">MTDYYEPTFLFRQNAIKRFSPSLSPISSVESLSLVDSNSISNNGTTTTTTTTTSSIYQNASNSSWLLNPYNVKDTAILNQSCCLNRTNVKSNYWKIPDESMNLTSMSINKNQGGNPILAISSGKSESNLFIYELNLFNNHLIHHHTISLPNIHAMKWINNTRYLVTGNNKGYAHLVSTPKLATHDVFNTNSNGDFDYNDDDEDDNNSAEICKRFNHRKHLKQNQLENTISTPIKHLNFLNNHENLLSIYNDYLFYWDIKGCHQQTRPSPISISTVSGIKNFDVPEKNHSSTNTSSANTVAICGLFGVSLFDLRDCQFNIPNYNTAQIHDKTQSSYRKLSANIVKWNPMNTNILAAGHGDGVIRLWDIRKQDSYIAELYGHNNYSITTSMEWNNNDLFTGSKDGNIIHWDLSNISKDSQWEENDNTKLPISCGLKEGFNSIEFNGKANKLETKLDQYQCGTILPASNSSIVAMCSTTTTTSSNDHDDEEIKILSIDSSSFLGVHNKVSESINVNINTNKLYYTEEDIQLLLQSQLNNNNITSSSATGSNDTLISFGNNVSQDSLVKPLTISRKPTTTIKNNNNNTTTRPTNTHTHSASIDESIVSVHNVSNDTLVNSPTRFNICESEDEFTFNYVKNNTNNEDQRQSDNRNSSFSSVSSQQTQLNNSVESLSTVVTDVENEVNHQEHKYMSLLLPVKDTSTTTTTTKDNNTNSDQAVTNTPIISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Y27</accession>
    <name>Q59Y27_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Anp1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">ANP1</name>
        <name evidence="11" type="ordered locus">CAALFM_C208570WA</name>
        <name evidence="10" type="ordered locus">orf19.11105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714464.1">
        <property type="nucleotide sequence ID" value="XM_709371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Y27"/>
    <dbReference type="SMR" id="Q59Y27"/>
    <dbReference type="FunCoup" id="Q59Y27">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Y27"/>
    <dbReference type="GeneID" id="3643917"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208570WA"/>
    <dbReference type="CGD" id="CAL0000199673">
        <property type="gene designation" value="ANP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08570W_A"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_0_0_1"/>
    <dbReference type="InParanoid" id="Q59Y27"/>
    <dbReference type="OMA" id="EHLPMFF"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000199673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="428" mass="49553" checksum="9B67906F30F12127" modified="2005-04-26" version="1">MFYSLRTLIISIVIGIITLFTIYTQISNSKSGYAPNLSTFDTSQVQFYDLANYKGSANGWQYDERVLFCVPLRDAAPHLPMFFSHMKNLTYPHNLIDLAFLVSDSKDDTMGELKRHLSEIQKDPKLAFGEIEIFEKDFGQVIGQGFSDRHGFAAQGPRRKLMARARNWLWTVAVKPYHSFVYWRDADVETVPPTILEDLMHHDKDVIVPNVWRPLPDWLGNQQPYDLNSWQESEGGLQLADTLDEDACIVEGYVEYQTWRPHLAYLRDPYGDPEVEMDLDGIGGVSILTKANVFRQGSHFPAFSFEKHAETEAFGKLSKRMGFSVVGLPHYVIWHIYEPSSDDLKHMEWMASEEVRQQEEAKIKKVYDKVWNKAFEDVQNNWDKERSKFLKNTDMSNVRKIKVDWSGVDDFDIDKNSHDDKKLADFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YE9</accession>
    <name>Q59YE9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">IPK2</name>
        <name evidence="6" type="ordered locus">CAALFM_C209730CA</name>
        <name evidence="5" type="ordered locus">orf19.8957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714551.1">
        <property type="nucleotide sequence ID" value="XM_709458.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YE9"/>
    <dbReference type="SMR" id="Q59YE9"/>
    <dbReference type="FunCoup" id="Q59YE9">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YE9"/>
    <dbReference type="GeneID" id="3643784"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209730CA"/>
    <dbReference type="CGD" id="CAL0000178674">
        <property type="gene designation" value="IPK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09730C_A"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042569_3_0_1"/>
    <dbReference type="InParanoid" id="Q59YE9"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051766">
        <property type="term" value="F:inositol trisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000827">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000825">
        <property type="term" value="F:inositol-1,3,4,5-tetrakisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000823">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000821">
        <property type="term" value="P:regulation of arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000178674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="350" mass="39511" checksum="7340DB98D34D4D75" modified="2005-04-26" version="1">MIPTLNSLTPSKHQAAGHDGCLATDSLFIKLTVQQEIDFYTQVQSHDQSVQDAPLGSQLSHWMPTFMGTLTQGDVSKTQTAGSDQSSSAEGQTDKQYIVLSNSYHGFTHPSILDIKLGAKLTDDEVTAPEKIARLQKVSDSTTSGSLNFRICGMKVYNGKSDTKPANELYENMNDSSVSVNINDADDHKYLEFNKFYGRSLSKDNIKEGLELYFNNHLPKAIVKRLLVVFHKRLQLLYNCLLDYEVRIFSGSLLFIYESDLTKWENVTEDNYDTYDSLVREIVDDEDEDDEEFEEDSKKDKTQPLTPLSSLNFIDFAHAKFVEGQGHDENIVQGIENLIDIFNALIAKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A102</accession>
    <name>Q5A102_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mismatch repair ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">MSH2</name>
        <name evidence="12" type="ordered locus">CAALFM_C407120CA</name>
        <name evidence="11" type="ordered locus">orf19.10605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715402.1">
        <property type="nucleotide sequence ID" value="XM_710309.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A102"/>
    <dbReference type="SMR" id="Q5A102"/>
    <dbReference type="FunCoup" id="Q5A102">
        <property type="interactions" value="1163"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A102"/>
    <dbReference type="GeneID" id="3642939"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407120CA"/>
    <dbReference type="CGD" id="CAL0000196306">
        <property type="gene designation" value="MSH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07120C_A"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_10_0_1"/>
    <dbReference type="InParanoid" id="Q5A102"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000735">
        <property type="term" value="P:removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000009">
        <property type="entry name" value="Mismatch repair ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000196306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW29433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="873" mass="98321" checksum="8063EDF43D68A18F" modified="2005-04-26" version="1">MSSTKIDLKFSDLADERSYFKKYSQLPPKESTTIRFIDHNNHDYFTALGSDADLIAEKIYRTQSVIKHHNQTKYVTISPQNFKESLNYCLQNHFKVEVYHSKTFQLISSGTAGNLDSLSEEFDIDFDFRDGSSSSIAAIKLGNKVGVCVIADSIVHLSEFEDNELYSNLESLLIQLGVKEVVIPANVDNKKFFQMLEKLNDLVVSAAKSFPKDNEQDISKLLDTENLELSLAAKGINSLDYALALSCCGALIDYLDLLNGDKTFEINKYNLSTFMKLDSSTMKALNILPNGTQKAITSIFELFKCKTLGGSRLLSQWLKQPLIDLSLIEERQELVKAMIDDTSLRVEIQEFLSKVPDINRLLKKIGLGVKRSGAENKKLNEVVNLYQLVSLLPNLTEILTIDYYAKPLKKDEQALSKFCELVETTIDLDTSFDKDYKIKPDFDPSLSEISNNMESAFKAINDLYLEAGDDLNLDTASNKLKLEQHQTHGWCMRVTRNDSRVLRGKSQYKELQTVKSGVFFTTIEMKRLSQEYTKAYDEYNVKQSEVIKEILSLTLTYEPVLQSLSSTLAHLDVITCFATTAMLNSYTQPKLFPFESSRKINLIESRHPLLEVQDDINFISNDVKMDDKHFAIITGPNMGGKSTYIRQIGTIALMAQVGSFIPANDGAELPIFDAILSRVGAGDSQLKGLSTFMIEMLETSSILATATANSLIIIDELGRGTSTYDGFGLAWAISEELIKRKCFAVFATHFHELSQLSEKYDGVENLNLMAEQTNEDITLIYKVGPGISNTSFGISVAEKLHMPEKIVNMAKRKVEELSEEPPIKKQCSETEVREGMSRLREILKEWRNNPEINIADSLAKEPNKFINYIVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1L9</accession>
    <name>Q5A1L9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trx2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">TRX2</name>
        <name evidence="4" type="ordered locus">CAALFM_C500910CA</name>
        <name evidence="3" type="ordered locus">orf19.9532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715738.1">
        <property type="nucleotide sequence ID" value="XM_710645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1L9"/>
    <dbReference type="SMR" id="Q5A1L9"/>
    <dbReference type="STRING" id="237561.Q5A1L9"/>
    <dbReference type="GeneID" id="3642631"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500910CA"/>
    <dbReference type="CGD" id="CAL0000181139">
        <property type="gene designation" value="TRX2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00910C_A"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_4_1"/>
    <dbReference type="InParanoid" id="Q5A1L9"/>
    <dbReference type="OMA" id="FFDECSH"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF3">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000181139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="118" mass="13724" checksum="93E5350380958D79" modified="2005-04-26" version="1">MLQNIETKQQFSSALQNKNDMIVLDFFDECSHCSDLNDKLDEFSDMYEAQNIRFYKVNIEEDRELAEDYKVSSIPTTLFFKKGKVFDKVVGPEPNEIKKVLDKNLMGWSGRPSQSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A4W7</accession>
    <name>Q5A4W7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="21">2.3.1.86</ecNumber>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-hydroxyacyl-[acyl-carrier-protein] dehydratase</fullName>
                <ecNumber evidence="21">4.2.1.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
                <ecNumber evidence="21">1.3.1.9</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">[Acyl-carrier-protein] acetyltransferase</fullName>
                <ecNumber evidence="21">2.3.1.38</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">[Acyl-carrier-protein] malonyltransferase</fullName>
                <ecNumber evidence="21">2.3.1.39</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">S-acyl fatty acid synthase thioesterase</fullName>
                <ecNumber evidence="21">3.1.2.14</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">FAS1</name>
        <name evidence="25" type="ordered locus">CAALFM_C500190CA</name>
        <name evidence="24" type="ordered locus">orf19.8594</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 21">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 21">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 21">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14 21">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="21"/>
    <dbReference type="EC" id="4.2.1.59" evidence="21"/>
    <dbReference type="EC" id="1.3.1.9" evidence="21"/>
    <dbReference type="EC" id="2.3.1.38" evidence="21"/>
    <dbReference type="EC" id="2.3.1.39" evidence="21"/>
    <dbReference type="EC" id="3.1.2.14" evidence="21"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716817.1">
        <property type="nucleotide sequence ID" value="XM_711724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A4W7"/>
    <dbReference type="SMR" id="Q5A4W7"/>
    <dbReference type="FunCoup" id="Q5A4W7">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A4W7"/>
    <dbReference type="GeneID" id="3641593"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500190CA"/>
    <dbReference type="CGD" id="CAL0000183162">
        <property type="gene designation" value="FAS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00190C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="InParanoid" id="Q5A4W7"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 21" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 21" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 21" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9 21" id="KW-0520">NAD</keyword>
    <keyword evidence="7 21" id="KW-0521">NADP</keyword>
    <keyword evidence="8 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="23">
        <location>
            <begin position="1652"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="22">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="22">
        <location>
            <position position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="CGD" id="CAL0000183162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AOW29465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2037" mass="227802" checksum="62C4FE1D35FD3CBE" modified="2005-04-26" version="1">MSTHRPFQLTHGSIEHTLLVPNDLFFNYSQLKDEFIKTLPEPTEGFAGDDEPSSPAELYGKFIGFISNAQFPQIVELSLKDFESRFLDNNNDNIHSFAVKLLDDETYPTTIAKVKENIVKNYYKAVKSINKVESNLLYHCKHDAKLVAIFGGQGNTDDYFEELRELYTLYQGLIEDLLVSIAEKLNQLHPSFDKIYTQGLNILSWLKHPETTPDQDYLLSVPVSCPVICVIQLCHYTITCKVLGLTPGEFRNSLKWSTGHSQGLVTAVTIAASDSWDSFLKNSLTAVSLLLFIGSRCLSTYPRTSLPPTMLQDSLDNGEGRPSPMLSVRDLSIKQVEKFIEQTNSHLPREKHIAISLINGARNLVLSGPPESLYGFNLNLRNQKAPMGLDQSRVPFSERKLKCSNRFLPIFAPFHSHLLADATELILDDVKEHGLSFEGLKIPVYDTFDGSDFQALKEPIIDRVVKLITELPVHWEEATNHKATHILDFGPGGVSGLGVLTHRNKEGTGARIILAGTLDSNPIDDEYGFKHEIFQTSADKAIKWAPDWLKELRPTLVKNSEGKIYVKTKFSQLLGRAPLMVAGMTPTTVNTDIVSASLNAGYHIELAGGGYFSPVMMTRAIDDIVSRIKPGYGLGINLIYVNPFMLQWGIPLIKDLREKGYPIQSLTIGAGVPSIEVATEYIEDLGLTHLGLKPGSVDAISQVIAIAKAHPTFPIVLQWTGGRGGGHHSFEDFHQPIIQMYSKIRRCSNIVLVAGSGFGSDEDTYPYLSGYWSEKFNYPPMPFDGVLFGSRVMTSKESHTSLAAKKLIVECKGVPDQQWEQTYKKPAGGIITVRSEMGEPIHKIATRGVMFWKELDDTIFNLPKNKLLDALNKKRDHIIKKLNNDFQKPWFGKNANGVCDLQEMTYKEVANRLVELMYVKKSHRWIDVSLRNMYGDFLRRVEERFTSSAGTVSLLQNFNQLNEPEQFTADFFVKFPQAGKQLISEEDCDYFLMLAARPGQKPVPFVPVLDERFEFFFKKDSLWQSEDLESVVDEDVQRTCILHGPVASQYTSKVDEPIGDILNSIHEGHIARLIKEEYAGDESKIPVVEYFGGKKPASVSATSVNVTDGNQVVYEIDSELPNKQEWLDLLAGTELNWLQAFISTDRIVQGSKHVSNPLHDILTPAKHSKVTIDKKTKKLTAFENIKGDLLPVVEIELVKPNTIQLSLIEHRTADANPVALPFLYKYNPADGFAPILEIMEDRNERIKEFYWKLWFGSSVPYSNDINVEKAILGDEITISSQTISEFTHAIGNKCDAFVDRPGKATLAPMDFAIVIGWKAIIKAIFPKSVDGDLLKLVHLSNGYKMITGAAPLKKGDVVSTKAEIKAVLNQPSGKLVEVVGTIYREGKPVMEVTSQFLYRGEYNDYCNTFQKVTETPVQVAFKSAKDLAVLRSKEWFHLEKDVQFDVLTFRCESTYKFKSANVYSSIKTTGQVLLELPTKEVIQVGSVDYEAGTSYGNPVTDYLSRNGKTIEESVIFENAIPLSSGEELTSKAPGTNEPYAIVSGDYNPIHVSRVFAAYAKLPGTITHGMYSSASIRALVEEWAANNVAARVRAFKCDFVGMVLPNDTLQTTMEHVGMINGRKIIKVETRNVETELPVLIGEAEIEQPTTTYVFTGQGSQEQGMGMELYNSSEVAREVWDKADRHFVNNYGFSILDIVQNNPNELTIHFGGAKGRAIRDNYIGMMFETIGEDGALKSEKIFKDIDETTTSYTFVSPTGLLSATQFTQPALTLMEKAAYEDIKSKGLIPSDIMFAGHSLGEYSALSSLANVMPIESLVDVVFYRGMTMQVAVPRDELGRSNYGMVAVNPSRVSATFDDSALRFVVDEVANKTKWLLEIVNYNVENQQYVAAGDLRALDTLTNVLNVLKINKIDIVKLQEQMSIEKVKEHLYEIVDEVAAKSLAKPQPIDLERGFAVIPLKGISVPFHSSYLMSGVKPFQRFLCKKIPKSSVKPQDLIGKYIPNLTAKPFELTKEYFQSVYDLTKSEKIKSILDNWEQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A500</accession>
    <name>Q5A500_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">MET14</name>
        <name evidence="15" type="ordered locus">CAALFM_C500430WA</name>
        <name evidence="14" type="ordered locus">orf19.8561</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 12"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716785.1">
        <property type="nucleotide sequence ID" value="XM_711692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A500"/>
    <dbReference type="SMR" id="Q5A500"/>
    <dbReference type="FunCoup" id="Q5A500">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A500"/>
    <dbReference type="GeneID" id="3641547"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500430WA"/>
    <dbReference type="CGD" id="CAL0000184105">
        <property type="gene designation" value="MET14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00430W_A"/>
    <dbReference type="eggNOG" id="KOG0635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A500"/>
    <dbReference type="OMA" id="HENTVEE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000184105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW29487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="200" mass="22537" checksum="5D9973318F9175B6" modified="2005-04-26" version="1">MATNITWHANLTHQERAELRKQKGVTVWLTGLSASGKSTIACALEQSILARGLNSYRLDGDNIRFGLNKDLGFSEADRNENIRRISEVAKLFSDSCCITVTSFISPYRADRRLARELHEKDNLPFVEVYIDVPLEVAEQRDPKGLYKKAREGIIKEFTGISAPYEAPEKAEIHVKNHSGLSVEQAAEQIIDYLLEKGYIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2025-06-18" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A663</accession>
    <name>OMA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial metalloendopeptidase OMA1</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OMA1</name>
        <name type="ordered locus">CAALFM_C404550CA</name>
        <name type="ORF">orf19.3827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Mol. Cell. Biol." volume="36" first="2300" last="2312">
            <title>Oma1 links mitochondrial protein quality control and TOR signaling to modulate physiological plasticity and cellular stress responses.</title>
            <authorList>
                <person name="Bohovych I."/>
                <person name="Kastora S."/>
                <person name="Christianson S."/>
                <person name="Topil D."/>
                <person name="Kim H."/>
                <person name="Fangman T."/>
                <person name="Zhou Y.J."/>
                <person name="Barrientos A."/>
                <person name="Lee J."/>
                <person name="Brown A.J."/>
                <person name="Khalimonchuk O."/>
            </authorList>
            <dbReference type="PubMed" id="27325672"/>
            <dbReference type="DOI" id="10.1128/mcb.00156-16"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5">Protease that is part of the quality control system in the inner membrane of mitochondria (By similarity). Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane protein (By similarity). Required for TOR signaling (PubMed:27325672).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">Protease activity is induced in response to various mitochondrial stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Cells are resistant to rapamycin and display reduced TOR signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717231.1">
        <property type="nucleotide sequence ID" value="XM_712138.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A663"/>
    <dbReference type="SMR" id="Q5A663"/>
    <dbReference type="FunCoup" id="Q5A663">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A663"/>
    <dbReference type="MEROPS" id="M48.018"/>
    <dbReference type="EnsemblFungi" id="C4_04550C_A-T">
        <property type="protein sequence ID" value="C4_04550C_A-T-p1"/>
        <property type="gene ID" value="C4_04550C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641106"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404550CA"/>
    <dbReference type="CGD" id="CAL0000185639">
        <property type="gene designation" value="OMA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04550C_A"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A663"/>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="PHI-base" id="PHI:7048"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000450321" description="Mitochondrial metalloendopeptidase OMA1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="7">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="7">
        <location>
            <begin position="174"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="254"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O75844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P36163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27325672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="27325672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="336" mass="38971" checksum="9444C2A2A305FB01" modified="2005-04-26" version="1">MFGSKIFSRLFFKRTYATYKRFDNTTSSSSFTTSYAHLLTNRKTLYIGGGLLGFYVYNLHDAPYTHRSRFIWVPYWLETKIGDYSYRQIYQQFQSQILPHSNPLYNRVSTIMNKLLDVALNDNINDDLNARFLNHLKSLKWEINIIQNDSLPPNAFILPNGKIFIFSSIMPICKNEDGLATVLSHELSHQLAQHSSEQLSKQPIYMVLSTILYTITGVSWFNDLLINGVLTMSASREMESEADHIGCELLARACFNPQESINFWHRMSQAEKKAAGIVSQEGGYLNTWEFFSTHPATSRRIADIQKWMPQLLQIRESSGCYEYGRFYNFNKSYFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6P2</accession>
    <name>Q5A6P2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="18" type="ordered locus">CAALFM_CR04240CA</name>
        <name evidence="17" type="ordered locus">orf19.8143</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717375.1">
        <property type="nucleotide sequence ID" value="XM_712282.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6P2"/>
    <dbReference type="SMR" id="Q5A6P2"/>
    <dbReference type="FunCoup" id="Q5A6P2">
        <property type="interactions" value="1248"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6P2"/>
    <dbReference type="GeneID" id="3640989"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04240CA"/>
    <dbReference type="CGD" id="CAL0000178904">
        <property type="gene designation" value="orf19.8143"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04240C_A"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A6P2"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="14">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="13">
        <location>
            <begin position="281"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="533"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="16">
        <location>
            <begin position="768"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="997"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="634"/>
            <end position="636"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="641"/>
            <end position="647"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000178904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117329" checksum="F6515974FCA11389" modified="2005-04-26" version="1">MGKKAIDARIPALIRNGVQEKQRSFFIIVGDKARNQLPNLHYLMMSADLKMNKSVLWAYKKKLLGFTSHRQKREAKIKKDIKRGIREVNEQDPFEAFISNQHIRYVYYKETEKILGNTYGMCILQDFEAITPNLLARTIETVEGGGLVVILLKNMTSLKQLYTMSMDIHSRYRTEAHDDVVARFNERFLLSLGSCENCLVVDDELNVLPISGGKHVKPLPPKDDDELTPNAKELKELKESLADVQPAGSLVALSKTINQAQAILTFIDVISEKTLRNTVTLTAGRGRGKSAALGIAIAAAISHGYSNIFVTSPSPENLKTLFEFIFKGFDALGYTEHMDYDIIQSTNPSFNKAIVRVDVKREHRQTIQYISPNDSHVLGQAELLIIDEAAAIPLPIVKKLMGPYLIFMASTINGYEGTGRSLSLKLIQQLRTQSNNATPSETTVVSRDKKSNEITGALTRTLKEVVLDEPIRYAPGDPIEKWLNKLLCLDVSLSKNAKFATKGTPHPSQCQLFYVNRDTLFSYHPVSEAFLQKMMALYVASHYKNSPNDLQLMSDAPAHQLFVLLPPIEAGDNRVPDPLCVIQLALEGEISKESVRKSLSRGQRAGGDLIPWLISQQFQDEEFASLSGARVVRIATNPEYSGMGYGSRAMELLRDYYSGKFTDISESTELNDHTITRVTDSELANASLKDEIKLRDVKTLPPLLLKLSEKAPYYLHYLGVSYGFTSQLHKFWKKAGFTPVYLRQTPNELTGEHTSVVISVLPGREDKWLHEFSKDFHKRFLSLLSYEFKKFQASQALSIIEAAEQGEGDETTSQKLTKEQLDSLLSPFDLKRLDSYANNLLDYHVIVDMLPLISQLFFSKKTGQDISLSSVQSAILLAIGLQHKDMDQIAKELNLPTNQAMAMFAKIIRKFSTYFRKVLSKAIEESMPDLEDENVDAMNGKETEQIDYKAIEQKLQDDLEEAGDEAIKEMREKQRELINALNLDKYAIAEDAEWDEKSMDKATKGKGNVVSIKSGKRKSKENANDIYEKEMKAVKKSKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6Q0</accession>
    <name>Q5A6Q0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARP5</name>
        <name evidence="11" type="ordered locus">CAALFM_CR04180CA</name>
        <name evidence="10" type="ordered locus">orf19.8134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="7">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:enzyme regulator activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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    </dbReference>
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        <property type="entry name" value="Actin"/>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="419"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000201968"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7P6</accession>
    <name>Q5A7P6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C300450CA</name>
        <name evidence="10" type="ordered locus">orf19.12875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_712699.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C300450CA"/>
    <dbReference type="CGD" id="CAL0000181892">
        <property type="gene designation" value="orf19.12875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00450C_A"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
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    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="9">
        <location>
            <begin position="103"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="8">
        <location>
            <begin position="210"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000181892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="368" mass="41724" checksum="88B9864B03AED82E" modified="2005-04-26" version="1">MLPITRRWLGNTASPAVSLLKYSRAFVRFNSTSELTELELQDIKYRKQRELSLKLTKMKNYGDAFPAHSHPGSTHYKKPVHDHLHKGRPIKELTVARSHRSSGRNNEGKITVRGRGGGHKKRARLIDFHRWNAGRQEVVRIEYDPNRSGHIALLKHLETGDLSYILAPQGLRSGDIVESFRQGIPKDFMEEMERTNNGEIDDALLSARILQRGNCLPLRMLPVGSIIHNIGLRPGDRAQLVRSAGTFGKILSKHPEKNRAVIKLSSGEQRYVILDCHATLGVVSNKEHQLISWGKAGRSRYRGFRPKVRGVAMNACDHPHGGGRGKSKSNKVSQSMWGLKKFQKTRLRPNPDQIRNRKGHLINHDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7Q8</accession>
    <name>Q5A7Q8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">HRK1</name>
        <name evidence="14" type="ordered locus">CAALFM_C300550CA</name>
        <name evidence="13" type="ordered locus">orf19.12863</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717780.1">
        <property type="nucleotide sequence ID" value="XM_712687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7Q8"/>
    <dbReference type="SMR" id="Q5A7Q8"/>
    <dbReference type="FunCoup" id="Q5A7Q8">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A7Q8"/>
    <dbReference type="GeneID" id="3640586"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300550CA"/>
    <dbReference type="CGD" id="CAL0000192730">
        <property type="gene designation" value="HRK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00550C_A"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_2_1"/>
    <dbReference type="InParanoid" id="Q5A7Q8"/>
    <dbReference type="OMA" id="EYAKKCT"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="HRK1p Protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="219"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000192730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="696" mass="78499" checksum="C12FC5AFE8A4F77D" modified="2005-04-26" version="1">MPDKHKLKLFGKNKHDKDDELSLSTSNHSHGSTRKFLGFHIGRHESGDSLTSPVMSNSSESHHHSHHPHQANSSANHRNPSPVHSNTGTATTIPSIQSPQPQASGLHRGDSDKKSSGSVVDLKKFFKTKKTSNPRKEGHSILGQYSNQLHSPPPMAQVHSPGAGSGNGSALQSREQSSTSLATLINQTSSQLLYNASHSVNSNRDPFTDDNSPLVKKYGKIGKELGSGAGGSVKLITRPSDSKTFAVKEFRAKRSTESLKDYTRKCTAEYCIGSTLRHPNIIKTIDIIHENNRYFEIMEYAPIDFFAVVMSGEMSRTEINCCLKQIIEGVAYLHKLGLAHRDLKLDNCVITNEGILKIIDFGSAVIFKYPYEQFGNNNSIQPCHGIVGSDPYLAPEVLKSPNSYNPQPVDLWSIAIIYCCMTLKRFPWKIPSQEKDNSFRLYCMYDDNFHDYYLSNECHKLLLQQRKLKNTIVRSNKRKKQLEEEKGDKPEEDEEMKDADSAPQQHHHSHDVESGKTGGSTVGKDKSNEAVTVLTDEQAEEIMAQLNEIDRKLQEFEDKKNQLKEKYEALRDADPRYQKQLAQIHEEEEKQRLKDAEHGADEKKKSHHKQIHGPYRLMRLLPHAARPVISRLLEVDPKKRATMEEILEDEWIKEIQCCTVKPVSKSTDATLDFIEDEDEVLVKGVPPHEHTIVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A853</accession>
    <name>Q5A853_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M-phase phosphoprotein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR00810WA</name>
        <name evidence="2" type="ordered locus">orf19.10785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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                <person name="Weissman J.S."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718193.1">
        <property type="nucleotide sequence ID" value="XM_713100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A9D9"/>
    <dbReference type="SMR" id="Q5A9D9"/>
    <dbReference type="FunCoup" id="Q5A9D9">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A9D9"/>
    <dbReference type="GeneID" id="3640134"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01400WA"/>
    <dbReference type="CGD" id="CAL0000198832">
        <property type="gene designation" value="LYS12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01400W_A"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A9D9"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000198832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW30901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="376" mass="40668" checksum="299F2307772A7E8A" modified="2005-04-26" version="1">MLAARSSIRRCFSTSSTTLKSLKIGLIPGDGIGREVIPAGKAVLENLPAKHDLQFEFVNLDAGFELFKKTGTALPDETVDVLKKECDGALFGAVSSPTTKVAGYSSPIVALRKKLGLYANVRPVKSVEGIGRPVDMVIVRENTEDLYIKEERVYKKEDGTKVAEAIKRITETASTRIAKMAYEIALQREAVRKGTSGKQLHEKPSVTVTHKSNVLSQSDGLFRETCRAVYDANANEYGGIEYKEQIVDSMVYRMFREPEIFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGDNFAIGEPCHGSAPDIEGKGISNPVATIRSTALMLEFMGYPEAAATIYQAVDANLAEDKIKTPDLGGNSTTQEVIDDIIRRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAJ7</accession>
    <accession>A0A1D8PRQ9</accession>
    <name>SWC4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SWC4</name>
        <name type="ordered locus">CAALFM_CR00400CA</name>
        <name type="ORF">CaO19.7492</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718649.1">
        <property type="nucleotide sequence ID" value="XM_713556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AAJ7"/>
    <dbReference type="SMR" id="Q5AAJ7"/>
    <dbReference type="FunCoup" id="Q5AAJ7">
        <property type="interactions" value="1014"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AAJ7"/>
    <dbReference type="EnsemblFungi" id="CR_00400C_A-T">
        <property type="protein sequence ID" value="CR_00400C_A-T-p1"/>
        <property type="gene ID" value="CR_00400C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639679"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR00400CA"/>
    <dbReference type="CGD" id="CAL0000199374">
        <property type="gene designation" value="SWC4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_00400C_A"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AAJ7"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000076337" description="SWR1-complex protein 4">
        <location>
            <begin position="1"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SANT">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="635" mass="74039" checksum="63D13B88267DBBF4" modified="2005-04-26" version="1">MSANDILDVLNIQRDESNQPPKKKQKSSSTPTLPDGKQLTGMARELYNLVGPNTPPINLNSNSYTANKEKMKKFKPSPWTRMPFTPKQGIELNHWVKGSKELIEQQEFEEDGTPKPYFFEKYNVQLEIPEFVDEDTYDLYMIEIKEYESKMKEERARREKERKEREKRDLEEKKKKQQQQQQKSQQNPQNQIKDDEKNQDTRNNTDKKDSEQKSEDKPTVEAKKETDEKKDDVVLKDNTNETKPVTETTKSETETTEQNNSEKTNENETNKTNDKDGEGNLTKSKDSATEDQSNNKKENDEDTESEWTYKETKHLFELCQAFELKWPIIHDRFPNPNRTAEDLKEQFYRICIKILENQKNKNQALIDSLKAYCKPRELERKQYLENLLKRTPAEIAEEESLVIEARRFEIAAKKMLMERSNLLTLLDSPQTTQNVSQYQSSQGITNLYNNLLIYDKHQKKKQMANKSNPQQEPVPPPIPLAASSSVKRDRGFQTQLQQYLSSFLKQNHHTNPAVKQEINSIQQLLMKRLTQKEEEAYGLYFHGTEKLNPGVMLRSQQKLPGLNQRQSILKSVNILLQEMDIPTGGGTSWKPIMPTRKTMAKYDELIRSVVTLLDVKKAKDKLESEIKLIKSQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAU7</accession>
    <name>Q5AAU7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">SUI2</name>
        <name evidence="12" type="ordered locus">CAALFM_C106960WA</name>
        <name evidence="11" type="ordered locus">orf19.13594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718803.1">
        <property type="nucleotide sequence ID" value="XM_713710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AAU7"/>
    <dbReference type="SMR" id="Q5AAU7"/>
    <dbReference type="FunCoup" id="Q5AAU7">
        <property type="interactions" value="1362"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AAU7"/>
    <dbReference type="GeneID" id="3639569"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106960WA"/>
    <dbReference type="CGD" id="CAL0000201409">
        <property type="gene designation" value="SUI2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06960W_A"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AAU7"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000201409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="300" mass="33882" checksum="E088A6F6B4B9071E" modified="2005-04-26" version="1">MSTTNCRFYENKYPEVDEVVMVNVQEIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIQKLIRVGKNEVAVVLRVDKEKGYIDLSKKVVSAEDIVKCDERYNKSKAVHSILRHCAEKFNIPLERLYETIGWPLSRKYGHAYDAFKISITDPSVFDSVDVPSKDVLEELKLYISRRLTPQAINIRADVDVSCFSYEGIDAIKEALKAAESVSTSQMQVKAKLVAAPLYFITVQALDKNEGVKLLEKAIEKITESIEASGGNCKVSMPPKAVSANEDAELERMLQRREAEDKDSSDEEDDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABD0</accession>
    <accession>A0A1D8PCA5</accession>
    <name>SNF7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SNF7</name>
        <name type="synonym">VPS32</name>
        <name type="ordered locus">CAALFM_C100650CA</name>
        <name type="ORF">CaO19.13461</name>
        <name type="ORF">CaO19.6040</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="1609" last="1618">
            <title>Snf7p, a component of the ESCRT-III protein complex, is an upstream member of the RIM101 pathway in Candida albicans.</title>
            <authorList>
                <person name="Kullas A.L."/>
                <person name="Li M."/>
                <person name="Davis D.A."/>
            </authorList>
            <dbReference type="PubMed" id="15590834"/>
            <dbReference type="DOI" id="10.1128/EC.3.6.1609-1618.2004"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A component of the endosomal sorting required for transport complex III (ESCRT-III).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719002.1">
        <property type="nucleotide sequence ID" value="XM_713909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABD0"/>
    <dbReference type="SMR" id="Q5ABD0"/>
    <dbReference type="BioGRID" id="1222471">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5ABD0">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABD0"/>
    <dbReference type="EnsemblFungi" id="C1_00650C_A-T">
        <property type="protein sequence ID" value="C1_00650C_A-T-p1"/>
        <property type="gene ID" value="C1_00650C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639377"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100650CA"/>
    <dbReference type="CGD" id="CAL0000187201">
        <property type="gene designation" value="SNF7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00650C_A"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ABD0"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="PRO" id="PR:Q5ABD0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071285">
        <property type="term" value="P:cellular response to lithium ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036177">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000012">
        <property type="entry name" value="Vacuolar sorting protein SNF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211437" description="Vacuolar-sorting protein SNF7">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15590834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="226" mass="25890" checksum="9570B3B1E1C0419F" modified="2005-04-26" version="1">MWGYFFGGNSQQKKDLPKKAIVELREHIQTLNKKKNHLQQQMDDQDQLARKYVSSKQTTLAKSALKRKKGYESNLLKVENQIETLETQLISIEGANLNLETMKAMKQGAKAMKQIHGEYDVDKVEDTMDEIREQVELADEISEAISRPVGNEFVDEDELDEELKELEAEAKEQEQEHRVPAQKAKPQPVSREEELPQFPSVNKKAPVVEEDEDEEALKALQAEMGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2025-04-09" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD73</accession>
    <accession>A0A1D8PGB4</accession>
    <name>SNX41_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Sorting nexin-41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SNX41</name>
        <name type="ordered locus">CAALFM_C201310WA</name>
        <name type="ORF">CaO19.1994</name>
        <name type="ORF">CaO19.9546</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Endosome and other perivacuolar punctate structures.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719444.2">
        <property type="nucleotide sequence ID" value="XM_714351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AD73"/>
    <dbReference type="STRING" id="237561.Q5AD73"/>
    <dbReference type="EnsemblFungi" id="C2_01310W_A-T">
        <property type="protein sequence ID" value="C2_01310W_A-T-p1"/>
        <property type="gene ID" value="C2_01310W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638788"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201310WA"/>
    <dbReference type="CGD" id="CAL0000183027">
        <property type="gene designation" value="orf19.9546"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01310W_A"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025790_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AD73"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="PRO" id="PR:Q5AD73"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000213826" description="Sorting nexin-41">
        <location>
            <begin position="1"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="113"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="681" mass="78368" checksum="A5A60B693146B30E" modified="2017-05-10" version="2">MSTDNLFEDIEQDNNPSFYGNPSILNDPYRPIQPPPPQQQQQQHQENESKQSHTKSPKPPLQSIHSGTSNAHPQSQPQHKHKHKHNTSLNNGYPNELVNSTIGLSNRILELLNDSQLQVDIINSEKLVNSSVIVYTIELSSPTTKIVVKRRYSEFKSLRDNLLKLFPTLIIPPIPEKHSILSYLLNTINHSHEISIIEMRKRYFKMFLDDLIFQSDYKLKNCPLLHKFFDPNYELCWYNALNEPPVSLIPDNLLLANPINPADQNGLYSLLPIVNGFDFNSHIDNLSNLKKINEDLYKLNDQVKLYELKGFEQDLEFSIPEELIQFEIKFHQTIKILTDLNKLNSKTTKNYKSMVDTLIDLGGNLNNFSLQVYQQKSGSNNELSEAIEKFGSTMDQSFLNFESFILNQLVPQWQEPVDQLILYLQNSLGLIKFYKYKIVQFKILYKLKFNKFQQLINLTNIGGVSSSGSGGGGLLASRISTDNDSNNSNNSGNNNNDGDLDTENFDHLKELNSPTINNALKNLSTKKISKKSSWYGLFGGNNQTKKFNFQLPIEEPTTATGSTEQQSQQQSAPNSPQREQQQQQSQSQSHHSHQTSIRFKLNHIEKELNKLNQLIELCNQDMHKLTEALVNTFEEFLSKIERKWLQLMITYIQNCKNMFEANLTNWKEFKESLVNETREVN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFG1</accession>
    <accession>A0A1D8PQI7</accession>
    <accession>Q3MPW3</accession>
    <name>ALB1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Ribosome biogenesis protein ALB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ALB1</name>
        <name type="ordered locus">CAALFM_C700160CA</name>
        <name type="ORF">CaJ7.0023</name>
        <name type="ORF">CaO19.7107</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000559">
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    </dbReference>
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    <keyword id="KW-0690">Ribosome biogenesis</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
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    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    <sequence length="153" mass="16842" checksum="D1E9E41B3317BFA9" modified="2005-04-26" version="1">MAGRNAINKPKIKLHAQSHAKSLGRKRAARRTTATRSSTSRYAAKGTTAPRPTDSKAVALYTGNAPQPTSTMTTQTLSNKRAKKIARNQRYLAANKLKENETAMEVDNTSEQEKQTKLDQIKKALWSVIENHQKNGYSVVSDPEGTTLGIQSF</sequence>
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        <recommendedName>
            <fullName>Metal-binding activator 1</fullName>
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        <name type="primary">MAC1</name>
        <name type="ordered locus">CAALFM_C700510WA</name>
        <name type="ORF">CaO19.7068</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="J. Biophotonics" volume="2" first="262" last="268">
            <title>From experimental setup to data analysis in transcriptomics: copper metabolism in the human pathogen Candida albicans.</title>
            <authorList>
                <person name="Hauser N.C."/>
                <person name="Dukalska M."/>
                <person name="Fellenberg K."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="19367594"/>
            <dbReference type="DOI" id="10.1002/jbio.200910004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="Microbiology" volume="150" first="2197" last="2208">
            <title>The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1.</title>
            <authorList>
                <person name="Marvin M.E."/>
                <person name="Mason R.P."/>
                <person name="Cashmore A.M."/>
            </authorList>
            <dbReference type="PubMed" id="15256562"/>
            <dbReference type="DOI" id="10.1099/mic.0.27004-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="Acta Biochim. Biophys. Sin." volume="38" first="213" last="217">
            <title>CaMac1, a Candida albicans copper ion-sensing transcription factor, promotes filamentous and invasive growth in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Huang G.H."/>
                <person name="Nie X.Y."/>
                <person name="Chen J.Y."/>
            </authorList>
            <dbReference type="PubMed" id="16518547"/>
            <dbReference type="DOI" id="10.1111/j.1745-7270.2006.00146.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2010" name="FEMS Immunol. Med. Microbiol." volume="59" first="493" last="503">
            <title>Microbial interactions and differential protein expression in Staphylococcus aureus -Candida albicans dual-species biofilms.</title>
            <authorList>
                <person name="Peters B.M."/>
                <person name="Jabra-Rizk M.A."/>
                <person name="Scheper M.A."/>
                <person name="Leid J.G."/>
                <person name="Costerton J.W."/>
                <person name="Shirtliff M.E."/>
            </authorList>
            <dbReference type="PubMed" id="20608978"/>
            <dbReference type="DOI" id="10.1111/j.1574-695X.2010.00710.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5 6">Expression is inhibited in the presence of copper. Expression is increased in polymicrobial biofilms during coinfection with S.aureus.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Results in reduced growth on copper or iron depleted media and the inability to grow on media with a non-fermentable carbon source.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720360.1">
        <property type="nucleotide sequence ID" value="XM_715267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFK0"/>
    <dbReference type="SMR" id="Q5AFK0"/>
    <dbReference type="FunCoup" id="Q5AFK0">
        <property type="interactions" value="505"/>
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    <dbReference type="STRING" id="237561.Q5AFK0"/>
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        <property type="gene ID" value="C7_00510W_A"/>
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    <dbReference type="GeneID" id="3637985"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700510WA"/>
    <dbReference type="CGD" id="CAL0000188166">
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    <dbReference type="VEuPathDB" id="FungiDB:C7_00510W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQ0T">
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    <dbReference type="HOGENOM" id="CLU_031396_0_0_1"/>
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    <dbReference type="OMA" id="CTNCETH"/>
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    <dbReference type="PHI-base" id="PHI:10336"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="CGD"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Copper_Homeo_Regul"/>
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    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000422811" description="Metal-binding activator 1">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Copper-fist" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15256562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16518547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19367594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="20608978"/>
        </source>
    </evidence>
    <sequence length="431" mass="47737" checksum="C12244998DED6E8F" modified="2005-04-26" version="1">MILIDDIKYACMECVRGHRSSSCKHHERPLLQVRSKGRPGVYANGNPNHRVAIFAEEIAKSDKPSTNGTKRCKSEPIIVLKASSKQVIDCSSGVIIGPYDETKTKPSTVEKRTPSPPIISDESFINTSACCTPKISKGKSCGCCNNKRKAVNKSKILQNYIKNKLNQKINNNETLVFMNKSHTTNNEQKEDHQLYGMVPVPSCSIPGTCCCDDACSCQGCVVHGNSKYQIPLPTSKQQVTDTTNPFENEEKFIFNSMPQTDKSDLFFNTISTSSNVPPADSSSECSCPPNACDCTNCETHGILNGFRLDDYFKDQSKLMNVLDFNFSELLGTIPEQPIPTEFMQPPSENTLLTSLSSENSFIPNQTKELSTQPPILPLDAQNVCNELDQLEPLVPSLQPCDKKATKWVNNRDTLEDVSDNRVKSCCSKKTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGD1</accession>
    <accession>A0A1D8PNF2</accession>
    <accession>Q5AGR8</accession>
    <name>APTH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C502400WA</name>
        <name type="ORF">CaO19.11723</name>
        <name type="ORF">CaO19.4248</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW29666" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="2"/>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29666.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720557.2">
        <property type="nucleotide sequence ID" value="XM_715464.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGD1"/>
    <dbReference type="SMR" id="Q5AGD1"/>
    <dbReference type="FunCoup" id="Q5AGD1">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AGD1"/>
    <dbReference type="ESTHER" id="canal-apth1">
        <property type="family name" value="LYsophospholipase_carboxylesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="3637724"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502400WA"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_3_1"/>
    <dbReference type="InParanoid" id="Q5AGD1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="PRO" id="PR:Q5AGD1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000786">
        <property type="entry name" value="Acyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <feature type="chain" id="PRO_0000229005" description="Acyl-protein thioesterase 1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="231" mass="25340" checksum="4A68674C39B8803D" modified="2006-03-21" version="2">MSVSAIRIPANGSSAKAAVIFLHGLGDSGDGWSWLPQLVSQSKLINDPINYVFPNAPKIPVTINNGFAMPAWFDIYELGNPHAKQDVTGFFKSCEVLKEFILEQHNKFNIPLEKIIIGGFSQGAAISLATLALLDTKIGGCVALSGFCPVRNEITDRYNKNPGVNFDTPIFQGHGTVDPVINYDYGKQTSELYKQLGFKNLKFNTYEGVAHSASEEELADVIKFIKNIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AHA6</accession>
    <name>Q5AHA6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C203360WA</name>
        <name evidence="13" type="ordered locus">orf19.8510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721012.1">
        <property type="nucleotide sequence ID" value="XM_715919.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AHA6"/>
    <dbReference type="SMR" id="Q5AHA6"/>
    <dbReference type="FunCoup" id="Q5AHA6">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AHA6"/>
    <dbReference type="GeneID" id="3637389"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203360WA"/>
    <dbReference type="CGD" id="CAL0000182731">
        <property type="gene designation" value="orf19.8510"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03360W_A"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_2_2_1"/>
    <dbReference type="InParanoid" id="Q5AHA6"/>
    <dbReference type="OMA" id="FHRKFPY"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000182731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW27372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="778" mass="90933" checksum="715F7BA971219D5F" modified="2005-04-26" version="1">MTGKKSTLSMSLENSQQLDDNENVLYSMSDEDEDYQHHFHQDSDEDELPKSFNSAHFSVSEDRFMKDHDLKVKAFEALHNSGSNNNNHNQVQTFSPVSPKLTSVKRRSSIIDMPQRLNNFNPAIPQNKFGQNFATDPNALPDEYPSDELIEFYQNVKKCLDFRQKYLDLSLQTPESLNPKNQPDWNIYPPPPKPTYKSKNRFNQLPRESDNDEEEEFDFSKCEIPHISDSPYYFALDDEDVYQVHDKKTDKKLVKIPNLHDYYSDLNTISKISSDGPSKSFAYKRLQYLEAKWNMYYLLNEFEETKQSKRNPHRDFYNVRKVDTHIHHSACMNQKHLLRFIKYKLKTEPDKQVIFRDGKILTLAEVFKSLNLTAYDLSIDTLDMHAHTDTFHRFDKFNLKYNPIGESRLREIFLKTDNFVDGKYLAEITQQVMEDLESSKYQMNELRISIYGRSIHEWDKLAAWVIDNKLFSHNVRWLIQVPRLYDIYKKNGNVRSFLDIMKNVFEPLFEVSLNPRSHPKLYVFLQRVVGFDSVDDESKSEKPIQSRKYPPASEWNSISNPPYSYYLYYLYANIASLNNLRLKNNMNTFVLRPHCGEAGDPEHLISAFLTSYGISHGILLRKVPFIQYLYYLDQIGLAMSPLSNNALFLTYDKNPFYNFFKKGLNVSLSTDDPLQFSYTKEPLIEEYSVAAQIYKLSGVDMCELARNSCLQSGWEANIKKHWLGKNYMKGGVEGNDIEKTNVPDIRVAFREDALQSEKNLVKYYNGLHRKSSDANSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK26</accession>
    <name>Q5AK26_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C505020CA</name>
        <name evidence="10" type="ordered locus">orf19.11477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721902.1">
        <property type="nucleotide sequence ID" value="XM_716809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK26"/>
    <dbReference type="SMR" id="Q5AK26"/>
    <dbReference type="FunCoup" id="Q5AK26">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK26"/>
    <dbReference type="GeneID" id="3636486"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505020CA"/>
    <dbReference type="CGD" id="CAL0000190950">
        <property type="gene designation" value="orf19.11477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05020C_A"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AK26"/>
    <dbReference type="OMA" id="VLFGMYS"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000190950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="396" mass="45625" checksum="ACA96B6D82C1CEE6" modified="2005-04-26" version="1">MCMWACPSVQFVTFGFPAFCRRLPFFIDRLVVRIFFQSNSTQTVPLTLINTSPTTMKTSIILFMVTLWSLVLGGLTNNELLKLVKNRKTKVLELNDENFENILNGQRDYHLIALLTSEAPNLNCVLCRELAPEYTIVANSWFQDHPNGVAEVELTEQEEKDGKKQPKNIYFFKSEFKDSKKLFSVLQLQNIPKMFYFPPTKHLGPNNYLREKVEYQFFHGDHKELLKNWLIEVTDHRFNLYIPVNKTKIAINAIGTFIVVLLLRIFSKQVIQVITSRVIWCAASIISVILFTTGYMFNQIRGTPYVMEHRDGRTEYFAPGQQSQFGVETQIMSFLYGFLSILVIVLVKRAPEIKNQSANLFLVATISSLIFVSFSLLLSIFGVKGVGFPYRFINFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AML2</accession>
    <accession>A0A1D8PLC0</accession>
    <name>CTU1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NCS6</name>
        <name evidence="1" type="synonym">CTU1</name>
        <name type="ordered locus">CAALFM_C401500WA</name>
        <name type="ORF">CaO19.12104</name>
        <name type="ORF">CaO19.4634</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722706.2">
        <property type="nucleotide sequence ID" value="XM_717613.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AML2"/>
    <dbReference type="SMR" id="Q5AML2"/>
    <dbReference type="BioGRID" id="1218528">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AML2">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AML2"/>
    <dbReference type="EnsemblFungi" id="C4_01500W_A-T">
        <property type="protein sequence ID" value="C4_01500W_A-T-p1"/>
        <property type="gene ID" value="C4_01500W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635617"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401500WA"/>
    <dbReference type="CGD" id="CAL0000179269">
        <property type="gene designation" value="orf19.12104"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01500W_A"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_3_1"/>
    <dbReference type="InParanoid" id="Q5AML2"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="PRO" id="PR:Q5AML2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103016">
        <property type="term" value="F:tRNA-uridine 2-sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000368258" description="Cytoplasmic tRNA 2-thiolation protein 1">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="395" mass="44412" checksum="BDDFD029803F1925" modified="2017-05-10" version="2">MPESTNTIINSSVKKIKLSALCELCHGRKAVMKRPKNLMKLCKECFYNIFETEIHNTIISNDLFYRGEKIAIGASGGKDSTVLASILKTLNERYDYGLNLVLLSIDEGIKGYRDDSLATVKRNQKQYDMPLEIVSYKDLYNWSMDEIVACAGIRSSCTYCGVLRRQALDRGAEKLGIKHVVTGHNADDVAETVLMNLLRGDVARLESSTNIMTTSAGSPIKRSKPFKYTYQKEIVLYAHYKKLDYFSTECTYAPEAFRGTARELLKSLESIRPSCIMDIIYSGEHLVLAPKKQKRKTVAYKNKNKNKKKSNSEQEEQEKQEQEVNPDGSISLNRNGIKKDGNTCEKCGYLSSNKICKACMLLNGLEINRAKVTIDNNSAIDGAAKLTKKLEQLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANG1</accession>
    <name>Q5ANG1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C304790WA</name>
        <name evidence="13" type="ordered locus">orf19.13363</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723154.1">
        <property type="nucleotide sequence ID" value="XM_718061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANG1"/>
    <dbReference type="FunCoup" id="Q5ANG1">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANG1"/>
    <dbReference type="GeneID" id="3635215"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304790WA"/>
    <dbReference type="CGD" id="CAL0000185323">
        <property type="gene designation" value="orf19.13363"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04790W_A"/>
    <dbReference type="eggNOG" id="KOG1814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021364_2_2_1"/>
    <dbReference type="InParanoid" id="Q5ANG1"/>
    <dbReference type="OMA" id="PRSWCQG"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="11">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="179"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000185323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="482" mass="55806" checksum="1A6F4B27AEF6783D" modified="2005-04-26" version="1">MNSGNQRTTDDLDEFSDDIRVQELQSCKYIYPDCEIDLSSLSGTVNIKVKSDNDITIRLIERTSKGTRIIATNKISNLPPIVLNFQLSADYPFVAPPEIKVTCVWLATSKTDLLTKDLYDIWKEYRDQVLFNLIDHLQDQVQNHLDVLIPAPFDIFDIDEYYKVVDFNIDAEIEEFNSQTYTCDICQKTLKGLHCTKFDSCGHVFCNNCLAEYFESCIESGDIDKVHCPDFECTKKYVDKKKKFMELETWVHNDKKVKDMLNQLLIPSIPLAMLTKILKSPSLVDRYYNLFKKSQYEWIGNLLPNRLVKCPRVGCDEVIFREDIDEKLVVCPKCKYAFCNDCRKSYHARFKLCSKINENDKYSGIPIEDLEAYPLLPPDSYDKKIMNAKYGRKRIDRAIEEYQMDQLFQQMMRERKTVVQCPGCSVATEKSEGCNKMKCSLCKTDFCFNCGSKIGNNHDHFVDPSSPCYKLLFFGMPGTEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 28</fullName>
        </recommendedName>
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        <name evidence="4" type="ordered locus">CAALFM_C304750WA</name>
        <name evidence="3" type="ordered locus">orf19.13356</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723147.1">
        <property type="nucleotide sequence ID" value="XM_718054.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C304750WA"/>
    <dbReference type="CGD" id="CAL0000185746">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
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        <location>
            <begin position="594"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000185746"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AOW28492.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68330" checksum="090FA5DC8E5D3E1C" modified="2005-04-26" version="1">MASSNNGFESINLASTISGPYQEEDTPIKRLHSIPASTSEDEDELDPEEFILNKVDKPATKDSHVSYNKFSDKHISDEQLSHLLDNHKPNLVTTTTLIDSIKESESLYNTMDSLMIKSINFPAAMYQSNDNNSQSPIEYLSNRVKLLTQELYEDSVKYGKFLQSGNNHIYQLRSRILQTFDQLSESHYSLNELYNKDMSYAETLHGSFKKWDQQRNKVLSKVKSIKSDTSKHGAKLFTLLDEVNDVDDEIKLLEAKLQQLRSKKEILNKEIEDTSSVLESRTAKYVDIFKDLENKGRSAITDFLQSNGVPEKEIDTIVRFSPVDITISSNYSSKKEPKKEIHITKESIPQNESASKPANTPSIGMQPFIIPEAEANTKTPDLQSMNHDHGPTPFEKGYAMGTQNSTALKNKMNHIMKKFLDSLPITPPSNISTMPATSRIKVDDLSNTISKRLDLDPIMVFLEHKVAALHDLAIKSSQNAALFHEFGRIWESVTKLMNSQEEKLESILNDDSNSKLVTRILNSTLEQLKSTLSALKSNPVTSGSPRDEVLISLITSEYNAIEQAVKLVSPDLRTIGELNSSGGLPPSSSKPTSQVYPVSTSDTKSTTKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANK9</accession>
    <name>Q5ANK9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C304420WA</name>
        <name evidence="8" type="ordered locus">orf19.13310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723108.1">
        <property type="nucleotide sequence ID" value="XM_718015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANK9"/>
    <dbReference type="SMR" id="Q5ANK9"/>
    <dbReference type="FunCoup" id="Q5ANK9">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANK9"/>
    <dbReference type="GeneID" id="3635180"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304420WA"/>
    <dbReference type="CGD" id="CAL0000198465">
        <property type="gene designation" value="orf19.13310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04420W_A"/>
    <dbReference type="HOGENOM" id="CLU_002173_5_1_1"/>
    <dbReference type="InParanoid" id="Q5ANK9"/>
    <dbReference type="OMA" id="MYYLFGA"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="559"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000198465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="894" mass="102101" checksum="2EA241CFF8DF9B2A" modified="2005-04-26" version="1">MSQQYPSKNSKVTPNSKHNWNFKDLLTMPTINSAKSKKTVITPNATEHDPTGVQTNESKSTSGTSDNTQSQNVSKCYCCGTILTFPNKAKKFRCSVCHTTMLLGTSPSTDSPDIPLVSYKHVKSLADECFKNANDNKGKLKSLHEIFEPLSNYLYQAFRSFEILNNSFKLRPHSKRPHHSTSNIYYSGVRDVINLLTKLPTKKPLHSALKGASEQLKRIDVYLEDSGPLAYSWVLILFEIPILSRSLVLNNPKLKLMSDVPEIKMLSYDILKRCLGILSCIDNAKTLGYFTSWLSKLDSADFIRRVDLINLYITFQLKKYFYLANNPQIKLNLSPSEDGYVDNSEAEYFQSLHLKSHIESNTDISSPCSLNLPASQFSSNPFPVKPNGKKQPKETKVKVHQYGNDWHIKSALTVLSIAYKANKLRSDPVPVSVFYNSLVDYVNIRLDFDSWQSNRRARFKGNKSSQPELWAVIEYIHGTSVNKNLYDDALFYICQYPFLISLGAKISVLEYEARRQMERKAEEAFINSLDKRVIIDVYFRIRVRRDHIVQDSLQYIKTNSDNLKKSLRVQFANEPGVDAGGLKKEWFLLLTKEIFHPQSGMFHNVDDSNFLWFNIIPVENPDMYYLFGAILGLAIYNSTILDLQFPIALYKILLKRGLDRDDYRKLYPVSYKNLINLKSMSNKEILDLDLTFEVSYSDMFGKNHTTELVTNGANIQVTKSNLEEYIDKYTGFFMKDGIAKQVDAFITGFNNVIGGNALSLFSPEEIQLLLCGNDDHRIDVDVLKSVTKYIGWRSSEDAVDSKIITWFWDHMNKMSNKERKKLLIFITGSDRVPATGIQNLPFKISLLNNGHDSHRLPIAHTCFNELALYNYSTKEKFIEKLNKAVNESAGFGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANP1</accession>
    <name>Q5ANP1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dal8p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">DAL8</name>
        <name evidence="9" type="ordered locus">CAALFM_C304160WA</name>
        <name evidence="8" type="ordered locus">orf19.13281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723075.1">
        <property type="nucleotide sequence ID" value="XM_717982.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANP1"/>
    <dbReference type="SMR" id="Q5ANP1"/>
    <dbReference type="FunCoup" id="Q5ANP1">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANP1"/>
    <dbReference type="GeneID" id="3635181"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304160WA"/>
    <dbReference type="CGD" id="CAL0000177200">
        <property type="gene designation" value="DAL8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04160W_A"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="Q5ANP1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015124">
        <property type="term" value="F:allantoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015719">
        <property type="term" value="P:allantoate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042938">
        <property type="term" value="P:dipeptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042939">
        <property type="term" value="P:tripeptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000177200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="526" mass="59377" checksum="FB6D88D65B6F395F" modified="2005-04-26" version="1">MKSEKDSEIQGINIEPIVSFTKEDLQLDKSHVLTTVISPSGKEVAITNDVDQVMQFVLDHQNTKVVLDEATDKKLLRKIDMYMLPVMCLLYCFQFMDKSSTSYASILGLREDLNMVGDMYSWIATAFYLGYLAFEFPASMLLQRFPVAKTVSVFIIVWGIILCLHSVPQYPGFIALRTILGMLESSVTPAFTIITSQWYKKEEQFLRTSWWFAFNGIGTILGSAIAYGLYQNDGNYSLPTWKLVFIVTGCLTIFLGFVVLIHIPDTPTQAWFLTDEEKLLVVERIRTNQQGFGNTHFKKNQFIEALTDYRSWLLVIYALSSNIPNGGLTNFSGILLYEDFQYSEAKSLLMQMPQGAVEIVGCVLLAWCSQFISSRLLMTVFTTSLTIMSECLLAFYPEKSGRLVGLYLPMLDPLGFICCLSCVSSNFAGHTKKITTNAMYLIAYCTGNLIGPQTFVSSQAPQYIGAKVGMIAGSSVALLSLICLYFSYVWENKKRDSRTMVDMSHIENYEFADLTDKQNPNFRYSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2025-04-09" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q9P4E8</accession>
    <accession>A0A1D8PEM2</accession>
    <accession>Q5APE2</accession>
    <name>LIP6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase 6</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LIP6</name>
        <name type="ordered locus">CAALFM_C109600CA</name>
        <name type="ORF">CaO19.12286</name>
        <name type="ORF">CaO19.4823</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Arch. Microbiol." volume="174" first="362" last="374">
            <title>Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members.</title>
            <authorList>
                <person name="Hube B."/>
                <person name="Stehr F."/>
                <person name="Bossenz M."/>
                <person name="Mazur A."/>
                <person name="Kretschmar M."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="11131027"/>
            <dbReference type="DOI" id="10.1007/s002030000218"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="4" first="401" last="408">
            <title>Expression analysis of the Candida albicans lipase gene family during experimental infections and in patient samples.</title>
            <authorList>
                <person name="Stehr F."/>
                <person name="Felk A."/>
                <person name="Gacser A."/>
                <person name="Kretschmar M."/>
                <person name="Maehnss B."/>
                <person name="Neuber K."/>
                <person name="Hube B."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="14734020"/>
            <dbReference type="DOI" id="10.1016/s1567-1356(03)00205-8"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="FEMS Microbiol. Lett." volume="244" first="359" last="365">
            <title>Differential Candida albicans lipase gene expression during alimentary tract colonization and infection.</title>
            <authorList>
                <person name="Schofield D.A."/>
                <person name="Westwater C."/>
                <person name="Warner T."/>
                <person name="Balish E."/>
            </authorList>
            <dbReference type="PubMed" id="15766791"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2005.02.015"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="FEMS Microbiol. Lett." volume="245" first="25" last="32">
            <title>DNA array analysis of Candida albicans gene expression in response to adherence to polystyrene.</title>
            <authorList>
                <person name="Marchais V."/>
                <person name="Kempf M."/>
                <person name="Licznar P."/>
                <person name="Lefrancois C."/>
                <person name="Bouchara J.P."/>
                <person name="Robert R."/>
                <person name="Cottin J."/>
            </authorList>
            <dbReference type="PubMed" id="15796975"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2005.02.014"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 9">Secreted lipase that is able to hydrolyze both the neutral triacylglycerols and the monopalmitate ester Tween 40, allowing the use of hydrolyzed products as carbon sources (PubMed:11131027). Has broad lipolytic activity, which may be important for colonization and subsequent infection, therefore contributing to the persistence and virulence in human tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5 6">Expression is induced in medium containing Tween 40 as the sole source of carbon (PubMed:11131027). Expression is up-regulated during the yeast-to-hyphal transition (PubMed:11131027). Induced during adherence to polystyrene (PubMed:15796975). Expressed during experimental infection of mice (PubMed:11131027). Expressed in host cecum and infected mucosal tissues (stomach, hard palate, esophagus and tongue) (PubMed:15766791).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AF191319">
        <property type="protein sequence ID" value="AAF79927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723509.1">
        <property type="nucleotide sequence ID" value="XM_718416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9P4E8"/>
    <dbReference type="SMR" id="Q9P4E8"/>
    <dbReference type="BioGRID" id="1217984">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9P4E8"/>
    <dbReference type="ESTHER" id="canal-LIP6">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q9P4E8">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PeptideAtlas" id="Q9P4E8"/>
    <dbReference type="EnsemblFungi" id="C1_09600C_A-T">
        <property type="protein sequence ID" value="C1_09600C_A-T-p1"/>
        <property type="gene ID" value="C1_09600C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634890"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109600CA"/>
    <dbReference type="CGD" id="CAL0000176920">
        <property type="gene designation" value="LIP6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09600C_A"/>
    <dbReference type="eggNOG" id="ENOG502S2P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="InParanoid" id="Q9P4E8"/>
    <dbReference type="OMA" id="RQYCATG"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="PRO" id="PR:Q9P4E8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000017825" description="Lipase 6">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="112"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O94091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15766791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15796975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <sequence length="463" mass="50480" checksum="21F5E66B04F73DAF" modified="2000-10-01" version="1" precursor="true">MRDLILFLSLLHTIFASLFSLKPPSQDDFYKAPAGFKAAKPGDILKTRKSPNKPSSLYAPVDVQNSWQLLVRSEDSFGNPNAFVTTIIQPKNADPSKVVSYQNWEDASNINCSPSYGSQLGAPLSTILTQLDMTFIVPPLKSGYYVVLPDYEGPKSTFGVGRQSGKATLDSIKAVLKTKDFSGINDDAKVVLWGYSGGSFASGWAAVLQPEYAPELKDNLIGAALGGFAANLTGIAESVDGEVFSGFIPLALNGIANEYPDFKKRLYEEVKPGAKADLQKGAENCLAASLISYPMYQYFTGPRRVFEKGWSLLEDKTIGKTLEDNLLIALSKEHMPQIPIFVYHGTIDKIIPIKDSIKIYKNWCDWGIGSFEFSEDKSNGHTTETVVGAPAALTWIDARFAGKPAVEGCSFTTRASNFLYPNISESAASYFKGIYQTILRSKLGSGVTSDDVSVNGLRSLYHT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2025-06-18" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q9Y7F0</accession>
    <accession>A0A1D8PKI8</accession>
    <accession>Q5A2Z4</accession>
    <name>TSA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Peroxiredoxin TSA1-A</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Thiol-specific antioxidant protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin TSA1-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TSA1</name>
        <name evidence="8" type="synonym">TSA1A</name>
        <name type="ordered locus">CAALFM_C306180CA</name>
        <name type="ORF">CaO19.7417</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-05" db="EMBL/GenBank/DDBJ databases">
            <title>Sequence of TSA-like gene in Candida albicans.</title>
            <authorList>
                <person name="Marchais V."/>
                <person name="Cottin J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="FEBS Lett." volume="544" first="228" last="235">
            <title>Identification of cell surface determinants in Candida albicans reveals Tsa1p, a protein differentially localized in the cell.</title>
            <authorList>
                <person name="Urban C."/>
                <person name="Sohn K."/>
                <person name="Lottspeich F."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="12782322"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(03)00455-1"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="57" first="1318" last="1341">
            <title>The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis in Candida albicans.</title>
            <authorList>
                <person name="Urban C."/>
                <person name="Xiong X."/>
                <person name="Sohn K."/>
                <person name="Schroppel K."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="16102003"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04771.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="Yeast" volume="22" first="907" last="918">
            <title>Characterization of thiol-specific antioxidant 1 (TSA1) of Candida albicans.</title>
            <authorList>
                <person name="Shin D.H."/>
                <person name="Jung S."/>
                <person name="Park S.J."/>
                <person name="Kim Y.J."/>
                <person name="Ahn J.M."/>
                <person name="Kim W."/>
                <person name="Choi W."/>
            </authorList>
            <dbReference type="PubMed" id="16134099"/>
            <dbReference type="DOI" id="10.1002/yea.1283"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4 5">Localizes to the cell surface in hyphally grown cells, whereas no surface but mainly nuclear localization is found in yeast-form cells.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Induced by oxidative stress.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Results in delayed hyphal development and enhanced sensitivity to cell wall-perturbing agents, yet does not impair virulence in vivo.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AF149421">
        <property type="protein sequence ID" value="AAD34017.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716082.1">
        <property type="nucleotide sequence ID" value="XM_710989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Y7F0"/>
    <dbReference type="SMR" id="Q9Y7F0"/>
    <dbReference type="BioGRID" id="1225363">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q9Y7F0">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q9Y7F0"/>
    <dbReference type="MoonDB" id="Q9Y7F0">
        <property type="type" value="Curated"/>
    </dbReference>
    <dbReference type="MoonProt" id="Q9Y7F0"/>
    <dbReference type="PeroxiBase" id="4472">
        <property type="entry name" value="Cal2CysPrx01"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_06180C_A-T">
        <property type="protein sequence ID" value="C3_06180C_A-T-p1"/>
        <property type="gene ID" value="C3_06180C_A"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_06330W_A-T">
        <property type="protein sequence ID" value="C3_06330W_A-T-p1"/>
        <property type="gene ID" value="C3_06330W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642269"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306180CA"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306330WA"/>
    <dbReference type="CGD" id="CAL0000174369">
        <property type="gene designation" value="TSA1"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000189947">
        <property type="gene designation" value="TSA1B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06180C_A"/>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06330W_A"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_1"/>
    <dbReference type="InParanoid" id="Q9Y7F0"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030985">
        <property type="term" value="F:high molecular weight kininogen binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0000353"/>
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        <property type="term" value="P:cell redox homeostasis"/>
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        <property type="term" value="P:cellular response to hydrogen peroxide"/>
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        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="term" value="P:filamentous growth"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AhpC/TSA"/>
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        <property type="entry name" value="Peroxiredoxin"/>
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        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0049">Antioxidant</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000135094" description="Peroxiredoxin TSA1-A">
        <location>
            <begin position="1"/>
            <end position="196"/>
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    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="3"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="173"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
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    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="1">
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            <position position="48"/>
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        <location>
            <begin position="45"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="disulfide bond" description="Interchain (with C-169); in linked form" evidence="1">
        <location>
            <position position="48"/>
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    </feature>
    <feature type="disulfide bond" description="Interchain (with C-48); in linked form" evidence="1">
        <location>
            <position position="169"/>
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    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P34760"/>
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    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00691"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PubMed" id="12782322"/>
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        <source>
            <dbReference type="PubMed" id="16102003"/>
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        <source>
            <dbReference type="PubMed" id="16134099"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="12782322"/>
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    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="16102003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="196" mass="21860" checksum="0BD7B6B4715DCDBB" modified="1999-11-01" version="1">MAPVVQQPAPSFKKTAVVDGVFEEVTLEQYKGKWVLLAFIPLAFTFVCPSEIIAYSEAVKKFAEKDAQVLFASTDSEYTWLAWTNVARKDGGIGKVDFPVLADTNHSLSRDYGVLIEEEGVALRGIFLIDPKGVLRQITINDLPVGRSVEESLRLLEAFQFTEKYGEVCPANWHPGDETIKPSPEASKEYFNKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCA4</accession>
    <name>A0A1D8PCA4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">RPO41</name>
        <name evidence="13" type="ordered locus">CAALFM_C100640CA</name>
        <name evidence="12" type="ordered locus">orf19.13462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713910.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PCA4"/>
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        <property type="interactions" value="269"/>
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    <dbReference type="STRING" id="237561.A0A1D8PCA4"/>
    <dbReference type="GeneID" id="3639378"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100640CA"/>
    <dbReference type="CGD" id="CAL0000185076">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00640C_A"/>
    <dbReference type="eggNOG" id="KOG1038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCA4"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
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    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="378"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000185076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW25762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1300" mass="148379" checksum="9FFDADAA9AE7F8D8" modified="2017-01-18" version="1">MLSAQRSLVRRITGVRLQVRMLHHTTKTSTATSQIDTTSAGDFKHSEVLSKVMSPLMSINHVKEAPSLKNYHNNKITYRSYLNLNPEKYDLDEEEKIVKYYSSKNDGVEVQPYAPEIQYLKNILESFSEQKYFDKIDQVLKSLSKLVNATEFTDICNKYLENILQDDSLSLQDLNSIIGQLQDKCKFKTNTRTEAIILGKMLNDSDNAQSSISEFFGNMEKQTIVEILRNMDVIGVDNLYKVFDCDSIDASVIPKELQEIYQEHKSKDHDDEIAEDILKLQENKQINPLDKKSLEELLPVDSFGLQVIRHSLLGLKPDSEAALKFADQVEKIIEDVDDEVLNQDIMSGKINYFEMYSKLKTEEQRQAFNEALNVFNLERQKQIEIRGIEGAKEKWKHDFEESQKRGDLNLSKGLNAQCYKWLQDVLPVLEKEYKLCEALINGNNSVIEKDDPNAKDRAMYAPFILKISPDKAIIITILELFKLHSTGGVVRGFRAYKAIQSVGKAIEAEYRIGLQAKKENKLFSQKHLSPQLQKLMRRTMQKGNESTPEWDDATRARIGGVLVSILMSVAKVNVRKETPQGLIEDFHPAFYHGMQFIAGNRVGVIKVHTDISNILSGTSLTESIQPQALPMLVEPKPWNSFYGGGSLYSKTPLVRVKDSPETEAYLKAANERGNLTGVFEGLNVLGNTAWTVNKKVFNVISHYWNSGEEFLSIPPVSEEPQLPQDIPGNSDPQKLLHHTTSKYQALDEYISNKSQRCDNNYRLEIARAFIGEKLFFPHNLDFRGRAYPISPHFNHLGGDLTRSLFLFWDGKELGEEGLNWLKIQLANVYGVDKESLAKRVEFVNENLEKVLESAADPFATDAWWQKAEKPWQALSVCFELAEAYKLDDPTKFVSHLPVHQDGTCNGLQHYAALGGDVEGANQVNLNPSDKPQDVYTYVAKLVETRVKADAEKGDELAIFLQDKIKRKVVKQTVMTNVYGVTFIGAIEQIRKQIIHLFPKDADHHAAARYLAVQVFASIRELFENAHFIQAWLTESAKRITKSVTLDFGESQYSEQELLSTVIWTTPLGLPCVQPYRLHKKKQLKTAVQDLNIVMPSNTSAVDSRKQQNGFPPNFIHSLDATHMLMTATKCAEFDLNFASVHDSFWTHAADVPQMNRIIREQFVKLHTTNLIELLKEEFSERYKDNYQVLPIPNNHELARKVKAIKKEWAEALNRPVQIADELYMERKRLQMLESEDPEEVEVAKNMETTISITMNYKPYEFANRQVSNSFQILVPIQFPEVPSKGEFDVNLVKQSQYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCX6</accession>
    <name>A0A1D8PCX6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol 4-phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">GGA2</name>
        <name evidence="11" type="ordered locus">CAALFM_C103130CA</name>
        <name evidence="10" type="ordered locus">orf19.10524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721504.2">
        <property type="nucleotide sequence ID" value="XM_716411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCX6"/>
    <dbReference type="SMR" id="A0A1D8PCX6"/>
    <dbReference type="FunCoup" id="A0A1D8PCX6">
        <property type="interactions" value="832"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCX6"/>
    <dbReference type="GeneID" id="3636928"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103130CA"/>
    <dbReference type="CGD" id="CAL0000181277">
        <property type="gene designation" value="GGA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03130C_A"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCX6"/>
    <dbReference type="OMA" id="PDNYEPN"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="9">
        <location>
            <begin position="184"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="8">
        <location>
            <begin position="472"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000181277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW25994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="584" mass="64757" checksum="DF4DB076E761203A" modified="2017-01-18" version="1">MSSSYSLDKINPKLLRRIYRACRPTNDEPNLALNLEICDYVNAKKGSAPRDAAIAVVKLISQRDPQTSELAIALLDNLVKNCGYPFHLQISRKEFLNELVKRFPERPPLRYTRVHRLILAQIEEWYQTICRTSKYKDDFGYIKDMHRLLSNKGYVFPEVKVEDVAVLNPNDNLKSLEELQQEESIVHSAKLQELIRRGRPQDLQEANKLMKIMAGFKDDNVKENKKQIKQDITRLTRKVEILGEMLTSIESQGGKIDDSSDEAIIELYSSVKSSQPIINKMIEQSSDHDDNEEDVNKLLALNESANNVINKFQLLKGGNVSEASKIKTGSASQELNLIDFDDAPEDVSASKEQGYTDLLSDLSNLTFSENNNATTASSSTNVNPLNLYGAGGSISLGGGSGFPTISNTPSIYQPTPSAAQGKQTSSSNFDLLADLNSPSPQLQSNTNSSSLDPFGLQFPATTPSQVTGQGEGYIRMIPINQTSNLKIEIGVKSSSANSLKGKILFSNLQTSTISNLKFLIAVPKSCKLELRPQTSDKIFGFNNHGIQQDFNIENPLSKQLKIKWKVEYQINGSANEETGVSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCZ1</accession>
    <name>A0A1D8PCZ1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C103170CA</name>
        <name evidence="3" type="ordered locus">orf19.10527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721507.2">
        <property type="nucleotide sequence ID" value="XM_716414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCZ1"/>
    <dbReference type="SMR" id="A0A1D8PCZ1"/>
    <dbReference type="FunCoup" id="A0A1D8PCZ1">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCZ1"/>
    <dbReference type="GeneID" id="3636805"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103170CA"/>
    <dbReference type="CGD" id="CAL0000195291">
        <property type="gene designation" value="orf19.10527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03170C_A"/>
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        <location>
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            <begin position="1"/>
            <end position="10"/>
        </location>
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            <begin position="11"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="655" mass="74232" checksum="28000134B7CC8C8F" modified="2017-01-18" version="1">MSSRRNKRPYKGLILKPKPIKPGSGFGTGTRSGLGTVSVTASPLASTSTTATTIISFQNGHTTYNVPNSGNVSPSTSSTSTNSLVTKKHIKKSLQNDFKLKSAVNTNNNDNEDNIPSNNGNNIFGVVGDLYDIFDANNFNEFEFLYSIYVPNKYLIKNNRKSIKHLLIHLPKIYHDSTANSSSSTTNTANNNQSTNINLSIHLFLSTIMVKFVNSWYLTKLNTANLQFLKLVYQLMVDFIKDVIARIESVDILLMIDQFGDILNTHLKQTVPTKYSDNNKYPYKFLEDYFSNQKPKLNTFDFDKSTLQVTNDYLKSNHIIFENFNSSSKNHDPSNEMLYYRLLVKNVLLASFKDRELSPSTSKITNDLIVHILSDIVIVKLIEKLSSQDFIFDKLNEILDGLLLLSSSSSTSSSFSNSVESNNVKLEPTFYQSWSGKLQKSIAQVYSGFTNFIVLSSNSKKSQLKGNENSNPATRVSGVLNWSLFSLLNTVFNLQHRKPFFYNLIISIKSLLQMNNRIAGSIDRITGEFIKTKINQSITRDKVARIINDLRVNLFYSSSDDQDPVDIDKKEQVSIDILTDKIIKVYKAYLAKYLDLSYKEETEQDLKDSIKSVLIIFQQKEENESDLQQYLDNRVNKLLIIKLLDCVIGNLYTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="319" mass="36687" checksum="D7B0D0A671469F6D" modified="2017-01-18" version="1">MSTKSANSTAVNSFNANHSNYDVFRPSFTPVLVNTFLVHLGLATKNPDDTFTFDISKHILEIAAGTGKFTRNLVDNGWTDNLAVLEPSKGMLETFNKNFPQIKNQILGSSYKIPLEDNSIDAVIIAQGFHWFADLDSLKEIYRVLKPQGKLGLIWNFDYASPSQDSSVADSEYFNAGTQYYNTLNFNLDTNEKVFEQYFDNQQWNKAATKFIYGFDVNVPQYRHGKWRQVLKDNPYFSSEEINLFALYDLTVAKDDAWKYWETRSYITEKSDDEKQRIKKDFNELVEKNLDDSSYSDKDKQLIIKPMATHAVVLQKKSS</sequence>
</entry>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000200749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="331" mass="37443" checksum="581DF8F458496F17" modified="2017-01-18" version="1">MCAYVDIYFVNSSGLTSSSRSHPGPYTDRSFGGRVSVYTSGVDVPIYQGVISSPQTSHKPTRIILSHLYFPPPTMPENLQTRLHNSLDEILKSSGYIFEVIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKEEAARKKREEEAKKKEEEAKKKAEEAKKKAEEAKKKAEEAKKAEEAAKKAEEAKKKAEEAKKAEEKARKKAETAPQKFDNFDDFIGFDINDNTNDEDMLSNMDYEDLKLDDKVPATTDNNLDMNNILENDESILDGLNMTLLDNGDHVNEEFDVDSFLNQFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDV9</accession>
    <name>A0A1D8PDV9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyk3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">CYK3</name>
        <name evidence="6" type="ordered locus">CAALFM_C106690WA</name>
        <name evidence="5" type="ordered locus">orf19.6242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="308" mass="35382" checksum="87DEFA3862FF7DE6" modified="2017-01-18" version="1" fragment="single">MTSTALPPLPFKVKTIVSWAGEEEGDLGFMENEIVQVFSIVDESWWSGKLRRNGAEGIFPKDYVTILEDKLNHSMSSLSLQDGRTTPTKQMDDHSRRSAGTTPLGNFSKLKTSQSFANDSIEYDQDHSFNQSFDDRYSKPFTPTKGNVRSSKYMSSAMNHPKNKLTYQQQEELLRKKEKEIEYFRSMQQQQNYQVKPKVNDSKRLSFQHTHHSSPDVASRLHQMDYTSPTSIKSPSYGDVPHSQNGKYQHLLNNYVATSDSTPTKTSKRATMASYEPEFLDEFDEIAKKKAQLEIELERLKQLEKLSK</sequence>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
    </protein>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
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            </authorList>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="3640737"/>
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        <property type="gene designation" value="orf19.12521"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE45"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
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    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000188735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="300" mass="32463" checksum="1B8608A6AB5B86C3" modified="2017-01-18" version="1">MAPEYANLLPVSGNWKQKITDYLTEDVPSFDFGGFVVGNTPETGSLYMKQSGVICGIPFVNEVFHQCNLQHKWIFSEGQFVSDKEIASAGGKIVVCTVKGSASNILLAERTALNLLSRASGVATQSYKTKKLADESGYTGIIAGTRKTTPGLRQLEKYAMLIGGVDTHRYDLSSMVMLKDNHITSTGSITKAVKKAKSVCGFAVKVEVEVSNEKDAEEAIEAGADVIMLDNFKGEELRQVAQSLKKKFAGTNKSFLLECSGGLTLQNLSSYLSNDIDIYSTSSIHQGVSTIDFSLKIDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE67</accession>
    <name>A0A1D8PE67_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">ADE5:7</name>
        <name evidence="20" type="ordered locus">CAALFM_C107890CA</name>
        <name evidence="19" type="ordered locus">orf19.12528</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE67"/>
    <dbReference type="SMR" id="A0A1D8PE67"/>
    <dbReference type="FunCoup" id="A0A1D8PE67">
        <property type="interactions" value="1249"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PE67"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107890CA"/>
    <dbReference type="CGD" id="CAL0000199243">
        <property type="gene designation" value="ADE5,7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07890C_A"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE67"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="116"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000199243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW26430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="802" mass="85946" checksum="E341020EFFA73F2E" modified="2017-01-18" version="1">MSLNILVIGNGGREHAIVWRLLQSPTVNHIYVAPGNGGTISESSSSKITNVPISSSPKDFNKLQQFAVENKINLVIPGPEQPLVDGIADIFYAVGIPVFGPSAKAAKMEGSKAFSKEFMDKHNIPTARFQNFTDVAKAKEHIQSIDYKIVLKADGIAAGKGVLIPETTEEALQGLNEIMVDKNFGDAGNEIVIEEFLEGDELSILTITDGYSFYNLPAAQDHKRIGDGDKGLNTGGMGAYAPAPIATQDVLKKINDQIIKPTIDGMRKDGFPMCGVLFTGIMLSPTKEPKVLEYNVRFGDPETQTVLPLLSENTDLAQVMLAAAQHRLDSVTIETKPLYSTTVVMAAGGYPEAYGKGDEITIKKPLPQDTFIFHAGTSVNDQGKIVTSGGRVIASTAIAETLRQSVDKAYVGVNEHVSFNKKYNRKDIAHRAFRDADKAASAGSGSGSGVTYADAGVSVDNGNLLVENIKAKVKSTARPGADSDIGGFGGLFDLKKAGYNTDDTLLVAATDGVGTKLRIAQIMNIHNTVGIDLVAMNVNDLVVQGAEPLIFLDYFATGKLDIEVAAQFVDGVANGCIQAGCALVGGETSEMPGMYDEGHYDTNGTAVGAVLKDKILPQINNMKSGNVLIGLKSDGIHSNGFSLVRKIIEISEYEYQSPAPWKQGSTIGEEVLVPTKIYVKQLLSSINQGLLLGLAHITGGGLVENIPRALPKHLQATVDIEQWQVPEIFKWFGKQGNVPYEDILKTFNLGIGMVLIVEKENVDKVLKNLEESGEKDAVVIGELVERKQGEPGCVVNNIDGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE97</accession>
    <name>A0A1D8PE97_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">GCV2</name>
        <name evidence="11" type="ordered locus">CAALFM_C108400CA</name>
        <name evidence="10" type="ordered locus">orf19.8015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711873.1">
        <property type="nucleotide sequence ID" value="XM_706780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE97"/>
    <dbReference type="SMR" id="A0A1D8PE97"/>
    <dbReference type="FunCoup" id="A0A1D8PE97">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PE97"/>
    <dbReference type="GeneID" id="3646505"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108400CA"/>
    <dbReference type="CGD" id="CAL0000198461">
        <property type="gene designation" value="GCV2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08400C_A"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE97"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="504"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="812"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000198461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW26478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="999" mass="109880" checksum="26879C834733128E" modified="2017-01-18" version="1">MFTKSTIRTVLRSLATKANTSSENFAKVLNPKVSFDNLDVFARRHIGPTPKEVQKMLSSLGYNDLDEFLSNVVPEHILIKRKLSVQPEKGFTESEMLDHLHKLANKNKIKKSFIGKGYAGTLLPPVIQRNLLESPEWYTSYTPYQPEISQGRLNSLLNYQTMICSLTGMAMANASLLDEGTAAGEAMALSFHNSKDKKKIYVVDANLHPQTVDVIKSRAENIGVEIVEIPLATKQGVEELSRIADKVCGALVQYPDTNGEITDFTEIGNILHSNKALFAMATDLLALTVLKPPSEFGADIALGTSQRFGVPFGYGGPHAAFFATSSKYARKIPGRIVGVSKDRLGNPALRLALQTREQHIKREKATSNICTAQALLANISANYAVYHGPQGLKNIANRVYGFTTLLANEISKKHQLVNNKWFDTLTVKLNGVSSDEILAKALNEYDINMFRVDESTVSLQLDETVQKQDLINLVNVFTGQENYSPDELPAIPQELLRSDEILTNEVFNAHHSETAMLRYLHSLQRMDLSLADSMIPLGSCTMKLNATVEMQTLSIPGFNSIHPFAPIDQAQGYKELIDEFEKDLNDITGFDGTTSMPNSGAQGEYTGLSLIREYHRSRGEHDQRNICLIPVSAHGTNPASAAMCGLKVVPVKCLSNGSIDLEDLEAKAAKHAKNLCSIMITYPSTYGLFEPGVKKAIDIVHANGGLVYLDGANMNAQVGLTSPGDLGADVCHLNIHKTFALSHGGGGPGQAPVCVKEHLKPFLPKHHFVNTPHSTSESIKAVNSAPYGSASVIPVSYSYIKMLGAQALPYVSAIAMLNANYILTKLEPHYKILFVDRDASSESGTKHCAHEFILDLREFQKIGIEAIDVAKRLQDYGFHAPTMSFPVAGTLMIEPTESENLRELDRFIDSLISIRKEIEAYQNKEPLGQVLKNAPHSLEDIVSSEDWDARGYTREQAAYPLPFLKKNKCWPTVSRLNDTYGDLNLICTCPSVEEVAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PED9</accession>
    <name>A0A1D8PED9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">FAD1</name>
        <name evidence="15" type="ordered locus">CAALFM_C108650CA</name>
        <name evidence="14" type="ordered locus">orf19.12186</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330679.1">
        <property type="nucleotide sequence ID" value="XM_019475134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PED9"/>
    <dbReference type="SMR" id="A0A1D8PED9"/>
    <dbReference type="FunCoup" id="A0A1D8PED9">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PED9"/>
    <dbReference type="GeneID" id="3634930"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108650CA"/>
    <dbReference type="CGD" id="CAL0000193566">
        <property type="gene designation" value="FAD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08650C_A"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PED9"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000193566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW26503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="283" mass="32804" checksum="E67C0E86EB19C295" modified="2017-01-18" version="1">MTNQHLRDSQIGFLQRCSECFSIVQDFLHDRVRRDIVNGVLTSDTHKNYQFDPELRESVKSKVLLSMEKLESSIDLHGLQEIAISYNGGKDCLVMLILLMATIHKKFSSSEMNNPSVNILPPDYKLDSIYINSETPFPQLVDFITSSTEYYHLNPIIIQKSLKDGFEYYLNEVNPRVKSVIVGIRHSDPYGETLQYEQMTDHNWPKFLRIHPILHWNYVDIWDFLIGCDVKYCEMYDQGYTSLGGINSTVPNPLLKLPNGKYQPAYMLKEDADNNERLGRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEI3</accession>
    <name>A0A1D8PEI3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U2 snRNP complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C108890CA</name>
        <name evidence="5" type="ordered locus">orf19.12210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723434.2">
        <property type="nucleotide sequence ID" value="XM_718341.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEI3"/>
    <dbReference type="SMR" id="A0A1D8PEI3"/>
    <dbReference type="FunCoup" id="A0A1D8PEI3">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEI3"/>
    <dbReference type="GeneID" id="3634924"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108890CA"/>
    <dbReference type="CGD" id="CAL0000176904">
        <property type="gene designation" value="orf19.12210"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08890C_A"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEI3"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
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        <location>
            <begin position="47"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000176904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="131" mass="15059" checksum="338D455284A59545" modified="2017-01-18" version="1">MPSTKRSSSTENSHKDSKKKVKLDYVNLKPSQTLYVKNLNTKINKKILLHNLYLLFSAFGDIISINLQNGFAFIIFSNLNSATLALRNLKNQDFFDKPLVLNYAVKESKVISQEKQKLQDDNDEEVMPSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEI7</accession>
    <name>A0A1D8PEI7_CANAL</name>
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        <submittedName>
            <fullName evidence="6">Lys143p</fullName>
        </submittedName>
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    <gene>
        <name evidence="5 6" type="primary">LYS143</name>
        <name evidence="6" type="ordered locus">CAALFM_C109180WA</name>
        <name evidence="5" type="ordered locus">orf19.12240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723462.2">
        <property type="nucleotide sequence ID" value="XM_718369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEI7"/>
    <dbReference type="SMR" id="A0A1D8PEI7"/>
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    <dbReference type="GeneID" id="3634894"/>
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    <dbReference type="CGD" id="CAL0000182884">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09180W_A"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
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            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
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            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
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            <end position="116"/>
        </location>
    </feature>
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            <end position="139"/>
        </location>
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        </location>
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            <begin position="181"/>
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        </location>
    </feature>
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            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEX3</accession>
    <name>A0A1D8PEX3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">RPA190</name>
        <name evidence="19" type="ordered locus">CAALFM_C110670CA</name>
        <name evidence="18" type="ordered locus">orf19.9397</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710723.2">
        <property type="nucleotide sequence ID" value="XM_705631.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEX3"/>
    <dbReference type="SMR" id="A0A1D8PEX3"/>
    <dbReference type="FunCoup" id="A0A1D8PEX3">
        <property type="interactions" value="1154"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PEX3"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:promoter-specific chromatin binding"/>
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        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
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        <property type="term" value="P:termination of RNA polymerase I transcription"/>
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        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
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        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
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        <property type="entry name" value="RNAP_I_Rpa1_C"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA polymerase II, clamp domain"/>
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    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
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    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
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    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
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        <property type="entry name" value="Rpb1_funnel_sf"/>
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    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
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    <dbReference type="Pfam" id="PF04997">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="337"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1321"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1337"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1352"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1412"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1429"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00006460"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000187313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW26694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1665" mass="186326" checksum="603221A0B83CE98A" modified="2017-01-18" version="1">MDISKPVGSEITSVDFGVLSDEEIRKLSAKQITNPIVFDNLGHPINGGLYDLSLGAFLRNVCTTCGLDEKFCPGHLGHIELPVPVYNPMFFNQLYIFLRSACLYCHKFKLNQLEVHNFECKLHLIQYGLLLECVELDNIMAKSSKSSSVIDVDGEDNDDEEGGGSVDEKSKKDLMKRRELFVKNAIESALKDGRTNHKGVVTASVSEERKATIHEFYKRLLSRPKCTNCGMYSPGFRKDGFTKIFENSLTDKQITNNRVKGLQRPDMIKKNAGNGNGNSSSTGAASDLPNIKHKGGSKYVLSTEVRNILRSLFHKEQAILQKVFHSRPYQHDPISGDLFFKQSVLVPPTRFRLPSKLGDEIHENAQNELLSNIIKTSVLIRDLNERITNMYKEKISGEDKKIIFNRLMNAFVTLQNDVNAFIDSTKNQNAPAGKIPNPGIKQALEKKEGLFRKHMMGKRVNYAARSVISPDPNLETNEIGVPPVFAKKLTYPEPVTSYNASELRQAVINGPDIWPGAIQVQNEDGSLISLIGMTLEQRKAIANQLLTPNGGNSVVGKKVYRHIKNNDVVIMNRQPTLHKASMMGHKVRVLPGEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDNQYLTPTSGSPLRGLIQDHISAGVWLTNKDTFFNRETYQQLIYGCIRPEDGHTLKNRIVTVPPAIYKPEMLWTGKQVITSVLLNIKPDNVPGVNLISKNKIKSDYWSESSTENEVIFKNGELLSGILDKSQYGASQFGIVHSLHEVYGPTVAGKALSVLGRLFTNYIMMTAFTCGMDDLRLTDEGNTWRKDILKQSVDIGRVAATEVTNLDEDTKNNNKELLRRLEEILRDDNKLGILDAITQSKVNAITSQVVSKCVPDGTMKRFPYNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPFETDARAGGYIKQRFYSGIRPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSVRDADGTLIQFLYGGDAVDTTKQSHMNQFKFCVDNYDALLTKYNPGDMTENIDTDLALSYSKKVRKSLKKQKDVPHYDQVIKYDPVLNVYNPAKYLGSVSEKFQEKLDTYVSKNPTIFAQSKEETKSTGKITEKKFRALMQLKYMRSLINPGEAVGIIASQSIGEPSTQMTLNTFHFAGHGAANVTLGIPRMREIIMTASASIKTPQMTLPILADVNDEQADAFCKSVARVVMSEFVDKVVVTETTSQDVDGSNSRSYVIGLKFYTKEEYETEYDISQEQLEDVITSKFLHALEGQIVKEVKKQKKPDYMPTVGKSAGKTDMETVSGKIKEIDNDDDDEDNEVDEDHDEEQAKQNVKQQVSYEGPDDDEIETMKKAEETSDEEMDGDNSSSSDDSDSDSDNEEDADADVDMDKPSKSELSRSAKDRQSEVIASHNMVTQFNFDDELGEWCEFKLELNGNETQKLLMVNIVEDLLRKVVVREIPHIGRCIRPEPDAKTGKRILTTEGVNFRAMWDQDDFINVNGITSNDVYAVLKTYGVEAARNTIVNEIYRVFDTYGISVSSRHLDLIADMMTREGTYLAFNRQGIDSSTSAFMKMSYETTCQFLTKAVLDGDREELESPSAKIVMGKLSNVGTGSFDVFAQMPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEX6</accession>
    <name>A0A1D8PEX6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA-(Apurinic or apyrimidinic site) lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">APN2</name>
        <name evidence="12" type="ordered locus">CAALFM_C110650WA</name>
        <name evidence="11" type="ordered locus">orf19.9394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710720.2">
        <property type="nucleotide sequence ID" value="XM_705628.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEX6"/>
    <dbReference type="SMR" id="A0A1D8PEX6"/>
    <dbReference type="FunCoup" id="A0A1D8PEX6">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEX6"/>
    <dbReference type="GeneID" id="3647674"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110650WA"/>
    <dbReference type="CGD" id="CAL0000190938">
        <property type="gene designation" value="APN2"/>
    </dbReference>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    </evidence>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
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    </evidence>
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    </evidence>
    <sequence length="66" mass="7484" checksum="6FD821D1D2955A22" modified="2017-01-18" version="1">MLSNMDYEDLKLDDKVPATTDNNSDMNNILENDESILDGLNMTLLDNGDHVNEEFDVDSFLNQFGN</sequence>
</entry>
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        <recommendedName>
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        <name evidence="7" type="ordered locus">orf19.9073</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722544.1">
        <property type="nucleotide sequence ID" value="XM_717451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGH3"/>
    <dbReference type="STRING" id="237561.A0A1D8PGH3"/>
    <dbReference type="GeneID" id="3635836"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201870CA"/>
    <dbReference type="CGD" id="CAL0000179324">
        <property type="gene designation" value="orf19.9073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01870C_A"/>
    <dbReference type="eggNOG" id="ENOG502QVYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGH3"/>
    <dbReference type="OMA" id="MINTYDY"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000179324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="451" mass="52059" checksum="FD812168AFA3E7F8" modified="2017-01-18" version="1">MVEANFLKYFYYQACCNRSNSWINLGSAIRLAQALGMHRKIINDKIENQEISIHRRRLWRSLYVCDCVSSVNLGRPLMINTYDYDDINYPVEKLLLDENDNVERIRIIAQNATSDSAVLNRSIVQNLYNGGSINIKDSNSLALQLKLWSIELPNFLQLTSDMENQLRDPTNPNNYLFVFVHIGQLYGIMALTRPFLVHVVNRKLRPNMYKPQVTDEKQLMPFCKASIKAAFLTIKLFKFYCTFNKSRKEVFTIQSATFFASILLGFTLLEQINSKKPDHHYISVIKESIRDAISIFKLFNFNATCNRWAQHLIYMMEALNRPPAIIPSSLQQTTKTSTTTTTPVLSTHPITSTNLNYQQQQQQVPPPPPPPPGSGNVKFPFQNKNNSSPSASSISSEIDRFNDELIRWNNDNTAFEQMVNFQQYFVPNDIDVLNNNYLDAFNYTNTYKYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGY1</accession>
    <name>A0A1D8PGY1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C203830WA</name>
        <name evidence="7" type="ordered locus">orf19.8458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720963.2">
        <property type="nucleotide sequence ID" value="XM_715870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGY1"/>
    <dbReference type="SMR" id="A0A1D8PGY1"/>
    <dbReference type="FunCoup" id="A0A1D8PGY1">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGY1"/>
    <dbReference type="GeneID" id="3637399"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203830WA"/>
    <dbReference type="CGD" id="CAL0000190353">
        <property type="gene designation" value="orf19.8458"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03830W_A"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGY1"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000003">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000190353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="627" mass="70726" checksum="5A1F84AF2243328B" modified="2017-01-18" version="1">MKFIGLISGGKDSFFNIYHCISQGHELVALGNLYPEISDEIDSFMFQTVGHDVIEYYSQCLDVPLYRQPILGKSTNQNLEYSVTENDEIEDLYKLLSKIVDAHPEIEGVSCGAILSHYQRTRVENVCDRLGLTSLTYLWQRNQYDLMKEMCESGLDARIIKVAAIGLTKNHLGKSISELFPALVKLNLMYEAHICGEGGEFETIVLDCPFFKKKKLVITQQDIVEHSSDVFYLRIKVELADKNVTSDYKPLESLPLLEDEFQDIADSCPKADISLSGLSIDSQRIVPKIDVTPTETTLYISNLTSMKSTIEDQTKDIFQQLDKLLGDHKLTVNDIQHITLLLSDMSNFAKVNKFYGTFFKDIYLPPSRICIETEVESIQLSCIVLKHIQPKTGIHIRSRSYWGPQNIGPYSQSIVNTQSSYKTATLSGQIPLIPATMDISNKSIAFDSALSLQHLVRVKNLVNVKQLASVVCFITDESYVPIVRSCWTDLENKGNLVIVTVRGLPRGAKVEWGGLSFEDITGIYDDFASDSEDESDDDSVSQFDNFDESCICQVGKKGEFSVVTLFTSDSDVIKSSFTFKGYRQLLCHPKDYIEIKGDYLPVNTVYDHKGKNHKYAVILKIEVHRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH02</accession>
    <name>A0A1D8PH02_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">THI20</name>
        <name evidence="4" type="ordered locus">CAALFM_C203370WA</name>
        <name evidence="3" type="ordered locus">orf19.8508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </location>
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        <location>
            <begin position="324"/>
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    </feature>
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        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08543"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000000559"/>
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    <sequence length="548" mass="60942" checksum="B48292DC57C1F248" modified="2017-01-18" version="1">MTIAGSDSSGGAGIEADLKTFSAFGVYGLTCITALTAQNTTGVRRFDKTGQKLAKEILAANLEDMLYAYTPDTAPLKVIKTGMLTNEAIAELIDQMPKINEYKVKLIVDPVMISTSGSKLSDDNGMKLCVDKLMNQAFLVTPNFPEAMALYELTDGTERKITINSMNDFIEFVISLQKSLGCKNILVKGGHIPFTKNNKPVTNYNHSNAQIRDILYESESERVTVFQSAYIDSNDNHGSGCTLASAISANVAKGLSLEDSILISIDFIHRGMISSANKLGFGNSPLNHTVTPAHVASSVIKTSNSMPTTFLNQSGEFLDYLINHPDVNNNWKNYTEHKFVKDLAENNLPFNKFLYFLKQDYHYLVNYAQVHGLAASLAPTYQQTHAQATIIAEIVEEIERHKQKLATTYNIDYETDIDLDLELSPGPACMAYCNYLLEVGKREDFLGVKVALAPCLHGYAEAAVMGQKIRKRSQNDGVVDNEQAAVYQSWLDDYTSDWYTHAESEGRKALQSLVKSMPPNDKRIEELVRIFNRVTLLEIDFWDEVLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJB5</accession>
    <name>A0A1D8PJB5_CANAL</name>
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            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
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        <name evidence="9" type="ordered locus">CAALFM_C301820WA</name>
        <name evidence="8" type="ordered locus">orf19.9233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_716648.2"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:glucan catabolic process"/>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Periplasmic beta-glucosidase"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
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        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="416"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000185978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW28223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="866" mass="97479" checksum="16080AED39B61C0F" modified="2017-01-18" version="1">MTDSFDIDNILSQLTLEEKIGLVGGIDFWHTYPISRLNIPKVRFTDGPNGIRGTRFFNGVPSACFPCGTGLAATFDHELLLTTGKLMNIEAKFKNAHVILGPTMNIQRGPLGGREFESFSEDPYLTGQIASAIIKGIQYDNEIGATVKHYVCNDLEDERSASDSLVTPRALREIYLEPFRIAIKESNPICLMTGYNKVNGEHVSQSKFFLQNILRDEWNWQGTIISDWYGTYTSKKAIENGLDLEMPGSPIFRNKQLLTSMIKSKELHIKHLDDRVKNVLKLIKFAKQSSVVVTEDGKESSENNTQETRDILRKLAQDSIVLLKNDNNLLPLKRDDVDFSSKSIAIIGPNAKIAAYSGGGSATLPAYYTTTPYNAIVEKLSSISKFDITSQLKYTIGAKAYKYLPELGPQVINPKTGKPGFSMKFYKKPKSVPNEDRELFDELDTEISDILLGDYYHKDIPSNGLYYIDFECEFTPSKTQHYEFGLTVHGTAQLFIDDKLVVDNKTKQIKGVSFLNSGTIEERGSIELHQGKTYKIIVEYGSAPTFTLKDQVGEYFGGGIRLGMNEIINDDEQEIINAVNLAKSVDLVILIIGLNKDWESESYDRPDMKLPGLQDKLIESVLDVNPNTIIVNQSGTPVEFSEWLDKSKALLHCWYGGNESGNAIADILFGNVNPNGKLSLTFPLKNNDNPTFLNFKTERGRVLYGEDIFVGYRYYEKLNRQVAFPFGFGLSYTKFEFFDLKLEKKTKDKEEEEEEEESLVVSLSVKNIGKMTGSEVIQVYVSKVESDVIRPIKELKGFTKVNLQPNETKSVNLKLIIKDSVSFFDEYANQWSVQSGQYKVHVGNSSDNIPLTESFTIEKSYFWSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJI0</accession>
    <name>A0A1D8PJI0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C302570WA</name>
        <name evidence="3" type="ordered locus">orf19.7877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719945.2">
        <property type="nucleotide sequence ID" value="XM_714852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJI0"/>
    <dbReference type="FunCoup" id="A0A1D8PJI0">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJI0"/>
    <dbReference type="GeneID" id="3638375"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302570WA"/>
    <dbReference type="CGD" id="CAL0000177043">
        <property type="gene designation" value="orf19.7877"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02570W_A"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJI0"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="552"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000177043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="743" mass="83333" checksum="5B537F03CD893863" modified="2017-01-18" version="1">MTVSFNYQNNEIVSSPTVIVSGSTSTRLYRGVVSFTNNQNKVFPPQYFEVNNGHFKAIIHVSPGERNIFQVDISDNGYINDFGFVEYGNGRGPNIVDSGSLTLSFNPLPQNKPIHLCLIRGRDSNNTYDMPKYRLQRGEVPNLENAIKKLKVAGRLMQAYTQDEMRSAGFSNRCFQFVEETIHDQTIFGYKVNSPTPHQEIKIHVLTSPKTVAELRSPELAQQNPNAKDSGGLFDHAIDLVKNCPEIYNQRNGTAVQCACMYLDSTWQNNLILTHAALGGGTNEVKMAIFGSHGLHSYPQNFPLVTPSFLDATHLTTTEVANDCNECGTSWECLNICLGAFLHEIGHSLGCPHQVDGVMLRDYVMLNRSFMTRENECLRTKSRGQIIANNGTWPKVCHWNRLDLVRFLHHDSFSLPIDRFGKTYSTTWNPDNSYQDNSAPSSYAMPSNESLVKSSAGIFLIEVITDDLARYHIEFLPKEYRGPGLQHASDLEFNNLYNALRSRKNDAKDGFKLRILSLGGDLNIDNFKDHCSKQSKQVIQSDFGLNRGHLQGFKSATLGRTDDLKMEFVGFDIKTIYKVRVYHGSALDGIKFYYKSGTGTAARSSNGGGGAPKIPKRDYLSKMFRSKLNISNQSHHKQSPQQLTNGSGGEKRTALVGKETGNYSEFIFNPNEYITFFNFRDGAWMDAVQFGTNQGRISPMFGNADGGHLSTLDAPNDDFEIVGMYFYLNQWLRGLGIIYTPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK48</accession>
    <name>A0A1D8PK48_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C305120CA</name>
        <name evidence="6" type="ordered locus">orf19.13406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330872.1">
        <property type="nucleotide sequence ID" value="XM_019475327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PK48"/>
    <dbReference type="SMR" id="A0A1D8PK48"/>
    <dbReference type="FunCoup" id="A0A1D8PK48">
        <property type="interactions" value="1023"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PK48"/>
    <dbReference type="GeneID" id="3635159"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305120CA"/>
    <dbReference type="CGD" id="CAL0000183866">
        <property type="gene designation" value="orf19.13406"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05120C_A"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PK48"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000183866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="185" mass="21807" checksum="9CD90701695FB05F" modified="2017-01-18" version="1">MADFLAPKKTNPRGIPEAPFIEKVETVIKNPETEFDNTMSMFQQRLQQYKYMEASKKQQLADLQTKIPDIEKNLDVIKHIKQRKEEGDDKMVTNYELNDTLYSKATVDVQNLNSVYLWLGAEVMLEYNLEDATELLNERLKKNQEQLQIVKEDLEFLKENITTMEVNTARLYNWDVERRKKAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK99</accession>
    <name>A0A1D8PK99_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gtt1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">GTT1</name>
        <name evidence="4" type="ordered locus">CAALFM_C305630WA</name>
        <name evidence="3" type="ordered locus">orf19.6998</name>
    </gene>
    <organism evidence="4 5">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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                <person name="Berriman M."/>
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                <person name="Schwartz K."/>
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                <person name="Martchenko M."/>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716611.1">
        <property type="nucleotide sequence ID" value="XM_711518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKJ0"/>
    <dbReference type="SMR" id="A0A1D8PKJ0"/>
    <dbReference type="FunCoup" id="A0A1D8PKJ0">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKJ0"/>
    <dbReference type="GeneID" id="3641739"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305900WA"/>
    <dbReference type="CGD" id="CAL0000174498">
        <property type="gene designation" value="orf19.7370"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05900W_A"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKJ0"/>
    <dbReference type="OMA" id="DMCIFIQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000174498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="331" mass="36924" checksum="96E8900FD61145C8" modified="2017-01-18" version="1">MIAPPPAPIVLDSQSVSGITGSISIACWIIVFAPQIYENFKRKSSEGLSLTFIVLWLAGDVFNVLGAVLQGVLPTMIILAVYYTLADIVLLWQCLAYGDGKNPDLIHLSPANPLNEDVLETAMSNEERHNRRRNQGNTTEDLESSTTSVDSSISKSSSSQFQSFLINTLMVTLVIASGVIGWYISYIKESKHHSKHPGKHNPEELIFDPLAQIFGWLCAFFYLGSRIPQIVLNYERKSCDGISFMFFLFACLGNLTYVISILSIDMSWNYLWVNSSWLAGSLGTLGLDFTIFIQFFLYNENKDDEFSEYESSSETESESLLTSSDRSYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLS0</accession>
    <name>A0A1D8PLS0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C403190WA</name>
        <name evidence="6" type="ordered locus">orf19.10186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720424.2">
        <property type="nucleotide sequence ID" value="XM_715331.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLS0"/>
    <dbReference type="SMR" id="A0A1D8PLS0"/>
    <dbReference type="STRING" id="237561.A0A1D8PLS0"/>
    <dbReference type="GeneID" id="3637838"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403190WA"/>
    <dbReference type="CGD" id="CAL0000199070">
        <property type="gene designation" value="orf19.10186"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03190W_A"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLS0"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008637">
        <property type="term" value="P:apoptotic mitochondrial changes"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110076">
        <property type="term" value="P:negative regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000022">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="109"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000199070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="447" mass="50503" checksum="AF4D2F50FCC68579" modified="2017-01-18" version="1">MTDLTKQPLKGYDNLSTPTLFNDRNLHPIARSFTTNILIVGGAYSGLSALRSLQLHLAEQIQRFKQEQPSTPIKKLSLTIVEPRNGLLNILGIPKSIVDSAFAKTQFIPFKDLNNCKFANIFSDTPDEYDISWFGDDNEWLDINYVHGRVTYLDQHKAQYTLGSPVSEKAIIEFDYVILATGRDRNWPTTPLATTYGQYMLEMDNARQEIANADTISVIGAGAVGIEFAGDIKTEFPHKTVNLIHPHECFPQEPLSNEFKRLTQDSLERAGVNVYLNTRIRAESIEKRHGDLTTTNNKTIHSNLNIWSCSKHNNIGFLSQHIYENYVTSNKNISINQYLQLYNAETNTTIENFFVLGDLVELPIIKSAGWAMYMGRQVANNLSNLIFNGIFVESFPDLNAIPYGMVIVGGNNEIISELAGEVEVDNEHYKQEYEDYCIGKIRATIDM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLT8</accession>
    <name>MOH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-Apoptotic protein MOH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein yippee-like MOH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MOH1</name>
        <name type="ordered locus">CAALFM_C403430WA</name>
        <name type="ordered locus">orf19.10876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2025" name="Fungal Biol." volume="129" first="101642" last="101642">
            <title>Moh1 coordinates ROS-dependent apoptosis in genotoxic stress response of Candida albicans.</title>
            <authorList>
                <person name="Wang J."/>
                <person name="Gao W."/>
                <person name="Tang X."/>
                <person name="Feng J."/>
            </authorList>
            <dbReference type="PubMed" id="40915675"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2025.101642"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Pro-Apoptotic protein that acts as a critical regulator of ROS-dependent apoptosis during genotoxic stress response (PubMed:40915675). Negatively regulates biofilm formation (PubMed:40915675). Dispensable for hyphal morphogenesis and virulence (PubMed:40915675).</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is significantly up-regulated under genotoxic stress and in DNA repair-deficient backgrounds when RAD52 is deleted.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Enhances resistance to genotoxic agents such as methyl methanesulfonate (MMS), hydroxyurea (HU), and UV irradiation, improving cellular survival and reducing apoptosis (PubMed:40915675). Exhibits reduced intracellular reactive oxygen species (ROS) (PubMed:40915675). Leads to dysregulation of DNA repair (SPO11, RFC52) and apoptosis (Orf19.2175) genes (PubMed:40915675). Does not affect hyphal morphogenesis nor virulence in a Galleria mellonella model (PubMed:40915675).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711589.1">
        <property type="nucleotide sequence ID" value="XM_706497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLT8"/>
    <dbReference type="SMR" id="A0A1D8PLT8"/>
    <dbReference type="STRING" id="237561.A0A1D8PLT8"/>
    <dbReference type="EnsemblFungi" id="C4_03430W_A-T">
        <property type="protein sequence ID" value="C4_03430W_A-T-p1"/>
        <property type="gene ID" value="C4_03430W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646809"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403430WA"/>
    <dbReference type="CGD" id="CAL0000187831">
        <property type="gene designation" value="MOH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03430W_A"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLT8"/>
    <dbReference type="OMA" id="NIQIITC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0053">Apoptosis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463496" description="Pro-Apoptotic protein MOH1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Yippee" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="40915675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="40915675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="263" mass="29885" checksum="0BC30E459D6DCB60" modified="2017-01-18" version="1">MGLKCTNYFENSKYESPNIQIITCKGCSSHLCLSDLILSDNFNGASGPAYLVEDLINIEFNLQSEETPMKTGVYKINKVKCHQCKNQLGWYYKKSYSFAETYKEGKFVIERKFINFTDNLTTTQLLTERALQNKFKRRYSNNSTNSSTSNTSNSSTISNNSISDLEIDESGSPQHESFLTKEKFKLLNRRRSSGTNGNINATLLNHLRIPYHSIRNEGRNGAEEEEDDDDDDEDHHEHVNIVSGTTTTSRPSNIDDDDIFVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLU5</accession>
    <name>A0A1D8PLU5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Csh3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">CSH3</name>
        <name evidence="4" type="ordered locus">CAALFM_C403390WA</name>
        <name evidence="3" type="ordered locus">orf19.10874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711586.2">
        <property type="nucleotide sequence ID" value="XM_706494.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLU5"/>
    <dbReference type="FunCoup" id="A0A1D8PLU5">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PLU5"/>
    <dbReference type="GeneID" id="3646798"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403390WA"/>
    <dbReference type="CGD" id="CAL0000198586">
        <property type="gene designation" value="CSH3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03390W_A"/>
    <dbReference type="eggNOG" id="ENOG502RXJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLU5"/>
    <dbReference type="OMA" id="ANMLFDG"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043090">
        <property type="term" value="P:amino acid import"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036187">
        <property type="term" value="P:cell growth mode switching, budding to filamentous"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036168">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000198586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <name>FAD</name>
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        </cofactor>
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        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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    </dbReference>
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    <keyword evidence="8" id="KW-0274">FAD</keyword>
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    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="19"/>
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            <begin position="443"/>
            <end position="561"/>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        <source>
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    </evidence>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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            <dbReference type="PubMed" id="17419877"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="7 8" key="3">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <comment type="subcellular location">
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    <dbReference type="GeneID" id="3642821"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406140CA"/>
    <dbReference type="CGD" id="CAL0000183857">
        <property type="gene designation" value="orf19.10440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06140C_A"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMH0"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000183857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51902" checksum="472617E6F7DE22A8" modified="2017-01-18" version="1">MISRNVQRVFVLLSCTFLGLICGTLYLYSSYSPQLANQLHYSASDSSIIALCGTIGVAIAGPISGAVVDRKGYTVSLLIGGILIISSYIGLKRQFDYAWSNVQFSSFTIFLVGVGSTFINSACLKCCAVSFPSIRGVATSLPLALYGLSALFYSVIASVFYPGDTSNFLGFLVMSIIFIYLICFPSVYIADCEHKLKSASTFHKPSVTVNSTHHHPSNTDSQSISSLFTDVKFWLLFLITGTLAAMGQMYIYSVGYMVKALVTKALPAEMNVNIIIQQDQQFQVGLISIANFIGRIVSGISGDIITQSFHKPRESLLFIPAIGMGICQLLAFNIESYTELPSNSFLIGFFYGFTFCISPIIVGDAFGMENFSFNWGIVSMSPIVPSFYFTKLFGQIYDSNSVTIQDLNDANSNTFVCTLGKLCYNSIFKLTLALSISAIIAVVVLNFREFISKRRKITSLPLASPTQGIVNEKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMN4</accession>
    <name>A0A1D8PMN4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Syntaxin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C406810CA</name>
        <name evidence="3" type="ordered locus">orf19.10640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715437.2">
        <property type="nucleotide sequence ID" value="XM_710344.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMN4"/>
    <dbReference type="SMR" id="A0A1D8PMN4"/>
    <dbReference type="FunCoup" id="A0A1D8PMN4">
        <property type="interactions" value="1254"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMN4"/>
    <dbReference type="GeneID" id="3642916"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406810CA"/>
    <dbReference type="CGD" id="CAL0000201727">
        <property type="gene designation" value="orf19.10640"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06810C_A"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMN4"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000201727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="640" mass="72255" checksum="C2DC5A7569ADF26F" modified="2017-01-18" version="1">MSLDVSLRDRQISILQRMLHLNKEGSADLTLASKSEEIIWKVLVLDAKSRSVLSSVLRVNDLLKCGITVHSLINSKRANLPDVPVIYFVEPTIENILYIIEDLNQDRYDSFYINFTSSINRELLEEFAKKVSISGKSQKIKQVFDQYLDYIVTEPNLFSLNLPEIFTQFNSSNTDEEKIHKLVDVIANGLLSTIVSMDIIPVIRAQQNGPAEFVAQQLDLKLREYLSNTRGSTVATASIQQRPVLILLDRNFDLASMFSHSWIYQCMVSDVFQLQRNTIKITKHAAKDGEKDSTKNYDVDPKDFFWNKYSQLPFPDAVESADAELNAYKNDAKEVTAKTGISSLDDIDPNANATANIQQAVEKLPELTARKATLDMHMDILSSLINELQAKNLDKYFEIEQNATDPKVLKEFLELLVVDSERDSSLDKLRTFIILTLLVDLTPEYIEKVKSIFKEKYPQVDLSSFNYILKFKEHSKLANLSTLNETSNNFTNQASQMNSSALLSGLSSKLYGLTEGKISEGLTSIATRIKSFIPEKKLLPITTIVEAIMDPINASQQSVQLTDEYVYLDPKSRGGHSKPPKRQSYQESLVFVVGGGNYLEYQNLQEWANDPNKAHRKVIYGSTEITSASEFLEECSVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMP9</accession>
    <name>A0A1D8PMP9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_C406850CA</name>
        <name evidence="13" type="ordered locus">orf19.10636</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715433.2">
        <property type="nucleotide sequence ID" value="XM_710340.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMP9"/>
    <dbReference type="SMR" id="A0A1D8PMP9"/>
    <dbReference type="FunCoup" id="A0A1D8PMP9">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMP9"/>
    <dbReference type="GeneID" id="3642912"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406850CA"/>
    <dbReference type="CGD" id="CAL0000175273">
        <property type="gene designation" value="orf19.10636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06850C_A"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMP9"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000175273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="371" mass="41211" checksum="3E151AFF1DA18910" modified="2017-01-18" version="1">MASICAAPHCGKETESALKCPVCLKEGVSSVFCNQICFRSSWAIHKGIHKAEDGSEDYNPFPNFEFTGELRPHYPLTPRRAVPKHIKLPDYAQDGKPISEIKNDRIGKIPVLTPKEIEKIRKVTKIAREVLDITASHVKPGITTDELDAILHKECVKRNAYPSPLNYYNFPKSLCTSINEVICHGIPDKTKLQDGDIINLDVTIYYLGFHADLNETYYVGDKAKCNPELVNLVETTRECLDLAIKHVKPGIAFRELGNIIEKHASENNCSVVRTYCGHGCGALFHCQPNIPHYAKNKAIGIAKPGQVFTIEPMLNVGTYKDLSWPDKWTAVTQDGKCSAQFEHMLLVTEDGCEVLSARTETSPGGPGPRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNA8</accession>
    <name>A0A1D8PNA8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">RPN8</name>
        <name evidence="8" type="ordered locus">CAALFM_C502030WA</name>
        <name evidence="7" type="ordered locus">orf19.10677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714586.2">
        <property type="nucleotide sequence ID" value="XM_709493.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNA8"/>
    <dbReference type="SMR" id="A0A1D8PNA8"/>
    <dbReference type="FunCoup" id="A0A1D8PNA8">
        <property type="interactions" value="1125"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNA8"/>
    <dbReference type="GeneID" id="3643770"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502030WA"/>
    <dbReference type="CGD" id="CAL0000190180">
        <property type="gene designation" value="RPN8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02030W_A"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNA8"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
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    </evidence>
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    </evidence>
    <sequence length="330" mass="36727" checksum="1ECA896B0503B654" modified="2017-01-18" version="1">MSTTATSTNELALLDKSVVVSPLVLLSVVDHYNRVAKDSKKRVVGVILGDNSTDTIKVTNSYAIPFEEDEKNPGVWFLDHNFIDSMGEMFKKINAKEKLIGWYHSGPKLKPSDLKINEVFRRYTDNPLLLIVDVQPREVGIPTDAYFAVDDIKNDGSAAEKTFIHVPSLIEAEEAEEIGVEHLLRDIRDQAAGNLSLRVSETHQSLLGLHQKLGEIANYLDKVYQKKLPMNHTILGKLQNVFNLLPNLMQQSGSDLDGGSDSSHALATAFTVKTNDELMIIYISTLVRAIIAFHDLIENKLENKKLNENKAQASVAESSLNSEKKDSIED</sequence>
</entry>
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                <person name="Federspiel N.A."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000179424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="860" mass="98799" checksum="4A74F7F051EFF660" modified="2017-01-18" version="1">MSESPSQPPQKKHKPTTTGPSSSSSSKLTRAISACKRCRTKKIKCDQKFPQCGKCEVNGVECIGVDSVTGREIPRSYIVHLEERVKFLEEKLRLQDRSGFVDEGVSSTPPGSSTIKKKSNEISINEPLIKNESPLINTKLDSIAFSKIMSTAVRVQNRLSDPNIKPGNGNVNLGHNSTTTNENGIDINNDISRAVLPPKSTAMQFLRVFFHQCNSQLPLFHREEFLRDYFIPIYGEFDESISLASNNTKINKSFFNSSSSDGDKTPCWFDVYKSKIQQLLTENTQNDIQTIANNIIPPLKYRKPLYFLNLVFAVATSANHLRYPIHISESFRLAAMRFSQDVDNSIDPLEHLQGILLYAGYSIMRPTNPGVWYIMGEALRICVDLDLQNELKTKSKQNFNIDNFTRDKRRRIFWCCYSIDRQICFYLDRPFGIPDESINTPYPSSLDDSKIIPNDNSTDYYYYKNHHHHHHHDDDDDDNEDDINFSYKNVSLLFFKIRKIQSQVTKILYTNAEIPREYKDLNHWKQSILIQLTQWKQELQSKLISKQLNCDFNEIFFQLNYHHTLLYIHGLSPKNYKLSLIDYENLTNSSIQVINCYTELLKTKSINYTWAGVHNLFMAGTSYLYALYNSKEIRLINSIDQVQKITNDCLLVLQSLIGRCDAANYCCEIFHNLTMIIINLKYAPKDKKHLTELKPANSIPSSSFSSSSSFSSSSSTSSSKISRESLYRINNGNVHSNLFHLVTELDHLNPLTKTKTINNNNSDHFDITNDEKQDHDSTIITDDLSSPPIDSSLLPLNQQTILQWNDEELQNFLNELNQSNQSNQSSPNNNSSIRDEKKTFELIHDMPNEIIWDEFFANKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP87</accession>
    <name>A0A1D8PP87_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cta24p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">CTA24</name>
        <name evidence="3" type="ordered locus">CAALFM_C505500CA</name>
        <name evidence="2" type="ordered locus">orf19.11536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721962.2">
        <property type="nucleotide sequence ID" value="XM_716869.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PP87"/>
    <dbReference type="SMR" id="A0A1D8PP87"/>
    <dbReference type="STRING" id="237561.A0A1D8PP87"/>
    <dbReference type="GeneID" id="3636475"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505500CA"/>
    <dbReference type="CGD" id="CAL0000175094">
        <property type="gene designation" value="CTA24"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05500C_A"/>
    <dbReference type="eggNOG" id="ENOG502QPJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PP87"/>
    <dbReference type="OrthoDB" id="4092858at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:inositol hexakisphosphate binding"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="Mediator_Med2_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11214">
        <property type="entry name" value="Med2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000175094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="252" mass="28690" checksum="04C258FE3DBF318C" modified="2017-01-18" version="1">MPENLQTRLHNSLDEILKSSGYIFEIIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKHDELKVKEEAARKKREEEAKKKAEEAKKAEEIKKAEEAKKVEEAKKAEEAKKAEEAKKAEEAKKAEEAAKKAEEAAPQKFDNFDDFIGFDINDNTNDEDILSNMDYEDLKLDDKVPATTDNNLDMNNILENDESILDGLNMTLLDNGDHVNEEFDVDSFLNQFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPB0</accession>
    <name>A0A1D8PPB0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">STV1</name>
        <name evidence="11" type="ordered locus">CAALFM_C600300CA</name>
        <name evidence="10" type="ordered locus">orf19.8781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712308.1">
        <property type="nucleotide sequence ID" value="XM_707215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPB0"/>
    <dbReference type="SMR" id="A0A1D8PPB0"/>
    <dbReference type="STRING" id="237561.A0A1D8PPB0"/>
    <dbReference type="GeneID" id="3646070"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600300CA"/>
    <dbReference type="CGD" id="CAL0000189983">
        <property type="gene designation" value="STV1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00300C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPB0"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF59">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A, GOLGI ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000189983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="943" mass="107686" checksum="D8881C6EC6BB258C" modified="2017-01-18" version="1">MSPIRLSENSVLSSNNESNEAIFRSAPMTLVQFYVTIELARDMVGVLGKLGNVQFRDLNSKLTPFQRTFITELRSIDGLVSQLDFLHSIMIKQNTIKSDLYVNLHADMKPLPTSSEIDNIKTRLSEFYERIKHLDQSYNNLDRKRLKFIENRCVLNSLNEFHRSNLVGGGYDDEHTEDADYDDNAALLNEQRNHSLEIGYEAHNLDDISFNSLAGTIARDKVPILRNILWRVLRGNLYFHDIALDDEFPATESSMDLVHKNVFIIFIHGDFLRTRVRKIIQSLDGILFDNATGGSVARNETLTEINGKIEDLNNVVQTTKDQLVTELMIFQELYPDYCYIVQREKLIYETLNKFDEDSTRRCLVGEGWIPTNDFDKIRLALRNLIRQKTRRDGSDRDSNESVNISESIATETSLFAIDDSDHELTGFEIEDEDEVGSLIAVVNELATNRTPPTFHKTNKFTAAFQSIIDAYGIATYQEVNPGLATIITFPFMFSIMFGDLGHGFIVFLMAIYLILNEVRFGAMRNRDEIFDMAFTGRYIILLMGVFSMYTGLIYNDIFSKSMAIFSSGWKYVIPENYDATKGATLVAEKIAGKVYPFGLDWAWHGTENNLLFTNSYKMKLSVLMGYTHMNYSLMFSLVNYLFFKSRVDIIGNFIPGFLFMQSIFGYLALTIVYKWSVDWFGSNRQPPGLLNMLINMFLSPGTIEEPLYAGQKYIQVFLVLVAAVCVPWLLIYKPLVLKKQNDRAIQLGYSDLRSQRQHSLQLHEEEQALAMHDQGLNRDPPDDSFELLRGSDEEEQEFRFPNDVEPMFPSAGGHGGDDEDGFNFGDIVIHQVIHTIEFCLNCVSHTASYLRLWALSLAHAQLSTVLWSMTIQNAFGKTGTVGVIMTVVLFAMWFSLTVCILVFMEGTSAMLHSLRLHWVEAMSKFFQGEGYAYEPFTFKSIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPF9</accession>
    <name>A0A1D8PPF9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">SEC8</name>
        <name evidence="8" type="ordered locus">CAALFM_C600780WA</name>
        <name evidence="7" type="ordered locus">orf19.11131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711320.2">
        <property type="nucleotide sequence ID" value="XM_706228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPF9"/>
    <dbReference type="SMR" id="A0A1D8PPF9"/>
    <dbReference type="FunCoup" id="A0A1D8PPF9">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPF9"/>
    <dbReference type="GeneID" id="3647078"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600780WA"/>
    <dbReference type="CGD" id="CAL0000180162">
        <property type="gene designation" value="SEC8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00780W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPF9"/>
    <dbReference type="OMA" id="HMEVRCR"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="6">
        <location>
            <begin position="319"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000180162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126857" checksum="DB9704FCF0188CB5" modified="2017-01-18" version="1">MSIRRYSGNSPRINDYDSRTVDESLYSLKEVYNTIKYDWPQMLREDANPIEMAVALLDDTSVGLAHRLQEFNMLKESSEQALRSVVNEHYDLFNKSMGSYNTLLSTMKNSQEDSLEIKNFLEYSNKEVHDRSAVLGELSSASAKYSEMIEVLDAMAEMNEIPGKIDQLVIDKKIHEVYDVISEGYKTAEKYNLWSLPAMNGIKTYLEEQSNKLFDMIIDELQNEIYLKYNRNPQEGAIAWQNIIHSSNPQLTSFVTLLDSKNLEQFIFNSANLDISEVVDFLTSPVKNFIVNQLPDLHAHNSKNDGVIDYKILLDSTSNPNTESFYYIYMLLLTASKLNRLNQAVEVLLDTNQSELHGLINRTTEAVKSRNGHALSKLSKMQHLDHGSLFDVIVHGSFSDSAVVLLQDLFGSIFIRCLATFQRHKVITQIVTLLQEGKAPSTPKAVAESTPTFDSPQMGRPDTFHARNLFTIWKTIQKELKALMLNYIYDDHNYKLHSLADTTGATNRNKISNALGKKELFKFEDVTYNPSNKTTKEILDVLADVFPGYSISDDNNNGAIIETATPYVKHESFNATVEVLVPKNLFNMRIILEFFLIFIDGSQRIFFDFEDEKTRGVHARTSFHFFEDFMKISFLSYLRNTIEFNFGEQVGGAYSMKIEQAMPVNSGLKLDLISLSQDSNFKILGNAVSNVESNLIIYENAYNFKKMFLELCLILNTSLSYRENFSGAVLKTLENFSNEYNKLYQELLSTGEGTNIVRPPSRVSKWMKIPVLTEISGKILQRGVQGETANELQELIESESKVVLHDETVTHQEDLLDHEAYAQIVYLLLTTTWILSWLPLVKKESNYSIYDDEQNKTIKVSTVDKLRYNWSFLENGRQAINFTPDGTDIVQYNIYLALNSEKIGEFNNIIHNFESIRDKTLLALRYELRCKAVYFVTMSFKHVDWCPVTEPGDADHFIVNLNQEIFAMDNKLSKTVSDIERESIFLGFSQFLNDLIITRSKAVRKINSNGIKRILLNISTVQQMLRNLSSNPETIDFTKASEYFEMFTMNEFNLLKFIKSKRDNYTKDAYHTLARLIYSEKLADGNGSSFNKGKYNDLIKKIDGIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPU7</accession>
    <name>A0A1D8PPU7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deubiquitination module subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C602310WA</name>
        <name evidence="3" type="ordered locus">orf19.10977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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        </source>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045142">
        <property type="term" value="F:triplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042762">
        <property type="term" value="P:regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060260">
        <property type="term" value="P:regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001015">
        <property type="term" value="P:snoRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="751"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000184138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123814" checksum="562D4F84102B8AAE" modified="2017-01-18" version="1">MQEPTDISYYIGKESAESLNLLDVPVGGGQIVSIDLRNELSDDPSELIQFLTDQQTEKQYWIIAASGYAKLGKLKESLEFINAALKLDYFNENDKKSFESFIIWLLVKNVYLGIDKDNNLNLAKKEISKLNFKIQTDSETSTSISTSNLLSSAILYLYESKDDDAIDIFDRILRIDPNNCFALLGKAQSVLNKTKNYSHALKLYQQVLILNPLMKPDPRLGIGLCFWFLKDDKMAIQAWERSLQLDPTNVKSRIFLNLAKFHTTFTNSLSDEEFLDNYKNCLQELSKLKSLNANDTTVTLALCSYLFSKGDYNTVIKIVEKIVKGITGSDNLKKFSTFSRITKYESNALSQCATWLARIEFARGNFTQSSKYFQEAIKLNETNIVAKLGLGQSQYNRGSIEEASLTFESILRSNVKCLEVNYSLGVLYSKQNSRSKKELAIQVLERYIRLSNNRGLSSNEEEFVLNKEPVALNAYLILSQLYEAKGDMTQALTYLNKAVEARRQVEKDVPLEVYNNIGVFQFTKQNYDSALENFTTALGKLDGRDFKSPDGDTLVDLPQDLRTSLTYNLARTKEISNQKDALETYEQLLTECPHYFSAKLRILFLNCITEGITKEEIRDEIESLLDLNASDLEVRSFYGWFIKNFGKKLHMPSDADTKLQKDTLVEFDSHDCYALISLANIYCIMARDTKGADEKKKKYYLRAIELFTKVLSLDSKNVYAAQGLAITYIENKQLNKGLDILRKIRDSLNDISVYLNLGHVLCDLKQFGKAIENYELALTRYTDGKDAKILSFLGRVWYLRGNAESSLPYLKKALGYAQAALDAARSTSTAALAFNISFVQFQIADFITKQPVNERNIEDIESAIEGLNKAIDILTQLASDEEKHPPYPREELRGRANLGTSTLLSRLANALEETKENNAEIEEKIQKAKQIRLDEEQARLKEEEERLNKLKEKELEMSKQRMLLQEQAQKWAEENSASVGVSDNEEDDDKLFDEESAQKENKRKKGGSSKGKKGKGRKKKGNIIDDSEEEPEKNITDDSEDEANGNSNGKRKAADDAGGKKKKKPLSSEFIQDSEEELEDDDLFGDNDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR11</accession>
    <name>A0A1D8PR11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C702100WA</name>
        <name evidence="3" type="ordered locus">orf19.13860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331034.1">
        <property type="nucleotide sequence ID" value="XM_019475489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR11"/>
    <dbReference type="SMR" id="A0A1D8PR11"/>
    <dbReference type="STRING" id="237561.A0A1D8PR11"/>
    <dbReference type="GeneID" id="3637023"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702100WA"/>
    <dbReference type="CGD" id="CAL0000194232">
        <property type="gene designation" value="orf19.13860"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02100W_A"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PR11"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000194232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="387" mass="43099" checksum="E967F0C1DE8A84DC" modified="2017-01-18" version="1">MSSTDKKTPAPDYSIKNSDVVSKYKTAGEISNKVIAQVKALAVDGATTYDLCTKGDELMNEELSKIYNSKKTKNTPKGIAFPTCVNPNHIPAHLAPVNAEDEANITLHNGDVVNIMLGIQIDGFPSIVAETLVIGASKESPVTDKRADLLNAAWTASEAALRTFKPSNRNWDVTNVVSKVAKEYETVPLENMLSHNQERLVLYGPKEIILNPSKQNKNSMETHRFEENEVYGLDILISTSADGKTKPSNFRTSMYKLTGETYALKMKMSHKILTEFKAKCNNQPFPYNIRNLEDPKKSRGGLAEPVNHKILLPYDVVVEKEGEYVAQFFTTFGITKHGIVKYTSPEFDADFYKSDKSIKDEEILKTLEEPLNTKPVKKKGTTATEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR50</accession>
    <name>A0A1D8PR50_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">LSM4</name>
        <name evidence="13" type="ordered locus">CAALFM_C702510WA</name>
        <name evidence="12" type="ordered locus">orf19.6458.1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
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        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
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    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
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        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
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        <property type="component" value="Chromosome 7"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
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        <property type="term" value="P:filamentous growth of a unicellular organism"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:tRNA processing"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lsm4"/>
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        <property type="entry name" value="LSm4/Sm_D1/D3"/>
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        <property type="entry name" value="LSM_dom_sf"/>
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        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
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    </dbReference>
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    <dbReference type="PROSITE" id="PS52002">
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    <feature type="domain" description="Sm" evidence="11">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
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            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="130" mass="14706" checksum="1C68148639C6DBD1" modified="2017-01-18" version="1">MLPLYLLTAAKNKPILIELKSGETYNGNLTNCDSWMNLTLHNVIQTDSRGEKFMKIPEIYIRGIHIKYLRIPDDIMGYAKEQSMINMENRNRYQKRRGTSSGGGGGGGGGSGDSRRFNNRQSHGHNYGRR</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
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        <name evidence="4" type="ordered locus">orf19.1336.2</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C703380WA"/>
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        <property type="gene designation" value="orf19.1336.2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000200024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="99" mass="11905" checksum="7DC21CA8EB9A31C9" modified="2017-01-18" version="1">MHPQLDKNRFNTCDKLMDALEECHRQEFLKQCLGMCNFEKEQLIQCLHYQRVEDSKLRILETREKRKNWELKKKQAEEEAYGKNGYLKKVLEAEAASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRH3</accession>
    <name>A0A1D8PRH3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ume1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">UME1</name>
        <name evidence="10" type="ordered locus">CAALFM_C703960CA</name>
        <name evidence="9" type="ordered locus">orf19.7185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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        <scope>GENOME REANNOTATION</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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                <person name="Federspiel N.A."/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="3 4" key="2">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000178792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">CDC60</name>
        <name evidence="15" type="ordered locus">CAALFM_CR01690CA</name>
        <name evidence="14" type="ordered locus">orf19.10092</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718229.2">
        <property type="nucleotide sequence ID" value="XM_713136.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS12"/>
    <dbReference type="SMR" id="A0A1D8PS12"/>
    <dbReference type="FunCoup" id="A0A1D8PS12">
        <property type="interactions" value="1242"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS12"/>
    <dbReference type="BindingDB" id="A0A1D8PS12"/>
    <dbReference type="GeneID" id="3640128"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01690CA"/>
    <dbReference type="CGD" id="CAL0000201312">
        <property type="gene designation" value="CDC60"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01690C_A"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS12"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="200"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="810"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="958"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
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            <dbReference type="CGD" id="CAL0000201312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125411" checksum="B18DF3D7A8281787" modified="2017-01-18" version="1">MSGPVTFEKTFRRDALIDIEKKYQKVWAEEKVFEVDAPTFEECPIEDVEQVQEAHPKFFATMAYPYMNGVLHAGHAFTLSKVEFATGFQRMNGKRALFPLGFHCTGMPIKAAADKIKREVELFGSDFSKAPADDEDAEESQQPAKTETKREDVTKFSSKKSKAAAKQGRAKFQYEIMMQLGIPREEVAKFANTDYWLEFFPPLCQKDVTAFGARVDWRRSMITTDANPYYDAFVRWQINRLRDVGKIKFGERYTIYSEKDGQACLDHDRQSGEGVGPQEYVGIKIRLTDVAPQAQELFKKENLDVKENKVYLVAATLRPETMYGQTCCFVSPKIDYGVFDAGNGDYFITTERAFKNMSFQNLTPKRGYYKPLFIINGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSPDDFVTTRDLANKPEYYGIEKDWVQTDIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLANAKELAYKEGFYNGTMLIGKYKGDKVEDAKPKVKQDLIDEGLAFVYNEPESQVISRSGDDCCVSLEDQWYIDYGEEAWLGEALECLKNMETYSKETRHGFEGVLAWMKNWAVTRKFGLGTKLPWDPQYLVESLSDSTVYMAYYTIDRFLHSDYYGKKAGKFDIKPEQMTDEVFDYIFTRRDDVETDIPKEQLKEMRREFEYFYPLDVRVSGKDLIPNHLTFFIYTHVALFPKRFWPRGVRANGHLLLNNAKMSKSTGNFMTLEQIIEKFGADASRIAMADAGDTVEDANFDEANANAAILRLTTLKDWCEEEVKNQDKLRTGDYDSFFDAAFENEMNDLIEKTYQQYTLSNYKQALKSGLFDFQIARDIYRESVNTTGIGMHKDLVLKYIEYQALMLAPIAPHFAEYLYREVLGKNGSVQTSKFPRASKPVSKAILDASEYVRSLTRSIREAEGQALKKKKGKSDVDGSKPISLTVLVSNTFPEWQDNYIELVRELFEQNKLDDNNVIRQKVGKDMKRGMPYIHQIKTRLATEDADTVFNRKLTFDEIDTLKNVVEIVKNAPYSLKVEKLEILSFNNGETKGKNIISGEDNIELNFKGKIMENAVPGEPGIFIKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS34</accession>
    <name>A0A1D8PS34_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_CR01950WA</name>
        <name evidence="11" type="ordered locus">orf19.10125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718259.2">
        <property type="nucleotide sequence ID" value="XM_713166.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS34"/>
    <dbReference type="SMR" id="A0A1D8PS34"/>
    <dbReference type="FunCoup" id="A0A1D8PS34">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PS34"/>
    <dbReference type="GeneID" id="3640107"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01950WA"/>
    <dbReference type="CGD" id="CAL0000185748">
        <property type="gene designation" value="orf19.10125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01950W_A"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS34"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1060:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase I subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="126"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000185748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="299" mass="33482" checksum="AB98D7C17C44A754" modified="2017-01-18" version="1">MSVEVRKRPADNFSSASKRRATVQSTNPKDGNGLSECFKTVSTSLYVSLAPVHLQNPINGIKQQHLDPLIMTYFTKAKGIVVAYSNIKFLENNYDNEDSAYSLAKIEGSSPFTFLWISVDFLCWCPEVGDVLEGDIYMQTPSHIGLLICDTFNASIKKYNIPNTWSFVPNQIDEVSSDDRKTFGHWVDESKTKVEGKLQFTIKAIHTTGRIVSVEGTLIRPGEERNAQPVYKERSETKSTGKHMKFADDEVITTTEIAEPDENDELPAYIKDSDDEDSGSDDNKVVNNSDSDEDKIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSC6</accession>
    <name>A0A1D8PSC6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAALFM_CR02970CA</name>
        <name evidence="18" type="ordered locus">orf19.10376</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715788.2">
        <property type="nucleotide sequence ID" value="XM_710695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSC6"/>
    <dbReference type="SMR" id="A0A1D8PSC6"/>
    <dbReference type="FunCoup" id="A0A1D8PSC6">
        <property type="interactions" value="1050"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSC6"/>
    <dbReference type="GeneID" id="3642603"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02970CA"/>
    <dbReference type="CGD" id="CAL0000180210">
        <property type="gene designation" value="orf19.10376"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02970C_A"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSC6"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001111">
        <property type="term" value="P:RNA polymerase II promoter clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="366"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="582"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
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        </location>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSG1</accession>
    <name>A0A1D8PSG1_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">Aprataxin C2HE/C2H2/C2HC zinc finger domain-containing protein</fullName>
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        <name evidence="4" type="ordered locus">CAALFM_CR03440WA</name>
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="259" mass="30219" checksum="CAD4E983FEDE3573" modified="2017-01-18" version="1">MSFRDAFQKYIDHPERHDIVLFHDQNVIIIKDMFPKSTRHLLVIPRNRQVTKNHPLDAFCTDYPEFTGHELYNMVSGYVEKAKDLIIDELFRYSNVNDKSQLSEFRNTFIKAGVHSIPSLNNLHVHVITQDFHSPRMRNKKHYNSFTTKFFVPFEELNPELNESYCRRTSQPFSETESSQSSNSDRNSSTQYIVHERSTQVMEKLIKTTPFKCTSCSKTFGNSMVKLKAHLHEEYTKKYASFIVPNILIPNGVCAPCTK</sequence>
</entry>
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    <name>A0A1D8PSW7_CANAL</name>
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        <recommendedName>
            <fullName evidence="7">Outer spore wall assembly protein SHE10</fullName>
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    <reference evidence="5 6" key="1">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711994.2">
        <property type="nucleotide sequence ID" value="XM_706901.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSW7"/>
    <dbReference type="GeneID" id="3646388"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05030WA"/>
    <dbReference type="CGD" id="CAL0000182238">
        <property type="gene designation" value="orf19.8264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05030W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PSW7"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="893"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000182238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="112542" checksum="CE3EEB3E8AB33DF5" modified="2017-01-18" version="1">MAYGIRLIGGIITLYLFYVWTFVCPLTTIDTESTNSLTPINHHFCSLSNKYIKPQFYPIYQAHINPVLINLDESLHVGENIDKSIEIIHNFNHQYKISDYYHRVCDLLIDSTQQGINYFQDNITPQLSRWFKLFILRIRMYYEISKINLEYYLYPTINKTYKQVVDKLKSIEFINDFINWINEIYLKLATSKHALKLQQKSNFLQNEFKNLVTFDDFNPKEIKNNVLQIVKDMLGEKSIDEKSIEQTLTDEPTGDEIPLELTPTEQTISSETANNNVSGDDEVHVEEVSAEETPDEEVPVEETPIEEAPIEEIPTEEEPIEETFKEETTIEETPTEEIFIEETHIEDTPIEKYKAEVEEEEEVVIEEEVVVEEDEIEIEPEIPSSNDDEDEDDSELEPETIHLTSTIVVTQSESEVTGVNDAVSTDDPVWGPILHEINYWETKVNKTMILALNNLKIEMKPKIDEIINDIKPEISDILQDLQKTNYEQYQLIHRKISQINKDYEEIKLTNNSLIETITRQEIRDDISNCTKTSEDASSKIQEILNNNHEKLLTIFYEVLQDTIDILETSSESVINEFKNQLNYFIYQSDLKDDDEINWTIWKKYHKIKESLFEFRDNLIKDADDYQVDNKKNSVDKLTNDSLNEWDNYLKNIEFHLNFLISDNIEFLQLIRAKANIAFQMREGLVDELNRIEKEKQEQLEKEKEREQKKAKDIKIETPELVDIPNGAGGVVDAKQVYFEYSDDSEGLGNFVNDSIIIESEDLDKSETISQQSSTVSEIYYYEHTVGPNEDVADANDFIVETTIVESEPSTVSGEVEISNMDQEVIEEEVVEEVEIEIEIDTDVEFEFETEIETEIETKTQLDIQFDTDVEIEFETEYETQIETAFATEIGVSDVETSSVDTSSSIADVTSQSIESSPIESVVDKDDNNDDNNDSDDDEDDDYEVVVEEEQILILEEEEEEEDEQETAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTB7</accession>
    <name>A0A1D8PTB7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_CR06930WA</name>
        <name evidence="5" type="ordered locus">orf19.178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710018.2">
        <property type="nucleotide sequence ID" value="XM_704926.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTB7"/>
    <dbReference type="SMR" id="A0A1D8PTB7"/>
    <dbReference type="GeneID" id="3648382"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06930WA"/>
    <dbReference type="CGD" id="CAL0000181655">
        <property type="gene designation" value="orf19.178"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06930W_A"/>
    <dbReference type="eggNOG" id="ENOG502T2NA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTB7"/>
    <dbReference type="OrthoDB" id="3993572at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PEX11"/>
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        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000181655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="321" mass="37303" checksum="781694B8D9849705" modified="2017-01-18" version="1">MVTTTIQENIDLIQKVNLKHTSIDPNPDSRQQEIINNLLLLAQKEQQKGNTSITSDKLDKLTSLLAQQQQQQQQKLQSRSQPLSTPTKAKLPPKPKYPSVFNKFDINKSSHNNRQERGQSPVKKPKSGSKPNNNNKPIKYYRPNTFSLKKIEFMFVNILENLANLLDNLHLLSNLPMFPQFLNRFLKQTNKIWVLILVFLIRKTISQLLNVIRKIRKVNIEVDLLNSTTTTKNKTGINFINEDLNKKYKKVLKDLRFDKMMLIIELIGNFLDLTFNLIELYGIALPDWIMSLLNFASMAMTIYRMNKDDEYVDDDITDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTJ9</accession>
    <name>A0A1D8PTJ9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">HGT14</name>
        <name evidence="14" type="ordered locus">CAALFM_CR07730WA</name>
        <name evidence="13" type="ordered locus">orf19.2633</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710080.1">
        <property type="nucleotide sequence ID" value="XM_704988.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PTJ9"/>
    <dbReference type="SMR" id="A0A1D8PTJ9"/>
    <dbReference type="STRING" id="237561.A0A1D8PTJ9"/>
    <dbReference type="GeneID" id="3648320"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07730WA"/>
    <dbReference type="CGD" id="CAL0000194719">
        <property type="gene designation" value="HGT14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07730W_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PTJ9"/>
    <dbReference type="OMA" id="PADHIYM"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="70"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AOW31464.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="592" mass="66388" checksum="5E5479F7AADFF677" modified="2017-01-18" version="1">MSDEKTTATYESHTKQDSMSSTSSQSIEQISSPTKSEPKKKSWFKMKNLFEKVEDRPTPPQVYNYRIYMTAIMASAAAIIIGYDGGFIGGTVALDSFKNEFGLDKSAHSSFIISNVISVFHAGCFFGALFSYPFSFYLGRRIPLIFAAFLITAGSGIMLAANSSVGLGPIYAGRVMAGVAVGFSTNLTVVYISEIAPPAIRGQLTSSYEIGWRVGDLVGFWINYGVDSHIPEGKRQWYIPFAIQLIPSGLFLLGSIFMKESPRWLMQVGRYDEAIKNLTWFRQLPEDDEYIVYEVNQVKESIEEQKQKIGLGIMDPFYEVFFNNKLVLRRLLITMTIYVVCNFLGIQSINYYSPILFQGLGVKGTNASLFSTGMFGVVKFICTFIYILFIVDTVGRRKAFMASSTVCSLCFWYIGAYLKLNDPTKPGVSAGPGGKAAIAMMYIWIASFILAWSGGPFVVGSEVFDQNIRSFVQAINAAMSWVPIFIMSRFTTNMIRAMDYGIYFFFAALAVATIPFLFFCLPETKGIALEDMDRLFSPELPAWRAHDILMKRVQHETEEVFHENHKHGLFEAVDNKPVSENVEDILVNKEEK</sequence>
</entry>
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    <accession>A0A1D8PU31</accession>
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        </submittedName>
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        <name evidence="6 7" type="primary">YTA6</name>
        <name evidence="7" type="ordered locus">CAALFM_CR09860WA</name>
        <name evidence="6" type="ordered locus">orf19.7558</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_714227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU31"/>
    <dbReference type="SMR" id="A0A1D8PU31"/>
    <dbReference type="FunCoup" id="A0A1D8PU31">
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_CR09860WA"/>
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        <property type="gene designation" value="YTA6"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PU31"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030447">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="570"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000185972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="820" mass="90116" checksum="1B25EFBD02F20E3B" modified="2017-01-18" version="1">MFLRKKPPQISTLDELQQTYNDCCNLTIKNLTLEEENNVEDALKGWKSLHTSLLYKLDIFDKMSSKLNPEEKTILGELKGIRDENIKHLIRVQLRLDEVNRRKHREANHGAPPPPPPPRSTVSNSTSNINVPSTLRNSSSQSTSAGGAASRPMMKSLRPHSNGHSASSSSSLSKTHARLKPKSVQEASTAASASWTKPITSQQKYQISKSNLKSKKDDLFQDFDQDTYTPNRNDSGNWEKFANSRSSSGLSEYSNEEDGGDYNLIDLDDYNGNGSLSHSMDDLTIKPVISPKDASSSSAYTSIPAQQHHTPVQSKSSAGNANKSNGLLRPSQQMEHISKSTSDIRTKPKIPYVYTKPKPMNIQRLMRQSASQSKSSPSSSSPSNKPVTTSKVAATTAGKTAKPKPKSNITYNFVRAPAPGKLKAANSTPTTTSRPRTNGASAGTVNKQGSKQPSTSVRRPSKPAEDEQINSPTMDDLLSGYEDNPQNDLDEDDNSKNLILTNEKHQDKLIASIRGIDPTAAKQILNDVVVHGDEVYWDDIVGLEGAKNSLKEAVVYPFLRPDLFRGLREPTRGMLLFGPPGTGKTMLARAVATESNSTFFSISSSSLTSKYLGESEKLVKALFLLAKKLAPSIVFMDEIDSLLGARTEGEIESTRRIKNEFLVQWSELSSAAAGRETDDGDVSRVLILGATNLPWSIDEAARRRFVRRQYIPLPEDEARISQIKKLLKYQKNTLDDSDYNKLIELTKGFSGSDITALAKDSAMGPLRSLGDKLLSTPTEQIRPISLEDFENSLKYIRPSVSSDGLKEYEDWASKFGSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU59</accession>
    <name>A0A1D8PU59_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Utp5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">UTP5</name>
        <name evidence="7" type="ordered locus">CAALFM_CR10240WA</name>
        <name evidence="6" type="ordered locus">orf19.7599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719361.2">
        <property type="nucleotide sequence ID" value="XM_714268.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU59"/>
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    <dbReference type="GeneID" id="3638922"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10240WA"/>
    <dbReference type="CGD" id="CAL0000191285">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10240W_A"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
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        <location>
            <begin position="449"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="587"/>
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    </feature>
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        <source>
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        <source>
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        </source>
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        </source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000191285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="636" mass="71340" checksum="A6A1A5D5E5D65DC6" modified="2017-01-18" version="1">MSGPIICSKFDQSGNYLATGMVALDSHQVKVQSITSSQASLNTSFTLEKSNKLVNLAWIPSDSIQLLALCLSKGSILIYSPQTNEIVSELISSANVSILDFHYSTTTRTGWSCDIEGNVYEWDLNSYLLVDSFKVNEYIESVDSINRISTVMFNSQPHLLLGSNAVYLFNIKQRELVKTFPGHIQPVNSITALNNDMFLTSAKGDRFVNLYQLDKTATKAVFLGSSSVSSLSVSIKDDKSVLVIINEEGDIEIFNNPLADAKSQVSTPVPKKKRKQVGVSSRSFNASIKLSRPEPEIKSPQDTHLFINAVSTEDNLITFTWLENSTIPFFDTLKWIDETGSLLLESAKVLLKSKPNLKVTQHLTNGHDVAAPKLYTEGHTIVSDGSNIRDLEFQDHQEDEEDTEESLAEKLERLAMDQTSQQKSRRRKLEEARSGVSLSIVLTQSLKNNDQALLETVLSNRDPITIQNTISRLDPYSCVTFLDKLSEKIQRQPTRFDQVSFWLKWILVIHGPTMASLPNLSIKLSSLRAVLNKKAEELPRLLELQGRLKLMDDSAALRNEFSAEEIAEDLEERSDIEYNEEIDDAKYVGVISDDESMDDVDDFDDLDDEEEEEEEEEEDGIPDAANLDDREDSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU71</accession>
    <name>A0A1D8PU71_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">CTM1</name>
        <name evidence="6" type="ordered locus">CAALFM_CR10360CA</name>
        <name evidence="5" type="ordered locus">orf19.7612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719373.1">
        <property type="nucleotide sequence ID" value="XM_714280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU71"/>
    <dbReference type="FunCoup" id="A0A1D8PU71">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU71"/>
    <dbReference type="GeneID" id="3638951"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10360CA"/>
    <dbReference type="CGD" id="CAL0000189202">
        <property type="gene designation" value="CTM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10360C_A"/>
    <dbReference type="eggNOG" id="ENOG502RXKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU71"/>
    <dbReference type="OMA" id="DYINGID"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
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    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000189202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="686" mass="79068" checksum="4DB4B220FA6EEA1D" modified="2017-01-18" version="1">MPPKPLVPRTLHIPGVKRNGDLLYYIGDNGITFHPNLTIDRSLLGGIGLFFNPGEGGGNESTQTPQGTIVNSNVKQSFQSVADVELLRIPRRSTFTIHTLVRLLEELKIRDKLITIDNINVPPIKESELIINFLNCMEPTTETHILITYFLAFHTIKKFRQRLSPKSPYYQESPVMQLNTYLNILSATSTIKYPADHFHKKSDYISRDIDDEFVSTYCEMSQKIKLEYESLIEQLHALYHDVPLFDIAKLLSFESYFQICQAVRSRILEIPRDAHNDIDDVVGPPLKKMKAREAQGEPSENAVTTGLQELSINPEEGKSNVGSGRNDTEHTNNTDDYVIDVSLVPILDFVNHNHHSNSYFDIDRRTNDIVLKLRSNVQMIANEKFEVTISYDPEDNIKEFLYTYGFFPKIVNNKIGVSANFNENDNIQLFELKLNNLDRYIPKSQYLCRWLKVLPQIQLVIKYASSDTVDNANSNNESNMRVYFNFFSNNLPLLFIPEIAYNAGWLDVLIPHFIKYNNIPPNCRTNIDALELVNMFIYQEKHCDYINGIDPIGVKLTTTDDDNVGSSRKAPVLLSDLSNILQVTNSDFEDLIKKTLEFIVTVYLNEQVEHLKDQLDLKKKLVMCGLANNFDELVDKYQRFKFRVFQQIIKQYKEDLSSLILPESIAKRAWETKYRTPPREFIFECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QT1</accession>
    <name>Q59QT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mlc2p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C503370CA</name>
        <name evidence="2" type="ordered locus">orf19.10165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712025.1">
        <property type="nucleotide sequence ID" value="XM_706932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QT1"/>
    <dbReference type="SMR" id="Q59QT1"/>
    <dbReference type="FunCoup" id="Q59QT1">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59QT1"/>
    <dbReference type="GeneID" id="3646350"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503370CA"/>
    <dbReference type="CGD" id="CAL0000190405">
        <property type="gene designation" value="orf19.10165"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03370C_A"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1594307_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QT1"/>
    <dbReference type="OMA" id="EQMDGTQ"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140659">
        <property type="term" value="F:cytoskeletal motor regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032036">
        <property type="term" value="F:myosin heavy chain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000190405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19328" checksum="D78F778D653505BF" modified="2005-04-26" version="1">MSHLTTLSSTQKAQIRNTFTLIDGESRDSTITKDDLVKLYSTLGLPPPSESQLTEMLTVDGQDKSQTGINFTQFSNIMAKELSKFEDQSIIYNALKVYSDKENLKTFKDELQIDVNKLKDACCSVQLREIGSGDHRLSRAKFDKLVEGFVQEQMDGTQIFLASKWIDAYID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2025-06-18" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SU1</accession>
    <accession>A0A1D8PJX2</accession>
    <name>CARP9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Secreted aspartic protease 9</fullName>
            <shortName evidence="19">ACP 9</shortName>
            <shortName evidence="19">Aspartate protease 9</shortName>
            <ecNumber evidence="12 14 15">3.4.23.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Candidapepsin-9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SAP9</name>
        <name type="synonym">YPS1</name>
        <name type="ordered locus">CAALFM_C303870CA</name>
        <name type="ORF">CaO19.14190</name>
        <name type="ORF">CaO19.6928</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="J. Antimicrob. Chemother." volume="55" first="645" last="654">
            <title>Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.</title>
            <authorList>
                <person name="Copping V.M.S."/>
                <person name="Barelle C.J."/>
                <person name="Hube B."/>
                <person name="Gow N.A.R."/>
                <person name="Brown A.J.P."/>
                <person name="Odds F.C."/>
            </authorList>
            <dbReference type="PubMed" id="15820985"/>
            <dbReference type="DOI" id="10.1093/jac/dki088"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1998" name="Microbiology" volume="144" first="2731" last="2737">
            <title>Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans.</title>
            <authorList>
                <person name="Monod M."/>
                <person name="Hube B."/>
                <person name="Hess D."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="9802014"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2006" name="J. Biol. Chem." volume="281" first="688" last="694">
            <title>Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.</title>
            <authorList>
                <person name="Albrecht A."/>
                <person name="Felk A."/>
                <person name="Pichova I."/>
                <person name="Naglik J.R."/>
                <person name="Schaller M."/>
                <person name="de Groot P."/>
                <person name="Maccallum D."/>
                <person name="Odds F.C."/>
                <person name="Schafer W."/>
                <person name="Klis F."/>
                <person name="Monod M."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="16269404"/>
            <dbReference type="DOI" id="10.1074/jbc.M509297200"/>
        </citation>
        <scope>GLYCOSYLATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="J. Biochem." volume="150" first="431" last="438">
            <title>Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.</title>
            <authorList>
                <person name="Aoki W."/>
                <person name="Kitahara N."/>
                <person name="Miura N."/>
                <person name="Morisaka H."/>
                <person name="Yamamoto Y."/>
                <person name="Kuroda K."/>
                <person name="Ueda M."/>
            </authorList>
            <dbReference type="PubMed" id="21646240"/>
            <dbReference type="DOI" id="10.1093/jb/mvr073"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Infect. Immun." volume="77" first="5216" last="5224">
            <title>The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.</title>
            <authorList>
                <person name="Hornbach A."/>
                <person name="Heyken A."/>
                <person name="Schild L."/>
                <person name="Hube B."/>
                <person name="Loffler J."/>
                <person name="Kurzai O."/>
            </authorList>
            <dbReference type="PubMed" id="19805528"/>
            <dbReference type="DOI" id="10.1128/IAI.00723-09"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="Peptides" volume="48" first="49" last="58">
            <title>Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.</title>
            <authorList>
                <person name="Bochenska O."/>
                <person name="Rapala-Kozik M."/>
                <person name="Wolak N."/>
                <person name="Bras G."/>
                <person name="Kozik A."/>
                <person name="Dubin A."/>
                <person name="Aoki W."/>
                <person name="Ueda M."/>
                <person name="Mak P."/>
            </authorList>
            <dbReference type="PubMed" id="23927842"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2013.07.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1071" last="1081">
            <title>Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.</title>
            <authorList>
                <person name="Sorgo A.G."/>
                <person name="Heilmann C.J."/>
                <person name="Dekker H.L."/>
                <person name="Bekker M."/>
                <person name="Brul S."/>
                <person name="de Koster C.G."/>
                <person name="de Koning L.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="21622905"/>
            <dbReference type="DOI" id="10.1128/EC.05011-11"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2016" name="Acta Biochim. Pol." volume="63" first="403" last="410">
            <title>The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5.</title>
            <authorList>
                <person name="Bochenska O."/>
                <person name="Rapala-Kozik M."/>
                <person name="Wolak N."/>
                <person name="Aoki W."/>
                <person name="Ueda M."/>
                <person name="Kozik A."/>
            </authorList>
            <dbReference type="PubMed" id="27390786"/>
            <dbReference type="DOI" id="10.18388/abp.2016_1318"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2018" name="FEBS J." volume="285" first="146" last="159">
            <title>Engineering improved variants of the antifungal peptide histatin 5 with reduced susceptibility to Candida albicans secreted aspartic proteases and enhanced antimicrobial potency.</title>
            <authorList>
                <person name="Ikonomova S.P."/>
                <person name="Moghaddam-Taaheri P."/>
                <person name="Jabra-Rizk M.A."/>
                <person name="Wang Y."/>
                <person name="Karlsson A.J."/>
            </authorList>
            <dbReference type="PubMed" id="29143452"/>
            <dbReference type="DOI" id="10.1111/febs.14327"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2020" name="Protein Sci." volume="29" first="480" last="493">
            <title>Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis.</title>
            <authorList>
                <person name="Ikonomova S.P."/>
                <person name="Moghaddam-Taaheri P."/>
                <person name="Wang Y."/>
                <person name="Doolin M.T."/>
                <person name="Stroka K.M."/>
                <person name="Hube B."/>
                <person name="Karlsson A.J."/>
            </authorList>
            <dbReference type="PubMed" id="31675138"/>
            <dbReference type="DOI" id="10.1002/pro.3767"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9 10 13">Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:15820985, PubMed:16269404, PubMed:19805528). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (PubMed:15820985, PubMed:16269404, PubMed:19805528). Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein (PubMed:23927842).</text>
    </comment>
    <comment type="function">
        <text evidence="14 15 16">Plays a key role in defense against host by cleaving histatin-5 (Hst 5), a peptide from human saliva that carries out fungicidal activity (PubMed:27390786, PubMed:29143452, PubMed:31675138). The cleavage rate decreases in an order of SAP2 &gt; SAP9 &gt; SAP3 &gt; SAP7 &gt; SAP4 &gt; SAP1 &gt; SAP8 (PubMed:27390786). The first cleavage occurs between residues 'Lys-17' and 'His-18' of Hst 5, giving DSHAKRHHGYKRKFHEK and HHSHRGY peptides (PubMed:27390786). Simultaneously, the DSHAKRHHGYKRK peptide is also formed (PubMed:27390786). Further fragmentation by SAP9 results in FHEK product (PubMed:27390786).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 15 16">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="12 14 15">Optimum pH is 5.5 using casein-resorufin as substrate, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5.</text>
        </phDependence>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Lipid-anchor</topology>
            <topology evidence="19">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 11">Secreted</location>
            <location evidence="9 11">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="8 11 17">Induced by fluconazole (PubMed:15820985, PubMed:21622905). Expression is regulated by growth phase, temperature, and white-opaque switch (PubMed:9802014).</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="12 14 15"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712729.2">
        <property type="nucleotide sequence ID" value="XM_707636.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SU1"/>
    <dbReference type="SMR" id="Q59SU1"/>
    <dbReference type="FunCoup" id="Q59SU1">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SU1"/>
    <dbReference type="MEROPS" id="A01.067"/>
    <dbReference type="GlyCosmos" id="Q59SU1">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_03870C_A-T">
        <property type="protein sequence ID" value="C3_03870C_A-T-p1"/>
        <property type="gene ID" value="C3_03870C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645625"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303870CA"/>
    <dbReference type="CGD" id="CAL0000194661">
        <property type="gene designation" value="SAP9"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03870C_A"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="Q59SU1"/>
    <dbReference type="OMA" id="IWGYDDV"/>
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        <property type="organism ID" value="1096"/>
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    <dbReference type="PRO" id="PR:Q59SU1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052156">
        <property type="term" value="P:symbiont-mediated perturbation of host T-cell mediated immune response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000023">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424304" description="Secreted aspartic protease 9">
        <location>
            <begin position="18"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424305" description="Removed in mature form" evidence="4">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="371"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="4">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0CS83"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0CY27"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P0CY29"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="15820985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="16269404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="19805528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="21622905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="21646240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="23927842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="27390786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="15">
        <source>
            <dbReference type="PubMed" id="29143452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="16">
        <source>
            <dbReference type="PubMed" id="31675138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="17">
        <source>
            <dbReference type="PubMed" id="9802014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="18">
        <source>
            <dbReference type="PubMed" id="9802014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="19"/>
    <sequence length="544" mass="58483" checksum="4EC6144F27F97B47" modified="2017-03-15" version="2" precursor="true">MRLNSVALLSLVATALAAKAPFKIDFEVRRGESKDDLSPEDDSNPRFVKRDGSLDMTLTNKQTFYMATLKIGSNEDENRVLVDTGSSDLWVMSHDLKCVSAPNSKRNERSFGHGTGVKLNERELMQKRKNLYQPSRTIETDEEKEASEKIHNKLFGFGSIYSTVYITEGPGAYSTFSPFVGTEGGSGGSGGSNTCTSYGSFNTENSDTFKKNNTNDFEIQYADDTSAIGIWGYDDVTISNVTVKDLSFAIANETSSDVGVLGIGLPGLEVTTQYGYTYQNLPLKLKADGIIAKSLYSLYLNTADAKAGSILFGAIDHAKYQGDLVTVKMMRTYSQISYPVRIQVPVSKIDVESSSGSTTNILSSTTGVVLDTGSTLSYVFSDTLQSLGKALNGQYSNSVGAYVVNCNLADSSRTVDIEFGGNKTIKVPISDLVLQASKSTCILGVMQQSSSSSYMLFGDNILRSAYIVYDLDDYEVSLAQVSYTNKESIEVIGASGITNSSGSGTTSSSGTSTSTSTRHSAGSIISKPVYGLLLSLLISCYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T35</accession>
    <name>Q59T35_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate reductase</fullName>
            <ecNumber evidence="4">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">OSM1</name>
        <name evidence="7" type="ordered locus">CAALFM_C205700WA</name>
        <name evidence="6" type="ordered locus">orf19.14171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712811.1">
        <property type="nucleotide sequence ID" value="XM_707718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59T35"/>
    <dbReference type="SMR" id="Q59T35"/>
    <dbReference type="STRING" id="237561.Q59T35"/>
    <dbReference type="GeneID" id="3645573"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205700WA"/>
    <dbReference type="CGD" id="CAL0000197318">
        <property type="gene designation" value="OSM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05700W_A"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="InParanoid" id="Q59T35"/>
    <dbReference type="OMA" id="GEHEAMD"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000197318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="503" mass="54343" checksum="1AC2EE7C2F643078" modified="2005-04-26" version="1">MSKILSSIPGNMSKSIAKYDTIVIGSGLAGLTTTYQLSKAGQKVALLEKSEKLGGNSIKASSGINGVPTKYQKQPSTDSIESFVQDTLKTGKNLNDKKMVDILTKNSRDAIYWLSDEINVDLSNVVLLGGHSHARTHKGDKLPPGFAIVSALTKKLDGFQAENPDQLTILKSSTLTKILTEGNKVKGIEFTDSEKQPQEMYADNVVLATGGFSADFDSPTSLLQKYRPDLLGFPSSNGAQTTGDGQKIAERDVNAELIHMDKVQVHPTGFMKVSNPNENWKFLCGELMRGIGGILLSPVTGWRFVDELQPRDVVTDAVLKHSQIGQNNEIGLKSDNGDGYGSVIVISGNDYQKATTHIEFYKSQGLLQEGSIEDLYYLLIKLNPKLPLTLDQLKDKFSGCDAIIEGTQQDSLGRTKFGGRFGDLKKLYFGVTTPVVHFTMGGIKVNPSNAKVVTKSGDTISNLFAIGEVSAGVHGNNRLGGSSLLECVVFGRFVSENILSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TL8</accession>
    <name>Q59TL8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C403580WA</name>
        <name evidence="2" type="ordered locus">orf19.8898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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        </source>
    </reference>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <location>
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            <end position="48"/>
        </location>
    </feature>
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        <location>
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            <end position="26"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
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            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000177280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="357" mass="41625" checksum="F4EA6C2849051C24" modified="2005-04-26" version="1">MSKQDPPPDYTNRTSDNYNPDTTDNHNIPPPFTTHPIEVHPPPFSSSTSPNIRVPAYFQNQTTSGWTIVINNRFWTDGFRIFVSEDASNKFDAFKKSKNPEIIQLQEQGIGVPLFKAVTSYIPLATKFITFRRYVPTNLHPFDIDKDYYDYCIVKRKLHVGYDSYIFEFTPDPKQPKLNFQVILFSHSILPIHDYIYKGERHRWIDESNLRGFKARWQVKYGFKHTYLIDGQPALTDNWDGKSDKLNKDKKNPYLDNFLKMKFSVSSRFPKQEYYGPHCTDTLGEAEAFFKLGYAELKIDDLGRGIPEGDDDNGDDVNYESIFSIPEDELVTICIATVLKRQKDIEEEKKNRRKRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q59U61</accession>
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        <submittedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">CAALFM_C207410WA</name>
        <name evidence="4" type="ordered locus">orf19.9446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
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                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="488" mass="55324" checksum="C0759F53AD05DCE7" modified="2005-04-26" version="1">MSGFFVSRVESHFSKNPIKFKPRSNSSHEANNNTTSNLINKFKPKKTSKGTDNELPNSIPEMIQTAIPEFSPKYSFFVNPLLSSGHTQTAYTALNKFENQHEVHYKREIITIENKPYTLPNGDQLYYDQWKGESTIALDYAVNSSLGPDLNHEQYKPESQTRPLPPRTEFKNPNEDLISDDEKPLLIILHGLSGGSYEAYLRAVIDKIIEPPFEFDAMVINSRGCANHTITSPQLYNGLWTNDVRYVINEIVSKRWPQKRVFLMGFSLGAAILANYLGQEGAHASPQIKGSVAIGCPWDFVDGSFQLRESVIGHYIYSPTMANNLLKLLNSHHILLANDLVKQYKEDPTRNEIKFLKQFDNEFTAKMFGLNSADEYYRKASPIQRLLNVRVPMVILSSLDDPVVGSRSLPYSEVNLNPYVSLITTSVGGHLGWFAINGDRWYVEPVCKLLTVLNQYDADKESIVELPVDISETSWKYDRLVNGMLVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">SH3 domain-containing protein</fullName>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713118.1">
        <property type="nucleotide sequence ID" value="XM_708025.1"/>
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    <dbReference type="AlphaFoldDB" id="Q59U90"/>
    <dbReference type="STRING" id="237561.Q59U90"/>
    <dbReference type="GeneID" id="3645192"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207640WA"/>
    <dbReference type="CGD" id="CAL0000196693">
        <property type="gene designation" value="orf19.9417"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C2_07640W_A"/>
    <dbReference type="eggNOG" id="ENOG502T2HC">
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    <dbReference type="InParanoid" id="Q59U90"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0043332">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
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    </dbReference>
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        <location>
            <begin position="554"/>
            <end position="624"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000196693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="624" mass="72743" checksum="8AD7EB7EFA9932B8" modified="2005-04-26" version="1">MVVDQLKNNIVSISSNIGTHIKDGYKYTESEFKNISYNIKDTVTFHTRDYDKDDELVEIYYHDIKQSVSGLKYITSQNHHLSKSFLPHVLSSNIKIIKGFINLIGQDSLRFDKINEYYQEFDSWQATQEIPHVHPKEMQFLNESINEELNNYLITVENLKFDLENNWEAYDESLKYRIDEMKKYLKKTLKLIKKRNMKRTEQDHLHRKIEKLNQKAIPLDEKDNDKLEKLETTYQTVDAAFNSLNKKCIQLLPNIVSFLDEFVENITKMILCQQLETFKKLTDTFQYFTEFYGLIKENSPKSYTEIIDDWESNSTATRLQIESLLTIVHEKHPDLLDKEINDEDSSSNYYRFWRNMSNKFVEKKHVVNTKDKVNGIFNDTLEIDPLVAYKQYQDPSMNPSETYHPRKLVDEEDIKVPAVPKKDGPELPPRSNTAIVRHSVLVSPMSSAGASRLYSISTDSMDSISLSDFEDESATIMSEASSISSMSSVSYSNHDSSEAKLRRIYNGSKNEIKESPITTKPIQYEPFTFEKPMSLTYKLNLIQSFFEKLNINTDNKVLKTAKYDFSGYEPGDLSFKQGDNIEILLDFQNIDTLYHSDELNWLIGVSRIDDESYRIGFVPNNYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VX6</accession>
    <name>Q59VX6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cwh8p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">CWH8</name>
        <name evidence="9" type="ordered locus">CAALFM_C102250WA</name>
        <name evidence="8" type="ordered locus">orf19.11166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713776.1">
        <property type="nucleotide sequence ID" value="XM_708683.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VX6"/>
    <dbReference type="SMR" id="Q59VX6"/>
    <dbReference type="FunCoup" id="Q59VX6">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VX6"/>
    <dbReference type="GeneID" id="3644598"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102250WA"/>
    <dbReference type="CGD" id="CAL0000176202">
        <property type="gene designation" value="CWH8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02250W_A"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074922_1_2_1"/>
    <dbReference type="InParanoid" id="Q59VX6"/>
    <dbReference type="OMA" id="LTVYQHE"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
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        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000176202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW25910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="241" mass="27736" checksum="BF2DD0ACDEF3F579" modified="2005-04-26" version="1">MMLDYNPVPFDHTYILYDPNDIIAKICVQFSLLPIYLMVFYTSWFLITREIEPVIIVGGHLINELINKIIKVSIKSPRPDFHKNFGRDGGSYGMTYGFPSAHSQFMGFFAGYYICVILLKVPMPKSSKKPICLFAAISMMGVAFSRVYLLYHSNVQVIAGLITGVTLGIIYFIITSVARDVGLVEWILNWPIIKYFYVKDTYYHIYQTFAEEYEVYLQLRRERNEALLSAIIGNEKNSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VZ6</accession>
    <name>Q59VZ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pho91p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">PHO91</name>
        <name evidence="10" type="ordered locus">CAALFM_C102050CA</name>
        <name evidence="9" type="ordered locus">orf19.11147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713757.1">
        <property type="nucleotide sequence ID" value="XM_708664.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VZ6"/>
    <dbReference type="SMR" id="Q59VZ6"/>
    <dbReference type="FunCoup" id="Q59VZ6">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VZ6"/>
    <dbReference type="GeneID" id="3644588"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102050CA"/>
    <dbReference type="CGD" id="CAL0000176776">
        <property type="gene designation" value="PHO91"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02050C_A"/>
    <dbReference type="eggNOG" id="KOG1281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_8_0_1"/>
    <dbReference type="InParanoid" id="Q59VZ6"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WC1</accession>
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        <name evidence="4" type="ordered locus">orf19.11928</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
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        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
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    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <sequence length="821" mass="89459" checksum="D83677F6A50DFA87" modified="2005-04-26" version="1">MSRSQIVALLKEQLDTIKQKKSIKLNSLPSTTKPSELIDTIYEFLTSFDPSLELEKLAIQNSQLIELPSNFHKIASSIKYLDLHQNSISYIPQDFFYGFDSLEILDLASNDLEFLPDSLSSVTTLKVISIKDNSFKYISPQLGELPNLNLIEVSGNPSLLPSNDIIRAFQQQKPDLDWVGELKNYLVANRMLINSKIQEAMEKSSQKRQQVPKDSTPETSQTTSDPVIARSKSGSISTSFSSKASRRMGLIIKKSDENSDGSSKEDANNSLISGAVPDHVTTEGIPHVDSPTDISFQLPKSPPTSTPGTTTPSTQAAPATTSTNKNLGVTSTSSARGRSNTFKEIDRMLEKSESVDTERKSNAYFKRLSTLQELPGDELSEYSQPKKPAAEGKQASGNVSKSNNTAASENSPAKPQQQSKLHTNPVIIRVSRKILFSFSELHSSIRRFTSFCSDKKVTMKMVSYLYSTKSNIDSLVENLEIMEESGDNSEQIVQALHNCIGSFKSIMKLLHENIQSFVGNIEVCFIRMVYLSVFGSLNELQNAYLLLCPKASAKSSSTEMKQKLSINTTTDADEKLYSTIESATSSTQTIFSELNKTINKGATASANGGVVHPTVASKIKELAKVCAASLDIIKRLNTKLITIRNNPSVTTKKLFAEDINQFIKTVVQTLAAVKAIVKDIPILDDIRASMSNLTKTAKEVTYFLEVSSYKSLLPDSSSTGVSQQPQLISVPSVSNLFTPVAAHAPSLPTSGGQAASNGPTPIRNPSTNSSITTTTLVLPPLNLQESAPLTAPVQSSGQMFAKHGLNPFDGLIMARNNDNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q59X45</accession>
    <name>Q59X45_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C209250WA</name>
        <name evidence="3" type="ordered locus">orf19.11567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714257.1">
        <property type="nucleotide sequence ID" value="XM_709164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59X45"/>
    <dbReference type="SMR" id="Q59X45"/>
    <dbReference type="FunCoup" id="Q59X45">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59X45"/>
    <dbReference type="GeneID" id="3644065"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209250WA"/>
    <dbReference type="CGD" id="CAL0000176562">
        <property type="gene designation" value="orf19.11567"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09250W_A"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047845_3_0_1"/>
    <dbReference type="InParanoid" id="Q59X45"/>
    <dbReference type="OMA" id="MPLNYSF"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17661">
        <property type="entry name" value="PFA-DSP_Oca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000152">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF74">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-LIKE PROTEIN OCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000176562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="216" mass="25155" checksum="AD88487B727A51D3" modified="2005-04-26" version="1">MQQETNNTQYVSNNKHSEESSRKISRSVVKLVPPLNFSLVENGIYRSGFPMPINYPFLKQLRLKTIIYLGDLGNQTSKKGKKKDKHGTAEIMNNYLDWIKNDTEIRFYNLLFESSQEPFNKPDDIQQATQSLTFALQLILNKENYPILIHSNKGKHRTGVLIGIMRKVLQGWCLSGIFEEYEKFAMGKSEYDLELIELWQPELYIDDANKPDFVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YG2</accession>
    <name>Q59YG2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C209870WA</name>
        <name evidence="9" type="ordered locus">orf19.8944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714538.1">
        <property type="nucleotide sequence ID" value="XM_709445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YG2"/>
    <dbReference type="GeneID" id="3643780"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209870WA"/>
    <dbReference type="CGD" id="CAL0000184190">
        <property type="gene designation" value="orf19.8944"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09870W_A"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_0_1"/>
    <dbReference type="InParanoid" id="Q59YG2"/>
    <dbReference type="OMA" id="ISQCVYY"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000184190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="345" mass="39185" checksum="4198203879F91035" modified="2005-04-26" version="1">MSSIVYNMLTTAGSPITTIQPSTWRTQISGVMGSTSLACWIVLLMPQLIEQWRLKSAEGIAIGFITIWFMGDIFNLIGALWAKLLPEVIFLAVWFCIADFLMIFSYVYYTKIYPKHHHQHHHHEHGQGDNEENHHHHHHHHHNKRKSRGNDNESSPLLNTTRSRSSSTGHGDSTHKRTRRRSSTLTDIALEPEYHSIFIKYILPILFVIGCGTLGFFISGTSGENNSPDDNTPPSPPPSDDIIAIGPQVMGYCSALLYLGARIPQIIQNHQRKSVHGLSLLFFLFSTLGNLTYAGQILFYRNDSQYILLNLSWLLGSLGTIFEDSLIFLQFYMYRDNNKDEATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q59YH5</accession>
    <name>Q59YH5_CANAL</name>
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        <submittedName>
            <fullName evidence="4">Mitochondrial 54S ribosomal protein YmL36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRPL36</name>
        <name evidence="4" type="ordered locus">CAALFM_C501700WA</name>
        <name evidence="3" type="ordered locus">orf19.10717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714621.1">
        <property type="nucleotide sequence ID" value="XM_709528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59YH5"/>
    <dbReference type="SMR" id="Q59YH5"/>
    <dbReference type="FunCoup" id="Q59YH5">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59YH5"/>
    <dbReference type="GeneID" id="3643733"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501700WA"/>
    <dbReference type="CGD" id="CAL0000174888">
        <property type="gene designation" value="orf19.10717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01700W_A"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130029_0_0_1"/>
    <dbReference type="InParanoid" id="Q59YH5"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
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    </dbReference>
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        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000174888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="210" mass="23763" checksum="460580F3DDD559B8" modified="2005-04-26" version="1">MLTRRIISLKPFPVSISTRSKATSASPTSNSTSPYGDVNLSNRRVMKRIVQGKARPAIFYQFETLVEMSDGSVIKRYSQAPKDEIRMINDQRNNLMWNPNNNDLRNGGIGGLGGDLQAKGKINKFKQKFANSFEEEEEEVGKQSKEGKEGKEEKKVEGEGEVDEEAIRRKQLELQKARDEELFELMGENAEEVVGGGKLYDKKADKKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A016</accession>
    <name>Q5A016_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_CR03730CA</name>
        <name evidence="10" type="ordered locus">orf19.11850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715148.1">
        <property type="nucleotide sequence ID" value="XM_710055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A016"/>
    <dbReference type="STRING" id="237561.Q5A016"/>
    <dbReference type="GeneID" id="3643226"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03730CA"/>
    <dbReference type="CGD" id="CAL0000177875">
        <property type="gene designation" value="orf19.11850"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03730C_A"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004979_2_2_1"/>
    <dbReference type="InParanoid" id="Q5A016"/>
    <dbReference type="OMA" id="AANYFCS"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="419"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000177875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="572" mass="63486" checksum="E1A86EBC983537E1" modified="2005-04-26" version="1">MNFYVFEESTRQCSIPSSTHNICSFIQKQCDTNYFKISELYYCYLTSSLPSLLLSSLLILVLLVVILISLSILVSNYLFQNLHNLTNVLGLNNQILSFILIPLTNSLPDILNYYIALDSGSTDLVIGQLMGSLLIMFTVIIGSISILNRGYIIDHPKILMLDLVIVLIVLILFSEILSDGKITNLECWTMITGYFLYILFLIFFDKDKLKESADEEQIWIEYSNNGSFTHPYNIEDAISILSSNDDEIASYGPVFSRSPSPLPDNTNSPNGSLSLSISSSSPRSSSPLCGPTESVTEESPLLLSVPGKFSTSESSPSISVNEDSEDEIIIQIPSRSKSFVQRAFDLVDCLFLTFVPYYRKIESNYSKTIICWYIMETTAIINYQFFQIPYKYVIPLSYIVAAILVHVQVSNNVQIVSISVAGLTVSLIIVSNLAIITLQLLKNLGVIWQISDYLLGLIVFAISNSLNDGITNVTISTKINPILGINSCIGTPLLIILLGIGGSGLIVTSRSHKDILFNLTDNVVISAAGLIFSICCLIIYLPWNNYRVDAKIGNFLLLLYIVMTGVEICLEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0L9</accession>
    <accession>A0A1D8PGU9</accession>
    <name>SMP3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>GPI mannosyltransferase 4</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>CaSMP3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GPI mannosyltransferase IV</fullName>
            <shortName>GPI-MT-IV</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SMP3</name>
        <name type="ordered locus">CAALFM_C203070CA</name>
        <name type="ORF">CaO19.13214</name>
        <name type="ORF">CaO19.5792</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Microbiology" volume="150" first="3115" last="3128">
            <title>Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans.</title>
            <authorList>
                <person name="Grimme S.J."/>
                <person name="Colussi P.A."/>
                <person name="Taron C.H."/>
                <person name="Orlean P."/>
            </authorList>
            <dbReference type="PubMed" id="15470093"/>
            <dbReference type="DOI" id="10.1099/mic.0.27254-0"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>May be used as a target for the development of some new fungicide, due the fact the presence of a fourth mannose in GPI-anchor proteins is essential for viability in fungi but not in mammals.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715333.2">
        <property type="nucleotide sequence ID" value="XM_710240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0L9"/>
    <dbReference type="FunCoup" id="Q5A0L9">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0L9"/>
    <dbReference type="GlyCosmos" id="Q5A0L9">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C2_03070C_A-T">
        <property type="protein sequence ID" value="C2_03070C_A-T-p1"/>
        <property type="gene ID" value="C2_03070C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642980"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203070CA"/>
    <dbReference type="CGD" id="CAL0000175734">
        <property type="gene designation" value="SMP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03070C_A"/>
    <dbReference type="HOGENOM" id="CLU_022957_2_0_1"/>
    <dbReference type="InParanoid" id="Q5A0L9"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="PRO" id="PR:Q5A0L9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246274" description="GPI mannosyltransferase 4">
        <location>
            <begin position="1"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="498" mass="57971" checksum="98A3C4952410BCE5" modified="2017-03-15" version="2">MIKINFNWRTFYLLTIVFRFVFTLSDSYIHPDEHFQSLEVLTNRILNYSTNIPWEFQDDPARSLAPLYFIYGPLLYFIKFFKLNLTALQIWYIARLQISILSWIITDFCLYWMLPSKPERIKAIFFTSTSYITLVYQNHLFSNSIETLLLLVTILLIDDLRYVQESKDQDVQNLNKNKNLFYTGVLISLGIFNRITFPAFLILPGWFVMKYVLKHYVSGLYLVMGFFSTTALLILVDTILFGNINNVVAEPFNVSSYIIAPLNNLLYNARYENLAQHGIHPYYTHILVNMPQILGPGLIFFVSKSYTKTTPFLTVISGLLFLSVIPHQELRFLIPLLPLACCSFDFTLKWVQPWMLYTWYIFNIFMSILMGKLHQGGVVPVLDHIKSEASVQVWWRTYTPPSWILGSNSTETTHLGEKLNDNKFINIVDCMGADSKEVQQILQTISTNKPVYLITPIASFKHFDESRFSPVWNYTFHLDLDHLDFADIQPGLGVYQLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1Q5</accession>
    <accession>A0A1D8PN70</accession>
    <name>NUF2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NUF2</name>
        <name type="ordered locus">CAALFM_C501280CA</name>
        <name type="ORF">CaO19.1941</name>
        <name type="ORF">CaO19.9496</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <text evidence="1">Associated with kinetochores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AOW29563" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29563.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715704.2">
        <property type="nucleotide sequence ID" value="XM_710611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1Q5"/>
    <dbReference type="SMR" id="Q5A1Q5"/>
    <dbReference type="BioGRID" id="1225707">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5A1Q5">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1Q5"/>
    <dbReference type="PeptideAtlas" id="Q5A1Q5"/>
    <dbReference type="GeneID" id="3642613"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501280CA"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025461_2_0_1"/>
    <dbReference type="InParanoid" id="Q5A1Q5"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="PRO" id="PR:Q5A1Q5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000009">
        <property type="entry name" value="Probable kinetochore protein NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000246647" description="Probable kinetochore protein NUF2">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="177"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="485" mass="56646" checksum="6ABB3AF17766C888" modified="2017-03-15" version="3">MSRQSFYADPSSAGRQMKYRKDLFPLLDTREITACLLECEFNVTQELIVKPTADFVTNLFEQFLDTFMGIPLGTIRKKARKMSRINPLESDQANGKPQQSPEEDFNDNQENDKTKDTFSALQLLILHRYLAIFFSTCGINDFVLTDIARPDGYRIRRILSAVINFIRFREDQSPKFDHLANECEATADKVSEVQAENSATMQKINAIKEKLEMDSENDESNRKNLQYINSYNRKLETKLRELKVMQERLTKEHDDYKQEKALLAKKLYDINFLYNETQEQVANLTKYAETDLSILVKITEDLSNDLSSMQTNYKNLEKSYQNMGITIDSIQVNEINLKDLLKLAEDITRNVEKRQIEGKILKDNQDNLDELTRKQMELEGQILIVQNQLNKSNKKYQDLIVQADKKESAVKLKLEETKQEFNDILSEKEKHNEEHKRIMDQIVKIQQETTAIQDAFVKESKEVELKLINLMSIIKRYMSDLRNNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-05-16" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1W9</accession>
    <accession>A0A1D8PN58</accession>
    <accession>Q5A1R1</accession>
    <name>HST3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>NAD-dependent histone deacetylase HST3</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Homologous to SIR2 protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Regulatory protein SIR2 homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HST3</name>
        <name type="ordered locus">CAALFM_C501340WA</name>
        <name type="ORF">CaO19.1934</name>
        <name type="ORF">CaO19.9490</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715697.2">
        <property type="nucleotide sequence ID" value="XM_710604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1W9"/>
    <dbReference type="SMR" id="Q5A1W9"/>
    <dbReference type="FunCoup" id="Q5A1W9">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1W9"/>
    <dbReference type="EnsemblFungi" id="C5_01340W_A-T">
        <property type="protein sequence ID" value="C5_01340W_A-T-p1"/>
        <property type="gene ID" value="C5_01340W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642641"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501340WA"/>
    <dbReference type="CGD" id="CAL0000186930">
        <property type="gene designation" value="HST3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01340W_A"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_4_0_1"/>
    <dbReference type="InParanoid" id="Q5A1W9"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="PRO" id="PR:Q5A1W9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900239">
        <property type="term" value="P:regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000417413" description="NAD-dependent histone deacetylase HST3">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="487" mass="55080" checksum="1483C2D2C161B1F6" modified="2017-03-15" version="2">MISIDLLDNSGTSMPADTSIKLHEVIKFISKSKKMTVLTGAGISCNAGIPDFRSSDGLYNMVKAKHPKAVVRGQDLFDISLFRDEMSLSVFCTFMESLYKSSLNAKPTETHKFIKILKDKNKLLRCYTQNIDCIEQHINLKLGINLQEFDNNKFKQVWNQLDVVQLHGNLHKLSCTNCFSQFNWNEEFQTLLANGLNPECSKCMDKYQQRLYSGKRLTGQTIGLLRPDIVLYGEHHPQMEILTQGLNSDLKSRPDCLIIMGTSLKVAGVKSLVKSLSKIIHNKGGKVIYVNKTKLSASSWKNYIDYEVVSDCDEFVRMLKTEIPDLFLTQEQLDSEKLNQVAVKGSSLNKPIVKPEAKVKIEPGIKQEDAIQYSPEREVTIKQEVNIKQEPIVKREVESVSVKEEPIPTPPTTPHKPKQATKLKRKSPDEISANEVHSRVKRLRPRNDQLSSPASSINGSEEEEEEDEPVAKVLFENARKGITLDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A2K9</accession>
    <name>Q5A2K9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C207870CA</name>
        <name evidence="2" type="ordered locus">orf19.2195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716035.1">
        <property type="nucleotide sequence ID" value="XM_710942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A2K9"/>
    <dbReference type="GeneID" id="3642319"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207870CA"/>
    <dbReference type="CGD" id="CAL0000190761">
        <property type="gene designation" value="orf19.2195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07870C_A"/>
    <dbReference type="HOGENOM" id="CLU_1495995_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A2K9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000190761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="180" mass="20004" checksum="D31AE5366D312BE1" modified="2005-04-26" version="1">MFLKNGNFFSKLGINSLYGSEIMIESNNGQTLNAAIEVIPKFIVNVANFSADSEMIDIIIISFIISALTLLPLAYPFSNNSIHWTLTKFSAKGNDRFRFLLILLLDPIENVLVLVVFCPNNIDNITRSSVLVNFPLVTIKSKCFCTGEIEDIFPDFLLSLNSDLKVPSINPLTVSMFFGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2025-06-18" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A446</accession>
    <accession>A0A1D8PME9</accession>
    <name>FRE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferric/cupric reductase transmembrane component 1</fullName>
            <ecNumber evidence="1">1.16.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ferric-chelate reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CFL1</name>
        <name type="synonym">FRE1</name>
        <name type="ordered locus">CAALFM_C405770CA</name>
        <name type="ORF">CaO19.1263</name>
        <name type="ORF">CaO19.8848</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="Microbiology" volume="146" first="869" last="876">
            <title>Candida albicans CFL1 encodes a functional ferric reductase activity that can rescue a Saccharomyces cerevisiae fre1 mutant.</title>
            <authorList>
                <person name="Hammacott J.E."/>
                <person name="Williams P.H."/>
                <person name="Cashmore A.M."/>
            </authorList>
            <dbReference type="PubMed" id="10784045"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Antimicrob. Chemother." volume="55" first="663" last="673">
            <title>Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans.</title>
            <authorList>
                <person name="Sigle H.C."/>
                <person name="Thewes S."/>
                <person name="Niewerth M."/>
                <person name="Korting H.C."/>
                <person name="Schafer-Korting M."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="15790671"/>
            <dbReference type="DOI" id="10.1093/jac/dki089"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="Antimicrob. Agents Chemother." volume="47" first="1805" last="1817">
            <title>Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors.</title>
            <authorList>
                <person name="Niewerth M."/>
                <person name="Kunze D."/>
                <person name="Seibold M."/>
                <person name="Schaller M."/>
                <person name="Korting H.C."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="12760852"/>
            <dbReference type="DOI" id="10.1128/AAC.47.6.1805-1817.2003"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2014" name="FEMS Yeast Res." volume="14" first="1037" last="1047">
            <title>A novel role of the ferric reductase Cfl1 in cell wall integrity, mitochondrial function, and invasion to host cells in Candida albicans.</title>
            <authorList>
                <person name="Yu Q."/>
                <person name="Dong Y."/>
                <person name="Xu N."/>
                <person name="Qian K."/>
                <person name="Chen Y."/>
                <person name="Zhang B."/>
                <person name="Xing L."/>
                <person name="Li M."/>
            </authorList>
            <dbReference type="PubMed" id="25130162"/>
            <dbReference type="DOI" id="10.1111/1567-1364.12194"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="2226" last="2236">
            <title>Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.</title>
            <authorList>
                <person name="Liu T.T."/>
                <person name="Lee R.E."/>
                <person name="Barker K.S."/>
                <person name="Lee R.E."/>
                <person name="Wei L."/>
                <person name="Homayouni R."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="15917516"/>
            <dbReference type="DOI" id="10.1128/AAC.49.6.2226-2236.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6 10">Ferric reductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). Involved in maintenance of cell wall integrity (CWI), mitochondrial function, and interaction between the pathogen and the host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6 7 8 9">Transcription is negatively regulated by SFU1, copper, amphotericin B, and caspofungin; and induced by ciclopirox olamine.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="10">Leads to abnormal cell wall composition, decreased ability of adhesion, and hypersensitivity to cell wall stresses. Increases mitochondrial activity and shows abnormal mitochondrial morphology. Also results in up-regulation of the expression of the cell wall integrity (CWI) genes PGA13 and CRH11, enhanded secretion, and decreased ability to invade HeLa cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716571.2">
        <property type="nucleotide sequence ID" value="XM_711478.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A446"/>
    <dbReference type="SMR" id="Q5A446"/>
    <dbReference type="FunCoup" id="Q5A446">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A446"/>
    <dbReference type="GlyCosmos" id="Q5A446">
        <property type="glycosylation" value="8 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_05770C_A-T">
        <property type="protein sequence ID" value="C4_05770C_A-T-p1"/>
        <property type="gene ID" value="C4_05770C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641810"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405770CA"/>
    <dbReference type="CGD" id="CAL0000193490">
        <property type="gene designation" value="CFL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05770C_A"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="InParanoid" id="Q5A446"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="PRO" id="PR:Q5A446"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044180">
        <property type="term" value="P:filamentous growth of a unicellular organism"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000046">
        <property type="entry name" value="Probable ferric reductase transmembrane component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
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    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
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    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
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    <keyword id="KW-0410">Iron transport</keyword>
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    <keyword id="KW-1133">Transmembrane helix</keyword>
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            <begin position="19"/>
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        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
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            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
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            <begin position="234"/>
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        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="425"/>
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            <begin position="431"/>
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        </location>
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        <location>
            <begin position="452"/>
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            <begin position="465"/>
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            <begin position="119"/>
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            <name>Fe</name>
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            <name>Fe</name>
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            <name>Fe</name>
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            <name>heme</name>
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            <name>Fe</name>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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            <position position="78"/>
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        <location>
            <position position="744"/>
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    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32791"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00716"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="10784045"/>
        </source>
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        <source>
            <dbReference type="PubMed" id="12760852"/>
        </source>
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        <source>
            <dbReference type="PubMed" id="15790671"/>
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        <source>
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        <source>
            <dbReference type="PubMed" id="25130162"/>
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        <source>
            <dbReference type="PubMed" id="10784045"/>
        </source>
    </evidence>
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    <sequence length="760" mass="84888" checksum="330AF6BC42AD23F1" modified="2017-03-15" version="2" precursor="true">MKIQQLIVFLFAVVLIDARTPKRYSELDIVMSTCTTFIGKYGTVCTSTGKRSTNWNCYCKTDAGFGTISDCLVRGFNNNTNIISKFTESCNMTESKFHAKYDKIQAEFKTNGTEYAKMTTKSSSGSKTSASASKSSKSTGSSNASKSSTNAHGSNSSTSSTSSSSSKSGKGNSGTSTTETITTPLLIDYKKFTPYKDAYQMSNNNFNLSINYGSGLLGYWAGILAIAIFANMIKKMFPSLTNYLSGSISNLFRKHLFLPATFRKKKAQEFSIGVYGFFDGLIPTRLETIIVVIFVVLTGLFSALHIHHVKDNPQYATKNAELGHLIADRTGILGTFLIPLLILFGGRNNFLQWLTGWDFATFIMYHRWISRVDVLLIIVHAITFSVSDKATGKYNTRMKRDFMIWGTVSTICGGFILFQAMLFFRRKCYEVFFLIHIVLVVFFVVGGYYHLESQGYGDFMWAAIAVWAFDRVVRLGRIFFFGARKATVSIKGDDTLKIEVPKPKYWKSVAGGHAFIHFLKPTLFLQSHPFTFTTTESNDKIVLYAKIKNGITSNIAKYLSPLPGNTATIRVLVEGPYGEPSSAGRNCKNVVFVAGGNGIPGIYSECVDLAKKSKNQSIKLIWIIRHWKSLSWFTEELEYLKKTNVQSTIYVTQPQDCSGLECFEHDVSFEKKSDEKDSVESSQYSLISNIKQGLSHVEFIEGRPDISTQVEQEVKQADGAIGFVTCGHPAMVDELRFAVTQNLNVSKHRVEYHEQLQTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A510</accession>
    <name>Q5A510_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ordered locus">CAALFM_C500530WA</name>
        <name evidence="5" type="ordered locus">orf19.8551</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_711682.1"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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            <begin position="1"/>
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            <end position="758"/>
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            <end position="688"/>
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            <end position="748"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AOW29496.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="89028" checksum="0CB0DD6832243EA4" modified="2005-04-26" version="1">MFPSIIITLFSIYQLIYSYNEHTINYYPPTELAISDEEIVNRAVQELHNIDAANDLNECMTCKTRLQVAKFISLTRPDLVPQIFSTWCVESGFDEIQCHMNYGYPSEDYCTMGNDFTKMVSLMNPSGLDGDYFCYYHDKNCGVLPETPLVDMSRLWPSKPRNYLPPDNSGETFHVLHISDINLQPDYKMFAEANCTQSLCCSPHCRNLQGSAPNFNENLEGGYFDSSYSRNHFEKGSYMDITKIKKPTWRPARQFGEYNCDSPALLLNSTMQGIRDLHQNHLSFEFALFTGGTVDHSDRSFMSKTKNIISQDTSYRILKHYLDTVDVIPTFGTRDIFPMNQLPQKHLTENSNSYQWQFDFLADLWLELGWIDHESSKQVRYSQIGYSLVTSRGLKIICLNSNVWNVKNLYAFWEVLSIDSFGMWKFLIEELIESERIHQRVWIVAHLPTNHQSLPLPTRVFAQIIERFSPQVIAAIFFGHIQVDTFMIQYGGDGTDTKELESAINHALVGPSISPYSGVNPAWRYYAIDSKSFSVVNSFTYYTKLDNTFINDGAEPVWEFGYSARDVYDPEQMWPMEWCLNTEWWHHVSEKIKQVPEMDLMYQRLDTRWFSQNELDGNSYCKVTSFTMEAKKQCMLTGDQDDYVEPKQPNDYVPFIHVGSKVEYIDKQVAYPPDEEEESESEEVDEDYQPGKKIGTGENNTNVGQGLNGGGNGESDDDNKVKKTEGFTGNENGEQNYTAANNDGSLSSRIRRKPQGKSLGLKIRNRHRIPIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A513</accession>
    <name>Q5A513_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UBC13</name>
        <name evidence="11" type="ordered locus">CAALFM_C500560WA</name>
        <name evidence="10" type="ordered locus">orf19.8548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="169" mass="19087" checksum="5F1E64148F5FD049" modified="2005-04-26" version="1">MAALPKRIIKETERLVSDPVPGIIATPSEDNLRYFEVTIIGPNQSPYAKGKFKLELYLPDDYPMCAPKVRFLTKIYHPNIDKLGRICLDVLKDNWSPALQIRTILLSIQALLGAPNPDDPLANDVAQDWKSDEKKAIEVAKEWTAKYAIDETEKTNDDKDESTTKESTQ</sequence>
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    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_711897.2"/>
    </dbReference>
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        <property type="gene designation" value="orf19.12635"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2061">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="PDCD2_C"/>
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        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
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            <end position="430"/>
        </location>
    </feature>
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        <location>
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            <end position="233"/>
        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="434" mass="48982" checksum="BA7070BA43A3CEE5" modified="2005-04-26" version="1">MSANDEYSSDEESFDESTKSKVLLGFVDAPIISDGKDPEDNDLPTIEDTFIGGQPVWLHPDSKPAEKSLTCDVCNGKLALYLQAFAPIDGKLYDRVIYVFGCKNTKSCSGKKGTVKVIRGIIKDSETVNRIKKENQEALQKDMEAKLKLEKQKKFNDELTKDLFKKKDTPEASNPFGGNSNPFSNPFGSNPFSKKPEEEKEEEKEKEKETSKSKSYADVASKNAPKPKSVKKLQDDLPEYRGLFVYVDNEKFKKIQHDPELEKYKHLIDKEEYDESDILEKPSSSASASGLDNPQASQISNMLNDKYFEMFSNTVKHNPGQVLRYDLGGKPLLYSGKDDVAKKFLAQPANIPRPSFNPSSERRFELQLMPKAIMDLEDLGNNRNVGINDILNGMSWGTIIVCTDEEDFIPEENFDANQVGYIEEWCGVQWEESV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6R1</accession>
    <name>RL15A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L15-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL15A</name>
        <name type="synonym">RPL15</name>
        <name type="synonym">RPL15B</name>
        <name type="ordered locus">CAALFM_CR04100CA</name>
        <name type="ordered locus">orf19.493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_712263.2"/>
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        <property type="resolution" value="2.67 A"/>
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    <dbReference type="SMR" id="Q5A6R1"/>
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        <property type="interactions" value="1367"/>
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    <dbReference type="STRING" id="237561.Q5A6R1"/>
    <dbReference type="EnsemblFungi" id="CR_04100C_A-T">
        <property type="protein sequence ID" value="CR_04100C_A-T-p1"/>
        <property type="gene ID" value="CR_04100C_A"/>
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    <dbReference type="GeneID" id="3641025"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04100CA"/>
    <dbReference type="CGD" id="CAL0000190553">
        <property type="gene designation" value="RPL15A"/>
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    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
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    <dbReference type="OMA" id="YIRDAWK"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
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        <property type="entry name" value="Ribosomal_eL15_CS"/>
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        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
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    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456530" description="Large ribosomal subunit protein eL15">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
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        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31148.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
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    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="204" mass="24329" checksum="D161964D98F6A8C4" modified="2005-04-26" version="1">MGAYKYLEELQRKKQSDVMRFLYRVRCWEYRQKNVIHRASRPSRPDKARRLGYKAKQGFVIYRIRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQKSLRSTAEERVGRRASNLRVLNSYWVNQDSTYKYFEVILVDPSHKAIRRDARYNWIVNPVHKHREARGLTSAGKKSRGINKGHLFNKTKAGRRHTWKKHNTLSLWRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A879</accession>
    <name>Q5A879_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sphingosine N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LAG1</name>
        <name evidence="14" type="ordered locus">CAALFM_CR01060WA</name>
        <name evidence="13" type="ordered locus">orf19.10759</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_712847.1"/>
    </dbReference>
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        <property type="interactions" value="602"/>
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    <dbReference type="STRING" id="237561.Q5A879"/>
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    <dbReference type="KEGG" id="cal:CAALFM_CR01060WA"/>
    <dbReference type="CGD" id="CAL0000185837">
        <property type="gene designation" value="LAG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01060W_A"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:unidimensional cell growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
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        <property type="entry name" value="TLC-dom"/>
    </dbReference>
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</entry>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
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                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </location>
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        <source>
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        <source>
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        </source>
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</entry>
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        <submittedName>
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        </submittedName>
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        <name evidence="10" type="ordered locus">CAALFM_C100490CA</name>
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    </gene>
    <organism evidence="10 11">
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
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        </reaction>
    </comment>
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        <reaction evidence="1">
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        </reaction>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000190988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW25747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="119" mass="13124" checksum="3EB431493A46565C" modified="2005-04-26" version="1">MFRTLLTKRLFNTSTMVSSQVKNKVEQLIKTKPVFIASKSYCPYCKATKSTIEAITKDAYILELDEVDDGAEIQEALLEITGQRTVPNVFIGGQHIGGNSDVQALKSSDKLDDKIKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADT7</accession>
    <name>Q5ADT7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C307370WA</name>
        <name evidence="2" type="ordered locus">orf19.14046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719851.1">
        <property type="nucleotide sequence ID" value="XM_714758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADT7"/>
    <dbReference type="GeneID" id="3638474"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307370WA"/>
    <dbReference type="CGD" id="CAL0000177348">
        <property type="gene designation" value="orf19.14046"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07370W_A"/>
    <dbReference type="eggNOG" id="ENOG502T156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1408556_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADT7"/>
    <dbReference type="OMA" id="GDENQHY"/>
    <dbReference type="OrthoDB" id="4013061at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000177348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="193" mass="21693" checksum="9C83C0010B4DEBFB" modified="2005-04-26" version="1">MSSSPKDILPLTHRPFGDENQHYVDHPEPELLATSVGKEVDGRLIPSSSTISLLSLNQSPSLRNSTTTSYTNLQHLQRMQPYHNQKVTTSPADYTHSFSTSRFIPIQQQPTPDSPNLAPISLGSSPSRFWLSSPPKSMNRIGDEPVIRPVQTPLEEPPMTPLYLNRPNVTRSDYFSRVSTVSEEEERRSMGHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADX2</accession>
    <accession>A0A1D8PKU8</accession>
    <name>HIR3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HIR3</name>
        <name type="ordered locus">CAALFM_C307680WA</name>
        <name type="ORF">CaO19.14011</name>
        <name type="ORF">CaO19.6719</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330892.1">
        <property type="nucleotide sequence ID" value="XM_019475347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADX2"/>
    <dbReference type="SMR" id="Q5ADX2"/>
    <dbReference type="FunCoup" id="Q5ADX2">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADX2"/>
    <dbReference type="EnsemblFungi" id="C3_07680W_A-T">
        <property type="protein sequence ID" value="C3_07680W_A-T-p1"/>
        <property type="gene ID" value="C3_07680W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638459"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307680WA"/>
    <dbReference type="CGD" id="CAL0000198181">
        <property type="gene designation" value="HIR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07680W_A"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001316_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ADX2"/>
    <dbReference type="OMA" id="WETWYRL"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="PRO" id="PR:Q5ADX2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090033">
        <property type="term" value="P:positive regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000256196" description="Histone transcription regulator 3 homolog">
        <location>
            <begin position="1"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1569"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1591" mass="182911" checksum="378BC914C8A3093B" modified="2017-05-10" version="2">MSSFIPLNFLEDTVSKKDLEEEHTRELQVEQAYKLFQSALKLQKQKQYESAYKVYEELFKLDIVSNHYFEELDFIRGLQDGSQNTDTDELTLLSPNVKSLRYLIFRNRGFLYLDMLKSNTENKSAEKVKEMFYPLLDDFCIALLYNEPDEKLLETLHEIFSYIGSERLSRFVLEYSLTSRKESDDLSGLLPIDQTVLSQYKTMLEHLSSGKFPKLDLKHLSFLEPIRLDIFAQQEKLASKKVAVIKSTSTKWVDLLDAINIHLKENQDESKIEDANRPRIRIFEPYVLTEEPLDIVRIEFTKRGVAVPATETEVTKAQPEQIVQERKPEEDNRVQRSSKRLSKVEDEIPAVTLESSHFLNMDYFRNQMNETIPNFEIFDVCSTYVEDGSGAQYIKDFKNIVSDWNDSYARAILSYDTAKSEDDNLKLLDLLSGYGKSEELKEKNIPPLGEIDIEFPELNYVEFKTYIIKHLLSKILTTKWSDKLYEKFTEWIVQFEGYIINDIDVESAIGVLEVLVDISTSLESQIKDSINNKLNKAVVNSMCQDLLRIKDKIIRWINYIETFPINDLQVASRFKWCQIIKEKAETKSWTENHPVKHKLQKLLGDAHFKINYPNYKNFIDFSKDSINSQLTIISVLAIFWRILSTSSTEDNKEAIRLLEDILLDSNTEPSDAILSIRNFLKQGSIDMKLSLWNILLSFYQSSNSGDKLTVGFEECVLFLNDYLVNEYVLLDEESRLVTLSRILGFYGSSISFVVTSLASTNWILMHPIKVQTLRLFFELSLLFEINEEASYISSLATSIKSKSTKSYHHLTNTLIKTIILILASIQKSNPQILHSVIRLFHTQLGLIGICGHAGGSFLEIAQEYLKSLPNSDQDICQIIKCKYHYSISIDGVVPADHGTARLDELNKNDCKELASFVLPLCFSKGGSTLNNVPKHDIKLLIDEIYDVIGDPDFDSNEALGRNKATLNYFLDNTRLTKRLFQEAFHGLVRLELGEAEEDKQFNGLYYIEGLLLFSSYKLRKKNMQSRAVELESAISLFENDIICGSNRFESWFLLGQSYGYLVEDDLIWTADKLTASDRKITTANLQRKSLICYLMAINKSLDESIKDVIKPVVGNLMSLFAKEMFSAVCEPMSMHAFKVQSHPRFINRVNGALFEPVSQFPAVDKTVCLKIIQQSLQLSIKSSCREWSDYYYLAKVQRKLDKPAGLVMETMASACRSAFKNKHADNIIEPHYNLVSFALKYVKSNRLDSKDALKYLIEDPLIKLEVGEETDFIKLIIKALNKIDSSDKKNWQHKAKYRLARLMQEEYHDVKGAIDQMSSFISLKTPNKALVSIWKPEPERPGKHFLYTFQYIHFYIELLKEIDDLDSLVAMLPKLRRSNSVMINLSIAWEILCSSVCKIIRESYGIGDNFEFTENLINTLPYQTFAANVKLLPDMMRRQSVPENLKSVLCFLFTVNDIKKLNNGYGPTSFIDDTLVTLYFMIYLNYFEKSSTEVTTDSPGLKKKIAKRDIFPLTNDILKAFKKDIEDVTKQKSYNELITAQKLKQGLNEDKSLENVPASANVNEIIVIDDDDDDNLSQEPATKKSKTESNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFB1</accession>
    <name>Q5AFB1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C402960WA</name>
        <name evidence="12" type="ordered locus">orf19.10212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720450.1">
        <property type="nucleotide sequence ID" value="XM_715357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFB1"/>
    <dbReference type="SMR" id="Q5AFB1"/>
    <dbReference type="FunCoup" id="Q5AFB1">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFB1"/>
    <dbReference type="GeneID" id="3637873"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402960WA"/>
    <dbReference type="CGD" id="CAL0000189170">
        <property type="gene designation" value="orf19.10212"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02960W_A"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000684_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AFB1"/>
    <dbReference type="OMA" id="GEASYMC"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000189170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1898" mass="219227" checksum="2BC9FA5CE59A3247" modified="2005-04-26" version="1">METDEENKLLKKFLLQLPIKADFDFNKNVKKEIRKALFMSISSNGEYLNWLFPSAFLDNQSYQRDDMIKKVEDDYEWTFNNYYKALLSKRDPKHDTHSHRAYHKNSPCGRIFRKGEPIHRCLTCGFDDTCALCSHCFQPEYHEGHKVHIGICQRENGGVCDCGDPEAWTQELFCPYAVDEDSTPVHDKEIPEKLAASILTTIAIILDYMIDVIIHSDLQFKNPEETTVHAIELNTANSTLDPRKYGCHDNEFVDATNNQYYLMLYNDQVRYYRDAVQRVHLASKKVKDFAIMVTDKVQKFGKAKVISSRNIPLLLERQKILSATGLATCIRSHRDIFREDMCDELVSWLNDFSESELFKTNAAVKDLFCRAFCEKWENGLLGVSEIETNYSYKVGTLDSSLRIPKIPSREQNTDGHWYYSPSKWKLCDELCQECNYNINTSEFQKNVSHHGSRLQYLVYLDIRLWKDTRALLHDMYSTSLIINLRYKNIICYQYVDIYPTIVDMYLTMDREPELSIMPTLSTQLFTCPTNSAEIIKHGDLTQILSSVYGFLTAERVTAPGDIDRTHQVSIKSLKNRRWGQIFFDLSYILTRSKNSKFLPNSNIVPMTCDMLVLFQGKPILKREKANHVEYESPDYSAFFQAVSVIYQFGEVIAGALKTTRETELCDILHNYQLAIEYVLTFLVNFENRNFPGLVDEEVDIKLSEEKAYNVEPITGSLIQISDIEEDKVSFLHPVHSFLSWLIEFSRFTDIRNLVEVFQTVKLKHIGSETPSLEVLIFDYPIKTIVLMSQIKAGLWVRNGFSVKSQLQLYKNTSLRDQGYTRDLFLIQVFANLDHPDVITYLILDRWKLLEDWLQNKPSHMYDIKTLPYMLEECLGFFIHLLTEDTHLRGYDEETLIKIKIQREIIHILCFGPLGYSKLCSQIPDHIVADRRFELILKSMTVFKAPKGSNDFGVYYLKDEYLDDVTPYYCHYTANVKDEAIKFVKERISKKKSKPVSDVIIEPKRIKTEELGIYKHVGNFATSTYFTNFLIKVLLFVNSCDTKVVESLLETILHLIHICSLEQTINIDKYGSFFDRFMNWSEEFGASIADLLYKILLAEEFKFSHTKIRSIFKIFNQKYPSFIPTLKARRSEFDISKVDLSSDDANSEDELGKKKRIAKERQAKLMAKFKKQQSSFLKKNQFETIACGSDTEMEELDDHAAWKFPEHHCMLCQNAAEDAGPFGIIAYISKSCEFRNVPFSDEYWFLKAFSDNVDLNGNEYESDINQSLHNSPHTQTWNSFMQQASNSSVIGPGFKLNEFIESHFVASSCGHGMHYQCYVNYISNSRNRQNQITRSTPENMDRKEFLCPLCKALNNIFVPILWSSNNRSLQEFLKPYAGTSPFLDLDMKIAKDRGWTERFQSFSEQEFDSRSILTGISKEMISMDSTKELTKQQRDFRLMLSDMFQTLTLFTFPQVFKADSGFVLIDTIKSIEISLRGVSSGGQLIIHQLSNNILLTLRTLNEFKNSSTLMKVKNWIDSPNLRKSAYSKIFAYIFALSKKSINNYMLEVDFFEHLVNTDTFPSLGFSFNSVLETCFIGHLIQSLSIMVNEMSANCLKKNWAYTVSDIPTIADIPQGISEAAISCFKKLSNSNDVRCIGNDESRKFGEVIYSMLVKIATPFLRRAAIYAYVQCANIDGIDFAASPETEIEADRLCSFLNLKPVCEYLRLFNEESSYEGSVFYDFLTFSSALPKANDVLRIKKQVEYPGIVKLVDLPERLDFFFTKYYYSDRHNNPNKKVEDPAICLFCGDVVDIQKQAIGCKEGQCTTHYLKECSNDVGIFLLPKDRSLLLLHKNGGTFYNAPFLDEHGEIAEESKKAKALHLMKPRYDDFIRNIWLSHNVQNCIVRSLESVLDPGGWETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFB4</accession>
    <name>Q5AFB4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gst2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">GST2</name>
        <name evidence="6" type="ordered locus">CAALFM_C402990CA</name>
        <name evidence="5" type="ordered locus">orf19.10208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720446.1">
        <property type="nucleotide sequence ID" value="XM_715353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFB4"/>
    <dbReference type="SMR" id="Q5AFB4"/>
    <dbReference type="STRING" id="237561.Q5AFB4"/>
    <dbReference type="GeneID" id="3637937"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402990CA"/>
    <dbReference type="CGD" id="CAL0000188890">
        <property type="gene designation" value="GST2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02990C_A"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="InParanoid" id="Q5AFB4"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000114">
        <property type="entry name" value="Glutathione S-transferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000188890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW29064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="219" mass="25261" checksum="6BE2DD40753181C1" modified="2005-04-26" version="1">MTKPIQFYTYGTPNGFKVSIFLEVLGLAYETISVDITKNESKSDWFVKLNPNGRIPTIVDPNFKDGEITISQTGAILQYLADNYDKEHKYSYAFGTEEYYKTLEYLIFQVSENGPIQGQLNHFKLFAKEKIEYGITRYENDTKRIYGVYEDILKRNSANDSKYLVGDRYTVADYALFGWAYSLHKVGIDIHDWPLLGKWFDALNKDPAVIKGVNVPEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFV3</accession>
    <accession>A0A1D8PLM6</accession>
    <accession>Q5AF67</accession>
    <accession>Q5AF68</accession>
    <name>SLX4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SLX4</name>
        <name type="ordered locus">CAALFM_C402590CA</name>
        <name type="ORF">CaO19.10255/10254</name>
        <name type="ORF">CaO19.2740</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720490.2">
        <property type="nucleotide sequence ID" value="XM_715397.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFV3"/>
    <dbReference type="SMR" id="Q5AFV3"/>
    <dbReference type="BioGRID" id="1221007">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AFV3">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C4_02590C_A-T">
        <property type="protein sequence ID" value="C4_02590C_A-T-p1"/>
        <property type="gene ID" value="C4_02590C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3637913"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402590CA"/>
    <dbReference type="CGD" id="CAL0000175447">
        <property type="gene designation" value="SLX4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02590C_A"/>
    <dbReference type="eggNOG" id="ENOG502RS18">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429039_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AFV3"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="PRO" id="PR:Q5AFV3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388020" description="Structure-specific endonuclease subunit SLX4">
        <location>
            <begin position="1"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="776" mass="87934" checksum="C9707C7B76F377D7" modified="2017-05-10" version="2">MATEYGDDDGGLYFHSTQMQSIHESLQQEENQRLYLQTSIKKLESFKHVNNDSSNNSNSGAVSVVQIKKKAATKKRKLMARKPNVKKPKSSSEAVRQAFEKDKFAYFTNNQAKIDDFLPGKSTSTEPSTSNQGSLISSDEWNYIKQIYLQKPTKNKTTLKSIRKRIKQYENSGTGMWEIAALNVDVSLNDEDIQHLYALDEEQMVSDDNSSTEDDTDPTQNDGLILTLSQNCSTQRDICHHEKDDQKYILIDSSICETYQQDKSLQRHSQKDSDNGNTIPDQNSAITIGEMESTAAHEVEEIFSTPSYVPSNKLNADQDRSDESESSIIMLADNIVSTQPDIVESISDSESEIEIIERPRLQVLRSVYENGTSTNQTRQELTMPKCLENNKISENEEYESEVVESDSTPIITPVVTPTKKPHIFPTNEPAIPIALRSTPNKIKNNVDRIFGSPSPIKLVLESPLKKHINIEFSDSESIYSTAVSQFGTPKQTTSFSPEVLTQKVGSPPLDACSDSGPTGVVSSMPYKKPHSTKRLRTTTLEISAALRVKNYTDPKNNITVKKFGEEIKREFIDLDNEIPDSESSDDDTGFSIIEITRQVEECKEPANDDYSEEQSTDLFQIGLKNKQETGNTSHMQVPSSPELQFENAGNTFLNSSLVEEDEFTKLKATELRERFKDWGLKPVQRKDKMLEILQGISDFISPESLLALKGFDLQQCVFDKLELLIKQDQFWYDRILTFEPIRLEELKQWLNSHNHHLELDILRLYCDRNCITTTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH01</accession>
    <accession>Q3MPF9</accession>
    <name>Q5AH01_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIND complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NSL1</name>
        <name evidence="3" type="ordered locus">CAALFM_C701830WA</name>
        <name evidence="2" type="ordered locus">orf19.13890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721375.1">
        <property type="nucleotide sequence ID" value="XM_716282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH01"/>
    <dbReference type="SMR" id="Q5AH01"/>
    <dbReference type="FunCoup" id="Q5AH01">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AH01"/>
    <dbReference type="GeneID" id="3637053"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701830WA"/>
    <dbReference type="CGD" id="CAL0000181763">
        <property type="gene designation" value="NSL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01830W_A"/>
    <dbReference type="eggNOG" id="ENOG502SA1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100671_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AH01"/>
    <dbReference type="OMA" id="QEWEDQT"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000181763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="230" mass="27094" checksum="2D2CEE88B43037E7" modified="2005-04-26" version="1">MDFQSDYEKIDLSKQDFQYVFNNILQAIMAKLNLHLPAAQNDPLKEQVSTILEEFLINTFDNSKYSILADGLDLQNVSIHDILSLKTLENVEKIDSEITIQLRKIFQEFEQETVDVTKLRRDLPKQASEMYNDIIKQTDGEVSEIINMIEQQSQEYQKVQQAHNNTDDRFEKIIESMDFSQINQNYNDHLQLLNETNKNLPSLKIEFEKYNRTVQFLEDAYQQQLKEMDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH60</accession>
    <accession>A0A1D8PR35</accession>
    <accession>Q3MPB0</accession>
    <name>TRM82_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transfer RNA methyltransferase 82</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM82</name>
        <name type="ordered locus">CAALFM_C702340CA</name>
        <name type="ORF">CaJ7.0274</name>
        <name type="ORF">CaO19.13831</name>
        <name type="ORF">CaO19.6477</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with the catalytic subunit TRM8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="BAE44750" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44750.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721318.2">
        <property type="nucleotide sequence ID" value="XM_716225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH60"/>
    <dbReference type="SMR" id="Q5AH60"/>
    <dbReference type="FunCoup" id="Q5AH60">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AH60"/>
    <dbReference type="EnsemblFungi" id="C7_02340C_A-T">
        <property type="protein sequence ID" value="C7_02340C_A-T-p1"/>
        <property type="gene ID" value="C7_02340C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636933"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702340CA"/>
    <dbReference type="CGD" id="CAL0000187643">
        <property type="gene designation" value="orf19.13831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02340C_A"/>
    <dbReference type="eggNOG" id="KOG3914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022082_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AH60"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002281">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000370516" description="tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="170"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAE44750." evidence="2" ref="1">
        <original>E</original>
        <variation>D</variation>
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAE44750." evidence="2" ref="1">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="426" mass="49087" checksum="46A6E513ABA8B920" modified="2017-05-10" version="3">MKHPFQILITNKKGTHIFAIVKNYLQVFDISKGGGDDDIKVGEWQDTTESNHPKIQIEKRTGRQISTQQIHNHLRYLILTPDEQHIIASTDSDKSILIFKIDFNNSINCLKLIKRQPIPKRPSSITIDSQGQRAIVADKFGDVYTVSINDDSSMSEIEIEIEKDIQPILGHVSMLTDITMATTHHNNNNNNNNNNNNKQFIITADRDEHIRISNYPKSYVIKNFLFGHDEFVSQLYIPVQYDPSILISGGGDDFINIWKWYEGELIETIQLRQYIESYLSDDHLPPTRFRTETSPKEISIAKIATLRTNDEEEEEDHLLIVLVENTPVLLVFNLDDSYKAKYLQAIIVNDSIIDFAIAADNKTIITSLESEQHSIKYFTLQEENDGKKFSEIQGPNIEQFIPIEVEQKSDFQQLYTIFQLRKRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK03</accession>
    <name>Q5AK03_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C505240CA</name>
        <name evidence="1" type="ordered locus">orf19.11500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721925.1">
        <property type="nucleotide sequence ID" value="XM_716832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK03"/>
    <dbReference type="GeneID" id="3636471"/>
    <dbReference type="KEGG" id="cal:CAALFM_C505240CA"/>
    <dbReference type="CGD" id="CAL0000192843">
        <property type="gene designation" value="orf19.11500"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_05240C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787549_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AK03"/>
    <dbReference type="OMA" id="PCTCHCH"/>
    <dbReference type="OrthoDB" id="4015084at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000192843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="314" mass="35791" checksum="CE637E8DC77BC569" modified="2005-04-26" version="1">MESISHKYRDLKFRVNHLLVAYRQRYYSTHKNPRVIQSRVQNQQLLSLRTFPKDPYLTGSDKPFLHLSKEYEETESQYLDNSDERDYTLFEYTNDMSSKAHDSATHGKSYSEPNFGEGYFSTFRLELPTNPSSDEQHQEITQFDPTQPAEQCEPLLDMSITTDEYLSGSSISPVSFPCTCHCHTFEKIAPQSSTNKRNHNVKEKLYDFVVNNFSKVTGQGNDTVATISSNIETFTPLDIQATDSIETVPDKTDPTKGTDRIWKLVLNDVSLSAARLSTGSSNIPVVNNQNIRGDFINAKVKTITNNENEDIFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK49</accession>
    <name>Q5AK49_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C504850WA</name>
        <name evidence="2" type="ordered locus">orf19.11454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721880.1">
        <property type="nucleotide sequence ID" value="XM_716787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK49"/>
    <dbReference type="GeneID" id="3636436"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504850WA"/>
    <dbReference type="CGD" id="CAL0000199927">
        <property type="gene designation" value="orf19.11454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04850W_A"/>
    <dbReference type="eggNOG" id="ENOG502T5D6">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5AK49"/>
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        <property type="component" value="Chromosome 5"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="252" mass="28758" checksum="DFB51AC1C461B4F1" modified="2005-04-26" version="1">MTNIIIDHQSTFTAYILALSIYFKYLHLRNLKIMIIENEISQSLDTKPWCGISTLNNFKLSNQDFINYLIQFTITLGSISIRPVSPNPDTPIKEIMNTTIDSRNYVGLLYHPIDLMNKIRFAMFRSGRVSFVSPNVNFNQPGPLHQNLSGIRVVTTTAMRNSHNINSFIYHSNMIGTRCRNGNLPSQILWLPKFSSDNHINCTTTNNSQIMLDLSIEPYAYIDLSYALKQCDMILDTIDKLMGSSIPLSNRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AM50</accession>
    <accession>A0A1D8PGI4</accession>
    <accession>Q5ALQ0</accession>
    <name>NMD4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Nonsense-mediated decay protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NMD4</name>
        <name type="ordered locus">CAALFM_C202090WA</name>
        <name type="ORF">CaO19.1525</name>
        <name type="ORF">CaO19.9101</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nonsense-mediated decay of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722569.1">
        <property type="nucleotide sequence ID" value="XM_717476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AM50"/>
    <dbReference type="SMR" id="Q5AM50"/>
    <dbReference type="FunCoup" id="Q5AM50">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AM50"/>
    <dbReference type="EnsemblFungi" id="C2_02090W_A-T">
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        <property type="gene ID" value="C2_02090W_A"/>
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    <dbReference type="GeneID" id="3635854"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202090WA"/>
    <dbReference type="CGD" id="CAL0000184115">
        <property type="gene designation" value="orf19.9101"/>
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    <dbReference type="eggNOG" id="ENOG502S5VM">
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="398" mass="46338" checksum="CA4C71EF1B9E154A" modified="2005-04-26" version="1">MSLELSSNESEDNFRDELVDISGQVSKKPINIDSRQVRLILDHTAFVRGIGNIKRWFNEEYINSNTTRSNEIINLNIYIPTYTLHEFDFVKKGTSISATNAREAIRFIDNYLENEVEMNSDKIQYNLILESPQDNVPSWNKCNHYKVHSPKIKEFPNYKTKFDSSLIGQTPNVNEDSEFNENFDNALTFNQRNKLNDIQYENSASYQNAIANSDNLAEMPVRLRYLIRSCIYKRFIETKKPKIKNEIEDWKLVTEDPITKIWAKSYGIDCLNVNEAELLIFQNYDVNSFRLYNPYANDGDDFDPSTNILQNTIDTTLYSYSSVQDEPVTSNYRGKNNRGRNNRGRRGNKRRERERWPLSTDAVVSEERNESGTGFIKKEKFGAINYAPRGQGELWRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMP4</accession>
    <name>Q5AMP4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">MDH1-1</name>
        <name evidence="16" type="ordered locus">CAALFM_C401900CA</name>
        <name evidence="15" type="ordered locus">orf19.12072</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722674.1">
        <property type="nucleotide sequence ID" value="XM_717581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMP4"/>
    <dbReference type="SMR" id="Q5AMP4"/>
    <dbReference type="FunCoup" id="Q5AMP4">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AMP4"/>
    <dbReference type="GeneID" id="3635636"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401900CA"/>
    <dbReference type="CGD" id="CAL0000181799">
        <property type="gene designation" value="MDH1-1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C4_01900C_A"/>
    <dbReference type="eggNOG" id="KOG1494">
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    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AMP4"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
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        <property type="entry name" value="Lactate/malate_DH_N"/>
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        <property type="entry name" value="Malate_DH_AS"/>
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        <property type="entry name" value="Malate_DH_type1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
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        <property type="entry name" value="Ldh_1_N"/>
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    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="162"/>
            <end position="328"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="24"/>
            <end position="30"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="50"/>
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            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="96"/>
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        <ligand>
            <name>substrate</name>
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            <position position="102"/>
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        <ligand>
            <name>substrate</name>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="134"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
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        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000181799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW28961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="332" mass="34728" checksum="939B7EB71311519A" modified="2005-04-26" version="1">MFSKVATRSFSSSASNAYKVAVLGAGGGIGQPLSLLLKLNHKVTDLALYDIRGAPGVAADVSHVPTNSTVKGYNPDQIEEALTGSDVIVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAADYAPNAAVCIISNPVNSTVPIVAEVFKSKGNYNPNKLFGVTTLDVLRAARFVSEVAGTNPVNENVPVVGGHSGVTIVPLLSQTKHKDLSGETRDALVHRIQFGGDEVVQAKDGAGSATLSMAQAGARFAGAVLDGLAGEKDVIECTFVDSPLFKDEGVDFFSTKVTLGVDGVKTVHPIGEISDYEEAQVKEAKDTLIKNIKKGVDFVAQNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2025-06-18" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANB2</accession>
    <accession>A0A1D8PK49</accession>
    <name>DBP10_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP10</name>
        <name type="ordered locus">CAALFM_C305160CA</name>
        <name type="ORF">CaO19.13412</name>
        <name type="ORF">CaO19.5991</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723201.1">
        <property type="nucleotide sequence ID" value="XM_718108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANB2"/>
    <dbReference type="SMR" id="Q5ANB2"/>
    <dbReference type="FunCoup" id="Q5ANB2">
        <property type="interactions" value="1136"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANB2"/>
    <dbReference type="EnsemblFungi" id="C3_05160C_A-T">
        <property type="protein sequence ID" value="C3_05160C_A-T-p1"/>
        <property type="gene ID" value="C3_05160C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635229"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305160CA"/>
    <dbReference type="CGD" id="CAL0000186628">
        <property type="gene designation" value="orf19.13412"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05160C_A"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_1_1"/>
    <dbReference type="InParanoid" id="Q5ANB2"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="PRO" id="PR:Q5ANB2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232311" description="ATP-dependent RNA helicase DBP10">
        <location>
            <begin position="1"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="130"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="373"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="821"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="908" mass="103561" checksum="CA20D4A7D93C712C" modified="2005-04-26" version="1">MSDDEAFDIAGSLALKDEDDYSDSSSNEGEDFQDEIIPSDDEKEPSPPPKKKSKPNPQAFPSLELSDNEGNNDDDDDDDSKINSYFINNNPTAKKAKAGSFASFGLTKFILANIAKKGYKQPTPIQRKTIPLIMEGRDVVGMARTGSGKTAAFVLPLIERLKSRQPGGVRAVILSPSRELALQTYKQVKEFSHGTNLQSIVLIGGDSLEEDFSKMMTKPDIIVCTPGRFLHLKVEMQYDLMTVQYIVFDEADRLFEMGFAEQLNELLASLPSNRQSLLFSATLPRSLVDFAKAGLTNPVLVRLDAESKISDQLQMAYFTTKKNEREANLLYILQEVIKMPLGSEEQIKKLKDMDKRKIDSDSEDDDDDEERKKGKKRYKFKKERLPPANRLPSPHSTIVFVPTKHHVEYVTKLLRDAGYLVSYIYGTLDQHARKNQLYQFRVGLTNVLVVTDVAARGIDIPVLANVINFTLPASSKIFIHRVGRTARAGNKGWAYSIVNEKELPYLLDLELFLGKKILLTSMHEAKVEMLKKSSTGTFIPPVVNYTERLVLGSVPRVDLETFQELYENLLRNNYEIKVLKDVAAKGEKLYHRTRQPASQESLKRSKEIIESSWDDQHLLFGENLEKQKDAFLAKLQDRNSKQTVFELKGSDESLVEFMNRRRRQLAPIQRKAKERKELLAKERLAGLTHGIEDEILRADGENGYGVDEDELQEAFEDADKKKSFRDPQFFLSHYAPASVIQDQQLSLSTSFANEAQAATFDLDNDDKIQTNKQVMRWDKKKGKYINSKSTDKKYIISENGTKIPASFRSGKFDEWRKQRNLKPTSTVEDDSNKRFKHKQQRAPKLPDKFRDDYHKQKKKVEKAIESGVNVKGFHTPQQEIKSTEQIRKARLLKEKRKAKNARPSKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANH1</accession>
    <name>Q5ANH1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium permeable stress-gated cation channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C304720CA</name>
        <name evidence="12" type="ordered locus">orf19.13353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723144.1">
        <property type="nucleotide sequence ID" value="XM_718051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANH1"/>
    <dbReference type="SMR" id="Q5ANH1"/>
    <dbReference type="FunCoup" id="Q5ANH1">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANH1"/>
    <dbReference type="GeneID" id="3635249"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304720CA"/>
    <dbReference type="CGD" id="CAL0000197794">
        <property type="gene designation" value="orf19.13353"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04720C_A"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_0_2_1"/>
    <dbReference type="InParanoid" id="Q5ANH1"/>
    <dbReference type="OMA" id="CSCKKEN"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="40"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="242"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="482"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000197794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="99415" checksum="0459386ADEB31530" modified="2005-04-26" version="1">MIDNIINNLQIILQQNDDNFTSPHDDVIYRPHSARVARYQVIIASTLGLTALLLFSILRLKYPKIYVANFNHLNFSLHSTSRRNLPELPSNSLFGWIPTVYKITEQEILEHAGLDAVVFLEFFKMCIRIISICLVFAIIIISPIRYKFTGRVDEDYPDDDSDNDDDDGSNNNGTTIIKHIVSAGISVASKNNDGEQYQQFLWLYTIFTYVFTFVTVYFLFKQTNRIISMRQKYLGSQNSVTDRTVKISGIPGSLRDEVALARHIDRLNIGEVDSVLIVKEWQNLNKLFKRRRRIVRKLEESWVEYFEKNGITNKSDLISLHPQVGESYRFSNRYTDDAEESPDWGSQNSNSAQASIIDQDSESVEGDSSDTLNRLLNDESRTRPSLRKGWFGLFGPKVDSINYYTDKLEVIDKEITRARTREYPATSTAFLTMKTVAEAQMLAQAVLDPKVNHLITNLAPAPHDIRWDNLSLTRQDRNTKILAVTIFIGIMSLLLVYPVRFMASFLNTKSISKIWPSLGKAIESHKWAETLITGLLPTYLFTILNIVIPFFYVWISEKQGYLSHSDEELSSVSKNFFYIFVNLFLVFTTFGTASFVDTTKIAFDLARSLRDLSMFYVDLIILQGLGIFPFKLLLVGNLLRFLVNSLFRCKTPRDYLNLYKPPVFNFGLQLPQPILIFIITLVYSVMSSKILTAGLLYFIIGYFVSKYQLLYACVHPPHSTGKVWPIIFRRIILGLFLFQITMVGTLALQDAITCATFLAPLPFLTLYFWWSFHKQYIPLSTFIALRAIESNENINPTDLEQIIENNNNKTLDERRELNTKYEYPNLVNDLDGPMIALDGEDVLIVNRDGTTVRKPPQYFSSEWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANP3</accession>
    <name>Q5ANP3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C304130WA</name>
        <name evidence="5" type="ordered locus">orf19.13279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="4 5" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="entry name" value="Ty3_capsid"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    <accession>A0A1D8PCB9</accession>
    <name>ERG2_CANAL</name>
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        <name evidence="5" type="primary">ERG2</name>
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            <taxon>Pichiomycetes</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Antimicrob. Agents Chemother." volume="48" first="1778" last="1787">
            <title>Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans.</title>
            <authorList>
                <person name="Mukhopadhyay K."/>
                <person name="Prasad T."/>
                <person name="Saini P."/>
                <person name="Pucadyil T.J."/>
                <person name="Chattopadhyay A."/>
                <person name="Prasad R."/>
            </authorList>
            <dbReference type="PubMed" id="15105135"/>
            <dbReference type="DOI" id="10.1128/aac.48.5.1778-1787.2004"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>fecosterol = episterol</text>
            <dbReference type="Rhea" id="RHEA:33435"/>
            <dbReference type="ChEBI" id="CHEBI:17038"/>
            <dbReference type="ChEBI" id="CHEBI:23929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:33436"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is repressed during biofilm formation.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Increases the susceptibility to 4-nitroquinoline oxide, terbinafine, o-phenanthroline, itraconazole, and ketoconazole (PubMed:15105135). Affects the proper surface localization of the drug transporter CDR1 (PubMed:15105135).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718988.2">
        <property type="nucleotide sequence ID" value="XM_713895.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCB9"/>
    <dbReference type="SMR" id="A0A1D8PCB9"/>
    <dbReference type="FunCoup" id="A0A1D8PCB9">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCB9"/>
    <dbReference type="EnsemblFungi" id="C1_00800C_A-T">
        <property type="protein sequence ID" value="C1_00800C_A-T-p1"/>
        <property type="gene ID" value="C1_00800C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639347"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100800CA"/>
    <dbReference type="CGD" id="CAL0000177093">
        <property type="gene designation" value="ERG2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00800C_A"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCB9"/>
    <dbReference type="OMA" id="AMYVIHA"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768">
        <property type="reaction ID" value="UER00761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000454178" description="C-8 sterol isomerase ERG2">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15105135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="15105135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW25777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="217" mass="24559" checksum="39EAF39FD7763F16" modified="2017-01-18" version="1">MKLLLVGIIPIALYAIFNYLFYTWLPTNYLFDKQVLQELVQETLKDHLDGNATAIMIDLTPKIQKKYPKIINDLNFDDWVYNNAGGAMGTMFILHASISEYLIFFGTAIGTEGHTGVHFADDYFTILTGEQRAAYPGALIPEVYLPGDQHHLPKGHVKQYAMPGESFALELAQGWIPAMLPFGFLDTLTSTMDFYTFYLTAYYTGKDMIKNLLIGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCD8</accession>
    <name>A0A1D8PCD8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TSC13</name>
        <name evidence="20" type="ordered locus">CAALFM_C101050CA</name>
        <name evidence="19" type="ordered locus">orf19.10803</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718116.1">
        <property type="nucleotide sequence ID" value="XM_713023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCD8"/>
    <dbReference type="SMR" id="A0A1D8PCD8"/>
    <dbReference type="FunCoup" id="A0A1D8PCD8">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCD8"/>
    <dbReference type="GeneID" id="3640170"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101050CA"/>
    <dbReference type="CGD" id="CAL0000194246">
        <property type="gene designation" value="TSC13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01050C_A"/>
    <dbReference type="eggNOG" id="KOG1639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCD8"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000038">
        <property type="term" value="P:very long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="153"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000194246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW25801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="312" mass="36182" checksum="0273A82C63F676E0" modified="2017-01-18" version="1">MTDIEVKSRSRSIKSFSSNELTPDSSVQELINELSSDNHISEHRLRLTKLENGKQVALIPHKTFAENGIPKTASKIELFVKDLGPQISWRTVFLVEYFGPFIFHPLFYYVQSLYGSGSFEHTQTQKFAFAIVLLHFLKRELETIFVHKFSNATMPAFNIFKNSGHYWILSGFNLAYFIYGPSDKSGVLKYFFHVNELPSSVVYGLFGLWVFAELSNLTTHLILSNLRKGDSKVYVIPFGYGFNWVSCPNYFFESLSWLAYALLVGNWSAWIFLFVSSGQMWLWAVKKHQRYLKSFGDDYKKLKRKIYIPFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCM0</accession>
    <name>A0A1D8PCM0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ESP1</name>
        <name evidence="8" type="ordered locus">CAALFM_C101670CA</name>
        <name evidence="7" type="ordered locus">orf19.10864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718179.2">
        <property type="nucleotide sequence ID" value="XM_713086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCM0"/>
    <dbReference type="SMR" id="A0A1D8PCM0"/>
    <dbReference type="FunCoup" id="A0A1D8PCM0">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCM0"/>
    <dbReference type="GeneID" id="3640197"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101670CA"/>
    <dbReference type="CGD" id="CAL0000192671">
        <property type="gene designation" value="ESP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01670C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PCM0"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032888">
        <property type="term" value="P:regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1308"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000192671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW25856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1598" mass="184250" checksum="64F6E0647F16CECE" modified="2017-01-18" version="1">MDNSLDQKLLAFISSQSSSKPLSPSKSNNLPKADIKSLESLCVTSLDTLLNNIGGSTTNNSILPLDSLDAIEVRLRGLYLIYADDPRKSFDILRKHQLYIVKLFNIKQIDYVYQNLNVLLAQINKVFKIEFTSKSTIFTGIEFTDFNNWNDDTSFFNVNRKDITQLIIAFHFLVLQWIAQYVSKNLKSILMQKNQFISLDEFCNIPQMFLNSSNFRKWQLLPSNENIGKYNTNNVKLISGFIKVFQSIKVSSSLSKYVGLTNCLKLKLYELTKDESLLESIGFSSNLIPFINDANININEFIRKHVPIESEGSNELQTRLLKSPQLVTDSDFLRNLQNDSQLSVDKCQIIISSFNGFKDNLKTLSNQQLSILDLITIHLKDSLDESVVPILSQSFQIYSHFKLMKRMRNISNLLFNLGNKVHNEIYRNLAIDYECAIFEISPNNDNFKQLYNKLTRTQVTGSVLGNVLQCFETYISLKNNKDDPINGTIIQFICKTLSQTSNFASLNNIKNENLKYDIVNDIFQFMEKSNNTAEKTKICNSIIESTSWCNQLIECKIYYQYYNVNGLEKYLDLEEKSCDNQLVTSGIQFQRLVTFGWNETLLVECLNNLKYGLNYNSSEFDLFELNIIKQVLLYIKYNGMIDELVDIIEISLAKSIKDEQFEKFLKFEYCRALLSQTNNNPTNDVKFSQIFLDLKKRSQNWKSFDDIIQLSLLQLQYCIYVKNSTKAKDRFNGILQTLLKKPQFNISKSKNLPIVSKLQNFLILGKFQLLACHVNNHIIHNKIEAFNNIKTGIQLLYSIVKKLPTNINKTLWQELNWEITRLLFDSYKLAIDLSIDIGISRDIPLFLNEWVKLNNSIDNDVPIVNCINEFEIGRYGLLSNNEFQKYIRIAQGRLGYSLVKNNSAVQQYINRDRDDEICGHASSSRQLKSLVRTIFNSDNSLSELSKSVQLLPCIIGDSSTMCSKELLDKLVQLKNEILTEVTNYEKSSSLSLNQQQQLINNLNQVVCLLSSLTLFKGDGLLSEIYYLQDYVRNLPFANERKLMDSSKQDESNNLLPHALDFNQVVEDPSNNTINNSMIDFNVDLQLYLPHNWILVTLDICQNTGDLLISKLTKGSPNPFFMRLPLSRFPSSLGFQQLMQNFEKIIDDSNLSTKRKTTSKILTVEDRKQWWRSRFTLDFQLQDILHHVESKWFGGFISGIFTNDNDVENESKNVFHKFKQDLMKILKDCLTVSDDKSNIERFLQFNEFIYYCFYSMEEYNYELVDDLIKFITINMNSHGRIVNFGTNVKINKLHELIKNLIDKVNKNKQNVTSNNKNNSNNNSNNNNNSNNNSNSNNSQHIVLIPNANCSNFPWESMEFLRSKSISRMPSIHMLLDLVKSNTNNKNKLMFVDKSNLYYLINPSGDLIRSENRFKKLFESNHLWRGEIGKLSSNEHEDYQDSILCEILKSHLFVYIGHGGCDQYIKVSKLFKKCGNNQDSSNKLPPSLLLGCSSVKLDNCNYNYNSSMLQPSGNIYNWLNCKSSMILGNLWDVTDKDIDIFTLSLLQKWGLIDDYNGSGHDYGMKKLDLTNCVVQSRSKCTLKYLNGSAPVVYGLPMYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCW3</accession>
    <name>A0A1D8PCW3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyoxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">GOR1</name>
        <name evidence="7" type="ordered locus">CAALFM_C102980WA</name>
        <name evidence="6" type="ordered locus">orf19.10506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721487.1">
        <property type="nucleotide sequence ID" value="XM_716394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCW3"/>
    <dbReference type="SMR" id="A0A1D8PCW3"/>
    <dbReference type="FunCoup" id="A0A1D8PCW3">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCW3"/>
    <dbReference type="GeneID" id="3636836"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102980WA"/>
    <dbReference type="CGD" id="CAL0000192040">
        <property type="gene designation" value="GOR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02980W_A"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCW3"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="24"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="124"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000192040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW25979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="342" mass="37825" checksum="4EF7FE009B86E863" modified="2017-01-18" version="1">MTTGTSKPKVLLVGEFIYSKQKWSELEEIAEVIQSESTTREQFIQDLKTKYNDITCIARTFYSINETGRFDADLAQHMPKTLKSVSHCGAGYDQVDVEPFTRLGVQVSNVTEPVERPTADVAVFLVLACMRNFLQGRQILMNGEWPSNGDKEAAGAPLGHTPQGKVVGILGMGGIGRAIRDRLKPFGFDGIVYYNRKQLSPELEKGAEYVTMDELFKQSDVIIIGVPLNAKTRHLIDKEAIQKMKDGVVLVNIARGAIIDEKHLPELIKSGKIGAFGADVFEHEPEVSAELVNLPNVVALPHMGTHSVEALTNMEEWVVCNVETFIKTGKLKTIVPEQQGIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDL6</accession>
    <name>RL7A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">60S ribosomal protein L7-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPL7A</name>
        <name type="ordered locus">orf19.2478.1</name>
        <name type="ORF">CAALFM_C105720WA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330654.1">
        <property type="nucleotide sequence ID" value="XM_019475109.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="BB/o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="BB/o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="BB/o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="BB/o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="o=1-241"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
    <dbReference type="PDBsum" id="7Q0R"/>
    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDL6"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PDL6"/>
    <dbReference type="FunCoup" id="A0A1D8PDL6">
        <property type="interactions" value="1452"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDL6"/>
    <dbReference type="EnsemblFungi" id="C1_05720W_A-T">
        <property type="protein sequence ID" value="C1_05720W_A-T-p1"/>
        <property type="gene ID" value="C1_05720W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515000"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105720WA"/>
    <dbReference type="CGD" id="CAL0000182421">
        <property type="gene designation" value="orf19.2478.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05720W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PDL6"/>
    <dbReference type="OMA" id="SYYVDAQ"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456492" description="Large ribosomal subunit protein uL30">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW26237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="241" mass="27399" checksum="AB54EE7D966E1ED3" modified="2017-01-18" version="1">MATTLKPETLQKKEKAQQKTAEERAAAKKVRKAANKEKRKVIFDRAAAYQKEYTEAERSVIKAKRDAKASNSYYVDAQPKLVFVVRIKGINKIPPKPRKVLQLLRLTQINAGVFVRLTKATSELIKLAEPYVAYGYPSLSTIRQLVYKRGFGKVNKQRIALSDNAIIEANLGKFNILSIEDLIHEIYTVGPNFKQVSNFLWPFKLSNPNGGFRARKFQHFIQGGDTGNREQFINALVKQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE34</accession>
    <name>A0A1D8PE34_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C107610CA</name>
        <name evidence="2" type="ordered locus">orf19.10300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000187987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW26934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="196" mass="20252" checksum="762D0BF356E6788C" modified="2017-01-18" version="1">MSVPSILATTALLTVGGYMLFTGAGESFNIGEFLESTSPYMWASLGIGSCIGFSVVGAAWGIFITGTSILGAGVKAPRITTKNLISIIFCEVVAIYGLIMAIVFSAKLTSVPSKSLYTKENLYTGYSLFWAGLTVGISNLICGIAVGITGSTAAISDAADSSLFVKILVVEIFGSVLGLFGLIVGLLMTGKAQEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG34</accession>
    <name>A0A1D8PG34_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sap30p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">SAP30</name>
        <name evidence="9" type="ordered locus">CAALFM_C200460WA</name>
        <name evidence="8" type="ordered locus">orf19.9629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PG34"/>
    <dbReference type="STRING" id="237561.A0A1D8PG34"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG1339">
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    </dbReference>
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    <dbReference type="OrthoDB" id="771136at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    </dbReference>
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        <property type="entry name" value="Aspartyl protease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
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    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111087" evidence="6">
        <location>
            <begin position="17"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="37"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000197549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="435" mass="47875" checksum="6217B7FB5EE011A1" modified="2017-01-18" version="1">MLFTILSLLVPSLAVAVSNTGGAVKLDLTISDEHMYYIENLALGTPPQFISNVIVDSGSSDLMIVDSIYNFSASSSLYNSNQTAIMKYGYGGQFPVYFINETIRSNDWKLSNLSVGLANISDMDSFSGILGIGFTRQELFKTNYSNFPYLLKDQGYTKSVLFSFNGQDQNPSIIFGGISTNIIDGPLVRAPFIKVISFINQLDYWLMPTFTVNQIKLGDTIVSNQKTLYQIDSGTNGFVPPTPVLNNILKILGDDYIQDDNGNIYFDIKYIEGLNITFSVQGYDIGFQLVDIVGDTIERNSTTFVALNVASCDIGYNAYEGLLPNLIFKYHYAIFDYDNAQIYFGKYKNSNGEANVVAVENGYQLPVPTVDVPDVEDTYSVIYIAESETTVTVAPTEVQSTYSSFSISEGTSSNLTSGSTSDDKITSVTSNPQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGP3</accession>
    <name>A0A1D8PGP3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC14 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">PDR17</name>
        <name evidence="8" type="ordered locus">CAALFM_C202680WA</name>
        <name evidence="7" type="ordered locus">orf19.13261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715379.2">
        <property type="nucleotide sequence ID" value="XM_710286.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGP3"/>
    <dbReference type="SMR" id="A0A1D8PGP3"/>
    <dbReference type="STRING" id="237561.A0A1D8PGP3"/>
    <dbReference type="GeneID" id="3643007"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202680WA"/>
    <dbReference type="CGD" id="CAL0000190551">
        <property type="gene designation" value="PDR17"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02680W_A"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGP3"/>
    <dbReference type="OMA" id="RPLFYMK"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901352">
        <property type="term" value="P:negative regulation of phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006658">
        <property type="term" value="P:phosphatidylserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001247">
        <property type="term" value="P:positive regulation of phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0492">Microsome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="161"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000190551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="364" mass="42204" checksum="2E4137B2623A2189" modified="2017-01-18" version="1">MNFFRKKTEEDRDSSSSSLPRDDTASVSSKATSTSTNTTSKVELVKCYIPFEQPVNPIKAPDFELDKEQIEKYEKLVAYFEDYISKEIPVNDQHNATTHPLIEDELAWLTKECFLRYLRATKWKVDAAIKRIEDTIIWRRTFGVANIPNHTDPKKLITADLVSDENETGKQLIVGYDNDNRPCLYLRNGYQNTAPSLKQVQHLVFMLERVIHFMPPGQDSLALLIDFKAAPAELNLSSKFPSLSTSKQCLHILQSHYPERLGRGLFTNIPWIGYTFFKVVGPFIDPHTRSKTIYDQPFENFVPKEQLDKEFNGILDFEYIHDTYWPKMNEIADRKRANYMENFRRLGSKIGLSEYDLRLEQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGS2</accession>
    <name>A0A1D8PGS2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">MET1</name>
        <name evidence="16" type="ordered locus">CAALFM_C202940WA</name>
        <name evidence="15" type="ordered locus">orf19.13233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715352.2">
        <property type="nucleotide sequence ID" value="XM_710259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGS2"/>
    <dbReference type="SMR" id="A0A1D8PGS2"/>
    <dbReference type="FunCoup" id="A0A1D8PGS2">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PGS2"/>
    <dbReference type="GeneID" id="3643014"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202940WA"/>
    <dbReference type="CGD" id="CAL0000185049">
        <property type="gene designation" value="MET1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02940W_A"/>
    <dbReference type="eggNOG" id="KOG1527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGS2"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="275"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000185049"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="561" mass="61491" checksum="2116D95BCD7464B5" modified="2017-01-18" version="1">MTNLLTSNITTGETHLLIGYSAVSNTRIVSIIESGANPILITDSQPQNFPPNIMQYVTDNKLPVLIDKDFPTKIPHYLTTLGRAEVDSIVDRVYVSLPSSQLALKQEIYQRCRKLRIPVNTTDSPDLCTFTMLSTYTSGDFQLGVTTNGKGCKLASRIKRELVNSLPSDIDAICKQVGELRRQIQMEDKAESEHGEHEDDAINNHKFNSFVPEFNKTQEDLKLQRARWLSQIVEYYPLNKLGSISLKDLSSAYKLHKQANVPGAKEEDSEAGQMTLVGSGPGSVSLLTLGALQAIQTADLVLADKLVPQQVLDVIPTTHHTRLFIARKFPGNAEKAQEELLTLGLEALRRGEKVVRLKQGDPYIFGRGGEEFNFFSQHGFKPTVVPGITSALAAPVLSNIPMTHRDVADQVLICTGTGRRGAVPNLPDFVSSRTTVFLMALHRVVELIPLLVNDKKWDENLPVAIVERASCPDQRVIRTTLSKVGDAVEACGSRPPGLLVTGYACEVICKNSGSESLPWVVEEGCNSGDDGELKRIVELVNGNCKESTAVVSPNLQKEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH80</accession>
    <name>A0A1D8PH80_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">RPB4</name>
        <name evidence="7" type="ordered locus">CAALFM_C204650CA</name>
        <name evidence="6" type="ordered locus">orf19.7785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_705505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH80"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C204650CA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="147"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000176099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="268" mass="29969" checksum="6B6ED382DD4F9BE3" modified="2017-01-18" version="1">MNVSTSALGVRRRKVTTQNIDDEENSAVLKLGPEFQLNQITNDGEEQQLIALNLSEARLLIRAALKERKHNKNKNKTRKKGGNNNNSSSISNSGNKNRLNGNHNTNVGDINGGDGDSNIDGNNISNNNDKDINGDRQNKGNNDDNDDDDDDDDDDDDEDEEDMKEDEISNMELAGPNSNEIVHKTLNFLTNFARFKNRSSCETVEKLLNDFSEHCNEPLHPFELAQLGTLECEDPEEAKSLIPSLQNKVSDVQLQTLLTELRKYQTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHW0</accession>
    <name>A0A1D8PHW0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sedoheptulose-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C207420WA</name>
        <name evidence="3" type="ordered locus">orf19.9445</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713146.2">
        <property type="nucleotide sequence ID" value="XM_708053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHW0"/>
    <dbReference type="SMR" id="A0A1D8PHW0"/>
    <dbReference type="FunCoup" id="A0A1D8PHW0">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHW0"/>
    <dbReference type="GeneID" id="3645202"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207420WA"/>
    <dbReference type="CGD" id="CAL0000182609">
        <property type="gene designation" value="orf19.9445"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07420W_A"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHW0"/>
    <dbReference type="OMA" id="GWLIWRD"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000182609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="240" mass="27175" checksum="B5A3A1C3803719D5" modified="2017-01-18" version="1">MTKSPCPRLIFVRHGQTEWSKSGQYTSRTDLDLTPFGVKQMRNTGKGLIGPGNLQMIKPENLTHIFVSPRKRAQRTSQLLLEEVDPEIKDKIPIEIDEDVREWEYGEYEGLKTNEIIELRKQKGLDKDSEWTIWGKGCEGGEQHYEVAARLDRFIEKIQKIHREALAKGVASDIIVVAHGHILRCLVARWVKRELSTNPQLILDAGGVGVLSYQHHNVDEPAIYLAGAFTVPVEEEGADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PI65_CANAL</name>
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        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
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        <name evidence="3" type="ordered locus">CAALFM_C208510WA</name>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714469.2">
        <property type="nucleotide sequence ID" value="XM_709376.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI65"/>
    <dbReference type="SMR" id="A0A1D8PI65"/>
    <dbReference type="GeneID" id="3643922"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208510WA"/>
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        <property type="gene designation" value="orf19.11110"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000195938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="239" mass="26921" checksum="387C46667CB667D3" modified="2017-01-18" version="1">MTVLPLIDSSSVSASSSSSSFESQLNSHPQYINIINQYQNFIKTNNETSKIIERIMPNLTGETLKGDDKINLRTKTLYFINDEYLLHHQEIPPGNSSSTSSNGSNYSVTFFHLGHKLTGHKGIIHGGLLATLLDELTCRLAFLNFENQRGVTANLNIDYKQPTIANQFIMIKCIVLEKSGRKCWVKGEVYKLNNQHQEEGEGEGDEVDDDYDLIIDKPENLLTSCKVLVIEPKWVDKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIN9</accession>
    <name>A0A1D8PIN9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C210120WA</name>
        <name evidence="4" type="ordered locus">orf19.9338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714414.1">
        <property type="nucleotide sequence ID" value="XM_709321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PIN9"/>
    <dbReference type="SMR" id="A0A1D8PIN9"/>
    <dbReference type="FunCoup" id="A0A1D8PIN9">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PIN9"/>
    <dbReference type="GeneID" id="3643936"/>
    <dbReference type="KEGG" id="cal:CAALFM_C210120WA"/>
    <dbReference type="CGD" id="CAL0000200486">
        <property type="gene designation" value="orf19.9338"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_10120W_A"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PIN9"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903333">
        <property type="term" value="P:negative regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000200486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="265" mass="30710" checksum="F389AFB71E344B72" modified="2017-01-18" version="1">MNNDPKFQVQVDPNEDTEWNDILRQHGIIPEKPPSPSVELETALEEAIVKQYDNRLENKDLDELDELEDEEDEDFLNHYKQKRMAEIKKLSEKKKFGHVLPISKNEYENEVTKASKESYVLVHLSLQSSLQSRLLSSILIDLASKFPELKICDIPAQRCIENYPESNCPTLIIYHDTNVVKQFITLTQLGGNATTLKDVETALADLNVIGFHDKRLIINNDEDEDLEQARKLRFAKKSIRDGNRNNEKDKDEDDDDDEDDDDFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIQ7</accession>
    <name>A0A1D8PIQ7_CANAL</name>
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            <fullName evidence="12">GTPase-activating protein GYP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name evidence="16" type="ordered locus">CAALFM_C210610WA</name>
        <name evidence="15" type="ordered locus">orf19.12800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OCA5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="14">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIR2</accession>
    <name>A0A1D8PIR2_CANAL</name>
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        <submittedName>
            <fullName evidence="5">Gcn1p</fullName>
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    <gene>
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        <name evidence="5" type="ordered locus">CAALFM_C210550CA</name>
        <name evidence="4" type="ordered locus">orf19.12788</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW28023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717136.2">
        <property type="nucleotide sequence ID" value="XM_712043.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PIR2"/>
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    <dbReference type="CGD" id="CAL0000192579">
        <property type="gene designation" value="GCN1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1242">
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    </dbReference>
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    <dbReference type="OMA" id="SMKIFLH"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25786">
        <property type="entry name" value="HEAT_GCN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="3">
        <location>
            <begin position="1409"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="1573"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000192579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2415" mass="265910" checksum="E267985E49E2FB48" modified="2017-01-18" version="1">MTDSWETLEPVYEKGISDSLVSVRIPILSSIKSVLSEIPEQELNKIVVALLKTFNYYHDAQSRNTVLSVVQAIGGHNPNYFQVYIRFIKQQVDGPTLPITDYMTLLQWINAFVVALARLGKLDDSVALAQGKLLSKCITFEGKRRRIYKSAIQTTKTAISDAVAIDSGYLDIIVKNKSFALLGVLDSALDKHPGLFEVYKEKYAPEILDFFVNQGLLSKVPPPTQDLAVFGSCIKSLVIDFSGLVPHIEKAILRSSENSFVYTLPVLFENLSIDIELSAKLVNAIISGIKSTKEHVRTGAAKTLELTLQKNTADLVDEIFRAIKATSNAEAKALIIKSLLHLHDSEKIVKQLLPLVSKDQNETSLASSVRVFTYHSLKYHNDEVVKQFITGFNSAKLRRVWFSEFGELVETVSFPEFVPEFEKILKGIEEAPLPSVSNKSIVCAFVILALTGKDSPLLNDSRIFSKLDEVELKWLVRALKNDPAGWIYVLTNAPYKIRLFALEKVVLNDELSEGLIKELLNGDLAHVGPVFALLSRYTKNFTSLILPASKAGVDWIALAQKSKIDLGKLVGENFGAIFNECVNDGSPAAIKAIADIAFIQPDLIEPIVSLIDLDVSKLNFSQQEIDIYQGQEGELVVNVLNEKQLDKNSKDYEIKKWEQSIKKELKQPKKLSKEEQALVNKQLAKESEIRTRVGEVVKRTNFVISLIIQLTKQARLVNNGANLWFPVAVNKLLALPQSPLFNPIDAFLELSSLISPRLGVLCKFIGVATLRSYGLKLDESLEQEPLVSLLGRILYRIKMLSDQQPLDSLSLSYVLPLLTRVLYDGKAVAIKNASKVAVTSEFVEEDPEEEQLLLAIEIISAHAESFEDDKIPRTSILEVLISLMKLPSKAKLSKECFLSLCQHIAFNICEGDLQLLLGSLITPHVFVRSTLLEGLDAEFELEKYSKELFVVAHDNDQNCREIAQTIWDDNELKVEDASNLLSLFGNSDAGLRNSIAHAYVDACQQTSLNIQELFALYEEKKDPPAPKLDQFGLVIKSTIDNRDRWEERSTVAIALKLLAPLYTEAHVKQLFEFLVETCDKDELVAQELQDAGVEAIKLHGASNVEVLIPIFENSLAKTSKESVVVLYGTLARDLDKNDPRLKIIIDRLMKSLDTPAVQYAVSECIAPLVVAMDNLPQVFDELFEKLFTAKKVSSRRGAAYGIAGLVKGSGIKSLSSYDIIRNLTDAAEEKDAIKRESVSVAFETLSRSLGKYFEPYVLEILPIILKSLGDPIPEVRLATDNAAKEIMKNTTSFGVKKLIPLAISNLDEIAWRSKKGSVELLGSMAYLDPTQLSASLSIIIPQIVGVLNDTHKEVRKAASAALQRFGEVIRNPEIQAIVPDLINAIGDPTKYTDEALDKLIKTQFVHYIDGPSLALIIHVIYRGMKDRASTKKKACQIVGNMAILVDSKDLRPYLNELVGELEIAMVDPVPATRSTAARALGSLVEKLGEDSFPGLIGKLVATLEDDTKAGDRLGSAQALAEVICGLGINKLEEMLPLILSSAGAPRTRAGFMPLLLFLPVCFGSQFSPYLNKIIPPILKGLADQDEEVRDTALKAGRLIVKNYAKKAVDLLLPELENGLSDSSYRIRLSSVELTGDLLFQITGISGKNELTEDQNLNKTLVEVLGQERRDRVLALLFVCRSDVAGIVRNATVDIWKALVANTPRTVKEILPSLTAIVVSKLSSPDDVQRTIAAQTLGEMVRRVGANALAQLLPTLQESDDKQGVCIAVTELIKSTSHDGLVQYQDIFIDIIKDGLVSSREEAAVAFDELHQELGKVVIDEIVPDLLKRLKEPNALLALKDIMSKKSDVIFPILLPTLLTSPVDTEALAALAPVAGSALYKRLAVIINTLVNAESEAIDEVMLSVEDDGVHTLMQIIMGLLKDEDTKRRVFIFSRLAGFFANTELDYSMYLEDMVTRLILSLADPSPDVVKGAFEALSALVKRQPKEVLEKLVKPAKQTLDLCIDIPAFSLPKGPNCILPIFLHGLMYGNHKEEAALGIADIIDKTPAENLRPFSTSITGPLIRVIGEKVASDIKAAILVALNNLLLKIPQFLRPFIPQLQRTFVRSLSDSNEKLRKRAVVALGTLIKFQPRVDSLVTELVNGSKTSEYKDSMLKAMLVVVEQAGKNLSEASKQAILSVAEQEMDPVLIGSLAGSLSEEEAESILDGILASQTKFSILAINSFLKYSPDHVKNNAGVAEFVVGCANSDNAYMSDNATIAIGKLLLLGVESKELVDQLALNAVAPKSSSPDTRRLSLVVLRTVARHKGITDLDTVVPSIFACVRDPIIPIKLAAEKAYLEVFDMVNGSAKFDGWFKNENLTTVTGTTIAARSIGDYTKRVATRLAGVERERIEAGGDEETLFSDRIEDENEIWQVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJA9</accession>
    <name>A0A1D8PJA9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PAL1</name>
        <name evidence="3" type="ordered locus">CAALFM_C301890CA</name>
        <name evidence="2" type="ordered locus">orf19.9226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330834.1">
        <property type="nucleotide sequence ID" value="XM_019475289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJA9"/>
    <dbReference type="FunCoup" id="A0A1D8PJA9">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="GeneID" id="3636561"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301890CA"/>
    <dbReference type="CGD" id="CAL0000201534">
        <property type="gene designation" value="PAL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01890C_A"/>
    <dbReference type="eggNOG" id="ENOG502QPHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJA9"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW28228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="443" mass="49193" checksum="9B6949A1038B65C6" modified="2017-01-18" version="1">MYQQPSNHSYSSTDSLRWSSNNPFRQASISQTQPRNNFDEWVDKNKQLLDLSSDEEVEEEEHGAAIGFHQSTESFGKPSAFPPTPVRADSDSSINYARMSKNPFASALSQSEDKPRAQTPTHSSRAPPRPPKPSQKQPPPPSYEEAAGPEAAKKSYPREKEGRSEDSRERRRENSRSGHSRENGHSSHSRSYGREHGRGSDRDKDRERRSHRSKKSPSKKKSDPVKPKNLDTIDKLDVTGFVGFHHDGPFDACAPHRNIKKEKAPVMAFPIDGPNNSIAGGTNMTKDDQLNLAFGNYHEETPVIKTNRTQNDPTSSIYTPKQNPSVINFDSNTNSTPIHGSTTAGLGSTTFLDGAPAPKGDELLNPNAGVGRKKSIVQRLRKNSGSESNSRRSSNEGLQPPSPPYQEPRRGSLNTLELDNDDNELKPPGNSFIRRVRSLKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJG8</accession>
    <name>A0A1D8PJG8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C302580CA</name>
        <name evidence="10" type="ordered locus">orf19.7878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_714853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJG8"/>
    <dbReference type="SMR" id="A0A1D8PJG8"/>
    <dbReference type="FunCoup" id="A0A1D8PJG8">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="GeneID" id="3638376"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302580CA"/>
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        <property type="gene designation" value="orf19.7878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02580C_A"/>
    <dbReference type="eggNOG" id="ENOG502S1H5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJG8"/>
    <dbReference type="OMA" id="RITKLMH"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
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    </dbReference>
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        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000195261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="244" mass="27981" checksum="41EBC421B133D913" modified="2017-01-18" version="1">MQDLDTPKEVPQAIRQANTDEEANIENGNESQQQQQREQQQQEPENHTNEIITNSNNSTDSTFSDTEDDYMLSDDEELNRILSRETSNHHHHGLPSSGSMVDHAQFFAEALSHALDSIDIDRSLVLQAQISGKLNNENQKIIEKKEILIEKLKNIQLMYGKNFGLLADGKESRVDKMKKDISFIENRITKLMHGGSETKSSIPFFKNKSNMGVEQKYPIEFNQAKDKVIERQIDDDDDNEEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJT1</accession>
    <name>A0A1D8PJT1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosylmethionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C303310CA</name>
        <name evidence="6" type="ordered locus">orf19.7963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720026.2">
        <property type="nucleotide sequence ID" value="XM_714933.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJT1"/>
    <dbReference type="SMR" id="A0A1D8PJT1"/>
    <dbReference type="FunCoup" id="A0A1D8PJT1">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJT1"/>
    <dbReference type="GeneID" id="3638363"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303310CA"/>
    <dbReference type="CGD" id="CAL0000195855">
        <property type="gene designation" value="orf19.7963"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03310C_A"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJT1"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000345">
        <property type="entry name" value="S-adenosylmethionine-dependent methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000195855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="221" mass="24631" checksum="891DB5876BC757C5" modified="2017-01-18" version="1">MLPTPTVKNIDYDEVYEPSEDSFLLLDCFEKEKDYLQSKFKTVVPLVTEIGTGSGIVTTFVAKHIVPNGIFLTTDINPHACETVLQTVKHNNDIGSSNCLLDSTQMDLTSAIKEREVDLLIFNPPYVPSSEIPEIPRTNNDPVWLDLALVGGEDGMVITWKVLNNLTNVLSKSGVAYILFCARNKPETVTSIMQSKGWNVEVVINRKAGWEVLSVLKFTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJZ1</accession>
    <name>A0A1D8PJZ1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein kinase RAD53</fullName>
            <ecNumber evidence="7">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">RAD53</name>
        <name evidence="13" type="ordered locus">CAALFM_C303810WA</name>
        <name evidence="12" type="ordered locus">orf19.14198</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_707644.2"/>
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        <property type="gene designation" value="RAD53"/>
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    <dbReference type="VEuPathDB" id="FungiDB:C3_03810W_A"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="term" value="P:deoxyribonucleoside triphosphate biosynthetic process"/>
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        <property type="term" value="P:filamentous growth"/>
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        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
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        <property type="term" value="P:telomere maintenance in response to DNA damage"/>
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        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="Ser/Thr_kinase_Rad53"/>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Pkinase"/>
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        <property type="entry name" value="Ser/Thr_PK_RAD53"/>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="583"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000193688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="699" mass="78327" checksum="89972D3E4B16FE8D" modified="2017-01-18" version="1">MEVTQRTQSQTQPTQQSPTTQTQTQSKEDQNRICQLICSTGQFGNYDLNINDKTIVQGKMTWYFGRDPNSDLQVASSSRISNKHFQIWFNFNDKSLWIKDTSTNGTHLNNSRLVKGSNYLLNQGDEIAVGVGRDEDVVRFVVVFGDKYNPAKLPDSTNTIKDEGIYKDFIVKNETIGQGAFATVKKAIERSTGESYAVKIINRRKALNTGGGSAMAGVDRELSILERLNHPNIVALKAFYEDMDNYYIVMELVPGGDLMDFVAANGAIGEDATQVITKQILEGIAYVHNLGISHRDLKPDNILIMQDDPILVKITDFGLAKFSDNSTFMKTFCGTLAYVAPEVITGKYGSSQMESQQKDNYSSLVDIWSLGCLVYVLLTSHLPFNGKNQQQMFAKIKRGEFHEAPLNSYDISEDGRDFLQCCLQVNPKLRMTAAEALKHKWLQDLYEEDSVKSLSLSQSQSQQSRKIDNGIHIESLSKIDEDVMLRPLDSERNRKSSKQQDFKVPKRVIPLSQHPATPLPMSQPKKRPYQIDPRTNKKVDLEEPSTSKKVKLSDSVVAEDYLKLEPLANSLFQETINISKSPFSFGRNDTCDCEIDDDRLSKLHCVITKENDSIWLLDKSTNSCLVNNTSVGKGNKVLLRGGEILHLFFDPLSSQHIGFKVVLVDQSSGEHKSQVEALKQTSEEMNIIPLISGLSSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKD7</accession>
    <name>A0A1D8PKD7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ato5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ATO5</name>
        <name evidence="8" type="ordered locus">CAALFM_C305620WA</name>
        <name evidence="7" type="ordered locus">orf19.6997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714703.1">
        <property type="nucleotide sequence ID" value="XM_709610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKD7"/>
    <dbReference type="SMR" id="A0A1D8PKD7"/>
    <dbReference type="STRING" id="237561.A0A1D8PKD7"/>
    <dbReference type="GeneID" id="3643652"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305620WA"/>
    <dbReference type="CGD" id="CAL0000174804">
        <property type="gene designation" value="ATO5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05620W_A"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKD7"/>
    <dbReference type="OMA" id="INTFAGW"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071469">
        <property type="term" value="P:cellular response to alkaline pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        </source>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="FunCoup" id="A0A1D8PL39">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Alba-like_dom_sf"/>
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        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
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        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
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    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000175247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="167" mass="19128" checksum="25B2F095945B2BBA" modified="2017-01-18" version="1">MGTNNKTVTNKSNKRIQGKRHIKHSPNLTPFNETQNASNFLIKSSTPYISAIKQITKKLNKFSKSKNSHTINKFQNEQYKTIKYIAVKGMGKTIEKVASIGTHFQKDYKVDVLTGSTTVLDEFAPIESNQEPDNENKSDDDDDDDDETIYKKRTVSSIEIRIWIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLD6</accession>
    <name>A0A1D8PLD6_CANAL</name>
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        <submittedName>
            <fullName evidence="17">Pdc12p</fullName>
        </submittedName>
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    <gene>
        <name evidence="16 17" type="primary">PDC12</name>
        <name evidence="17" type="ordered locus">CAALFM_C401850CA</name>
        <name evidence="16" type="ordered locus">orf19.12078</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330908.1">
        <property type="nucleotide sequence ID" value="XM_019475363.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PLD6"/>
    <dbReference type="STRING" id="237561.A0A1D8PLD6"/>
    <dbReference type="GeneID" id="3635591"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401850CA"/>
    <dbReference type="CGD" id="CAL0000189869">
        <property type="gene designation" value="PDC12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01850C_A"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PLD6"/>
    <dbReference type="OMA" id="EARFPNN"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:nucleus"/>
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    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="427"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>2</label>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000189869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW28956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="599" mass="65152" checksum="91090A2393F10C63" modified="2017-01-18" version="1">MREISLGRYIFERLYQLNVHTVFGVPGDFNLSLLDKIYETENEHGGGSFIWAGNCNELNAAYSADGYSRVNSGKIGALVTTFGVGELSALNGIAGSYAEHVGIVHIVGVPSNEAQKKQMLLHHTLGNGDFTVFHRMSTNICETTAFLDDLATACNEIDRCLRTAYTMQRPVYIALPSNMVDMKVPQAMLEKSIDLSLEPNNIQSQNEVIDRILGMVSKASNPIVLVDACASRHDCKKEVKQLVETTQFPVYVTPMGKGMIDEGGIGGEDLADASAFKNLASNLSSGTSVASRYGGVYIGSLSKPEVKEGIENSDLIFSCGALLSDFNTGSFSYSIGTKNVIEFHSDHAKIKSAIYSGIKMKELMQALNKKISSVLTNYVPKSVPKVKLVNAPTELSAPLTQAWFWTRVSSWFKEEDIIITESGTAAHGILEARFPNNVVGISQILWGSIGYSVGATLGASVAAKEVDPKKRVILFVGDGSLQLTMQEVSTMIKNGVHPYIFVVNNAGYTIEKLIHGLNAKYNNIQPWNHSQILSLFNAKDSQSAKISTVGEADDLFRNKYFGVNSKIRLIELMFSSLDAPKALVQQAKAAADVNRGTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLR3</accession>
    <name>A0A1D8PLR3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C403080WA</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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            <end position="233"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="810" mass="93903" checksum="1CCDD1FE24E87CE3" modified="2017-01-18" version="1">MSSRSNSPSKTLTENIDKSFSPIKINLTATDDNSPNKSIIHHKTPSRIVHHPHGLSAKHEARRNTIGYSNSIKRRGLVHTPLIPPGSVRNPITSPRLAVRPPINLESIKRTNQKMAQQIKLAFPANNDDDKENELHLDLSSDPDEDYSSPIKRHTRPRNDGDDDNEHSEHLSKIPKLSRPSEEKQTLPETDTNEVEEIKSIEDNSIEENNRSNLAIEEENDNDSDNEEDDDDITKESRGSTVYHQNQTLDNTQISKIIREDLKLDYITPERATEAVAQSPHPHHQHIRLIEEDKTEDFGKFNDTTSPLKTRNQDENEFDDETANLTLSRQLENEPTINFLMSPNSKPVFSKDQVNKIQKEHESKVDTLLQQLNSRDDKIKQLYDELAKVNEQLISSQKEQRALNDEKSKLANSENLLTIQLHHNERELASLTKSFRLKESSLNNLKRKLNEQKVSIDETRHENDTLKSKINELQSLERDLKAEIVETSNSNIESTLKLDQVIKEKEELWIKNQELNEKLQSFESNSSSKYDKLKDEYEDLSERNQTLVDDNKRLETEKFELEDKTKKLEAVNQKLKDDNTNNENLIKEYEKVATSRIEELESERDSTIEEISKHKQIVHDLETQVENLKQQYNDKEKTNKELESRIEELESKSVSNDELQELKRKIDAKDKEIETKEKTIEDYLSKMDDLVDHIKPLKKENEDLKQEQQKLIQEVSSLKDKLEKSKIQADEDLDKLSKYLYAEYAAKHIKKLEGIIKENKKLERELEFYKMKLEKANKEAELLSERKVSSSSKTALSPKITAAPKNRGKH</sequence>
</entry>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PNA1"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
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    </dbReference>
    <dbReference type="Pfam" id="PF16958">
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    </dbReference>
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        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000180558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="513" mass="59658" checksum="161141DCF94D7136" modified="2017-01-18" version="1">MSNFIEVQRSNIQEIGIIEDSLSRRLLRNPYILPSNLQPRPNILVSKVTKPNSTKRISILQQYELGYFKDRYNQIIKGLNHCLTDEKESFSRTLELITEPGDGFEKFDEMINGISSNDNIVEDPRKLYSSFSSLNKELNPQDVTLKINKKTGKEQEFVKRKHFLSSIASHLKNIEINDIMDLHHFHDLYVSNFGPISYIEYLYKFSSFPYANVNGFYSKYLTELSSFLEATLIKLQPLLDYNALLQNWKKEYDNANEERKSNGNDGDKLFCKACNKLFSKETVYQSHLSGKKHKKNASQQNPDNFVSSLPWLEYFIEKLCQVLAPELEYTRAQVEKLSNLSERELQLDRQVQHNIENEFVAINNEFDDDDLSQNEHGDDDDNDNYLDDSFKNLPLGPDGTPIPFWLYKLQGLHKQYNCEICGNISYKGKSVFMKHFSGSKHQYGLKCLGVDEKNMKMFKNITKIDEATELWKVLRKETKLKVTELENSVEVEDKEGNVMSEKDYIDLKKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNQ8</accession>
    <name>A0A1D8PNQ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">MDJ1</name>
        <name evidence="11" type="ordered locus">CAALFM_C503600WA</name>
        <name evidence="10" type="ordered locus">orf19.6672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711424.1">
        <property type="nucleotide sequence ID" value="XM_706332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNQ8"/>
    <dbReference type="SMR" id="A0A1D8PNQ8"/>
    <dbReference type="FunCoup" id="A0A1D8PNQ8">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNQ8"/>
    <dbReference type="GeneID" id="3646980"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503600WA"/>
    <dbReference type="CGD" id="CAL0000175831">
        <property type="gene designation" value="MDJ1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03600W_A"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNQ8"/>
    <dbReference type="OMA" id="MATDYYA"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000175831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="488" mass="52937" checksum="128A69B925FA372F" modified="2017-01-18" version="1">MRIPSARFVRTGLCSFKPRSFASGRLPYTYLATRAFHSSKIRAINFDPYKTLGVDKSADDRQIKKAYYDLVKKYHPDVNKEKDAEKRFHKIQESYELLRDKEKRAQYDQFGASAFDANGNANPFAGQGGNPFGGFGGGSAGGNPFSGMGFDFEDLFREAFAGGRGGAGGGRGGRSFVTEHVGDNIEVLKTIPFKDSIFGTSVTINYKAVDSCTTCSGSGLKAGAKKNTCPTCHGAGQTTHVMGGFHMSSTCPSCQGAGVTISKSDECGTCHGHGVQEIPKSKTVEIPAGVSDGTRIRIPGAGDAPMVTKDPYNQLVNGDLIIRINVQKDPVFSRNKNDLVINEEILMTTAALGGEIVVPTLDGQKIKLKVRPGVQNGRKLTIPEKGVPINRNLNNRGNLEVILNVKTVVPETPTQKALLEALADTFNDKNAKRTDADWSLDIEDDKNGKVNETYDESDLHPSKLKRIGKVLGKFFNFEQNDKGTKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PP29</accession>
    <name>A0A1D8PP29_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C504860CA</name>
        <name evidence="8" type="ordered locus">orf19.11455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        </source>
    </reference>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        </source>
    </reference>
    <reference evidence="9 10" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="6">Belongs to the GOT1 family.</text>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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    </reference>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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        <scope>GENOME REANNOTATION</scope>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
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    <sequence length="113" mass="12721" checksum="A9D8BD926FC165E2" modified="2017-01-18" version="1" fragment="single">AWLLKKKSDVFCHLFFAIFFFSSAFFSPSFFVDVSXAHRSPTGLPPAPRFSQLHNQSPPKQSNNLPTKLHNRVATLIVXSTCLAVSKFNFCHLKLKNRLPLLLSVNSILSLLL</sequence>
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    <reference evidence="3 4" key="1">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="3 4" key="2">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
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        <location>
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            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    <sequence length="361" mass="36454" checksum="F4C08ED657F26B3E" modified="2017-01-18" version="1">MKFLLLLLAGVAIAESSVEVAPSEVVPSVEVVPSVVPVEAVSDLQIKASVASPAASPTAATTSGSLFGDLVDGLFGGAQNSSAIATPTTTATAAQSTGGFLDGLFGGSNTVANSTGSSDGSLSDLFDEWFGPSNYTKTAGAPSSSTGSILDGLFDDLFGDSGSNSVSTNTGSTSSSGSWIDDLLNEFLAPSNSSDSTAPSFDGGDLLNDILGIGENLAEDLFSNIDGKSILTGVLGFAGEIFDDLFSSFGSSSGGFLSSLLNSIFGDSGSSSSSSSSSVPSTSISDIVSDVFTSLFGGILGGSSGYTGSTSKVCTLKKRSLEKKEIRKLVRKSVNKVIARRQQAIAEKKQANAKRESVVLA</sequence>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">PKH3</name>
        <name evidence="14" type="ordered locus">CAALFM_C600350WA</name>
        <name evidence="13" type="ordered locus">orf19.8787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW29984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712313.2">
        <property type="nucleotide sequence ID" value="XM_707220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPB9"/>
    <dbReference type="SMR" id="A0A1D8PPB9"/>
    <dbReference type="FunCoup" id="A0A1D8PPB9">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPB9"/>
    <dbReference type="GeneID" id="3646075"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600350WA"/>
    <dbReference type="CGD" id="CAL0000179865">
        <property type="gene designation" value="PKH3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00350W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPB9"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000534">
        <property type="entry name" value="Serine/threonine-protein kinase PKH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057614">
        <property type="entry name" value="PH_PKH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25347">
        <property type="entry name" value="PH_PKH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="45"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="787"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="831"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000179865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW29984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="861" mass="96464" checksum="5A520AA8592961C9" modified="2017-01-18" version="1">MSGLEHLQNLSIQPSNRSTQQQQTNSQPQSQYSQSAAKRRSARDYQFGAKIGEGSYSTVYSALDKYTNRTYAIKVLSKRHIVKENKIKYVNIEKTTLNRLGQQHPGIVQLYYTFQDESSLFFVLDFAEYGELLSIIRKFGSLSESVSKFYMCQIIDAVRFIHSKGVIHRDLKPENILVGHDFNLKITDFGAAKLLGNHEEFNGEKIDYNSVDASPEVSDTDRKGSFVGTAEYVSPELLKHNICGFESDIWAIGCILYQFFNGVPPFKGSTEYLTFEKIINVDYSYKSPIPLPPDVIQLIDSILISEPSARATIPHIMSSRWFSDIPWDDQNFIWHRKVPRFEAFGAITPSPAMPPMMKNGTNRNVNKSNSYHQLQSQISASEFGFIPSIAAKKSYKPPTMIKNNVAMPALNQTTYNHNYQQHVPLPPPVSSQPLTQQNVPQQIQPQRSGSAQTPQFAPVSASSRQPVGNMQTRQAAPQVLVQQKTPPFPKEKNSTPNLRDNTSFAQMAPRRNGEIPGQPQQQIPLPKSQQSPQPQPKAQYQSQQQKQSEDIRGSKNTSANAAAAAFATKNLPQPNHKTSKDSSTPPPPPPLPPKIKKVQENFIKFNEVSGLLKPDEKILKMDNLIKSVLSKRYLNKPEYQVLDDSVLDELTSKYASILKQESKAVITIVTNMARVFFIDAFLNVMLVDLKANKGADYSMYDYEFENTVDEDGNLLSKQDETFGYLIIELIKDGGDLVFLQRVSDEQRLRLTNAVKVLDKKGEEVVVGSSHGWIDCLLIAREISIEQSEDNKKPRSVSSSSNVSINEVKSEKAKKKKSSLSNKKPRSKKKGTSSNGTPQTTPTPTQHSNFAFAAAAAVHHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPE8</accession>
    <name>A0A1D8PPE8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cox15p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">COX15</name>
        <name evidence="14" type="ordered locus">CAALFM_C600720CA</name>
        <name evidence="13" type="ordered locus">orf19.11140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_711328.2">
        <property type="nucleotide sequence ID" value="XM_706236.2"/>
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        <property type="gene designation" value="COX15"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="term" value="F:heme A synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
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        <property type="term" value="P:heme A biosynthetic process"/>
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        <property type="entry name" value="HemeA_synth_type2"/>
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        <property type="entry name" value="COX15/CtaA_fam"/>
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        <property type="entry name" value="HemeA_Synthase_type2"/>
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        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
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        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="191"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
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            <dbReference type="ARBA" id="ARBA00048044"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000185068"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30018.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="479" mass="53427" checksum="B5FE08D94DCA869D" modified="2017-01-18" version="1">MLSKTRFFFTKNSLVLNTLQQNKGCKLSIVSRTAPASKLFPSSFKISRIFNNLSKRKYSTISHRVDSTFTKTEFVKSTPPPVIPQKSIGYWLLGTSTLVFGIVVLGGLTRLTESGLSITEWKPVTGAVPPLNQQEWEEEFNKYKNSPEFKQLNSHITLDEFKFIFGMEWGHRLVGRCIGAFFILPALYFWARGRFTPQLTKRVVGLTGLLGLQGFIGWWMVKSGLDEEQLAERKSKPTVSQYRLTTHLGAAFLMYLGVLWTAFEIFNENKLANLAKKSPEAVQAILKQLNNPALKKTKIVGLSLLALTFVTAMSGGMVAGLDAGLIYNTFPHMGDDWIPNGSELMSPVFSRKSDQSDLWWRNLLENPTTVQLVHRIFATTTFFAVLGAHIYVNRNKGVVPIAAKRIMHGVMGVVTLQVALGITTLIYLVPIPLAALHQAGALALLTASLAFSAKLKKPRPQFVQFINSNMKSKLLKTRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPN6</accession>
    <name>RL32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL32</name>
        <name type="ORF">CAALFM_C601700WA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019475456.1"/>
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    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="AF=1-131"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="AF=1-131"/>
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    <dbReference type="PDB" id="7Q0F">
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        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="AF=1-131"/>
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    <dbReference type="PDB" id="7Q0P">
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        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="AF=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="AF=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="AF=1-131"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="AF=1-131"/>
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        <property type="resolution" value="2.15 A"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPN6"/>
    <dbReference type="EnsemblFungi" id="C6_01700W_A-T">
        <property type="protein sequence ID" value="C6_01700W_A-T-p1"/>
        <property type="gene ID" value="C6_01700W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515335"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601700WA"/>
    <dbReference type="CGD" id="CAL0000179592">
        <property type="gene designation" value="RPL32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01700W_A"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
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    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456507" description="Large ribosomal subunit protein eL32">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30107.1"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="4 5" key="2">
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Weissman J.S."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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    </evidence>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="4 5" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000173955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="121" mass="13283" checksum="80554C923D93AA79" modified="2017-01-18" version="1">MPLLYKPAAEGKDVKPAQIPSPGNNSFLEDTFTSDAPKDKQISCGFYRQEKGEPLVYTYDCDEMKIIVEVSGEFTLTDETGKKVSAKPGDVFYFSKGTTITFESTDYALAFFTGLRPNGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ21</accession>
    <name>A0A1D8PQ21_CANAL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C603050CA</name>
        <name evidence="1" type="ordered locus">orf19.13034</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="3639270"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603050CA"/>
    <dbReference type="CGD" id="CAL0000191430">
        <property type="gene designation" value="orf19.13034"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S16T">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4095076at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000191430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="466" mass="55157" checksum="9F9E3B810787CE62" modified="2017-01-18" version="1">MLVKLPLEIQIKLLLMVPNSNLKFVNSHFYLLYNDLYYHKIVNTFGEATVKVIIKILPWLKPYIKSLDVFRKQARLIIAKRLQLEESPIIVHNPDFTTTVNPLNCQYIKDSWKYIYSILKNKRFYAEYCDYKIDEPSNYVFNHYVEINRTYLLSYNKVCWLAPGDYNLNIALAVKNGQGLGTTKFEVRYQELNELGETLIKSQTFYPPSNINEILPKNQFVCLNVGHFVIPPPSETESRFYFKQFQSNSDHNKLRRIEIVMEEIGLYLKSGFRVYFIDISQPSMLFNEYDLLYYSINETDYRYFINILLKNLYKALNYVQNAGCSDDLSYQYNRDVYGDGDPFSIINKYDKQFLLEYEKTNGFLSSSSSSSSLALNSLQDYVLYDNKKLLNYGRFFYLNKFTIRNFKFTTIYQQRQFINRFGDYLVDCKEQDSKKNVVDGDEIPIERNCSYDHYGLKWKLPILGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ64</accession>
    <name>A0A1D8PQ64_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C603520CA</name>
        <name evidence="10" type="ordered locus">orf19.13141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710069.2">
        <property type="nucleotide sequence ID" value="XM_704977.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1D8PQ64">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ64"/>
    <dbReference type="GeneID" id="3640259"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603520CA"/>
    <dbReference type="CGD" id="CAL0000190573">
        <property type="gene designation" value="orf19.13141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03520C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PQ64"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="CHCR"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
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        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="39"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="512"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000190573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="811" mass="94554" checksum="98D02A808D40CA2D" modified="2017-01-18" version="1">MSSNGHKTKSIKSETNSSYTVHSLDQQQASICDNLQQAKFELEPVHLQFSLSNKLNKLLVSSNIMYILLTNVVYKIDLXNPSQVENYALPGKVTNAWLNPNGQTLIVQIEKQAYYTLEKKVFKLLKFKNIEVTSIAFSNHNMVVGTKDGIIYVYEKSLKQVYKVDSPVQGVMFSNDYSQINVLANSLYTWDCFDTSYVELQKVFKQTAPVIKSINPPGIFTSNPQNYVYISSDNEIITNDEEMQLDRVDEEFSQIALTPHHLIGIEGNSLKIYNKLNKQLQELSLSENKIRGIAVDNLFNTYWVYTKNSIYEFVIENESISVWYDYYKMGKYSEALKYLDEDDEANFSKRDLVLIKQGYDYLQRGGFGISSDDLSLQIQGIQILAKSTEPFEKVCLMLLNHKQSDALLIEYLLAKLNKKNKVRXIVLSAWIIELMVRNDDSRVYEFIKTNYKLLDRPTMYQILNSEKLIFYAELIEDYNFILKYYIDKKNWTLAVKTLIKLYTKGDIELVYENATILLMNYPKVTETWLKLDLEYEKLLPALLKHQEQAIHFLQQVIMDKHYKKNKQLNNAYLCLLITKPGTDKQIIKFINFTSNFDTNFILRLCISHEKFHPAVLIYIEIGLFDQALELALKHDLTSLAEFILNKYDEDKQVEGIKLEDANYNVKRKLWLKFAKYLIDKSDDLNETLHHHINNVSMLDLKDLLPLFPETISINNFKDEIVESLNEYNKRIVHLSLDMNNSSEHLREMKKKVIYNKKKTNVAIIEPGEPCRKCGKLLVQKNFVYFPNCHHAFHXECMKKNQCLLCNDFLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ87</accession>
    <name>A0A1D8PQ87_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C603740WA</name>
        <name evidence="1" type="ordered locus">orf19.13171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="647"/>
            <end position="813"/>
        </location>
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            <begin position="814"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AOW30366.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="1425" mass="161878" checksum="1133B38D75790825" modified="2017-01-18" version="1">MPSASNHGTPRMVGGLINTPLARHINAKKVVNPVIQSFKVAHQRVNIDIDLSSNSIDGFTELTVIPTSNKLKVIKLDCREMEIKDVLINGSRSLNYVYDDLLYINNPEYFEHCIDSKVINVMDLYSDTFNVHQHHLIRSKLDYIFKNPKHDEESLDYNTQELKILLPDNMKFELTDINSIQTPSGTSHPGTTTPSHLKSKGTGNEYYYTPIQLKVVYKVKNPQNGVNFVTNEDIEKKLWHAYTTNSNYNVSTSSWVPCIDDLSSRCTWSLEVNIPRTLKDIGNPRMIGSKEALDYQQMRRKRSGEAIQNFAQQNNDSDDDDDDDEDIGNYDMVVPSGDFNNVKETPHPIDLSKKVVSWSIFNPVCAHHVGWAVGCFESFVLSDESAGAKEDDEEDTVLRGDDAENVNNPVTIYSLPEDVEWAKNTSIITNKALDFFSKEYGSFPFSSYAIVFVRYSPCQTSNFAGLSVMSSKLLYPPDMIEPMFTVTDILLKSIATQWAGINISPQTFNDMWCTIGIAGFMAISFIKKLMGANEFRYRLRKQMDKVVAEDVGRHAIASQPFKYPVSEDDLSFVWLKSPIVLFILDNRMTKTDKSFGLSRVLPKLFLQAMSGSLPNGTLNTEHFRYVCEKVNRNKLENFFKQWVFGAGAPVFRISQRFNKKKGMIEMNIRQVQHHERTPKKLDSSSFIGDAVAYLDNEPLPPQQHVFTGPMTIRVHESDGSPYEHIVELKEANTKLDIQYNSKFRKIKKKDDGVDPGIAFNQFGDVLLSHAEMQEWNLRDWDKRDEESLSSEPFEWIRGDVDFEWIARIDIKQPDFMFGSQLVYDRDIEAQLEAVRYFGELEKTNTTYCTALTRTLMDDRYFYGVRIAAAQALADCSNEANNFIGLEYLLKAFGKLYCFDDSFIPKSNDFSDFRSFMLQSAFPRILCGVKDNDGKVPKRIQNLLLNLVKFNDNSMNAFVDSLYVSELVVSLVTSTVSGWRNDIEEYNDTEFAGKVSSELFRLQKLDRWIPSYQNIIEVTCIQQNIRMALVGARKLSFEELLYMTLDKYPMEARVEAFRGILELGGLKNKSILQYFLKVCLLNFERPLYRSKLIEALVKSVSSVATYGGVSTLDDPEFHTKVDTNVKSSSNRIIIDDGSQDNLAMKSKRDDMARASIKGAIEILRRDFSEGQGLRETLWELLHTSLIGLHERRSIFCLCQVLFKGVDSYVVKLPVPSMPVEEYVRKKIVAKVSNYPGQVTIKREGRFKIQLATRKSVIAKVKSETEHKPLKISLKPVIEAKQKAASAVHVDPVIPTKVTFKLPGHRLAGFAKKVELDGTLVTIKLGRDMKSKVDALAHRYVRINTKRRKIEVSKVPFIEKEEGSNTSGITEVSRNTGEKEDAKSPSPILVKKEKKRPKVYIHFGGNVKKPDQGSSSSSSKEGSTEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQN7</accession>
    <name>A0A1D8PQN7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA-binding ribosome biosynthesis protein</fullName>
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    <gene>
        <name evidence="7 8" type="primary">NOP15</name>
        <name evidence="8" type="ordered locus">CAALFM_C700690WA</name>
        <name evidence="7" type="ordered locus">orf19.7050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715249.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PQN7"/>
    <dbReference type="FunCoup" id="A0A1D8PQN7">
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    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQN7"/>
    <dbReference type="GeneID" id="3637966"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700690WA"/>
    <dbReference type="CGD" id="CAL0000196813">
        <property type="gene designation" value="NOP15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00690W_A"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQN7"/>
    <dbReference type="OMA" id="HGFHEKE"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
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    </dbReference>
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    </dbReference>
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            <end position="202"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
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            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000196813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="267" mass="30499" checksum="EC9CDC1395196F86" modified="2017-01-18" version="1">MARKQVKSKVAEKVEKKQNITTPSEKSVEDIEHDLQLPSSSDEEEDIEQEELSEEESSGDEEEEEVEKEDNINGLSDEEQEEVQQQQQNKANKSGHSVNKIIKTSEATTTNTSANNKSTKSKSGVIYIGRLPSGFQESELKTYFSQFGDVINVKLARNKKTGNTKHYGFIEFDSIEVAKVAAETMNNYLLFGHLIKCEVVENPHEDTFKHGNRKFKVIPWKKIAKEKHEKSRTEEEWKVLIAKFEESKQKKQEELKSKGIDFDVSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQR5</accession>
    <name>A0A1D8PQR5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yox1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">YOX1</name>
        <name evidence="9" type="ordered locus">CAALFM_C700970CA</name>
        <name evidence="8" type="ordered locus">orf19.7017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="168" mass="19129" checksum="4F96EA4586F0C75D" modified="2017-01-18" version="1">MTHEIYSYSLEDLDKLEQDLKFPKFNADIAWQLGSLARSLALKKYPQKPIIINITLSNGHNLFQTATINGTILDNDKWVNRKINTVIRFEKSSFYIGQKLRNKMKSLEEANFISSIDYATHGGSIPLRLINFDGIIGALTISGLAQEEDHLFAIEVVKQFLETLNLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRG7</accession>
    <name>A0A1D8PRG7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C703890CA</name>
        <name evidence="4" type="ordered locus">orf19.7193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715241.1">
        <property type="nucleotide sequence ID" value="XM_710148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRG7"/>
    <dbReference type="SMR" id="A0A1D8PRG7"/>
    <dbReference type="FunCoup" id="A0A1D8PRG7">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRG7"/>
    <dbReference type="GeneID" id="3643108"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703890CA"/>
    <dbReference type="CGD" id="CAL0000180066">
        <property type="gene designation" value="orf19.7193"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03890C_A"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRG7"/>
    <dbReference type="OMA" id="HNNDTPY"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="103"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000180066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="676" mass="75672" checksum="0E3CAE7E05D8DCFC" modified="2017-01-18" version="1">MDSDPANILLLLVFASIVLFFALSFCAYRLFCRNSDRNEYSSLDSDILGSHSNNVPREFLNDEESLLDLAETFDFTNLSPEEQGSYLKGQEFTSNNPPDFTKVRGKTFTIEDEKLIKECGINAFQFDPDQELLNSRYIVADKTELNFNNNDMPYSTATAVLNYPLPVRNRVYSDIVYFETKVFEFNNENNPNAHFSIGLVTKPYPSAFRLPGYNKFSIGYESTGNLKINKPFPTPLQQHQDEHSEYNALVLPALQQSDIVGFGYVVSTGTIFITRNGKKVLDVMKGCFVDLYPAVGCFSTNAKFQVNLGQLGFVWIEANVRKYGFVSTSDYKKISGDRGLASLPQYDKVIVEGDKVLDKGEELPPRYPEEELDFFGRTVNDNVRVGSSSQHMKLNEKNENENENGDADAEVGNEVKEPIEGSSSQVTDEPEEVMDLRERIYEQNIQNDTSSIDESTPLISQNEISALDEIIESPLEDNKNEEVQTESQQLEPIEENEEEPQVSTNEVSRPQKNVLIENTESSVSKKKDNLKSSEAPSVILEQEQEQESASQPVPAPEQKQETEPAQEPVQEQESVSQQEQELVAEPAPAYTQTEEREREGQGDEEVDVTDEQPSNEGTSTEPSTSPEPTGNNENNNAGDTTPLATTIGSSSNNKSNQKKKKKKNGKKGGKKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PS27</accession>
    <name>A0A1D8PS27_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ptr2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">PTR2</name>
        <name evidence="12" type="ordered locus">CAALFM_CR01830CA</name>
        <name evidence="11" type="ordered locus">orf19.10115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331059.1">
        <property type="nucleotide sequence ID" value="XM_019475514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PS27"/>
    <dbReference type="SMR" id="A0A1D8PS27"/>
    <dbReference type="STRING" id="237561.A0A1D8PS27"/>
    <dbReference type="GeneID" id="3640089"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01830CA"/>
    <dbReference type="CGD" id="CAL0000200802">
        <property type="gene designation" value="PTR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01830C_A"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PS27"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042937">
        <property type="term" value="F:tripeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140206">
        <property type="term" value="P:dipeptide import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042938">
        <property type="term" value="P:dipeptide transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042939">
        <property type="term" value="P:tripeptide transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17350">
        <property type="entry name" value="MFS_PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="623" mass="69928" checksum="6D23A42465E73BC9" modified="2017-01-18" version="1">MVSSDFENEKQPDVVQVLTDEKNISLDDKYDYEDPKNYSTNYVDDYNPKGLRRPTPQESKSLRRVIGNIRYSTFMLCICEFAERASYYSTTGILTNYIQRRIDPDSPHGWGAPPPGSPDASAGALGKGLQAASALTNLLTFLAYVFPLIGGYLGDSTIGRWKAIQWGVFFGFVGHLFFIFASIPQAIENANAGLGLCVIAIITLSAGSGLMKPNLLPLVLDQYPEERDMVKVLPTGESIILDREKSLSRITNVFYLAINIGAFLQIATSYCERRVGFWLAFFVPMILYIIVPIFLFIVKPKLKIKPPQGQVMTNVVKILAVLFSGNFIKRLWNGTFWDHARPSHMEARGTIYYNSKKKSAITWSDQWILDIKQTFDSCKIFLYYIIFNLADSGLGSVETSLIGAMKLDGVPNDLFNNFNPLTIIILIPILEYGLYPLLNKFKIDFKPIWRICFGFVVCSFSQIAGFVLQKQVYEQSPCGYYATNCDSPAPITAWKASSLFILAAAGECWAYTTAYELAYTRSPPALKSLVYALFLVMSAFSAALSLAITPALKDPNLHWVFLAIGLAGFLCAIVMLAQFWNLDKWMENETNERERLDREEEEEANRGIHDVDHPIEAIVSIKS</sequence>
</entry>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710368.2">
        <property type="nucleotide sequence ID" value="XM_705276.2"/>
    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="519" mass="58953" checksum="2A39D640F56DD869" modified="2017-01-18" version="1">MKNQRPKPRYFMQDDDQAIHREPPRHLQLRVRSFTEPTPHCTADSTDRLVQTAQEPSFIEDSEDEIPVILSSISTSMPRFSSIYNSFHSSLETSHLLVNQHCDEEFQMHNENFNPQDFAVMSQLSYRHECNMSQPIMISNDDSDVILINSTIDQDEHEHEEYDYEGERNISIESDSTEEFDKGNILLGLESAKILAPKVEVDFSQEPNDDEILECSTQYGEEDDAIVVESDNMNVTLEVEGQQSEKLAEGERAKVEPTIIEDSEQSKISSNYIHETENEEILVESFPGEIKIVKRSPKKEDEKESLRAGMTEDNRVNKSQRKELRSQLDESYQNNSELKNEKEIGIPNDQISTSSCLDSNEEPNHDSKKTLKNSISENYTPPATNNSSVSSQNLHNSTPKTIAVNVKQNTNGKRTKENVKKSVKCDNEHVSKDITKSSNNSKSVPTKSSATETATSNLSHSKTASNKENIDAVRMNRKIVRKRIASKPLSEICNQHSRSRVGLSKRVKIDPLHQKLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT38</accession>
    <name>A0A1D8PT38_CANAL</name>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715894.2">
        <property type="nucleotide sequence ID" value="XM_710801.2"/>
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    <dbReference type="STRING" id="237561.A0A1D8PT38"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PT38"/>
    <dbReference type="GeneID" id="3642459"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05940WA"/>
    <dbReference type="CGD" id="CAL0000200092">
        <property type="gene designation" value="CEK2"/>
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    <dbReference type="eggNOG" id="KOG0660">
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    <dbReference type="InParanoid" id="A0A1D8PT38"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
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        <property type="component" value="Chromosome R"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="CGD"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of MAPK cascade"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:parasexual reproduction with cellular fusion"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:pheromone response MAPK cascade"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010526">
        <property type="term" value="P:transposable element silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000098">
        <property type="entry name" value="Mitogen-activated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000200092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="372" mass="43303" checksum="53B865C3C63580C2" modified="2017-01-18" version="1">MKKSTGPTQTRQVVFNISQNFKVLKILGEGAYGIVALAVHLPTETKVAIKKIEPFERPLFCLRTLREIKLLTKFKNHDNIVRLYDVQKPMNYDSFNEVYLIQEYMPSDLHNIIHTHLLSDQHVQYFIYQILKGLKMIHSARVIHRDLKPSNILVNEKCDLKICDFGLARLDTKHYNFDEAPRISMLTEYVATRWYRAPEIMLSASNYSTAIDLWSVGCILAELLTYRALFPGSDYINQLKLIFEVLGTPTDEDLQIIKSERAQKFIRSLPTKVKIDLSEFINNHPYRNIKHRGRDQVNPLAIDLLEKLLVFDPAKRITVQDALEHPYLNSYHEQLDEPVTSPIPIEEFDFDIDKKNLDTNDLKKQIFEIVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT42</accession>
    <name>A0A1D8PT42_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR05960WA</name>
        <name evidence="2" type="ordered locus">orf19.458.1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331092.1">
        <property type="nucleotide sequence ID" value="XM_019475547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PT42"/>
    <dbReference type="SMR" id="A0A1D8PT42"/>
    <dbReference type="GeneID" id="30515417"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05960WA"/>
    <dbReference type="CGD" id="CAL0000183787">
        <property type="gene designation" value="orf19.458.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05960W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PT42"/>
    <dbReference type="OMA" id="QDGMTER"/>
    <dbReference type="OrthoDB" id="4023651at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000183787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="91" mass="10273" checksum="B1980B516EC38D02" modified="2017-01-18" version="1">MPGIKKNRKTYNQSSFRRVLRSKLNSNEGSNTVGIKSDNCDILIYLIYMNYVNELINEGAKSQNGGAGEEGEVTEERLNNANDKLIKKYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PT92</accession>
    <name>A0A1D8PT92_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR06620WA</name>
        <name evidence="2" type="ordered locus">orf19.8316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2903" last="2912">
            <title>Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis.</title>
            <authorList>
                <person name="Kadosh D."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="15814840"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-01-0073"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2015" name="Front. Microbiol." volume="6" first="367" last="367">
            <title>Examining the virulence of Candida albicans transcription factor mutants using Galleria mellonella and mouse infection models.</title>
            <authorList>
                <person name="Amorim-Vaz S."/>
                <person name="Delarze E."/>
                <person name="Ischer F."/>
                <person name="Sanglard D."/>
                <person name="Coste A.T."/>
            </authorList>
            <dbReference type="PubMed" id="25999923"/>
            <dbReference type="DOI" id="10.3389/fmicb.2015.00367"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2017" name="Genetics" volume="205" first="559" last="576">
            <title>Zinc Cluster Transcription Factors Alter Virulence in Candida albicans.</title>
            <authorList>
                <person name="Issi L."/>
                <person name="Farrer R.A."/>
                <person name="Pastor K."/>
                <person name="Landry B."/>
                <person name="Delorey T."/>
                <person name="Bell G.W."/>
                <person name="Thompson D.A."/>
                <person name="Cuomo C.A."/>
                <person name="Rao R.P."/>
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            <dbReference type="PubMed" id="27932543"/>
            <dbReference type="DOI" id="10.1534/genetics.116.195024"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Transcription factor required for full virulence in mice (PubMed:25999923). Plays a role in cell-substrate adherence, a fundamental property that enables the formation of biofilms (PubMed:22359502).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 5 8">Expression is negatively reguled by the ZCFs master regulator of ZCF29 (PubMed:27932543). Expression is induced during filamentation and biofilm formation (PubMed:15814840, PubMed:22265407).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6 7">Reduces significantly cell-substrate adherence (PubMed:22359502). Affects virulence (PubMed:25999923).</text>
    </comment>
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    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000463363" description="Zinc cluster transcription factor ZCF39">
        <location>
            <begin position="1"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2 4">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15814840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="25999923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="27932543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="681" mass="78898" checksum="FAA9D1D87E14CD2E" modified="2017-01-18" version="1">MSTDTTANDEGKNEFSKQWRQSRACTRCRRFKKKCSFENPSFKSCARCFKNGYECSFNEDPAMQPSRKKKRKIQIDDNTHSSIANQLLSTSENTLKLLPEKLNDLSEDSIQHLISNYESIMDKLKSKIKPDTSNEFPYIPYSKNLAKELIYRYNYLTLAEVKTRLDFFLNEILPYYPTIPLSRKLKNFDYMLEKFPLLLIACIFVTVLNDNNLGTTPISKDNLKLCNLLSYYLYSFIAHEVYVKCEQFNIQLIYVCLISSSWCLPPIKLGHFRNQLNSLTASNIALCMGLNELPKNCFEIHLDEESELRNNLRALLSVYCSCGSLELSVRRFKVVTWTQSHQIAMNRLLETSSNQLPTLEDRYICYFAELVFTGHEILDFVDQINLAVNRSRISLSNIKRALRKYEQRLSQILDQSGFTSTKQALALQIQYFHLLVVIYDNLVSGVFNQSDEITPNYADEIPSSNERQFCLKMIIKLITSCESLVDQFVRLNNNIINIPSVLYYRPMHALILLVRLRLILKFQNFKDLEIDVESYFTKVSRVINDNLMKNSLVCSKMKVVLNKIEKWLILSQKYIKSDSVENNGPMNFDVVKIIFQNKDKEIENLDVPKSHNESPIKTNTTIESQDPSPVNSVDNPFTANNEFNGIISLEQIFQGIDSDISHYLNPLESNFDLSTDFNRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU62</accession>
    <name>A0A1D8PU62_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_CR10280WA</name>
        <name evidence="9" type="ordered locus">orf19.7603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719365.1">
        <property type="nucleotide sequence ID" value="XM_714272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU62"/>
    <dbReference type="SMR" id="A0A1D8PU62"/>
    <dbReference type="FunCoup" id="A0A1D8PU62">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU62"/>
    <dbReference type="GeneID" id="3638934"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10280WA"/>
    <dbReference type="CGD" id="CAL0000192669">
        <property type="gene designation" value="orf19.7603"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10280W_A"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU62"/>
    <dbReference type="OMA" id="NCARSWV"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000192669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12663" checksum="2B209EE9D9C33D82" modified="2017-01-18" version="1">MGFFTSSGEEVTFAPNKGQRVVCWEKRDGFFECLSKNYIDNSLDSKELDKVNKQCGTEKKEFEQNCATSWVKYFQEKRYNDLVRQRYIDKLESEGAQPLPFKIEGVKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2025-06-18" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>P43073</accession>
    <accession>A0A1D8PC52</accession>
    <accession>Q5AB75</accession>
    <name>TRPF_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName>PRAI</shortName>
            <ecNumber>5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TRP1</name>
        <name type="ordered locus">CAALFM_C100120CA</name>
        <name type="ORF">CaO19.13515</name>
        <name type="ORF">CaO19.6096</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Gene" volume="148" first="179" last="185">
            <title>Characterization of the Candida albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation.</title>
            <authorList>
                <person name="Ostrander D.B."/>
                <person name="Gorman J.A."/>
            </authorList>
            <dbReference type="PubMed" id="7958943"/>
            <dbReference type="DOI" id="10.1016/0378-1119(94)90687-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24"/>
    <dbReference type="EMBL" id="X78466">
        <property type="protein sequence ID" value="CAA55217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719055.1">
        <property type="nucleotide sequence ID" value="XM_713962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P43073"/>
    <dbReference type="SMR" id="P43073"/>
    <dbReference type="FunCoup" id="P43073">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P43073"/>
    <dbReference type="EnsemblFungi" id="C1_00120C_A-T">
        <property type="protein sequence ID" value="C1_00120C_A-T-p1"/>
        <property type="gene ID" value="C1_00120C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639321"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100120CA"/>
    <dbReference type="CGD" id="CAL0000186853">
        <property type="gene designation" value="TRP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00120C_A"/>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_1_0_1"/>
    <dbReference type="InParanoid" id="P43073"/>
    <dbReference type="OMA" id="FHGDESP"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="PRO" id="PR:P43073"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000199">
        <property type="entry name" value="Phosphoribosylanthranilate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894:SF1">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154330" description="N-(5'-phosphoribosyl)anthranilate isomerase">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA55217." evidence="1" ref="1">
        <original>G</original>
        <variation>S</variation>
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA55217." evidence="1" ref="1">
        <original>NGV</original>
        <variation>SGA</variation>
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA55217." evidence="1" ref="1">
        <original>K</original>
        <variation>Q</variation>
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA55217." evidence="1" ref="1">
        <original>KGHAQSS</original>
        <variation>QAHSLI</variation>
        <location>
            <begin position="220"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="226" mass="24768" checksum="384C76FAD3AAB12A" modified="2011-10-19" version="2">MKVVKICGIKTVEAASVAIDNGANLLGCILVPNRARTIDLEVAKQIARMVKRDRNPPPKFAGGTSTQHFEQVAQWIIENGPFLVGVFRNQPKEEVFRIAREVGLDFIQLHGSEDKLEFLGTEFGLIPRYVVPDELDLLEEQSLSLTQCVSLPLLDSEVGGEGKLLDWTFIEKLPTKAILAGGLTPENLPTFDNILGYDVSGGVETNGVKDSLKIIKFIQKGHAQSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-02-05" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>P87207</accession>
    <accession>A0A1D8PSZ3</accession>
    <accession>Q59KJ8</accession>
    <name>MNT3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable mannosyltransferase MNT3</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MNT3</name>
        <name type="ordered locus">CAALFM_CR05290WA</name>
        <name type="ORF">CaO19.8624</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Buurman E.T."/>
                <person name="Gow N.A.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>SGY243</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1-&gt;2)-D-mannosyl-D-mannose linkage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="Y13642">
        <property type="protein sequence ID" value="CAA73985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710275.2">
        <property type="nucleotide sequence ID" value="XM_705183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P87207"/>
    <dbReference type="SMR" id="P87207"/>
    <dbReference type="STRING" id="237561.P87207"/>
    <dbReference type="CAZy" id="GT15">
        <property type="family name" value="Glycosyltransferase Family 15"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="P87207">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CR_05290W_A-T">
        <property type="protein sequence ID" value="CR_05290W_A-T-p1"/>
        <property type="gene ID" value="CR_05290W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3648123"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05290WA"/>
    <dbReference type="CGD" id="CAL0000188769">
        <property type="gene designation" value="MNT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05290W_A"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_2_1"/>
    <dbReference type="InParanoid" id="P87207"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000031">
        <property type="term" value="F:mannosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000208249" description="Probable mannosyltransferase MNT3">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA73985." evidence="2" ref="1">
        <original>W</original>
        <variation>R</variation>
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA73985." evidence="2" ref="1">
        <original>S</original>
        <variation>P</variation>
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA73985." evidence="2" ref="1">
        <original>T</original>
        <variation>I</variation>
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA73985." evidence="2" ref="1">
        <original>T</original>
        <variation>I</variation>
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA73985." evidence="2" ref="1">
        <original>I</original>
        <variation>T</variation>
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA73985." evidence="2" ref="1">
        <original>RNSDV</original>
        <variation>QNSDI</variation>
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="378" mass="45322" checksum="60ECA41C81668152" modified="2017-03-15" version="2">MLWHLVFILIAILLLTFSPKIESLFKSFTINKPTKTTCYQYTTREQLKSILESDTHETNFCIEKPSISPPKTNSTLLMLCRNSDVFSVLETIQNIQDRFNDKYNYDYTFLNDVPFNYEFIYLVSSIIPHGKINFGLIPIEHWSYPSHINISLATEIRQNYANVPYGDSESYRHMCRFYSGFFYKHELVKQYQYYWRIEPGIKIYCDIDYDVFEYMIINDKKYGFVISLFEYSETIPTLWNHVVQYINDNEIKSELLPLLTNKYNWYNLCHFWSNFEIANLDIFNNDDYENFFQYLDNLGGFYYERWGDAPIHSIAIALFLQKKDIHWFENIGYYHVPYLQCPQDIDLYVKNKCTCNPDEDFTWSDLSCTNHFLNILHN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>P9WER7</accession>
    <name>RS32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Large ribosomal subunit protein eL41</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPL41</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="unpublished observations" date="2023-10">
            <authorList>
                <person name="Leibundgut M.A."/>
                <person name="Ban N."/>
            </authorList>
        </citation>
        <scope>REVISION OF SUBUNIT</scope>
        <scope>NOMENCLATURE</scope>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Component of the small ribosomal subunit (Probable) (Ref.3). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">Initially thought to be part of the large ribosomal subunit. Crystal structures show eS32/eL41 to be a small ribosomal subunit forming a bridge at the interface of the 2 subunits.</text>
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        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS32 family.</text>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PubMed" id="35613268"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
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    <sequence length="25" mass="3379" checksum="9EC629DD9ED85535" modified="2022-10-12" version="1">MRDKWRKKRVRRLKRKRRKVRARSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q59N74</accession>
    <accession>A0A1D8PNT9</accession>
    <name>RCF1_CANAL</name>
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        <recommendedName>
            <fullName>Respiratory supercomplex factor 1, mitochondrial</fullName>
        </recommendedName>
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        <name type="primary">RCF1</name>
        <name type="synonym">AIM31</name>
        <name type="ordered locus">CAALFM_C503800WA</name>
        <name type="ORF">CaO19.1114</name>
        <name type="ORF">CaO19.8711</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
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        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="84"/>
        </location>
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        <location>
            <begin position="4"/>
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        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="155" mass="18126" checksum="805F6B6B26BE205D" modified="2017-03-15" version="2">MSVRLPSSMSYGEEEEPDVLQKMWDKSKQQPFVPLGSLLTAGAVLLAARSMKRGEKLKTQRYFRYRIGFQLATLVALVGGGFYYGTETSQHKQTREDKLREKAKQREKLWIEELERRDAIIQARKQRLEESKKELRELAKQGFIEEKESNDKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P40</accession>
    <name>Q59P40_CANAL</name>
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        <submittedName>
            <fullName evidence="10">Avt1p</fullName>
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    <gene>
        <name evidence="9 10" type="primary">AVT1</name>
        <name evidence="10" type="ordered locus">CAALFM_C206330CA</name>
        <name evidence="9" type="ordered locus">orf19.12951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711488.1">
        <property type="nucleotide sequence ID" value="XM_706396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59P40"/>
    <dbReference type="STRING" id="237561.Q59P40"/>
    <dbReference type="GeneID" id="3646928"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206330CA"/>
    <dbReference type="CGD" id="CAL0000176671">
        <property type="gene designation" value="AVT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06330C_A"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_8_2_1"/>
    <dbReference type="InParanoid" id="Q59P40"/>
    <dbReference type="OMA" id="AICYTVC"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="136"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000176671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="535" mass="58824" checksum="C116F941FC0A9BC8" modified="2005-04-26" version="1">MPSPDLTDPPSAPKQRRRSFMDYGGPNSINNFASSYSRAQQYIGTSFMEQGGEYMESPPQIPSRPLHEDNEAFISSDDNSIRSDNNSNNQTEHMDFPLPPPIDWSNNSVFDETSELLPTLSRVSTKRHSFSLITGNSTAAQTIFNSINTLIGIGMLSLPLGFKMSGWLFGSLLLVVSAFLTNTTAKYLGKILYRHQELMTYGDIAYAYGGKYFSYLVTLFFVIDLFGASLTLIILFADSFTIVWPHVPALKAIIVAVVFVLSLLPLSMLSIFSLLGIISTVGIILSVFICGFLVDTSPGSLLIPATTTLLPPNPINLLFSLGIFMAPWGGHPVFPELYRDMRHPFKFTKSSNISFLVTYLLDFSIGATGYLMYGLMVDDSIVKSIMQNPNYPPIINSILCILMGILPISKLPLVTKPIITSYENIFGITAKYVKLDENGKLTDTYGPTRVFSRLLFCCVLLISALLLTSFGKLVAFLGSAICYTVCLTLPLLFYLKLNRSSVGKLEGLLIKIGIVFSITATILGTYASIGLTIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Q01</accession>
    <name>Q59Q01_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_CR06650CA</name>
        <name evidence="3" type="ordered locus">orf19.8318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711772.1">
        <property type="nucleotide sequence ID" value="XM_706680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Q01"/>
    <dbReference type="GeneID" id="3646620"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06650CA"/>
    <dbReference type="CGD" id="CAL0000181789">
        <property type="gene designation" value="orf19.8318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06650C_A"/>
    <dbReference type="HOGENOM" id="CLU_2037751_0_0_1"/>
    <dbReference type="InParanoid" id="Q59Q01"/>
    <dbReference type="OMA" id="QNDRNIH"/>
    <dbReference type="OrthoDB" id="5297016at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000181789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW31362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="125" mass="14653" checksum="D153D166209E3A09" modified="2005-04-26" version="1">MKIFTMFNPLSTTTTIIPLRKKTALLKNNSQNDRNIHFHLITFPNGISVEEYGLPIIKTLQDIENLPKFEVIRYLQGFDIEYNNNNVLSEIHLRNLLKDRLIIEMNYLNGGVKKTKWSKAKKLKH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q59R09</accession>
    <accession>A0A1D8PQD0</accession>
    <accession>Q59QY3</accession>
    <name>ATM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
            <ecNumber evidence="2">7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ATM1</name>
        <name type="ordered locus">CAALFM_C604210CA</name>
        <name type="ORF">CaO19.1077</name>
        <name type="ORF">CaO19.8678</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712090.2">
        <property type="nucleotide sequence ID" value="XM_706997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59R09"/>
    <dbReference type="SMR" id="Q59R09"/>
    <dbReference type="FunCoup" id="Q59R09">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59R09"/>
    <dbReference type="EnsemblFungi" id="C6_04210C_A-T">
        <property type="protein sequence ID" value="C6_04210C_A-T-p1"/>
        <property type="gene ID" value="C6_04210C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646284"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604210CA"/>
    <dbReference type="CGD" id="CAL0000178930">
        <property type="gene designation" value="ATM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04210C_A"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="Q59R09"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PRO" id="PR:Q59R09"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000255440" description="Iron-sulfur clusters transporter ATM1, mitochondrial">
        <location>
            <begin position="17"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="289"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="411"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="125"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="466"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q2G506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9NP58"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="750" mass="84059" checksum="894F340D6347FE7F" modified="2017-03-15" version="2" precursor="true">MFIRNVKLIKPSPVRFISPIPFSFPISRSIKISSIRYFTNKSTSNFKSTSSSSSLKSTSTSTSTSTSKTTPKTLSKPPPKVKPPIQDNDTTSSGSSSSENSESFMLKSLFKTIWPKNNLNFKIRVIIALSLLVGAKILNVQVPFYFKQIIDTMNIDWTNEVGVFSTVIGSLILAYGGARFGAVLFGELRNAIFASVAQSAIRRVAYNTFVKLLNMDLQFHLSRQTGGLTRAIDRGTKGISYVLSAMVFHIIPITLEISIVCGILTYNYGASFAAMTFVTMLAYSIFTIQTTAWRTKFRRQANNADNQAANVALDSLINYESVKIFNNELYQASKYDKALMKYQQSSVKIATSLAFLNSGQNFIFTSALTAMMYMGCQGVYTGELTVGDLVLINQLVFQLSVPLNFLGSVYRELKQSLLDMENLFQLQNQPIRIKEIPNAPPLKLNNNNNNNNNNNNNNNNSLPGEIRFENVSFGYHPDRPILNNASFTIPAGQKVAIVGPSGSGKSTILRLIFRFYDINQGRILIDGQDISKVSLESLRKLIGIVPQETPLFNDTILENIRYGRLDASDEEIYRVINQVQLNKLIDDLPDGVQTIVGERGMMISGGEKQRLAMARLLLKRAPITFFDEATSALDTHTEQALLKTIRSVFKQQHQTNVSIAHRLRTIADADKIIVLNKGQVVEEGTHWQLLNEQPNSLYAQLWNIQENLDIEKELLQGDEEEEELTEKLKLDKQELEQEAKLFNSQTFEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RP7</accession>
    <accession>A0A1D8PTG4</accession>
    <name>RM04_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MRPL4</name>
        <name type="ordered locus">CAALFM_CR07320CA</name>
        <name type="ORF">CaO19.13555</name>
        <name type="ORF">CaO19.6136</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit (mt-LSU).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712343.2">
        <property type="nucleotide sequence ID" value="XM_707250.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RP7"/>
    <dbReference type="SMR" id="Q59RP7"/>
    <dbReference type="FunCoup" id="Q59RP7">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59RP7"/>
    <dbReference type="EnsemblFungi" id="CR_07320C_A-T">
        <property type="protein sequence ID" value="CR_07320C_A-T-p1"/>
        <property type="gene ID" value="CR_07320C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3646057"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07320CA"/>
    <dbReference type="CGD" id="CAL0000187858">
        <property type="gene designation" value="orf19.13555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07320C_A"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872105_0_0_1"/>
    <dbReference type="InParanoid" id="Q59RP7"/>
    <dbReference type="OMA" id="IRTTMWR"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="PRO" id="PR:Q59RP7"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372396" description="Large ribosomal subunit protein uL29m">
        <location>
            <begin status="unknown"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="36363" checksum="0180D7D179AED0EA" modified="2017-03-15" version="2" precursor="true">MSLYSNIRTFSTRSIVLNRIKPLKFEDLTKIKLREPVVPRVANFEVSPDHPLWQFFPQGNKTKVAIRESEELDLDSREWSSAELRQKSFEDLHKIWYLTLKERNILSREVRLGESLGMGDFRQFNNVDRKLIKTQKRIKQVLLERQVAVERAQATMQDDIQKYLDDFKTRYVNCEADEVEDYHEKLVRLQYAIFGINPNLSLELLQDEETIDVNFVKGLSYIANLKVERHLKLNPQTEFELPLNGPVEELPFFLNDVEVAISQVKQLRDSGKSRMLHKIEVIPFLKQAIESHMQQEENIGGYEEEQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SM3</accession>
    <name>Q59SM3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Origin recognition complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ORC5</name>
        <name evidence="11" type="ordered locus">CAALFM_CR06960WA</name>
        <name evidence="10" type="ordered locus">orf19.9905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
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    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712659.1">
        <property type="nucleotide sequence ID" value="XM_707566.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SM3"/>
    <dbReference type="SMR" id="Q59SM3"/>
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    <dbReference type="STRING" id="237561.Q59SM3"/>
    <dbReference type="GeneID" id="3645737"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06960WA"/>
    <dbReference type="CGD" id="CAL0000191350">
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    <dbReference type="VEuPathDB" id="FungiDB:CR_06960W_A"/>
    <dbReference type="eggNOG" id="KOG2543">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
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        <property type="term" value="P:DNA replication initiation"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_16"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000191350"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="496" mass="57043" checksum="55784BE446F423ED" modified="2005-04-26" version="1">MSLTLDELTQLKKQVKERDEEIDLLNAFINKNPRLSSPCVIVHGYKSIGKTFTVTKFLKALGTNFSTINCDECVSKKILLRRCFDKIRIDSGCPKGSLNTRNDLAKYGNNGDSFSTFVSALELFVEEFDYKLEHHVLLLDRFDQCFEYVNDLLAGFTRLRESSTLLQNFTVVVIISGEDPKEIVTLSNPHVYFKVYNESQIISILQESRLCKFNINDVSDDSTESIEFYNQYVKAIVDMLYPYTGSDMSLLIDFTKRLWDPFIEPIRQGRLQITEFVKCLKEGIHLFTNEDVVSTSGVIEFKTLQWEKQVTHGGHVHDLPLHSKFFLLASYLASYGSYRNDLHKYSKVKVVKYKKRQSTKATSVTKGHMSKESIDTRLLSANYVDLERILAILSVIYRNYAPSLNHSDKDELLYMDDRIIEDEEKKESERSKFTLTRNIDLSNQIATLFSLGLLSKTNSSDILTAKVRWKCNIDWKTAEGIAKSVDFPISDFMMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q59SS7</accession>
    <name>Q59SS7_CANAL</name>
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        <submittedName>
            <fullName evidence="10">Origin recognition complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">ORC3</name>
        <name evidence="10" type="ordered locus">CAALFM_C303750CA</name>
        <name evidence="9" type="ordered locus">orf19.14204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712743.1">
        <property type="nucleotide sequence ID" value="XM_707650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59SS7"/>
    <dbReference type="SMR" id="Q59SS7"/>
    <dbReference type="FunCoup" id="Q59SS7">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59SS7"/>
    <dbReference type="GeneID" id="3645639"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303750CA"/>
    <dbReference type="CGD" id="CAL0000185041">
        <property type="gene designation" value="ORC3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03750C_A"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q59SS7"/>
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    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:nuclear origin of replication recognition complex"/>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ORC3"/>
    </dbReference>
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        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="570"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000185041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="682" mass="79275" checksum="A5BC3315488A3DC7" modified="2005-04-26" version="1">MTQRKRSSPEDDLSNSSDSELESPQLENDDDLKTHYYITPKTNSTDSSFENVYCRVTSQPKQPQKNTTPFLSLLDGNESSENVSRRFELYNQVWANQSDKIQSILNNANDELFKDLIQFVNLENLQQLSVGYVQLTTNTANNLRILQEFYQYIQRKSDYDYKLITLNSKHFTYNIKATLREVVKQFYDTCQIVEEMHRLNYDLDAIDDWFDEERLYNSRLVLVLEDTNLINNQLLNQLLKILSSYVGKWPLKIVMGLSCETVSSWINGNLTNELRIGIEGHKFKSNDNKSLGYIILNNLFLTPELTPENPLLINSTLSTIILNRFENSNNSIDALIAEIKLCYMIYFYRSPLSILIAEENPQPQELYADGLRKLSSFKKYIELKLHQGDRSVKDLLNNDKSVIKLFNESRSNFRKFKLAVMNAINIIYQLHPNKPKQKFELYKLLINHKLLNSKYLYESVKNLSKLSDSVLGKVLIGLTDNCTEILDGISDNHLIQLIKGLGELSDLRGVSDKLQNYFDNSILTTPLEYMVFHEVFSMDGGLIQEKFTKPPLFEENYENLMINLLRPNLRATIERGLDNYETYLANPLIENSVEQPLMPPTLTHLFKLYKEAPTTINLYDFYQAFKSTLDEKELSLQLSTNEDWEKLTYAWFVQNCHELMLMGILQQKPKGDFLEKAIWKGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q59UG3</accession>
    <accession>A0A1D8PSG2</accession>
    <accession>Q59UL5</accession>
    <name>ATG4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cysteine protease ATG4</fullName>
            <ecNumber>3.4.22.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG4</name>
        <name type="ordered locus">CAALFM_CR03220CA</name>
        <name type="ORF">CaO19.2401</name>
        <name type="ORF">CaO19.9938</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713234.2">
        <property type="nucleotide sequence ID" value="XM_708141.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59UG3"/>
    <dbReference type="SMR" id="Q59UG3"/>
    <dbReference type="FunCoup" id="Q59UG3">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59UG3"/>
    <dbReference type="MEROPS" id="C54.001"/>
    <dbReference type="EnsemblFungi" id="CR_03220C_A-T">
        <property type="protein sequence ID" value="CR_03220C_A-T-p1"/>
        <property type="gene ID" value="CR_03220C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645128"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03220CA"/>
    <dbReference type="CGD" id="CAL0000174445">
        <property type="gene designation" value="orf19.9938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03220C_A"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021259_5_2_1"/>
    <dbReference type="InParanoid" id="Q59UG3"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="PRO" id="PR:Q59UG3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000215858" description="Cysteine protease ATG4">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9Y4P1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="446" mass="50441" checksum="937AC463E8FCDF90" modified="2017-03-15" version="2">MNQPNPNKQPIVQSTSEQTSNEEVDTVLGRFTLFVKDLSNGLNGSQEVPPSQESVSEEAEVISRKIIVLGQTFDNFDNANDYIESKLWLSYRCGFEPIPKSIDGPQPIQFFPSIIFNRSTIYSNFANLKSLFDKENFTSDAGWGCMIRTSQNLLANTLLKLYPKNEPEIVKLFQDDTSSPFSIHNFIRVASLSPLHVKPGEWFGPNAASLSIKRLASELLQDQEIDGIKIPRVFISENSDLFDDEIRDVFAKEKNASVLILFPIRLGIDKVNSYYYNSIFHLLASKYSCGIAGGKPSSSFYFLGYEDTDLIYFDPHLPQVVETPINMDSYHTTNYNRLNISLLDPSMMIGILVTNIDEYIDFKTSCLDINNKIVHFHPHTLPVQQDSIINQSWEEVQDEEEEFINLNVSKIENEQQQEQGQSTDAPDEFIDIGNQSSSVVSVPSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59V85</accession>
    <name>Q59V85_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rpl7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">RPL7</name>
        <name evidence="5" type="ordered locus">CAALFM_CR06120WA</name>
        <name evidence="4" type="ordered locus">orf19.11348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_441054.1">
        <property type="nucleotide sequence ID" value="XM_441054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59V85"/>
    <dbReference type="SMR" id="Q59V85"/>
    <dbReference type="FunCoup" id="Q59V85">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59V85"/>
    <dbReference type="GeneID" id="6335362"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR06120WA"/>
    <dbReference type="CGD" id="CAL0000194902">
        <property type="gene designation" value="RPL7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06120W_A"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_1_0_1"/>
    <dbReference type="InParanoid" id="Q59V85"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000465">
        <property type="term" value="P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000022">
        <property type="entry name" value="Ribosome biogenesis protein RLP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF26">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="3">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000194902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW31323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="295" mass="33952" checksum="D91AC8B362B608C0" modified="2005-04-26" version="1">MAILNSNPEVLLRKRKNADRKRIEKQEQIRERQLNKNKLKKKNQNKFIRAETLVSNHKSNELERKRIKSLIKKQKQTQQQQESAAADSGDAKLLFLIRIPNHTKGLKLPSKVYKILKDLKLTSVNTGTFVKADSQTMDSLKFIAPYVLVGQPSLTSIRKLFQKRARIMVPDEEQEQEKTTNEQEAGQSEDSESETKQKIIKLDNNQLVEDKFGNDLGLICIEDLIHEISQLSDNFNSITNWLLPFQLNAPVNGWGPQAKLARLLKADENKQKISLAQDFKLQEVEDIDKIIDEQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-18" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VR3</accession>
    <accession>A0A1D8PD56</accession>
    <accession>Q59VV9</accession>
    <name>FKBP3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>FK506-binding protein 3</fullName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName>PPIase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FPR3</name>
        <name type="ordered locus">CAALFM_C103790CA</name>
        <name type="ORF">CaO19.1030</name>
        <name type="ORF">CaO19.8632</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by both FK506 and rapamycin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713635.1">
        <property type="nucleotide sequence ID" value="XM_708542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VR3"/>
    <dbReference type="SMR" id="Q59VR3"/>
    <dbReference type="BioGRID" id="1227740">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q59VR3">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VR3"/>
    <dbReference type="EnsemblFungi" id="C1_03790C_A-T">
        <property type="protein sequence ID" value="C1_03790C_A-T-p1"/>
        <property type="gene ID" value="C1_03790C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644682"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103790CA"/>
    <dbReference type="CGD" id="CAL0000196167">
        <property type="gene designation" value="orf19.8632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03790C_A"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022297_3_1_1"/>
    <dbReference type="InParanoid" id="Q59VR3"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="PRO" id="PR:Q59VR3"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000233076" description="FK506-binding protein 3">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="2">
        <location>
            <begin position="340"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="426" mass="47668" checksum="376FCD9AC644DB2E" modified="2005-04-26" version="1">MSNLTPIATYNLALQPFQPVPAIEDDFPISIRITLASLDPEAADDKAEPSSLRILKKSNSLLSDDYFEDDDDDEEEDDEEDELDDEEEEEEAEEEKSSKKSNGKKSSKKDEDEEEDDEEEDDEDNDEDDVSEYIVCTLSPKHQYQQTLDLTITPDEEVYFVVTGSYPIHLTGNYIEHPADQDEEDYDNEDEDYDDEYDLSPDEDEIIYGAPLDDEYDDEEESEEEGTPKIEEIVEEKEKVKESPKESKKRVAEESTSKKSKKAKKDEKKSVQFSKELEQGPTGSTLVEKDNKKATPTKDKKETPVKDDGDKKKKFPTKTLLGGVITEDRKIGSGATAKSGAKVGIRYIGKLKNGKVFDKNTSGKPFSFKLGKGECIKGFDLGVTGMAVGGERRVIIPPKMGYGSQALPGIPANSELTFDIKLVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VZ3</accession>
    <name>Q59VZ3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Set6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">SET6</name>
        <name evidence="3" type="ordered locus">CAALFM_C102080WA</name>
        <name evidence="2" type="ordered locus">orf19.11149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713759.1">
        <property type="nucleotide sequence ID" value="XM_708666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VZ3"/>
    <dbReference type="FunCoup" id="Q59VZ3">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VZ3"/>
    <dbReference type="GeneID" id="3644590"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102080WA"/>
    <dbReference type="CGD" id="CAL0000174725">
        <property type="gene designation" value="SET6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02080W_A"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038964_1_0_1"/>
    <dbReference type="InParanoid" id="Q59VZ3"/>
    <dbReference type="OMA" id="FRKEVCH"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000174725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="379" mass="43918" checksum="984AFD9E86EBC567" modified="2005-04-26" version="1">MAASEESTLVDEYPIKSILNQISPWFIVDETKYGGRGCFAPKVIPQHTVIHSCQTPIGSTLSKPFKKEVCSQCYTYTYGETMKFKISKTEGKHVYSLFFCSEECKSTFTHQDINRVLVENLLAVEKNYLAGLSKPEIEPMEPKNFADDYVKEWDKVASWETKLESLKPSKRQNQIFRIDDNEYLEIKYVIGVLFNMYKVHCNDHIPHFDYPNLDKNEANKVELLLFDLLYSSEFEKVKRYPYLLYSYINIYKFIKLTCTPELQAFIDSTTIRSIIGKNLSNAFGIWSEVTDPSEDKEFLGFGVYPSASFFNHSCSPNIVKTRNNSEMVFTTSKDIEIGEELCISYGNYTDEPVELRQKQLKEWFFDCACTKCQTELKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q59W37</accession>
    <name>Q59W37_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C601960WA</name>
        <name evidence="2" type="ordered locus">orf19.8305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713820.1">
        <property type="nucleotide sequence ID" value="XM_708727.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59W37"/>
    <dbReference type="GeneID" id="3644559"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601960WA"/>
    <dbReference type="CGD" id="CAL0000199372">
        <property type="gene designation" value="orf19.8305"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01960W_A"/>
    <dbReference type="eggNOG" id="ENOG502T5JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485695_0_0_1"/>
    <dbReference type="InParanoid" id="Q59W37"/>
    <dbReference type="OrthoDB" id="4075427at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="561" mass="64189" checksum="9A1BF73A27970A9C" modified="2005-04-26" version="1">MTSNKKLLKHIRTTNALSSIPPVLDILDRNDTSKLIVKYTYEIPVVLLRISDLGSAQGIIVFTDFSEIKTNTCMKYGRVPYSIAKEDYSVGGVIIPKDRLFNSSIRRDQYDTLAKMIERSVQGDPEDDGFLIAKLNFDLKIKNCKYLEGYFNHAEIATKKNLHDLFEKDLQYEFSEMLRRMKGFCEPDVYNELRVKYDFSSFEIFRKNRNRGDIELDSQLPDQKRRNFGGGIAANMLSNKIVKDSQRMNFDTQATQIHKTDFLQGPIIEEEVSNQPLNLDSQLPTVTNAVPPDPTDSYVSNAFEALNNTSSRQTGSNLLFHRPVSTRSSTTNQNTSNEGKSKGISQMVIPCTPIQSSNETNLEAPSFASVDTAAMSQDLGSQSEMVEPKIEPSNGLNLTSITVLPDWDNVTKKYLDRHENAKIRIKSIYAARNKMKSFQENVPYTLEKIKVKGMFPFHPIIIKPYARTWKITPFKIIAEDVEDKNLTLAIEISNDDEICKFFNINEIEDVVRKGQRINSQLQRLLNQKKEVLLNIKRKIRTLPNNFKYTYWTIDSPINQII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q59XM0</accession>
    <accession>A0A1D8PPL8</accession>
    <accession>Q59WR8</accession>
    <name>QDR3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS antiporter QDR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">QDR3</name>
        <name type="ordered locus">CAALFM_C601290CA</name>
        <name type="ORF">CaO19.136</name>
        <name type="ORF">CaO19.7780</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="BMC Genomics" volume="9" first="579" last="579">
            <title>MFS transportome of the human pathogenic yeast Candida albicans.</title>
            <authorList>
                <person name="Gaur M."/>
                <person name="Puri N."/>
                <person name="Manoharlal R."/>
                <person name="Rai V."/>
                <person name="Mukhopadhayay G."/>
                <person name="Choudhury D."/>
                <person name="Prasad R."/>
            </authorList>
            <dbReference type="PubMed" id="19055746"/>
            <dbReference type="DOI" id="10.1186/1471-2164-9-579"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="Biochem. J." volume="460" first="223" last="235">
            <title>Novel role of a family of major facilitator transporters in biofilm development and virulence of Candida albicans.</title>
            <authorList>
                <person name="Shah A.H."/>
                <person name="Singh A."/>
                <person name="Dhamgaye S."/>
                <person name="Chauhan N."/>
                <person name="Vandeputte P."/>
                <person name="Suneetha K.J."/>
                <person name="Kaur R."/>
                <person name="Mukherjee P.K."/>
                <person name="Chandra J."/>
                <person name="Ghannoum M.A."/>
                <person name="Sanglard D."/>
                <person name="Goswami S.K."/>
                <person name="Prasad R."/>
            </authorList>
            <dbReference type="PubMed" id="24621232"/>
            <dbReference type="DOI" id="10.1042/BJ20140010"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="5">In contrast to QDR1 and QDR2, does not accumulate in membrane rafts and shows uniform distribution at the cell membrane.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is repressed by HAP43.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to defects in biofilm architecture and attenuated virulence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714342.2">
        <property type="nucleotide sequence ID" value="XM_709249.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59XM0"/>
    <dbReference type="FunCoup" id="Q59XM0">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59XM0"/>
    <dbReference type="GlyCosmos" id="Q59XM0">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_01290C_A-T">
        <property type="protein sequence ID" value="C6_01290C_A-T-p1"/>
        <property type="gene ID" value="C6_01290C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644023"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601290CA"/>
    <dbReference type="CGD" id="CAL0000174097">
        <property type="gene designation" value="QDR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01290C_A"/>
    <dbReference type="HOGENOM" id="CLU_008455_8_5_1"/>
    <dbReference type="InParanoid" id="Q59XM0"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PRO" id="PR:Q59XM0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015565">
        <property type="term" value="F:threonine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032973">
        <property type="term" value="P:amino acid export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001765">
        <property type="term" value="P:membrane raft assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000773">
        <property type="entry name" value="Quinidine resistance"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000431601" description="MFS antiporter QDR3">
        <location>
            <begin position="1"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
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        </location>
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        </location>
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        <location>
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        <location>
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        </location>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="21592964"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="19055746"/>
        </source>
    </evidence>
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    <sequence length="697" mass="77198" checksum="1D9A55A4413F133C" modified="2017-03-15" version="2">MSHSPNLSPQISNDIIDADTTSLASTETQQNIQHSQIHPIGHHGREQSEEPQNTTKTTTTTTNKIHTTTPSVDPDLGPLRELEQDLSSLESQQEQYLSQKPTSTSIKTNKVPLRERRGLLAQIVLIPEYEDARDYPNKIKYLIVFIIAFASLAGPFGTSVMLPAIDDIVNDLNTNVSTVNVSVGIYLLSLGIFPLWWSSFSERFGRRSVYMVSFTLFVAFSIGTALSPNIAALIVLRVLQGGSSASVQAVGAGTIADLFIPQERGQAMGLYYLGPLAGPFLAPILGGAVSQAWGWRATQWLLMIISACSFVLITFFLPETLRRVDTIQVAKDLMKKSDNNGSQNEKIHDDFAGADNSSVHDIDGNPIPGTELHQVVSNLSRRSSNARSIVTYMEEQENEGPIIDPVMPSISRLTTNRSAYSQRIHQNYVTDELRKTTSNLTQSNHSQYNNNNNNDNDKWSSVKTNCYDLIIRPLHSIILLKHPPVVLVISFSAISFAAIYFFNMAISYEYARSPYNFSSVILGLMYIPNSVTYFMASIIGGKWNDRLLNRYAQKHGELVPESRLSWNIVVAIILYPMACLIFGWTIKYREFWVIPLIGTALFGFASMLVIGATVTYLVDSLPGKGATGVALNNLIRQILAAIATFIVEPLLRAIGAGVLFSIIAGILLVSSLVLLYLKKRGAFFREHYDVMDLYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0L4</accession>
    <name>Q5A0L4_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Plc2p</fullName>
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        <name evidence="2 3" type="primary">PLC2</name>
        <name evidence="3" type="ordered locus">CAALFM_C203040WA</name>
        <name evidence="2" type="ordered locus">orf19.13219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27341.1"/>
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    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SI:DKEY-266F7.9"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000198521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="295" mass="33644" checksum="A95285D90EC37F48" modified="2005-04-26" version="1">MVDYKTWLKDIDNNTRISKLSIPGTHNSAACHTALPSVQCQGASVTEQLEHGVRFLDIRVGKLFVGNDVKDLQVIHGKFPVKIPFPLKLKDTLEEVYKFLAHNSSETVIVSIKQEGSDDWDNSQDEFGKLIWDRYVNPNKDRWYLNTDIPKLGDARGKAILFRRFGVQDEQLKKQFGFSASSWTYNTTNDDRGQFVVQDFCEVNTADDLPKKIDYVKDLAKRAQDYTSKGDDKVFLNFTSASNFFDQSCWPQPIAEAMIKGNIQETFHKGVGIIVLDYAETDNWKLPEALIDTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0Z2</accession>
    <name>Q5A0Z2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alkaline dihydroceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">YDC1</name>
        <name evidence="11" type="ordered locus">CAALFM_C407050WA</name>
        <name evidence="10" type="ordered locus">orf19.10616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715413.1">
        <property type="nucleotide sequence ID" value="XM_710320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0Z2"/>
    <dbReference type="SMR" id="Q5A0Z2"/>
    <dbReference type="FunCoup" id="Q5A0Z2">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0Z2"/>
    <dbReference type="GeneID" id="3642962"/>
    <dbReference type="KEGG" id="cal:CAALFM_C407050WA"/>
    <dbReference type="CGD" id="CAL0000177800">
        <property type="gene designation" value="YDC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_07050W_A"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_3_0_1"/>
    <dbReference type="InParanoid" id="Q5A0Z2"/>
    <dbReference type="OMA" id="IMFEPLR"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Ceramidase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
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            <begin position="40"/>
            <end position="61"/>
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            <position position="25"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <position position="26"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <position position="28"/>
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        <ligand>
            <name>Ca(2+)</name>
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        <location>
            <position position="30"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <position position="39"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        <location>
            <position position="87"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <ligand>
            <name>Zn(2+)</name>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="PIRSR" id="PIRSR608901-1"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="CGD" id="CAL0000177800"/>
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            <dbReference type="EMBL" id="AOW29426.1"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="296" mass="34656" checksum="CC07662C4CBD7B19" modified="2005-04-26" version="1">MLPFAWPYPPEQKDGYWGIPTSTIDWCEENYVISTYIAEALNTTTNSVFIALATFAIYHAFHNKLEPRFIFTAFGFLLVGVGSWLFHMTLRYHFQLLDELPMIYATCIPFWSVFSEFKTPRQSILVAVGIFTAANLLTVIYLYFRNPTIHQAAYGILNGFIILRSIQLNVKYVHDKTARAQLHKTSIFGVGIFLLGYFLWNLDIHFCDFARATRREWGIPYGFVLEGHGWWHIFTGIGVYYSLVYEEYLRCFLTGTEKYFQFTWIWGLPVVYCIDKQGLERYRSVQKLAEEDKKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1F2</accession>
    <name>Q5A1F2_CANAL</name>
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        <submittedName>
            <fullName evidence="15">Sorting nexin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C406650WA</name>
        <name evidence="14" type="ordered locus">orf19.10385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
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        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <end position="392"/>
        </location>
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            <end position="33"/>
        </location>
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            <end position="278"/>
        </location>
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            <end position="615"/>
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            <begin position="16"/>
            <end position="33"/>
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    </feature>
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            <end position="85"/>
        </location>
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            <end position="114"/>
        </location>
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        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
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            <end position="188"/>
        </location>
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            <end position="203"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <end position="272"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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            <dbReference type="EMBL" id="AOW29388.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="672" mass="76155" checksum="EEFB0CB27C256707" modified="2005-04-26" version="1">MDNDELTASVWDDAVSPSNNDDFGSNGLGNSRLHNSVVAPLSNQFSSLAMDDPFANPLGFGNDDQKGFQKYAQDEDEDEEDEDDNDYNKQSSYYNAVDEQTHELKKEERKEHSNEILSKLTHGAEDSDILESSNVKSPGKISSSGALFHDKGSPLKVISADAETTKSPTRLTKIKTTKFKATRPRKFSSKINVQHMNESSTNPLGPLSVDDNKENENSESNPQADFNGESIAKEAEAPLYDINNGPDSPQKPSSIKSKRPQANESDPQSNKLEITVGDPTKVGDLTTAHVVYTIKTVNKNLDSKFFPAVESVQVSRRYRDFRWIYHQLQNNHPGRIIPPPPSKQTFIGRFNENFIENRRLSLEKMLSKINHHPLLCNDPDFVMFLTSQDFVNESKERERLSGSGASLQNSEYLDGNKDVAMSSNVAAAAATAAATSGGFMSSLFSMSTKVTEPDQYFITKKQYIDDLEYNLKQFYKTIELIGQQRLDMIGILDEIALTMSELAGLEISKVTSDLLSAFSEVELKIKDNLDRINLQDQLTLGFTIEEYLRIIGSINFVFDTRLNVYQQYHNSNQELSKKQAQLDKYTRKQQQPDKINQLNFEVDKLKQRTESFEKSFKEISETIKQELENFEYERIDDFRNSVEIFIESAIESQKEAIELYETFYERQNLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1M9</accession>
    <name>Q5A1M9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">18S rRNA (Guanine1575-N7)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">BUD23</name>
        <name evidence="13" type="ordered locus">CAALFM_C501060CA</name>
        <name evidence="12" type="ordered locus">orf19.9522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715728.1">
        <property type="nucleotide sequence ID" value="XM_710635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1M9"/>
    <dbReference type="SMR" id="Q5A1M9"/>
    <dbReference type="FunCoup" id="Q5A1M9">
        <property type="interactions" value="1020"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1M9"/>
    <dbReference type="GeneID" id="3642629"/>
    <dbReference type="KEGG" id="cal:CAALFM_C501060CA"/>
    <dbReference type="CGD" id="CAL0000183972">
        <property type="gene designation" value="BUD23"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_01060C_A"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="InParanoid" id="Q5A1M9"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000183972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="271" mass="30231" checksum="5668628A1F5E9D9F" modified="2005-04-26" version="1">MSRPEELAPPEVFYNDSESFKYTSSTRVQHIQAKMTLRALELLNLEQDSPQFLLDIGCGSGLSGEILTEEGYNWIGMDISPSMLATGLDRDVEGDLFLGDVGNGIPFRAGTFDAAISISVIQWLCNADISGADPKKRLLNFFNTLYASLKRGGKFVAQFYPKNDVQTENIMGAAKVAGFGGGLVIDDPESKRHKKYYLVLTAGMADRQINLSGAEMDAPAEQQTKGLSRKRKKAMESKKDFINRKKEIMRKRGRKVAEDSKFTGRKRRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A2A7</accession>
    <name>Q5A2A7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">PRD1</name>
        <name evidence="10" type="ordered locus">CAALFM_C105300CA</name>
        <name evidence="9" type="ordered locus">orf19.8064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715869.1">
        <property type="nucleotide sequence ID" value="XM_710776.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A2A7"/>
    <dbReference type="SMR" id="Q5A2A7"/>
    <dbReference type="FunCoup" id="Q5A2A7">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A2A7"/>
    <dbReference type="GeneID" id="3642471"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105300CA"/>
    <dbReference type="CGD" id="CAL0000179503">
        <property type="gene designation" value="PRD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05300C_A"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_2_1"/>
    <dbReference type="InParanoid" id="Q5A2A7"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="239"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000179503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="702" mass="81788" checksum="0E720F912CCBAB0B" modified="2005-04-26" version="1">MNFSYFIVILLSYVTYRFYHSNMSIDFQTIVQDQDYPLWNQSPEEVLEIANAIAASETKLFDEIAAITDPSIDNVLKPFATHYNENSFPEGQSTFYQHVSTSKELRDASTKGEEIIDNNSIEQWSRPDVYQVFQKLYDSVKNDSSLDPESKRYLEKTLISFKRNGLALPEETREKVKKLQVELNNLRVKFSKNLNEDKGFVLFSKEELEGIPEDTLNQYEKVDGKFKVTFKYPDIFPIFKHARNSNTRKTANIAYGNRCAENDPILEQIIKIRFEIAKLLGYDTFSDYVLEERLAKKKDTVLNFLADLQTKLTPIAEEELKVLRDFKKKDLETRGLEPEESFYSWDYNYYNERLLEQKYKVDHVKIAEYFPLESTVAKMLGFYEKIFDIKFVKVVKPDSASVWHEDVQQYAIYQNVKTKGKELEFMGWIYFDLHPREGKYGHAANFGLGPGYLEKDGKTRHTPITVLVCNFTKPSKDKPSLLKHDEVTTFFHELGHGIHNILSKTKYSRFHGTHVERDFVETPSQMLEYWTWSKNELKELSSHYRTGEPISDELIGQLIRTKHVNTGLFNLRQLFFGIFDMKLHTIANQKELDSLDIFKVWNDLREEVTLLPSDGNTTKGYASFGHIAGGYESGYYGYLYSLVYATDIYYTLFKDDPMNVENGIRYRDIILKPGGSKEIMDNLVELLGRKPNSEAFFQEIFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A360</accession>
    <accession>A0A1D8PTR0</accession>
    <name>SIL1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SIL1</name>
        <name type="ordered locus">CAALFM_CR08350WA</name>
        <name type="ORF">CaO19.13761</name>
        <name type="ORF">CaO19.6403</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with KAR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716242.1">
        <property type="nucleotide sequence ID" value="XM_711149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A360"/>
    <dbReference type="SMR" id="Q5A360"/>
    <dbReference type="FunCoup" id="Q5A360">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A360"/>
    <dbReference type="GlyCosmos" id="Q5A360">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CR_08350W_A-T">
        <property type="protein sequence ID" value="CR_08350W_A-T-p1"/>
        <property type="gene ID" value="CR_08350W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642082"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08350WA"/>
    <dbReference type="CGD" id="CAL0000176393">
        <property type="gene designation" value="orf19.13761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08350W_A"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034955_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A360"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="PRO" id="PR:Q5A360"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001350">
        <property type="entry name" value="ER chaperone/ER translocation nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF34">
        <property type="entry name" value="NUCLEOTIDE EXCHANGE FACTOR SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00014">
        <property type="entry name" value="ER_TARGET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000223360" description="Nucleotide exchange factor SIL1">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Prevents secretion from ER" evidence="3">
        <location>
            <begin position="411"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="414" mass="47067" checksum="E907BBD67BBC2E3C" modified="2005-04-26" version="1" precursor="true">MKFSVLVLLASYLVGVNSSIVDTSEELICPDPENPLDCYPKLFVPTNEWQTIKPGQDIPPGLHVRLNIDTLEKEAKLMSADEKDEPVQEVVVGGELQDHSREAITENLQKLHESKHPEVKQEHAHRTKVSQGDLSNFDAACSEIESFKPHESDVERLHLALDTLEELSHDIEFGVKLTSDKAIFQSLVNIANGASDPKITEKVYRVMGSSLRNNPEAISNILTNFDKSYVDNLFEQLANENDVLQKRILGIIQALVQNSHFVRQYFSFDHSSGLNDLIAIFPKLGPNSKSRASNILEDLQLFPVTNDRRSLEDQDPESQVSKFIQNSFVGNKLDEKNFKSYFDQLVNLHQSNKSLRPSGDFLNWLAEEVESRKENKKRDDYSQEDKDFDEYMLRARHEVFGNPMGLRKAIADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A396</accession>
    <name>Q5A396_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">RIO2</name>
        <name evidence="18" type="ordered locus">CAALFM_CR08100CA</name>
        <name evidence="17" type="ordered locus">orf19.13726</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716210.1">
        <property type="nucleotide sequence ID" value="XM_711117.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A396"/>
    <dbReference type="SMR" id="Q5A396"/>
    <dbReference type="FunCoup" id="Q5A396">
        <property type="interactions" value="1309"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A396"/>
    <dbReference type="GeneID" id="3642066"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR08100CA"/>
    <dbReference type="CGD" id="CAL0000193362">
        <property type="gene designation" value="RIO2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_08100C_A"/>
    <dbReference type="eggNOG" id="KOG2268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A396"/>
    <dbReference type="OMA" id="MIHHENT"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046830">
        <property type="term" value="P:positive regulation of RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="99"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="385"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="386"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0000193362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW31495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="467" mass="54396" checksum="9D72593567F43491" modified="2005-04-26" version="1">MHPKKKKKKKKKNCKDISYSLSHLSSSSEHTPIMKLDTSHMRYLTSDDFRVLQAIELGSRNHELVPTQMIHSIGGLKSPSATNRAIGDIAKLKLISRLRNAKYDGFRLSYNGYDYLALKSMLNRNTLYSVGTTIGVGKESDIYSVSDPEGVQKVLKIHRLGRTSFKTVKNNRDYLKNKQTSNWMYLSRLAAAKEYQFMEVLYNNGFNVPQPFDYSRHCVMMEWIKGIPMKHLRQHKNYKKLYSDLMGFIVRLAKAGLIHCDFNEFNILIRDDTDGHEFDFVVIDFPQCVSIEHPDAKEYFDRDVQGIRDFFSKKFRYNPQHDPTMFDTDGYGDGYKYAYPNFKRDVIREKSLDVEVQASGYAKKKTGNREDKDLEKAVLGMRIKVDEDDDLSEIDDDEDVATEDEEEDEEEEEDEEEDEEEEEELFEDEEEFDEQAEAEENEKIIEALSKGDMKLKMDKLGNYILDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3J1</accession>
    <accession>A0A1D8PF91</accession>
    <name>RM51_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>54S ribosomal protein L51, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MRPL51</name>
        <name type="ordered locus">CAALFM_C111880WA</name>
        <name type="ORF">CaO19.12744</name>
        <name type="ORF">CaO19.5279</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. Also has an extraribosomal function, being essential for mitochondrial genome integrity. May interact with MHR1 to take part in the mtDNA repair mechanism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit (mt-LSU).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716348.1">
        <property type="nucleotide sequence ID" value="XM_711255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3J1"/>
    <dbReference type="SMR" id="Q5A3J1"/>
    <dbReference type="FunCoup" id="Q5A3J1">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A3J1"/>
    <dbReference type="EnsemblFungi" id="C1_11880W_A-T">
        <property type="protein sequence ID" value="C1_11880W_A-T-p1"/>
        <property type="gene ID" value="C1_11880W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642007"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111880WA"/>
    <dbReference type="CGD" id="CAL0000189507">
        <property type="gene designation" value="orf19.12744"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11880W_A"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117700_1_1_1"/>
    <dbReference type="InParanoid" id="Q5A3J1"/>
    <dbReference type="OMA" id="ISKWIDL"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="PRO" id="PR:Q5A3J1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000372635" description="Large ribosomal subunit protein mL43">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="140" mass="16072" checksum="861D8F32FB8AF730" modified="2005-04-26" version="1">MPIKAIPKVSIARNGIGAFVNPCHRITVQYCNWGGSSTHLRELLTNGGLNNYAKSKPDIFFEIKQLRGHPKLIFHYNNNVTKEVEIKNIKQNEIIKTLTEYSQRSGNELFKFNHKVKSINDSVRGIWSPLQVPKGYRHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A473</accession>
    <name>Q5A473_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gvp36p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">GVP36</name>
        <name evidence="2" type="ordered locus">CAALFM_C405550CA</name>
        <name evidence="1" type="ordered locus">orf19.8821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
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    <sequence length="321" mass="36167" checksum="77AAC7599AEB0814" modified="2005-04-26" version="1">MSFNFSNFTKDLKSFGDKISTEFNKEVVPLAQRTSRLVQEKMGNIKQDDISQLPSEYIELANKCNNIEQLYKNVLKITTNYENESYDYPTNVQESFTEFGKNITTRVSNVAKATTTAEAQAALINPNTGEFKAPKTLYHALSRATDASILTSDKSQDPLIKGLDLYSSNLNKIANARLGQDQLIKSKFNKPLLTTLRSLISQSNNIQKKVEDKRIDYDLTRSNLASCTNPQKEPKLRVDMENAEDEFANTVEDAINIMQNVLENAKPLEEFLELIKAQLAYHKLATELLDGMVKDFEELIDEQHKLSGSATSGRESGDFDI</sequence>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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            <end position="114"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A934</accession>
    <name>Q5A934_CANAL</name>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
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                <person name="Magee P.T."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="12 13" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW25807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Zinc finger protein ZPR1"/>
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        <property type="entry name" value="Znf_ZPR1"/>
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    </dbReference>
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        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
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        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
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        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="60"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="316"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000194324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW25807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="509" mass="57020" checksum="23BB96FDE2B93715" modified="2005-04-26" version="1">MSEEGAHIDKKAKIEDTDMSEESNQQVFSTVGEQAQEVDNAIKQTGAADAEGHPVQEVESLCMNCHKNGVTRMLLTRIPYFREVIIMSFECPHCGFKNSEIQPAAQIAEKGARYVLKVENKKDFNRQIVKSETATVKFTELDIEIPPKRGQLINVEGILQEMIDDLESDQPQRQKVQPEVYEKIDQVISKIKSFINCDPNTVPLTVTVDDPAGNSWIEYVPGEPTHKWAMYEYNRTAEQNVFLGLISADDVAQHRQAELANKKQATDSNISSNLNKEQSQSQSQSQEEHSNPHTTGFKSDASEIENFSNEVQTFAATCSSCYKPCETHMKTVNIPHFKDVILMSTVCDHCGYKSNEVKTGGAIPEKGKRITLKVTDPEDLARDILKSETCGLNIPELNLDLTPGTLGGRFTTIEGLLTQVLEELHSRVFTQTSDSMDDETKTRWTGFFARLQDAIDGKIGFTIVMEDPLASSYIQNVYAPDNDPNMTIEEFERTFDQNEGLGLNDIKTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A940</accession>
    <accession>A0A1D8PCE8</accession>
    <name>MBF1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MBF1</name>
        <name type="ordered locus">CAALFM_C101060WA</name>
        <name type="ORF">CaO19.10804</name>
        <name type="ORF">CaO19.3294</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718117.1">
        <property type="nucleotide sequence ID" value="XM_713024.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A940"/>
    <dbReference type="SMR" id="Q5A940"/>
    <dbReference type="FunCoup" id="Q5A940">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A940"/>
    <dbReference type="EnsemblFungi" id="C1_01060W_A-T">
        <property type="protein sequence ID" value="C1_01060W_A-T-p1"/>
        <property type="gene ID" value="C1_01060W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640171"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101060WA"/>
    <dbReference type="CGD" id="CAL0000194672">
        <property type="gene designation" value="MBF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01060W_A"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A940"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="PRO" id="PR:Q5A940"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000149803" description="Multiprotein-bridging factor 1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O14467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="151" mass="16292" checksum="828EB4ACBD49B48F" modified="2005-04-26" version="1">MSSDWDSVTIIGQKARVGGGGPRENVAKTSSQLNAARRAGLVVGTEKKYGTANTKSNPEGQRLTKLDATDDVVAVKKVDVSVGKAIQQARQEKKLTQKELATKVNEKPNVINDYEAGRAIPNQQLLAKLERALGVKLRGKNIGEPLFAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A943</accession>
    <name>Q5A943_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein-arginine omega-N methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">HMT1</name>
        <name evidence="7" type="ordered locus">CAALFM_C101030WA</name>
        <name evidence="6" type="ordered locus">orf19.10801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718114.1">
        <property type="nucleotide sequence ID" value="XM_713021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A943"/>
    <dbReference type="SMR" id="Q5A943"/>
    <dbReference type="FunCoup" id="Q5A943">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A943"/>
    <dbReference type="GeneID" id="3640182"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101030WA"/>
    <dbReference type="CGD" id="CAL0000187520">
        <property type="gene designation" value="HMT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01030W_A"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="InParanoid" id="Q5A943"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:histone methyltransferase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of termination of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="159"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000187520"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW25799.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="339" mass="39313" checksum="82E5BBABB53CBE2A" modified="2005-04-26" version="1">MSESATDKSQLSKFEQHYFSSYDHFGIHEEMLKDTSRTLSYRNAMYRNKDLFKDKIVLDVGCGTGILSMFAVKAGAKHVYSVDMSSIIDKAKEIVELNGFSDKITLLQGKLEDINLPVDKVDIIISEWMGYFLLYESMLDTVLYARDRYLVEGGLIFPDKCQMYIAGIEDAQYKDEKIHYWEDVYGFDYTPFIKTAMEEPLVDTVNNQSLITKGTQFFEFDINTVTKEQLSIKRKFELQAIDNDYCHAFIVYWDAVFPGKQRVILPTGPMHQYTHWKQTVFYMDQVLDLKKGDTINGEITAVPSKINPRELDIDISWEVKTQANDKSRELKGGYTYFLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAU5</accession>
    <accession>A0A1D8PDZ0</accession>
    <name>ATC1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Cell wall acid trehalase ATC1</fullName>
            <ecNumber>3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Alpha,alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATC1</name>
        <name type="synonym">ATH1</name>
        <name type="ordered locus">CAALFM_C106940CA</name>
        <name type="ORF">CaO19.13595</name>
        <name type="ORF">CaO19.6214</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1975" name="Physiol. Chem. Phys." volume="7" first="369" last="380">
            <title>Trehalose and glycogen levels during the initial stages of growth of Candida albicans.</title>
            <authorList>
                <person name="Arnold W.N."/>
                <person name="McLellan M.N."/>
            </authorList>
            <dbReference type="PubMed" id="1103165"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Microbiology" volume="153" first="1372" last="1381">
            <title>Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress.</title>
            <authorList>
                <person name="Pedreno Y."/>
                <person name="Gonzalez-Parraga P."/>
                <person name="Martinez-Esparza M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
                <person name="Arguelles J.C."/>
            </authorList>
            <dbReference type="PubMed" id="17464051"/>
            <dbReference type="DOI" id="10.1099/mic.0.2006/003921-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1995" name="Exp. Mycol." volume="19" first="178" last="185">
            <title>Differential extraction of N-acetylglucosaminidase and trehalase from the cell envelope of Candida albicans.</title>
            <authorList>
                <person name="Molloy C."/>
                <person name="Shepherd M.G."/>
                <person name="Sullivan P.A."/>
            </authorList>
            <dbReference type="PubMed" id="7553268"/>
            <dbReference type="DOI" id="10.1006/emyc.1995.1022"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="40852" last="40860">
            <title>The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans.</title>
            <authorList>
                <person name="Pedreno Y."/>
                <person name="Maicas S."/>
                <person name="Arguelles J.C."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="15252058"/>
            <dbReference type="DOI" id="10.1074/jbc.M400216200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="Biochem. Biophys. Res. Commun." volume="383" first="98" last="102">
            <title>On the biochemical classification of yeast trehalases: Candida albicans contains two enzymes with mixed features of neutral and acid trehalase activities.</title>
            <authorList>
                <person name="Sanchez-Fresneda R."/>
                <person name="Gonzalez-Parraga P."/>
                <person name="Esteban O."/>
                <person name="Laforet L."/>
                <person name="Valentin E."/>
                <person name="Arguelles J.C."/>
            </authorList>
            <dbReference type="PubMed" id="19336219"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2009.03.134"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="25154" last="25170">
            <title>Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.</title>
            <authorList>
                <person name="Singh R.P."/>
                <person name="Prasad H.K."/>
                <person name="Sinha I."/>
                <person name="Agarwal N."/>
                <person name="Natarajan K."/>
            </authorList>
            <dbReference type="PubMed" id="21592964"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.233569"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5 6 8">Cell wall acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source. Plays a role in dimorphic conversion and virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4 8">Secreted</location>
            <location evidence="3 4 8">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6 7">Expression is repressed by glucose and by HAP43.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Lacks acid trehalase activity and decreases hypha formation and infectivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718804.2">
        <property type="nucleotide sequence ID" value="XM_713711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AAU5"/>
    <dbReference type="SMR" id="Q5AAU5"/>
    <dbReference type="FunCoup" id="Q5AAU5">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AAU5"/>
    <dbReference type="GlyCosmos" id="Q5AAU5">
        <property type="glycosylation" value="21 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_06940C_A-T">
        <property type="protein sequence ID" value="C1_06940C_A-T-p1"/>
        <property type="gene ID" value="C1_06940C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639570"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106940CA"/>
    <dbReference type="CGD" id="CAL0000186706">
        <property type="gene designation" value="ATC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06940C_A"/>
    <dbReference type="eggNOG" id="KOG4125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AAU5"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="BRENDA" id="3.2.1.28">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="PRO" id="PR:Q5AAU5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030287">
        <property type="term" value="C:cell wall-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015771">
        <property type="term" value="P:trehalose transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.40:FF:000003">
        <property type="entry name" value="Acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000428633" description="Cell wall acid trehalase ATC1">
        <location>
            <begin position="55"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="478"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="676"/>
            <end position="677"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="17"/>
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    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="350"/>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="532"/>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="904"/>
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    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="922"/>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
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            <position position="1037"/>
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    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="D6XZ22"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="1103165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="21592964"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="7553268"/>
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    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="1078" mass="120236" checksum="2D08E9D5CD11FC24" modified="2017-04-12" version="2" precursor="true">MAANSSFFLADNCAPHNQSFIQFCIHAASKKKGRIALMCLANLFLLFSFHLLYARFCSGFPYVVPSTARSTNQIFHTNLEQLVNSPENKQIFSQLKFSDQAFYDPHDNVVGTTEFPVFNQYQRQPYVANGYIGSRIPNLGQGFTYDQLTNSSTANDDDLLNGWPLFNKRYSGAFVAGFYDLQKNTTGTNFAELLENGYESVIAAVPQWTALSLSVEILGKKYTLDPSLEHEAIGDITNYVQNMSLSDGIVTTQFTWLNTFDVKYEILAHRENINLGLVNMQVYNPGNESVQVIVSDVLDFNSSQRCQLNQISHDKNGIYVTFHPQGLSYIDGAIYSTLSANGQITREQTNETVFQNVELTIEPHSCVQVAKYVGIATTDLDPDSFKTADDVLKFARKVSQNKKHGDATQLVNSHRSAWSKIIQDAPLVTFPSDSLLNLGARASIFHLLANTRPNAEGVTGALGVSGLSSDSYGGMVFWDTDLWMLNGILPFAPDHIKSFINYRVHLHQQAIDNVPRGYQGAVYPWTSGRFGNCTGTGPCLDYEYHINMAVAMASWQLYISGAADDTFLESVAYPIINDAASFLAEYVVHYNDTLGKYTTKNLTDPDEFANHVDNGAYTNTGIVLVMRWAQIAGSILGKQVPKIYHDIETAMFLPTAENTQNITLEYSGMNSSVGIKQADVIMMTYPLENELIDQDQAYINMEFYSMKQVGYGPAMTFPIFSIVASNLAFTGCASQSYLHKAIQPFLRGPFAQFAEQNNDDYLTNGGTHPAFPFLTAHGGFLQAILQGLTGMRFDYTFENNKLQRLLKLDPIALPCLGEGVRFDSIKYDNHTLSMAINETHFTIKNKGKTTPNARNYVTILLAERNAMHGKYTINDEDEQSFPLFETSESFPDSISECNKAGFFNITEGAYGDVSISINDGDNTTSWQAKYNDTTGKVLVDLKSFRNISSGTFIWGDKPPKRVKVSKYSGSSFTAVTDFFAQVDFGNELFNEYKYANPEGKLHNQSDVFEEVYSGDVKISAPFDPEEYFQVWVPTRHNITEVAVNLQTRFLLIEVDEIHNTEAIDGDYGGAKLAEVVFY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABR2</accession>
    <accession>A0A1D8PCC5</accession>
    <accession>Q5ABF5</accession>
    <name>GEM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial Rho GTPase 1</fullName>
            <ecNumber>3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GTPase EF-hand protein of mitochondria 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GEM1</name>
        <name type="ordered locus">CAALFM_C100890WA</name>
        <name type="ORF">CaO19.13437</name>
        <name type="ORF">CaO19.6016</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_713885.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABR2"/>
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        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABR2"/>
    <dbReference type="EnsemblFungi" id="C1_00890W_A-T">
        <property type="protein sequence ID" value="C1_00890W_A-T-p1"/>
        <property type="gene ID" value="C1_00890W_A"/>
    </dbReference>
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        <property type="gene designation" value="GEM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00890W_A"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="InParanoid" id="Q5ABR2"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="PRO" id="PR:Q5ABR2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitochondrion inheritance"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900428">
        <property type="term" value="P:regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
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    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000239332" description="Mitochondrial Rho GTPase 1">
        <location>
            <begin position="1"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Anchor for type IV membrane protein" evidence="2">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="714"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Miro 1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand 1" evidence="3">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand 2" evidence="3">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Miro 2" evidence="4">
        <location>
            <begin position="505"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="167"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="257"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="550"/>
            <end position="554"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="620"/>
            <end position="623"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P39722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="716" mass="81157" checksum="63AFA5AC93C4E19E" modified="2017-04-12" version="3">MSPDAIRVVVCGDDAVGKSSLITSLIKETIIEPQTNNVLPPITISRNDYIESSQEYLNDQDHHHHHQSSPSTMKNKRKHNNKRERERERESSINNVQPNEISEYIPNITTIIDTSSSDMTNLQKELKRADVIWLVYSDHYTYERISLHWMPLFRSMGVNLPIILCANKSDLFPKSKSNLKSTNSDEFVPLINEFKEIEAGVRCSAKNNYNVVEAFYLCQRAVTHPISPIFDAKEGNLKPGAIKPLKRIFWLSDTDQDGYLNFEELSELHKKCFGIEASKSDYEEIVNLIDQKILPSYNTTIETQTPPQQQHLATSAGTPNGTTTTTSKGISEDGFILLNKIYAESGRHETVWCILRAYHYTNSLSLSDKFLYPRLDVNPHSSVELSPTGYKFFVDLFIKFDKDNDGGLNEDELNTLFRSTPGIPKLWVESNFPSSIVCNEEGYVTLQGWLAQWNLTTFLSYKTTLEYLAYLGFDEGNSTKALKVTKPRKIRQKNGKTYRNAVNDRNVFNCFIVGAPKAGKSSLLESFLHGSYSDIYSPTIQPRLVVKDIELRGGKQCYLILEELGELEPAILENKSRLDQCDVICYAYDSSDPESFQYLVELREKHGHLLDEVPAVFVALKADLDKQQQRCDVQPENYTRDLFLNSPLHVSLAWNSSLHEMFIQLVDAAKTPSSATPGIELEVSVDQDDIKHIIMTGAAIAVVGLVSIWVLNSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADQ1</accession>
    <name>Q5ADQ1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C307100CA</name>
        <name evidence="6" type="ordered locus">orf19.14082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719886.1">
        <property type="nucleotide sequence ID" value="XM_714793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADQ1"/>
    <dbReference type="SMR" id="Q5ADQ1"/>
    <dbReference type="FunCoup" id="Q5ADQ1">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADQ1"/>
    <dbReference type="GeneID" id="3638443"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307100CA"/>
    <dbReference type="CGD" id="CAL0000193463">
        <property type="gene designation" value="orf19.14082"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07100C_A"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016304_6_3_1"/>
    <dbReference type="InParanoid" id="Q5ADQ1"/>
    <dbReference type="OMA" id="PHELPQV"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000463">
        <property type="entry name" value="Nuclear acid binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="138"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="254"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="521"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="726"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="784"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000193463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW28713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="887" mass="97215" checksum="E71E6C85209C6F77" modified="2005-04-26" version="1">MGTYIPNGKDECHPGTTTTTSTSTSTSTNYDNTNTNSNSNSNSNSNSNPDPNSLSTFTTTSPQHQQHIQESVTVTTPTSKVTINPHTTSSIASQQHQQEQELLSGYTVPNPPISTQQSTAIAADQESISGSELDNKPRTLWMGDLDPWLDENAIQDLWWSILQKKVVVKIIKPKNMKPDINFQGLTNSGYCFVEFESFEDAQHALSLNGQLLPDIAMPSQSNFPNNPDNQKKYFRLNWASGATLSAPIVQTPEYSLFVGDLSASTTEAHLLAFFQKNFPNSIKTVRVMTDPISGKSRCFGFVRFTEESERQRALIEMNGAWFAGRPLRVALATPRNVARRFNNRRFSPQHQQYQHQQQQQQQQHQHQHQHQHQEQQQHQEQQQHHHQSVFSSYGGGPNMHIGGGEYFDGDPNLSPLPQTGAPTVPPELMFMPPMGPNGQLGGSPVYGYYGQTSGSGGGGYGGPELEGFSLDILQSPNLVQPMLGQQQFQHQPQYQNQLQLQHQHQHQHLQQGQQFVDPNNTTVFVGGLSSDVSEPTLHTLFKPFGLIQQVKIPPGKNCGFVKYSNREEAEEAIAAMQGFVIGGNRVRLSWGRVSVSNKKYQQQQQQQVAQVAQLQVQAALSMGMDPASAIAAAAAAAAAAATASGGGGGSGGYPPNIPLQHRQVVPPPPTSSSSVVHPAPPPPPSTSMSAMNLPPPIHGMNMNMNMNIPILPHIPQYQNIPYQSHFVSDDGRESSGGGGSGHNGDSNQGITSSSFLSNNGGRNNGDNDQVEQDDLTQAMDKMNLNSEQDDGNDDGAEYGYMMNPGFGSYGVSSTQQQQQQQQRQQQQRQQSYQQLIHDDYDQEGDKTTTKDEQGSGSDDSTGKKTKDDDDEVKDNENENVKSTHDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGY0</accession>
    <accession>Q3MPH5</accession>
    <name>Q5AGY0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ordered locus">CAALFM_C701660CA</name>
        <name evidence="21" type="ordered locus">orf19.13911</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Cytoplasmic vesicle</location>
            <location evidence="1 15">COPII-coated vesicle membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
            <orientation evidence="2 15">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Golgi apparatus membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721394.1">
        <property type="nucleotide sequence ID" value="XM_716301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGY0"/>
    <dbReference type="SMR" id="Q5AGY0"/>
    <dbReference type="STRING" id="237561.Q5AGY0"/>
    <dbReference type="GeneID" id="3636983"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701660CA"/>
    <dbReference type="CGD" id="CAL0000187171">
        <property type="gene designation" value="orf19.13911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01660C_A"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008658_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AGY0"/>
    <dbReference type="OMA" id="LFHGERE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="17">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="120"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="20">
        <location>
            <begin position="432"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="19">
        <location>
            <begin position="548"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="16">
        <location>
            <begin position="678"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0000187171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AOW30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="815" mass="91460" checksum="D7FD1800E80F5B4E" modified="2005-04-26" version="1">MDFETREDNDGVRLSWTSLPKSKLQHQRNVIPMGALYTPLNNKTSISVLDQNCIISCRTCRAVLNPYSPINNSLWTCQICNSSNQLPAMVDSEGQPCYPPNLNPELTTVEYKTGRSSALPPIFFYVVDTIFENDDIESAFQQLKESLTVSLSLLPEDALVGFISFGKHVRIHDLGSNDNLSYTFNGNKQYTLEQLQSSLGLMSSGLSTAGLKQAKDNNGYDQLIGNIGKRFLQPVNIAEYQLTRIIETLVPDRFPHNEYSERPERATGAAINVASLLLKTILNNSHHLTGGHLMVFISGVCTFGPGKIVDKLLKEPLRSHHDIIKAQTTTIQTPSTSHVAKSDINLFKQAKKFYEGITKTLVTLGLSCDFFIGSYDQVGLYEMDEVCYKTGGSVVLSDSFSTAIFKQSFIRFFKKQEEDEQDGENSEYLDMGFNATLEVKTGVDLKIEGLIGNATSLPFNKTVPANERMISTNIVGEGKTNSWKLCNANPQSTYALYFEKLDSVAAATTIQFLFHYQHPSGEMRLRVTTIPVNIIADSDNINLELGFDQETALVLVARDSINKLQPGNTKVATTASIVKQLDNTLIDFCTRFAVYTAGQIESFRLAQTFSLFPQFLYHLRRSPFINVFNSSPDETSYVRHVFMHEDTANSLLMIQPTLLSYDVNTWGSLVDETTGETINEPEPVLLDSLSLGRSKILLLDTFFQILIYHGAQVAEWRKAGYHEQEEYQYFKEFLEAPKREAMMLLMDRFPLPRFIDCDEGGSQARFLMAKLNPSTSYATNVNHLYGIGDRSDVFTDDTNLQSFMDHIQRVVTAKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI71</accession>
    <accession>A0A1D8PCV4</accession>
    <accession>O94027</accession>
    <name>ATG17_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG17</name>
        <name type="ordered locus">CAALFM_C102910CA</name>
        <name type="ORF">Ca49C10.13</name>
        <name type="ORF">CaO19.10499</name>
        <name type="ORF">CaO19.2982</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL033497">
        <property type="protein sequence ID" value="CAA21977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T52157">
        <property type="entry name" value="T52157"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721480.1">
        <property type="nucleotide sequence ID" value="XM_716387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI71"/>
    <dbReference type="SMR" id="Q5AI71"/>
    <dbReference type="FunCoup" id="Q5AI71">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AI71"/>
    <dbReference type="EnsemblFungi" id="C1_02910C_A-T">
        <property type="protein sequence ID" value="C1_02910C_A-T-p1"/>
        <property type="gene ID" value="C1_02910C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636829"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102910CA"/>
    <dbReference type="CGD" id="CAL0000200723">
        <property type="gene designation" value="ATG17"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02910C_A"/>
    <dbReference type="eggNOG" id="ENOG502RW77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565132_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AI71"/>
    <dbReference type="OMA" id="TNHFDQC"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="PRO" id="PR:Q5AI71"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000124557" description="Autophagy-related protein 17">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21977." evidence="2" ref="1">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="476" mass="55407" checksum="1AA5B5176E1CCA62" modified="2005-04-26" version="1">MTNEINSATVTQDEVIKWSREAQSTLEKTQKICTDAQSSMQKTAQELTILIPDKLQAIEFLFKSYREQYDSILKQIETTKIYLHTNIDKVFNDIKDLLDPSLARLNNILLELKKTRVPSIVVEGTSEGKTLFDFTSIQSINLLKENIGIFKSNCSKIKNLLDLEVKEKLNIEQDRMNSRWNKSVKMYDLIAPLQLELRALIHGASNESNSFMGTILRENQALENELVSILEMQTNHFDQCMKAVELISSGNGCDMNLGVLKNDAQELPEVFKELTTIYDIILRNEERSKKFLATHMPNIEKISDIVKEELAVFRKFKTEEIPRYTFLIAECENKLKECSMPVKSDQSPSQVYTQTLQELTEHYVKFINIYKTKYLAELHHQQFTYPRKFLKKLTEFLNEDIYRIQIEESERRRQWTSRYGEFIPSEFKLPGEHELPVIVQIITEGLEYIQKEDGQEEEPNIGNEKELMDMITGSNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AK94</accession>
    <accession>A0A1D8PNY7</accession>
    <name>RNY1A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Ribonuclease T2-like 1-A</fullName>
            <shortName>RNase T2-like A</shortName>
            <ecNumber>4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RNY1-A</name>
        <name type="ordered locus">CAALFM_C504400WA</name>
        <name type="ORF">CaO19.11408</name>
        <name type="ORF">CaO19.3926</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68052"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="4.6.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Vacuole lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Is released from the vacuole to the cytoplasm during stress conditions like oxidative stress or stationary phase stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AK94"/>
    <dbReference type="SMR" id="Q5AK94"/>
    <dbReference type="FunCoup" id="Q5AK94">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AK94"/>
    <dbReference type="GlyCosmos" id="Q5AK94">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C5_04400W_A-T">
        <property type="protein sequence ID" value="C5_04400W_A-T-p1"/>
        <property type="gene ID" value="C5_04400W_A"/>
    </dbReference>
    <dbReference type="KEGG" id="cal:CAALFM_C504400WA"/>
    <dbReference type="CGD" id="CAL0000196842">
        <property type="gene designation" value="RNY11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04400W_A"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AK94"/>
    <dbReference type="OMA" id="HESLWIH"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="PRO" id="PR:Q5AK94"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043251" description="Ribonuclease T2-like 1-A">
        <location>
            <begin position="18"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="42"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="399" mass="42733" checksum="CBE909B5994F7E03" modified="2017-05-10" version="2" precursor="true">MLSILSIAALLIATVQAADFSSSCPIDSPISCSSNGDTSNSCCYENPGGIILFTQFWDYNPASGPADSFTIHSIWNDYCSGGYPQFCDTSLEIDSTGSTIESIVVDQFGDQTLYDNMNKYWTDINGNNKKFWAHEFNKHGTCLNTLNPSCYSNYKQNENVYDYYSLVYQLFQKLPTYQWLVSAGIKPSTTATYTLSQIQSALKSKFGAEVYIACDSNNAINEVWYFYNIKGSILQQNYLPIDTVSKTNCPSSGIKFPPKGNSGANTLTTKTTGTTTSGSGSTSVPATSYINLTGKSGCLISNGKYYTSGTCATYHFNAGSSGNTQITSSKGNCGIDSSNQFTCSSSTSATDFQVSGGSIGYNGNFDWCLGAVTGSGSTAQTSVKLSDGSCSSFKLTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKW5</accession>
    <name>Q5AKW5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C113750CA</name>
        <name evidence="3" type="ordered locus">orf19.12479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722216.1">
        <property type="nucleotide sequence ID" value="XM_717123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKW5"/>
    <dbReference type="GeneID" id="3636137"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113750CA"/>
    <dbReference type="CGD" id="CAL0000179951">
        <property type="gene designation" value="orf19.12479"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13750C_A"/>
    <dbReference type="eggNOG" id="ENOG502SX3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119129_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AKW5"/>
    <dbReference type="OMA" id="PNWKKAP"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000179951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="23171" checksum="8F1A3C9AF91EA5F7" modified="2005-04-26" version="1">MENNDSLYFTNLKHRQQQQPLLLLLTGLIQIMTSDKPSFHKEGKSTIKIVHDNNKNNNTKQHKRPITPKDISSQSQKVKDSPFVEELVLTGRPNWKKAPQQIKQRYKGIYLILLSIPIMGITTFEIIRRLEGKSTKKIQQGERLSNGINRDFDEQEKIKVEKESIMYKIFGKDFFLDGFTSKTIKSNQEKKERKEKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKX1</accession>
    <name>Q5AKX1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">GCV3</name>
        <name evidence="8" type="ordered locus">CAALFM_C113680CA</name>
        <name evidence="7" type="ordered locus">orf19.12473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722210.1">
        <property type="nucleotide sequence ID" value="XM_717117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKX1"/>
    <dbReference type="SMR" id="Q5AKX1"/>
    <dbReference type="FunCoup" id="Q5AKX1">
        <property type="interactions" value="938"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AKX1"/>
    <dbReference type="GeneID" id="3636194"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113680CA"/>
    <dbReference type="CGD" id="CAL0000189722">
        <property type="gene designation" value="GCV3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13680C_A"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AKX1"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000189722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="177" mass="20053" checksum="28A88CFD624B0F48" modified="2005-04-26" version="1">MIRTLLRPTSLRLVTPTFRSFSTFSTRFQLIDKDSHAYKYLYEKTPVVTKFTEDHEWVHLYDDDSAFVGITQYAAQALGDVTFVDLPEVGDHLELNETLGSVESVKSSADVYSPVDGEVVGVNLKLESEPGILNHDPTKGGWIVHIKLDDPTQVTKSETLMSEEQYKKFLEEEEEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALL6</accession>
    <name>Q5ALL6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C202390WA</name>
        <name evidence="2" type="ordered locus">orf19.9135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="98"/>
            <end position="109"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000187458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="180" mass="19757" checksum="C810BF70E2A76264" modified="2005-04-26" version="1">MSQVNLLEFQDYLLYSESLNILIESEFSSMSLDTTAFQPSPTKAPEASMDSGTIPKRSPARLFQRWISSSSSSKDKPVYAEKALLKKQNIAPEPIKITKQQVPAKQIGTSEPSSPLSVASSHDNSCSDSSAASIFSDSKNNNSMQMLLTDDIEDILEDIDDAEIYDAEKVTITYISSKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALU0</accession>
    <name>Q5ALU0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C201750CA</name>
        <name evidence="2" type="ordered locus">orf19.9061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW27221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_717442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALU0"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C201750CA"/>
    <dbReference type="CGD" id="CAL0000185912">
        <property type="gene designation" value="orf19.9061"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01750C_A"/>
    <dbReference type="eggNOG" id="ENOG502SZXJ">
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    <dbReference type="InParanoid" id="Q5ALU0"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="165" mass="18606" checksum="3DD5A4EC9D0214BF" modified="2005-04-26" version="1">MSDFAFNNYCIHCDKLCLNNSVYCSEECKSIAYESSLNQLQHNHSTTSANASAAGSTSSVNSTKSNTPSLVSPLLTPALYIQLQQQQQQQHLQINTPLNISSLTPNTNYNNNEYDYDDNDDDELNYFDLNYSVQSNINYTTNTTKSNNELINSTSDNYRKWLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AN96</accession>
    <name>Q5AN96_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C305280CA</name>
        <name evidence="11" type="ordered locus">orf19.13428</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723215.1">
        <property type="nucleotide sequence ID" value="XM_718122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AN96"/>
    <dbReference type="SMR" id="Q5AN96"/>
    <dbReference type="STRING" id="237561.Q5AN96"/>
    <dbReference type="GeneID" id="3635202"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305280CA"/>
    <dbReference type="CGD" id="CAL0000179740">
        <property type="gene designation" value="orf19.13428"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05280C_A"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017661_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AN96"/>
    <dbReference type="OMA" id="WNQGLAY"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000179740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="353" mass="40672" checksum="8379AF785DD18C59" modified="2005-04-26" version="1">MLAKFKLPNAEVWKTFPPFDTPVPPSPFENEFLNKIYYASMNVTTPLTIAIIYFTSVHFINSIIRNKQIAKYNSKTSSESKVDITKLDDKKLQKILPTVPNSIAKTSIFKLFVFLHNVFLCLYSIWTFLGMSHTIATTMNLFEGNFLQSLVNYQPKKLDIFLHSVCDPKIGIFSRLLTNEKGLHNLEVFGWWFYISKFYEVLDTAIILLKGRPSSLLQSYHHAGAMMCMWAGIRYQSPPIWIFVVFNSFIHSLMYFYFSLSCLKIRVPNFFKRILTTMQITQFIVGGSIAILHSFVWIVDTSHVISPDNLKWVSCISTPDQALPILINVLYLLPLTALFTAFYIESYLKKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANC6</accession>
    <name>Q5ANC6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">CEM1</name>
        <name evidence="14" type="ordered locus">CAALFM_C305070WA</name>
        <name evidence="13" type="ordered locus">orf19.13398</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723188.1">
        <property type="nucleotide sequence ID" value="XM_718095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANC6"/>
    <dbReference type="SMR" id="Q5ANC6"/>
    <dbReference type="FunCoup" id="Q5ANC6">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ANC6"/>
    <dbReference type="GeneID" id="3635242"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305070WA"/>
    <dbReference type="CGD" id="CAL0000200784">
        <property type="gene designation" value="CEM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05070W_A"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="InParanoid" id="Q5ANC6"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000009">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000200784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW28522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="441" mass="47082" checksum="EB5061F8FEBA5CD9" modified="2005-04-26" version="1">MTRVVVTGMGMVSPLGVGLSRNWKQLIANKSGLISTTTLPDYESAGWDKIPSKVIGKVPHGTISEGHWQVGDHIPASEARRMATFSHYALASTHEALQDARLLTEDNNALNMDTNKVGVAVGSGIGSFEDIYNNSIAYNASGYKKVQPLFIPKLLNNMAAGNISIKYQTKGPLHSVSTACATGLQAIGDGFNFLKMGYGQVMICGGTESSIHPLALAGFARARSVVTDSEFNSNPTKASRPFDKSRNGFVLSEGCGILVLETLSHALERGVTPDQIYGEILGYGVSGDAYHITAPHEDGTGAYNAMNQAIERSGIDPEQIDYVNAHATSTVIGDRAENNAMMRLFNPQKTKVSSTKSSIGHLLGAAGAVESIFTLNAIKTGQIPATLNLDNVGQHEGDEQSQFKFDYVANKSITMDVNYAVCNSFGFGGVNSSLCFAKYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5APB9</accession>
    <name>Q5APB9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C109810WA</name>
        <name evidence="4" type="ordered locus">orf19.12309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723532.1">
        <property type="nucleotide sequence ID" value="XM_718439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5APB9"/>
    <dbReference type="SMR" id="Q5APB9"/>
    <dbReference type="FunCoup" id="Q5APB9">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5APB9"/>
    <dbReference type="GeneID" id="3634845"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109810WA"/>
    <dbReference type="CGD" id="CAL0000179660">
        <property type="gene designation" value="orf19.12309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09810W_A"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_1"/>
    <dbReference type="InParanoid" id="Q5APB9"/>
    <dbReference type="OMA" id="WILGNLM"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000030">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000179660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW26613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="413" mass="45384" checksum="B512862429F8A225" modified="2005-04-26" version="1">MGREIVIGLVGKPSSGKSTTLNALTDANAKCGAFPFTTIDPNKATGYLEIDCACARFNKQDKCKPNYGYCRNGKRGVPIMLLDVAGLVPNAHLGRGLGNKFLSDLTEADCLIHIVDASGTTDAEGKATRGYDPLQDIEWLQDEIFQWILGNLKERWGSVVRRHIGTKSSTLETMRQQLGGYVANKKLIGDALDLIPDLPPLQDWDDEMLGKVVRAFMEVKFPTVLSLNKMDHPDADKNVSKIILKYPKSKAVLTSSITEVFLRKLAAQNYIKYDSGTEFIDTIDDLPDDPDLKPLDDKLRNRIENIRDLVLYRFGSTGVVQLLQAAADLLNLVPVYPVRNIHNFSGNSGDYVFRDCLLVKKGTSVTAVARKIMGDVTIAAVEGVGGIKISEDDTIDKGKNDILSFKIVPGSHN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2025-02-05" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q9P8W0</accession>
    <accession>A0A1D8PR71</accession>
    <accession>Q3MP71</accession>
    <accession>Q5A5A1</accession>
    <name>LIP5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase 5</fullName>
            <ecNumber evidence="5">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP5</name>
        <name type="ordered locus">CAALFM_C702830CA</name>
        <name type="ORF">CaJ7.0322</name>
        <name type="ORF">CaO19.12646</name>
        <name type="ORF">CaO19.5179</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Arch. Microbiol." volume="174" first="362" last="374">
            <title>Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members.</title>
            <authorList>
                <person name="Hube B."/>
                <person name="Stehr F."/>
                <person name="Bossenz M."/>
                <person name="Mazur A."/>
                <person name="Kretschmar M."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="11131027"/>
            <dbReference type="DOI" id="10.1007/s002030000218"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="FEMS Yeast Res." volume="4" first="401" last="408">
            <title>Expression analysis of the Candida albicans lipase gene family during experimental infections and in patient samples.</title>
            <authorList>
                <person name="Stehr F."/>
                <person name="Felk A."/>
                <person name="Gacser A."/>
                <person name="Kretschmar M."/>
                <person name="Maehnss B."/>
                <person name="Neuber K."/>
                <person name="Hube B."/>
                <person name="Schaefer W."/>
            </authorList>
            <dbReference type="PubMed" id="14734020"/>
            <dbReference type="DOI" id="10.1016/s1567-1356(03)00205-8"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="FEMS Microbiol. Lett." volume="244" first="359" last="365">
            <title>Differential Candida albicans lipase gene expression during alimentary tract colonization and infection.</title>
            <authorList>
                <person name="Schofield D.A."/>
                <person name="Westwater C."/>
                <person name="Warner T."/>
                <person name="Balish E."/>
            </authorList>
            <dbReference type="PubMed" id="15766791"/>
            <dbReference type="DOI" id="10.1016/j.femsle.2005.02.015"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="Int. J. Mol. Sci." volume="12" first="3950" last="3965">
            <title>A novel cold-active lipase from Candida albicans: cloning, expression and characterization of the recombinant enzyme.</title>
            <authorList>
                <person name="Lan D.M."/>
                <person name="Yang N."/>
                <person name="Wang W.K."/>
                <person name="Shen Y.F."/>
                <person name="Yang B."/>
                <person name="Wang Y.H."/>
            </authorList>
            <dbReference type="PubMed" id="21747717"/>
            <dbReference type="DOI" id="10.3390/ijms12063950"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5 8">Secreted lipase that is able to hydrolyze both the neutral triacylglycerols and the monopalmitate ester Tween 40, allowing the use of hydrolyzed products as carbon sources (PubMed:11131027, PubMed:21747717). Exhibits a preference for the short and medium chain length p-NP (C4 and C8 acyl group) esters rather than the long chain length p-NP esters (C12, C16 and C18 acyl group) (PubMed:21747717). Has broad lipolytic activity, which may be important for colonization and subsequent infection, therefore contributing to the persistence and virulence in human tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Fe(2)+, Fe(3+), Hg(2+) as well as ethylenediaminetetraacetic acid (EDTA) and phenylmethanesulfonyl fluoride (PMSF) strongly inhibit the lipase activity (PubMed:21747717). Surfactants such as Tween 20, Tween 80 and TritonX-100 show also inhibitory effect in the lipase activity (PubMed:21747717). Sodium dodecyl sulfate (SDS) sharply decreases the lipase activity by 85% (PubMed:21747717). Methanol, ethanol, and acetone have also negative effect on the lipase activity, with residual activities at 48%, 24% and 44% respectively (PubMed:21747717). Finally, lipase activity is almost lost in the presence of isopropanol alcohol (PubMed:21747717).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="5">0.41 mM for p-NP-butyrate</KM>
            <KM evidence="5">0.27 mM for p-NP-caprylate</KM>
            <KM evidence="5">0.5 mM for p-NP-laurate</KM>
            <KM evidence="5">0.36 mM for p-NP-palmitate</KM>
            <Vmax evidence="5">1.2 mmol/min/mg enzyme towards p-NP-butyrate</Vmax>
            <Vmax evidence="5">1.22 mmol/min/mg enzyme towards p-NP-caprylate</Vmax>
            <Vmax evidence="5">0.2 mmol/min/mg enzyme towards p-NP-laurate</Vmax>
            <Vmax evidence="5">0.7 mmol/min/mg enzyme towards p-NP-palmitate</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="5">Optimum pH is 5.0-6.0.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="5">Optimum temperature is 15-25 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4 5">Cold-activated (PubMed:21747717). Expression is induced in medium containing Tween 40 as the sole source of carbon (PubMed:11131027). Expression is up-regulated during the yeast-to-hyphal transition (PubMed:11131027). Expressed during experimental infection of mice (PubMed:11131027). Expressed in host cecum and infected mucosal tissues (stomach, hard palate, esophagus and tongue) (PubMed:15766791). Expressed at all stages of mucosal and systemic infection (PubMed:15766791).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="AF191318">
        <property type="protein sequence ID" value="AAF69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP006852">
        <property type="protein sequence ID" value="BAE44789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717001.1">
        <property type="nucleotide sequence ID" value="XM_711908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9P8W0"/>
    <dbReference type="SMR" id="Q9P8W0"/>
    <dbReference type="STRING" id="237561.Q9P8W0"/>
    <dbReference type="ESTHER" id="canal-LIP5">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q9P8W0">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C7_02830C_A-T">
        <property type="protein sequence ID" value="C7_02830C_A-T-p1"/>
        <property type="gene ID" value="C7_02830C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641356"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702830CA"/>
    <dbReference type="CGD" id="CAL0000176626">
        <property type="gene designation" value="LIP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02830C_A"/>
    <dbReference type="eggNOG" id="ENOG502SI7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="InParanoid" id="Q9P8W0"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000017824" description="Lipase 5">
        <location>
            <begin position="15"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="110"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="359"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAF69522." evidence="7" ref="1">
        <original>D</original>
        <variation>E</variation>
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15766791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21747717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="11131027"/>
        </source>
    </evidence>
    <sequence length="463" mass="49963" checksum="B1772055F5E7CD65" modified="2011-10-19" version="2" precursor="true">MLYLILFLIAPIYAGLIFPTKPSSDPFYNPPKGFENAAVGDILQSRATPKSITGGFTPLKIQNSWQLLVRSEDSFGNPNVIVTTVIEPVNADPSKIASYQVFEDAAKADCAPSYALQFGSDLTTFVTQAEMYLMAPLLDQGYYVVSPDYEGPKSTFTIGKQSGQAVLNSIRAALKSGKITNIKDDAKVVMWGYSGGSLASGWAAALQPSYAPELGGNLLGAALGGFVTNITATAQATDGTVFAGIVANALGGVANEYPEFKSILQSDTDKKSVFDEFDGHCLIDGVLNYIGTSFLTGDHKIFKTGWDILKNPKIGKVVEDNGLVYQKQLVPKIPVFIYHGSIDQIVPIVDTKKTYQNWCDAGISSLEFAEDASNGHLTEAIMGAPAALTWIIDRFDGKQTVSGCQHIQRFSNLEYPNIPSSIANYFKAAMDVVLHLGLGPDVQKDQVSPEGIKKLGSIEMRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PC84</accession>
    <name>A0A1D8PC84_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">CIS2</name>
        <name evidence="11" type="ordered locus">CAALFM_C100550WA</name>
        <name evidence="10" type="ordered locus">orf19.13474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719015.2">
        <property type="nucleotide sequence ID" value="XM_713922.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PC84"/>
    <dbReference type="SMR" id="A0A1D8PC84"/>
    <dbReference type="FunCoup" id="A0A1D8PC84">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PC84"/>
    <dbReference type="GeneID" id="3639366"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100550WA"/>
    <dbReference type="CGD" id="CAL0000184736">
        <property type="gene designation" value="CIS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00550W_A"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PC84"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="459"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="511"/>
            <end position="512"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000184736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW25753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="636" mass="70261" checksum="8EB40B3330BC0B87" modified="2017-01-18" version="1">MKSEIPPIKNTNYNCKIPRSTFFVVCVFSLLIYSLSTIYRSSGLVLPPLSFIDQIPENLSRSDPYLTLHVDISDDPLSDKIGQPELNPSPKHLHVGSKAMVASDVPLCSTMGKEILLRGGNAADAAVTVALCIGSVNSHSSGIGGGGFIVSRNNGDAISIDAREMAPGSAYKEMYGNSLVLSKIGGLSIAIPGELKGLYELFKLHGSGNLSWKQLFEPVIKLNRNGFKCSKIFETVLAKEYDLVLSRVPVLKDSWDFIFKPNGELLQEGDVITRPNYANTLELIANNGSSSIFYDPNGPIVQSLVSTIQKWGGIATVQDFSNYEVNLEKPLISTINNYTFYTSNGISSGLGLLAGLNFFDRVFNESDDDTLFTHKLVESFKWLSSIRTRFGDIDNRQDLIDKYTNSTWIDDVLDEKKYSDEKTFHWKHYDPKYDIAEPQGTSHFSVVDENDNSVAMTTTVNLLFGSMIYDSKTGIILNDEMDDFALPNVSNAFNLTPSIFNFIHPGKRPLSSTAPTIIINDATNSTDFVIGAAGGSRITSAILQAIVRTYYRKYDLLSTIAFPRLHHQLIPESVMSENLTVWDQEHTGIASSMKKLGHTFLETGSLTAMNGIKRVKGGKLHGVSDWWRKRGESDGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCF5</accession>
    <name>ZCF17_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc cluster transcription factor ZCF17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ZCF17</name>
        <name type="ordered locus">CAALFM_C101170CA</name>
        <name type="ordered locus">orf19.10815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Comp. Funct. Genomics" volume="6" first="345" last="356">
            <title>In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.</title>
            <authorList>
                <person name="Maicas S."/>
                <person name="Moreno I."/>
                <person name="Nieto A."/>
                <person name="Gomez M."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="18629206"/>
            <dbReference type="DOI" id="10.1002/cfg.492"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probably acts as a transcritpion regulator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718128.2">
        <property type="nucleotide sequence ID" value="XM_713035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCF5"/>
    <dbReference type="SMR" id="A0A1D8PCF5"/>
    <dbReference type="STRING" id="237561.A0A1D8PCF5"/>
    <dbReference type="EnsemblFungi" id="C1_01170C_A-T">
        <property type="protein sequence ID" value="C1_01170C_A-T-p1"/>
        <property type="gene ID" value="C1_01170C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640205"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101170CA"/>
    <dbReference type="CGD" id="CAL0000198600">
        <property type="gene designation" value="ZCF17"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01170C_A"/>
    <dbReference type="eggNOG" id="ENOG502SAYY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCF5"/>
    <dbReference type="OMA" id="FPACKYL"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
        <property type="term" value="P:growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070784">
        <property type="term" value="P:regulation of growth of unicellular organism as a thread of attached cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463346" description="Zinc cluster transcription factor ZCF17">
        <location>
            <begin position="1"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1 2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="18629206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000198600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW25812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="738" mass="86034" checksum="553090EAEABE4FE5" modified="2017-01-18" version="1">MTKTTVQRRRHTNSKLGCLNCKRKKVRCDESLPECKNCVKGKKETCSYLSLSTQEIQKIKLTHSLRNSQNKLLDQKYRLPASGAATTSSKRSSSSSSNETRIGKDADAFPSGDILDFKFELKNLPINIPSIVYPPLQFDNIFINDFNGDGVVHNDVNKTSEDDEEDQEVYEEVSGNGRNHSSLTGLNKLDNGVYAPVTFNCLDRRIFRRVLPENVKTKVAADFSFHVVLGKNNLLDHLSDMMLDTPTTAHRNVFSESFLCLGETIILKVFNKRQKILGTYSRSELNFISWLNKKCLDRHGFCQEEIKKLIASFHKNLGKITSWELEKQIHLGAYVSYLLNFVVLMLKFGAQAYFDSSKGIFQSFEAFLAYVEKYTISPSTTVDFLMNNIQYNIMSINVPSYPPQFLFEIESNLRSLEFVFIRPTVFKDESINERFQKIEYHFKSLLKFFSGYVLPIVYASRDENSVSIYPPQAIYEIFQEWHTNVPSETMSHHQSIDANNPSESEFLNDLSTTLYMYYYAVAAALDAVFPGCKYLYGVSFMLPTNKFYRNMKIMTISKDNYYLERLYPFKVDILLQRHVFYASRLFAFFRRRFCFYHNYTDWSSPFDDRLKKNRFKSRTIRNSFEVPIHSFNNTLIRPEHYPLRDEKVALESIEGYPIFTREDETVKQQIYTRNIETLDFFNLSQILQYDCESMLLLRDYRPFDDQIGLTRSTLSMDVIKDYYNDKTVILDSLFSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PD83</accession>
    <name>A0A1D8PD83_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">CDC3</name>
        <name evidence="8" type="ordered locus">CAALFM_C104210CA</name>
        <name evidence="7" type="ordered locus">orf19.8657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330636.1">
        <property type="nucleotide sequence ID" value="XM_019475091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PD83"/>
    <dbReference type="SMR" id="A0A1D8PD83"/>
    <dbReference type="FunCoup" id="A0A1D8PD83">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PD83"/>
    <dbReference type="GeneID" id="3644719"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104210CA"/>
    <dbReference type="CGD" id="CAL0000192358">
        <property type="gene designation" value="CDC3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04210C_A"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PD83"/>
    <dbReference type="OMA" id="RSNPMGS"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="44"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000192358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="428" mass="49060" checksum="111F24561E4642C7" modified="2017-01-18" version="1">MAAVDHSTTGEIVPQNIKIIKKVLNGYVGFANLPKQWHRKSIRRGFSLNIMAIGESGLGKATLINTLFNRDIITSQHDSDEFDEGEEEDVSVKIKSTQAEIEEDGVKLKVSVITAPGFGESINNVEAWKPIVDEINSRFDSYLEAESRINRTAVVDNRVHAFLYFIEPTGHSLRALDIALMKQVHEKVNLIPVIAKSDTLTDEEILEFKHRILADISHQGIKIFKPTDFEYDEEESANTRSIIDSFPFAVVGSTNEVQTPDGRLVRGRKYPWGVIEVDNENHNDFVKLRQLLVRNFLEELKEHTANVLYENYRTEKLKRMGIEQDNTVFREFDPAAKQEEERALHEAKLAKMEAEMKSVFQQKVSEKEKKLQRSEADLFARHKEMKDKLTKQIKLLEEKKAQLEKQKLLPQDPPAQPAPQKSRKGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDC4</accession>
    <name>A0A1D8PDC4_CANAL</name>
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        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
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        <name evidence="16 17" type="primary">ATP1</name>
        <name evidence="17" type="ordered locus">CAALFM_C104610WA</name>
        <name evidence="16" type="ordered locus">orf19.14144</name>
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    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW26135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330645.1">
        <property type="nucleotide sequence ID" value="XM_019475100.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PDC4"/>
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        <property type="interactions" value="1089"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDC4"/>
    <dbReference type="GeneID" id="3646134"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104610WA"/>
    <dbReference type="CGD" id="CAL0000188156">
        <property type="gene designation" value="ATP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04610W_A"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDC4"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="C:hyphal cell wall"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:ATP biosynthetic process"/>
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    </dbReference>
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        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP_synth_F1_asu"/>
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        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="187"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="417"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="546" mass="58985" checksum="C6E55F1E4CADE98D" modified="2017-01-18" version="1">MLSARPVLRTAARTATIAARSSLRVARPTLLTAQRFASAKAAPTEVSSILEDRIRGVSEEANLNETGRVLSVGDGIARIYGLNNIQAEELVEFSSGAKGMALNLEADQVGVVLFGSDRLVKEGETVKRTGQIVSVPIGPELLGRVVDGLGNPIDGKGPIKAAAYSRAQVKAPGILPRRSVHEPMQTGLKSVDALVPIGRGQRELIIGDRQTGKTAVALDAILNQKRWNNGSDEKKKLYCVYVAVGQKRSTVAQLVQTLEQHDALKYSVIVAATASEAAPLQYIAPFTACAIGEWFRDNGRHALIVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKMSDAYGGGSLTALPVIETQGGDVSAYIPTNVISITDGQIFLEAELFYKGIRPAINVGLSVSRVGSAAQVKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTKQTLNRGERLTQLLKQKQYNPLAAEEQVPLIFAGVNGFLDNVALDRIGEFEEAFLGHLKSNETGILDAIKTKGELSKDELEKLRKVTEEFVASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDF5</accession>
    <name>A0A1D8PDF5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAQR-type receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C105010CA</name>
        <name evidence="8" type="ordered locus">orf19.7716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </location>
    </feature>
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        </location>
        <ligand>
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        <ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="324" mass="37945" checksum="F57D23EEEF295BA7" modified="2017-01-18" version="1">MQDSYTLLRQRQKVDNSQTSTELESTPLSKRLHYYHELDEWQQDNHFIKSGYVKQTNSYKECFKSLTYLHNESVNIYSHLLPSSISFWVILYYINYILPKYDNYLGVWEKLNFLQFGLACTFCMFMSSTFHCIKAHSHPVSKFGNQLDYFGIVILITCSLISIILFAYYDYPWYRNIFVGLSLFFGTVCTVLTLDRKFSTNEYRPFRSFMFILFGLSGALPIVNSMYMFGFEITRQKAGVEWLILEGVFYIGGAVLYAARVPERFTHVEDDEHTLLNNPSSGTFDIFGHSHQIFHVMVVIAAFCHWKGLVQSYHYLHLQTLPNL</sequence>
</entry>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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            <end position="102"/>
        </location>
    </feature>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000196976"/>
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    </evidence>
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            <dbReference type="EMBL" id="AOW26284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="452" mass="52941" checksum="700E713DED280C27" modified="2017-01-18" version="1">MFLRYFSVAKIITKNDGGVFNKLVTLVNQQRSFAFKPTAVLFKSKKKKNKQSQIDQLTNALTKTTTQLATQIETIQHNQQEKQSQQQELNDNPKVESSPQTSLDPLIDLPFVPSSLNYSLNNSNLASIKRLIKLSKPDSTIDDGSNNWTFFETGLFWFKDELHQFDKELNFDTITNTDGLTSYITDKILELEIQIGEQLEKKSKENDNYVVNENYFINLIKLIRYKELFTILEKLKDNESLSLLKQFKNIIKLSKYQYYRYLSINEFLSNNGKTGYSNSDDLSMDEFYYYLISTNTINITQTDNYYKICPKLYQISQSSIFPSNIIAKQLLEMITELKLRYGKDETIMPWQKVNKQEISLLPLPIYHITNDSINNYIFSFLVSVEFDNFEILMDDACFGDIYKFKQAFGSTLVEPSKKTMLYIILQDQKRIRELFNDPRIFESYRELLSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE86</accession>
    <name>A0A1D8PE86_CANAL</name>
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        <submittedName>
            <fullName evidence="9">Anaphase promoting complex subunit</fullName>
        </submittedName>
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        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717594.2">
        <property type="nucleotide sequence ID" value="XM_712501.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PE86"/>
    <dbReference type="SMR" id="A0A1D8PE86"/>
    <dbReference type="STRING" id="237561.A0A1D8PE86"/>
    <dbReference type="GeneID" id="3640739"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107850CA"/>
    <dbReference type="CGD" id="CAL0000181158">
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    <dbReference type="VEuPathDB" id="FungiDB:C1_07850C_A"/>
    <dbReference type="eggNOG" id="KOG3437">
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.120.260:FF:000292">
        <property type="entry name" value="Anaphase promoting complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APC10/Doc1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="161"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000181158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW26426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="479" mass="53868" checksum="DE911BD0F9A208FD" modified="2017-01-18" version="1">MNTSGYWDQSSNNNTSFSQHEVRSQRELSQEEIRESLLLSSSITDSSFHHHHHHNHPHNHNHLIHAIDEESSNYSGSQNHVGNNLFGVGDDEEDEEEDDDDAYIEGDVRMRHSGISLDEVVYEENENDADNIIEDQSNQSANPSYNSNNNNNNNAEQTQPSLEQIQRVYYSKGLQELEELQLFDLSPLATWKLSSWKQGFGLKQLRDDSPDSYWQSDGSNTGNSGNDDNNSNQSQNPNNSMLLNQLSNPHSITIQFSKKVALERISIFTNYSLDESYTPSRIKIMAGSSEGWDLIEVCTVNFDQPVGWSHIIFNGIRADGVLKCFLIKIIILANHQEGKDSHIRAIRCFGKKSSTSNQIRYANVANDNDYNIHDSNDSLHHSEMLRDLSLATTGTSAAGMSNLSGFSLNNRIISGLSNKEEEELQHEDQGLIDRNLEEGNTSNDINSEESSKIIKNVTNVIGFNTGFQSLELKSISSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEA0</accession>
    <name>A0A1D8PEA0_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">TERT</name>
        <name evidence="16" type="ordered locus">CAALFM_C108130CA</name>
        <name evidence="15" type="ordered locus">orf19.12555</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="4">
        <citation type="journal article" date="2021" name="Nucleic Acids Res." volume="49" first="4768" last="4781">
            <title>Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi.</title>
            <authorList>
                <person name="Zhai L.T."/>
                <person name="Rety S."/>
                <person name="Chen W.F."/>
                <person name="Song Z.Y."/>
                <person name="Auguin D."/>
                <person name="Sun B."/>
                <person name="Dou S.X."/>
                <person name="Xi X.G."/>
            </authorList>
            <dbReference type="PubMed" id="33856462"/>
            <dbReference type="DOI" id="10.1093/nar/gkab261"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.98 ANGSTROMS) OF 177-867</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717626.2">
        <property type="nucleotide sequence ID" value="XM_712533.2"/>
    </dbReference>
    <dbReference type="PDB" id="6ZDQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.98 A"/>
        <property type="chains" value="A=177-867"/>
    </dbReference>
    <dbReference type="PDB" id="6ZDU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.45 A"/>
        <property type="chains" value="A/B=95-867"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEA0"/>
    <dbReference type="SMR" id="A0A1D8PEA0"/>
    <dbReference type="FunCoup" id="A0A1D8PEA0">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEA0"/>
    <dbReference type="GeneID" id="3640729"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108130CA"/>
    <dbReference type="CGD" id="CAL0000184329">
        <property type="gene designation" value="TERT"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08130C_A"/>
    <dbReference type="eggNOG" id="KOG1005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEA0"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18 19" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="388"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000184329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6ZDQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="6ZDU"/>
        </source>
    </evidence>
    <sequence length="867" mass="100895" checksum="3273E381D5E65062" modified="2017-01-18" version="1">MTVKVNEKKTLLQYVLDNTSNEVPLLPSLKEYMETVLVYQSIKRPLPAIRPQESFDEFMKELVTRLVMEKSNNVIAYGYKTSAMESRSIFTTFHSSGNFILTHITSHNWSTIFSLLGPKKFLELLVNNKGFVSKVNGESVQIFGDVNSHRKAVVVSKYITKFNVLYNSYSRDFSRFEMIRPSIQTILQDILSFSGLNPGRSSKRYRGFKSLLSRIIANDKKCRYDILYAKFIGTSKCNFANVVSNKTEISQVIQFVLLVLGKLLPLDAWGGVSNKKIIKDRVVDFLLLGANEKIHMDDLFRGIRLKDFKWLGRAHQISSKQDFELRTAFLKGYLWWLFEHLLKNILRSFWYITETSSIVSLELNYFPQYLWKELYESWVSKYAKNNLVKMPSKIQREQLPCGKIKLIPKRSSFRVICVPIKRSLKLLNKKLELDTLEKEKREFERYRKEVLSPVGQILRLKLSKLRDTYESYRASVHSSSDVAEKISDYRDSLLTRFGEIPKLFILKFDMKECYDRLSQPVLMKKLEELFENQDNKTSYYVRYYAQLDASHKLKKVKTTIDTQYHNLNILSSSRHLSNCKSLVDKTKTIALQKGNILEVCRSQIYDVVGSVKDARGNLHLYKRKRGVFQGFSLSSIFCDILYSAMVHDCFQFLWKSKQDFLFVRLVDDFLLVTPDSNIYDQVHNILSGKILESYGAFVNKDKTVVVNQTTTKPSIDFVGLEVNTTDLSIKRNSGSISLVTTNFRTFKTLVKYLKTFYQLNLEGFLLDCSFGVLENVLENMGSLLRLVLREFKTKFTSIVKYDTFHCYKFIKFLYDISNYTIVKYVETNSDWDGAPELLNCIKQIIVKEFSSFESYSEIVEWVQTLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEB6</accession>
    <name>A0A1D8PEB6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromatin structure-remodeling complex subunit SFH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SFH1</name>
        <name evidence="7" type="ordered locus">CAALFM_C108160WA</name>
        <name evidence="6" type="ordered locus">orf19.12559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </evidence>
    <sequence length="1166" mass="135108" checksum="76433664B3B0CEEC" modified="2017-01-18" version="1">MLVRRVIVKHTIKPKCHNLVPAFHVASGVISYGNCHGPPKLFQRLDSQLYIRTLSTSSNDNFEIDFVTMKKKPKKLSESDKQQYVSIHKSELPKVDFDNIHFKHRALDEWLFQLFKENQFSASEDRLSNNRLKENLGIIHEIYSELREFEIFVQFKCNKKHFKFSELSTSDILKYLEEFKEVHNGSSQSYHKMYDELSRLLKSDSEFSQTLSYELIPAIQLFEKLFTYYYSGLFVFEQELRTLDKQYDFKKFRSTKDLTHQIEKTLTNFDYSLLHDVDANHTFFKMFIQCSRYSELNKILKTISNINLRDIKNILKDPQYNDYFEAAVQNCIKMEDKDFEMVDQWNEGGGLYYFLTSMKMIPATHDYYKLAPLLFALSKDKGIFASAAGELLRILTNEEVRGPINVASMVDDKQKFPIYAITKNNFTNYVFSFLKSIDFPWESARDTENWDTENLGIENNVFGKGTMYDYLTTNQYFIRRIFSDPNITIKYMELRAKPSFFCLPKDHEILKDVAELKKLRESLQTSFASFKTIDRLLESISKLGTSGTDKNLILSHLLDASRYFGNNTFVLDDVIDEEVKNGQPVAKHDSYSQMPDWLHLESHVPEINFLKSKVGNFSDKNAVMTVIENLTNEIIAEENAHPEINANSFLKLRSKLIEFSINNVNDCLEVLDTVVVNQDAFEKFEQKLGDKKIPAVYIQIPDDFPLHEFVEELSELREVLGKPFSETNVDEILNQVQKFLEKQDLIAIDKTVIWRKLYRNLAMLFKHNNNNTFVLDNVISSAQEFKKFETNHVKNDQNQTAIGSQGQLLVGTAYEVLGEFLRDSGILYKPDVHNISASEFDKLIDQYADKLDKSSSTYLFRKNILDQLKQWNSQIEFYPPFLVCIYGTNYTDELPFASTQLEMFYDDLVKSLKDVAEEQKAAEAENIVAPVDTKLAIDQFKKDVKDKVKYNDSGKLFADLDKKNSAADFEAIKLAVHSAFEEPHEHVVITTNEEVAKHKKELNRVSGESPLKTEPHTVDTSKLEKYLQEAKKLEESKKREKEAFEWSKQTKAPSRAYSFVRSILATSGLVLLSLIGIDFYMKETDKSSSKTITDYQNEENNKLSRTSTTTGPFTVSTISGGTPDVPVIFGKEKIKSVFNWDSTENVSVNDDDNKQMSWWQKLFWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEV5</accession>
    <name>A0A1D8PEV5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">SAC1</name>
        <name evidence="4" type="ordered locus">CAALFM_C109990WA</name>
        <name evidence="3" type="ordered locus">orf19.12329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723550.2">
        <property type="nucleotide sequence ID" value="XM_718457.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEV5"/>
    <dbReference type="SMR" id="A0A1D8PEV5"/>
    <dbReference type="FunCoup" id="A0A1D8PEV5">
        <property type="interactions" value="1406"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEV5"/>
    <dbReference type="GeneID" id="3634864"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109990WA"/>
    <dbReference type="CGD" id="CAL0000200575">
        <property type="gene designation" value="SAC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09990W_A"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEV5"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="113"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000200575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="618" mass="71099" checksum="4CD00D7584657FFD" modified="2017-01-18" version="1">MVLTHSTATDGTHIFHNKVSGNYLILTSGGGVEVSQTIPFVYQNLANAKTISCIIGVIRLKFNSYVIIADKHSVTGSILGHDIGFIESFQILPIGINDLAKKNLEELSYLKLLTTHLNNATLYYSIDNKYDVTNSLQRQFNKSNTGGVVPVDDRFWWNKYLTQDLVNNHVGNDFVHPIIYGYFKSHSAVFNGKSLQFALLTRRSTLRAGTRYFRRGIDIDGNVANFNETEQIFISDDNHLFSLLQTRGSVPVYWAEINNLKYKPNLVISSQSSLDATEKHFHQQVFLYGDNYLVNLVNQKGYEKPVKQAYESAVNNLPEKLGQHVNYIYFDFHHECKGMKYHKINLLLDRLISLGYTSNNYFEYDLNANKIIRLQDKIVRTNCMDCLDRTNVVQSTIGRWVLQNQFTETNYLSSNNVTPFEKLNPQFNLFFQNFWADNADAVSCAYSGTGALKTDFTRLGKRTYKGGLNDFLNSVTRYYKNNLTDGSRQDSYDLFLGKYKPFQDSVRSPFIDRRSPYNQLLPYLMGTSFLILLAIIYFPKGSIWNWKNLFIMAFCILFNLKNLSYINSHGYQFVDWPKLINLDFLKKNEIYTNGTTGKIVGIKYEEAENFTVNNKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF32</accession>
    <name>A0A1D8PF32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">CHO1</name>
        <name evidence="23" type="ordered locus">CAALFM_C111240CA</name>
        <name evidence="22" type="ordered locus">orf19.8294</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713810.2">
        <property type="nucleotide sequence ID" value="XM_708717.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PF32"/>
    <dbReference type="FunCoup" id="A0A1D8PF32">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PF32"/>
    <dbReference type="GeneID" id="3644557"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111240CA"/>
    <dbReference type="CGD" id="CAL0000195699">
        <property type="gene designation" value="CHO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11240C_A"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PF32"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="BRENDA" id="2.7.8.8">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070905">
        <property type="term" value="F:serine binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035865">
        <property type="term" value="P:cellular response to potassium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
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        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
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        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDP-alcohol_PTase-I"/>
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    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
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        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
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        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
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        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0000195699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AOW26749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="273" mass="30747" checksum="5F673504CD99A79E" modified="2017-01-18" version="1">MSDSSATGFSKHQESAIVSDSEGDAIDSELHMSANPPLLRRSSSLFSLSSKDDLPKPDSKEYLKFIDDNRHFSMIRNLHMADFITLLNGFSGFYSIISCLRYTLTGQTHYVQRAHFFILLGLFFDFFDGRVARLRNKSSLMGQELDSLADLVSFGVSPATIAFAIGFRTTVDVLFLAFWVLCGLTRLARFNISVNNIPKDKHGKSQYFEGLPIPTNLFWVGFMALLVYKDWIHDNLPFGIVFQDTSFEFHLVTIGFVLQGCAEISKSLKIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PFR4</accession>
    <name>A0A1D8PFR4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">ACT1</name>
        <name evidence="12" type="ordered locus">CAALFM_C113700WA</name>
        <name evidence="11" type="ordered locus">orf19.12474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330727.1">
        <property type="nucleotide sequence ID" value="XM_019475182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PFR4"/>
    <dbReference type="SMR" id="A0A1D8PFR4"/>
    <dbReference type="FunCoup" id="A0A1D8PFR4">
        <property type="interactions" value="1425"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PFR4"/>
    <dbReference type="GeneID" id="3636195"/>
    <dbReference type="KEGG" id="cal:CAALFM_C113700WA"/>
    <dbReference type="CGD" id="CAL0000191211">
        <property type="gene designation" value="ACT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_13700W_A"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PFR4"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001766">
        <property type="term" value="P:membrane raft polarization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000191211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="376" mass="41739" checksum="2C0DFB442300948F" modified="2017-01-18" version="1">MDGEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSLVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHGILRIDLAGRDLTNHLSKILSERGYSFTTSAEREIVRDIKERLCYVALDFEQEMQTSSQSSAIEKSYELPDGQVITIGNERFRAPEALFRPADLGLEAAGIDQTTFNSIMKCDMDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHHKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG39</accession>
    <name>A0A1D8PG39_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C200490WA</name>
        <name evidence="6" type="ordered locus">orf19.9625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719525.2">
        <property type="nucleotide sequence ID" value="XM_714432.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG39"/>
    <dbReference type="SMR" id="A0A1D8PG39"/>
    <dbReference type="FunCoup" id="A0A1D8PG39">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PG39"/>
    <dbReference type="GeneID" id="3638870"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200490WA"/>
    <dbReference type="CGD" id="CAL0000174052">
        <property type="gene designation" value="orf19.9625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00490W_A"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PG39"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="5">
        <location>
            <begin position="257"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000174052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="669" mass="77326" checksum="632F20C3259951AD" modified="2017-01-18" version="1">MISAIYIIYLAEKQESNEFSQIELLVNRRYHQTLPHDEIILQNFHNLMTNLPSSEQVPVLYYDNLSYIYMRCSNGIISLAVSNRNIDVMSAVMFLNQFHLILVHYLCNSKLNIGNKSAPKSLDRDTIIDNITLILELLDECLDYGLLQITDYKLLEEYIKVLPNIPKIDGLTDKYDTSDSDDSSDEDEPKKETKKSKSKTKIGKNKKGSKKEIKSTHNQAIKTDVIENEQTNMINSSILRTYSSAINWRPKGIFYAKNEIFIDIIEDCEFVYDLGTGVIKCNEIYGTCVVKSYLSGMPVCRLGFNERNLSRIEDDQEEESLGIPENQLNLLKEDQNEDDDEEEGEGDQETNGEETEILEHIPEFPASEALTDKKQKHKIPIRNIQFHQCIELSKIYKENIVTFIPPDDKFVLMTYNVEQQKQKKKAPLIMIKPQFRAIKETGKLQIMCTINTNFHRRRHCKNLIIRIPINPHYFDLDANDNDLKYKAELGEVSFKIDSFELIWKIDSIDGKKMVRMMTELALVNTEEVSEQRISDYLSRRATASSVVGTDEQNSTDTAEDTREELDKFYGVNGKTTSSTQKMSLKFKSSVFNDDIKVHFKLPMVTYSGLKLSYLSVEEEQMKYPCFPWVRYLTKSIDHYEPSIALENQKFSGRCCDYRFKLSSNCFVVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-03-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGB8</accession>
    <name>CSA6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body protein CSA6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Chromosomal stability protein 6</fullName>
            <shortName evidence="4">CaCSA6</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CSA6</name>
        <name evidence="7" type="ordered locus">CAALFM_C201420CA</name>
        <name evidence="6" type="ordered locus">orf19.9022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="4256" last="4256">
            <title>A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans.</title>
            <authorList>
                <person name="Jaitly P."/>
                <person name="Legrand M."/>
                <person name="Das A."/>
                <person name="Patel T."/>
                <person name="Chauvel M."/>
                <person name="Maufrais C."/>
                <person name="d'Enfert C."/>
                <person name="Sanyal K."/>
            </authorList>
            <dbReference type="PubMed" id="35869076"/>
            <dbReference type="DOI" id="10.1038/s41467-022-31980-3"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in mitotic spindle pole body organization, possibly at the point of spindle pole body separation (PubMed:35869076). Required for mitotic exit (PubMed:35869076).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Spindle pole body</location>
        </subcellularLocation>
        <text evidence="3">Also localizes to the bud neck and buds.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Leads to an elongated mitotic spindle (PubMed:35869076). Restricts localization of TEM1 to one spindle pole body in a large proportion of cells (PubMed:35869076). Increases the level of CSE4 protein in the cell (PubMed:35869076). Cell cycle arrest at the late anaphase/telophase stage with segregated nuclei and 4N DNA content (PubMed:35869076). Simultaneous disruption of BUB2 partially suppresses the cell cycle arrest phenotype (PubMed:35869076).</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722497.2">
        <property type="nucleotide sequence ID" value="XM_717404.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGB8"/>
    <dbReference type="SMR" id="A0A1D8PGB8"/>
    <dbReference type="EnsemblFungi" id="C2_01420C_A-T">
        <property type="protein sequence ID" value="C2_01420C_A-T-p1"/>
        <property type="gene ID" value="C2_01420C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635841"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201420CA"/>
    <dbReference type="CGD" id="CAL0000194943">
        <property type="gene designation" value="orf19.9022"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01420C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PGB8"/>
    <dbReference type="OMA" id="LSHENNH"/>
    <dbReference type="OrthoDB" id="10267903at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905047">
        <property type="term" value="P:mitotic spindle pole body organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000460031" description="Spindle pole body protein CSA6">
        <location>
            <begin position="1"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Dungan J."/>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
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                <person name="Berriman M."/>
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        </source>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="618"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000187516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="717" mass="81946" checksum="23BD0E63D84D7761" modified="2017-01-18" version="1">MSSSSQRQANSYSRRAPFHDDTNNQSSFRNQPNRNEPPLNRGRGYNEHQGRRSDAMPNRGDPRRPDNCNDGYNDRRDDGRGDKNKRFQHPGRSEEQPKYFGRGNRESSQHQSPQSSRHSGREGQGQGPDRNRNDQRYDPRRNDGRTGNNPPHYKPNRSNDVPIANRGTKRSNQEHDAGPFKQPRLSDEYTQRSQQQQFSSRKPYNNKPDQKNGSNRKSDSKFSQPKFQKSRSSFQNRGRGNDWDRSGEAYTPSSKRSDNPNFSGQRKFEPQSSLARARTISVAKPKSINEILKEIDRLQNRVQDLQSVQPIEEVKVIDSRWNKVPEGFENLSAARAKLSGLFPLPGYPRPIDFTKLEGTIKNRLNNSDDILNETSRIDPVDSKAARTLIVKNDLSQISHLKLVEFFNDYLKAIDFEKGSSNNIKKQKKAQDNKFMIIEFNNAECATIIYSLNETELLFNAYKEEKVPARQMEKFKLLIARPSEYVVQDLEPVKSDEIEEVVRDNSRKISLTIVPNATPSKVIESLEKNVGALQGIQFLRQKGTKNLLGLVFVEFKDSSNDVIGKLRRLPFITRAFHSCILPNKTPIQKGPIDFHSLKNLVENKNVAPHPSSRVIRLLNAVTESELADDATYSFIRNDMYNEASKYGEVVNVRIPRPSRNHTPGILQFNTSTGLGTIYIEFKDEKIALAAMMELAGKSYNDRTVLATFYDFDDFLMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH13</accession>
    <name>A0A1D8PH13_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">GCD7</name>
        <name evidence="11" type="ordered locus">CAALFM_C203990WA</name>
        <name evidence="10" type="ordered locus">orf19.8445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720949.2">
        <property type="nucleotide sequence ID" value="XM_715856.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH13"/>
    <dbReference type="SMR" id="A0A1D8PH13"/>
    <dbReference type="FunCoup" id="A0A1D8PH13">
        <property type="interactions" value="1128"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH13"/>
    <dbReference type="GeneID" id="3637367"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203990WA"/>
    <dbReference type="CGD" id="CAL0000187213">
        <property type="gene designation" value="GCD7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03990W_A"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH13"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000187213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="365" mass="40967" checksum="D0DE88718C5B6816" modified="2017-01-18" version="1">MSKLLTPEILALIDPVVSSLKRHQLVDDKEIALTIAQLLMKVISAARWSNTYDLIELIRQVGVIFTEAYPRKVIPGNIVRRVLALIRDETETETETETEQTDNIPMMSSMFSLLATHNKNETIKEQTQLQSKKQTSDMRAIIIQGIRDLVDEISNVNDGIETMAVDLIHDDEILLTPTPNSETVQHFLIKARLKRKFTVVVTENYPNDIKAAHKFVKTLAEHNIETILIPDTTIYAVMSRVGKVIIGTNAVFANGGCLSDSGVANVVECAKEHRTPVFAVAGLFKLSPLYPFTRNDLIEVGNSGKVLNYDDFELVQNVDVVTNPLEDYIPPQHIDIFMTNIGGFSPSFIYRIVLDNYKAEDNKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH79</accession>
    <name>A0A1D8PH79_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tpo5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">TPO5</name>
        <name evidence="9" type="ordered locus">CAALFM_C204690CA</name>
        <name evidence="8" type="ordered locus">orf19.7792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710602.2">
        <property type="nucleotide sequence ID" value="XM_705510.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH79"/>
    <dbReference type="SMR" id="A0A1D8PH79"/>
    <dbReference type="FunCoup" id="A0A1D8PH79">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PH79"/>
    <dbReference type="GeneID" id="3647791"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204690CA"/>
    <dbReference type="CGD" id="CAL0000190535">
        <property type="gene designation" value="TPO5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04690C_A"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH79"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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                <person name="Chibana H."/>
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            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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</entry>
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                <person name="Dungan J."/>
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        </source>
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    <reference evidence="3 4" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000182539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="335" mass="38546" checksum="618E8FFDBD9475F4" modified="2017-01-18" version="1">MVVQKEIDLNKPLDANAAPVLAKTTLKPELSKAAIVLHGDRYKQLQAKLTKYVLWHPISIVVYTTVLPVVVGYALWDYISISDHLIEFYHIMMKEKKDFIFSFFTAFPLFASVFASFGFLAYIVGEDMGIITSKFYAQKYCDYIFGFDIKSYSQNETGKDKKLTRKSLDTQLIVYRDSPIAICSLVVDETQSSAANFIVKITGIHVRKVFQKVNFDEVLIDWAVVRARELYQEFLTSKNIKTPPENSSILITIDAYSFDNAFEKTLYNHGFRILDSSFELNPFSPAVSWYKERLYRFLNVSRDSFGLMLTIAKDDIESINSDTKQNNQSKIKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI19</accession>
    <name>A0A1D8PI19_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phm7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">PHM7</name>
        <name evidence="14" type="ordered locus">CAALFM_C208140CA</name>
        <name evidence="13" type="ordered locus">orf19.9716</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716011.2">
        <property type="nucleotide sequence ID" value="XM_710918.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI19"/>
    <dbReference type="SMR" id="A0A1D8PI19"/>
    <dbReference type="FunCoup" id="A0A1D8PI19">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI19"/>
    <dbReference type="GeneID" id="3642329"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208140CA"/>
    <dbReference type="CGD" id="CAL0000191215">
        <property type="gene designation" value="PHM7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08140C_A"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI19"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="PHI-base" id="PHI:8121"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="194"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="385"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="829"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000191215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW27808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="927" mass="104369" checksum="95D52A83100F7A50" modified="2017-01-18" version="1">MAGSSIPQSSNSSVSQFLSTLIPTLVVSVVFLLAFIVIHSKQRRVYEPRAVVESLPDDLRTETAPKGPFSWLTYLLAKPRTFYIQYAGTDGYFFLRFLFEFFCVCVLGAVITWPILFPVNATNGNNNTPGSNVKGFDILTFANIKDKWRTFAHVFLSWILFGAVIFLIYRELVYYVTYRHALQTTPLYDSLLSSRTLLLTEISTEYLQDDKLRGYFPTATNIWYSRDYKKLQKQVKERTKLANKYEGTLNKVLTKAVKLRNKCLKKSKPAPEPQDDIDKYLKDGKKRPTHKLKFLIGIKVDTLDYSPEKLGELNKEITKEQTEYQTYDQLPAVFIEFPSQLEMQKAYQAIPYQPDFKGVKTVINAAPEDIIWENLQLTSMKRRIKSIIANTILTLLIIFWCIPVAVVGAISNINVLTDKVPFLKFILKMPDVIMGVITGLLPVVALTILMSLVPPFIKWMGKISGRLTIQQVESYCQSWYFAFQVVNVFLAIALGSSAAAVATQIVQNPGEALQKLSSSFPKSVNFYYSYLCLEGLTISSGVLLQIVALILSHILGRILDGTPRAKWTRWNTLGQPAYSTLYPGFQLLTVIALSYSVIAPLILGFTAIAFILFYFAYIYTMIFVLRPSTVDARGTNYVKSLFQLFTGLFLAQLWITAIFVFSKNWACVALEGVIVVVTIAARLWMKWKFLPLVDAVPISAIKYAAGDPTYSYPIHDQGLKEIKVEGKNYWEGGNQLGLGPDPKDQVLPDRIPGNGPSSYAYDQQQQQNHRGSDSSAVDTKVGHGESLDKPKSPFTDFNNNHDAEKSAGFNPVNKAIAAPTQGVSWLTSFFQPKKDTFDIIKSDMPSSYFNYIEYHSDFIRHAYDDPAVTAEEPHIWIARDPMGLSEIEKNKALKEGVQVSDENATFDDKGALIFTGPPPAYEEPIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI93</accession>
    <name>A0A1D8PI93_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">RPT6</name>
        <name evidence="15" type="ordered locus">CAALFM_C208780WA</name>
        <name evidence="14" type="ordered locus">orf19.11075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714440.2">
        <property type="nucleotide sequence ID" value="XM_709347.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI93"/>
    <dbReference type="SMR" id="A0A1D8PI93"/>
    <dbReference type="FunCoup" id="A0A1D8PI93">
        <property type="interactions" value="1130"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI93"/>
    <dbReference type="GeneID" id="3643877"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208780WA"/>
    <dbReference type="CGD" id="CAL0000174449">
        <property type="gene designation" value="RPT6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08780W_A"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI93"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0000318"/>
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        </source>
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    <sequence length="401" mass="44962" checksum="B46969DF6673A104" modified="2017-01-18" version="1">MTTSIDKPYVHEGGIRPYFEQQIQDTEIRIQQTTQNLRRLEAQRNKLNNKVRQLKDELRLLQEPGSYVGEVVKVMGLKKVLVKIHPEGKFIVNVTKDIDVKKLTPSIRVCLKADSHDLYKILPNKVDPLVSLMMVEKVPDSTYDMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTECKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFESSKDIKIIMATNRLDILDPALLRPGRIDRKIEFPAPTVAARTDILKIHSRSMNLTRGINLRKIAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVAKVMSKNDDGAVSLQKLFK</sequence>
</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_709468.1"/>
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    <dbReference type="SMR" id="A0A1D8PIF0"/>
    <dbReference type="STRING" id="237561.A0A1D8PIF0"/>
    <dbReference type="GeneID" id="3643794"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209650WA"/>
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        <property type="gene designation" value="orf19.8967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09650W_A"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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    </dbReference>
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        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="RRM_euk-type"/>
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        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
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        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
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            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000183410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="163" mass="18534" checksum="41C266DED6A30296" modified="2017-01-18" version="1">MSEEKVRVQETEEERQERLAKQEEIDGRSVYVGNVDYQSTPEQLEEFFHGVGVIERVTILFDRFSGLPKGYAYIEFEQTESVQKAIDELHGKEFRGRELRVTAKRTNLPGFRRGRGRGGFRARGRGRGGFRGRGRGRGGFNSRGTRNGDSEQADGDAENEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PII6</accession>
    <name>A0A1D8PII6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">PMS1</name>
        <name evidence="7" type="ordered locus">CAALFM_C209470CA</name>
        <name evidence="6" type="ordered locus">orf19.9173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
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        <property type="protein sequence ID" value="AOW27927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_705594.2"/>
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        <property type="gene designation" value="PMS1"/>
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    <dbReference type="eggNOG" id="KOG1978">
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="227"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="702"/>
            <end position="850"/>
        </location>
    </feature>
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            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
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            <begin position="399"/>
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        </location>
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            <end position="428"/>
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        </location>
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    </evidence>
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        </source>
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        </source>
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        <source>
            <dbReference type="CGD" id="CAL0000197853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="910" mass="104431" checksum="9A04AE62EAC4336B" modified="2017-01-18" version="1">MSETSPSIKTISKFDISKITSSQVIIDLKAIIKELIENSIDAHADKIDIIFHNYGVNSIQIQDNGNGINVTDFETICLRNHTSKIENFEDLDQLTTLGFRGEALNSICSLSNKLTITTTKEDLYPKCHVLNYDNMGQLVDQRIKVGGLNYKSGTSIMIEQLFKNLPVRLKNFVKNSKKEFSKAINFVINYLIIYPQIKFTIYNVLNNHKKLILATKGGDNTTIIDNLISIYGNNNNKNLLSLDLEITEDIKLVGYISSYSFGLGRSAPDRQFLYLNKRPIVFKKLYKLINEIYKSYNHVQYPIYIIDIVINPNLVDINLLPDKTNVLIKDETTILQTIETKLSEFFEVQDTMIIPKNENYQVKNSEIEIVEKTDNKNIAVHDDIDTSYKTKINATRLEGPSEDKDDLNGNDKQEKTGDQDEQEQENDDEQQRPEVDNDVINLSEPVRKTDKDSDNKKVSEIDNNENVANQISTVNQPSNSQGVLSTNEQNEMSENIKITTFEPILESAEPSTIENKHIILDEPVVLESSQENNNNSIFSSHDIKSSPQNTCTADTLEMNKLFCHQEHDEEEDKCDHQDNHGKNFYPVKHKLDDSEEENMTVISIGDETFQQYDERRPSKRLKRDMLRNMYNKKIVNSSQDILSSINKNLQSPQNQSESIVIKKEPDEVKPNSVEDLQTNQQQQYEEVESYQINKQDFLKMKLIGQFNLGFIIVDFDDNNNLFIIDQHASDEKYNFEKLMASFKINYQLLIKPIKLELSVIDQMLVIDNQEIFHNNGFKLKINSTPVDNEILLLTLPIYQNITFNLDDFNELLNLVSQQQDQVNPNLKCSKIKKILAMKACRSSIMIGTFLSKSKMREIISNLSTLDKPWNCPHGRPTMRHLIDIKNWQPTSSASRTSSNGFPSTSVDYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ78</accession>
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        <submittedName>
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    <gene>
        <name evidence="1" type="ordered locus">CAALFM_C301440CA</name>
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    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PJ78"/>
    <dbReference type="STRING" id="237561.A0A1D8PJ78"/>
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    <dbReference type="InParanoid" id="A0A1D8PJ78"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AOW28186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="101" mass="11433" checksum="5B921A226E8448E5" modified="2017-01-18" version="1" fragment="single">EKDTIATINTNSSLLTKKNITELIPILIELITSATTTKGKSKSNIDIKVLSLKNLKLIIEKFDDIINKQKLLNDLLPALDDKKRVVRKLTIDLRQSLYDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJD7</accession>
    <name>A0A1D8PJD7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">RNA1</name>
        <name evidence="6" type="ordered locus">CAALFM_C301990WA</name>
        <name evidence="5" type="ordered locus">orf19.9218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="3 4" key="2">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <reference evidence="3 4" key="2">
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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            <dbReference type="PubMed" id="24025428"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000201056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="138" mass="15968" checksum="A1A1F3290668A569" modified="2017-01-18" version="1">MEFLVLAIIGATYASVLFEPSAQSVRNMRRVNNRSTYTNVNSFKRKIKRSSKIKLARPKVKNRKNRMQWQPEQTIATSTAFNMTPEQRAAGARPHKTANTVCFNESYSNEEPPPYSAREKGSRRKKLKLKLRSFFKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM37</accession>
    <name>A0A1D8PM37_CANAL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C404400CA</name>
        <name evidence="2" type="ordered locus">orf19.1409.3</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
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            <taxon>Debaryomycetaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330927.1">
        <property type="nucleotide sequence ID" value="XM_019475382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM37"/>
    <dbReference type="SMR" id="A0A1D8PM37"/>
    <dbReference type="GeneID" id="30515268"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404400CA"/>
    <dbReference type="CGD" id="CAL0000200415">
        <property type="gene designation" value="orf19.1409.3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04400C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PM37"/>
    <dbReference type="OMA" id="FKHKLYN"/>
    <dbReference type="OrthoDB" id="4024206at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000200415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="91" mass="10717" checksum="0D08823F1C665595" modified="2017-01-18" version="1">MSILTTITNRLTNYTTNFQNNKLNHQPNIDEGTTVTENAYGLFDLFLYYLMNLILFMVLFIDLIVEFIKNCVHNYNIVACSFKHKLYNNIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM41</accession>
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        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
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            <fullName>60S ribosomal protein L22-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL22B</name>
        <name type="ordered locus">orf19.1409.1</name>
        <name type="ORF">CAALFM_C404390WA</name>
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    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW29188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
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        <property type="resolution" value="2.64 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="5=1-124"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="5/BP=1-124"/>
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        <property type="resolution" value="3.20 A"/>
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        <property type="chains" value="5/BP=1-124"/>
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        <property type="interactions" value="761"/>
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    <dbReference type="EnsemblFungi" id="C4_04390W_A-T">
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        <property type="gene ID" value="C4_04390W_A"/>
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    <dbReference type="GeneID" id="30515267"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404390WA"/>
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        <property type="gene designation" value="orf19.1409.1"/>
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    <dbReference type="InParanoid" id="A0A1D8PM41"/>
    <dbReference type="OMA" id="WIRFIST"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
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        <location>
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            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="124" mass="14089" checksum="92886E261D213AEC" modified="2017-01-18" version="1">MAPVTSKKSKSVKKFVVDVAAPVENDVFDQESYVKYLVEHVKVDGIVGNLGNDISITAESDNKVVVVVSGNGSFSGKYLKYLTKKYLKKNQIRDWIRFVSVKQNQYKLQFYAVAEDDEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM83</accession>
    <name>A0A1D8PM83_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetylornithine aminotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">ARG8</name>
        <name evidence="13" type="ordered locus">CAALFM_C405070CA</name>
        <name evidence="12" type="ordered locus">orf19.11254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717176.2">
        <property type="nucleotide sequence ID" value="XM_712083.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM83"/>
    <dbReference type="SMR" id="A0A1D8PM83"/>
    <dbReference type="FunCoup" id="A0A1D8PM83">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM83"/>
    <dbReference type="GeneID" id="3641131"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405070CA"/>
    <dbReference type="CGD" id="CAL0000177288">
        <property type="gene designation" value="ARG8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05070C_A"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM83"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000177288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW29248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="455" mass="50197" checksum="22AC8B6DE7B08096" modified="2017-01-18" version="1">MLRTYSKSLLKTSTTIKKSFSFNTATLSLPTNKKYSTSVPDANDESHTGKFINSISKPYSVTTYARPNLVLTHGKGSYIYDLEDRKYIDFTSGIAVTCLGHSYEPITQLIKDQSEKLIHCSNLYYNLPAGELSNKLIVKTKEFDGMKDASRVFLCNSGTEANEAALKFARKYGKSINPEKYEFITFENSFHGRSMGALSVTPNPKYQEPFSPLIPGVKIAKPNDIESVKQVINKDKTCAVIIEPLQGEGGVNIIDESFLIELRKLCDENNVLLIYDEIQCGLGRTGKLWAHSWLSPEAHPDIVTIAKALGNGFPIGATMITEKVEKSLNVGDHGTTYGGNPLASTVGSYIVDHIGDKEFLQQVENKSQIFLEGLNKIAEENSNLIEKVKGKGLLLGLQFKENVDIGEIVAKCRQHGLLIITAGMNTIRLVPALNIPDQTIKDGLEILTQSIKEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMP0</accession>
    <name>A0A1D8PMP0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oye32p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">OYE32</name>
        <name evidence="8" type="ordered locus">CAALFM_C406780CA</name>
        <name evidence="7" type="ordered locus">orf19.10643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715440.2">
        <property type="nucleotide sequence ID" value="XM_710347.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMP0"/>
    <dbReference type="SMR" id="A0A1D8PMP0"/>
    <dbReference type="STRING" id="237561.A0A1D8PMP0"/>
    <dbReference type="GeneID" id="3642919"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406780CA"/>
    <dbReference type="CGD" id="CAL0000174577">
        <property type="gene designation" value="OYE32"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06780C_A"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMP0"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000441">
        <property type="entry name" value="NADPH dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000174577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW29399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="432" mass="47517" checksum="81261F39994B432C" modified="2017-01-18" version="1">MTVPYQVKPSDEIKGAPEVSYYTPEQPVPAGTFYPQSSDEVAPKIFQPLKIGKLALPNRIGVSPMCQYSADYNFEATPYHLIHYGSLVNRGPGITIVESTAVSPEGGLSPHDLGIWKDEQAEKLKPIVDYAHSQKQLIAIQLGHGGRKASGQPLFLHLEQVADKSVNGFADKAVAPSALAFRPNGNLPVPNELTKDEIKRVVKDFGAAARRAVEISGFDAVEIHGAHGYLINEFYSPISNKRTDEYGGSFENRTKFLKEVIDSVKSSIPNDVPVFLRISAAENSPDPEAWTIEDSKKLADILVEKGIALVDVSSGGNDYRQPPRSGISKELREPIHVPLSRAIKQHVGDKLLVSCVGGLEKDPELLNKYLEEGTFDLALIGRGFLRNPGLVWEFADKLGVRLHQALQLGWGFWPNKQQIVDLIERTSKLEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMQ1</accession>
    <name>A0A1D8PMQ1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C406860CA</name>
        <name evidence="15" type="ordered locus">orf19.3123.2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330944.1">
        <property type="nucleotide sequence ID" value="XM_019475399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMQ1"/>
    <dbReference type="SMR" id="A0A1D8PMQ1"/>
    <dbReference type="FunCoup" id="A0A1D8PMQ1">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMQ1"/>
    <dbReference type="GeneID" id="30515286"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406860CA"/>
    <dbReference type="CGD" id="CAL0000191434">
        <property type="gene designation" value="orf19.3123.2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06860C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PMQ1"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006216">
        <property type="term" value="P:cytidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006217">
        <property type="term" value="P:deoxycytidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="56"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000191434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW29407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="147" mass="16209" checksum="4C1CD2DCE6B18361" modified="2017-01-18" version="1">MSIPKYTDHKELTDAEFTNLKENVIKAKSAAYCPYSKFRVGCTLLTESGEFISGANVENASYGAGVCAERTAIVKAVTDGHKKYKAIAVAGNTKDPITPCGICRQFIREFAPEIPVYMFNEENRFIKVYLQDLLPLSFGPEDLGVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN34</accession>
    <name>A0A1D8PN34_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial 15S rRNA processing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PPR4</name>
        <name evidence="5" type="ordered locus">CAALFM_C501140CA</name>
        <name evidence="4" type="ordered locus">orf19.9511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="CGD" id="CAL0000194004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="753" mass="86332" checksum="B217CE3A262B2829" modified="2017-01-18" version="1">MIPLRQIVGRTTRSGFLQIRSASKAGTIALRYQSTTSTTTNTATPTTTPDNDNSKPSSETVKTEQSSLPKATQKGKQDKKAPSKKTPVNPKLRDISGQIKETIIQSTTDLNEAYSILEEGITFLREIQKSENITDRQIFKEFYPLATELFNLAQKPETTIDHSLNEIIDMFVKNKIAHSMHFIQLAANALKQNSEAYDEVLQYWFKSFEYTKSHDFLYVNNFNGIKTKIEYQPYDFTNLAIYAYVQSCIAQKVTYSPVDAAKFSPSGKIPPFYHIKKTLEVLDIYDGKKFREYCNLLETDSQERFNPNGASSIKKIENTPDKKQLDKFYQNVVDICNKRNIKVDEKVIVALMQRYFQFDEYNEVFSLFETIMNSGVKPSIDAWNIVIKAMTNPSRIASFGGKAKQQELVQNFERTLQTIVSSGVQFNGETVGAIVSGYANFGQFDKAQEYIDKYAKGVKDNGAVISLCNDGILRGLVYNGKIEEAESKLKQFMETHTQYKPHTHVMNDFLNYYAKKKNYKAINGITNFMRKHNIAENVSIKTTMINAYFESLHAIGKTPDLSSFLAKMESSENAGKRGFNEQMHSTLLKGLIQGANIEAARQLFDILKSRYPRSAWLNTNMMVGELTLGNVKLGEDIFNYYIKEIRNEPIIWNTFIHNLLARDEKLADFYFEKMKQDSQVQPNFYTYYFMLQHYRRKAKKDRLQQLVNELAEVDWTSYGTSLPDFIKRLTNYLDVPASLLSKLDKQQATVDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN68</accession>
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        <recommendedName>
            <fullName evidence="4 7">NEDD8-activating enzyme E1 regulatory subunit</fullName>
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    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C501590WA</name>
        <name evidence="9" type="ordered locus">orf19.13678</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
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    </organism>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; protein neddylation.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG2016">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
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    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000191482"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW29592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="533" mass="60931" checksum="66A5C9C926272926" modified="2017-01-18" version="1">MSIDKSAKYDRQLRLWASTGQSNLENSHICLINATSTGSEILKNLILPGIGQFTIIDEKKVTKQDLSSNFFLKNQDLNEDLAVAIQKNLNELNNDVNGHAIVESLSTILAQESNLFWDQFNVVIVSDYTPNLEPLINLLWSKQIPLFIVNTIGFYGSLNIIANETTVIETHDPSKLYDLRIDHPWPELQEFADSFDLDKLNDVEHAHVPYIVIFIKALDHWRSQHDGQVPITYADKKKFRLYVKSLSRNFELETNFIDADNAHLRPHQKTEIPESIIQLISISETKKLDDSTTSIFWIFIAALKNFLNLNDQLLPLPGTLPDMASDTENYVRLQQIYRDRALKDQKLFTEQVYQILDSLGRSRDEVNQESIASFCKNARLLFATVGSKDLINDKLVNQYNYNPTTAISSGSGGGGSITILDDEEKHKLGIYFGLLTFNLFIDKYHYKPTINDFNKFLKIYHDEISPKFKLNENGEKIFKEILTHNTTNYHNLNSLMGGIVSQEVLKSTTAQYIPLDNLFVFDGIHSKSEKFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNI0</accession>
    <name>A0A1D8PNI0_CANAL</name>
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        <submittedName>
            <fullName evidence="6">SNAP receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">PEP12</name>
        <name evidence="6" type="ordered locus">CAALFM_C502720WA</name>
        <name evidence="5" type="ordered locus">orf19.11768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="9 10" key="3">
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                <person name="Weissman J.S."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714320.2">
        <property type="nucleotide sequence ID" value="XM_709227.2"/>
    </dbReference>
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    <dbReference type="STRING" id="237561.A0A1D8PPI6"/>
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        <property type="gene designation" value="CIP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01070C_A"/>
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    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000174960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW30053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="299" mass="33037" checksum="B659402BDEFCF8D4" modified="2017-01-18" version="1">MSKVSITIIGLNGFLGKPVLEAINSGIFDDKINFPIKAITRKEPETKNDKIEYVVSEINEESIKSTLSQKLSGTDVIIELIGPNPEAFANIEKLIDAIKPKLFIPSQFGTDIPKVDEYAPGFLGIKTQHSENVRKLGVKVVDIITSLFAVPGAFLYEWVGSTGINADDKTVKLIGDINQQFDISKLEDVGKAVLSIATNPNPRELPDTIRIGSDRITVKDVIDRYSKDHNVELKVVSEQSAEDAKKEFTESLKAGFDGEKFLWYLQVIAAQGLDKGLLSSKLDNELVNPGESLWKWGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPM1</accession>
    <name>A0A1D8PPM1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DnaJ-related protein SCJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C601460CA</name>
        <name evidence="11" type="ordered locus">orf19.10942</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716745.2">
        <property type="nucleotide sequence ID" value="XM_711652.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPM1"/>
    <dbReference type="SMR" id="A0A1D8PPM1"/>
    <dbReference type="FunCoup" id="A0A1D8PPM1">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPM1"/>
    <dbReference type="GeneID" id="3641623"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601460CA"/>
    <dbReference type="CGD" id="CAL0000177221">
        <property type="gene designation" value="orf19.10942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01460C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPM1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111217" description="DnaJ-related protein SCJ1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="150"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000177221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43014" checksum="A5D04B7A2CA5006C" modified="2017-01-18" version="1">MKASFIIGILFFYLTSFSIAKKDFYQILGVEKSASNKEIKSVFRQLTLKYHPDKNPNDTEAHDKFLEIGEAYEVLSDPEKRRNYDQFGDPNGQPQPQGGGAHFDFGDMFGQFFGGHGHGHGQQQRQQPGKRKGDSAQLGLNIPLSDFYNGKIVEFDVEMMNDCEYCDGTGSKDKQRKVCDRCQGTGHITVTHQLAPGMVQQMRMACDQCGGIGKVVNDPCNHCHGQGISRGPRHYEIYVKPGQPRDSPHVLEGEGDKNPNWIPGDLIVLLKEELDKSWGYRRIGSHLYRTEALTLNESLYGGWERKIAFLDNEEPQLTLSRDQGIPVFDGEVEIVSGKGMPIVTDHDEEERFGDLFIEYKVIIPGGAPKGKNSNSKKGVTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPY6</accession>
    <name>A0A1D8PPY6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C602690CA</name>
        <name evidence="6" type="ordered locus">orf19.12987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
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</entry>
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    </organism>
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            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718069.2">
        <property type="nucleotide sequence ID" value="XM_712976.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ84"/>
    <dbReference type="SMR" id="A0A1D8PQ84"/>
    <dbReference type="FunCoup" id="A0A1D8PQ84">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ84"/>
    <dbReference type="GeneID" id="3640298"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603630WA"/>
    <dbReference type="CGD" id="CAL0000174002">
        <property type="gene designation" value="PAD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03630W_A"/>
    <dbReference type="eggNOG" id="ENOG502QWR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ84"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="7">
        <location>
            <begin position="42"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000174002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW30292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="229" mass="25812" checksum="EAA1561FCECB9481" modified="2017-01-18" version="1">MIARVCLRRSNVLPIFQIPSRKYSINYEKVNNSIYNNVIKPKRIVLAITGATGTQIGVRLLEILKELGVETHLVMSKWGIATLKYETDYQVDYVTSLATKTYSARDVTAPISSGSFVHDGMIVAPCSMKSLSAIRTGFTEDLIVRAADVSLKERRKLLLVARETPLSDIHLDNMLYLSRMGVTIFLPVPAFYTKPKTIDDIVEQTCGRILDNFGINIDTFERWDGINHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ97</accession>
    <name>A0A1D8PQ97_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PHO80</name>
        <name evidence="3" type="ordered locus">CAALFM_C603810WA</name>
        <name evidence="2" type="ordered locus">orf19.13178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718091.2">
        <property type="nucleotide sequence ID" value="XM_712998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ97"/>
    <dbReference type="SMR" id="A0A1D8PQ97"/>
    <dbReference type="STRING" id="237561.A0A1D8PQ97"/>
    <dbReference type="GeneID" id="3640286"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603810WA"/>
    <dbReference type="CGD" id="CAL0000183853">
        <property type="gene designation" value="PHO80"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03810W_A"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ97"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000183853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="52038" checksum="0CE85D04A08266C7" modified="2017-01-18" version="1">MLVDNYIKASSIKFNISIAPCVEIARYLKSNQQQQVRLQPHEDPKQLLSHQQQQQPDTQYHYQNHHHNKQYRQRQRRQTQEHKQQQGTPRIRRPSSSLSPLYSPKTKKSTPNKTTKTLLHKSSTSPTSPPPPKKKKSKNRIIVPNEFINCDLDIIITLINRMLISLIKLNDNNINNNNNTTNINNPTPPTRFHSKTPPAISIFSYINRLTKFNNLKSSGLITMIYYIDILSYMYPHFQLNSWTIHRFLLVATMISQKAMEDYFYTNDHYAKVGGVSLEELNCLELDFLKRIDWRTIPINNPNVQQLYYNKLVEMTGKISNMVDNNNSSDSDNTDTRYKHTKFIMENEDPTDDEEEEEGDSEDSEEDLEDDDDEDDDDEDDEFYDSDEDINSEDNGDIEIDDYEMEEENNSNVPDLPNIPMYKYDNNGFSMDGSSSPHLKRRYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQH7</accession>
    <name>A0A1D8PQH7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADK2</name>
        <name evidence="11" type="ordered locus">CAALFM_C700060CA</name>
        <name evidence="10" type="ordered locus">orf19.7118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
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        <property type="gene designation" value="orf19.7118"/>
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    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADK_active_lid_dom_sf"/>
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        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>AMP</name>
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        <ligand>
            <name>AMP</name>
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            <begin position="92"/>
            <end position="95"/>
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        <ligand>
            <name>AMP</name>
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        </ligand>
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        <ligand>
            <name>AMP</name>
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            <position position="133"/>
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        <ligand>
            <name>GTP</name>
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            <end position="143"/>
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        <ligand>
            <name>AMP</name>
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        <ligand>
            <name>AMP</name>
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        <ligand>
            <name>GTP</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="222" mass="25173" checksum="29F456EADD76639F" modified="2017-01-18" version="1">MNPLRILLLGAPGSGKGTQTSRLLKRFTQLQSLSSGDILRNQIRSGSAIGGEAQTYIKNGSLVPDNIMVGLITAELEKKKWLTQSSSWLLDGFPRTVNQARELDRVIHDRANFNLVVELDVDQKVILQRIEARWIHEASGRVYNLDYNPPKVPFKDDVTGEALTKRQDDTAQVFQKRLDQYNEEIEPLKVFYKQQGLLYTVSGDTSDIIYPKLENLIVDKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR82</accession>
    <name>A0A1D8PR82_CANAL</name>
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        <recommendedName>
            <fullName evidence="13">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C702960CA</name>
        <name evidence="10" type="ordered locus">orf19.12632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716987.2">
        <property type="nucleotide sequence ID" value="XM_711894.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR82"/>
    <dbReference type="SMR" id="A0A1D8PR82"/>
    <dbReference type="FunCoup" id="A0A1D8PR82">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PR82"/>
    <dbReference type="GeneID" id="3641387"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702960CA"/>
    <dbReference type="CGD" id="CAL0000182460">
        <property type="gene designation" value="orf19.12632"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02960C_A"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PR82"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140827">
        <property type="term" value="F:zinc chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034224">
        <property type="term" value="P:cellular response to zinc ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="306"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000182460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41572" checksum="267ACC6BA2D6B7C4" modified="2017-01-18" version="1">MDEIPELVTELPENGVIKTEKVPAAPFVPSSSTPTALAKKIPITIVTGYLGSGKSTLLQNIGKTANKRLAIILNEFGDSSVIEKSVTIQDQDDSVQEWLDIGNGCLCCTVKDNGVTAIENLIENSKDKIDYILLETTGVADPAPIAKMFWLDEGLASNIYIDGVVTVVDAEHITKCLDDVGGHWHKESLGEDVEFEDGITTAHLQLALADVILLNKIDKVSDTQPMTQRIRQINQTSPIHTTSFGDIEISKILDLHAFDVDAKLTTSETSFHDDRISTVTITFPFLENEEGFSKVENFLQHVLWDNFVNGKNVEVHRMKGLLVHGNDVRVVQGVRDTYEIIENGKLLEEVKENKLVFIGKNLHRPDLQEELSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRF4</accession>
    <name>A0A1D8PRF4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C703850WA</name>
        <name evidence="9" type="ordered locus">orf19.7197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715245.1">
        <property type="nucleotide sequence ID" value="XM_710152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRF4"/>
    <dbReference type="SMR" id="A0A1D8PRF4"/>
    <dbReference type="FunCoup" id="A0A1D8PRF4">
        <property type="interactions" value="1169"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRF4"/>
    <dbReference type="GeneID" id="3643145"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703850WA"/>
    <dbReference type="CGD" id="CAL0000177493">
        <property type="gene designation" value="orf19.7197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03850W_A"/>
    <dbReference type="eggNOG" id="KOG2153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRF4"/>
    <dbReference type="OMA" id="HYCPQVR"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="145"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="535"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000177493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="745" mass="85453" checksum="430218CF3B195FD9" modified="2017-01-18" version="1">MAKRKSKQQDLEKKKKLKQSQDEQLSTGLFNNVGQGQHQGDDDDEEGDEIDWDNQEMDYELIPRKITTKKTIEALPIKKSDGTIERVVREVEEEEEEEEEEEPEEEPELENDVENEPSKQENKENKEEGDIDTDDTLTPQEKLIQTKEEIAELGSKLIEDPEENIVCLTRLRKMSESKNFMTSQLSILALIPIFKSLAPSYKIRPLTDTEKREKVSREIAKLRNFEQNLVINYKAYIELLTKYSKISYSNSMNNNKITSDQLKRGNIALKAATELCLSSLRHFNFREELFTIIIKRLNKKPQHQQDYPIFIKSLRVLETLLKDDAEHGDITFDIIKIMTKSIKDKKFRVDESVVNVFLSISLLEDYDPNNNNNNKDDHHNTTLKPKLKKKDRIHLSKKERKARKERKEIEEEIQKAEQAITVEQREKYQAQVLKMVLTLYLEILKAGSSSSQLIDGDGKKTKNDASLLMGAVLEGLSRFGQMSNLDLLGDFLEVLREIMTDIIEEHKQSGDNDNDNDNDDESGGMYSGNELRTILLCIATSFSLVLNHNSMGKLPMAIDLSKFVSTLYIILTDLALDPDLEFSHKTLRLADPLSSSSLSNELENNKPAVNVSTKAELLLRCLDFIFFRSKNGTIPRATAFIKRLYILTLQTPEKTSLANLKFIGKLMNRYGENIKGLWNTEERISGEGNYILGIERQNKDKDVELERSNSGAATLWENVLLDKHYSIMIKDGSRSLMKNSKANTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRW9</accession>
    <name>A0A1D8PRW9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Boi2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">BOI2</name>
        <name evidence="9" type="ordered locus">CAALFM_CR01240CA</name>
        <name evidence="8" type="ordered locus">orf19.10740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PSD4_CANAL</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSH3</accession>
    <name>A0A1D8PSH3_CANAL</name>
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        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="5 6" type="primary">CIT1</name>
        <name evidence="6" type="ordered locus">CAALFM_CR03500WA</name>
        <name evidence="5" type="ordered locus">orf19.11871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the citrate synthase family.</text>
    </comment>
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        <property type="component" value="Chromosome R"/>
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        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Citrate Synthase, domain 1"/>
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        <property type="entry name" value="Citrate_synthase"/>
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        <property type="entry name" value="Citrate_synthase_AS"/>
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        <property type="entry name" value="Citrate_synthase_euk"/>
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        <property type="entry name" value="Citrate_synthase_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="467" mass="52001" checksum="7D1385C0496921BF" modified="2017-01-18" version="1">MSAFRSIQRSTNVAKSTFKNSIRTYASAEPTLKQRLEEILPAKAEEVKQFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPIEGIRFRGRTIPDIQKELPKAPGGEEPLPEALFWLLLTGEVPTDAQTKALSEEFAARSALPKHVEELIDRSPSHLHPMAQFSIAVTALESESQFAQAYAKGANKSEYWKYTYEDSIDLLAKLPTIAAKIYRNVFHDGKLPAAIDSKLDYGANLASLLGFGDNKEFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPFLSLAAGLNGLAGPLHGRANQEVLEWLFKLREELNGDYSKEAIEKYLWETLNSGRVVPGYGHAVLRKTDPRYTAQREFALKHMPDYELFKLVSNIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEQSFYTVLFGVSRAFGVLPQLILDRGIGMPIERPKSFSTEKYIELVKNINKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSP5</accession>
    <name>A0A1D8PSP5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAALFM_CR04110WA</name>
        <name evidence="13" type="ordered locus">orf19.8124</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex. Acts as a competitive binder for CBF5 probably required to prevent non-cognate RNAs from being loaded during transport of the particle by inducing a non-productive conformation of CBF5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains CBF5, NAF1, NHP2 and NOP10 proteins. Interacts with SHQ1. Interacts directly with CBF5. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (RPB1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717357.2">
        <property type="nucleotide sequence ID" value="XM_712264.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSP5"/>
    <dbReference type="SMR" id="A0A1D8PSP5"/>
    <dbReference type="STRING" id="237561.A0A1D8PSP5"/>
    <dbReference type="GeneID" id="3641026"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04110WA"/>
    <dbReference type="CGD" id="CAL0000196049">
        <property type="gene designation" value="orf19.8124"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04110W_A"/>
    <dbReference type="eggNOG" id="KOG2236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSP5"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="446"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000196049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW31149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="581" mass="66022" checksum="968CCA7529517857" modified="2017-01-18" version="1">MSESTNQQETALREIVEDTTNANEPTAIDKTTLPNETSHERETTTTENASSEIENIEPQVATHNSDLDKSIPTDTNIISDVSQAPHVCPDNENTVQTSEDLQQSNVEKQKMEFHNGLEQSKEMATETEIEKFDDIQREISDPIDDESLKSTQKPESLETEKVEADASHKGLADEAEQLSDEEINVDDISSDDNSESSSSEESSGDSSSDESSDENETSNIDYNDVEDEDEDSNEGPVKSVHEIIDEKAPSLPDNYEISPNTPIEEIGEITGLVENTMIIKARTSGEFRILQEKSIFCFEDRTVIGPLFEIFGRVQQPVYSVKFNSEEQFSKFKESKGKTVYYVVPDSQFLYTDSIKHIKGTDASNCHDEELPEEEQEYSDDEKESAAKSAKKKKKNKKTKDKQTHTSGPSLPNKRQKVSAYSPITTYSQNAVHNRGRQISPQHNTIYSNYGQQQPPQQQQQQSPPVAQYGQPYYPQTDSYNSLMGQTPQYPQPTFGQSQHFYQNAYNQPVQPQYEPAYQPPQQYNQYQQQPQEQQQQQQFNPNMPNAQTQQQVDPAQLEHLQRLLLQHLQNNQNQYQHPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSU2</accession>
    <name>A0A1D8PSU2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">PNP/PMP oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">PDX3</name>
        <name evidence="19" type="ordered locus">CAALFM_CR04590CA</name>
        <name evidence="18" type="ordered locus">orf19.8185</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717413.1">
        <property type="nucleotide sequence ID" value="XM_712320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSU2"/>
    <dbReference type="SMR" id="A0A1D8PSU2"/>
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        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PSU2"/>
    <dbReference type="GeneID" id="3640949"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04590CA"/>
    <dbReference type="CGD" id="CAL0000195497">
        <property type="gene designation" value="PDX3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_04590C_A"/>
    <dbReference type="eggNOG" id="KOG2586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSU2"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000010">
        <property type="entry name" value="Pyridoxine phosphate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="16">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="17">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000195497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW31195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="269" mass="31275" checksum="595E29E82AF92806" modified="2017-01-18" version="1">MFKQVVSKNRIPIENSIASIRKMTLNSTSANPDTRREDPETTTQEPIIFAPATYQYTKGHLGDTEVDKDPLAQFNKWFKEAQDNLPANSDIIVEATNFSTARLPSGRVSSRIVLLKELDKYGFLVYSNWNTSKKAKDFESNKYASLTFFWPHVQRQVRVEGIMEHVTRETSERYFNTRPRGSKIGAWASPQSSVVQSRDDLDQIKDKYNDKFKDLQDHEIPCPDYWGGIRIEPLEVEFWQGGLSRLHDRITYRREKKEDPNWEIVRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU23</accession>
    <name>A0A1D8PU23_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_CR09830WA</name>
        <name evidence="8" type="ordered locus">orf19.7554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719316.1">
        <property type="nucleotide sequence ID" value="XM_714223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU23"/>
    <dbReference type="STRING" id="237561.A0A1D8PU23"/>
    <dbReference type="GeneID" id="3638986"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09830WA"/>
    <dbReference type="CGD" id="CAL0000178856">
        <property type="gene designation" value="orf19.7554"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09830W_A"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU23"/>
    <dbReference type="OMA" id="ISYTGHY"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000178856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="560" mass="61857" checksum="F603A31C5C305804" modified="2017-01-18" version="1">MVSNTLPEHESNTSLHDMEKKQLADQLGDIHYKILPIKKLLICLFSLSLALFLSFVDQTSVTIALATIGKDLNAETTINWAPTASLLANCICQVLFGRLSDIFGRKVMLITCLICLSLGELICSFAKSGVEFFVFRALTGLSCGGIQSLCMVILSDVVTLKQRGKYQGILGASVGLGNSIGPFMMAAFIEHNTWRNFYRMMCPINILAFVIIAIFIDTKQQTKQLNQLLSKSEQFKKLDYLGMLIGCSGLTLLLVSISSGGSTYNWNSAPVISMFVIGGILLITFLFVEWKVPELPMIPLNLFSRFSLGLILGSNFFFGMAYYGFTFYIAYYYQIVLGLDSIHSAILMLPLVIPQSVVSAIAGQIISYTGHYIYVIIFGYSLWTLSCGLTLLFDSNTNYGVITVVLLLMGTGVACTFQPTMVAAQSQAKKSERAVVISCRNVIRSLGGAVGLAVASLIITNSLLKEITKQENRQDISSTSSVPTGYLMYLKTHVYSKVDTTQLTADQVLIVRQMYMQAIRNFFYLTIPLLALCLISSLFVKDKGLQCIDEEPEKEEKELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU57</accession>
    <name>A0A1D8PU57_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomutase-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_CR10200WA</name>
        <name evidence="2" type="ordered locus">orf19.7596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW31728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_714336.1"/>
    </dbReference>
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        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PUA3"/>
    <dbReference type="GeneID" id="3638948"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10800CA"/>
    <dbReference type="CGD" id="CAL0000176657">
        <property type="gene designation" value="orf19.7670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10800C_A"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PUA3"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="239"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="523"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="767"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000176657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW31728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="923" mass="104155" checksum="4AEA339D4F242F03" modified="2017-01-18" version="1">MSNTPIQGSSSKPNVAAEDYSRSSSRTNISSVRNRSATRMKKNSRPNLKRLGSVSHPQGLVYSVDDDINENDKDDSTKESEPKSDRDYLEGYNDALRALSNRKGRTSSGHLSIAGTPLRSPEEIATIESKLAKDLTDAEEQMRLLEDLDSGPTPNVTDEFVEPEDNNEDAGSIKSTSTVESLNLKERQNAINSTHPFGIKIWKPSLYKKKRSVATRAEEDIHDFDPRKPTARIYWGVKLTNIVWSLTAGLLICLICLLGAAFVFIFSGFAIERKSRPYVKALLKLGHYWLYPFGKFVLLNREQNYLDEDQLEGRTINEFHQWRLQEEGRLFFAPPRRYTGSESTRPLLKDHRGRPLRDAYSSLDDGIQEEEDEQDNDANDIKVRFFGRGDWSFGRIAFYVYFYGIIQPISFFIGILCWLIVFTIPMAKITNTMNDHMRRHPLALDYELEKDYYKRVERTPRKKNQVILLCTYRCCGFHYYKYTIDGTNIFFINLLSVVIFAILDYYFLKETMHWDSWITESNFIFCLSLFSIIPLAYFIGQAVASISAQSSMGVGAVINAFFSTIVEIFLYCVALNQAKGKLVEGSMIGSILGAVLLLPGLSMCGGAFKRKTQRYNPRSAGVSSTMLSYAMVVMFAPSIFYQMYGSYEMKCKDCTSPGVCGRCRFIQPTFVLDSLYSTVIKPFSLIVTVALFAAYVCGLFFTLRTHASLIWATTSHEPKRDDYFRSNSVVSMSTPTQTPKPTTPLPAKPEEDQGGGHDAPNWSRSKSTIILLGATILYAIIAEILVDNVDSILADFPINPKFLGLTVFALVPNTTEFLNAISFAVGGNVALSLEIGSAYALQVVLIQIPCLVLYSIYQNFENVEQTFTLIFPSWDIIATLISIYLFTYIYAEGKSNYFKGVILILIYVVVLSGFWFNDIIDSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>P0C0X3</accession>
    <accession>A0A1D8PE18</accession>
    <name>TFB5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>General transcription and DNA repair factor IIH subunit TFB5</fullName>
            <shortName>TFIIH subunit TFB5</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>RNA polymerase II transcription factor B subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TFB5</name>
        <name type="ordered locus">CAALFM_C107280CA</name>
        <name type="ORF">CaO19.11919.1</name>
        <name type="ORF">CaO19.4439.1</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330670.1">
        <property type="nucleotide sequence ID" value="XM_019475125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0C0X3"/>
    <dbReference type="SMR" id="P0C0X3"/>
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        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P0C0X3"/>
    <dbReference type="EnsemblFungi" id="C1_07280C_A-T">
        <property type="protein sequence ID" value="C1_07280C_A-T-p1"/>
        <property type="gene ID" value="C1_07280C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515021"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107280CA"/>
    <dbReference type="CGD" id="CAL0000181098">
        <property type="gene designation" value="orf19.4439.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07280C_A"/>
    <dbReference type="eggNOG" id="KOG3451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="P0C0X3"/>
    <dbReference type="OMA" id="IYNPMDE"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000119278" description="General transcription and DNA repair factor IIH subunit TFB5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q3E7C1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="69" mass="7767" checksum="FB2E15632254DA25" modified="2006-01-10" version="1">MLVASKGVLVQCDPSIKALIIQIDSSSSGIILEELDETHLLIQHDKVNFVKSELNRLLSKNIYNPFEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LF2</accession>
    <accession>A0A1D8PQB6</accession>
    <name>ALG2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="1">2.4.1.132</ecNumber>
            <ecNumber evidence="1">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG2</name>
        <name type="ordered locus">CAALFM_C604030WA</name>
        <name type="ORF">CaO19.1221</name>
        <name type="ORF">CaO19.8808</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="1"/>
    <dbReference type="EC" id="2.4.1.257" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710571.2">
        <property type="nucleotide sequence ID" value="XM_705479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LF2"/>
    <dbReference type="SMR" id="Q59LF2"/>
    <dbReference type="FunCoup" id="Q59LF2">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LF2"/>
    <dbReference type="GlyCosmos" id="Q59LF2">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_04030W_A-T">
        <property type="protein sequence ID" value="C6_04030W_A-T-p1"/>
        <property type="gene ID" value="C6_04030W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647832"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604030WA"/>
    <dbReference type="CGD" id="CAL0000176395">
        <property type="gene designation" value="ALG2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04030W_A"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_1_0_1"/>
    <dbReference type="InParanoid" id="Q59LF2"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="PRO" id="PR:Q59LF2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033164">
        <property type="term" value="F:initiation-specific glycolipid 1,6-alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000222">
        <property type="entry name" value="Alpha-1,3-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000659">
        <property type="entry name" value="Alpha-1,3/1,6-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000080263" description="Alpha-1,3/1,6-mannosyltransferase ALG2">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P43636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="443" mass="50457" checksum="5B23EDA7B0288791" modified="2017-03-15" version="2">MSKRQENKKIAFIHPDLGIGGAERLVVDAAVGLQDFGHDIIIYTSHCDLTHCFEEVSSGQLKVSVHGDSLPTNLFGKLHIFFAILRQFYLVCWLIFTGTIKNYDYFIVDQLSFCIPLLKMFCNSNCQVLFYCHFPDQLLVRRTSFLKKLYRVPFDAIEEYTTGSSDQIVVNSNFTKQIFHDTFKKLNHIDPQVVYPCVDTETIVDTNASSNSEVSKFFKDSPFFLSINRFERSKNIELAIKSFARMNKLMVTKAIKSFARMNKLMVTNKKPRLVIAGGYDSRVAENVEYLAELSTLCDELNLINFTIRGKLIMMPPSVDVLFLPSISTQLKNSLIQQTELLLYTPPREHFGIVPLEAMLAKTPVLAINFGGPLETVVNYNGNNLDEATGYTETGDFTKWSKIIMKHYNLDESTKIKLGENGRNRVINKFSRKKLAQSLDNILN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LP6</accession>
    <accession>A0A1D8PJ55</accession>
    <name>AIM11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM11</name>
        <name type="ordered locus">CAALFM_C300840CA</name>
        <name type="ORF">CaO19.6156</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710638.1">
        <property type="nucleotide sequence ID" value="XM_705546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LP6"/>
    <dbReference type="SMR" id="Q59LP6"/>
    <dbReference type="FunCoup" id="Q59LP6">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C3_00840C_A-T">
        <property type="protein sequence ID" value="C3_00840C_A-T-p1"/>
        <property type="gene ID" value="C3_00840C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647758"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300840CA"/>
    <dbReference type="CGD" id="CAL0000201599">
        <property type="gene designation" value="orf19.6156"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00840C_A"/>
    <dbReference type="eggNOG" id="ENOG502SAK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118700_0_0_1"/>
    <dbReference type="InParanoid" id="Q59LP6"/>
    <dbReference type="OMA" id="RFAYKST"/>
    <dbReference type="OrthoDB" id="4088121at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000405642" description="Altered inheritance of mitochondria protein 11">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="165" mass="18562" checksum="5E52A37E0DD48210" modified="2005-04-26" version="1">MSDLLHKLNFKIADASPEYKQRRKIQMIRFFTASAVTIFASRFAYRATVSRQYIPTLFQGNHSPPLSYNFTTDAAVAVGTGTLLCGSVTGMTVFGLCWILDVSNIKEFGWRMKSMLGGWESEKKLSEAPMDEESSYIQDSLNDILDGKYDFENDTEEVAGELKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LQ6</accession>
    <name>Q59LQ6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor eIF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">SUI1</name>
        <name evidence="7" type="ordered locus">CAALFM_C504090CA</name>
        <name evidence="6" type="ordered locus">orf19.8867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710661.1">
        <property type="nucleotide sequence ID" value="XM_705569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59LQ6"/>
    <dbReference type="SMR" id="Q59LQ6"/>
    <dbReference type="FunCoup" id="Q59LQ6">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59LQ6"/>
    <dbReference type="GeneID" id="3647730"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504090CA"/>
    <dbReference type="CGD" id="CAL0000195380">
        <property type="gene designation" value="SUI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_04090C_A"/>
    <dbReference type="eggNOG" id="KOG1770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_3_2_1"/>
    <dbReference type="InParanoid" id="Q59LQ6"/>
    <dbReference type="OMA" id="CEFMITQ"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000195380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="109" mass="12340" checksum="E899CB073C75294D" modified="2005-04-26" version="1">MSTIQNLNAFDPFADTGDSEAQPTNYIHIRIQQRNGRKTLTTVQGVPNEYDLKKILKVLKKDFACNGNIVKDDELGEVIQLQGDQRVKVSEFLTAQLQLPKKNIKIHGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NN8</accession>
    <accession>A0A1D8PPG6</accession>
    <accession>Q59NT5</accession>
    <name>FES1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FES1</name>
        <name type="ordered locus">CAALFM_C600760WA</name>
        <name type="ORF">CaO19.11133</name>
        <name type="ORF">CaO19.3649</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711322.2">
        <property type="nucleotide sequence ID" value="XM_706230.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NN8"/>
    <dbReference type="SMR" id="Q59NN8"/>
    <dbReference type="FunCoup" id="Q59NN8">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59NN8"/>
    <dbReference type="EnsemblFungi" id="C6_00760W_A-T">
        <property type="protein sequence ID" value="C6_00760W_A-T-p1"/>
        <property type="gene ID" value="C6_00760W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3647080"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600760WA"/>
    <dbReference type="CGD" id="CAL0000195916">
        <property type="gene designation" value="orf19.11133"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00760W_A"/>
    <dbReference type="HOGENOM" id="CLU_046722_1_0_1"/>
    <dbReference type="InParanoid" id="Q59NN8"/>
    <dbReference type="OMA" id="LHWSIAN"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="PRO" id="PR:Q59NN8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001713">
        <property type="entry name" value="Hsp70 nucleotide exchange factor FES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="284" mass="31833" checksum="BC7A8988DAB76ED0" modified="2017-03-15" version="2">MEKLLHWTIAQQSGDKAALEKIGEPDQKALNQLFGGPDEATLMKESIKVVESTDVSLEDKEIALENFEMLIENLDNANNIGNLKLWNPLIDILAKEDTPVELKVLICGIIGTAVQNNPKSQEDFNETEGLSELIELAQDDKKFELQSKALFAISSFIRNFQPGYAKFEKLQGLKLINFDNKNNKYQLRILSLISSILSNGLDDSLKAQFKEAKLPHYLASVLNEDSNTSLVDKSLNIVSQLNQLNYEFSLEEKYEINRGIQVVEGLSEKLNIDDLNNAKQATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q59P94</accession>
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        <name evidence="14" type="ordered locus">orf19.8998</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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</entry>
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        </submittedName>
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        <lineage>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
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                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Weissman J.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="173" mass="19799" checksum="DE8FB7626B4A115A" modified="2005-04-26" version="1">MNMNAKNIRWVEPPATIIDETIMNSSVPEADFPVKPILKLPRNTPFPFASEDDNKESEDQEDLNKTKQISNLLRNHFICIMKSIFGLIKMLINNQIITGFTNFLISAIAFISITALRIIAAVGRFLIDFDFSLFFESCSFLLEEHELYFTTDLSHQHPNRKSNKRRVTTTAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q59RI7</accession>
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        <recommendedName>
            <fullName evidence="4">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
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        <name evidence="1" type="ordered locus">orf19.9679</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712407.1">
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    </dbReference>
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    <dbReference type="SMR" id="Q59RI7"/>
    <dbReference type="STRING" id="237561.Q59RI7"/>
    <dbReference type="GeneID" id="3645986"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604480CA"/>
    <dbReference type="CGD" id="CAL0000199404">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04480C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQ4B">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102252_0_0_1"/>
    <dbReference type="InParanoid" id="Q59RI7"/>
    <dbReference type="OMA" id="ISTHEMP"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000199404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26227" checksum="6BB5C61E9EE4776B" modified="2005-04-26" version="1">MIVELHSDVLLHVSDLFARGVENKLGLLLGYGLDDRLVVVKPIELAQVDPQYLEKRYSLFKDVYPNLSIVGVYEIGGNNPDRANILDIPAGRILYVSVDHNIQFKSFIDGDLVKTVIESSETEVIATKTIDTNKEYTKGRPKDELTVAEFNQNMVNTLTKLYERLTKILETKGMDKEIVEIANALRCYKHVKQSTDMKLQAAELALITEQIAELERTKIGIAKKILVKEPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Clg1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">CLG1</name>
        <name evidence="2" type="ordered locus">CAALFM_CR07240CA</name>
        <name evidence="1" type="ordered locus">orf19.13565</name>
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    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712352.1">
        <property type="nucleotide sequence ID" value="XM_707259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59RN8"/>
    <dbReference type="SMR" id="Q59RN8"/>
    <dbReference type="STRING" id="237561.Q59RN8"/>
    <dbReference type="GeneID" id="3646030"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07240CA"/>
    <dbReference type="CGD" id="CAL0000194840">
        <property type="gene designation" value="CLG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07240C_A"/>
    <dbReference type="eggNOG" id="ENOG502RYK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106980_0_0_1"/>
    <dbReference type="InParanoid" id="Q59RN8"/>
    <dbReference type="OMA" id="TNKSWEQ"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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    </dbReference>
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        <property type="project" value="CGD"/>
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        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000194840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="251" mass="29334" checksum="71935E0703D63FF5" modified="2005-04-26" version="1">MDKEYQEYQISDMPSFIGWACHGILKQNRTTSEFLLNSTQSLLFSTRLSIPTILAGLEYINQRFSNKEIYHLQDQEIFQILVVSFLLSNKMNDDATFTNKSWEQASGIPLSVLNREEREWLNEVKFNLAVTKYEANISVLDQCWKTWVNKYGSCHSEPPSSPTYYTPEVDAYYYSSHHHSYSSPISYSQHSYSNPYPQHQQCNYQYQYQPQYQPTYQSHTQYLVPQPPPPPPPSYYDPAIVSVNYGGFIYT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S64</accession>
    <name>HRR25_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine protein kinase HRR25</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Casein kinase I homolog HRR25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HRR25</name>
        <name type="ordered locus">CAALFM_C602340WA</name>
        <name type="ordered locus">orf19.10980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2022" name="IScience" volume="25" first="104432" last="104432">
            <title>Functional analysis of the Candida albicans kinome reveals Hrr25 as a regulator of antifungal susceptibility.</title>
            <authorList>
                <person name="Lee Y."/>
                <person name="Liston S.D."/>
                <person name="Lee D."/>
                <person name="Robbins N."/>
                <person name="Cowen L.E."/>
            </authorList>
            <dbReference type="PubMed" id="35663022"/>
            <dbReference type="DOI" id="10.1016/j.isci.2022.104432"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Serine/threonine protein kinase that acts as a key mediator of drug resistance (PubMed:35663022). Is a key modulator of cell wall and cell membrane stress tolerance (PubMed:35663022). Involved in the regulation of tolerance to both antifungals as well as target-mediated echinocandin resistance through its interaction with the SBF transcriptional factor complex (PubMed:35663022).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Impairs viability (PubMed:35663022). When expression is controlled in a dose-dependent manner, transcriptional repression confers over 8-fold hypersensitivity to caspofungin and 4-fold hypersensitivity to fluconazole (PubMed:35663022).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712515.1">
        <property type="nucleotide sequence ID" value="XM_707422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S64"/>
    <dbReference type="SMR" id="Q59S64"/>
    <dbReference type="FunCoup" id="Q59S64">
        <property type="interactions" value="1089"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59S64"/>
    <dbReference type="EnsemblFungi" id="C6_02340W_A-T">
        <property type="protein sequence ID" value="C6_02340W_A-T-p1"/>
        <property type="gene ID" value="C6_02340W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645878"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602340WA"/>
    <dbReference type="CGD" id="CAL0000187651">
        <property type="gene designation" value="HRR25"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02340W_A"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="InParanoid" id="Q59S64"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000370">
        <property type="term" value="P:positive regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090033">
        <property type="term" value="P:positive regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000785">
        <property type="term" value="P:regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001159">
        <property type="term" value="P:regulation of protein localization by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106214">
        <property type="term" value="P:regulation of vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000463447" description="Serine/threonine protein kinase HRR25">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35663022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="35663022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="35663022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="433" mass="50488" checksum="E688D1E72D96704C" modified="2005-04-26" version="1">MDLRVGKKYRIGRKIGSGSFGDIYLGTNIISGEEVAIKLENTKAKHPQLEYEAKVYKALSGGVGIPFVRWYGTECDYNAMVIDLLGPSLEDLFNYCNRKFTYKTVLLLADQLICRIEYIHARCFIHRDIKPDNFLMGIGRRGSQVNVIDFGLAKKYRDPRTHLHIPYRENKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCRGSLPWQGLKAATKRQKYDRIMEKKMTTPNNILCKGLPSEFLEYMNYVKTLRFDDKPDYPYLRKLFRDLFKKENYRYDYVFDWTLYKFQQEKQRAQQGKVADGDNQDQQQQQNNQNQTQTQNQQGQITAPQPPVPVSQQQQQQQQIPQHIPTPQQISQQQQQQQQQQQQLPPQQQKTSVTPQLQQYTDQRLQNQRAVYQSNQNYSGTKSAQPQAQQPPQQGNPAWL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S85</accession>
    <accession>A0A1D8PPV1</accession>
    <name>LPE10_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial inner membrane magnesium transporter LPE10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LPE10</name>
        <name type="ordered locus">CAALFM_C602150CA</name>
        <name type="ORF">CaO19.10959</name>
        <name type="ORF">CaO19.3455</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms homooligomers. Interacts with MRS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712495.2">
        <property type="nucleotide sequence ID" value="XM_707402.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S85"/>
    <dbReference type="SMR" id="Q59S85"/>
    <dbReference type="FunCoup" id="Q59S85">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_02150C_A-T">
        <property type="protein sequence ID" value="C6_02150C_A-T-p1"/>
        <property type="gene ID" value="C6_02150C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645888"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602150CA"/>
    <dbReference type="CGD" id="CAL0000183380">
        <property type="gene designation" value="orf19.10959"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02150C_A"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_1_0_1"/>
    <dbReference type="InParanoid" id="Q59S85"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="PRO" id="PR:Q59S85"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000056">
        <property type="entry name" value="Mitochondrial inner membrane magnesium transporter LPE10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043236" description="Mitochondrial inner membrane magnesium transporter LPE10">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="YGMN">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q02783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="453" mass="51091" checksum="D637CD86460DCEAA" modified="2017-03-15" version="2" precursor="true">MIPIRSSITRILPNGFLSKPFLRQLNKKSKPNPHKNKNFDSFNEVFIHKTLLSSIKQHNDTDYVRCSIFNANGDMIQHGKEILKSQFIKRYNLTPRDFRKFNWQRSATGTTTTSSSSSSSAGQTSSGTSKSSSSSSSSSSPHSTISALSLSNSSLGSSTNVDIVPNITIRRNSILVQLLNIRALINHDQLIIFDNSSSFQNSHVSSYTHSQCLKDLSQRLKSTNLDGLPFEFKALEGILIYIVSNLNMEMKVHNTVLQNIITGLEDSIDRNKLRYLLIESKKIHQFHRKITLIKNCLEDLLENDDELNDLYITEKFNSEGDGQPRQGTNHEEIEMLLENYYQTIDEIVQIVENLKNQIKTTEDLINVVLDSNRNQLMLLGLKFSTGLLSMGVALYVSALYGMNLENFIEEIDGGFEVVTVVSTIALIALLLFSVKQLKKVEKVTMTSLNDQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TZ8</accession>
    <name>Q59TZ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">GLK1</name>
        <name evidence="12" type="ordered locus">CAALFM_CR07150WA</name>
        <name evidence="11" type="ordered locus">orf19.7686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710176.2">
        <property type="nucleotide sequence ID" value="XM_705084.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TZ8"/>
    <dbReference type="SMR" id="Q59TZ8"/>
    <dbReference type="FunCoup" id="Q59TZ8">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59TZ8"/>
    <dbReference type="GeneID" id="3648348"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR07150WA"/>
    <dbReference type="CGD" id="CAL0000189805">
        <property type="gene designation" value="GLK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_07150W_A"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_0_1"/>
    <dbReference type="InParanoid" id="Q59TZ8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:10644"/>
    <dbReference type="PHI-base" id="PHI:8971"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="225"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000189805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="472" mass="52108" checksum="D34E63A631143BAB" modified="2005-04-26" version="1">MSLSPKLEEIVSSIEKSFEIKDDFLVKATEYFIESMNVGLESPKPSKDVMPMIPTYVTSIPTGKEVGLYLAADLGGTNFRVCSIDLKGDHTFSMKQSKYRIPVDLMKAEKSNDLFGFLAKKVQSFLLENHSEACTAKNTEPLKLGFTFSFPVNQTALNRGTLIRWTKGFDIPDTVDRDVVELLQANLTILEVNVKVVAIANDTVGTLLTAAYSNDSAKTNRNTIIGCIFGTGTNGAYFESKIPKLSSSTGKSQGMVINTEWGSFDNGLKILPSTEFDEIVDSETANPGYHLFEKRISGMFLGEILRVALIHLFKKGLIFQELYKARGGSLPHRIEEPWLLDAEVLSYLQIDDSTDLKTSGLILQNVLRLETNKEEREVIQRLTRAISQRAAHLSAIPIAAIAKKVKDQYKDDDRDFEVGCDGSVIEFYPGFRQAVLESIEKINPLKGTNKKIHLKIAKDGSGVGAALCASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q59U59</accession>
    <name>Q59U59_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartate protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">APR1</name>
        <name evidence="17" type="ordered locus">CAALFM_C207400CA</name>
        <name evidence="16" type="ordered locus">orf19.9447</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
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        <property type="entry name" value="Aspartic_peptidase_A1"/>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
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        <property type="entry name" value="PEPSIN"/>
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    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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            <begin position="23"/>
            <end position="419"/>
        </location>
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    <sequence length="419" mass="45447" checksum="A25967D2564AA23F" modified="2005-04-26" version="1">MQLSLSALTTVALALTSSLVDAKAHSIKLSKLSNEETLDASNFQEYTNSLANKYLNLFNTAHGNPSNFGLQHVLTNQEAEIPFVTPKKGGKYDAPLTNYLNAQYFTEIQIGTPGQPFKVILDTGSSNLWVPSQDCTSLACFLHAKYDHDASSTYKVNGSEFSIQYGSGSMEGYISQDVLTIGDLVIPGQDFAEATSEPGLAFAFGKFDGILGLAYDTISVNHIVPPIYNAINQGLLEKPQFGFYLGSTDKDENDGGLATFGGYDASLFQGKITWLPIRRKAYWEVLFEGIGLGDEYAELHKTGAAIDTGTSLITLPSSLAEIINAKIGATKSWSGQYQVDCAKRDSLPDLTLTFAGYNFTLTPYDYILEVSGSCISVFTPMDFPQPIGDLAIVGDAFLRKYYSIYDLDKNAVGLAPSKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VF4</accession>
    <accession>A0A1D8PDC8</accession>
    <name>HAT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HAT1</name>
        <name type="ordered locus">CAALFM_C104670WA</name>
        <name type="ORF">CaO19.779</name>
        <name type="ORF">CaO19.8401</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 3">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713589.1">
        <property type="nucleotide sequence ID" value="XM_708496.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VF4"/>
    <dbReference type="SMR" id="Q59VF4"/>
    <dbReference type="FunCoup" id="Q59VF4">
        <property type="interactions" value="1199"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59VF4"/>
    <dbReference type="EnsemblFungi" id="C1_04670W_A-T">
        <property type="protein sequence ID" value="C1_04670W_A-T-p1"/>
        <property type="gene ID" value="C1_04670W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644770"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104670WA"/>
    <dbReference type="CGD" id="CAL0000199484">
        <property type="gene designation" value="HAT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04670W_A"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="InParanoid" id="Q59VF4"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="PHI-base" id="PHI:5282"/>
    <dbReference type="PRO" id="PR:Q59VF4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043997">
        <property type="term" value="F:histone H4K12 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043995">
        <property type="term" value="F:histone H4K5 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043996">
        <property type="term" value="F:histone H4K8 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000221">
        <property type="term" value="P:negative regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036166">
        <property type="term" value="P:phenotypic switching"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="Hat1_N_sf"/>
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        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
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        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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    <feature type="chain" id="PRO_0000227719" description="Histone acetyltransferase type B catalytic subunit">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
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        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
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    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="UniProtKB" id="O14929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="413" mass="48355" checksum="94B7ACA991EA8747" modified="2005-04-26" version="1">MSSAKEQSSVTAALQPEQWTTSSNEALKLFVTNPEAALNFQPTFTYPIFGDAETIYGYKDLDIFLCFDHYTFKPFLNIKYSAKLTDDPEIIDIKKTIDEFLPKSTIFKDEVKWVDSIKEEKDNGYKIPGKLIDSFSENDKEYDIYKIDLKSDNGYELHQRLQILVLLFIEAGSFIDAKDELWNLYVLYEKDNKSTSNNEPSIVGFTTAYNYWKYPGAKKFDSTEQESRIKISQFIILPIYQGQGLGQLFYSHLFDKWLAQDDIIEVVVEDPNESFDDLRDRADLKRLNTSEQFDFKAVTPKVDKEWVEKTRRALKLEKRQFARLLEIILLYKLKHGYPGITKRDVRLFIKKRLYDKNKEGLATLDDNTKKDKLQTAYQALEDDYYRILGDLKLNIKRENDEEETDTVSKKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Z47</accession>
    <name>Q59Z47_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">CAALFM_C206990WA</name>
        <name evidence="3" type="ordered locus">orf19.9793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714843.1">
        <property type="nucleotide sequence ID" value="XM_709750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Z47"/>
    <dbReference type="STRING" id="237561.Q59Z47"/>
    <dbReference type="GeneID" id="3643531"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206990WA"/>
    <dbReference type="CGD" id="CAL0000184454">
        <property type="gene designation" value="orf19.9793"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06990W_A"/>
    <dbReference type="eggNOG" id="ENOG502S0ZE">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042296_0_0_1"/>
    <dbReference type="InParanoid" id="Q59Z47"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
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        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000184454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="518" mass="58858" checksum="1BF9E68D25DA50CC" modified="2005-04-26" version="1">MVVSDYSATQGLMALLYSLNKGATTGTGIKKLVDQAHNLIGPNIPAAVVDYNVGTQINLFGSYPTRADIAPSIVFAVIFGIIMLIHMAILIINTSRGHHFYLSYIWIVYSMMKVIGFALRAKWGTNQTLVAIGLTSEVFLIVPAVVIVSANLILAQRLFTWRHPVGGSRKLFWFFMISLYSFVTVLVAVTVLASFVPYLNFLSWWSYRSWIKAVQFTGVLVIVYSLTAVALIALSFWLPTKKDELRYTYQPWWIESFAPFYFVEKNAAQKAEASFMKRNSNHRHATRVIAATHHHFKSVKGLSNQRGDLKHNISMGLLIITTLLILIGDIGRCIVVFQARQSRHASQAANIWFMYVCWGIFEIIINALYIIGRVDLRFYRPDVLPAAVRSIVTAEQTYYPSSDEEEDGFHRDRPETYGKLRGRAEYGHATPNRHPAYGREDQESAFDDDEDDYFEDIDSQEWDFGGAKEKVSSSTEDTGQHPFGITQQDKKDEPPYPVYNSDKQHARFDDDNESEFNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0J0</accession>
    <accession>A0A1D8PGR4</accession>
    <name>U507_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>UPF0507 protein C2_02840C_A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAALFM_C202840CA</name>
        <name type="ORF">CaO19.13243</name>
        <name type="ORF">CaO19.5821</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715362.2">
        <property type="nucleotide sequence ID" value="XM_710269.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0J0"/>
    <dbReference type="SMR" id="Q5A0J0"/>
    <dbReference type="FunCoup" id="Q5A0J0">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0J0"/>
    <dbReference type="EnsemblFungi" id="C2_02840C_A-T">
        <property type="protein sequence ID" value="C2_02840C_A-T-p1"/>
        <property type="gene ID" value="C2_02840C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642976"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202840CA"/>
    <dbReference type="CGD" id="CAL0000186581">
        <property type="gene designation" value="orf19.13243"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02840C_A"/>
    <dbReference type="eggNOG" id="ENOG502R3ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008912_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A0J0"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="PRO" id="PR:Q5A0J0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000311651" description="UPF0507 protein C2_02840C_A">
        <location>
            <begin position="1"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="321"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1189" mass="139090" checksum="D00C6F38412B1D08" modified="2017-03-15" version="2">MTSTNKSISHLPILHNPFLNCLFNNPQYFKSPLKGVVDELQSNHTNFTILVPPAHVLNEYYDPTTESSNSKTLLKELCYNNEDFIRSHIINTASPVSSTITPISKEQSVIYNTLNNKQILIKNRIIYTGKGFRRSLKLKTLSIQYFSSFCDYFPKRSKFMIIYIESTLFGGIPPRKMLPPLPEVRETNKTDKDIDSVTFEKLLRSFPLLSKAVSDKFYRLFHHNNYQFRVLRYKNRKKLSHIKLEFQKILQEAFSIISDSVNVDNPNSEQTYNLINHIISMYPGIDLNKLVHEYVELNLYDVLWSQLIFQFNCPNDDKEAYDPEAILILTKEKYEKLSCLSLNQLDIPVNKPWLMNELHERISLGVQEFEKLADSSIMNSAAKTQVVYSTFRILTQRKNGNIDPVINADTLIGLLIMVMVHSKIENIEAHIYYIKHFNSIDNTNDGQFNYIMSNLDAVLFHFSKKESGYLDLIENSKKNYEIWNAIKNNDLEKVESIIELVNNEYPETELPENHFLKSKNINGESCLMFAIKTKRYEIYDCLINSNPNWIPIDSILFEKNVMTNQNLLMCALIEETDYKIIDDLVDIILNNATLEEQTMYFNMTDISGRSVGHYLFHNYKLISKIGHLIDWEKKDNNSHTPLFSLCRCYDHPEYVELIRAGFNCVYKKYGETGVDYDKHVDKSGNTLLHVLLKGIPESKMLSNSNNLVNVNQLNQRCLSPLMVYVKYNRLENLKEILHDSRLDFLGEDFKNYYNVFDYLSFSALKSTKSENFQNIENAVFNYYLQNYFPRHATENVAALNAKYDGGKKDWLIFFKNGDGFCNYKSLRNIKQILYLIKLKQPLSTFPSEESFWKNYGFGISTSPMFHKVRINRLIDDFNLLFEGLTFQESINQSEFFKTFLTEYTKETSIFESKQRIGEQLDFDKQSLGEVTYKLNQIQEIEYFLEYSLNNFQKYAYLFARLAKLVCIGDSKQVDCRNVLDTIMYRFNKTTVFDDIFTYSEVNNQAGTLGVAREYFYWIQMHGDELLHSIQKLVSDINSWKQMYYSICHINSELKLMEPHNTVSQESQDNSNGQELLSRRDSSLSINPIPEEELEDDNLGFLSNFVGTSKKARYKKLVVEKSEIVKNIMKLNLEIKWSHELIAAEISDFLKFRTEFLRFGIKRYISEEIKSLKQRSTELSKYVFLVRKDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A0J9</accession>
    <accession>A0A1D8PGR2</accession>
    <name>ETT1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Enhancer of translation termination 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ETT1</name>
        <name type="ordered locus">CAALFM_C202930CA</name>
        <name type="ORF">CaO19.13234</name>
        <name type="ORF">CaO19.5812</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct translation termination and probably involved in regulation of hypoxic gene expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ETT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715353.1">
        <property type="nucleotide sequence ID" value="XM_710260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A0J9"/>
    <dbReference type="SMR" id="Q5A0J9"/>
    <dbReference type="FunCoup" id="Q5A0J9">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A0J9"/>
    <dbReference type="EnsemblFungi" id="C2_02930C_A-T">
        <property type="protein sequence ID" value="C2_02930C_A-T-p1"/>
        <property type="gene ID" value="C2_02930C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3643015"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202930CA"/>
    <dbReference type="CGD" id="CAL0000200223">
        <property type="gene designation" value="orf19.13234"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02930C_A"/>
    <dbReference type="eggNOG" id="ENOG502QPHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050427_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A0J9"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="PRO" id="PR:Q5A0J9"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024318">
        <property type="entry name" value="Nro1/ETT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290:SF1">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12753">
        <property type="entry name" value="Nro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000406610" description="Enhancer of translation termination 1">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="421" mass="48230" checksum="3E3947A3029F2851" modified="2005-04-26" version="1">MAKRTLGLAKAAKAKKQKKEQEHQESSASPDEESSSSNQLTIELPEEIDANDEISQLKGLHKTYLQSERDNELLVNGIIHECDRLLRENDSENKQPLPAVFHAIYAIALAELSKFHTEELDKVKEFFIAALERVESGLEKNPNDINLLVAKTKILLDQISLQYIAPLTLESDVKELDKEIDELLDAALSVYESVEARAKELKDYSIFDDSETLDILEALDDILDIVDNFGKENQGDDGSDEDDEEDDDEEEKSVELAETHPLYKIKNSDKYDQWWRDHTHLYLDNLEKLENGSPELKREVCHRLGQSYLQESEVPYSVFTKLKYDDEYDGIEELEGLTEKEAQKISQELITKALDYLKQAKDEEDPETWVSIAEAMISLGNLYEVDSKEQEDLYLEAEKILKRANNVTNGKFQEELDNLLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1D5</accession>
    <accession>A0A1D8PML2</accession>
    <accession>Q9HF08</accession>
    <name>SPT16_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>FACT complex subunit SPT16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>CaCDC68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cell division control protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Facilitates chromatin transcription complex subunit SPT16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CDC68</name>
        <name type="synonym">SPT16</name>
        <name type="ordered locus">CAALFM_C406500WA</name>
        <name type="ORF">CaO19.10402</name>
        <name type="ORF">CaO19.2884</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Arch. Microbiol." volume="178" first="428" last="436">
            <title>Validation of Cdc68p as a novel antifungal target.</title>
            <authorList>
                <person name="Buurman E.T."/>
                <person name="Jiang W."/>
                <person name="McCoy M."/>
                <person name="Averett D.R."/>
                <person name="Thompson C.M."/>
                <person name="Wobbe C.R."/>
            </authorList>
            <dbReference type="PubMed" id="12420162"/>
            <dbReference type="DOI" id="10.1007/s00203-002-0470-y"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.</text>
    </comment>
    <dbReference type="EMBL" id="AF253047">
        <property type="protein sequence ID" value="AAG48574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715540.2">
        <property type="nucleotide sequence ID" value="XM_710447.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1D5"/>
    <dbReference type="SMR" id="Q5A1D5"/>
    <dbReference type="FunCoup" id="Q5A1D5">
        <property type="interactions" value="1440"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A1D5"/>
    <dbReference type="EnsemblFungi" id="C4_06500W_A-T">
        <property type="protein sequence ID" value="C4_06500W_A-T-p1"/>
        <property type="gene ID" value="C4_06500W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642787"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406500WA"/>
    <dbReference type="CGD" id="CAL0000198046">
        <property type="gene designation" value="CDC68"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06500W_A"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A1D5"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="PRO" id="PR:Q5A1D5"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140719">
        <property type="term" value="P:constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007063">
        <property type="term" value="P:regulation of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000245181" description="FACT complex subunit SPT16">
        <location>
            <begin position="1"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAG48574." evidence="4" ref="1">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAG48574." evidence="4" ref="1">
        <original>N</original>
        <variation>S</variation>
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAG48574." evidence="4" ref="1">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAG48574." evidence="4" ref="1">
        <original>A</original>
        <variation>G</variation>
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAG48574." evidence="4" ref="1">
        <original>S</original>
        <variation>SQS</variation>
        <location>
            <position position="734"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAG48574." evidence="4" ref="1">
        <location>
            <begin position="1030"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1060" mass="121334" checksum="9362119DC7CB3C0F" modified="2017-03-15" version="2">MSEVNIDAGLFYKRLSIFQKQLTANNIPQALIIVGARSDDNTYKKSTVLQNWLLGYEFIHTAIYITDKKCIFITSEGKSKHLKHLTNQKPDLVELWIRTKDVEHNKQLFIKLLETMTKLDSKYGKILKDKYDGKFIDEWNQILNDDNNNNNNNTTNDHALSAVDLAVTVSQALAVKDSEEFNNTKIASNASVVMMDTFVNDMMIIVDDEKKITNSQLTDQIEDKIENNKWYLKTKLGKNLLQSIKDFDPEYLEYCYSPIIQSGGDYDLKPSAVSTDKPLIGEGVILSSIGLRYKSYCSNIARTFLIDPTSEMETNYDFLLQLQKYIVDNLLKDGVPANKVYQDTIDYIKKERPDLVNHFTKNCGWLLGMEFRDSTFILNAKTTDRKLTTGQIISLTIGFNNLSNDKNDKNDKNDNKTNHQKNKQTYALLLTDTIKITDDSSILLTNYSKDRAAISFSFNDDNETQKENNNNNNKRPGLSQTSNTTALKLESTENTAILKSKLRHENTNADDANSEKLRQEIQIKLHEKRLQEGLARFSKADATDADDFKPIFKKYESYVRESQIPNSVNDLKIHIDYKNQTIILPISGRPVPFHINSYKSGSQNEEGDFTYLRLNFNSPGAGGNVTKKQELPYEDSPDNSFLRSITIRSRDRQRMVDVYKAIQDLKKDSVKREQEKKQMADVITQANLIELKGSRVKKLNNVFIRPTPDTKKIGGVLQIHENGLRYQSQPQSQSNFKNDQRVDVLFSNIKHLFFQPCKDELIVLIHCHLKNPIMIGKRKTFDVQFYREASDMAFDETGGRKRKYRYGDEDELQQEQEERRRKALLDKEFKGFAELIADSSHGMVDLDIPFRELGFQGVPFRSSVLCVPTRDCLVQLIDPPYLVVTLEEIEIAHLERVQFGLKNFDLVFVFKDFNKPVVHINTIPVELLEDVKSWLTDVDIPISEGQMNLNWVQIMKTVLADPYQFFIDGGWAFLTGQGESDEEEESDEESDFRVSDEDPQDEDEESDDYASEEESDDYSGSDDDGSGGGGDDDDDDSESGEDWDALERKAAKADRNSGFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A1E1</accession>
    <accession>A0A1D8PMM5</accession>
    <name>PGA15_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Probable cell wall protein PGA15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Predicted GPI-anchored protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PGA15</name>
        <name type="ordered locus">CAALFM_C406560WA</name>
        <name type="ORF">CaO19.10396</name>
        <name type="ORF">CaO19.2878</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Yeast" volume="24" first="357" last="370">
            <title>Global transcriptional profiling of Candida albicans cwt1 null mutant.</title>
            <authorList>
                <person name="Moreno I."/>
                <person name="Castillo L."/>
                <person name="Sentandreu R."/>
                <person name="Valentin E."/>
            </authorList>
            <dbReference type="PubMed" id="17238235"/>
            <dbReference type="DOI" id="10.1002/yea.1444"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Yeast" volume="20" first="781" last="796">
            <title>Genome-wide identification of fungal GPI proteins.</title>
            <authorList>
                <person name="De Groot P.W."/>
                <person name="Hellingwerf K.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="12845604"/>
            <dbReference type="DOI" id="10.1002/yea.1007"/>
        </citation>
        <scope>PREDICTION OF GPI-ANCHOR</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Antimicrob. Agents Chemother." volume="57" first="873" last="886">
            <title>Milbemycins: more than efflux inhibitors for fungal pathogens.</title>
            <authorList>
                <person name="Silva L.V."/>
                <person name="Sanguinetti M."/>
                <person name="Vandeputte P."/>
                <person name="Torelli R."/>
                <person name="Rochat B."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="23208712"/>
            <dbReference type="DOI" id="10.1128/AAC.02040-12"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <topology evidence="5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4">Up-regulated upon milbemycin A3 oxim derivative (A3Ox) treatment. Expression is also regulated by CWT1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715534.1">
        <property type="nucleotide sequence ID" value="XM_710441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A1E1"/>
    <dbReference type="STRING" id="237561.Q5A1E1"/>
    <dbReference type="EnsemblFungi" id="C4_06560W_A-T">
        <property type="protein sequence ID" value="C4_06560W_A-T-p1"/>
        <property type="gene ID" value="C4_06560W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3642781"/>
    <dbReference type="KEGG" id="cal:CAALFM_C406560WA"/>
    <dbReference type="CGD" id="CAL0000184232">
        <property type="gene designation" value="PGA15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_06560W_A"/>
    <dbReference type="HOGENOM" id="CLU_141124_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A1E1"/>
    <dbReference type="OMA" id="DQEDACG"/>
    <dbReference type="OrthoDB" id="4025955at2759"/>
    <dbReference type="PRO" id="PR:Q5A1E1"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424737" description="Probable cell wall protein PGA15">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424738" description="Removed in mature form" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17238235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23208712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="165" mass="18105" checksum="CD05FB659C2018DF" modified="2005-04-26" version="1" precursor="true">MKFIIILFTLISIVTAAQRIYNKDYSYYGCNSYCDKASDQEDACGYYDDDVSYQDYYGCLCGNEIFLSNLKSCDCFTSIIASVSKSVCSKATEDSDWGYYDDSTSSIMDFFTADNTPASNTGMTTQTDGAINDNQNTGSKTSSGAANYLTSFSIGTFFVFVLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3J9</accession>
    <name>Q5A3J9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C111940CA</name>
        <name evidence="4" type="ordered locus">orf19.12736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW26814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716340.1">
        <property type="nucleotide sequence ID" value="XM_711247.1"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="L domain-like"/>
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        <location>
            <begin position="1"/>
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            <begin position="184"/>
            <end position="203"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <accession>Q5A4M8</accession>
    <accession>A0A1D8PPP2</accession>
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        <recommendedName>
            <fullName>Protein SUR7</fullName>
        </recommendedName>
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        <name type="primary">SUR7</name>
        <name type="ordered locus">CAALFM_C601720CA</name>
        <name type="ORF">CaO19.10917</name>
        <name type="ORF">CaO19.3414</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Proteomics" volume="9" first="4770" last="4786">
            <title>Analysis of Candida albicans plasma membrane proteome.</title>
            <authorList>
                <person name="Cabezon V."/>
                <person name="Llama-Palacios A."/>
                <person name="Nombela C."/>
                <person name="Monteoliva L."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="19824013"/>
            <dbReference type="DOI" id="10.1002/pmic.200800988"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="Mol. Biol. Cell" volume="19" first="5214" last="5225">
            <title>The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans.</title>
            <authorList>
                <person name="Alvarez F.J."/>
                <person name="Douglas L.M."/>
                <person name="Rosebrock A."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="18799621"/>
            <dbReference type="DOI" id="10.1091/mbc.E08-05-0479"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="BMC Microbiol." volume="10" first="133" last="133">
            <title>Candida albicans SUR7 contributes to secretion, biofilm formation, and macrophage killing.</title>
            <authorList>
                <person name="Bernardo S.M."/>
                <person name="Lee S.A."/>
            </authorList>
            <dbReference type="PubMed" id="20433738"/>
            <dbReference type="DOI" id="10.1186/1471-2180-10-133"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="72" last="80">
            <title>The Candida albicans Sur7 protein is needed for proper synthesis of the fibrillar component of the cell wall that confers strength.</title>
            <authorList>
                <person name="Wang H.X."/>
                <person name="Douglas L.M."/>
                <person name="Aimanianda V."/>
                <person name="Latge J.P."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="21115741"/>
            <dbReference type="DOI" id="10.1128/EC.00167-10"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="Eukaryot. Cell" volume="10" first="1071" last="1081">
            <title>Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.</title>
            <authorList>
                <person name="Sorgo A.G."/>
                <person name="Heilmann C.J."/>
                <person name="Dekker H.L."/>
                <person name="Bekker M."/>
                <person name="Brul S."/>
                <person name="de Koster C.G."/>
                <person name="de Koning L.J."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="21622905"/>
            <dbReference type="DOI" id="10.1128/EC.05011-11"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="Cell. Microbiol." volume="15" first="1572" last="1584">
            <title>Cell surface changes in the Candida albicans mitochondrial mutant goa1Delta are associated with reduced recognition by innate immune cells.</title>
            <authorList>
                <person name="She X."/>
                <person name="Zhang L."/>
                <person name="Chen H."/>
                <person name="Calderone R."/>
                <person name="Li D."/>
            </authorList>
            <dbReference type="PubMed" id="23490206"/>
            <dbReference type="DOI" id="10.1111/cmi.12135"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2012" name="MBio" volume="3" first="135" last="150">
            <title>Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans.</title>
            <authorList>
                <person name="Douglas L.M."/>
                <person name="Wang H.X."/>
                <person name="Keppler-Ross S."/>
                <person name="Dean N."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="22202230"/>
            <dbReference type="DOI" id="10.1128/mBio.00254-11"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5 6 8">Involved in cell wall, plasma membrane, and cytoskeletal organization. Plays a role in endocytosis and hyphal morphogenesis. Required to restrict septin proteins to the bud neck and prevents intracellular growth of cell wall. Contributes to secretion, biofilm formation, and macrophage killing. Essential for resistance to stressful conditions and for invasive growth and virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4 6">Cell membrane</location>
            <topology evidence="3 4 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text>Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.</text>
    </comment>
    <comment type="induction">
        <text evidence="7 9">Induced by fluconazole and down-regulated in absence of GOA1.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Leads to defective tolerance to cell wall stress and antifungal agents targeting cell wall components, defective plasma membrane structure, defective endocytosis, impaired lipase secretion, SAP2 over-production, increased adherence, aberrant biofilm formation, defective macrophage killing, and decreased virulence in a mouse infection model.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SUR7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="C6_01720C_A"/>
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    <dbReference type="GeneID" id="3641610"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601720CA"/>
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        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
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        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000255"/>
        <property type="project" value="CGD"/>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    <accession>Q5A744</accession>
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        <recommendedName>
            <fullName>Protein SDS23</fullName>
        </recommendedName>
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    <gene>
        <name type="primary">SDS24</name>
        <name type="synonym">SDS23</name>
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        <name type="ORF">Ca41C10.01c</name>
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        <name type="ORF">CaO19.5118</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>Candida albicans strain 1161 genome pilot sequencing project.</title>
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>1161</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="J. Antimicrob. Chemother." volume="55" first="645" last="654">
            <title>Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.</title>
            <authorList>
                <person name="Copping V.M.S."/>
                <person name="Barelle C.J."/>
                <person name="Hube B."/>
                <person name="Gow N.A.R."/>
                <person name="Brown A.J.P."/>
                <person name="Odds F.C."/>
            </authorList>
            <dbReference type="PubMed" id="15820985"/>
            <dbReference type="DOI" id="10.1093/jac/dki088"/>
        </citation>
        <scope>INDUCTION BY FLUCONAZOLE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="induction">
        <text evidence="4">By the antifungal drug fluconazole.</text>
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    <comment type="similarity">
        <text evidence="5">Belongs to the SDS23 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
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    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CBS_dom"/>
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        <property type="entry name" value="CBS_dom_sf"/>
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    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0129">CBS domain</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000324949" description="Protein SDS23">
        <location>
            <begin position="1"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="CBS 1" evidence="2">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CBS 2" evidence="2">
        <location>
            <begin position="334"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21985." evidence="5" ref="1">
        <original>N</original>
        <variation>Y</variation>
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA21985." evidence="5" ref="1">
        <original>A</original>
        <variation>AA</variation>
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15820985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="628" mass="67545" checksum="4ABA432FC1661628" modified="2017-04-12" version="2">MVNPPQPRQMPKSPRLSTSTSSGPSAVPNLLGSPRPSPPQLQHQPSSASTSSTTSTATTGGSISATAPGSTQHYLHHHPSRKTSIVEILSSPPPLPTDPNDPIHQLSLSRHASTSSNKSSSQSIAPGSTAITNHAFSLVDWSEIPLTELTESNKLISIHSSHSVQSAFETLLKNNLTSVPVSISKSDPHDLTNCLTFDYSDLNTYLLLIMNKINYSELNVDDIGDPNISPQERHEFVTQTISKAKRGEEVPVEFIIKLHPKNPFIKFNETDTLFSVMETLGNGVHRIAITNEEGNKITGILSQRRLIKYMWENARRFPSLDFYLTSTLQDLKIGSSNPITIYEDQMLIEALHKMFNERVSSLAVIDRSRTLIGNISIVDVKNVTSSKNSHLLFKSVLNFISYNLSQKGIEEGQDQFPIFHVNNQTSLGRVIAKLVATQSHRLWIVDSSRQASSMSSASASAPNSGMNNGVTVGYPAPADSSITDKAEEVEASSMSSPQLNAAAAAAAAVATGAPTTATSAQPDFSYTSGTGKLVGVVTLTDILGLFATSKGRRTDPQAARNQRRRSSTSTTRSSIDSALSAEGILPSGSAIIGSSNAANTGRRGSVEVSSDVFRKSYTKAQENAFSKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7K0</accession>
    <name>RS24_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS24</name>
        <name type="ordered locus">orf19.5466</name>
        <name type="ORF">CAALFM_C300090WA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717837.1">
        <property type="nucleotide sequence ID" value="XM_712744.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="Z=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Z=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="Z=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="Z=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="Z=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="DL/a=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
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    <dbReference type="PDB" id="8OH6">
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        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="DL/a=1-135"/>
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    <dbReference type="PDB" id="8OI5">
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        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="DL/a=1-135"/>
    </dbReference>
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        <property type="resolution" value="3.50 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="Z=1-135"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
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    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="Q5A7K0"/>
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    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="Q5A7K0"/>
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5A7K0"/>
    <dbReference type="EnsemblFungi" id="C3_00090W_A-T">
        <property type="protein sequence ID" value="C3_00090W_A-T-p1"/>
        <property type="gene ID" value="C3_00090W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640568"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300090WA"/>
    <dbReference type="CGD" id="CAL0000180342">
        <property type="gene designation" value="RPS24"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00090W_A"/>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="InParanoid" id="Q5A7K0"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456561" description="Small ribosomal subunit protein eS24">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="135" mass="15513" checksum="9F0A6D5A84FEB3FF" modified="2005-04-26" version="1">MSDAVTIRTRKVISNPLLARRQFVIDVLHPNRANVSKDELREKLAEIYKAEKDAVSVFGFRTQFGGGKSTGFGLIYQSVADAKRFEPAYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTQRRAQKRAARRNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7K1</accession>
    <name>Q5A7K1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C300100WA</name>
        <name evidence="10" type="ordered locus">orf19.12920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717836.1">
        <property type="nucleotide sequence ID" value="XM_712743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7K1"/>
    <dbReference type="SMR" id="Q5A7K1"/>
    <dbReference type="FunCoup" id="Q5A7K1">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A7K1"/>
    <dbReference type="GeneID" id="3640567"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300100WA"/>
    <dbReference type="CGD" id="CAL0000187554">
        <property type="gene designation" value="orf19.12920"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00100W_A"/>
    <dbReference type="HOGENOM" id="CLU_053603_2_0_1"/>
    <dbReference type="InParanoid" id="Q5A7K1"/>
    <dbReference type="OMA" id="CDEYIGA"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000384">
        <property type="term" value="F:first spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000187554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW28060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="232" mass="27261" checksum="E5F714F7C128C13F" modified="2005-04-26" version="1">MSERKAINKWYPPDYDPSKIPRPKKNANQPIKIRMMAPYSMRCLKCDEYIGARRSFNARKEITNEKYLNIKIIRFYITCPGCNNTITFKTDPKNAGYTPEEGAVRNYEKAKPTETEDDILARLQKEEEEDQKYHLLQAKRKKNPFWNEQTSGMENLEQRLKEQHHHQKLDQQLEAIQARAVNKDLLESKARENLQQSTKPVAKRKLVIPTTIKLPKKPRLARPNPETQNRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A7Q9</accession>
    <name>Q5A7Q9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">rRNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">SOF1</name>
        <name evidence="10" type="ordered locus">CAALFM_C300560CA</name>
        <name evidence="9" type="ordered locus">orf19.12862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717779.1">
        <property type="nucleotide sequence ID" value="XM_712686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A7Q9"/>
    <dbReference type="SMR" id="Q5A7Q9"/>
    <dbReference type="FunCoup" id="Q5A7Q9">
        <property type="interactions" value="1336"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A7Q9"/>
    <dbReference type="GeneID" id="3640585"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300560CA"/>
    <dbReference type="CGD" id="CAL0000196031">
        <property type="gene designation" value="SOF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00560C_A"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A7Q9"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001105">
        <property type="entry name" value="WD40-repeat-containing domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="8">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000196031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="436" mass="49421" checksum="F84386986A36F0D1" modified="2005-04-26" version="1">MKVKTISRSSDTYIPVKNTQESALPRNLNPALHPFERAREYTRALQATKLERMFAQPFIGQLGDGHRDGVYFIAKNYQATNQIASGSGDGIIKYWNLTDRLETASFKAHYGMVSGICIYANKMYSCGDDKTIKIWSVNSDDFDIKVNDDVDGIYRNQLGGAGGGDGKTSGGLLKTFIGEHSFKGIDHHRDDDLFVTGGATIQLWDVNRSKHISDLSWGADNVGTVKFNQTETNIIASSGSDNSIVLYDIRTNTPVHKVVTSLRNNCITWNPMEAFNFATGNEDHNGYLYDMRNLQKTLKVYKGHVGAIMDVDFAPTGQELVTGSYDKTIRLWKTLDGRSKDVYHTKRMQKVFSVKYSTDSKYIISGSDDTNLRVWRSDASSRSNIKSSRQRAKLEYQDKLKERYKYMPEINRIARHRHLPKPVKKAQDMKRLYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8Z9</accession>
    <name>Q5A8Z9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial outer membrane protein OM14 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAALFM_C101490WA</name>
        <name evidence="4" type="ordered locus">orf19.10846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718158.1">
        <property type="nucleotide sequence ID" value="XM_713065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8Z9"/>
    <dbReference type="SMR" id="Q5A8Z9"/>
    <dbReference type="STRING" id="237561.Q5A8Z9"/>
    <dbReference type="GeneID" id="3640226"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101490WA"/>
    <dbReference type="CGD" id="CAL0000177503">
        <property type="gene designation" value="orf19.10846"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01490W_A"/>
    <dbReference type="eggNOG" id="ENOG502S89U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366067_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A8Z9"/>
    <dbReference type="OMA" id="YTERHRI"/>
    <dbReference type="OrthoDB" id="3980970at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039454">
        <property type="entry name" value="OM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039453">
        <property type="entry name" value="OM14_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402:SF1">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17304">
        <property type="entry name" value="OM14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane protein OM14 C-terminal" evidence="3">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000177503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW25840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="200" mass="21856" checksum="4068BE8248BDE9E2" modified="2005-04-26" version="1">MSSKAPSNEQIKKDVKKDADNIAKKGKEESEHLKKQGKEAVDEASEKGKEFIDQANKKGKELLDEANDKSKEFLKEARKELNHLEEEGQNLLSQFVAYVKSTANSIGQSLNKAGAELQSATSAAVSRTSVELQNPVVIAQIAVAAGGAAAGYLAYLERYRINTDNKYVVGIHASIITGLVVLDGYLFSTYYPKYDKKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A951</accession>
    <name>Q5A951_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">MDL1</name>
        <name evidence="13" type="ordered locus">CAALFM_CR02150WA</name>
        <name evidence="12" type="ordered locus">orf19.10146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718280.1">
        <property type="nucleotide sequence ID" value="XM_713187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A951"/>
    <dbReference type="SMR" id="Q5A951"/>
    <dbReference type="FunCoup" id="Q5A951">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A951"/>
    <dbReference type="GeneID" id="3640146"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR02150WA"/>
    <dbReference type="CGD" id="CAL0000191535">
        <property type="gene designation" value="MDL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_02150W_A"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="InParanoid" id="Q5A951"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001371">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="98"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="440"/>
            <end position="680"/>
        </location>
    </feature>
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        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000191535"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW30965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="685" mass="75960" checksum="A96C34AC91939BEC" modified="2005-04-26" version="1">MIGMNRLIFSKAFTSSCKSMGKVPFTKSITRANTRYFKPTSILQQIRFNSKSSTTPNTEANSNGSTNSQSDTKKPRPKLTSEIFKLLRLAKPESKLIFFALICLVTTSATTMTLPLMIGKIIDTTKKDDDDDKGKDNDDKDDTQPSDKLIFGLPQPQFYSALGVLFIVSASTNFGRIYLLRSVGERLVARLRSRLFSKILAQDAYFFDLGPSKTGMKTGDLISRIASDTQIISKSLSMNISDGIRAIISGCVGLSMMCYVSWKLSLCMSLIFPPLITMSWFYGRKIKALSKLIQENIGDMTKVTEEKLNGVKVIQTFSQQQSVVHSYNQEIKNIFNSSMREAKLAGFFYSTNGFIGNVTMIGLLIMGTKLIGAGELTVGDLSSFMMYAVYTGTSVFGLGNFYTELMKGIGAAERVFELVEYQPRISNHLGKKVDELNGDIEFKGIDFTYPSRPESGIFKDLNLHIKQGENVCLVGPSGSGKSTVSQLLLRFYDPEKGTIQIGDDVITDLNLNHYRSKLGYVQQEPLLFSGTIKENILFGKEDATDEEINNALNLSYASNFVRHLPDGLDTKIGASNSTQLSGGQKQRVSLARTLIRDPKILILDEATSALDSVSEEIVMSNLIQLNKNRGVTLISIAHRLSTIKNSDRIIVFNQDGQIVEDGKFNELHNDPNSQFNKLLKSHSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AAW4</accession>
    <name>Q5AAW4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RTT102</name>
        <name evidence="3" type="ordered locus">CAALFM_C107080WA</name>
        <name evidence="2" type="ordered locus">orf19.13576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718787.1">
        <property type="nucleotide sequence ID" value="XM_713694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AAW4"/>
    <dbReference type="STRING" id="237561.Q5AAW4"/>
    <dbReference type="GeneID" id="3639489"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107080WA"/>
    <dbReference type="CGD" id="CAL0000176156">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07080W_A"/>
    <dbReference type="eggNOG" id="ENOG502RQCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123970_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AAW4"/>
    <dbReference type="OMA" id="DLTEAKW"/>
    <dbReference type="OrthoDB" id="4008139at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000176156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="188" mass="21588" checksum="BDF1D6B4625BCFD0" modified="2005-04-26" version="1">MFSHSGTQTPVSASYQQQSQPHQLQNKVQFHEQLDETITWINDWYSPNLINNNTIRDANYNKSGQFVHYSVDTNKGHQGHSNRVSTINNFEEENSTPAVNDSIRLKGWHRTNLNHKHGESNEHYNNLNPSDVLDLNKWRYFNEVNQNENNTTMTTNKDAGVSSAAVKQEDPVSKDSAVERFSDTIKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABA1</accession>
    <name>Q5ABA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">ENA2</name>
        <name evidence="26" type="ordered locus">CAALFM_C100390WA</name>
        <name evidence="25" type="ordered locus">orf19.13491</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719032.1">
        <property type="nucleotide sequence ID" value="XM_713939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABA1"/>
    <dbReference type="SMR" id="Q5ABA1"/>
    <dbReference type="FunCoup" id="Q5ABA1">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ABA1"/>
    <dbReference type="GeneID" id="3639291"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100390WA"/>
    <dbReference type="CGD" id="CAL0000188030">
        <property type="gene designation" value="ENA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00390W_A"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="InParanoid" id="Q5ABA1"/>
    <dbReference type="OMA" id="NGQEYSM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000040">
        <property type="entry name" value="Na(+)-exporting P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="CGD" id="CAL0000188030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="AOW25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117132" checksum="CF95FE6EFC87AC22" modified="2005-04-26" version="1">MSSTKENSNYASGDTKERANSDLSESDRSTPPRDPNSTFQAYRLTIDEVAQEFNTSIVDGLGAHDAENRIQAYGPNNLGEGDKISYPKILAHQVFNAMILVLIISMIIALAIKDWISGGVIAFVVFLNISVGFVQEVKAEKTMGSLKNLSSPTARVTRNGDDFTIPAEEVVPGDIVHIKVGDTVPADLRLFDCMNLETDEALLTGESLPVAKNFEVVYTDYSVPVPVGDRLNLVYSSSIVSKGRGSGIVFATGLNTEIGAIAQSLKGNSGLIRRVDKSNDRKPQKREYGQAAAGTIYDVVGNILGVTVGTPLQRKLSWLAIFLFCVAVVFAIIVMGSQKFHVNKEVAIYAICVALSMIPSALILVLTITMAVGAQVMVTKNVIVRKFDSLEALGGINDICSDKTGTLTQGKMIAKKVWLPNIGTLDVQNSNEPYNPTVGDVRFAPYSPKFVKETDEEIDFNKPYPDPMPESMHKWLMTATLANIATVNQTKDEDTGELLWKAHGDATEIAIQVFTTRLNYGRESIAQEYEHLAEFPFDSSIKRMSAIYKKDGETRVYTKGAVERLLGLCDYWYGERTEDDYDSQTLVKLTEDDAKLIEENMAALSSQGLRVLAFATKELGDADMNDREQVESHLIFQGLIGIYDPPREESAQSVKSCHKAGINVHMLTGDHPGTAKAIAQEVGILPHNLYHYSEDVVKVMVMSANDFDALTDDEIDNLPVLPLVIARCAPKTKVRMIDALHRRKKFAAMTGDGVNDSPSLKKADVGIAMGLNGSDVAKDASDIVLTDDNFASILNAIEEGRRMSANIQKFVLQLLAENVAQAFYLMIGLAFLDETGYSVFPLSPVEVLWILVVTSTFPAIGLAQNAASDDILEKPPNNTIFTWEVIIDMFAYGVIMAATCLLSFVIVVYGAGNGDLGIDCNATNADKDLCSLVFEGRSTAFASMTWQALILAWECLDPKKSLLLIPFSELWANQFLFWSIVGGFVTVFPVIYIPVINTKVFLHKSITWEWGVAVGTTALFLLGAEAWKWGKRVFARSSKAKNPEYELERNDPFQRYASFSRANTMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADV2</accession>
    <name>Q5ADV2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphoribomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAALFM_C307490WA</name>
        <name evidence="14" type="ordered locus">orf19.14031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719837.1">
        <property type="nucleotide sequence ID" value="XM_714744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADV2"/>
    <dbReference type="SMR" id="Q5ADV2"/>
    <dbReference type="FunCoup" id="Q5ADV2">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADV2"/>
    <dbReference type="GeneID" id="3638528"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307490WA"/>
    <dbReference type="CGD" id="CAL0000187913">
        <property type="gene designation" value="orf19.14031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07490W_A"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ADV2"/>
    <dbReference type="OMA" id="GYCVDPE"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="entry name" value="Pgm3p"/>
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    </dbReference>
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        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
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        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="48"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="146"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="239"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="351"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000187913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="616" mass="69343" checksum="80825BD648D9750D" modified="2005-04-26" version="1">MTVDKNKLDELVKSWLSIDMNPESRHEIEQLHISGNYEQLDRKLSKRIAFGTAGLRSSMESGFSHMNDVTVLQASQGLVKYLLKKTPTSIVIGYDHRFNSQRFAEILASVALTQGVHVYYLGSVANLSEETMKLTKGDIENDSSTDRGYVHTPLVPFAIDYYGASGGVMITASHNPANDNGYKVYYSNGCQIIPPVDKEIADSIEENLTPWEGVWDVYDNIKKGVQKGLLSLAGDEVTKEYLKGVKEKLIQDNNLDFSFVYTPMHGVGYRIFKECLDLFHASTWNVVQEQADPDPTFRTVSFPNPEEKGALDLAIETARKLGYKLVLANDPDADRFSVAVETKGQWNQLTGNEIGFLFAMYVIEQQKEQDLDRVYLVNSTVSSQILKAMADKDGFHFQDTLTGFKWIGNKAIDLQKEGFKVPFGYEEAIGFMFDLVHDKDGISAATIFLQLYQKWFSGGKIDVTDKLEAGYAKYGWFKDYNGYYRLADMSTLDKIFTNIRGSFDSKSPENIGEFKVTSWRDLTIGYDSSTVDHTPVLPVDSSSQMITASLKLPGNDNAVVRFTCRGSGTEPKLKLYIEGKSTINEQSAKEIAVKCWETLKQEWFQPEKYNLTEVKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEI2</accession>
    <accession>A0A1D8PJJ0</accession>
    <name>ATG10_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Ubiquitin-like-conjugating enzyme ATG10</fullName>
            <ecNumber>2.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG10</name>
        <name type="ordered locus">CAALFM_C302930WA</name>
        <name type="ORF">CaO19.286</name>
        <name type="ORF">CaO19.7918</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Antimicrob. Agents Chemother." volume="48" first="3064" last="3079">
            <title>Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.</title>
            <authorList>
                <person name="Karababa M."/>
                <person name="Coste A.T."/>
                <person name="Rognon B."/>
                <person name="Bille J."/>
                <person name="Sanglard D."/>
            </authorList>
            <dbReference type="PubMed" id="15273122"/>
            <dbReference type="DOI" id="10.1128/AAC.48.8.3064-3079.2004"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is decreased upon fluphenazine treatment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.-"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719983.1">
        <property type="nucleotide sequence ID" value="XM_714890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEI2"/>
    <dbReference type="SMR" id="Q5AEI2"/>
    <dbReference type="EnsemblFungi" id="C3_02930W_A-T">
        <property type="protein sequence ID" value="C3_02930W_A-T-p1"/>
        <property type="gene ID" value="C3_02930W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638380"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302930WA"/>
    <dbReference type="CGD" id="CAL0000193637">
        <property type="gene designation" value="orf19.7918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02930W_A"/>
    <dbReference type="eggNOG" id="ENOG502T5Z6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096164_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AEI2"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="PRO" id="PR:Q5AEI2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000096186" description="Ubiquitin-like-conjugating enzyme ATG10">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15273122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="177" mass="20668" checksum="12EE99E1A5A5A072" modified="2005-04-26" version="1">MITNQQFNDNIEEFISIMLANLKLKGTDFEFSVNNNYVNKWNIDKMYSFVSVSVKQLRIDFTISFDDLYGVPLLNMRLYDNDTFLTSPMAQRTLAVGICRVDLHNHHLLQQPWLQVHPCETLQTIDSHLKNTPTCKYNSVIQYLCCWFGLYGLPSIFPQFSVRPNIYINNVQSCKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AFD1</accession>
    <name>Q5AFD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C403140CA</name>
        <name evidence="9" type="ordered locus">orf19.10191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720429.1">
        <property type="nucleotide sequence ID" value="XM_715336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AFD1"/>
    <dbReference type="SMR" id="Q5AFD1"/>
    <dbReference type="FunCoup" id="Q5AFD1">
        <property type="interactions" value="1195"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AFD1"/>
    <dbReference type="GeneID" id="3637843"/>
    <dbReference type="KEGG" id="cal:CAALFM_C403140CA"/>
    <dbReference type="CGD" id="CAL0000180661">
        <property type="gene designation" value="orf19.10191"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_03140C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050414_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AFD1"/>
    <dbReference type="OMA" id="WEPESTF"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000180661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW29077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="298" mass="34080" checksum="98DA2FA9316695DA" modified="2005-04-26" version="1">MSSTSQNATVLLTRLLSLKENSSFHLILDSLTQSSYYLIQEYIHRCSKTTSKIIYLSFETINKPHYCSEFIDCSDITLHQIVEKVNPLRESNERSLILIDSLNYINNDELAHFVAQLVGPEITLVGVYHTQCPVAASKYPNYPSSETLLSYIASTIFELYPLIPDSLDEEELDAKVKKLTFPINSNLNSAIFKVILTNRRKSGRSLTYTLIINSLNHEYEIWKDKQESDEILQEDESLLKDLTTFNLTTSSKQKLAREQVELPFMQAQESLGAAGGAIVYEFEKDDDYDEEDPYEDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AGX1</accession>
    <accession>Q3MPI2</accession>
    <name>Q5AGX1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">SMC6</name>
        <name evidence="16" type="ordered locus">CAALFM_C701580WA</name>
        <name evidence="15" type="ordered locus">orf19.13921</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721404.1">
        <property type="nucleotide sequence ID" value="XM_716311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AGX1"/>
    <dbReference type="SMR" id="Q5AGX1"/>
    <dbReference type="FunCoup" id="Q5AGX1">
        <property type="interactions" value="856"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AGX1"/>
    <dbReference type="GeneID" id="3637039"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701580WA"/>
    <dbReference type="CGD" id="CAL0000185544">
        <property type="gene designation" value="SMC6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01580W_A"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AGX1"/>
    <dbReference type="OMA" id="MCHDHFY"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="14">
        <location>
            <begin position="108"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="314"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="713"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="943"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000185544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW30524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1128" mass="129807" checksum="4C06E15B1E056691" modified="2005-04-26" version="1">MTVPYKRKHDADSLFDARNGGEGVSEYMSQLLINSSDQPRKRRTMTQAPSRNGRESASETESISGADSDSDGESDDDEDDEDDDDDDEEEDDDDDVGSDPAKAGVIEKLTLKNFMCHDSFELKLGPQLNFIIGRNGSGKSAILTGISVGLGAKATDTNRGSTIRDLIKDGKSTSRITVVLKNEGSDAYKPDVFGKKIIIERKLQRSGSNTYSIKNEAGKVVSNKKSVLDEILYKFSITIDNPLAFLSQDKAREFLTSSSDKNKYEYFMDGAFITDILENYTSISNNVQVLDNKVRQAEEYTKVAKQEYKAIAKVHNAHRTNDALRNKLEMLNAKIYWFNVQTIEKKIDQENRQKDTCLQEIEQAKNQIDVCEKEIEAKIPRKDAADQQVKEVESQIKDIVEEFEGLRSKRSEMKSELEINKKETKKNIDEMNSLKEDITRTETKIEQERRRIQELQGGNKEKMAEELEKLNSEIDELESQLENLKKQLVEMQDNPDPELRSVSQQREKSRQKIADLQNQKRQLEKESVSKYSPWGSRMAELIKAIKRHPDWVQEPIGPIGSYIHVKNQYNNWKPLLSTILNKTLDSFIVTNEGDRSRLDRLLKQYQIRSNIIVKKTERLNYASGKADSAFTTVLDMLNVENDTILYALIDINSIEKNVIVESASEARDSCRRRNVQNSLVLFRKDSGHRMSYQNNTFRQDPIYYQNGMAKFGVANMSDLISDLQRELDEEHRHQNDLERRARSIKMKLDAKRDNLVSESRAIKRNLDQLKRNRSTLEDQLEVEVDYSNITTLEARIEDNNEQIRRLVALNEALLENLSQMNENYKDLKQQIEDCKSKKVKHETIREKFVKQLVEIETEIETQEDLKKRYLYKITELEDRIKRADDILAEGNRKLEEFVAKAEEHCSRDRVTIYPNDTQETIAQDYQETRFDLERAESALGTSLEEVLDQLEKAKAKCDKAEGELESLSSASRKLNAEVNARFNFLHTIIQSSIQEAKRTFEKAMWLRGFQGTLKFDFAEKTLQLNVQTGNDEKKRTVESLSGGEKSFSQIALLLSIWKVMNSRIRGLDEFDVYMDSVNRSISIKLLLKELKRYPKSQNIFITPQDIAVVGELNDKGVKIHKMSAPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALJ2</accession>
    <name>Q5ALJ2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fgr22p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">FGR22</name>
        <name evidence="3" type="ordered locus">CAALFM_C202600CA</name>
        <name evidence="2" type="ordered locus">orf19.9159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722628.1">
        <property type="nucleotide sequence ID" value="XM_717535.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALJ2"/>
    <dbReference type="SMR" id="Q5ALJ2"/>
    <dbReference type="STRING" id="237561.Q5ALJ2"/>
    <dbReference type="PeptideAtlas" id="Q5ALJ2"/>
    <dbReference type="GeneID" id="3635862"/>
    <dbReference type="KEGG" id="cal:CAALFM_C202600CA"/>
    <dbReference type="CGD" id="CAL0000195513">
        <property type="gene designation" value="FGR22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_02600C_A"/>
    <dbReference type="HOGENOM" id="CLU_024117_3_1_1"/>
    <dbReference type="InParanoid" id="Q5ALJ2"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000074">
        <property type="entry name" value="Phosphatidylinositol-specific phospholipase c, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000195513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="295" mass="33586" checksum="E273658935E55859" modified="2005-04-26" version="1">MVDYKTWLKDIDNNTRISKLSIPGTHNSAACHTALPSVQCQGASVTEQLEHGVRFLDIRVGKLFVGNDVKDLQVIHGKFPVKIPFPLKLNDSLEEVYKFLAHNSSETVIVSIKQEGSDDWDNSQDEFGKLIWDRYVNPNKDRWYLNTDIPKLGDARGKAILFRRFGVQDEQLKKQFGFSASSWAYNTTNDDRGQFVVQDFCEVNTADDLPKKIDYVKDLAKRAQDYTSKGDDKVFLNFTSASNFFDQSCWPQPIAEAMIKGNIQETFHKGVGIIVLDYAETDNWKLPEALIDTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AMP3</accession>
    <name>Q5AMP3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Arf family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">ARL1</name>
        <name evidence="15" type="ordered locus">CAALFM_C401890CA</name>
        <name evidence="14" type="ordered locus">orf19.12073</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722675.1">
        <property type="nucleotide sequence ID" value="XM_717582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AMP3"/>
    <dbReference type="SMR" id="Q5AMP3"/>
    <dbReference type="FunCoup" id="Q5AMP3">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AMP3"/>
    <dbReference type="GeneID" id="3635637"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401890CA"/>
    <dbReference type="CGD" id="CAL0000196747">
        <property type="gene designation" value="ARL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_01890C_A"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="Q5AMP3"/>
    <dbReference type="OMA" id="VRWSKDQ"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PHI-base" id="PHI:7011"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009826">
        <property type="term" value="P:unidimensional cell growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000510">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000196747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="185" mass="20663" checksum="2F478D2B58BC0E4A" modified="2005-04-26" version="1">MGQAFSFGNIFSKLWGTNKEIRILILGLDGAGKTTILYRLQMGEVVTTKPTIGFNVETLKYKNITLNIWDLGGQTSIRPYWRCYYSNTSAVIFVVDSTDKDRIDTACKELHQMLKEEELQDSALLVFANKQDQPGAMTAAEVSQALSLTDLKDRSWSIVASSAIKGEGLTEGLDWLMDVIKDEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANH8</accession>
    <name>Q5ANH8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C304650WA</name>
        <name evidence="3" type="ordered locus">orf19.13346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723137.1">
        <property type="nucleotide sequence ID" value="XM_718044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ANH8"/>
    <dbReference type="FunCoup" id="Q5ANH8">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="3635192"/>
    <dbReference type="KEGG" id="cal:CAALFM_C304650WA"/>
    <dbReference type="CGD" id="CAL0000193326">
        <property type="gene designation" value="orf19.13346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_04650W_A"/>
    <dbReference type="eggNOG" id="ENOG502QVA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031561_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ANH8"/>
    <dbReference type="OMA" id="HWGCTGV"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000193326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="377" mass="43514" checksum="5C9EA7DC2D01FE37" modified="2005-04-26" version="1">MINVFKPIVQRDLVPTAYYNNEILQYNGVSPKDTPILPFNQTIEDLNRDIYAKPLHSHNDYWREYPLFSALSAGAISVESDIWYFPQSYKLTRTVTPSTSKYNNNNKQGNSSVNETLIFKNDEIYVGHSQEFLKPINTLFNLYLNPLSQFLQFVNPTYEIIDGDSNSENSRLEQDFFAQSQSERNSVFYNNPGQPLYLWFDFKTEANSTYDALKPLLKPFIDNGYLAYYNTTDDKYYSGPLILTITGNLPVEKVTNETIRYLFLDGPLDKFTIDNNNTNKDELKKWSKLSRVASGSLETILGSESYATSTKNDFNEEQKSQLKQVLDLAHEYGLKTRIWGDITWPWNVLDSHLKILFELGSDLLNVDDLERASQLFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AP90</accession>
    <accession>A0A1D8PES4</accession>
    <name>MNN23_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Alpha-1,2-mannosyltransferase MNN23</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MNN23</name>
        <name type="synonym">MNN3</name>
        <name type="ordered locus">CAALFM_C110070CA</name>
        <name type="ORF">CaO19.12338</name>
        <name type="ORF">CaO19.4874</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="PLoS Pathog." volume="9" first="E1003276" last="E1003276">
            <title>The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans.</title>
            <authorList>
                <person name="Hall R.A."/>
                <person name="Bates S."/>
                <person name="Lenardon M.D."/>
                <person name="Maccallum D.M."/>
                <person name="Wagener J."/>
                <person name="Lowman D.W."/>
                <person name="Kruppa M.D."/>
                <person name="Williams D.L."/>
                <person name="Odds F.C."/>
                <person name="Brown A.J."/>
                <person name="Gow N.A."/>
            </authorList>
            <dbReference type="PubMed" id="23633946"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003276"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to hypersensitivity to toxic ergosterol analog, amphotericin B, calcofluor white, and to thermosensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723558.2">
        <property type="nucleotide sequence ID" value="XM_718465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AP90"/>
    <dbReference type="STRING" id="237561.Q5AP90"/>
    <dbReference type="EnsemblFungi" id="C1_10070C_A-T">
        <property type="protein sequence ID" value="C1_10070C_A-T-p1"/>
        <property type="gene ID" value="C1_10070C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3634813"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110070CA"/>
    <dbReference type="CGD" id="CAL0000193748">
        <property type="gene designation" value="MNN23"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10070C_A"/>
    <dbReference type="eggNOG" id="ENOG502S8HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AP90"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="PHI-base" id="PHI:2886"/>
    <dbReference type="PRO" id="PR:Q5AP90"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000428637" description="Alpha-1,2-mannosyltransferase MNN23">
        <location>
            <begin position="1"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="36"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23633946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="606" mass="69650" checksum="04134431AC796400" modified="2017-05-10" version="2">MSINFLSIPRNRFKAIGVLSVTCILIYVILHSSIITTDFDVSDYGDKFIPSIIFDDNNDNGENLKDPQPELDNDKGNGETDTTTSNSMTTAHTFWKGIFDTFDKYKMDLGQDPENAVSYVDKLKQKQGPLNKEVLLSKAIVSSELMKHLKEKHSGVVEDLPSVMPGSVYNKGSKGVVIIGGGKFSWLAYLALVQLRNVGSKLPVEIVMPSRADYEKELEFCENTLPEMQASCVVLPDVLGEAVMKNRKFASYQFKALALVVTSFEHILLLDSDNMIVSNPDEIFESKLYHQYGMITWPDYWKRTISPLFYDVAEIEVNENKRVRYNRFPLYNAPNVRSNIYTDQEREEVPFHDLQGSIAELSTESGQLIINKHTHGKTILLALYYNFYGPNLFYKLFSLGEQGEGDKDTFVAAAVVTRQDYYQVKSFIKTFGYADSDDKFQGVSMGQRNPLIDRKHYEDHVLALLEKDSFKSSSIADQIEQMKKFENEDFDQHNSIPLFTVHCNYPKLDPKLYMSRDDLYDEKEKKLKYRLYGNLKYTKEVVKDGETGTEASTDKVQIDFELQQWQHMQDILCLKKIYFTHFIDNDMNELCQFIENQVAWLSKSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PC77</accession>
    <name>A0A1D8PC77_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">UBP6</name>
        <name evidence="10" type="ordered locus">CAALFM_C100440WA</name>
        <name evidence="9" type="ordered locus">orf19.13484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330601.1">
        <property type="nucleotide sequence ID" value="XM_019475056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PC77"/>
    <dbReference type="SMR" id="A0A1D8PC77"/>
    <dbReference type="FunCoup" id="A0A1D8PC77">
        <property type="interactions" value="1156"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PC77"/>
    <dbReference type="GeneID" id="3639317"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100440WA"/>
    <dbReference type="CGD" id="CAL0000193223">
        <property type="gene designation" value="UBP6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00440W_A"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PC77"/>
    <dbReference type="OMA" id="RKVQFPF"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904293">
        <property type="term" value="P:negative regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="103"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000193223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW25742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="478" mass="54118" checksum="4D829A12A3405F33" modified="2017-01-18" version="1">MAYTITIKNAGKTYDIELQEEDNGQTLKSKIQQLTLIPPERQKILIKGGKLTDEVIVSTLNLKSPVMVLGTPDKNLPSKPVEKQVFLEDLNKNQLVKVSNEPSGLTNLGNTCYLNSSLQTIFHIDDVNNRLKDYTFGGANQANSAFVLSLKSMFQQMSKKQEVITPSTFLSLFRRSYPQFAEQQNGIYKQQDAEEAFSQILSSLRSELKIDDVFKITFNTKTQCLAIPEDVTEGFEEAYKLNCHIGVKTNFLRDGLLAGLKETIEKHNSTLNADTEYETTKTITRLPKYLTVHFIRFFWKRDINKKSKILRKVQFPFELDLAEMLDVSIKADKVSNRDTIRKVEKDNLDMIRDFKKTKNDTSLTPLEQQEEDEMKITSIKSKFKDDLNSALPNVDFNTTTENPSSVYELNAVITHAGSSADGGHYKAYVKDPTDLDGERWWLFNDDKVSSVNKEKIETLAGGGESDSALLLIYKGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCB4</accession>
    <name>A0A1D8PCB4_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ric1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">RIC1</name>
        <name evidence="5" type="ordered locus">CAALFM_C100690WA</name>
        <name evidence="4" type="ordered locus">orf19.13457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718998.2">
        <property type="nucleotide sequence ID" value="XM_713905.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCB4"/>
    <dbReference type="STRING" id="237561.A0A1D8PCB4"/>
    <dbReference type="GeneID" id="3639331"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100690WA"/>
    <dbReference type="CGD" id="CAL0000199231">
        <property type="gene designation" value="RIC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00690W_A"/>
    <dbReference type="eggNOG" id="KOG2006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCB4"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="854"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000199231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW25767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1013" mass="117724" checksum="16463222551E9FA0" modified="2017-01-18" version="1">MVWVNGCPKFSIDLPINEDIIDIAHIYHTPLLTVLTKSGVFVFHQHTLLPLASHVRNTQSIETNGYNIQMKTKHVSVNTAKLQKLSIVNLFIQSENNFLIIYQISINYSGSIYEVHNKNDELIQNGLPLSSTSSGFSVTDFFKSATKSIIHGTEEVSVNLENIENINNGTIEDEIGGFEIEPIKLSIFKILKIGIGLKDFWLQENSHTLFVFNNHDEKTPDNEDDFFQIINVLNFKNKLFSLSEFTWYDSNSRIKYITYNEYFDYFIFVNKKNEIWIMHLGNDQEDMGYKIGTGDIDNISFNPQCHLLIAKDNTSAGGTLNTYMLKNNNLQFLKNLNLNGEIKWSPCGQFFTLLEASGSWKLLSKFGSISFDSQEILNEFDESNDPNRDFLKANIIVISQNASTLYVVTDKKIFYTPLMRANGGLLYDHEYVSVIQSDKRLLRFPILAKYKKIILDRGHFNGRIHKNLSSQTGKLCLDKNSHNQLSISYGDYLAVSTPYSQGDSIYHVLWFNFKNFFADSLNIIHHFWFQDFLIVVNRRSRHTFEENEEVDDVNGNGDYLVDEFMVLDASKTKYGMGGEEISFTSDSLMWKYDFKSTFIDINLSEPTKGKSQVVILTADHRLIVLDLSTNRLIKSDTDIKHYKIFISVNKTVNLSTINAKIELNQVVQTSMINNRHFLFLLATGDIYLLKNQSRETSSSLSSLRTPIEAIKPSNMYDLVKLHSNIEFFKFKSIKFENDIEFVYLFNGQEILVYEVSELIEKSYNDNDREEKPEDVLEFKEEEEENLLPICIHTDGMQPFEFDAVFNHKSLDLIGLNTLAINKPKSGGLFIRNTVSRKLILNNFIEFDLLHKGDLESSFKKYENFKNFHYCLELLLFKHLTNDDYLPLKRLFQLIEFTENSERIYINCLRKIEIGYWHRFFSALETTPEKFMKRLIAIDNVELCYNYLIIYLNYKNEGDTETDELNDHDKEVILKIIKMLESSSKWDWCFELCRFIKILEPSGDFLRQIKQELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCY2</accession>
    <name>A0A1D8PCY2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HID1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C103050WA</name>
        <name evidence="2" type="ordered locus">orf19.10513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721494.2">
        <property type="nucleotide sequence ID" value="XM_716401.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCY2"/>
    <dbReference type="FunCoup" id="A0A1D8PCY2">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCY2"/>
    <dbReference type="GeneID" id="3636843"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103050WA"/>
    <dbReference type="CGD" id="CAL0000182470">
        <property type="gene designation" value="orf19.10513"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03050W_A"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCY2"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000182470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118786" checksum="28985B504E6F0968" modified="2017-01-18" version="1">MKTTEEKTNFRNQFLKLGQGHIISTDESNDVFWSSFWSMPTCANDVYELITVADIKKVRQQNLMNIIQLTRKLCHKVIFIAKESKKFGNNKKETIELLNCVRFLIKVLPFIFELAIYPTELEREIFWNNDFDPMQFLQRLEASRNEDEPEDNNNWERVLSPDQATNSIAVNLMSSLVDLLFIRNFTVASSVSKSSATGKDNKLLHVWEPGIGSTSKYQQPNVMIDSNRTEILKLLLTLCSNSLYQQVSSVTTQGSKFLTLLVTVTPKIELLTLVSSLLNIACRSSKLTGSENGLVFEKQEYSETRHLCVTYSIQLLTLMVVYPLPQKSELKFLSEGGLCSKPYNMARAFMGKIHKENELLFITSSLIDLLKVPLINAKDQETDTFSLLRPGSNYKRPSLWSLEAVMLIWELLQSNRKFAAIVGKKYISELMIILLYYVFAYHNQKTFKNLVFLCAYLLLYLSSVQQDRFLEPLFVPLNSATSLFEFYNCLPSNYKLSITPGNTRDFLVTHICTMLINNQVNVSSSNYLSNSSSLSDLLIKTLIEILYNLIPRVSIEETTGLKTDKSKKLNNPNPRGGLSYQSSSSITQLVGILSNKKFLLEKSFHPDLVALLIRAICAAVTKFPVPSRMLLFCILKNEKVYDELWNTIFSFSGVFFRGNSLTRIEDESDELQSENTEADASIAPYDSKKDEILESTVNPIPIPIPIPTPTNKYEDDGTIKSTSAETENIEASLRPSLPTGMSFKAREKLKKDSPLNKTWAGNDALAILLTIVIPHLKVVLNEVWSRVEGSSVDSYELVQRIEKAGFSKVFETNKSQLCYDLLPNTPLDQLKFNWSHLSLGWYISLLYGQIYNSGAQVQNYSGNSIRSYKIVKTFSSGMSKLTSNWTSFLKQDPQRESNSSEAVVPNIDENLVWVNNALCDVNTWSGSEIKLFNVETTEDGFFANLNSRIMSNYTKNENAAQTSAYGYAVPSTPGGLTDMSRRFSDFRINNGSNPSIRSIGNSPAPSALSTPVEEKELYFSKRSFRNSVTSLHSLNNLNRSRSNTPRNSISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PD47</accession>
    <name>A0A1D8PD47_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">STR2</name>
        <name evidence="14" type="ordered locus">CAALFM_C103760CA</name>
        <name evidence="13" type="ordered locus">orf19.8635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713638.1">
        <property type="nucleotide sequence ID" value="XM_708545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PD47"/>
    <dbReference type="SMR" id="A0A1D8PD47"/>
    <dbReference type="FunCoup" id="A0A1D8PD47">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PD47"/>
    <dbReference type="GeneID" id="3644689"/>
    <dbReference type="KEGG" id="cal:CAALFM_C103760CA"/>
    <dbReference type="CGD" id="CAL0000185051">
        <property type="gene designation" value="STR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_03760C_A"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PD47"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="orf19.2318.1"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
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    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
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    <dbReference type="GO" id="GO:0006673">
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        <property type="entry name" value="Kei1"/>
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        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="34"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
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            <begin position="143"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="231" mass="26025" checksum="75D5A1F38292234C" modified="2017-01-18" version="1">MTLPTYVNHLLPLKFLGVIPLFIGVEVILGITILNKASGVYGILSLFTGHPINFWQWLYNSLAIITLPVYVSALINLKTKPRNLRKISLATIVYVLDTFIGSLYTLYFIYFWFSSEEGSIKSTGADSSSSTLSSQSASAARELFITLGTTISVTFIRLYFTLVILSFAKALLKQNRMETRYNDVQNGTSSRSLEQEEEDEVANATGYFGEFRKAIFDLEVRSKEYLDDLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGH4</accession>
    <name>A0A1D8PGH4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="4">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">FAB1</name>
        <name evidence="22" type="ordered locus">CAALFM_C201990CA</name>
        <name evidence="21" type="ordered locus">orf19.9088</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:filamentous growth"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
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        <property type="project" value="CGD"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="2-Layer Sandwich"/>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
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        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
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    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
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    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
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        <property type="entry name" value="Cpn60_TCP1"/>
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        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="19">
        <location>
            <begin position="485"/>
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            <begin position="2291"/>
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            <begin position="1"/>
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            <begin position="198"/>
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        <location>
            <begin position="315"/>
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        <location>
            <begin position="454"/>
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        <location>
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            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2095"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2215"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2300"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1001"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1921"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="2095"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2107"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="2226"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="2239"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="2304"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2314"/>
            <end position="2326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0000182478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AOW27240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2624" mass="295966" checksum="7C8E8CCCDA349D3A" modified="2017-01-18" version="1">MIGSPPDTPNDMSNSKRKLPLLERIPSHTNNSDDEDSYDKGVVDYVSFPTIPDPEVENTKSITGLLTKTLRKVTTNASTLVQNYSQNYTSPKPNVLDTSPFTNRVSELKATAIGSDALPVPKNDEIVDTPISMDLSTKTDTRLRVKEDTSKRITRSSSPLDLKGDAQGNKLEIMNPIIKSETNRTPIDKVSIVTNETSTGATFKPQQSKQPPSTSTPALSLRQNLIDEVHTPRVTSDNKTLRISTMQFPRMQSMANSTTSSVVNVTASASVDIDNVTNDKSNVESKPTHKKESSIDLKSKDKGLQNKISSIFNNLPNDIELSDDSADESDSTHNEGSENSATPQSDIAYIENRSDSNLSSISKMNNHLQFELSARYGDSVAKSAPIKAESKHSATFTPSFGQSPTVSTFHAIQNKDVSANKQKSLNTPSTLLDNARSIIHQNIEAVASSASSIIASKRRKKKKPTKTSENPLKNGGIPKKYWMNDAFVSDCLNCFRPFTAFRRKHHCRFCGQIFCSDCTLFISYNQHRDERNNTKNSAKKPYNDKLRVCKPCYSDVIIYLSDDSSSANDSDGEKVISAEEIEVPKTKAEDLLVPNHPLSRIRSMSMGSNRDSSRTDSLSRKPSLKDNNNLENSLSTSHSSSPSRSNNNQFIYPDESIKVHPRQAPRMAIPTTRTGEAVEIPLMRHSLMNSSILKTSGAPYSSNMNSLPQTFHQSNSQFYHNHHSSPEHPQYGQKQNSLQQHQPQGGHFHNHYHNTYSNSHSQYNNSAGISESENTNKTRIKSHLSPTLSNANLTSRSLDNLGSIYNSFMTRTPSFNMRVLSGSSRDPSRFRRELSLEPGDIQSIRSKYGKEMTIGGQSDFDDDDDDDDDDDDDDDDENAKNEGVDLSDNEEDEHAMSIYTSLNETHGYGSTPLAHQPPPMHSHSAVTVPTLGEFPIMKSGYPSFRGAMNRSAAANLANVFQNHSIELTGEDPNKHQPENIRSRARAHASLQRMRTRRQAKATRNVSILSQSNLRLPSLEPSNHRPQYTSSLTPIASPASPGGNSSNLTAGIAATDDVSTSSANIDSEMSPIGPQISASTGLEKYHSGERNDYFGSDDHLMATSESRDLISWKDGKTVDNKDKLYNETLDFVLRQSLKDGEIETEIERWVAVLQKSLGYIDEIKLTDTLDIRQYVKIKKVLGGKIEQTELVDGLFMTKNIDSKRMASKISNPRIALLMFPIEYLKQKEQFISLRIIHAQQSVYITNLVSRLVSMEPDIIVVGDSVSGLAEKLFEDAGITVISNVKPQVIERISRYTKADIFQSVNDLFFKKGKLGLCENFAVKRYKYQNQIKTFVFFTGCDIHSGFTISIRGGNTNLLNNVKYAAETLMPGYINARFEKSFLDNLSLSYVKPTENPKIVDIQQKLQEIRDNTIEGDENGKLHDLKLDPAEVVNYVKSFSERKLSLSPPVEYSLPNPLARTIYTYYAVHQFAQQNAKIQKLSSVDDIKEEWLTELKIDYKLEELPGKEANLINILKFASEAHLKLLINEYQARVRIWSNCMKYPSYQLYPICHRNIHLLHSTVSIKHATPCSGPAIIVIDYYTDNDKCFGLFLDQAFHESSKVCGECGETYLDHYKSYVHGKAKVDLIIEKYDIQCLNNGEMQGKNQRVMWSYCKECNYETPIIAMSDETYYLSIGKFFELNFYGEGVSGGCTHDFFKSYVKCFGFNNLVIRLEYSTIDNYEIVVPKKQLEFITNIDIKLKIDAYKFIRTKAEVFFDSVLKRLKRVKLDTFEKAEDGIQKIEELKIKLQEQSDSIYGRLQSIYDKIIPTNYLALNVVLRDLQKLGIYWDNEFNEFERTYLPSENEVNKITQFHLRKFLMDRYNDEDEDNNNNNNKKVVDVTGNESTSGSKETAALDDGKASSNKDCSDKSTPDNSQDSMEIDGDSKNTDDKSTNELSKPFPEFVPKKPRELPMNRNLSDSNIETKMFPQSTLYESGSNISERINKWNQTAETGDKTTPTQLLTHRGSDSSLKSINTVIPSQNKVIHLANFFDKMYYDQISLEFSKQRERELKRKSKVKAQPIFDSKPIVEIYNKIEDVVGPGVDDEKKKDIAVVKKDEQEKGQTKENQQESSQQQSQQQVQQQSQQSQQQVQQQSQQQLDIPEKQSLLKSLTNFWADRAATLWDPLNYPLESHEHTFADSEVIVREDEPSSLVAFCLSSNDYKQKIKNAFEKNRMGDSGILNSNLQENKPHNDKPGVESEVGNSGITTESASIVTSVGDTKLEESSINNSSNAKAGESLLASDNKKGAQFAKIEKKFKKKLNKEGGINGGGGGTNNSGDNNNNDDNINPLESILTRNKSNHLKYQFIDGNTNLSCKIFYSEQFEALRKACGNDDNFIQSLSRCVKWQSSGGKSGSSFLKTLDNRYILKELSKSELESFVSIAPFYFKYISQSMFNTLTTAIAKIFGFYQVQIKNTTTGKIFRMDFLIMENLFYNHKTTRIFDLKGSMRNRHVQQTGKENEVLLDENMIEYIYESPVFVGQQSKKLLRGCLFNDTSFLSAMDVMDYSLVIGIDDSSKKLYLGIIDWLRTFTWDKKVENWVKGNNLIGGNKRGKDPTIVTPKQYRIRFREAMERYILEAPDIWYEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PGX4</accession>
    <name>A0A1D8PGX4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier family 66 member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C203290WA</name>
        <name evidence="10" type="ordered locus">orf19.8518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721020.2">
        <property type="nucleotide sequence ID" value="XM_715927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PGX4"/>
    <dbReference type="STRING" id="237561.A0A1D8PGX4"/>
    <dbReference type="GeneID" id="3637429"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203290WA"/>
    <dbReference type="CGD" id="CAL0000186796">
        <property type="gene designation" value="orf19.8518"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03290W_A"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PGX4"/>
    <dbReference type="OMA" id="WAERLFT"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000186796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="282" mass="30936" checksum="E4F86E9F13D87898" modified="2017-01-18" version="1">MGSPIIMLIKLLLDPDVSKKVILQMAWSQVKAIGIGKVIAALLSALTVGVSSFIRVPQIRKLLINSEHDRIAVANGLSLTSLSLDTLNSLIHVTFNSQNRIPFIQYGESLLLGIQNAIIILLVKFYRGQETAGVGKWQGLNCDDKFAAIRGAVTKPLVIMIASAIFFNKLAPSSLISALEILNIPISIVAKFPQIKTNYELKTAKHLSDTVLRANVVGSLIRVYTSFTDYSTKKQRNKNTVDETILLAGYSTSLILNSILLGQSIVYDKLGEKKVEDEKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH70</accession>
    <name>A0A1D8PH70_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C204500WA</name>
        <name evidence="15" type="ordered locus">orf19.11978</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 16" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1314"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1676"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1845"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1850"/>
            <end position="1859"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    <sequence length="1915" mass="213986" checksum="BCE5B04D51CF1259" modified="2017-01-18" version="1">MSRLDRLVVLLETGSTPFIRNTAADQLSDLAKAHPEDTINLLGRVYPYLKSKKWETRISAARAFGGIVNNAPLWDPNSEKQIKLEKDAEQVFVKEEIETDPIVKKEFPEDEIIIKKEQDEELQKLTKNLSNLINFDSFSLHELIKCGTKLLASKSDDTDREDYINDVTLLGRIKRHRSSIIPKEETKSDLSKESSPNAHTKEEPIIKQEPGTQQQHDNLASASTSPAPPTGSNKPVSSARLKAMQRRKAKANAKNGANKIRSVDISQSSLSRQMIENGEGMDIDSKDSTPQFDVTSQQGGNKLVVETKSSELSPLLSQQNKVAGLIWQFQGVYELLLADLFDDQWEIRHGAALGLRELVKKHGKGAGRVMNKTLQENDTNNAATLEDLAVRICVIFVLDRFGDYVSDTVVAPVRESAAQTLAALLIHLNEETVIRIFHCLNSMVLQKDMVAKCWEAKHGGILGVRYLVSVRTDILLANPEMFDDVVTMVLSGLKESDDDVQSVAALTLTPIASQFVTTRKNVIGTLLTVIWDCLVNLRDDLSASIGSVMDLLAKLCSHKEVIEIMQQDANENKENSFENLVPRLFPFLRHSITNVRKAVLRTILEFLSIEDSSTKAWINAKTLRLVYQNLLVEQNIDVLNLSAQVYEKLLLEMNNNKFNIDVIFTKQSKSLLTLTMTPIGISRHTYSMNTTLIMRPSGEMLGPLNDDDCRGKKRKPDESTTDIPIEDLKVNIDSPIYKGDVMLVGYDKLIGMRCAASAAFGKTLSYMQSEETLLKIFEAISGYLKSCHATSVLLSAFIVEEYATALKERGLKPNEKIVTLLSGSLNKVLQEPESLPHFRELVPTLKAVRTSCLQLFDVFVTAAKLSPSRIPQIPVVVQGEAEAGPGAFGLETAEKICNETFVKLKKHLSATHRLSANQALEDAKHRILVAMEESRLAFTSRANSIFAGFAAASLALAGVPKKLNPIIKSLMESVKSEETLVLQKRSVFSVARLVQQLIEVGKKGASDKIVKNLCAFLCVDTSEVPEFHHNVIFKENILSLRKEEAQIDPTDAAAHERAVREAKIKRNGALMTLDQLVHIYGPKLFDQVTKLKEMMIEPLRYLSKTEEVSQDELKGQSVIDALGILRALFPKMDKELYPEVIDNLDLFLPGLQSEYSVFRYSTAKCLATICSVVPAKAFIFIVNSVLPMLKNAGDVKQRQGAIETVYHISAAMGASILPYVMFLIVPVMGRMSDSDHDVRVLAATTFASIIKLVPLEAGIPDPEDMPQELLEGRDRERDFIQQMMDPTKIKSFDLPVTIKATLRKYQQEGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIVSSDHHIREENFKETGSAEYRKLPSLVICPPSLIGHWEQEINQYAPFMKVLVYAGSPSIRIPLRGQIPDADVVVTSYDVCRNDVESLTKHDYNYCVLDEGHIIKNASSKLSKSVKRVKAEHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKVFHEKFAKPIAASRNSKTSSKEQEAGALAMESLHKQVLPFMLRRLKEDVLSDLPPKIIQDYYCELSDLQKKLYKDFAKTQKETIKTDVQGSEKEGKTHVFQALQYMRKLCNHPALVMSEQHPKYAEINQFLISRNTDLRNIEHAPKLLSLKNLLLECGIGSQDSEYNNNVSKKKSLQQQQQQQLISADGVISEHRALIFCQLKDMLDIVENELLRKYLPSVTFMRLDGSTDPRDRQSIVRKFNEDPSIDVLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRLGQKKVVNVYRLITKDTLEEKIMGLQKFKMNIASTIVNQQNAGLQSMDTNQLLDLFDVDDTGNGAKVEEPVKEETDTNGGGGASTNGDIPDDITGGLTGKAAGAVGELADLWDESQYEEEYNLDNFIKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHD1</accession>
    <name>A0A1D8PHD1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C205270WA</name>
        <name evidence="8" type="ordered locus">orf19.11040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714915.2">
        <property type="nucleotide sequence ID" value="XM_709822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHD1"/>
    <dbReference type="SMR" id="A0A1D8PHD1"/>
    <dbReference type="FunCoup" id="A0A1D8PHD1">
        <property type="interactions" value="1259"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHD1"/>
    <dbReference type="GeneID" id="3643470"/>
    <dbReference type="KEGG" id="cal:CAALFM_C205270WA"/>
    <dbReference type="CGD" id="CAL0000191099">
        <property type="gene designation" value="orf19.11040"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_05270W_A"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHD1"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="476"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000191099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="948" mass="106714" checksum="366CAE1082619016" modified="2017-01-18" version="1">MSWTPDPQALEQLKHIFKGTLSSNNEERRLANEALIQAKQQPEIENYLFTLLIDDGNGSSNGTSNGSTTATTGTTTTTRSDVRAAAGINLKNNILKNKSIDRTYLINNIMKGLMSPDSLVRNITGNVITSMFSIYGLDNWSSALTDLLNLIQQPPIGDNNNNSYIPQEAAMSALSKICEDSYLELDREFQNNRPLNYLIGEFLKLIEQHPSGKIKAGAIHCINQFIPLNTQSFLIVLDDYLNKIFNLAGHDGQQNNEVRKNICTSFLLIVETRPDKLLPHLDGVINYCLHLMQQDTSTEVSLEACEFMLALATNKELNVFTPEKLKIILPILLDKMVYSEEEIFLIEIADSKDDANVVDKDEDIKPTNAKSKETRNGNSRNSGSGDDNGNDDDDDDDDDDDDDDGELEQWSLRKCAAATLDVLSESLAQEVLLVTLPILQEKIVSPNWPIREAAILAFGAMSNSFMKLSGNELPSLVPFLVDRLQDNEPRVRQITCWTLSRYSTWVSEEAHEGGQYANYFQPTFQSIVACALDSKKIVQEAACSALSSFIEESDASLIEFYLEPLLHHFAKCFQVYQRKNLVILYDCVQTFVEKMGYENLSLKPEYPQTLLPPLLSKWEQLDDDDTDLWPLLECMASIAASLREIFAPYAVPVYERATKILSNCILLDQECHTDPAIDPPEKDFMVTSLDLIDGLVQGFEYHSVDLINQNHKSNLIELMLICFEDYNGDVRQSAYALLGDLAIFTIELLKPYLRQIFISIGNEINNRTYETYPVYNNAIWALGEMIIRLPIEETKPYIDNLVDLLIPVLNSNDIQSTVAENAAICLGRMGINAAELVNGKLNQFIEAWCSRFLYLIDNNEKETGFQGIINMINLNPDNGFGGLSTQHGKKNLAAFLACIGNYQEIPSNELQHLFIDLINNYKSLLGNENWNQILQFIDPEIRNRLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHQ5</accession>
    <name>A0A1D8PHQ5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">U4/U6-U5 snRNP complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C206650CA</name>
        <name evidence="11" type="ordered locus">orf19.8876</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_709983.2">
        <property type="nucleotide sequence ID" value="XM_704891.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHQ5"/>
    <dbReference type="SMR" id="A0A1D8PHQ5"/>
    <dbReference type="FunCoup" id="A0A1D8PHQ5">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PHQ5"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PHQ5"/>
    <dbReference type="GeneID" id="3648419"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206650CA"/>
    <dbReference type="CGD" id="CAL0000177683">
        <property type="gene designation" value="orf19.8876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06650C_A"/>
    <dbReference type="eggNOG" id="KOG2574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHQ5"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="271"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000177683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW27666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="569" mass="64026" checksum="85D1BCC9351758BA" modified="2017-01-18" version="1">MTDYEQELLDDLDSSNDEQEELEQTDNPQEEEEDGDGDGDEDGSMDFNIQLQQLIESNSSNIINEFDKLDIETINDEDLIKLSKIYPLIPQLKQKIIQYSNEQELDYLELITSTTTTNSSSSSSSIYDNYGENSQEYKFILLINELSTIINNEIERFHTLIKLKYNLIFPELESLIINKIDYIKLIKIFKQDLSNIKSYESQMKLIIDNEKVLVIIMAALQQQVSTNTNSTSGLLSNQIMNKILIVIDIIEQLNDLLQLLSKFISDKLAKFAPNVSAIVGPITTSQLLIATGSLKNLALTPSCNIASLGIRDLSTKKKTTTPRNSNSKNVRQTGYIYHSELVKYIPIDIIRSVMRIISGKIVLAARIDSSKSNPNGELGETYKQEILTKIDKLLTPPQQSIDKSLPKPIEMKSKKRAGRKYQKLRAKFEMSELRKAQNKLQFGKQEDTIMNGLGEEIGLGMIKSGGGGGNGVSISSGRIRKLPTTTTTKGAKSNLNLSKNMMNRLNEKKEINPIKAFDEFNLESFFKPEKTTNITAKTNTNTNTNISADNNNNKSINSNKWLNGFTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI58</accession>
    <name>A0A1D8PI58_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">ALG7</name>
        <name evidence="22" type="ordered locus">CAALFM_C207940CA</name>
        <name evidence="21" type="ordered locus">orf19.9733</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
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            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
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        </reaction>
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            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C207940CA"/>
    <dbReference type="CGD" id="CAL0000195644">
        <property type="gene designation" value="ALG7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07940C_A"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
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            <end position="17"/>
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    <feature type="chain" id="PRO_5009111113" description="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" evidence="20">
        <location>
            <begin position="18"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="71"/>
            <end position="93"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="161"/>
            <end position="177"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
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            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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            <end position="352"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="358"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
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            <dbReference type="PubMed" id="17419877"/>
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        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
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                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <dbReference type="InterPro" id="IPR041808">
        <property type="entry name" value="Cue3_CUE"/>
    </dbReference>
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        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="325"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0000194330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW27782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="454" mass="51251" checksum="B5D9B8F4C2FB9AE4" modified="2017-01-18" version="1">MNDTEDTIYIPIPHYPPFKLRSSLIDKDPVIWVHLLEAYIHLMTVLLDPETPKLNVKSQQQLQLFLKIFLFETCEEETKIFSLGAINPDIKKNTSILNAYVFQLIKKYSFVKLNLTGEAIWNFTKIHAPKNISTVRGLIDGTFKSEFNDNKKSGNISSISPVQKHLDLIVTNGKFTKTEDLVILSMLLGQNTTRTSTFSMGSNKSINKKRNRSLPFAENFVNVQWIELLEKGYANGKSVNADIIKDIMIISIISLSAEKLATLTMNLGITSIAAFNVCPLFSSIIISEPYKELIPNLEKKLPFLRNIDIDDDNGYEDDDLDGYEDNIEGISILVDLWPNMTERKAKIILKQHNGDVEHVTNLLLENPELIDKIEMPKKTNNGTASTSNNTKTFTGSYKIFSGKKKGSLNNNTKLNAPSADLKKKTLESALRLMYQSDEDEPDDTYDDQEKTTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJD2</accession>
    <name>A0A1D8PJD2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C302180CA</name>
        <name evidence="11" type="ordered locus">orf19.9194</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721705.2">
        <property type="nucleotide sequence ID" value="XM_716612.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJD2"/>
    <dbReference type="SMR" id="A0A1D8PJD2"/>
    <dbReference type="FunCoup" id="A0A1D8PJD2">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PJD2"/>
    <dbReference type="GeneID" id="3636643"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302180CA"/>
    <dbReference type="CGD" id="CAL0000180114">
        <property type="gene designation" value="orf19.9194"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02180C_A"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJD2"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008216">
        <property type="term" value="P:spermidine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000180114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW28255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="379" mass="41634" checksum="D67410E53A3A8EEA" modified="2017-01-18" version="1">MSGSGKLPGLASDAVLKQSIPVPEDFQEVKGIDYSQDNAYNMRAKDLIKSMSTMGFQASSLSQACDIIDNMRSWRGKHKDTLEEHEQTGEFDDEGYQKTTIFMGYTSNLISSGLRDTLRYLVQHKMVSAIVASAGGVEEDLIKVLAPTYMGDFTLPGKGLRDQGMNRIGNLLVPNDNYCKFEEWIVPILDKCLEEQEEAMKKLGPKGLIAGSEAIWTPSKLIDRLGKEINDESSVLYWAHKNKIPIFCPALTDGSIGDMLFFHTFKASPQQLRLDIVADIRKINSMSMAASKAGMIILGGGLIKHHICNACLMRNGADYAVYINTGQEFDGSDAGARPDEAISWGKIKAEAKSVKVYADVSLVFPLIVAATFASEKPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJI5</accession>
    <name>A0A1D8PJI5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C302360CA</name>
        <name evidence="9" type="ordered locus">orf19.9176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721687.2">
        <property type="nucleotide sequence ID" value="XM_716594.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJI5"/>
    <dbReference type="SMR" id="A0A1D8PJI5"/>
    <dbReference type="STRING" id="237561.A0A1D8PJI5"/>
    <dbReference type="GeneID" id="3636617"/>
    <dbReference type="KEGG" id="cal:CAALFM_C302360CA"/>
    <dbReference type="CGD" id="CAL0000199840">
        <property type="gene designation" value="orf19.9176"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_02360C_A"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJI5"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
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    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000199840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="588" mass="66019" checksum="461A6889BBA67E5E" modified="2017-01-18" version="1">MTVTSSSSKQPNFLIIVADDLGFTDLSPFGGEINTPNLNKLATGANGVRLTDFHTASACSPTRSMLLSGTDNHIAGLGQMAEFAQRHPEKFNNQPGYEGYLNDKVVALPEILQDNGYHTFISGKWHLGLKKPYWPNKRGFNKSFTLLPGAGNHYKYITRDSQGNQIPFLPAIYVEDDKELLQPEIELPDDFYSTNYFTDKAIEFIKETPEGKPFFGMITYTAPHWPYQAPQDKIAKYNGVYDNGPEELRQKRLQSAKNLGLIDTNIIPHPIKTIRKSWDELTSLEKLKEIKIMQTYAAMVEILDENIGRLIDHLNSIDELNNTFILFMSDNGAEGMLMEALPLTNQRINKFIDEYYDNSLSNIGNKNSFTYYGDQWAQAATAPHAMYKMWSTEGAIVCPLIIHYPNLFSSSAVSGGGSGDGDGDGDGGKILKEFTTVMDILPTILELANVSHPGETYKGRQVVKPRGKSWVNYLINKTDQVHDENTVTGWELFGQQAIRKGSFKAIYIPKPFGPEKWQLFNIIEDPGEINDLSESSSEYQTILNELLDHWAVYAAETGLIELGSDLFEKEKIEGESNEVVYRTILDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PK85</accession>
    <name>A0A1D8PK85_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">PRE3</name>
        <name evidence="13" type="ordered locus">CAALFM_C305560WA</name>
        <name evidence="12" type="ordered locus">orf19.6991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714697.1">
        <property type="nucleotide sequence ID" value="XM_709604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PK85"/>
    <dbReference type="SMR" id="A0A1D8PK85"/>
    <dbReference type="FunCoup" id="A0A1D8PK85">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PK85"/>
    <dbReference type="GeneID" id="3643660"/>
    <dbReference type="KEGG" id="cal:CAALFM_C305560WA"/>
    <dbReference type="CGD" id="CAL0000200252">
        <property type="gene designation" value="PRE3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_05560W_A"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PK85"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000200252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW28567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="214" mass="23301" checksum="7CF114B886A29DF4" modified="2017-01-18" version="1">MNGISVDINHLKKGEVNLGTSIMAVTFKDGVILGADSRTTTGSYIANRVTDKLTQIHDTIYCCRSGSAADTQAVADMVKYYLQIYSSQLPPGETPTTNIAANVFQEICYNNKDNLTAGIICAGYDRKNGGSVYSIPIGGSIHKQNYAIAGSGSSYIYGWCDENYKPSMEQEQCVEFVKTALSQAIKWDGSSGGLIRMVILTKNGVERRVVYLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PKD4</accession>
    <name>A0A1D8PKD4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C306040WA</name>
        <name evidence="8" type="ordered locus">orf19.7385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716626.1">
        <property type="nucleotide sequence ID" value="XM_711533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKD4"/>
    <dbReference type="STRING" id="237561.A0A1D8PKD4"/>
    <dbReference type="GeneID" id="3641745"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306040WA"/>
    <dbReference type="CGD" id="CAL0000176267">
        <property type="gene designation" value="orf19.7385"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06040W_A"/>
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        <source>
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            <dbReference type="PROSITE" id="PS50103"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="501" mass="55426" checksum="1D749E07B4EE65C3" modified="2017-01-18" version="1">MMGITHLVSDNDTVNRQNYSHNHNDGDQCFYPSQDYQRQHQQQQQSSATYSSTYSVTGKKYSHNNSTNQGNHGFRSTSDIFSNQVQLPPNTGPAGTVAVTNGSNSTNNKNLSHVPCKFFKQGVCQAGNSCPFSHNLEGALGADKLPCKYFQKGNCKFGLKCALAHFLPDGTRVNSKSFLQLNGNGKPNNHRGSFGSYTASSYPIDYSPPEYEKSFVDANNNGIESSPSNTVFATQNSKTTSFINIGNGTSSSLQQQYQQPISLSSVPQESLDRSRSFNRSNSLQNIPQPDNTPSSPYSQQPKISHQRSLSMQHHPSIFLVSNSFNNGLSNASNGFSFRSNPPLGRSNSISLSNNDDDHIPVQYFTHNANVQASPQETHSATTPTSRFSFNSRLSSQQFIQQQQQQQQSSSQQQQGHGYYYTESSSSAIVDDDDYPAAKNEFMFEEDFIPGSLSDVILTPQELKRRDSRSQSGNLNVRPSLNNLFESQTQPTHDNGNVFLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL57</accession>
    <name>A0A1D8PL57_CANAL</name>
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        <recommendedName>
            <fullName evidence="3">AAA protein C-terminal winged helix domain-containing protein</fullName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_707532.2"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C400710WA"/>
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    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="102"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0000175463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="645" mass="75272" checksum="A631DCAA281D43E2" modified="2017-01-18" version="1">MFRSISRITRSCQSYPRQTHFRLFHSPTRLKFNQIVDNFLQDLKQDEQENSGGNKNNGKKSGSGKDSNDRFEKFKTFLLKCFETIGITLSSVGVLGLSGFLYHRYYNMHVLRKMNDAFETGDPSAQLKMHTRTHDDSLEDEINAHWVDRPQQKLLNDIIAGDIIGRYFLIIGEKGTGKTSLILESMKRVNGFNVCIFDAHADPEIFRIRLGKALNFTFNEDYIGSLFSIRGPRDTTALLDIERAFSKLEELAIKRVNKVHKPLIMIINNAHLIKENEEGVKLLELLQQKAESLSGSGLLTMIFNSDDYWVYEKLKQLGTRLELINVRDFNRMETINALKFVRHRYFPKLEKLDDELCNAVYDLIGGRPQHITQVARHRDIMKACHQIIDREKTWFLNQCGLLGDDMDDDVMESGKFSSSAMLLMREFVEMDRQKSNPLLINSSSSDGTHSSQLMNHRLPELPLWRARQIMTRPDYIQRFDNLNIFTIDSESRVRADSVPMMRAFHEIASQPHFDQLLEDTIDRVADIEALGRTRELVLKDLQLGSHYEMLKKKHPEGENFKFTMIKSPKQNDLHGDFDKYNTEEINQADDDDEDEDDLYLEEINRKDSRKWWKKRMQKYDRLFLPDDNKHSEEGDLDINRPREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL95</accession>
    <name>A0A1D8PL95_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rlm1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">RLM1</name>
        <name evidence="11" type="ordered locus">CAALFM_C401260WA</name>
        <name evidence="10" type="ordered locus">orf19.12132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722733.2">
        <property type="nucleotide sequence ID" value="XM_717640.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL95"/>
    <dbReference type="SMR" id="A0A1D8PL95"/>
    <dbReference type="STRING" id="237561.A0A1D8PL95"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PL95"/>
    <dbReference type="GeneID" id="3635703"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401260WA"/>
    <dbReference type="CGD" id="CAL0000179414">
        <property type="gene designation" value="RLM1"/>
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    <sequence length="601" mass="66114" checksum="ECF858C93EEBB913" modified="2017-01-18" version="1">MGRRKIEIEPLTDDRNRTVTFVKRKAGLFKKAHELAVLCQVDLTVIIVGNNNKVYEYSTVEANEIFNAYNKTIKVRKQVHESKSPEYYSKFRKKRHLNEPLMNKSGSVVGTNTHLNDEDYDHNVHEAGDEDSEYESDDNSPQPKRHKRSESVKKEQNPKVFNSTQPPPPPPPPHISLNNVPTFTNPQNYKKQIDETNNTSAPPATGTKNEPTMQRPVLRVQIPNDAKSNTNNSHSGVNNSDGKDTARTVTAVDNSATNQNTQSSNTTSGTGTADTNSSQLNSNGNSNLVPANVPNTRFSGYSSFRSPDSRKPTLPLPLQTKSQTSSPASAVAPGLPLTGGSNAYFAGMQQSPVGGSYVNYPAQVYQQYQQFQNQLQLQEQQQQQQKQQSQPQPSSQSVGNQNAQLESAARFRSGLPTGTQFNNGEQTPISGLPSRYVNDMFPFPSPSNFLAPQDWPSGITPTTHLPQYFVNMPLSGIGSQQSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNAQQQSQVPVIPIQTQTSQQMASTTNHKSANLIPGFLQNPTQATGNSANASKSSDAGDGTNPTTAGSSSSADVNNTNNGPNKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLA9</accession>
    <name>A0A1D8PLA9_CANAL</name>
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        <submittedName>
            <fullName evidence="8">Hap3p</fullName>
        </submittedName>
    </protein>
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        <name evidence="7 8" type="primary">HAP3</name>
        <name evidence="8" type="ordered locus">CAALFM_C401390WA</name>
        <name evidence="7" type="ordered locus">orf19.12116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="CBFA_NFYB_domain"/>
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        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
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        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="278"/>
            <end position="308"/>
        </location>
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            <begin position="122"/>
            <end position="133"/>
        </location>
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            <begin position="157"/>
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            <begin position="192"/>
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            <begin position="225"/>
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        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000192077"/>
        </source>
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            <dbReference type="EMBL" id="AOW28921.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Thorstenson Y.R."/>
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    <reference evidence="3 4" key="2">
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                <person name="Martchenko M."/>
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                <person name="Dignard D."/>
                <person name="Hogues H."/>
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                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000180070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="197" mass="21538" checksum="FA0CB769317256BB" modified="2017-01-18" version="1">MSDKPKNENKLPDILKIDEITSGKVDPQLIYDEIERLKAEINTLRNDMSLFLQALATIPPNQSQTEYYKLVVSRLKKVQDSIDDYCEKYNKLLPIINLAQIKLGHDVEGPPPSKIKSETSTNNNTPNMGNKTTPVMGNKTTPVMGNSSTPSIVTANTNTAAYSTSSNTAAKPTKKATKRASVSNKDMGSSANQPIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PN03</accession>
    <name>A0A1D8PN03_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 22">Folic acid synthesis protein fol1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">FOL1</name>
        <name evidence="25" type="ordered locus">CAALFM_C500770CA</name>
        <name evidence="24" type="ordered locus">orf19.8210</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="25 26" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 22">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 22">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 22">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714207.2">
        <property type="nucleotide sequence ID" value="XM_709114.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PN03"/>
    <dbReference type="SMR" id="A0A1D8PN03"/>
    <dbReference type="FunCoup" id="A0A1D8PN03">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PN03"/>
    <dbReference type="GeneID" id="3644123"/>
    <dbReference type="KEGG" id="cal:CAALFM_C500770CA"/>
    <dbReference type="CGD" id="CAL0000194395">
        <property type="gene designation" value="FOL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_00770C_A"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PN03"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000014">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000010">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016261">
        <property type="entry name" value="Folic_acid_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000741">
        <property type="entry name" value="Folic_acid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 22" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="13 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="23">
        <location>
            <begin position="469"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="CGD" id="CAL0000194395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AOW29519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="788" mass="88329" checksum="343193DEB03FE675" modified="2017-01-18" version="1">MLKNDTVFTKDISCTAITGKDAWNRPTPQPITISLSFSTDFQKASELDNLKCSINYAVITRNVTEFMKSNEHLNFKSLGNIAQAISDIGLDQSRGGGSIVDVTIKSLKSEIRAESVEYKINRNTLGQPVPLDIFQVNKLRLLTIIGVFTFERLQKQIVDVDLQFKIAPNSNLYFHQIIADIVSYVESSNFKTVEALVSKIGQLTFQKYDGVAEVVATVTKPNAFSHVEGVGVSSTMVKDNFKDMEPVKFENTIAQTNRAFNLPVENEKTEDYTGYHTAFIAFGSNTGNQVENITNSFELLQKYGITIEATSSLYISKPMYYLDQPDFFNGVIKVNFQNISPFQLLKILKDIEYKHLERKKDFDNGPRSIDLDIILYDDLQLNTENLIIPHKSMLERTFVLQPLCEVLPPDYIHPISAESLHSHLQQLINDKPQETVQESSDLLQFIPVSRLPVKDNILKFDQINHKSPTLIMGILNMTPDSFSDGGKHFGKELDNIVKQAEKLVSEGATIIDIGGVSTRPGSVEPTEEEELERVIPLIRAIRQSSNPDLSKVLISVDTYRSNVAEQSLLVGADIINDISMGKYDEKIFDVAAKYGCPYIMNHTRGSPKTMSKLTNYESNTNDDIIEYIIDPKLGHQELDLSPEIKNLLNGISRELSLQMFKAMAKGVKKWQIILDPGIGFAKNLNQNLAVIRNASFFKKYSIQINERVDDVTIKHKYLSFNGACVLVGTSRKKFLGTLTGNDVPSDRVFGTGATVSACIEQNTDIVRVHDVKEMKDVVCISDAIYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNG2</accession>
    <name>A0A1D8PNG2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C502510CA</name>
        <name evidence="2" type="ordered locus">orf19.11739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720571.2">
        <property type="nucleotide sequence ID" value="XM_715478.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNG2"/>
    <dbReference type="STRING" id="237561.A0A1D8PNG2"/>
    <dbReference type="GeneID" id="3637767"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502510CA"/>
    <dbReference type="CGD" id="CAL0000180776">
        <property type="gene designation" value="orf19.11739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02510C_A"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNG2"/>
    <dbReference type="OMA" id="NNDMIIL"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000180776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW29676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="388" mass="42492" checksum="9E0D9C8760811859" modified="2017-01-18" version="1" fragment="single">MNTGSSQDSIPIDNISLGLSTSPLNTISSGGSDSTIGHLNTPPTSRARSGSLFSIWNEPSVNHNNNVSHSHEMATSTSRNRSYTTTAALPSITIDSFSESLQKSSAPRVSTSPFISVPNNDMIILDNFQTNLPRLRSQTISGTPISSQSTLPHPSESLNAPHHFPQVFETVSSNPSSASILPYNQSPQLFDDVDFTRFLITTSFDNPNLGPTKYLLFDNLPLIINAHKLFGVLSNSLNPRMGNIHGIRITTTTTSKLALVECTSIDTAMSLKASFNHLELVPGNILYVAFAKVDDVQNIGQQRVQPQHSQQLPSPAQPLPQLQQQQQQQPMPLPQLSPNHNTNHNHNHNHNHNQQPQLVQHSLPDKSEKPDPTDILSIQQNLMNSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNM0</accession>
    <name>A0A1D8PNM0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C503150WA</name>
        <name evidence="3" type="ordered locus">orf19.11824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720652.2">
        <property type="nucleotide sequence ID" value="XM_715559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PNM0"/>
    <dbReference type="FunCoup" id="A0A1D8PNM0">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PNM0"/>
    <dbReference type="GeneID" id="3637799"/>
    <dbReference type="KEGG" id="cal:CAALFM_C503150WA"/>
    <dbReference type="CGD" id="CAL0000182798">
        <property type="gene designation" value="orf19.11824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_03150W_A"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PNM0"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001402">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001993">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="209"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000182798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="639" mass="72407" checksum="9180AD281067D5D8" modified="2017-01-18" version="1">MTTKSRNQPLSLNTNQSGTGAGTSTDSIPAGSHITDTNQSFLLPGLASPPTISNTAMFQNPAPHTIRKMDLSIEVPPHQLENNEQNTTPIDINMNMLKHYEILQLPTPIFNTGSFANYNQPLSSLSSNSSNASISMSPPTFRSISRVCSLKQPKRYVSEPIPISTSTSENKVTTSPITPSSSPPTLQQEEIAKKEKQKIFYSKRLGLSFNFVEEIGKGNFSHVILAKTNIYNSDNNGNSVNNNTNDNQEVVDLAVAVKIISVPMESKQQVHNFKSFIRRELNILYHISHHPCITSLIDYDISLDIPIEQIESDVIIDDDELYQKTPPQNLSMNPHSDVGKSSSPDQFIFMNYCNGGNLLHFLQKNNSKHHYLHNHHHHHHHHNHQQGHHDTIQYWQFLKRIVCELIVTTAFLHKNLVIHRDLKLENILLLHDFDSLASLTSSIPFDKLLMSNAISNLSDFGLSKKLATQDQLLSTRCGSQDYIAPEILMGLKYNGKLTDTWSIGVIIYSILENRLPFDIPPPSSTTHYNSSTSPNRGSPTVIKRRRSKTNSTAYRIAMIDWEWSKLDNDNIERYQESVKEKENENDPIPSEVLVIWKQLKSVVDTVLVRKEKRINVEQMLQMDEFKWITDCLPDFIVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PNV0</accession>
    <name>A0A1D8PNV0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fgr42p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">FGR42</name>
        <name evidence="3" type="ordered locus">CAALFM_C504020CA</name>
        <name evidence="2" type="ordered locus">orf19.3209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714338.2">
        <property type="nucleotide sequence ID" value="XM_709245.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1D8PPJ2">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPJ2"/>
    <dbReference type="GeneID" id="3644042"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601220CA"/>
    <dbReference type="CGD" id="CAL0000187685">
        <property type="gene designation" value="orf19.7778"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01220C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPJ2"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900429">
        <property type="term" value="P:negative regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="413"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000187685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66683" checksum="A192FDF559AFCA97" modified="2017-01-18" version="1">MSLTSKELNYLIWRYLQESGYDLSAYALDQQSQCSEYENNPTTQELIQKIKPGCLVDLIQKGILYMAAEQEATDSTTNLSLYGALIQDDLNNLKDNNNISNGSNGSRFALKSEIETNGEQKDSEKQTNNDKDNQDIEMTDALNKEVQQQEIIEFETQLLSPQLKFAPSLTCDWHPTTEVFAYGKDDGTATINAIQDGKIIETRTLTHPNLLNIKNQINIVSWSPQGSLIITCGANSELRAWSPDGKLKNIASTIVDEAISLENTKLISIISSLSWSPTGKFLLSIDSSNQVCIWDGTTISLIKQIKNLEINDDSVVCSCWLSEDKFAVTTNTNGIKIYDILQPPSSHFGNQLDVQPIGLLNGHEHNISLMKLNPVTKLLATCSDFDYSIKVWSSSSSQECLDLNINPEKKYTLKLHAAPMIGLIWLPDSNSNERSLLLSVSMEGILNIWDAKTSENIKSSELFNNKDNFTNELKDDDNNNDNNNNDTTIKDVLVFNAVLSPDGKYLALGDDYCRVTIWDVDTTHYLNEPKDLIRCKAVYKPEISAEDKLKATIGICDMKWDHESKXNMCFLQWYGKCYNQHNIKXPKKKKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPP4</accession>
    <name>A0A1D8PPP4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucan endo-1,3-beta-D-glucosidase 1</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Daughter specific expression protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">ACF2</name>
        <name evidence="20" type="ordered locus">CAALFM_C601690WA</name>
        <name evidence="19" type="ordered locus">orf19.10921</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716726.2">
        <property type="nucleotide sequence ID" value="XM_711633.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPP4"/>
    <dbReference type="SMR" id="A0A1D8PPP4"/>
    <dbReference type="FunCoup" id="A0A1D8PPP4">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPP4"/>
    <dbReference type="GeneID" id="3641613"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601690WA"/>
    <dbReference type="CGD" id="CAL0000196081">
        <property type="gene designation" value="ACF2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01690W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPP4"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000008">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="17">
        <location>
            <begin position="72"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="18">
        <location>
            <begin position="376"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000196081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW30106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="734" mass="83057" checksum="8C20D3F927BAB0FE" modified="2017-01-18" version="1">MGLRDLKNVFKRKEYDRPPAPPPPRSQPNEEPIRDSNPAPTSTQPVNGKDILSNPIATGEPPSLFKRFKHQQQPIGCCCDEKDAPIHTNNFYNNLTTGDQTMPIWPLPYSMWYSIDPDQDHGIAFNHTDASQRVFGPEPDAPVAQYYFNPPKIKSFVLSAENFNGNKLTLSDHRALSVTATLQKGDSKIIFPIVQGMGFITAIYENAKPVIASQVGVQEFKKQNKIGNFQKYTAMLFNQVTWSIYSTNELSLKDPNHIVGNGPGIIQIARGNSKYYDDTAGGYIDHAELSASADGDRGEYKFSYSIKGQSRSGKTLVWALPHHQEVITNVKPTDLNLDSPTKGVMKSYVTNELVMQEQLPVDIMWDPWATFATKAKYSNNAKEIIKQAAIEEVKQDVVGMADIDSMYTSGKILDKFAHIAYVCHFILQDESLTNEVVPKLKQAIEIFARNKQKFPLVYDCSWKGLISSAEPGADFGNSNYNDHHFHYGYHVHAIAILSHIDQDWLHANNDLIFNYANTLIRDIASPQADQYFPQFRSFDFFHGHSWAHGIFPSGDGKDNESSSEMYHFARAIKLYGNVIGDKNMQHRGDLMLAIMKRSVNMYMLYTRDNKIQPPNFIGNKVSGILFENKIDYATYFGRGTIGDEWIHGIHMLPITPVSSYFRSSKFVKEEWDEKLGAIVDQIPDGWKGILMLNKALFDPKSAWDWFARKDWDPVLIDNGMSRTWSLAYIAGIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQK4</accession>
    <name>A0A1D8PQK4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C700230WA</name>
        <name evidence="10" type="ordered locus">orf19.7100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720391.1">
        <property type="nucleotide sequence ID" value="XM_715298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQK4"/>
    <dbReference type="SMR" id="A0A1D8PQK4"/>
    <dbReference type="FunCoup" id="A0A1D8PQK4">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQK4"/>
    <dbReference type="GeneID" id="3637982"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700230WA"/>
    <dbReference type="CGD" id="CAL0000174737">
        <property type="gene designation" value="orf19.7100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00230W_A"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQK4"/>
    <dbReference type="OMA" id="MKWTHIA"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015188">
        <property type="term" value="F:L-isoleucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090513">
        <property type="term" value="P:L-histidine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="192"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000174737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW30402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="588" mass="64429" checksum="BCC4DBF18DE11950" modified="2017-01-18" version="1">MIEEDENTSLLSRRPSHSFLDTPIGSFKGPNSLHNFASSFTRAQSFAANKIDNSIHKKRSFFVSGDGGTVEDDETFDPELLVPSYRGERLSTVMHDIQSRNQLFMNPPNQLDQSVSPNNDVFFHDDVMNALNESRSRQNSTFGNSQFKHRIYSAPSFSSFRSSISAATTPSIFQVRKIEDEDGNVVTVLAGQSTAPQTIFNSVNVLIGVGLLALPVGLMKAGWVYGIPILLVCGLTTYWTACLLSKAMDTDDTIMTYADLGYAAYGSMAKLVISVLFSIDLLGAGVSLIVLFSDSLYALLGDDQVWTRTRFKILSFIVLTPFTFVPLPILSIISLFGILSTISITILVMVCGLLKPTAPGSLLETMPTNLYPKSLPDLLLAIGILMAPFGGHAIFPNLKSDMRHPYKFTQTLRSTYSITLLTDCSMAVLGFLMFGQNCSNEVTNTLLTTAGYPKWCYPLISGLICLVPLAKTPLNAKPIISTLDVLFGVANISTNKIRETVNSLGRFVIRIGVNAVFVVLAILFPEFDKIIGMLGASICFIICIILPCLFYVRLCGSKIRGFERFMVYSAIFISCVLASAATWAVLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQQ3</accession>
    <name>A0A1D8PQQ3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">GPH1</name>
        <name evidence="12" type="ordered locus">CAALFM_C700930WA</name>
        <name evidence="11" type="ordered locus">orf19.7021</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720315.1">
        <property type="nucleotide sequence ID" value="XM_715222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQQ3"/>
    <dbReference type="SMR" id="A0A1D8PQQ3"/>
    <dbReference type="FunCoup" id="A0A1D8PQQ3">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQQ3"/>
    <dbReference type="GeneID" id="3637956"/>
    <dbReference type="KEGG" id="cal:CAALFM_C700930WA"/>
    <dbReference type="CGD" id="CAL0000189831">
        <property type="gene designation" value="GPH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_00930W_A"/>
    <dbReference type="eggNOG" id="KOG2099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQQ3"/>
    <dbReference type="OMA" id="WLKQANP"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000189831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW30468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="900" mass="102857" checksum="43B1477D6E62F5E0" modified="2017-01-18" version="1">MPMDYLTPSTLPHPKLKRTNTGFTPNQIIALDAAIPESAKHIWYKYSQLKILDSHKRNGPEDEDNVKSVVDDPDRFEEEFVKHVETSLGRSMYNCDNLAAYQAASNTIRDALVIDWANTQQRQTIQDGKRVYYLSLEFLMGRAMDNALINLNSEQNTQKSLSDLGFNLEDVLDQEPDAALGNGGLGRLAACFVDSLSSKNYSGWGYGLNYQYGIFKQKIIDGYQIETPDYWLNYSNPWVIDRNEIQIPVDFYGYVYEEHDPNTGKVKKNWNGGERVLAVAADFPIPGFNTTNTNNLRLWNAKPTTEFDFSKFNAGDYQQSVAAQQRAESITSVLYPNDNFEKGKELRLKQQYFWVAASLHDIVRRFKKNHKSNWQKFPDQVAIQLNDTHPTLAVVELQRILVDLEGLDWDEAWSIVTKVFAYTNHTVMAEALEKWPVDLVGRLLPRHLEIIYDINYFFLKNVEHRYPNDRDLLRRVSIIEESPKSVRMAYLAIVGSHKVNGVAELHSELIKTTIFKDFVKVFGPDKFTNVTNGITPRRWLRQANPKLAALIAEKLEDPNYDYLTNLGKLKKLEAFVDDYEFLKRWDAIKFDNKRRLATLIKETTDVDVDPTVLFDVQVKRIHEYKRQQLNIFAVIYRYLHIKELLSKGVSIEEIKTKHHIPKASIFGGKAAPGYYMAKTIIHLINKVGDVINNDPEIGNLLKVVFIPDYNVSKAEIICPGSDLSNHISTAGTEASGTSNMKFALNGGLIIGTVDGANVEITREIGEENIFLFGNLAESVEEIRHRHVYEGVKVPESLQKVFHAIESGDFGSPEEFKPLIESIRDHGDYYLVTDDFDLFLEAHKKLEKVYGHHGGDEHDKSHMNEWVKKSVLSVANMGFFSSDRCIDEYAENIWNVEPSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQX5</accession>
    <name>A0A1D8PQX5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C701690WA</name>
        <name evidence="6" type="ordered locus">orf19.13908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721391.2">
        <property type="nucleotide sequence ID" value="XM_716298.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQX5"/>
    <dbReference type="FunCoup" id="A0A1D8PQX5">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQX5"/>
    <dbReference type="GeneID" id="3636980"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701690WA"/>
    <dbReference type="CGD" id="CAL0000199667">
        <property type="gene designation" value="orf19.13908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01690W_A"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQX5"/>
    <dbReference type="OMA" id="ETRCAHY"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016694">
        <property type="entry name" value="UCP017292"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF1">
        <property type="entry name" value="HELPER OF TIM PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017292">
        <property type="entry name" value="UCP017292_Znf_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000199667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW30535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="118" mass="13621" checksum="3665E5D9D4A4AC69" modified="2017-01-18" version="1">MTKSEFQIQKISPNISLIGQLVDNHTRCTHYHTKLDIIAIKFKCCNNYYPCFKCHQESTNHEPDRFDKNDNTTKAVLCGNCVNELTVTEYLNCGYTCTYCGGQFNPGCSLHYEIYFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRZ8</accession>
    <name>A0A1D8PRZ8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">PTC2</name>
        <name evidence="14" type="ordered locus">CAALFM_CR01520WA</name>
        <name evidence="13" type="ordered locus">orf19.10072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718206.2">
        <property type="nucleotide sequence ID" value="XM_713113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRZ8"/>
    <dbReference type="SMR" id="A0A1D8PRZ8"/>
    <dbReference type="FunCoup" id="A0A1D8PRZ8">
        <property type="interactions" value="1486"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PRZ8"/>
    <dbReference type="GeneID" id="3640105"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01520WA"/>
    <dbReference type="CGD" id="CAL0000180955">
        <property type="gene designation" value="PTC2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01520W_A"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRZ8"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="PHI-base" id="PHI:9542"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="340" mass="38470" checksum="EF742C629DDCB7E3" modified="2017-01-18" version="1">MEESRKNGTIHETQPPQNKRDKKRTNIAGRLNKLELTFKNDRDMFYRNSLHELQNKLATLQQGSNEEFLYKKMNLEEVRDYELTKLRLWEEYQVKRIESEYQEDLNRAKEQHDKMIKLIKEKLYDKLQQQIKHLKEDKFLVNLVNGKSWMNPEDPTNQAFNSVAIAELNANDRRSLRKRELAGRFSVGEAADLSDGGGGSGVGGGSADNFSSVYNNGGYSSAGKRRRIYATRYSSNDELSSGTTSGMPLNNHSSTRQNGNATSGYESNLSDKDYDTLNVLIMENEDGGASLNLTAKNGGVSQHKVQTRGSNKHFVGPQGLKPEELNEDLTLLRNAIVKKD</sequence>
</entry>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="91563" checksum="F355B35BD7B4E9E8" modified="2017-01-18" version="1">MYFPIIVWLYVSITFVVANYGFDQWTNDDLKQFLKERKVAFNDALENPKLISLANEEAKKLEKGYKKVTEELNNNLNPPDDSLNDYLNFDYLFGKRKENYSIKEWIFESWPVTSLQTFLTQNNIQYSAKDTKDDLINKVKDQFDSISKKNHGSSFYPGNWLYESWSENDLKDWLKSYGIEFNPSSTKDQLVEKLKEFSYQATHSIRDSKESLFDSLDLFDKTIFDKKGQIEDEFFQTWSYSQLREWLYLHGFIDTKPGIYVEDLDKEKLVKIAQSYKKCLLSDIHTWLANTEKKSQPWITKGEQKSQKKKGSNLINDTFFVGINNWSKDKLREFLDVRKVPYSIFTTKHQLIKLVQKHKFDPVHVETYAWIVDDVSTDSIKQWLIEQGENVEGTRKDIVSAFQKQFESLKKGFKDAFNNVDSQIRLFAPDINGYKRYLQKKLSEAEYKKLTEDQISQGFKVVQEYYNSAGDAAKEEFTKTTYSAEEALDQIEEASYEYSLEFLRKLEKGEHDVTSFIKDARVASKSFALSLITKLRENAQKLQTDALNKVGSWWYGAKSGFSNKVDEAHQVVLDVHDQAVNYQEQVGSQYSSIKAEADEKYDSIAKEATQQYDTAVQNAQEQYKQAQEHVSKFADDVGSQATQTHKKLEKDYVTYKSKIFSFLTNVYRGIMYRLSIFNSNAYDAAKSTGDVINNQWNSVVRTYSNADLKAYLRSFGYSYDWLSALNRRELLSLATFQNKLFSGYDNLQNWEKSVGEVLNDASDELKIKLGLKKEPKSLIAKLKSVVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU03</accession>
    <name>A0A1D8PU03_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">WAL1</name>
        <name evidence="6" type="ordered locus">CAALFM_CR09650WA</name>
        <name evidence="5" type="ordered locus">orf19.6598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711299.2">
        <property type="nucleotide sequence ID" value="XM_706207.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU03"/>
    <dbReference type="SMR" id="A0A1D8PU03"/>
    <dbReference type="FunCoup" id="A0A1D8PU03">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PU03"/>
    <dbReference type="GeneID" id="3647093"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09650WA"/>
    <dbReference type="CGD" id="CAL0000197581">
        <property type="gene designation" value="WAL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09650W_A"/>
    <dbReference type="eggNOG" id="KOG3671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU03"/>
    <dbReference type="OMA" id="EYNQDRK"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="C:SLAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000197581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="713" mass="76851" checksum="A9851FBADD363F5D" modified="2017-01-18" version="1">MGILTTQDKEKVKRAIPKANNKIIDATVARLYIAYPDPTKWAYTGLVGAIALVDDLVGHTFFLKLVDIIGHRGVVWDQELYVNFEYNQDRKYFHTFEIEECFVGLLFEDTNDATHFYKRVTTRQKYGSSATVKNKSAIALKERIGSNKSYEIPGPRGEFMDVNTAQRQRRAKGVLYYDDVPPPEWRSLYAELEAAGITEDMIADNRQFIKDYISQQGGPLVGLEPPIPRKFQRKHEIEHSMAIAEPLTVSISSSSSNTTSKHKKAPPPPPPPPPSGPTSQQQQQQQQQSTTVDHHYPSNESKEPSYSPSPSPTSTSTSTPEPESHEITPAKPRFRLPPSTAIAPPVRNTSLPPNGPQFIDKPLPKVPLPLSPVSPQAPNHAYPTTTNTNTNTNTPFNHSVHQVPPPPPARATPPAPPPRARTNQLGLPPRNTPGLPPRTNNTQPPPAPPPRASRGAVPPPPPPPPRATRAPMQLQLQSSPQSSPISPPAQQQQQQQYPSIPPRENTSAIISSPPPAPPLPQQPRPTIATPQQQQQQLPQATTSSVASPAPPLPPQMNQTTQQTPATTTTTTTTTTPSIPAPPPPPPAPPMPDMSNDTSTSANTGGGISEATGDAGRDALLASIRGAGIGVLKKTDKSQLEKPSILLQEAKGETPQINSNTGTSSNAPPATLADAPPATLADAPPATLADALASALNKRKEKVAQSDDEEDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU32</accession>
    <name>A0A1D8PU32_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_CR09990WA</name>
        <name evidence="5" type="ordered locus">orf19.7574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719336.1">
        <property type="nucleotide sequence ID" value="XM_714243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PU32"/>
    <dbReference type="SMR" id="A0A1D8PU32"/>
    <dbReference type="STRING" id="237561.A0A1D8PU32"/>
    <dbReference type="GeneID" id="3638930"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09990WA"/>
    <dbReference type="CGD" id="CAL0000176188">
        <property type="gene designation" value="orf19.7574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09990W_A"/>
    <dbReference type="eggNOG" id="KOG0783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PU32"/>
    <dbReference type="OMA" id="FEFVLRY"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="865"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1404"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1404"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1416"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000176188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW31654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1439" mass="163391" checksum="19F0A216F046B024" modified="2017-01-18" version="1">MNSIDVTKLKKLAKDDLFKRDIFGRTILHICILVNNSDALKSLTKNPDFKTLLKLNDYENGWNCLHYIFFHKRLQCLKVLIDYLQGTIVQGNIFATNSPLLELLKFKDRNGHTPLNLLNNDFKDLLWFPEYITDKNEFHMTYKYERIKSTKDVVQPEYEPDTLPFLKSSEILWTDKRGASEIYVFGCNSNNQLGVGDSTDRATPALLYHDNFKFATDLTGSISERFKRPRYKRITISKNHSVVVTQDGELFSCGVGSRGRLGHGLTDLNNYFKFKRIEFFNDKTIKDVAISSNHSIALTTDNEVYAWGLNSFNQLGVPNMNNKKSTNYLDKFIATPIMVGGELRKMQNIIGIEVSKIHSLAWSKNYLCFWGLNVGQMGISYTNGDIEVKVQERSVRGETQVNPKAIQLRDDIKCVSTSELCTCVVTTLNDVHVYYNYQHFKLPKIPMKGHGDKHFDYFKPRRITEAAVIKKIVTRGPENSMILLKNGSVFSFSVNANDIKNTKYTSIWKAYDHDMVATDIDISTDGSVVLCTRSGTVFIKSTLSSNQRKNSMSGATLPIPLTKNKFKKIENVNNVVRVTCDPKFLSFGFMRDDIDLLPLELPQNDFFTDIETLSPAVEYNFNRKQNKLFDTQDHLYIANFFTASRNNTHEDDADDAEYDKLYSNQDASVINKIEEIYNSKFDPRASKRVKALSTYENIVSEEVYSTIKRCSGYGEDYVDGLKDILSNNENLFDANFEFAFAQDAKFGFHSRVLEFRSSVFQKLLQLNDKNETLIGDNIKIVWIPEQSTLRVLTTISPVAALMFMHSVYSGRKMDNLEQNVFSYSSPELVRLRINQYQSLCSLFGIGCDRLSVTDAFQDLLNSNTGDVVIKASDGDVFAHAFVLKARSAFFETLLSERWDTEEKGNVQYVDFTGLTKFQVTLILRHLYGVSNESLLDCFQYDFGEKDYFINDLLELIEVADELLLFQLKSVLQLAICDMISLDNVLVLLVHGFTLNARQLFLNCCWYIFNNLEVLMFAPGFKEIPNETMQLLEVFIDKLGNVQNGTKNWIDQNPNILLEHIENIEEFNEYFMSDRKGFSSFKPLIDNGYIDAIKTKETVKKRKSRKSSTSAFNKDISDFRQGLRRENNGESFPPTIIDENDGFILVENKTKQRNASSSSPNILNMNGIVEPTNKIGNLSVIGKLTSIHPNPESFVQSSGLPSTSNWATKPQSSSIESNTLLPAAISTTLTTAKSKPTKVKIGPVTKLSQKQRKRLAAAAANDANLEQIDQKTTKESSTIAPWSTCVADTPISNSQNINNLPALGSSKPKKKFISISRPQSTKKSPSLISIPSSTASTPFSMAAAITPDSSFNSVYSTPSLTEVMIHESLKLEQAKLQETERKTLVEIQQEQEFAKWWEEESKRVQEEMQRLEVADTKKKKKKKNTSPKPQKYRKPIKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PU42</accession>
    <name>A0A1D8PU42_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_CR10120CA</name>
        <name evidence="5" type="ordered locus">orf19.7588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="273" mass="31320" checksum="8C36F407062B06D7" modified="2017-01-18" version="1">MISILRQPIYIILNNSLSTTSLRGLKFSAIQDCQQYLSYCSKNSINTGSTVFRGTLYELHVKAFFEKYLNCENLIKNGGAYDNGVDIIGKWNLSPFYNEQEREYEYDTKPIKLSSKSILKYSQESKFNIASNPISLINDIQVLIQCKNVKKKPDAKIIRELSGILDFHKFNKKSTFMFIVTPYPCTPQAVVQLDTTNHAIIHFMISPLTNNSVKITRNQDNDDNDNDYSGDSFFNLDSWKGGDLKLVYMNRQARKLLSGLNMEQKLKLISFID</sequence>
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    <name>A0A1D8PU55_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
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        <name evidence="4" type="ordered locus">CAALFM_CR10230WA</name>
        <name evidence="3" type="ordered locus">orf19.7598</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719360.1">
        <property type="nucleotide sequence ID" value="XM_714267.1"/>
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    <dbReference type="SMR" id="A0A1D8PU55"/>
    <dbReference type="STRING" id="237561.A0A1D8PU55"/>
    <dbReference type="GeneID" id="3638921"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10230WA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CR_10230W_A"/>
    <dbReference type="eggNOG" id="ENOG502S5YH">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome R"/>
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    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
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    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="439"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="167"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000190603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW31673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="439" mass="48989" checksum="DB09277AC933B3DB" modified="2017-01-18" version="1">MSSDQFELSDDTKPEVPNTFPIEDEQSQQQDASKSRDFPTESAKETIINRLRNIPHEELKEILTNQLDLEIQLKHRELNISDNEIGKIESQMLMLRKFFDIPNDKKLNNEPTDFTTKYFDILQKSLTSTYDNFKQLPEAPPQLNPSYLDGNKSGASPVSQPVHSYRTRSTTSSLRPSATSIASGIRNPSLGCLYRRTDGVVVRLTCPNCQRSNFSSAQGFLNHSRIAHSKEYTSQDAAALKCGDILPEIKQDLTGEASIKMLVERGLDPTRNLNVNEFLFGRINTATTSTGEQNSATDGSSTMNLSSSNARKLEGKRDSGGSGGDNNEQLTQPQPITTSPTIEPSNELMKKLIKEGTMNKEEYEKLLKETKEPTSNSHLFDDETEEVGDSEESSLSTTPSCSKSVSLNDRKRRQSRGGINISISKDMEVHEPEEKKLKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-08-01" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>P22011</accession>
    <accession>A0A1D8PR38</accession>
    <accession>Q3MPA6</accession>
    <accession>Q5AH66</accession>
    <name>PPIA_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName>PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cyclophilin</fullName>
            <shortName>CPH</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Cyclosporin A-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CYP1</name>
        <name type="ordered locus">CAALFM_C702380CA</name>
        <name type="ORF">CaJ7.0279</name>
        <name type="ORF">CaO19.13826</name>
        <name type="ORF">CaO19.6472</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Gene" volume="96" first="189" last="195">
            <title>A Candida albicans homolog of a human cyclophilin gene encodes a peptidyl-prolyl cis-trans isomerase.</title>
            <authorList>
                <person name="Koser P.L."/>
                <person name="Livi G.P."/>
                <person name="Levy M.A."/>
                <person name="Rosenberg M."/>
                <person name="Bergsma D.J."/>
            </authorList>
            <dbReference type="PubMed" id="2269432"/>
            <dbReference type="DOI" id="10.1016/0378-1119(90)90252-M"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Genetics" volume="170" first="1525" last="1537">
            <title>Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.</title>
            <authorList>
                <person name="Chibana H."/>
                <person name="Oka N."/>
                <person name="Nakayama H."/>
                <person name="Aoyama T."/>
                <person name="Magee B.B."/>
                <person name="Magee P.T."/>
                <person name="Mikami Y."/>
            </authorList>
            <dbReference type="PubMed" id="15937140"/>
            <dbReference type="DOI" id="10.1534/genetics.104.034652"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="M60628">
        <property type="protein sequence ID" value="AAA34336.1"/>
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        <property type="protein sequence ID" value="BAE44754.1"/>
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        <property type="protein sequence ID" value="AOW30599.1"/>
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    <dbReference type="RefSeq" id="XP_721313.1">
        <property type="nucleotide sequence ID" value="XM_716220.2"/>
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        <property type="interactions" value="1"/>
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    <dbReference type="Allergome" id="799">
        <property type="allergen name" value="Cand a CyP"/>
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    <dbReference type="EnsemblFungi" id="C7_02380C_A-T">
        <property type="protein sequence ID" value="C7_02380C_A-T-p1"/>
        <property type="gene ID" value="C7_02380C_A"/>
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    <dbReference type="GeneID" id="3636978"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702380CA"/>
    <dbReference type="CGD" id="CAL0000183095">
        <property type="gene designation" value="CYP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02380C_A"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="InParanoid" id="P22011"/>
    <dbReference type="OMA" id="FKSIVPR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:cyclosporin A binding"/>
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    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
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    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
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    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
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    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
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    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000064129" description="Peptidyl-prolyl cis-trans isomerase">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="2269432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="162" mass="17575" checksum="3467726615CDB50D" modified="1991-08-01" version="1">MSTVYFDVSADGQKLGKITFKLYDDVVPKTAENFRALCTGEKGFGYKGSIFHRVIPQFMLQGGDFTNFNGTGGKSIYGTKFADENFVKRHDRPGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVTDGLDIVKKIESFGSGSGATSKKIVIEESGQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>P41797</accession>
    <accession>A0A1D8PFP4</accession>
    <accession>Q5AKZ7</accession>
    <name>HSP71_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Heat shock protein HSP70</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">SSA subfamily protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HSP70</name>
        <name evidence="15" type="synonym">HS71</name>
        <name evidence="15" type="synonym">SSA1</name>
        <name evidence="16" type="synonym">SSA4</name>
        <name type="ordered locus">CAALFM_C113480WA</name>
        <name type="ORF">CaO19.12447</name>
        <name type="ORF">CaO19.4980</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Infect. Immun." volume="63" first="4039" last="4045">
            <title>Molecular cloning and expression of a 70-kilodalton heat shock protein of Candida albicans.</title>
            <authorList>
                <person name="La Valle R."/>
                <person name="Bromuro C."/>
                <person name="Ranucci L."/>
                <person name="Muller H.M."/>
                <person name="Crisanti A."/>
                <person name="Cassone A."/>
            </authorList>
            <dbReference type="PubMed" id="7558317"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>INDUCTION</scope>
        <scope>FUNCTION AS AN ANTIGEN</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1995" name="FEMS Microbiol. Lett." volume="128" first="95" last="100">
            <title>Cloning of a DNA fragment encoding part of a 70-kDa heat shock protein of Candida albicans.</title>
            <authorList>
                <person name="Eroles P."/>
                <person name="Sentandreu M."/>
                <person name="Elorza M.V."/>
                <person name="Sentandreu R."/>
            </authorList>
            <dbReference type="PubMed" id="7744244"/>
            <dbReference type="DOI" id="10.1016/0378-1097(95)00089-N"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] OF 1-244</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1996" name="Infect. Immun." volume="64" first="3333" last="3340">
            <title>Evidence for presence in the cell wall of Candida albicans of a protein related to the hsp70 family.</title>
            <authorList>
                <person name="Lopez-Ribot J.L."/>
                <person name="Alloush H.M."/>
                <person name="Masten B.J."/>
                <person name="Chaffin W.L."/>
            </authorList>
            <dbReference type="PubMed" id="8757872"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="20438" last="20447">
            <title>Candidacidal activity of salivary histatins. Identification of a histatin 5-binding protein on Candida albicans.</title>
            <authorList>
                <person name="Edgerton M."/>
                <person name="Koshlukova S.E."/>
                <person name="Lo T.E."/>
                <person name="Chrzan B.G."/>
                <person name="Straubinger R.M."/>
                <person name="Raj P.A."/>
            </authorList>
            <dbReference type="PubMed" id="9685398"/>
            <dbReference type="DOI" id="10.1074/jbc.273.32.20438"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HUMAN ANTIFUNGAL PEPTIDE HTS 5</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="Proteomics" volume="1" first="550" last="559">
            <title>Analysis of the serologic response to systemic Candida albicans infection in a murine model.</title>
            <authorList>
                <person name="Pitarch A."/>
                <person name="Diez-Orejas R."/>
                <person name="Molero G."/>
                <person name="Pardo M."/>
                <person name="Sanchez M."/>
                <person name="Gil C."/>
                <person name="Nombela C."/>
            </authorList>
            <dbReference type="PubMed" id="11681208"/>
            <dbReference type="DOI" id="10.1002/1615-9861(200104)1:4&lt;550::AID-PROT550&gt;3.3.CO;2-N"/>
        </citation>
        <scope>FUNCTION AS AN ANTIGEN</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2002" name="Med. Mycol." volume="40" first="471" last="478">
            <title>Gene expression of 70 kDa heat shock protein of Candida albicans: transcriptional activation and response to heat shock.</title>
            <authorList>
                <person name="Sandini S."/>
                <person name="Melchionna R."/>
                <person name="Bromuro C."/>
                <person name="La Valle R."/>
            </authorList>
            <dbReference type="PubMed" id="12462526"/>
            <dbReference type="DOI" id="10.1080/mmy.40.5.471.478"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2003" name="FEBS Lett." volume="544" first="228" last="235">
            <title>Identification of cell surface determinants in Candida albicans reveals Tsa1p, a protein differentially localized in the cell.</title>
            <authorList>
                <person name="Urban C."/>
                <person name="Sohn K."/>
                <person name="Lottspeich F."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="12782322"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(03)00455-1"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="28553" last="28561">
            <title>Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5.</title>
            <authorList>
                <person name="Li X.S."/>
                <person name="Reddy M.S."/>
                <person name="Baev D."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="12761219"/>
            <dbReference type="DOI" id="10.1074/jbc.M300680200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HUMAN ANTIFUNGAL PEPTIDE HTS 5</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="584" last="589">
            <title>cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol.</title>
            <authorList>
                <person name="Cao Y.Y."/>
                <person name="Cao Y.B."/>
                <person name="Xu Z."/>
                <person name="Ying K."/>
                <person name="Li Y."/>
                <person name="Xie Y."/>
                <person name="Zhu Z.Y."/>
                <person name="Chen W.S."/>
                <person name="Jiang Y.Y."/>
            </authorList>
            <dbReference type="PubMed" id="15673737"/>
            <dbReference type="DOI" id="10.1128/AAC.49.2.584-589.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="2913" last="2925">
            <title>Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.</title>
            <authorList>
                <person name="Garcia-Sanchez S."/>
                <person name="Mavor A.L."/>
                <person name="Russell C.L."/>
                <person name="Argimon S."/>
                <person name="Dennison P."/>
                <person name="Enjalbert B."/>
                <person name="Brown A.J."/>
            </authorList>
            <dbReference type="PubMed" id="15814841"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-01-0071"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2006" name="J. Biol. Chem." volume="281" first="22453" last="22463">
            <title>Candida albicans cell wall ssa proteins bind and facilitate import of salivary histatin 5 required for toxicity.</title>
            <authorList>
                <person name="Li X.S."/>
                <person name="Sun J.N."/>
                <person name="Okamoto-Shibayama K."/>
                <person name="Edgerton M."/>
            </authorList>
            <dbReference type="PubMed" id="16720580"/>
            <dbReference type="DOI" id="10.1074/jbc.m604064200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH HUMAN ANTIFUNGAL PEPTIDE HTS 5</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2009" name="Antimicrob. Agents Chemother." volume="53" first="2392" last="2401">
            <title>Farnesol-induced apoptosis in Candida albicans.</title>
            <authorList>
                <person name="Shirtliff M.E."/>
                <person name="Krom B.P."/>
                <person name="Meijering R.A."/>
                <person name="Peters B.M."/>
                <person name="Zhu J."/>
                <person name="Scheper M.A."/>
                <person name="Harris M.L."/>
                <person name="Jabra-Rizk M.A."/>
            </authorList>
            <dbReference type="PubMed" id="19364863"/>
            <dbReference type="DOI" id="10.1128/AAC.01551-08"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="16">
        <citation type="journal article" date="2010" name="Antimicrob. Agents Chemother." volume="54" first="1655" last="1664">
            <title>Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents.</title>
            <authorList>
                <person name="Hoehamer C.F."/>
                <person name="Cummings E.D."/>
                <person name="Hilliard G.M."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="20145080"/>
            <dbReference type="DOI" id="10.1128/aac.00756-09"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Heat shock protein that may play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.</text>
    </comment>
    <comment type="function">
        <text evidence="3 5 9 12 14">Acts as a highly immunodominant antigen (PubMed:11681208, PubMed:7558317). HSP70/SSA1 and SSA2 bind histatin-5, a peptide from human saliva, and mediates its fungicidal activity (PubMed:12761219, PubMed:16720580, PubMed:9685398). SSA2 facilitates fungicidal activity of Hst 5 in binding and intracellular translocation, whereas HSP70/SSA1 appears to have a lesser functional role in Hst 5 toxicity (PubMed:16720580).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 9 14">Binds human histatin-5, an antifungal peptide from saliva.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6 9 13">Secreted</location>
            <location evidence="5 6 9 13">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 7 8 10 11 12">Induced by heat schock (PubMed:12462526, PubMed:7558317). The promoter contains at least three heat shock elements (HSEs) that are bound by the heat shock transcription factor (HSF), and one stress response element (STRE), which is an upstream activator sequence (UAS) that causes transcription activation under stress (PubMed:12462526). Expression in repressed by SSN6 (PubMed:15814841). Expression decreases after exposure to ketoconazole (PubMed:20145080). Expression is also affected by farnesol (PubMed:15673737, PubMed:19364863).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="9">Does not affect cells growth and hyphal formation (PubMed:16720580). Does not lead to any significant reduction in killing by Hst 5 (PubMed:16720580).</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="S78163">
        <property type="protein sequence ID" value="AAB34280.1"/>
        <property type="molecule type" value="mRNA"/>
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    <dbReference type="EMBL" id="CP017623">
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        <property type="gene ID" value="C1_13480W_A"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
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        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
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    </dbReference>
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        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000078364" description="Heat shock protein HSP70">
        <location>
            <begin position="2"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylserine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; AAB34280." evidence="18" ref="5">
        <original>A</original>
        <variation>G</variation>
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P10591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="12462526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12761219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="12782322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15673737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="15814841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="16720580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="19364863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="20145080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="7558317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="8757872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="9685398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="15">
        <source>
            <dbReference type="PubMed" id="11681208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="16">
        <source>
            <dbReference type="PubMed" id="15814841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="17">
        <source>
            <dbReference type="PubMed" id="7558317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="18"/>
    <sequence length="656" mass="70324" checksum="562BA08EDDFE2EFD" modified="2007-01-23" version="2">MSKAVGIDLGTTYSCVAHFANDRVEIIANDQGNRTTPSFVAFTDTERLIGDAAKNQAAMNPANTVFDAKRLIGRKFDDPEVINDAKHFPFKVIDKAGKPVIQVEYKGETKTFSPEEISSMVLTKMKEIAEGYLGSTVKDAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKGSRGEHNVLIFDLGGGTFDVSLLAIDEGIFEVKATAGDTHLGGEDFDNRLVNFFIQEFKRKNKKDISTNQRALRRLRTACERAKRTLSSSAQTSIEIDSLYEGIDFYTSITRARFEELCADLFRSTLDPVGKVLADAKIDKSQVEEIVLVGGSTRIPKIQKLVSDFFNGKELNKSINPDEAVAYGAAVQAAILTGDTSSKTQDILLLDVAPLSLGIETAGGIMTKLIPRNSTIPTKKSETFSTYADNQPGVLIQVFEGERAKTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDKMVSEAEKFKEEDEKEAARVQAKNQLESYAYSLKNTINDGEMKDKIGADDKEKLTKAIDETISWLDASQAASTEEYEDKRKELESVANPIISGAYGAAGGAPGGAGGFPGAGGFPGGAPGAGGPGGATGGESSGPTVEEVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-06-18" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>P87206</accession>
    <accession>A0A1D8PCG1</accession>
    <accession>Q5A910</accession>
    <name>IF4A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Eukaryotic initiation factor 4A</fullName>
            <shortName>eIF-4A</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TIF1</name>
        <name type="synonym">TIF</name>
        <name type="synonym">TIF41</name>
        <name type="ordered locus">CAALFM_C101350CA</name>
        <name type="ORF">CaO19.10834</name>
        <name type="ORF">CaO19.3324</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Med. Vet. Mycol." volume="34" first="393" last="400">
            <title>Molecular cloning of a gene encoding translation initiation factor (TIF) from Candida albicans.</title>
            <authorList>
                <person name="Mirbod F."/>
                <person name="Nakashima S."/>
                <person name="Kitajima Y."/>
                <person name="Ghannoum M.A."/>
                <person name="Cannon R.D."/>
                <person name="Nozawa Y."/>
            </authorList>
            <dbReference type="PubMed" id="8971628"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="D84472">
        <property type="protein sequence ID" value="BAA20371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718147.1">
        <property type="nucleotide sequence ID" value="XM_713054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P87206"/>
    <dbReference type="SMR" id="P87206"/>
    <dbReference type="BioGRID" id="1223011">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="FunCoup" id="P87206">
        <property type="interactions" value="1360"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P87206"/>
    <dbReference type="EnsemblFungi" id="C1_01350C_A-T">
        <property type="protein sequence ID" value="C1_01350C_A-T-p1"/>
        <property type="gene ID" value="C1_01350C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640190"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101350CA"/>
    <dbReference type="CGD" id="CAL0000186279">
        <property type="gene designation" value="TIF"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01350C_A"/>
    <dbReference type="eggNOG" id="KOG0327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="P87206"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PRO" id="PR:P87206"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000054965" description="ATP-dependent RNA helicase eIF4A">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="397" mass="44599" checksum="A81935EA752DDD60" modified="1997-07-01" version="1">MASEGITEIDSGLIETNYDNVVYKFDDLNLKPNIVRGIFGYGYETPSAIQQRAILPITEGRDVLAQAQSGTGKTATFTISALQRINENEKATQALILAPTRELALQIKNVITAIGLYLKVTVHASIGGTSMSDDIEAFRSGVQIVVGTPGRVLDMIERRYFKTDKVKMFILDEADEMLSSGFKEQIYNIFRLLPETTQIVLLSATMPQDVLEVTTKFMNNPVRILVKKDELTLEGIKQFYINVELEDYKFDCLCDLYDSISVTQAVIFCNTRSKVEFLTNKLREQHFTVSAIHADLPQAERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTDRDVGMMREIEKFYSTQIEEMPADIGALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q59KQ1</accession>
    <name>Q59KQ1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">GUT1</name>
        <name evidence="15" type="ordered locus">CAALFM_CR05220CA</name>
        <name evidence="14" type="ordered locus">orf19.8193</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710317.1">
        <property type="nucleotide sequence ID" value="XM_705225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59KQ1"/>
    <dbReference type="SMR" id="Q59KQ1"/>
    <dbReference type="FunCoup" id="Q59KQ1">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59KQ1"/>
    <dbReference type="GeneID" id="3648082"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05220CA"/>
    <dbReference type="CGD" id="CAL0000201946">
        <property type="gene designation" value="GUT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05220C_A"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_2_1"/>
    <dbReference type="InParanoid" id="Q59KQ1"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="93"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="357"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000201946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW31250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="631" mass="69212" checksum="868D73D48AF791B9" modified="2005-04-26" version="1">MPRRVSNAPCIPVVATIDIGTTSARAIIFSAEGEEIAKHQIEYSTTASEAPENSSNTDQFRRRSSLLRHDEPIFSAEGIAITLNDNIMIENNKSSVGPTIRFPQPGWVECMPVHILANAVQCLVACLISLRKVNQDPNLKLKYKVKAIGIANMRETTIVWSRKTGKPLSGGITWTDTRTSEIIQHLEKMIDEDRKAELKEKTGLPLSTYFSAAKLRWLLDNDDVIREEYEKGDGNLMFGTVDTWLIYHLTKEKAFVSDITNASRTYFMDLETLDYDDDLLDFWGIDPTKIRMPKIVSSSEFYGEFAAPKLDNLGFHNKITKEAYDILKTITGVPICGCLGDQSASLVGQLAFSAGSAKCTYGTGAFLLYNTGPHKLISKRGALTTFGFWFPTLKGTDGKPHYAMEGSIAVAGSIIQWLRDNLKMIDNAKDIGPLASQVENSGGVVFIPAFSGLYAPYWDGGSRGTIFGMTQYTSAAHIAHAALEGVCYQVRAILKAMASDAGAVDDFLEDALSCQNTDKLLSTLATDGGMSKADEVLQIQADILGPCVTVKRAQTAECTALGAAIAAGLSFKNEEDRIWKDLDDVVAKISGSSEDVAANSFTAKLSDENRRKAWKRWEKAVDRAKGWLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q59NB3</accession>
    <name>Q59NB3_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Snl1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">SNL1</name>
        <name evidence="4" type="ordered locus">CAALFM_C110530WA</name>
        <name evidence="3" type="ordered locus">orf19.8612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711215.1">
        <property type="nucleotide sequence ID" value="XM_706123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59NB3"/>
    <dbReference type="SMR" id="Q59NB3"/>
    <dbReference type="STRING" id="237561.Q59NB3"/>
    <dbReference type="GeneID" id="3647192"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110530WA"/>
    <dbReference type="CGD" id="CAL0000179145">
        <property type="gene designation" value="SNL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10530W_A"/>
    <dbReference type="eggNOG" id="ENOG502S9TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372014_0_0_1"/>
    <dbReference type="InParanoid" id="Q59NB3"/>
    <dbReference type="OMA" id="YNYFEEM"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000179145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="199" mass="23489" checksum="FE90530F32E013C3" modified="2005-04-26" version="1">MEKVTEHLNEFKSKIPNSVEELQDYLDYLKEKIPTSYDDFKPQIEYVKSIKGEDVVNDFKNLKVSPITVSLTLVAFTTLYLFGKLIGGGRAEETPKKKPRKKLTKAQKANRQIQEILDYVESTYVPEIDKFIETYKELSSEDVEYKFNYFEEMLLKELMKLDAIDVTSNEILRDNRRKVIKFIQDHQKRLDKFKKEIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q59PD9</accession>
    <name>Q59PD9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C112690CA</name>
        <name evidence="1" type="ordered locus">orf19.13711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711572.1">
        <property type="nucleotide sequence ID" value="XM_706480.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59PD9"/>
    <dbReference type="GeneID" id="3646832"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112690CA"/>
    <dbReference type="CGD" id="CAL0000191895">
        <property type="gene designation" value="orf19.13711"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12690C_A"/>
    <dbReference type="eggNOG" id="ENOG502RQ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111193_0_0_1"/>
    <dbReference type="InParanoid" id="Q59PD9"/>
    <dbReference type="OrthoDB" id="4084909at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000191895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW26884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="216" mass="25217" checksum="2166AC885CF2CEA3" modified="2005-04-26" version="1">MVDNTFEGLFKRINDLELILLDDNNNKVNNIGDHNDDKTISSQINQLKSQLSKLYQQYPEFQKLNNINSQLKIWNKLHLNTSTATTTTTTTPIDKETKLEFLNLLYDDLINTDNYEKMISIINFQYESIINGINNNYLLSSGSINDTSELLAKRKQLNQIMKIHQALIIKSMIVLERYIQCTIRQNKFWIDIDDQLVKINAKIKQLELSKLQANKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Q77</accession>
    <name>Q59Q77_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">REV1</name>
        <name evidence="20" type="ordered locus">CAALFM_C406020CA</name>
        <name evidence="19" type="ordered locus">orf19.11890</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QH2</accession>
    <name>Q59QH2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Csh1p</fullName>
        </submittedName>
    </protein>
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        <name evidence="3 4" type="primary">CSH1</name>
        <name evidence="4" type="ordered locus">CAALFM_C104020CA</name>
        <name evidence="3" type="ordered locus">orf19.4477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="gene designation" value="CSH1"/>
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        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
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        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="15"/>
            <end position="325"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000175449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="337" mass="38274" checksum="4931D76DFFA83F87" modified="2005-04-26" version="1">MVTRLGKSGLKVNTVAVGTMRLGSSWRGFNGDIDECLKILKFCYDNGFRTFDTADTYSNGKSEELLGLFIKKYNIPRERIVILTKCYFSVKDDAEDSSLEIDPIDYMNGKGLSRKHILAAAEASVKRLGTYIDVLQIHRLDHEVTYEEVMRSLNDVVEQGLARYIGASSMKTWEFVELQNVAKANGWHQFISMQSHYSLLYREDERELNDYCKKNSIGLIPWSPNGGGVLCRPFDSEKTKQFLDNKQWSSLFGLENVRDADKIIVDRVKELSVKYNASMMQVSLAWCISKGVIPIAGVSKFEQAEELVGIFKVNLTEDDIKYLEEPYHAKDLARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q59QN6</accession>
    <name>Q59QN6_CANAL</name>
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            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
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        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name evidence="10" type="ordered locus">CAALFM_CR05170CA</name>
        <name evidence="9" type="ordered locus">orf19.8252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711984.1">
        <property type="nucleotide sequence ID" value="XM_706891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59QN6"/>
    <dbReference type="SMR" id="Q59QN6"/>
    <dbReference type="FunCoup" id="Q59QN6">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59QN6"/>
    <dbReference type="GeneID" id="3646398"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR05170CA"/>
    <dbReference type="CGD" id="CAL0000180074">
        <property type="gene designation" value="FDH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_05170C_A"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_0_0_1"/>
    <dbReference type="InParanoid" id="Q59QN6"/>
    <dbReference type="OMA" id="HYTDRHR"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="CGD"/>
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    </dbReference>
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        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
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    </dbReference>
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        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="130"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="244"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000180074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="379" mass="41802" checksum="5478C8BAF309FE89" modified="2005-04-26" version="1">MGKPKVLMVLYAGGNHAKEETRLLGTVENELGIRKLVEEHGYELVTTTDKEPAPTSAFDENLEDAEIIITTPFFPAYVNKERIAKAPKLKLCITAGVGSDHYDLDALNERGIAAIEVTGSNVVSVAEHAVMTMLILIRNYGEGHAQATKGTWDVAAVAKDEFDLEDKVIATVGAGRIGYRILERLVAFNPKKLLYYDYQPLPEEAINKLNAASKLFNGVDNIVERVEKLEDLVSQADVVTINCPLYEKSRGLFNKDLISKMKKGSYLVNTARGAIVDPEAVADAVNSGHIAYGGDVWPVQPAPKDMPWRTMHNPYGEAYGNAMTLHVSGTSLDAQARYANGVKQILTEYFNKTYNYRPQDVIVIDGDYATKAYGQREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q59R27</accession>
    <accession>Q3MNZ6</accession>
    <name>Q59R27_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SDD3</name>
        <name evidence="7" type="ordered locus">CAALFM_C703610CA</name>
        <name evidence="6" type="ordered locus">orf19.13985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712146.1">
        <property type="nucleotide sequence ID" value="XM_707053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59R27"/>
    <dbReference type="SMR" id="Q59R27"/>
    <dbReference type="FunCoup" id="Q59R27">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59R27"/>
    <dbReference type="GeneID" id="3646241"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703610CA"/>
    <dbReference type="CGD" id="CAL0000177908">
        <property type="gene designation" value="SDD3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03610C_A"/>
    <dbReference type="eggNOG" id="KOG0961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006065_0_0_1"/>
    <dbReference type="InParanoid" id="Q59R27"/>
    <dbReference type="OMA" id="CVEGPFW"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000145">
        <property type="entry name" value="Uncharacterized protein CaJ7.0411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="4">
        <location>
            <begin position="133"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="5">
        <location>
            <begin position="272"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="807"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000177908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1143" mass="131527" checksum="E42F511F5B107D69" modified="2005-04-26" version="1">MHREFPPQNFICILTIWLLLYSCFFFLWSGKFFFTTLNKRFLILITTIHHHCQSPIISLFNRLIGKKLLDGVTHITMTKFNSPFIKQTSFEVDYAPTHITKWKSQRTGLQLTYINQPSPIVNGYFAVATEIFDSSGAPHTLEHLIFMGSKKFPYKGLLDNLGNRLYSSTNAWTAVDQTVYTLRTAGWEGFKTLLPIYLDHLINPTLTDEACLTEVYHIDGKGEEKGVVFSEMQGMENQSWFILYKKMQETLYDKNSGYSSETGGLMSELRHLTSDKIREFHKSMYRPENLCVIITGSIDQDELLEIMTEFDNELPSSTNMGTFKRPFVDSKHDEPLEEVIVKEVEFPENDETIGELSISWIGPVCNDTLTNLAVDMVGAYFSDSPISIFNKNLIEIEHPLATEVYYDTDDFYRTALNFNFGGVPTENLQELDTKIKQLLKEQTTPNKIELEYMKQIIEQQKLKFIANVENSASLFSEMATLEFIYGATDGSDLSKWTKDLKEFEILMDWTSEQWSQLIDTFFVQNKSATILGKPSSKLNESMKLQNKQILEDIKTKYGEAKLADLQLKLEAAQKINDKPIPDELITQFPAPDPSKISFIHTKSYKAGNIKNGIVDNSTNQYIDNDDISKLLQKDTPTTDFPLFIHFEHFKSQFVTIQLVMSSKTIDGNLLSYMSVMEEIFSLSIEIPKEDGSVEYIPYEKVIADINRDLIEHQLDNGFDDQFLELITVKIKFEIKNYQKAINWLYNITNHVKFEMNRIRIIIEKIINSLPEKKRNDELMMHSSQCRHLFNENSLRKAQDSIYTESFYKNLLEKIDNQDNGFEEIEKDLNKFKQQLFQLDNIKVIILGDVTKLKNPVSSWNRFINPPPPRPTTTKTSSKIIPFKDLPKSYQYRSSLGESCHGEAFVVNIPSADSTHLTSITKIPHGNYLDEDIFRIALATELLTVMEGPFWKAIRGAGLAYGVHMNRNIETGYLSFVIYRGSDCIQSWCKAKTIIEQYINGELLVDELSISNAINSLINELINNHNNNQYNTAVAKISDNIFKNRGPNYIEFFIKKLHKFKNNGNYQDEIIYILKKYFIKLFDANHSTIFTSLPTDKIETVAGFFNKQGYNINVEDIGSEEYSEEEEEEGEEYSGSEGEGNESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q59S77</accession>
    <name>Q59S77_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C602230WA</name>
        <name evidence="9" type="ordered locus">orf19.10967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712503.1">
        <property type="nucleotide sequence ID" value="XM_707410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59S77"/>
    <dbReference type="SMR" id="Q59S77"/>
    <dbReference type="FunCoup" id="Q59S77">
        <property type="interactions" value="1297"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59S77"/>
    <dbReference type="GeneID" id="3645866"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602230WA"/>
    <dbReference type="CGD" id="CAL0000183488">
        <property type="gene designation" value="orf19.10967"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02230W_A"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="InParanoid" id="Q59S77"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001151">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="191"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="648"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000183488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW30158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="684" mass="77884" checksum="71F6C02500FB39E7" modified="2005-04-26" version="1">MENSNKISLHPEQKKWKAPKGPKPIHHKNKNLIGLGRTIANQRSKENSIQYLPDGEMRFTTDKKEANWVKLRSVTQENALDEFLSTAELADTDFTADKNQQVKIIKVGNTSIVNSNGLLSTDEMLAMRQKHMMFENKLTIPKRPKWNKNQSKIEIDRQENLAFLSWRRELAQLTENNDLLLTPFERNLEVWKQLWRVVERCDLIVQIVDARNPLFFRSIDLDKYVTSLSDPDNNKAKNNLLLVNKADMLTRDQRIAWAEYFKLKKINYVFFSAAKANELLEKEREELENIQNSTGSSSSSSRNTNNNAAAAAVDAEQEEGEANDSIRILKIEELEKLFMDSAPKFEVDPEFPDRKLQIGLVGYPNVGKSSTINALVGSKKVSVSSTPGKTKHFQTIHLSPDVLLCDCPGLVFPNFAYTNAELVCNGVLPIDQLREHIPPVSLVCQRIPKFFLEAVYGIHIPIQKVEDGGNGEYPTARELLNAYARARGYMTQGFGSADEPRAARYILKDYVNGKLLYVNPPPKEATNKNEWILPNLQESRIFNRELYTLNHLPESRQHQIVSAMQHKHIPVDEFNLEKDLTKLNFSQHIAAITGSGDSKDEDNKLRDNNQSQSEAKTLFYGGKQAALESAGDELDREFFAMNNISGKFATPFHKKNNSNTEKNSNKKHNKKNKKQDKKVRVVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q59T88</accession>
    <name>Q59T88_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">UGA2</name>
        <name evidence="11" type="ordered locus">CAALFM_C101810CA</name>
        <name evidence="10" type="ordered locus">orf19.12018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712968.1">
        <property type="nucleotide sequence ID" value="XM_707875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59T88"/>
    <dbReference type="SMR" id="Q59T88"/>
    <dbReference type="STRING" id="237561.Q59T88"/>
    <dbReference type="GeneID" id="3645436"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101810CA"/>
    <dbReference type="CGD" id="CAL0000192412">
        <property type="gene designation" value="UGA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01810C_A"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="InParanoid" id="Q59T88"/>
    <dbReference type="OMA" id="IGELFCK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000192412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW25868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="509" mass="54642" checksum="A4C412CF02E6ECCB" modified="2005-04-26" version="1">MITKRLYSTIESSKKVLGTLSNPNLVKTEAYINGKWVPSSSGETFTVTNPALYPNPESELATMQSMSEEDFNSAIESADIAFNKFKKTTGRYRSELLLKLYNLMISNKDDLAKLVVLENGKPYADALGEVNYAASFFQWFSEEAPRIYGDIIPSANGTNRILTFKQPIGVCGILTPWNFPLAMITRKLGAAIATGCTAVIKPASETPLSATALAFLAEEAGFPPGVINVLPSADASGSGKYLTEHPLIKKVSFTGSTPVGKILMNQSASTLKKLSFELGGNAPFIAFDDVDVDKAVNGAIASKFRSSGQTCVCANRIFVHEKIYDEFAKKFVDKLKNETVLGNPLASGVTHGPVIHDRSMKKVRQHIEDAVDKGATILLGGSKRPDLGENFHDLTVLGDVTTEMLITQEETFGPVAPLIKFKTDDEVIKMANDTTVGLAGYFYANDVAKVFKIAEALNVGMLGVNTGAISEAALPFGGVGESGFGREGSKFGVEDYLVIKSAVLGGIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q59TU5</accession>
    <name>Q59TU5_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">MRF1</name>
        <name evidence="15" type="ordered locus">CAALFM_C111700CA</name>
        <name evidence="14" type="ordered locus">orf19.8742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713016.1">
        <property type="nucleotide sequence ID" value="XM_707923.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59TU5"/>
    <dbReference type="SMR" id="Q59TU5"/>
    <dbReference type="STRING" id="237561.Q59TU5"/>
    <dbReference type="GeneID" id="3645321"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111700CA"/>
    <dbReference type="CGD" id="CAL0000182133">
        <property type="gene designation" value="MRF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11700C_A"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="Q59TU5"/>
    <dbReference type="OMA" id="WLMTWIR"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0000182133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AOW26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="359" mass="38669" checksum="81DD4A27E0E5C953" modified="2005-04-26" version="1">MTITGKATTYSAPGSDLPNVLQQTTFVIDEAAIQPNDVVVKTLATPINPSDVAQIFGGYNDAVPSTRLGSDTTPQPLSVGGNEGVFKVIQIGSNVKNYEVGDVVIPKLPGFGTWRTHAVVDITQDSDLTPFIKVNDLTIDQAATISINPSTAYQLLHQFVKDWKSGDWIIQNAGNSQASKYLTQLAKLINVNVLSIVRDGKPQELYDELYELGATKVLSESEFLHPEFNIEDVTKGEGNVRLALNSIGGETVGGLVKGLSRNGVLATYGVLGGGKISYDGRIQLFKNISTRAYWLTANTKANPQSKVDTVEAVSKLFKEGKLKVAAYNKVKFDSTGDLKATILNTIGKSKSGKQVVIYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-04-09" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q59VP0</accession>
    <accession>A0A1D8PD71</accession>
    <name>BST1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>GPI inositol-deacylase</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BST1</name>
        <name type="ordered locus">CAALFM_C104190CA</name>
        <name type="ORF">CaO19.1053</name>
        <name type="ORF">CaO19.8655</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Lacks the C-terminal half of the classical GPI inositol-deacylases.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713657.2">
        <property type="nucleotide sequence ID" value="XM_708564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59VP0"/>
    <dbReference type="SMR" id="Q59VP0"/>
    <dbReference type="STRING" id="237561.Q59VP0"/>
    <dbReference type="ESTHER" id="canal-q59vp0">
        <property type="family name" value="PGAP1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_04190C_A-T">
        <property type="protein sequence ID" value="C1_04190C_A-T-p1"/>
        <property type="gene ID" value="C1_04190C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644717"/>
    <dbReference type="KEGG" id="cal:CAALFM_C104190CA"/>
    <dbReference type="CGD" id="CAL0000175277">
        <property type="gene designation" value="BST1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_04190C_A"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058462_0_0_1"/>
    <dbReference type="InParanoid" id="Q59VP0"/>
    <dbReference type="OMA" id="DQVEYVT"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="PRO" id="PR:Q59VP0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:symbiont-mediated evasion of host immune response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00120">
        <property type="entry name" value="LIPASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000277632" description="GPI inositol-deacylase">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="390" mass="44366" checksum="785F6E0DCE00B552" modified="2017-03-15" version="2">MLSKRLFPYSNLFPRSRKYKFIVYFIICLTIIISALGVYLYSIPIVSPNQPQCDMVWMSPSYARIRAFDETHTKYASKYNLYLYREQDVDKMPNENENEDGNEGFTSLDGIPALFIHGNAGSFEQVRSIAARCSEMYYNDGRFKEKYPHARNIDFFTADFNEELSAFKGLRDQVEYVTQAISFIVDLYPQNPNRNIILIGHSMGGLVARIAASRQQHESNVDIILTLATPHSDPFPWLPKTSDFPDEVGLISIYSSVDLMVPPSVVTPKSKSDHFFSVDAAKLLGVPIDHQGIVWCGQLREKLSEALIGISGLNTLQDRMKVFKKIFSGDRKELGPTPIFGLAKLKLKLLQSWVHLLSLTIFALKWTIIVLAIIQLRKVYTKFNNPPPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q59WI9</accession>
    <name>Q59WI9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ordered locus">CAALFM_C111020WA</name>
        <name evidence="21" type="ordered locus">orf19.9848</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_713917.1">
        <property type="nucleotide sequence ID" value="XM_708824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59WI9"/>
    <dbReference type="SMR" id="Q59WI9"/>
    <dbReference type="FunCoup" id="Q59WI9">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59WI9"/>
    <dbReference type="GeneID" id="3644420"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111020WA"/>
    <dbReference type="CGD" id="CAL0000186071">
        <property type="gene designation" value="orf19.9848"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11020W_A"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="InParanoid" id="Q59WI9"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
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        <location>
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</entry>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
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                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
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    <reference evidence="2 3" key="3">
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
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        </source>
    </evidence>
    <sequence length="150" mass="17140" checksum="4BE42A500BC19A80" modified="2005-04-26" version="1">MQVINDTSLLSEKYLTVVSYDDMTSPNYMAKLSKLSNSLHKQGLDLHKVCLIMRFKIKLKTSLQIAGVNYQVYSTISKLNGLISSLYEGLDLDCESSIDIKFNDFGDFGDSIKRCISIENFDFFMENEFLVSLENDSDPDTRLVYDNFIV</sequence>
</entry>
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    <accession>Q59Z11</accession>
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        <recommendedName>
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        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714878.1">
        <property type="nucleotide sequence ID" value="XM_709785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Z11"/>
    <dbReference type="SMR" id="Q59Z11"/>
    <dbReference type="FunCoup" id="Q59Z11">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Z11"/>
    <dbReference type="GeneID" id="3643479"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207320WA"/>
    <dbReference type="CGD" id="CAL0000184019">
        <property type="gene designation" value="ARP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07320W_A"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="InParanoid" id="Q59Z11"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000184019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="419" mass="46648" checksum="A80E36D73B7EFD88" modified="2005-04-26" version="1">MSMNTPAVVMDNGTGLTKLGFAGNDSPSFVFPTAIATSSASSKAGKGPRGSSLASKRGLEDLDFYIGDEALEAASGSQYGLHYPIKHGQIEDWDQMERFWESSIFKYLRCEPEDHYFLLTEPPLNPPENRESTAEIMFESFNCAGLYIAVQAVLALAASWTSPKVQDRSLSGTVIDSGDGVTHVIPVAEGYVIGAAIKNIPLAGRDITLFIQQLLRDRGEADTSLQTAEKIKQEFCYVCPDIVQEFSRFDQYPQEKFAQYMVEYTDKNKRNTVDVGYERFLAPEIFFNPEICSSDFLTPLPTVVDQVIQASPIDVRKKLYKNIVLSGGSTMFKDFGKRLQRDLKSIVSERIQLSERLSGSQSTGVDVQVISHKKQRNAVWFGGSLLAQTSEFKSYCYTKSDYDEYGPSIVRNFSLFSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q59Z33</accession>
    <name>Q59Z33_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rfa2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">RFA2</name>
        <name evidence="9" type="ordered locus">CAALFM_C207120WA</name>
        <name evidence="8" type="ordered locus">orf19.9807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714857.1">
        <property type="nucleotide sequence ID" value="XM_709764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59Z33"/>
    <dbReference type="SMR" id="Q59Z33"/>
    <dbReference type="FunCoup" id="Q59Z33">
        <property type="interactions" value="943"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q59Z33"/>
    <dbReference type="GeneID" id="3643506"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207120WA"/>
    <dbReference type="CGD" id="CAL0000176295">
        <property type="gene designation" value="RFA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07120W_A"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051033_0_0_1"/>
    <dbReference type="InParanoid" id="Q59Z33"/>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="174"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000176295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="272" mass="29376" checksum="99A1424014CEC7B3" modified="2005-04-26" version="1">MSDFEYDNNNTGAFGNISQGGFNTEHAGSSQRQTTTQVRQSLTPVTIKQINDATQPVPDGEFKVNNVELNMISFVGVVRNVENTNASIAVTIEDGTGSIDVRKWVDETISSAEEDFEKYNEMKGKYVYVGGSLKQFNNRKTVQNASISLITDSNQIVYHHLSAIEHHLKAQGITAADAASAGAGQATNSTASAGSGLFMDNPTSLSKDTGSLTDQVIAVLKEASRTMPDGVPVDYVAEKLSITKEESQFQLLKLNDEGKAYAGYDDNSYLVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A013</accession>
    <accession>A0A1D8PSJ7</accession>
    <name>EFM7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM7</name>
        <name type="synonym">NNT1</name>
        <name type="ordered locus">CAALFM_CR03760WA</name>
        <name type="ORF">CaO19.11853</name>
        <name type="ORF">CaO19.4375</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
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        <property type="protein sequence ID" value="AOW26217.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_710758.1"/>
    </dbReference>
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        <property type="gene designation" value="orf19.8046"/>
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    <dbReference type="eggNOG" id="ENOG502SRYK">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050549_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A2C5"/>
    <dbReference type="OMA" id="PECKKMS"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000176576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="373" mass="42120" checksum="94919B204C41D86C" modified="2005-04-26" version="1">MPANGSFEKMSRPATAFQKVLDKVGSVFSSTETSRSQHDSQLDDKATNIFSVSSQKLYSKLSKMLKIETRSKNLKMELCNDFGVWGQSIPNLESSAFVKEFSALLNTQTNNQTILQEKMERLKLSLSFVNEREKKQKGLITAKLKLEKQLKEAKAKFGPNASNTILLNEKAEEVDCNLQVVEQQYIRSIINDLKDALIDYAYSMSAAARKAEDSSSSFIQYMTAVENDMVAGSIENDFVRFSPNKYSKLSKRKESKYQSPNLLDGGIVGSGVQQLKVKNYNLPTPQSPCPECKKMSPCIHTDGAKVIQPSQRDNNHQQQHQQVHQQTQLRTFSQPNRNFTVNLQHPSDDSLGNEVPLYTTNRENSMPFSDHWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A2C7</accession>
    <name>Q5A2C7_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial 37S ribosomal protein RSM22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">RSM22</name>
        <name evidence="10" type="ordered locus">CAALFM_C105500WA</name>
        <name evidence="9" type="ordered locus">orf19.8044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715849.1">
        <property type="nucleotide sequence ID" value="XM_710756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A2C7"/>
    <dbReference type="FunCoup" id="Q5A2C7">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A2C7"/>
    <dbReference type="GeneID" id="3642506"/>
    <dbReference type="KEGG" id="cal:CAALFM_C105500WA"/>
    <dbReference type="CGD" id="CAL0000174389">
        <property type="gene designation" value="RSM22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_05500W_A"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024759_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A2C7"/>
    <dbReference type="OMA" id="HRKCPLQ"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180026">
        <property type="term" value="P:mitochondrial small ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016522">
        <property type="entry name" value="RSM22_mit_bud"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007797">
        <property type="entry name" value="RSM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000174389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A3L6</accession>
    <name>Q5A3L6_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C112110CA</name>
        <name evidence="1" type="ordered locus">orf19.12719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716323.1">
        <property type="nucleotide sequence ID" value="XM_711230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A3L6"/>
    <dbReference type="SMR" id="Q5A3L6"/>
    <dbReference type="GeneID" id="3642054"/>
    <dbReference type="KEGG" id="cal:CAALFM_C112110CA"/>
    <dbReference type="CGD" id="CAL0000182464">
        <property type="gene designation" value="orf19.12719"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_12110C_A"/>
    <dbReference type="eggNOG" id="ENOG502RMRG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129393_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A3L6"/>
    <dbReference type="OMA" id="NIIIQWK"/>
    <dbReference type="OrthoDB" id="4081634at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000182464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="126" mass="14420" checksum="4DAE06B794D682E1" modified="2005-04-26" version="1">MASASTTNPGIYSARQILLLAQLLHSDNINNVDKLTSLNENKIQNIIIQWKQHKINHLNSATINNKDSTIKLQTTVQLVELYKNLLKKYEVTNTEELANAAYFKRMSELEGIIEKDKQMFEDTLNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A449</accession>
    <accession>A0A1D8PMD9</accession>
    <name>RU2A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>U2 small nuclear ribonucleoprotein A'</fullName>
            <shortName>U2 snRNP A'</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LEA1</name>
        <name type="ordered locus">CAALFM_C405750CA</name>
        <name type="ORF">CaO19.1260</name>
        <name type="ORF">CaO19.8845</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716568.1">
        <property type="nucleotide sequence ID" value="XM_711475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A449"/>
    <dbReference type="SMR" id="Q5A449"/>
    <dbReference type="FunCoup" id="Q5A449">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A449"/>
    <dbReference type="EnsemblFungi" id="C4_05750C_A-T">
        <property type="protein sequence ID" value="C4_05750C_A-T-p1"/>
        <property type="gene ID" value="C4_05750C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641807"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405750CA"/>
    <dbReference type="CGD" id="CAL0000184113">
        <property type="gene designation" value="LEA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05750C_A"/>
    <dbReference type="eggNOG" id="KOG1644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061027_3_0_1"/>
    <dbReference type="InParanoid" id="Q5A449"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="PRO" id="PR:Q5A449"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001728">
        <property type="entry name" value="Component of U2 snRNP, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0433">Leucine-rich repeat</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000074181" description="U2 small nuclear ribonucleoprotein A'">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="233" mass="27168" checksum="4B207D7EBAADBD1C" modified="2005-04-26" version="1">MRLTAQVINEAPEILNPEGKLTLLLRDLQITELENLAITQNKYQVIDLSNNDLISLGNIPKRFNNLQCLLLSNNNISYIDDESFPSDNHITSITLFNNNIYQFQKSFKDKFPKLETLILLGNPITEMENYRYFIIWLIPSLKVLDFKKVKQAERKTSEDMFGTNRDEFNSLAQQMFKNENTEIKLDGKSDRQVKNFVKKMTDEERQQLLKKLETATSIEEIERIENDLKEGAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A477</accession>
    <accession>A0A1D8PE59</accession>
    <accession>Q96WN8</accession>
    <name>GMT_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>GDP-mannose transporter</fullName>
            <shortName>GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">VRG4</name>
        <name type="ordered locus">CAALFM_C107700CA</name>
        <name type="ORF">CaO19.1232</name>
        <name type="ORF">CaO19.8817</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="J. Bacteriol." volume="184" first="29" last="42">
            <title>Molecular and phenotypic analysis of CaVRG4, encoding an essential Golgi apparatus GDP-mannose transporter.</title>
            <authorList>
                <person name="Nishikawa A."/>
                <person name="Poster J.B."/>
                <person name="Jigami Y."/>
                <person name="Dean N."/>
            </authorList>
            <dbReference type="PubMed" id="11741841"/>
            <dbReference type="DOI" id="10.1128/JB.184.1.29-42.2002"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>SC5314 / CAI4 / ATCC MYA-682</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Involved in hyphal formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF164627">
        <property type="protein sequence ID" value="AAK74075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716540.2">
        <property type="nucleotide sequence ID" value="XM_711447.2"/>
    </dbReference>
    <dbReference type="PDB" id="9S35">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A=34-371"/>
    </dbReference>
    <dbReference type="PDB" id="9S36">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A=34-371"/>
    </dbReference>
    <dbReference type="PDBsum" id="9S35"/>
    <dbReference type="PDBsum" id="9S36"/>
    <dbReference type="AlphaFoldDB" id="Q5A477"/>
    <dbReference type="EMDB" id="EMD-54523"/>
    <dbReference type="EMDB" id="EMD-54524"/>
    <dbReference type="SMR" id="Q5A477"/>
    <dbReference type="FunCoup" id="Q5A477">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A477"/>
    <dbReference type="TCDB" id="2.A.7.13.2">
        <property type="family name" value="the drug/metabolite transporter (dmt) superfamily"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5A477">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C1_07700C_A-T">
        <property type="protein sequence ID" value="C1_07700C_A-T-p1"/>
        <property type="gene ID" value="C1_07700C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641768"/>
    <dbReference type="KEGG" id="cal:CAALFM_C107700CA"/>
    <dbReference type="CGD" id="CAL0000182900">
        <property type="gene designation" value="VRG4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_07700C_A"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="InParanoid" id="Q5A477"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="PRO" id="PR:Q5A477"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005458">
        <property type="term" value="F:GDP-mannose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990570">
        <property type="term" value="P:GDP-mannose transmembrane transport"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000333515" description="GDP-mannose transporter">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
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            <begin position="146"/>
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        <location>
            <begin position="333"/>
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        </location>
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        <location>
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        <original>H</original>
        <variation>Y</variation>
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PubMed" id="11741841"/>
        </source>
    </evidence>
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    <sequence length="371" mass="41236" checksum="4BD03B8DF7AB881C" modified="2017-03-15" version="2">MGVISFYLIGQLLYLIRKKYTTTYRQQQQHQYNMDSKHSTSSSSSGSLATRISNSGPISIAAYCLSSILMTVTNKYVLSGFSFNLNFFLLAVQSIVCIVTIGSLKSLNIITYRQFNKDEAKKWSPIAFLLVAMIYTSSKALQYLSIPVYTIFKNLTIILIAYGEVIWFGGKVTTMALSSFLLMVLSSVIAYYGDNAAVKSHDDAFALYLGYFWMLTNCFASAAFVLIMRKRIKLTNFKDFDTMYYNNLLSIPILLICSFIFEDWSSANVSLNFPADNRVTTITAMILSGASSVGISYCSAWCVRVTSSTTYSMVGALNKLPIALSGLIFFEAAVNFWSVSSIFVGFGAGLVYAVAKQKQQKEQSQQLPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AOW29480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="325" mass="36429" checksum="9B5BDFE1CDECE423" modified="2005-04-26" version="1">MSSHIFKDIQDKENELKTSGIRRKGIISNENAGPLLSKDSNSRQVQQPQQTQQQQQQSKFTNKRIPLGGKNHNSNKLLLNRSQSSLNTKPTTQGITNVKPPSLPKSNSSLGFSVVSDQPTEQQKQLPQPFVVHNEQVLPVKRKLLQDTKDELSQNSKRVKLEKKESNANTFTDSLTKPTQNVLAHVDDLQTTISSKTDQLNSSNLTHNDINRNNVDPVKRNSRLKAIDDLVESHWQDPIETIPETVGAENNNGEQLEELDIKFFSTPNESFDIGDLDENHLANNEQKLSLELDFEDESNVGEIPIIEGIDEEIGLTSDDLDNLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A5B6</accession>
    <accession>Q3MP58</accession>
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        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">ECM39</name>
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        <name evidence="13" type="ordered locus">orf19.12631</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716986.1">
        <property type="nucleotide sequence ID" value="XM_711893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A5B6"/>
    <dbReference type="FunCoup" id="Q5A5B6">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A5B6"/>
    <dbReference type="CAZy" id="GT22">
        <property type="family name" value="Glycosyltransferase Family 22"/>
    </dbReference>
    <dbReference type="GeneID" id="3641386"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702970WA"/>
    <dbReference type="CGD" id="CAL0000200311">
        <property type="gene designation" value="ECM39"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02970W_A"/>
    <dbReference type="eggNOG" id="KOG2516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008917_4_0_1"/>
    <dbReference type="InParanoid" id="Q5A5B6"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0000200311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AOW30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="584" mass="66231" checksum="4D3FC427AC2EA344" modified="2005-04-26" version="1">MYRYNKVLDATLIALVSFHLVISPFTKVEESFNIQAIHDILKFGIFPLETIDNYDHKQFPGVVPRTFLGSLVVAGLAKPILLLSSAFGFEIEGYELQKLVRAVLGLVNVLMLIRLRDSINKITFSDKKSKRKGLIGFWYTTLLLSQFHLLYYSSRTLPNFIALPLVNFSLSKIIQGDLSGLTWLAFTGIVFRLEVGLFGLIIAIVSSLGFGQSNIFGNIIYLAMGTLLGGFTSFCIDSYFWGRPLIPEIDSFIFNIVQGKSTEWGTEPWDTYFKKYLFQLFRPPVILMLAIPGLINDPANDGTKFGDKKSVPHPARYSLRILFISSILFIAAMSFQPHKEWRFIVYTIPIFTLQAANGVTNICQKWGLSVLNKVLIFIIGANVIISSLLSLHMGYISSFNYPGGDALQFTNNYILENYKNETVSVHMDVPACMTGITRFGELDGKFASYDKSEQDFDITNYDIIITHNEVPNWELLHSSRVFDGISLRMFIQIFMAQRKDRSTIFNITKLILSEFAQGEFGTVHDMLRSTITTVEYLNVYKNVNKNPHMVQGVPETKIIDQEIDPEEIRQDVNEQIDKFESAVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6A4</accession>
    <accession>A0A1D8PM76</accession>
    <accession>Q5A6I5</accession>
    <name>KAE1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName>t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein KAE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KAE1</name>
        <name type="ordered locus">CAALFM_C404920WA</name>
        <name type="ORF">CaO19.11267</name>
        <name type="ORF">CaO19.3787</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717192.1">
        <property type="nucleotide sequence ID" value="XM_712099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6A4"/>
    <dbReference type="SMR" id="Q5A6A4"/>
    <dbReference type="FunCoup" id="Q5A6A4">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6A4"/>
    <dbReference type="EnsemblFungi" id="C4_04920W_A-T">
        <property type="protein sequence ID" value="C4_04920W_A-T-p1"/>
        <property type="gene ID" value="C4_04920W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641172"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404920WA"/>
    <dbReference type="CGD" id="CAL0000176786">
        <property type="gene designation" value="orf19.11267"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04920W_A"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="InParanoid" id="Q5A6A4"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="PRO" id="PR:Q5A6A4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000278929" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <sequence length="372" mass="41103" checksum="D5A077C466AB8742" modified="2005-04-26" version="1">MVVDLDKYLKPGKDHYLALGLEGSANKLGVGVIKHNKGPLSSTNRAEVLSNIRDTYITPPGEGFLPRDTARHHRNWVVRIIKQALATAKIAGKDIDVICFTQGPGMGAPLQSVVIAARTLAQLWNIPIVGVNHCVGHIEMGREITGAENPVVLYVSGGNTQVIAYSKQRYRIFGETLDIAIGNCLDRFARTLKIPNEPAPGYNIEQMAKKGKHLVPLPYTVKGMDLSMSGILAAIDSIAKEMFGKQQKKLIDEESGEPITAEDLCFSLQETLFSMLVEITERALAHVDSNQVLIVGGVGSNQRLQEMMKLMIQDRKNGQIYATDERFCIDNGIMIAHAGLLSYRTGQTNQLNNTVCTQRFRTDEVFVKWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A6S2</accession>
    <name>Q5A6S2_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Proteasome regulatory particle base subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">RPT4</name>
        <name evidence="14" type="ordered locus">CAALFM_CR04000WA</name>
        <name evidence="13" type="ordered locus">orf19.8112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717345.1">
        <property type="nucleotide sequence ID" value="XM_712252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A6S2"/>
    <dbReference type="SMR" id="Q5A6S2"/>
    <dbReference type="FunCoup" id="Q5A6S2">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5A6S2"/>
    <dbReference type="GeneID" id="3640966"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR04000WA"/>
    <dbReference type="CGD" id="CAL0000188624">
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    <dbReference type="eggNOG" id="KOG0651">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="Q5A6S2"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="205"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
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            <end position="92"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
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    <accession>O94045</accession>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
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                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
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                <person name="Magee P.T."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
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        <property type="entry name" value="His_PPase_superfam"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR48100:SF1">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53254">
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            <begin position="1"/>
            <end position="22"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000180276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW26464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37981" checksum="EE9AE15765443620" modified="2005-04-26" version="1">MTRQSLLTPTKTDYSDAHGNSEGAQQYKEKWIKIKHQRDENGNLKYPWDFEVVHGFFVQSDMSTDDFGFNHTFQNMGRKKSWEDIKAELIQLNNEAPDNVQYKLIFLARHGHSTQTQIVELEGLHLWHEKNCKLTGNDQFTWAPDSELTEIGLEQAKENREFWKSELLLGAPIPSKFHTSPLQRACSTLVITWHDLKPVETRPIVCEKLREKIGKNLSDKRSTRSEIHEKFGDTYGFITDGLEEEDIYFTETRETMPEQSLRLNGYLQDLFEQDCKSGKVDKKSAVDNIFISTTSHSGTIRSVINVVGHRNFTVSTGGMLPIVVKATRRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8A2</accession>
    <accession>A0A1D8PRW8</accession>
    <name>NPC2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
            <shortName>PG/PI-TP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NPC2</name>
        <name type="ordered locus">CAALFM_CR01280CA</name>
        <name type="ORF">CaO19.10736</name>
        <name type="ORF">CaO19.3226</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW30889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_717917.2">
        <property type="nucleotide sequence ID" value="XM_712824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8A2"/>
    <dbReference type="SMR" id="Q5A8A2"/>
    <dbReference type="FunCoup" id="Q5A8A2">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A8A2"/>
    <dbReference type="EnsemblFungi" id="CR_01280C_A-T">
        <property type="protein sequence ID" value="CR_01280C_A-T-p1"/>
        <property type="gene ID" value="CR_01280C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640400"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR01280CA"/>
    <dbReference type="CGD" id="CAL0000192697">
        <property type="gene designation" value="orf19.10736"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_01280C_A"/>
    <dbReference type="eggNOG" id="KOG4680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097982_0_1_1"/>
    <dbReference type="InParanoid" id="Q5A8A2"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="PRO" id="PR:Q5A8A2"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000019875" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000019876" description="Phosphatidylglycerol/phosphatidylinositol transfer protein">
        <location>
            <begin position="57"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="192" mass="21197" checksum="F2E54ED6442788EF" modified="2017-04-12" version="2" precursor="true">MVSFKNLAIVTLAVTTTSVEGISFSNIYLNKAITIFKNPTSLIPSFSNSKLINYQNTKPIPGDSPIEVCDASEKQLLHLDEVIVTPNPPVAGQNLTFTAVGTLDKTIEEGAYVEVEVRYGFIKLIHQTYDLCEEIVKVDLQCPIKSGKQTITKNVEIPEEVPPGKYLVVARAYTKDDEYITCLTATIIFPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8M9</accession>
    <name>Q5A8M9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C603530CA</name>
        <name evidence="1" type="ordered locus">orf19.13142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710070.2">
        <property type="nucleotide sequence ID" value="XM_704978.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8M9"/>
    <dbReference type="GeneID" id="3640260"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603530CA"/>
    <dbReference type="CGD" id="CAL0000174575">
        <property type="gene designation" value="orf19.13142"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03530C_A"/>
    <dbReference type="HOGENOM" id="CLU_1916783_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A8M9"/>
    <dbReference type="OrthoDB" id="4025449at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000174575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="133" mass="15518" checksum="EDAC0A393DA97FA8" modified="2005-04-26" version="1">MKFSISLDQFLQYYNEHGKHPELLKSSQFDSNKIIDSLASNINDSSNQLQLPPPQEVNINDLELDVENLPQCMPPANQEEYENYLMMKKIHHDNFLREVNEKGLRLKNQMTDSTQPPFDSSRSSIEFLRMMGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2025-04-09" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A8N2</accession>
    <accession>A0A1D8PQ73</accession>
    <name>CARP4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Secreted aspartic protease 4</fullName>
            <shortName evidence="18">ACP 4</shortName>
            <shortName evidence="18">Aspartate protease 4</shortName>
            <ecNumber evidence="12 16">3.4.23.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Candidapepsin-4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SAP4</name>
        <name type="ordered locus">CAALFM_C603500CA</name>
        <name type="ORF">CaO19.13139</name>
        <name type="ORF">CaO19.5716</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1994" name="J. Bacteriol." volume="176" first="1702" last="1710">
            <title>A fourth secreted aspartyl proteinase gene (SAP4) and a CARE2 repetitive element are located upstream of the SAP1 gene in Candida albicans.</title>
            <authorList>
                <person name="Miyasaki S.H."/>
                <person name="White T.C."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="7907585"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2001" name="J. Med. Microbiol." volume="50" first="743" last="747">
            <title>Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo.</title>
            <authorList>
                <person name="Schaller M."/>
                <person name="Januschke E."/>
                <person name="Schackert C."/>
                <person name="Woerle B."/>
                <person name="Korting H.C."/>
            </authorList>
            <dbReference type="PubMed" id="11478679"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2002" name="Infect. Immun." volume="70" first="3689" last="3700">
            <title>Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs.</title>
            <authorList>
                <person name="Felk A."/>
                <person name="Kretschmar M."/>
                <person name="Albrecht A."/>
                <person name="Schaller M."/>
                <person name="Beinhauer S."/>
                <person name="Nichterlein T."/>
                <person name="Sanglard D."/>
                <person name="Korting H.C."/>
                <person name="Schafer W."/>
                <person name="Hube B."/>
            </authorList>
            <dbReference type="PubMed" id="12065511"/>
            <dbReference type="DOI" id="10.1128/IAI.70.7.3689-3700.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="J. Biochem." volume="150" first="431" last="438">
            <title>Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.</title>
            <authorList>
                <person name="Aoki W."/>
                <person name="Kitahara N."/>
                <person name="Miura N."/>
                <person name="Morisaka H."/>
                <person name="Yamamoto Y."/>
                <person name="Kuroda K."/>
                <person name="Ueda M."/>
            </authorList>
            <dbReference type="PubMed" id="21646240"/>
            <dbReference type="DOI" id="10.1093/jb/mvr073"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2002" name="J. Mol. Recognit." volume="15" first="135" last="144">
            <title>Analysis of the interaction between the aspartic peptidase inhibitor SQAPI and aspartic peptidases using surface plasmon resonance.</title>
            <authorList>
                <person name="Farley P.C."/>
                <person name="Christeller J.T."/>
                <person name="Sullivan M.E."/>
                <person name="Sullivan P.A."/>
                <person name="Laing W.A."/>
            </authorList>
            <dbReference type="PubMed" id="12203839"/>
            <dbReference type="DOI" id="10.1002/jmr.568"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="Trop. Biomed." volume="28" first="589" last="598">
            <title>Expression analysis of SIR2 and SAPs1-4 gene expression in Candida albicans treated with allicin compared to fluconazole.</title>
            <authorList>
                <person name="Khodavandi A."/>
                <person name="Alizadeh F."/>
                <person name="Harmal N.S."/>
                <person name="Sidik S.M."/>
                <person name="Othman F."/>
                <person name="Sekawi Z."/>
                <person name="Chong P.P."/>
            </authorList>
            <dbReference type="PubMed" id="22433888"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2005" name="Infect. Immun." volume="73" first="1828" last="1835">
            <title>Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection.</title>
            <authorList>
                <person name="Taylor B.N."/>
                <person name="Staib P."/>
                <person name="Binder A."/>
                <person name="Biesemeier A."/>
                <person name="Sehnal M."/>
                <person name="Rollinghoff M."/>
                <person name="Morschhauser J."/>
                <person name="Schroppel K."/>
            </authorList>
            <dbReference type="PubMed" id="15731084"/>
            <dbReference type="DOI" id="10.1128/IAI.73.3.1828-1835.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2012" name="Pol. J. Microbiol." volume="61" first="247" last="256">
            <title>In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms.</title>
            <authorList>
                <person name="Staniszewska M."/>
                <person name="Bondaryk M."/>
                <person name="Siennicka K."/>
                <person name="Kurek A."/>
                <person name="Orlowski J."/>
                <person name="Schaller M."/>
                <person name="Kurzatkowski W."/>
            </authorList>
            <dbReference type="PubMed" id="23484407"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2011" name="Dis. Model. Mech." volume="4" first="515" last="525">
            <title>Pathogen and host factors are needed to provoke a systemic host response to gastrointestinal infection of Drosophila larvae by Candida albicans.</title>
            <authorList>
                <person name="Glittenberg M.T."/>
                <person name="Kounatidis I."/>
                <person name="Christensen D."/>
                <person name="Kostov M."/>
                <person name="Kimber S."/>
                <person name="Roberts I."/>
                <person name="Ligoxygakis P."/>
            </authorList>
            <dbReference type="PubMed" id="21540243"/>
            <dbReference type="DOI" id="10.1242/dmm.006627"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2013" name="Peptides" volume="48" first="49" last="58">
            <title>Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.</title>
            <authorList>
                <person name="Bochenska O."/>
                <person name="Rapala-Kozik M."/>
                <person name="Wolak N."/>
                <person name="Bras G."/>
                <person name="Kozik A."/>
                <person name="Dubin A."/>
                <person name="Aoki W."/>
                <person name="Ueda M."/>
                <person name="Mak P."/>
            </authorList>
            <dbReference type="PubMed" id="23927842"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2013.07.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="14">
        <citation type="journal article" date="2016" name="Acta Biochim. Pol." volume="63" first="403" last="410">
            <title>The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5.</title>
            <authorList>
                <person name="Bochenska O."/>
                <person name="Rapala-Kozik M."/>
                <person name="Wolak N."/>
                <person name="Aoki W."/>
                <person name="Ueda M."/>
                <person name="Kozik A."/>
            </authorList>
            <dbReference type="PubMed" id="27390786"/>
            <dbReference type="DOI" id="10.18388/abp.2016_1318"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8 11 15">Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:12065511, PubMed:21540243). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (PubMed:11478679, PubMed:12065511, PubMed:21540243). Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein (PubMed:23927842).</text>
    </comment>
    <comment type="function">
        <text evidence="16">Plays a key role in defense against host by cleaving histatin-5 (Hst 5), a peptide from human saliva that carries out fungicidal activity (PubMed:27390786). The cleavage rate decreases in an order of SAP2 &gt; SAP9 &gt; SAP3 &gt; SAP7 &gt; SAP4 &gt; SAP1 &gt; SAP8 (PubMed:27390786). The first cleavage occurs between residues 'Lys-17' and 'His-18' of Hst 5, giving DSHAKRHHGYKRKFHEK and HHSHRGY peptides (PubMed:27390786). Simultaneously, the DSHAKRHHGY and KRKFHEKHHSHRGY peptides are also formed (PubMed:27390786).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activity is inhibited by squash aspartic peptidase inhibitor (SQAPI).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="12 16">Optimum pH is 5.0 using casein-resorufin as substrate, and 6.0-7.0, the pH of the saliva, for cleavage of Hst 5.</text>
        </phDependence>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="10 13 14">Expressed during development of germ tubes, pseudohyphae and true hyphae (PubMed:23484407). Induced during host infection (PubMed:15731084). Expression is suppressed by fluconazole (PubMed:22433888).</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW30280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_712961.1"/>
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        <property type="glycosylation" value="1 site, No reported glycans"/>
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    <dbReference type="EnsemblFungi" id="C6_03500C_A-T">
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        <property type="gene ID" value="C6_03500C_A"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C603500CA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Aspartic_peptidase_A1"/>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
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        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
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    </dbReference>
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    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424296" description="Activation peptide" evidence="18">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424297" description="Secreted aspartic protease 4">
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            <begin position="76"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="293"/>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
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        </ligand>
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    <feature type="binding site" evidence="3">
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            <begin position="160"/>
            <end position="161"/>
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        <ligand>
            <name>pepstatin A</name>
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        </location>
        <ligand>
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            <begin position="293"/>
            <end position="297"/>
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        <ligand>
            <name>pepstatin A</name>
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        </ligand>
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        <location>
            <position position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="134"/>
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    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="331"/>
            <end position="369"/>
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    </evidence>
    <evidence type="ECO:0000250" key="2">
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        <source>
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</entry>
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    <accession>A0A1D8PQ83</accession>
    <accession>Q5A8L0</accession>
    <name>ALS1_CANAL</name>
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        <recommendedName>
            <fullName>Agglutinin-like protein 1</fullName>
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        <alternativeName>
            <fullName>Adhesin 1</fullName>
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    <gene>
        <name type="primary">ALS1</name>
        <name type="ordered locus">CAALFM_C603700WA</name>
        <name type="ORF">CaO19.13163</name>
        <name type="ORF">CaO19.5741</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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            </authorList>
            <dbReference type="PubMed" id="22429754"/>
            <dbReference type="DOI" id="10.1111/j.1439-0507.2012.02188.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="32">
        <citation type="journal article" date="2012" name="Mol. Microbiol." volume="86" first="284" last="302">
            <title>Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1.</title>
            <authorList>
                <person name="Fanning S."/>
                <person name="Xu W."/>
                <person name="Beaurepaire C."/>
                <person name="Suhan J.P."/>
                <person name="Nantel A."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22882910"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2012.08193.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="33">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="E35543" last="E35543">
            <title>In vivo inhibitory effect on the biofilm formation of Candida albicans by liverwort derived riccardin D.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Ma Y."/>
                <person name="Zhang L."/>
                <person name="Guo F."/>
                <person name="Ren L."/>
                <person name="Yang R."/>
                <person name="Li Y."/>
                <person name="Lou H."/>
            </authorList>
            <dbReference type="PubMed" id="22545115"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0035543"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="34">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7 8 12 13 15 24 26 27 28 30">Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology evidence="9 33">Lipid-anchor</topology>
            <topology evidence="9 33">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17 21 22 25">Secreted</location>
            <location evidence="17 21 22 25">Cell wall</location>
        </subcellularLocation>
        <text evidence="9 25 33">Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer (Probable) (PubMed:15302828). Covers the germ tube as well as the cell surface with the exception of bud scars (PubMed:22106872).</text>
    </comment>
    <comment type="induction">
        <text evidence="10 11 14 16 18 20 22 23 24 29 30">Highly expressed in biofilms with down-regulation during later stages of biofilm formation. Expression is repressed by TPK1 and SFL1, and induced by TPK2. Also under the control of TOR1. Down-regulated by Riccardin D, a macrocyclic bisbibenzyl isolated from Chinese liverwort D.hirsute which has an inhibitory effect on biofilms and virulence. Induced by caspofungin.</text>
    </comment>
    <comment type="domain">
        <text evidence="8 19 31">Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter domain that is relatively variable in length and sequence across the family.</text>
    </comment>
    <comment type="PTM">
        <text evidence="33">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="32">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718077.1">
        <property type="nucleotide sequence ID" value="XM_712984.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A8T4"/>
    <dbReference type="SMR" id="Q5A8T4"/>
    <dbReference type="BioGRID" id="1223374">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5A8T4"/>
    <dbReference type="GlyCosmos" id="Q5A8T4">
        <property type="glycosylation" value="15 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_03700W_A-T">
        <property type="protein sequence ID" value="C6_03700W_A-T-p1"/>
        <property type="gene ID" value="C6_03700W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3640280"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603700WA"/>
    <dbReference type="CGD" id="CAL0000199010">
        <property type="gene designation" value="ALS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03700W_A"/>
    <dbReference type="HOGENOM" id="CLU_003114_0_0_1"/>
    <dbReference type="InParanoid" id="Q5A8T4"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="PHI-base" id="PHI:11392"/>
    <dbReference type="PRO" id="PR:Q5A8T4"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001968">
        <property type="term" value="F:fibronectin binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043710">
        <property type="term" value="P:cell adhesion involved in multi-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036244">
        <property type="term" value="P:cellular response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000128">
        <property type="term" value="P:flocculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044399">
        <property type="term" value="P:multi-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900735">
        <property type="term" value="P:positive regulation of flocculation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044409">
        <property type="term" value="P:symbiont entry into host"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1280:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2430:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000420218" description="Agglutinin-like protein 1">
        <location>
            <begin position="18"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000420219" description="Removed in mature form" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 2">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 3">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 4">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 5">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 6">
        <location>
            <begin position="546"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 7">
        <location>
            <begin position="582"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 8">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 9">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 10">
        <location>
            <begin position="690"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 11">
        <location>
            <begin position="726"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="ALS 12">
        <location>
            <begin position="762"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="896"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="954"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="964"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="2">
        <location>
            <position position="1238"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="918"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1045"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1068"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="205"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A1D8PQ86"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11967069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12183577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="15039323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15116430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="15128742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="15302828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="15731087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="15797814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="16839200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="17510860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="17766464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="15">
        <source>
            <dbReference type="PubMed" id="18635358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="16">
        <source>
            <dbReference type="PubMed" id="18683080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="17">
        <source>
            <dbReference type="PubMed" id="18712765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="18">
        <source>
            <dbReference type="PubMed" id="19197361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="19">
        <source>
            <dbReference type="PubMed" id="19820118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="20">
        <source>
            <dbReference type="PubMed" id="20398368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="21">
        <source>
            <dbReference type="PubMed" id="20705663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="22">
        <source>
            <dbReference type="PubMed" id="20864472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="23">
        <source>
            <dbReference type="PubMed" id="21456055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="24">
        <source>
            <dbReference type="PubMed" id="22037180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="25">
        <source>
            <dbReference type="PubMed" id="22106872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="26">
        <source>
            <dbReference type="PubMed" id="22321066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="27">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="28">
        <source>
            <dbReference type="PubMed" id="22429754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="29">
        <source>
            <dbReference type="PubMed" id="22545115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="30">
        <source>
            <dbReference type="PubMed" id="22882910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="31">
        <source>
            <dbReference type="PubMed" id="7752895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="32"/>
    <evidence type="ECO:0000305" key="33">
        <source>
            <dbReference type="PubMed" id="12845604"/>
        </source>
    </evidence>
    <sequence length="1260" mass="132913" checksum="C025873111ECF06D" modified="2005-04-26" version="1" precursor="true">MLQQFTLLFLYLSIASAKTITGVFDSFNSLTWSNAANYAFKGPGYPTWNAVLGWSLDGTSANPGDTFTLNMPCVFKYTTSQTSVDLTADGVKYATCQFYSGEEFTTFSTLTCTVNDALKSSIKAFGTVTLPIAFNVGGTGSSTDLEDSKCFTAGTNTVTFNDGDKDISIDVEFEKSTVDPSGYLYASRVMPSLNKVTTLFVAPQCENGYTSGTMGFSSSNGDVAIDCSNIHIGITKGLNDWNYPVSSESFSYTKTCTSNGIQIKYQNVPAGYRPFIDAYISATDVNQYTLAYTNDYTCAGSRSQSKPFTLRWTGYKNSDAGSNGIVIVATTRTVTDSTTAVTTLPFNPSVDKTKTIEILQPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDVPYHTTTTVTSEWTGTITTTTTRTNPTDSIDTVVVQVPSPNPTVSTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTVTAPPGETDTVIIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVLIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNYTVTTTEYWSQSYATTTTITAPPGETDTVIIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVLIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVLIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNYTVTTTEYWSQSFATTTTVTAPPGGTDTVIIYESMSSSKISTSSNDITSIIPSFSRPHYVNSTTSDLSTFESSSMNTPTSISSDGMLLSSTTLVTESETTTESICSDGKECSRLSSSSGIVTNPDSNESSIVTSTVPTASTMSDSLSSTDGISATSSDNVSKSGVSVTTETSVTTIQTTPNPLSSSVTSLTQLSSIPSVSESESKVTFTSNGDNQSGTHDSQSTSTEIEIVTTSSTKVLPPVVSSNTDLTSEPTNTREQPTTLSTTSNSITEDITTSQPTGDNGDNTSSTNPVPTVATSTLASASEEDNKSGSHESASTSLKPSMGENSGLTTSTEIEATTTSPTEAPSPAVSSGTDVTTEPTDTREQPTTLSTTSKTNSESVATTQATNENGGKSPSTDLTSSLTTGTSASTSANSELVTSGSVTGGAVASASNDQSHSTSVTNSNSIVSNTPQTTLSQQVTSSSPSTNTFIASTYDGSGSIIQHSTWLYGLITLLSLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5A927</accession>
    <name>Q5A927_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N,N-dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C101190CA</name>
        <name evidence="5" type="ordered locus">orf19.10817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718130.1">
        <property type="nucleotide sequence ID" value="XM_713037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5A927"/>
    <dbReference type="SMR" id="Q5A927"/>
    <dbReference type="FunCoup" id="Q5A927">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="GeneID" id="3640207"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101190CA"/>
    <dbReference type="CGD" id="CAL0000179574">
        <property type="gene designation" value="orf19.10817"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01190C_A"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="InParanoid" id="Q5A927"/>
    <dbReference type="OMA" id="MVTPLWK"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000179574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW25814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="463" mass="53072" checksum="5756F07450AD6911" modified="2005-04-26" version="1">MTKEQIDEPRYKRIAVIGGGPTGLAAVKALSLEPVNFSCIDLFERRDRLGGLWYHHGDKSLVKPEIPSLSPSQEEIVSDNATPADEYFSAIYEYMETNIVHQIMEYSGVAFPANSKKYPTRSQVLEYIDDYIKSIPKDTVNISINSNVVSLEKVNEIWHIEIEDVIKKTRAKLRYDAVIIANGHFSNPYIPDVPGLSSWNKNYPGTITHSKYYESPAKFRDKRVLVVGNSASGVDISIQLSVCAKDVFVSIRDQESPHFEDGFCKHIGLIEEYNYETRSVRTTDREVVSDIDYVIFCTGYLYALPFLKQERNITDGFQVYDLYKQIFNIYDPSLTFLALLRDVIPMPISESQAALIARVYSGRYKLPPTEEMERYYQLELKEKGRGGKFHNYKYPRDVAYCQMLQTLIDEQGLHTPGLVAPIWDESLIKKRSETRAEKNARLKNVVEHVKRLRAEGKDFSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABE0</accession>
    <name>Q5ABE0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C100760WA</name>
        <name evidence="2" type="ordered locus">orf19.13451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718992.1">
        <property type="nucleotide sequence ID" value="XM_713899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABE0"/>
    <dbReference type="SMR" id="Q5ABE0"/>
    <dbReference type="GeneID" id="3639351"/>
    <dbReference type="KEGG" id="cal:CAALFM_C100760WA"/>
    <dbReference type="CGD" id="CAL0000195596">
        <property type="gene designation" value="orf19.13451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_00760W_A"/>
    <dbReference type="HOGENOM" id="CLU_1266708_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ABE0"/>
    <dbReference type="OrthoDB" id="10333398at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000195596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="219" mass="24404" checksum="2033F280501CB5B1" modified="2005-04-26" version="1">MNRTCMSIAYLLDTLPTDQNTPPPPPRNILTEISNMNDNAGVNNSSESSVVTSISNTNQSVTVGSSYNPESDDYVHDREGFKRRIERLDETFVDLTSRENPSEEDTNRNIGKNGSPVKKKIKRDEEILNLLSSPPKQGSSRDSLGSSKLKERNVAKTKKIESQASIEFKEIVQSLIELGSEIDAKGLDTHPDIDKILESLSAIRMDFLHMLTNKKNLAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABT8</accession>
    <accession>A0A1D8PQ41</accession>
    <accession>Q5AC62</accession>
    <name>BMT4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Beta-mannosyltransferase 4</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>WRY family protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">BMT4</name>
        <name type="synonym">WRY1</name>
        <name type="ordered locus">CAALFM_C603250WA</name>
        <name type="ORF">CaO19.13055</name>
        <name type="ORF">CaO19.5612</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="57" first="1318" last="1341">
            <title>The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis in Candida albicans.</title>
            <authorList>
                <person name="Urban C."/>
                <person name="Xiong X."/>
                <person name="Sohn K."/>
                <person name="Schroppel K."/>
                <person name="Brunner H."/>
                <person name="Rupp S."/>
            </authorList>
            <dbReference type="PubMed" id="16102003"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04771.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="J. Biol. Chem." volume="283" first="9724" last="9736">
            <title>Identification of a new family of genes involved in beta-1,2-mannosylation of glycans in Pichia pastoris and Candida albicans.</title>
            <authorList>
                <person name="Mille C."/>
                <person name="Bobrowicz P."/>
                <person name="Trinel P.A."/>
                <person name="Li H."/>
                <person name="Maes E."/>
                <person name="Guerardel Y."/>
                <person name="Fradin C."/>
                <person name="Martinez-Esparza M."/>
                <person name="Davidson R.C."/>
                <person name="Janbon G."/>
                <person name="Poulain D."/>
                <person name="Wildt S."/>
            </authorList>
            <dbReference type="PubMed" id="18234669"/>
            <dbReference type="DOI" id="10.1074/jbc.M708825200"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 5">Expression in regulated by TSA1 and repressed in rat catheter biofilm.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719173.2">
        <property type="nucleotide sequence ID" value="XM_714080.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABT8"/>
    <dbReference type="SMR" id="Q5ABT8"/>
    <dbReference type="STRING" id="237561.Q5ABT8"/>
    <dbReference type="CAZy" id="GT91">
        <property type="family name" value="Glycosyltransferase Family 91"/>
    </dbReference>
    <dbReference type="GeneID" id="3639182"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603250WA"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013841_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ABT8"/>
    <dbReference type="OrthoDB" id="3631276at2759"/>
    <dbReference type="PRO" id="PR:Q5ABT8"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000426072" description="Beta-mannosyltransferase 4">
        <location>
            <begin position="1"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="39"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16102003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18234669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21414038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="781" mass="90959" checksum="82B47D1C6123C4E2" modified="2017-04-12" version="2">MTKSYMPLFRSPRQFKKIYFILIPLILAVIILHVFFDGFNKISEYSPTFISNRILNHQDQQQKSEKSSDVISSYFPSLAIYPKNFDNRVEFVNEPKNSKWIQYFGDSKTVLSNYITNQTYTNHSIGLYSSSTVRPPASSCKDILYERSFEITKYRTLHDDLYKLATTLLYQLENDPAFQDLSPFFNDRLPHIIMRGELHKHIYKFAGTSVWLEQHGVHLMLSRVIYSQQGKKNDPQLSLLYAQVYDENWNELNDIELIVPVINPNGERVYDSVKYPQFLAIPFYHNSEYIKSRWYGPEDTRLILTKNKFGDDEPVIIFNSYHRQIKDMSTEDDNNVHTKFEFYRSMFVGWLFQYQLGKLNTDGIQDSKFNNVTFNKVKELRIEGKERTSIEKNWTPFIDPDERNQISYYGNHNLGDNYVYIVYQWNHLKILKCELDNFIDSSHSTCTMFFKDVETTQEVGPVRGGTELWPIKIDNNNNNNNLNEDDLSTKQEPQQQRQLWIGFLRAHVKDCGCGGSMYRPNFLILEKLNSKFKLTYLSGSINFNVSVYGWANYDVVCAGHEANALIPNGISMFDQDDDYLTLSMSVADQDNTLVHIHGVKKLIYSLDHDWNGILKENKQIECVVNNANDFCKAYADEHYKLGDSEAAIKEVKQKAKEEAEKAKAEKEKAEKEKAEKEKAEKEKEEKEKEEKEEKEKAEKEKEEKEKAEKELAEKELAEQKDEDAKDEDKNEDEDDKEKNDESGLTEKSEVEENGENTNEGGEDDGDGDGEEEKEDDDDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ABU1</accession>
    <name>Q5ABU1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C603220WA</name>
        <name evidence="3" type="ordered locus">orf19.13052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719170.1">
        <property type="nucleotide sequence ID" value="XM_714077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ABU1"/>
    <dbReference type="SMR" id="Q5ABU1"/>
    <dbReference type="GeneID" id="3639179"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603220WA"/>
    <dbReference type="CGD" id="CAL0000188314">
        <property type="gene designation" value="orf19.13052"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03220W_A"/>
    <dbReference type="eggNOG" id="ENOG502T3ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077445_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ABU1"/>
    <dbReference type="OMA" id="QIFNHSE"/>
    <dbReference type="OrthoDB" id="4026228at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000188314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW30252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="361" mass="41791" checksum="C1FBB0E81EB0038B" modified="2005-04-26" version="1">MNIEAEDDDDLLNELDHELKNTQTSKVSFKKKSFNKPQKIQRNKLSFNIDDEEEDEEKEGHDGEKNNINELKPVPSKGASLLRFNPRTKFTKEKSSETEQPVKKPINLSRYQIDTKTTTTTDNADQEIIPFELDEEDPENNPVITNIDDLNDEDNEEFAKLKSKLIATTTTSQIFNHSEVLTSANKDTPKRYVPIETNRVPESSKLSIRQYTKALVNEYKDDKNYDDGTERQNQEDQDLLLHDINDGDIELNDEDMGILNIGKRANFDDNKFNFEIHSDDDDEKEESDDRLHSENESNDNGNIDFRIPTVEEQIMKINGLIKQLEVTKSEKQKLVQNLKIERDELTETKSELLEKLNNLVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-11-13" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AC08</accession>
    <accession>A0A1D8PPY9</accession>
    <accession>Q5ACC9</accession>
    <name>CARP6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Secreted aspartic protease 6</fullName>
            <shortName evidence="19">ACP 6</shortName>
            <shortName evidence="19">Aspartate protease 6</shortName>
            <ecNumber evidence="12 17">3.4.23.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Candidapepsin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SAP6</name>
        <name type="ordered locus">CAALFM_C602710CA</name>
        <name type="ORF">CaO19.12988</name>
        <name type="ORF">CaO19.5542</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <scope>GENOME REANNOTATION</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
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        <scope>IDENTIFICATION</scope>
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        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
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        </citation>
        <scope>FUNCTION</scope>
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        <scope>FUNCTION</scope>
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            <dbReference type="PubMed" id="12065511"/>
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        <scope>FUNCTION</scope>
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            <dbReference type="PubMed" id="21646240"/>
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        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
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        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
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                <person name="Ramage G."/>
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            <dbReference type="PubMed" id="22302440"/>
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        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="12">
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            <dbReference type="PubMed" id="23484407"/>
        </citation>
        <scope>INDUCTION</scope>
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            <title>Pathogen and host factors are needed to provoke a systemic host response to gastrointestinal infection of Drosophila larvae by Candida albicans.</title>
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            <dbReference type="PubMed" id="21540243"/>
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        </citation>
        <scope>FUNCTION</scope>
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            </authorList>
            <dbReference type="PubMed" id="23927842"/>
            <dbReference type="DOI" id="10.1016/j.peptides.2013.07.023"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="15">
        <citation type="journal article" date="2013" name="Biochem. Pharmacol." volume="85" first="881" last="887">
            <title>Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans.</title>
            <authorList>
                <person name="Cadicamo C.D."/>
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                <person name="Borelli C."/>
            </authorList>
            <dbReference type="PubMed" id="23262278"/>
            <dbReference type="DOI" id="10.1016/j.bcp.2012.12.008"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8 9 10 11 13 16">Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:12065511, PubMed:17652724, PubMed:20713630, PubMed:21540243, PubMed:22302440). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (PubMed:11478679, PubMed:12065511, PubMed:17652724, PubMed:20713630, PubMed:21540243, PubMed:22302440). Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein (PubMed:23927842).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Inhibited by pepstatin A analogs.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="12 17">Optimum pH is 5.0.</text>
        </phDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="13 15">Expressed during development of germ tubes, pseudohyphae and true hyphae (PubMed:23484407). Expressed in greater amounts in the mature biofilms compared to early biofilms during inflammatory disorder of the palatal mucosa among denture wearers (PubMed:22302440).</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="12 17"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719105.1">
        <property type="nucleotide sequence ID" value="XM_714012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AC08"/>
    <dbReference type="SMR" id="Q5AC08"/>
    <dbReference type="STRING" id="237561.Q5AC08"/>
    <dbReference type="MEROPS" id="A01.064"/>
    <dbReference type="GlyCosmos" id="Q5AC08">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_02710C_A-T">
        <property type="protein sequence ID" value="C6_02710C_A-T-p1"/>
        <property type="gene ID" value="C6_02710C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639229"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602710CA"/>
    <dbReference type="CGD" id="CAL0000179762">
        <property type="gene designation" value="SAP6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02710C_A"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="Q5AC08"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="BRENDA" id="3.4.23.24">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:10193"/>
    <dbReference type="PHI-base" id="PHI:6788"/>
    <dbReference type="PHI-base" id="PHI:6794"/>
    <dbReference type="PHI-base" id="PHI:6809"/>
    <dbReference type="PHI-base" id="PHI:6816"/>
    <dbReference type="PRO" id="PR:Q5AC08"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031505">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
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    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000023">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000424298" description="Activation peptide" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000424299" description="Secreted aspartic protease 6">
        <location>
            <begin position="77"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>pepstatin A</name>
            <dbReference type="ChEBI" id="CHEBI:190525"/>
            <note>inhibitor</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="332"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0CY27"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P0CY29"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="11478679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="12065511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="17652724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="20713630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="21540243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="21646240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="22302440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="23262278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="15">
        <source>
            <dbReference type="PubMed" id="23484407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="16">
        <source>
            <dbReference type="PubMed" id="23927842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="17">
        <source>
            <dbReference type="PubMed" id="9043112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="18">
        <source>
            <dbReference type="PubMed" id="7984113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="19"/>
    <sequence length="418" mass="45432" checksum="8ED0F1C0240FF989" modified="2005-04-26" version="1" precursor="true">MLLKNILSVLAFALLIDAAPVKRSPGFVTLDFNVKRSLVDPDDPTVESKRSPLFLDLDPTKIPVDDTGRNDGVDKRGPVAVKLDNEIITYSADITVGSNNQKLSVIVDTGSSDLWIPDSKAICIPKWRGDRGDFCKNNGSYSPAASSTSKNLNTRFEIKYADGSYAKGNLYQDTVGIGGASVKNQLFANVWSTSAHKGILGIGFQANEATRTPYDNLPISLKKQGIIAKNAYSLFLNSPEASSGQIIFGGIDKAKYSGSLVELPITSDRTLSVGLRSVNVMGRNVNVNAGVLLDSGTTISYFTPSIARSIIYALGGQVHFDSAGNKAYVADCKTSGTVDFQFDKNLKISVPASEFLYQLYYTNGKPYPKCEIRVRESEDNILGDNFMRSAYIVYDLDDKKISMAQVKYTSESNIVAIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ACU6</accession>
    <accession>A0A1D8PU15</accession>
    <name>RRP3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RRP3</name>
        <name type="ordered locus">CAALFM_CR09740WA</name>
        <name type="ORF">CaO19.7546</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="patent" date="2004-06-08" number="US6747137">
            <title>Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics.</title>
            <authorList>
                <person name="Weinstock K.G."/>
                <person name="Bush D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AR550432">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719308.2">
        <property type="nucleotide sequence ID" value="XM_714215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ACU6"/>
    <dbReference type="SMR" id="Q5ACU6"/>
    <dbReference type="FunCoup" id="Q5ACU6">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ACU6"/>
    <dbReference type="EnsemblFungi" id="CR_09740W_A-T">
        <property type="protein sequence ID" value="CR_09740W_A-T-p1"/>
        <property type="gene ID" value="CR_09740W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3639008"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR09740WA"/>
    <dbReference type="CGD" id="CAL0000176052">
        <property type="gene designation" value="orf19.7546"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_09740W_A"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ACU6"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232270" description="ATP-dependent rRNA helicase RRP3">
        <location>
            <begin position="1"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="149"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="347"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box" evidence="5">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="162"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="534" mass="59792" checksum="AAE61037DB03EEB6" modified="2017-04-12" version="3">MTMMNEKLKKEKKKIFGVITPFQKYLYTPRIINTVHLIIMSSKGITKKKVKSLKNLDSTKKLAEKIKQQALQKQQKQQKQQEQENANHNQTESSLSSSSSTTSSSITTIDPDAELKFKTFKELNLVPDLLESIESMKFTKPTPIQSEAIPHALEGKDIIGLAQTGSGKTAAFAIPILQSLWHAQQPYFALVLAPTRELAFQIKDTFDALGSSMGLRSSCIVGGMDMMDQARDLMRKPHVIVATPGRIMDHLEHTKGFSLKNLKYLVMDEADRLLDMDFGPALDKILKVIPIKRTTYLFSATMTNKIEKLQRASLHNPVRVAVSSKYQTADNLVQSMMLVNDGYKNTILIHLLNEFMGKSIIVFTRTVAHAQRTALLARILGFNAVPLHGQLSQSQRLGSLNKFKSNQANILVATDVAARGLDIPSVDVVINYDIPTDSKAYIHRVGRTARAGRSGKSISLITQYDLEMYLRIESVLGKKLPKEDKPPKEVLDALHVHVDKATAEAIRQTKEIHDKRNGGGGRRRNRDDADREER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-04-16" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AD56</accession>
    <accession>A0A1D8PG97</accession>
    <accession>Q5ADI5</accession>
    <name>NOT3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>General negative regulator of transcription subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NOT3</name>
        <name type="synonym">NOT31</name>
        <name type="ordered locus">CAALFM_C201130WA</name>
        <name type="ORF">CaO19.2012</name>
        <name type="ORF">CaO19.9563</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Infect. Immun." volume="71" first="6101" last="6103">
            <title>Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus.</title>
            <authorList>
                <person name="Cheng S."/>
                <person name="Nguyen M.H."/>
                <person name="Zhang Z."/>
                <person name="Jia H."/>
                <person name="Handfield M."/>
                <person name="Clancy C.J."/>
            </authorList>
            <dbReference type="PubMed" id="14500538"/>
            <dbReference type="DOI" id="10.1128/IAI.71.10.6101-6103.2003"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1002525" last="E1002525">
            <title>Portrait of Candida albicans adherence regulators.</title>
            <authorList>
                <person name="Finkel J.S."/>
                <person name="Xu W."/>
                <person name="Huang D."/>
                <person name="Hill E.M."/>
                <person name="Desai J.V."/>
                <person name="Woolford C.A."/>
                <person name="Nett J.E."/>
                <person name="Taff H."/>
                <person name="Norice C.T."/>
                <person name="Andes D.R."/>
                <person name="Lanni F."/>
                <person name="Mitchell A.P."/>
            </authorList>
            <dbReference type="PubMed" id="22359502"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1002525"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4 5">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Required for yeast cell adherence to silicone substrate, but nor required not required for buccal epithelial cell adherence or virulence in mouse systemic infection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOT protein complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Decreases cell adherence to silicone substrate. Decreases slightly filamentation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CNOT2/3/5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW27161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475200.1"/>
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        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AD56"/>
    <dbReference type="EnsemblFungi" id="C2_01130W_A-T">
        <property type="protein sequence ID" value="C2_01130W_A-T-p1"/>
        <property type="gene ID" value="C2_01130W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3638829"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201130WA"/>
    <dbReference type="CGD" id="CAL0000179957">
        <property type="gene designation" value="NOT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01130W_A"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020483_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AD56"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="PRO" id="PR:Q5AD56"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900189">
        <property type="term" value="P:positive regulation of cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000426088" description="General negative regulator of transcription subunit 3">
        <location>
            <begin position="1"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="14500538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22359502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="752" mass="85707" checksum="7BF3D442F20C4D6F" modified="2017-05-10" version="2">MSNRKLQKEIDIIFKKIQEGLQDFDYHYERYESIQNTEDDSDNQREKEKLANDLKKEIKKLQKFREQIKHWLQNDTVHTLGPVGTSYESKLAENKSLIEDSMETYKLVEKQSKLKTFSNQSIMMTFMDSTNGDDDDDDDDSDDDELFSGSDEDEEDEYSDLPEDAVNAIHFFKDSILQLREQTHKLDHEYEKLAAKKLRKNNLATIEAKKEKIQSTIGNNKFHQKKLKKLLRQLTSGVVTEFNLIWLLKDDLNKYLESNGDYEFTRETELYDDIFNQIAAVEEDYSEIHEDNHDHSHSHLEKTSTANGTHHESATTTATAAKNSSVTTRTSPSPILTKANGHIKELSVESGSPTTSRSKLSKIHTNTSQSSTHSNTSSSTHAQAPRQSPELTSPAIVKTLRPATAPSKPVGTLKWSAAAAAAIPDVQEKPELVETESNGSSVHKTVSKDQYEEKINYQSPAPTQQQQQPQTSVESKTLSTTQSLASSITDNINLDKYKEVIKNSNLTKTELGLFSDMNLARVPPGIQDLVISFASKRNNDNFKVLVDSTEFNQFALPLHKPYLPEIVQPSYYSQYTSTSFKHPTPLVKFQSYWNQVRANFGFQKLMDEIKSLTLQNNADNLPIIAELTFVLFYGFYYGVTPAENLIAESYLFELGWKPYKNQSEDGSNNLSTGSISLSDINGSKSKSNRSSNYYFWFKRVKLISRGEDMGQPSNIEFGDYQVFDLSFWEIFVKYGFKFDYNFCQMEPSKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ADP5</accession>
    <name>Q5ADP5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribose diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">YSA1</name>
        <name evidence="4" type="ordered locus">CAALFM_C307040CA</name>
        <name evidence="3" type="ordered locus">orf19.14088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719892.1">
        <property type="nucleotide sequence ID" value="XM_714799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ADP5"/>
    <dbReference type="SMR" id="Q5ADP5"/>
    <dbReference type="FunCoup" id="Q5ADP5">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5ADP5"/>
    <dbReference type="GeneID" id="3638516"/>
    <dbReference type="KEGG" id="cal:CAALFM_C307040CA"/>
    <dbReference type="CGD" id="CAL0000184863">
        <property type="gene designation" value="YSA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_07040C_A"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ADP5"/>
    <dbReference type="OMA" id="KWEMVQR"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADP-ribose diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000184863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="233" mass="26155" checksum="AA2318F4684B3A1A" modified="2005-04-26" version="1">MFKQLFKPTTTTTTTTTLIKRFMSASTPIKNSPFKAKVTSIEPLTNGKWIQTKKINYDDPNGNSRVWEMAIRTTRSTTTNIDAVSIVSILHNHANDSKEIVLVKQFRPPTEQVVIELPAGLIDPNESIESTAIRELIEETGYYGTFKSQSIPIFSDPGLTNANMVLAYVDVDLNDPKNQSPQPKLEPGEFIITFTLPLNNLLHSLEEICEKENCTIDARLYHFAKGLELAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AEE2</accession>
    <name>Q5AEE2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAALFM_C303270WA</name>
        <name evidence="5" type="ordered locus">orf19.7958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720021.1">
        <property type="nucleotide sequence ID" value="XM_714928.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AEE2"/>
    <dbReference type="SMR" id="Q5AEE2"/>
    <dbReference type="STRING" id="237561.Q5AEE2"/>
    <dbReference type="GeneID" id="3638321"/>
    <dbReference type="KEGG" id="cal:CAALFM_C303270WA"/>
    <dbReference type="CGD" id="CAL0000195675">
        <property type="gene designation" value="orf19.7958"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_03270W_A"/>
    <dbReference type="eggNOG" id="KOG3335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074707_3_2_1"/>
    <dbReference type="InParanoid" id="Q5AEE2"/>
    <dbReference type="OMA" id="WAEFEGT"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000195675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17173" checksum="E9FABA8E4E79D12F" modified="2005-04-26" version="1">MSGLALKFTSLLVRTIAKPIGNAIKRQAKDHERFRRLCINFAQKMHSSEIKLRMSLLGENKIKVKPLNDNKAIEQGATFISEFFIFSVAGSLIFYESYRSRKKATSERDALADDITLLQSEMEKIKNKLEDINVKLVDYKVSESPSETATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AG89</accession>
    <name>Q5AG89_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">TRR1</name>
        <name evidence="12" type="ordered locus">CAALFM_C502710WA</name>
        <name evidence="11" type="ordered locus">orf19.11766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP017627">
        <property type="protein sequence ID" value="AOW29696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720598.1">
        <property type="nucleotide sequence ID" value="XM_715505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AG89"/>
    <dbReference type="SMR" id="Q5AG89"/>
    <dbReference type="FunCoup" id="Q5AG89">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AG89"/>
    <dbReference type="GeneID" id="3637778"/>
    <dbReference type="KEGG" id="cal:CAALFM_C502710WA"/>
    <dbReference type="CGD" id="CAL0000184081">
        <property type="gene designation" value="TRR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C5_02710W_A"/>
    <dbReference type="eggNOG" id="KOG0404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="InParanoid" id="Q5AG89"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000184081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW29696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="320" mass="34683" checksum="8F5D44BE33101F36" modified="2005-04-26" version="1">MVHHKVTIIGSGPAAHTAAIYLARAEIKPTLYEGMLANGIAAGGQLTTTTDIENFPGFPNGIGGSELMEKMKEQSQRFGTEIITETISKVDFSKRPFKLWTEWNEDAEPITTDAVIIATGASAKRMHLPGEDTYWQQGISACAVCDGAVPIFRNNPLAVIGGGDSACEEAIFLTKYASKVFLLVRRDVLRASTIMQKRVTNNEKIEVLWNTEALEAKGDGKLLKSLRIVNNKTKEEKDLQVNGLFYAIGHIPATKIFADQLKTDEAGYIQTTPGTASTSIEGVFAAGDVQDKIYRQAITSAGSGCMAALECEKFISEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH06</accession>
    <accession>Q3MPF5</accession>
    <name>Q5AH06_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">CAALFM_C701880CA</name>
        <name evidence="15" type="ordered locus">orf19.13885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721370.1">
        <property type="nucleotide sequence ID" value="XM_716277.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH06"/>
    <dbReference type="SMR" id="Q5AH06"/>
    <dbReference type="FunCoup" id="Q5AH06">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AH06"/>
    <dbReference type="GeneID" id="3637031"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701880CA"/>
    <dbReference type="CGD" id="CAL0000191717">
        <property type="gene designation" value="orf19.13885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01880C_A"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="InParanoid" id="Q5AH06"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008517">
        <property type="term" value="F:folic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="125"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="229"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000191717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW30552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="316" mass="35559" checksum="2B884667BE407597" modified="2005-04-26" version="1">MELNTTDKQVHTRRFSSREIEVISGLLAGFSTTIVTHPLDVIKIRLQLSRDTPKTTHPLESIISVIKKINQDAKVAYKLNHKPKAFNYLIQYYRGITPNLIGNISAWGIYFALYAEFKSKVKTNNTTMNYFASSVLAGLSTSIITNPLWVLKTRILGSSRNESNAYRSVTDGIRQMLAKEGITSFWKGTIPSLFSVVQASLQITIYDHIKVYLSSPHHKSESIGATSHLSTWQYLYSSASSKIISMLILYPTQVVRSRLQYSQDSSSSIVSIVKELYYKEGGLKGFYKGIGANILRVLPATCVTFVAYENVKRYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AH99</accession>
    <name>Q5AH99_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ESCRT-III subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">VPS20</name>
        <name evidence="10" type="ordered locus">CAALFM_C203310CA</name>
        <name evidence="9" type="ordered locus">orf19.8516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721018.1">
        <property type="nucleotide sequence ID" value="XM_715925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AH99"/>
    <dbReference type="SMR" id="Q5AH99"/>
    <dbReference type="FunCoup" id="Q5AH99">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AH99"/>
    <dbReference type="GeneID" id="3637427"/>
    <dbReference type="KEGG" id="cal:CAALFM_C203310CA"/>
    <dbReference type="CGD" id="CAL0000174239">
        <property type="gene designation" value="VPS20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_03310C_A"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086201_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AH99"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071285">
        <property type="term" value="P:cellular response to lithium ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036178">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to neutral pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036177">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000174239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW27367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="216" mass="25001" checksum="9569C9A2F115A344" modified="2005-04-26" version="1">MGQQPSTPKITAQDRAIFQLKQQRDKLKQYQKRLNTIIEKQTELAKKAVLNKQPEKAKFYLRSKKQQESVISTTFDQLNNLEKLIGTIEFKLIEKDVVYGLQQGNKVLQKLNNEMQVEKIDALIDQLEDEKLKVDEVSELLGGVDQLNRSEEDEVDKEFQTLQEEIHGKIKQVTEEEEEESNLPKVPNTKPMPEAPSNEIEEHTPQKETKHEPIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI35</accession>
    <name>Q5AI35_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Spp1p</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="11" type="ordered locus">CAALFM_C103250CA</name>
        <name evidence="10" type="ordered locus">orf19.10536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721516.1">
        <property type="nucleotide sequence ID" value="XM_716423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AI35"/>
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    <dbReference type="FunCoup" id="Q5AI35">
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    </dbReference>
    <dbReference type="STRING" id="237561.Q5AI35"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG1632">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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    </feature>
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <sequence length="406" mass="47177" checksum="132AFD8F4EF4F286" modified="2005-04-26" version="1">MDPDTTQYDKVKGEWSENSIDIKSNLKRSKPSHSIPSKRVKHDVDSSPLVEESNEEIARQYKKFINAPKYDLNSEELFCVCRRPDLGEMMVACDGCEEWFHFKCMKINEKYSNLIAKYYCKFCEWKGEGNSQWKRKCRLENCNEPIGERSKYCSKEHGIEFIKSSLLESKTNSTDSPSLQNLDAHFIKDVLNYVSGDFDKLQQMGSSFPELEVVKNYKNDNTALDGFPETVKIDLQRTNEKLDALSKQVTKQEQVLKALVNTKDNIKHLNERLTNIVYEDSSSDKQTSKKKKGARGKKKIDICFCDKGDQSIVQSITDSETIFDDLLKVIKARVFENGEAEEEDMDWFMNDLCIKDKKKCVRHSGWWNLYYDEAGRNLEQLQSKLEETMEQKESILRNYSISVYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AI87</accession>
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        <submittedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
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        <name evidence="2" type="ordered locus">orf19.10483</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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                <person name="Scherer S."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Martchenko M."/>
                <person name="Grindle S."/>
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                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="237561.Q5AI87"/>
    <dbReference type="ESTHER" id="canal-q5ai87">
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000182185"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
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    </evidence>
    <sequence length="252" mass="28382" checksum="C3A960F0ABD162F9" modified="2005-04-26" version="1">MRIYVYHPKIPNYPKVKFPGVLVYSEIYQVTGPVSRFAKDIAGQGFIVACPSSYHNFVGPEPLAYDVEGTDIGNQYKIEKELKSYDEDTNLTIEYLLSLPTCNGKLGATGMCLGGHLAYRAALDPRVQATVCFFATDIHSKSLGKGKNDDSLERCGEIKGEIILIFGCKDNHVPLEGRDLIRGELRKKNVEMTFIEINDAQHAFVRDELSKGRYDPATTKLCFEWLFELFNRKLKLDYGDHDGKDVVIENVC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
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        <alternativeName>
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    <gene>
        <name type="primary">RPS7A</name>
        <name type="ordered locus">orf19.1700</name>
        <name type="ORF">CAALFM_C301490WA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPS7A is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721772.1">
        <property type="nucleotide sequence ID" value="XM_716679.2"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
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        <property type="resolution" value="2.64 A"/>
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    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="I=1-186"/>
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    <dbReference type="PDB" id="7Q0R">
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        <property type="resolution" value="2.67 A"/>
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        <property type="resolution" value="2.90 A"/>
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        <property type="resolution" value="3.50 A"/>
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        <property type="resolution" value="2.15 A"/>
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    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
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    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="Q5AJ93"/>
    <dbReference type="EMDB" id="EMD-13737"/>
    <dbReference type="EMDB" id="EMD-13741"/>
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    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="Q5AJ93"/>
    <dbReference type="FunCoup" id="Q5AJ93">
        <property type="interactions" value="1239"/>
    </dbReference>
    <dbReference type="STRING" id="237561.Q5AJ93"/>
    <dbReference type="EnsemblFungi" id="C3_01490W_A-T">
        <property type="protein sequence ID" value="C3_01490W_A-T-p1"/>
        <property type="gene ID" value="C3_01490W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3636573"/>
    <dbReference type="KEGG" id="cal:CAALFM_C301490WA"/>
    <dbReference type="CGD" id="CAL0000199878">
        <property type="gene designation" value="RPS7A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_01490W_A"/>
    <dbReference type="eggNOG" id="KOG3320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AJ93"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456545" description="Small ribosomal subunit protein eS7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P26786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW28191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="186" mass="21247" checksum="DE472A1A4D42A5D7" modified="2005-04-26" version="1">MSSKILSENPTELELKVAQAFVDLESQADLKAELRPLQFKSIKEIDVNGGKKALAVFVPPPSLQAYRKVQTRLTRELEKKFPDRHVVFLAERRILPKPARKARKQQKRPRSRTLTAVHDKILEDLVFPTEIIGKRVRYLVGGNKIQKVLLDSKDSTAVDYKLDSFQQLYSKLTGKQVVFEIPGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AKX8</accession>
    <name>Q5AKX8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">CYB2</name>
        <name evidence="26" type="ordered locus">CAALFM_C113630WA</name>
        <name evidence="25" type="ordered locus">orf19.12467</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722204.1">
        <property type="nucleotide sequence ID" value="XM_717111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AKX8"/>
    <dbReference type="SMR" id="Q5AKX8"/>
    <dbReference type="FunCoup" id="Q5AKX8">
        <property type="interactions" value="358"/>
    </dbReference>
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<entry dataset="Swiss-Prot" created="2014-04-16" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AL16</accession>
    <accession>A0A1D8PFM6</accession>
    <name>STP2_CANAL</name>
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        <recommendedName>
            <fullName>Transcriptional regulator STP2</fullName>
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        <name type="primary">STP2</name>
        <name type="ordered locus">CAALFM_C113350WA</name>
        <name type="ORF">CaO19.12426</name>
        <name type="ORF">CaO19.4961</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E27434" last="E27434">
            <title>Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans.</title>
            <authorList>
                <person name="Davis M.M."/>
                <person name="Alvarez F.J."/>
                <person name="Ryman K."/>
                <person name="Holm A.A."/>
                <person name="Ljungdahl P.O."/>
                <person name="Engstrom Y."/>
            </authorList>
            <dbReference type="PubMed" id="22110651"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0027434"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="9435" last="9446">
            <title>Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control.</title>
            <authorList>
                <person name="Martinez P."/>
                <person name="Ljungdahl P.O."/>
            </authorList>
            <dbReference type="PubMed" id="16227594"/>
            <dbReference type="DOI" id="10.1128/MCB.25.21.9435-9446.2005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PROTEOLYTIC PROCESSING</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="MBio" volume="2" first="E00055" last="E00055">
            <title>The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH.</title>
            <authorList>
                <person name="Vylkova S."/>
                <person name="Carman A.J."/>
                <person name="Danhof H.A."/>
                <person name="Collette J.R."/>
                <person name="Zhou H."/>
                <person name="Lorenz M.C."/>
            </authorList>
            <dbReference type="PubMed" id="21586647"/>
            <dbReference type="DOI" id="10.1128/mBio.00055-11"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Curr. Biol." volume="22" first="461" last="470">
            <title>Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise.</title>
            <authorList>
                <person name="Shapiro R.S."/>
                <person name="Sellam A."/>
                <person name="Tebbji F."/>
                <person name="Whiteway M."/>
                <person name="Nantel A."/>
                <person name="Cowen L.E."/>
            </authorList>
            <dbReference type="PubMed" id="22365851"/>
            <dbReference type="DOI" id="10.1016/j.cub.2012.01.062"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="Eukaryot. Cell" volume="12" first="1281" last="1292">
            <title>Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death.</title>
            <authorList>
                <person name="Langford M.L."/>
                <person name="Hargarten J.C."/>
                <person name="Patefield K.D."/>
                <person name="Marta E."/>
                <person name="Blankenship J.R."/>
                <person name="Fanning S."/>
                <person name="Nickerson K.W."/>
                <person name="Atkin A.L."/>
            </authorList>
            <dbReference type="PubMed" id="23873867"/>
            <dbReference type="DOI" id="10.1128/EC.00311-12"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyphal form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Proteolytically cleaved: activated by the amino acid-induced proteolytic removal of an N-terminal inhibitory domain.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 7 8">Exhibits reduced capacity to take up amino acids and to switch to the hyphal form, and impairs response to farnesol.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_717078.2"/>
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        <property type="protein sequence ID" value="C1_13350W_A-T-p1"/>
        <property type="gene ID" value="C1_13350W_A"/>
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        <property type="gene designation" value="STP2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:amino acid import"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_0000426056">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000426057" description="Transcriptional regulator STP2">
        <location>
            <begin status="unknown"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="381"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
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    </feature>
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        <location>
            <begin position="203"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="394"/>
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    </feature>
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        <location>
            <begin position="431"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16227594"/>
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            <dbReference type="PubMed" id="22365851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="23873867"/>
        </source>
    </evidence>
    <sequence length="584" mass="67011" checksum="4CF132637C6523BA" modified="2005-04-26" version="1" precursor="true">MSVAITSNNNKQPQPQPQPHLKVVNNNSTFNLYTWLRSVFQYCISLIISYTSNWLLVNNDNNNNNININYKSNNNDNNNASTSLQPKISNVKAESMKIFPDLQKSNFTTYYTTEKPLHQDVLKPVICSTGITSRILPYTNEKGELEWKFTEVQGKELDEFKMHPQQQQQQQEVKQELSPAESNESNESLAKDSSTTPASISDSPSHSETESTVSSTIIANSNQIFKCPSCDAEFRVRGYLTRHMKKHSTKKAYTCPFHDKSIYVDENNITHKCHSSGGFSRRDTYKTHLKSRHFNYAKPIKSAERSKVPGQCAMCGEHFNSAEIWCEIHVEGGECKFLPMGFKGKSRIKNRLKKQIQKNKMIDPELVPFASKVLEEVEQERQKKKNYRTTGTGSESSIQSQESESSINSTPLSMQISAPVPMPVSIQQQHQHQHQHHHHVQNQHQQHVNQQQSIATPASIYSSSASSTSSYESTHSPYTPQSSRSPLSHMYNPQQPPYFNQIAQAHQQDGQKNQVKDDYDDEYCLDVDQLNTTFVNETVANYLQIHDFHSMNQYQPGQQQQQQQQQQQQQQQRQHQQQQPSMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ALY5</accession>
    <name>Q5ALY5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NRI1</name>
        <name evidence="3" type="ordered locus">CAALFM_C201370CA</name>
        <name evidence="2" type="ordered locus">orf19.9016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722491.1">
        <property type="nucleotide sequence ID" value="XM_717398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ALY5"/>
    <dbReference type="STRING" id="237561.Q5ALY5"/>
    <dbReference type="GeneID" id="3635723"/>
    <dbReference type="KEGG" id="cal:CAALFM_C201370CA"/>
    <dbReference type="CGD" id="CAL0000198983">
        <property type="gene designation" value="NRI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_01370C_A"/>
    <dbReference type="eggNOG" id="ENOG502QQIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027733_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ALY5"/>
    <dbReference type="OMA" id="PFNYEAE"/>
    <dbReference type="OrthoDB" id="4084568at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053110">
        <property type="entry name" value="Ribosomal_L1-TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162:SF1">
        <property type="entry name" value="RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN CG13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48162">
        <property type="entry name" value="YALI0A06930P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000198983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW27183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="618" mass="72348" checksum="BBA1AEC568A37624" modified="2005-04-26" version="1">MDVRRCRRCKRKRLDDEPDEVRQYKTCAKCRIIERNKKNSRKPLAEETMLYGLKQFREQQSAENYIEEEGLLKDEFFKRYHNKPFNYQEEITKVLNNPNYVPPVLHNHNTDEVVTSSNGNTTGPKYQMTMKTNNTTGVQPPIKSRKQQQQPQPQQQQQQTQQHRHQQHQHQQQTHHHNQLHHQQETVIVDDEEDLYKILSELGNDDNSAKNDSKIIKENLDPYANDNVYDDFQKYLTTILEKLHSDKDIKNLVYLKEFNEVFTTNMSKFDAYTKDRTTLYQSIRLSEKQFRSHLLSNIRAMYIDPIIACLGLLYKQEYTNINEFKSTTSIKCGFSYIAKSAEQDEIKNLKESSIILVYNKKYHLLVIKLNHTSYRPSEIIYPNEFKQKVASVFGLLQMEEYSPESTAIFQNINLDYNAITGGLVYDKLVSVSHTYSEELQKFLKGLDKDVFIADFVNYEKVFKLDEENGVNDDDDDMDVDEEKPENKEEEQPQQQEQEGDVDVKMDVEEDGDHELENDVSQANKNDNESESVGQTEEEEEEEEEEEIQVEEAHVPSDELELALGESLAIENDNESENEINQTTTTFVSNENKEDDNNNDDILTKKESTVEVLDPVFQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ANA8</accession>
    <accession>A0A1D8PK73</accession>
    <accession>B6C800</accession>
    <name>MCA1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Metacaspase-1</fullName>
            <ecNumber evidence="3 6">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCA1</name>
        <name type="ordered locus">CAALFM_C305190CA</name>
        <name type="ORF">CaO19.13416</name>
        <name type="ORF">CaO19.5995</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2007-05" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning and identification of a caspase-like gene from Candida albicans.</title>
            <authorList>
                <person name="Ni J."/>
                <person name="Mi Z."/>
                <person name="Yin J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Antimicrob. Agents Chemother." volume="53" first="2392" last="2401">
            <title>Farnesol-induced apoptosis in Candida albicans.</title>
            <authorList>
                <person name="Shirtliff M.E."/>
                <person name="Krom B.P."/>
                <person name="Meijering R.A."/>
                <person name="Peters B.M."/>
                <person name="Zhu J."/>
                <person name="Scheper M.A."/>
                <person name="Harris M.L."/>
                <person name="Jabra-Rizk M.A."/>
            </authorList>
            <dbReference type="PubMed" id="19364863"/>
            <dbReference type="DOI" id="10.1128/AAC.01551-08"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="183" last="189">
            <title>Candida albicans cells lacking CaMCA1-encoded metacaspase show resistance to oxidative stress-induced death and change in energy metabolism.</title>
            <authorList>
                <person name="Cao Y."/>
                <person name="Huang S."/>
                <person name="Dai B."/>
                <person name="Zhu Z."/>
                <person name="Lu H."/>
                <person name="Dong L."/>
                <person name="Cao Y."/>
                <person name="Wang Y."/>
                <person name="Gao P."/>
                <person name="Chai Y."/>
                <person name="Jiang Y."/>
            </authorList>
            <dbReference type="PubMed" id="19049890"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.11.001"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2014" name="Microb. Cell" volume="1" first="58" last="63">
            <title>Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death.</title>
            <authorList>
                <person name="Chin C."/>
                <person name="Donaghey F."/>
                <person name="Helming K."/>
                <person name="McCarthy M."/>
                <person name="Rogers S."/>
                <person name="Austriaco N."/>
            </authorList>
            <dbReference type="PubMed" id="28357223"/>
            <dbReference type="DOI" id="10.15698/mic2014.01.119"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2014" name="FEBS J." volume="281" first="4841" last="4851">
            <title>Roles of Edc3 in the oxidative stress response and CaMCA1-encoded metacaspase expression in Candida albicans.</title>
            <authorList>
                <person name="Jung J.H."/>
                <person name="Kim J."/>
            </authorList>
            <dbReference type="PubMed" id="25158786"/>
            <dbReference type="DOI" id="10.1111/febs.13022"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2015" name="Mol. Cell. Proteomics" volume="14" first="93" last="108">
            <title>The metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans.</title>
            <authorList>
                <person name="Leger T."/>
                <person name="Garcia C."/>
                <person name="Ounissi M."/>
                <person name="Lelandais G."/>
                <person name="Camadro J.M."/>
            </authorList>
            <dbReference type="PubMed" id="25348831"/>
            <dbReference type="DOI" id="10.1074/mcp.m114.041210"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2016" name="Fungal Genet. Biol." volume="97" first="18" last="23">
            <title>Mutational analysis of metacaspase CaMca1 and decapping activator Edc3 in the pathogenicity of Candida albicans.</title>
            <authorList>
                <person name="Jeong J.H."/>
                <person name="Lee S.E."/>
                <person name="Kim J."/>
            </authorList>
            <dbReference type="PubMed" id="27815149"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2016.10.007"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>ACTIVE SITE</scope>
        <scope>MUTAGENESIS OF CYS-292</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2016" name="J. Proteome Res." volume="15" first="1418" last="1434">
            <title>Apoptosis of Candida albicans during the Interaction with Murine Macrophages: Proteomics and Cell-Death Marker Monitoring.</title>
            <authorList>
                <person name="Cabezon V."/>
                <person name="Vialas V."/>
                <person name="Gil-Bona A."/>
                <person name="Reales-Calderon J.A."/>
                <person name="Martinez-Gomariz M."/>
                <person name="Gutierrez-Blazquez D."/>
                <person name="Monteoliva L."/>
                <person name="Molero G."/>
                <person name="Ramsdale M."/>
                <person name="Gil C."/>
            </authorList>
            <dbReference type="PubMed" id="27048922"/>
            <dbReference type="DOI" id="10.1021/acs.jproteome.5b00913"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2016" name="Microb. Cell" volume="3" first="285" last="292">
            <title>Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1.</title>
            <authorList>
                <person name="Laprade D.J."/>
                <person name="Brown M.S."/>
                <person name="McCarthy M.L."/>
                <person name="Ritch J.J."/>
                <person name="Austriaco N."/>
            </authorList>
            <dbReference type="PubMed" id="27683660"/>
            <dbReference type="DOI" id="10.15698/mic2016.07.512"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="13">
        <citation type="journal article" date="2016" name="Mol. Cell. Proteomics" volume="15" first="2308" last="2323">
            <title>The Metacaspase (Mca1p) Restricts O-glycosylation During Farnesol-induced Apoptosis in Candida albicans.</title>
            <authorList>
                <person name="Leger T."/>
                <person name="Garcia C."/>
                <person name="Camadro J.M."/>
            </authorList>
            <dbReference type="PubMed" id="27125826"/>
            <dbReference type="DOI" id="10.1074/mcp.m116.059378"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 6 7 8 9 10 11">Metacaspase that plays a key role in the apoptotic response triggered by the quorum sensing molecule farnesol (PubMed:19049890, PubMed:25348831). Seems not to be involved in caspofungin-induced cell death (PubMed:28357223). Mediates the sensitiveness to oxidative stress by affecting intracellular ATP concentration, mitochondrial membrane potential, endogenous reactive oxygen species (ROS) generation and trehalose biosynthesis (PubMed:19049890). Contributes significantly to the control of mitochondria biogenesis and degradation (PubMed:25348831). One of the main functions of MCA1 appears to be the degradation of several major heat-shock proteins, thereby contributing to weakening cellular defenses and amplifying the cell death process (PubMed:25348831). Plays also a role in amplifying cell death processes by affecting several critical protein quality control systems through the alteration of the protein glycosylation machinery (PubMed:27125826). Shows K/R substrate specificity in P1 and a D/E specificity in P2 and cleaves many proteins including SSB1 and CDC48 involved in degrading misfolded glycoproteins and in the protein quality control system, as well as BGL2, SRB1 or UGP1, that are involved in the biogenesis of glycans (PubMed:25348831, PubMed:27048922, PubMed:27125826). Regulates the hyphal growth, but this function is independent of the catalytic residue Cys-292 (PubMed:27815149). Mediates a protective mechanism in which filamentous cells are more resistant to amphotericin B- and caspofungin-induced programmed cell death than their blastospore counterparts (PubMed:27683660). Required for the virulence in a murine model of systemic candidiasis (PubMed:27815149).</text>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Expression is induced by farnesol, a quorum-sensing molecule that can trigger apoptosis (PubMed:19364863). Protein expression is positively regulated by the enhancer of mRNA-decapping EDC3 (PubMed:25158786).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 8 10 11">Attenuates both oxidative stress-induced cell death and caspase activation (PubMed:19049890). Does not protect Candida albicans from caspofungin-induced cell death (PubMed:28357223). Shows higher accumulation of trehalose and transcription of the genes related to trehalose biosynthesis (TPS2 and TPS3) under the condition of oxidative stress (PubMed:19049890). Leads also to lower intracellular ATP concentration and mitochondrial membrane potential, and less endogenous reactive oxygen species (ROS) generation (PubMed:19049890). Leads also to a general increase in the O-glycosylation of proteins after farnesol challenge (PubMed:27125826). Reduces virulence in a murine model of systemic candidiasis (PubMed:27815149).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase C14B family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABV00958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_718112.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0053">Apoptosis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <name>Q5ANJ1_CANAL</name>
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            <fullName evidence="13">NuA3 HAT complex component NTO1</fullName>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
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            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
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    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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        <property type="entry name" value="zf-HC5HC2H_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
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            <end position="394"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000179155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2025-06-18" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQ36</accession>
    <accession>A0A1D8PEH9</accession>
    <accession>Q5APJ3</accession>
    <accession>Q8X0Z8</accession>
    <name>SHO1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>High osmolarity signaling protein SHO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SHO1</name>
        <name type="synonym">SSU81</name>
        <name type="ordered locus">CAALFM_C109140CA</name>
        <name type="ORF">CaO19.12235</name>
        <name type="ORF">CaO19.4772</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Mol. Cell. Biol." volume="25" first="10611" last="10627">
            <title>The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Roman E."/>
                <person name="Nombela C."/>
                <person name="Pla J."/>
            </authorList>
            <dbReference type="PubMed" id="16287872"/>
            <dbReference type="DOI" id="10.1128/MCB.25.23.10611-10627.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC 64385 / 1001</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="2226" last="2236">
            <title>Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.</title>
            <authorList>
                <person name="Liu T.T."/>
                <person name="Lee R.E."/>
                <person name="Barker K.S."/>
                <person name="Lee R.E."/>
                <person name="Wei L."/>
                <person name="Homayouni R."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="15917516"/>
            <dbReference type="DOI" id="10.1128/AAC.49.6.2226-2236.2005"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="731" last="741">
            <title>The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan.</title>
            <authorList>
                <person name="Li D."/>
                <person name="Williams D."/>
                <person name="Lowman D."/>
                <person name="Monteiro M.A."/>
                <person name="Tan X."/>
                <person name="Kruppa M."/>
                <person name="Fonzi W."/>
                <person name="Roman E."/>
                <person name="Pla J."/>
                <person name="Calderone R."/>
            </authorList>
            <dbReference type="PubMed" id="19563901"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2009.06.008"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="1235" last="1249">
            <title>Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans.</title>
            <authorList>
                <person name="Roman E."/>
                <person name="Cottier F."/>
                <person name="Ernst J.F."/>
                <person name="Pla J."/>
            </authorList>
            <dbReference type="PubMed" id="19542310"/>
            <dbReference type="DOI" id="10.1128/EC.00081-09"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="FEMS Yeast Res." volume="9" first="942" last="955">
            <title>The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans.</title>
            <authorList>
                <person name="Roman E."/>
                <person name="Alonso-Monge R."/>
                <person name="Gong Q."/>
                <person name="Li D."/>
                <person name="Calderone R."/>
                <person name="Pla J."/>
            </authorList>
            <dbReference type="PubMed" id="19656200"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2009.00545.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2010" name="FEMS Yeast Res." volume="10" first="452" last="461">
            <title>Functional analysis of Candida albicans genes encoding SH3-domain-containing proteins.</title>
            <authorList>
                <person name="Reijnst P."/>
                <person name="Walther A."/>
                <person name="Wendland J."/>
            </authorList>
            <dbReference type="PubMed" id="20402797"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2010.00624.x"/>
        </citation>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2010" name="Mol. Microbiol." volume="76" first="733" last="748">
            <title>A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid medium.</title>
            <authorList>
                <person name="Zucchi P.C."/>
                <person name="Davis T.R."/>
                <person name="Kumamoto C.A."/>
            </authorList>
            <dbReference type="PubMed" id="20384695"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2010.07137.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="715" last="725">
            <title>Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.</title>
            <authorList>
                <person name="Cantero P.D."/>
                <person name="Ernst J.F."/>
            </authorList>
            <dbReference type="PubMed" id="21375589"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07604.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 8 9 10 11">Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Mediates resistance to oxidative stress. Controls the activation of the CEK1 MAP kinase. Influences the molecular weight and polymer distribution of cell wall mannan. Involved in invasive filamentation into semi-solid medium and plays a role in morphological dimorphic transition which is a differentiation program characteristic of C.albicans and which is known to play a major role in pathogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Repressed by caspofungin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ272003">
        <property type="protein sequence ID" value="CAC81238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_718365.2"/>
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    <dbReference type="STRING" id="237561.Q5AQ36"/>
    <dbReference type="EnsemblFungi" id="C1_09140C_A-T">
        <property type="protein sequence ID" value="C1_09140C_A-T-p1"/>
        <property type="gene ID" value="C1_09140C_A"/>
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    <dbReference type="GeneID" id="3634944"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109140CA"/>
    <dbReference type="CGD" id="CAL0000185371">
        <property type="gene designation" value="SSU81"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09140C_A"/>
    <dbReference type="eggNOG" id="ENOG502QW7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043316_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQ36"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="PHI-base" id="PHI:3022"/>
    <dbReference type="PRO" id="PR:Q5AQ36"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="P:cellular response to neutral pH"/>
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    <dbReference type="GO" id="GO:0034599">
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        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
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    </dbReference>
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        <property type="term" value="P:regulation of actin filament polymerization"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
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        <property type="entry name" value="SH3DOMAIN"/>
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    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000410363" description="High osmolarity signaling protein SHO1">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="13"/>
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    </feature>
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        <location>
            <begin position="310"/>
            <end position="319"/>
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    <feature type="sequence conflict" description="In Ref. 1; CAC81238." evidence="12" ref="1">
        <original>G</original>
        <variation>D</variation>
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            <position position="227"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAC81238." evidence="12" ref="1">
        <original>T</original>
        <variation>I</variation>
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            <position position="238"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAC81238." evidence="12" ref="1">
        <original>I</original>
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            <position position="240"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAC81238." evidence="12" ref="1">
        <original>A</original>
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        </location>
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    <evidence type="ECO:0000250" key="1"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15917516"/>
        </source>
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        <source>
            <dbReference type="PubMed" id="16287872"/>
        </source>
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        <source>
            <dbReference type="PubMed" id="19542310"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="19563901"/>
        </source>
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        <source>
            <dbReference type="PubMed" id="19656200"/>
        </source>
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            <dbReference type="PubMed" id="20384695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="21375589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <sequence length="388" mass="41071" checksum="E1CDD8616752F952" modified="2017-05-10" version="2">MGFSLSNFTSDPFAISTVSFGIMAWVVAIAGAASSKQENFPHFSWWGISYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNSTNNLIYNSNSAGNLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSLRGQGHEQLGSGSHNHNANNANNNIPIGAGNAIIGKGEMSPYDDRFAASGVNQPTSESLRLASGPQMGNGPFTTTGAIINPNLQQPLSGSIGGSAHHTPTNINNNNNNNNNTGYMTSSHLTGLENFSSPHVPGSGAGAGLGVGAGRDLTHNSNGGGGGSGGGPASANNSNNTNKRNTIYTDSETGTGITFRYKAKALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCF1</accession>
    <name>A0A1D8PCF1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore protein mis13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KRP1</name>
        <name evidence="3" type="ordered locus">CAALFM_C101070CA</name>
        <name evidence="2" type="ordered locus">orf19.10805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718118.2">
        <property type="nucleotide sequence ID" value="XM_713025.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCF1"/>
    <dbReference type="SMR" id="A0A1D8PCF1"/>
    <dbReference type="STRING" id="237561.A0A1D8PCF1"/>
    <dbReference type="GeneID" id="3640172"/>
    <dbReference type="KEGG" id="cal:CAALFM_C101070CA"/>
    <dbReference type="CGD" id="CAL0000186209">
        <property type="gene designation" value="KRP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_01070C_A"/>
    <dbReference type="eggNOG" id="ENOG502S2VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCF1"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000186209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW25803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="54676" checksum="89A0D210559F99EB" modified="2017-01-18" version="1">MRTSGAGKKKALTRKKSKKQAKLVHDTDDDEQATPQPSLLSRKNQLSDLFSSQENFTKNSAPKKRHTFEEDGEFVYKRSQSPTQQSRKKRKVNTPVTQLHEEIDLMAREDINSDSSDDIFNLSRKKNKQRVKGQSVKNPTKLRSPLGNGYNSDDYIEQVSRETLQLHDNEKTVSNKRRQSYLNRGKRVSSIGNGFVGVPHKEVPVSDYYKLLDTTMPGPDRLRQLLIWNMKKQFEKDEEDLKQRESEDQTAPSIARVIKEEIIRDLTEKKISTSWYDNRNNNIETISGKVVTVPNPLNITNLKNIDIYTKKLKNLRKQKAEWHKVYKQAIRPLETMKISLSDDKKQLNKYIKEERVGNIQPDAIDNSMVETIEANHTEVKSNITKLEPEVDKLYFTAFQLNRASDLLKSVEQQQLNKKVSQYLQGYSNKSKVEAYKSLPSSSGSNNRWSIPSKNVDTKDLLRAICRLETQNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PCV7</accession>
    <name>A0A1D8PCV7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LYS2</name>
        <name evidence="20" type="ordered locus">CAALFM_C102820WA</name>
        <name evidence="19" type="ordered locus">orf19.10487</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW25963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_721469.2">
        <property type="nucleotide sequence ID" value="XM_716376.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PCV7"/>
    <dbReference type="SMR" id="A0A1D8PCV7"/>
    <dbReference type="FunCoup" id="A0A1D8PCV7">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PCV7"/>
    <dbReference type="GeneID" id="3636875"/>
    <dbReference type="KEGG" id="cal:CAALFM_C102820WA"/>
    <dbReference type="CGD" id="CAL0000183678">
        <property type="gene designation" value="LYS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_02820W_A"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PCV7"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17647">
        <property type="entry name" value="A_NRPS_alphaAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000046">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000035">
        <property type="entry name" value="L-2-aminoadipate reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000049">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase large subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000020">
        <property type="entry name" value="Peptide synthetase mbtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="848"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0000183678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AOW25963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1404" mass="155296" checksum="EA641013DDCA0CA7" modified="2017-01-18" version="1">MTDFWLNYLDNPTLSVLPHDFLKPANNKSVEGTYTFNIDNGSTDFKFGLAVFAALVYRLTGDEDIVIATDESANTPEFIVRLNLTPELTFQELVSKITKEYENSISQINYKALSEVSHRIKEAKGLDENPGLFRLSYQHAHSNQQLNTTVEGSIRDLAIYTDGTKFTIYYNALLYSHERIVIFGEQFAQYLTTVSNDTNTVITKVNLITDSQKKNLPDPTIDLDWSGYRGAIQDIFMDNANKHPDRTCVVETESFLDSNSKTRSFTYQQINQASNVVGNYLKETGIKKGDIVMIYAYRGVDLMIAVMGVLKAGATFSVIDPAYPPARQNIYLSVAKPKGLIGLEKAGTLDQLVVDYIGSELDVISTIPQLKVQDDGTLVGGKLEGADNDCLNDYQKFKDQPTGVIVGPDSNPTLSFTSGSEGIPKGVLGRHYSLAYYFPWMAKRFGLSEKDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTADDIGTPGKLADWMAKYGATVTHLTPAMGQLLSAQATTAIPSLHHAFFVGDILTKRDCLRLQSLAENVFIVNMYGTTETQRSVSYFEIKSRKADPTYLKNLKDVMPAGTGMHNVQLLVVNRNDRSQTCGVGEVGEIYVRAAGLAEGYRGLPDLNAAKFITNWYVNPDKWIEQDEANKNSSETWREHGWLKPRDRMYRSGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVRRDKNEEPTLISYIVPKDSPELKTFKADVDDSIEEANDPIVKGLVAYRELIKDIKGYLKKKLASYAIPTIIVPLVKLPLNPNGKVDKPKLPFPDTAQLAAVAKLSVSSHDAQAAEEENLTKLEEQIRDLWLDVLPNRPATISKDDSFFDLGGHSILGTRMIFELRKKLNVEIPLGVIFKNPTVEQFAKEVEKVIKGGQDFQLADEGKTIQEENKDVADSQSENLNYAEDAKELSKSALLESYSSLKQLPSGSINVFVTGATGFLGSFIVRDLLTARNKNLDIKVYAHVRASSKEAGLQRLRQTGITYGIWDENWAEKIEIVLGDLSKEKFGLDNSQWLDLTNNIDVIIHNGAFVHWVYPYSQLRDANVIGTINVLNMAGEGKAKFFSFVSSTSALDTDYFVNLSDELLAQGKNGISEADDLQGSAKGLGNGYGQSKWAAEYIIRRAGERGLKGCITRPGYVTGFSKTGASNTDDFLLRMLKGSAELGLYPDITNNVNMVPVDHVARVVTATALNPPSSEELTVAHVTGHPRIQFNDFLGCLKAYGYEINPVDYPVWTSALEKFVTEESKESALFPLLHFVLDNLPQDTKAPELDDSNAAKSLKQDSKYTGEDFSAGKGVDLDQTGVYISYLIKIGFLPKPTGTGEKKLPEVEISDESLKLISGGAGARGSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDT6</accession>
    <name>A0A1D8PDT6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAALFM_C106530CA</name>
        <name evidence="11" type="ordered locus">orf19.13639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718847.2">
        <property type="nucleotide sequence ID" value="XM_713754.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDT6"/>
    <dbReference type="SMR" id="A0A1D8PDT6"/>
    <dbReference type="FunCoup" id="A0A1D8PDT6">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDT6"/>
    <dbReference type="GeneID" id="3639521"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106530CA"/>
    <dbReference type="CGD" id="CAL0000197778">
        <property type="gene designation" value="orf19.13639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06530C_A"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDT6"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="327"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="706"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="876"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1226"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1278"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000197778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AOW26309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1372" mass="157602" checksum="298ECB376CDE93E0" modified="2017-01-18" version="1">MSDNIEDRSEIPSDAKEIVTTNEIEATDSERTTNVDNELRQDESNEQTGDDSNDNLASKRQLINDLLHNDHFEEGTERYIIPQNFLHEFLNLPIDNFSDLKDQLGPIDFHSLLNEQGNLYPENEEPVTFCHVSPEVFQHLGEWFGILGQPIIRAIIINPDTKEKQIERFPPLFWVHQLGKKTQPTYLRHRHNGSNHNHHHHGHHDSPIPVLLSKTSTFHRLMDVIRYNVLKAPRKSTKDFRIWFIVPQDKGLQYLISIQTFMFDISKKTLVSPNMLEDALKDHGIVASSYNIMVEAKEKHQTEFPIDQFILSHSNAYEEVSQGGGHLGLSNMGNTCYMNSALQCLLHVPEINYYFFYNIYKKELNFDNPLGYHGDVANAFGSLLKQAFDHVKNSSSISPREFKSTIGRYSSMFSGYLQQDSQELLSWLLDALHEDLNRIHQKPYCEKPELKDDEIDDPQAITKLANTCWNQHKARNDSVIIDLFTGLYQSTLICPDCGKKSITFDPFNDLTLPLPISKKWYHTFTIVDLSNQGVIPERIMKLEVELNKTSNFDDLLSYLSNFLNVPSTELFAYEIFQNAIYSDFQLDYTKNKFLPISDIIRDTDDVIVYIVPHNPAVDIIVPVFNAVEDADSSYQMVNFFGIPLFVVMNKEVDVNSFGFIRKKLLETVSLLSKIDLVDEYEKIKRSNEDYVEKVFYKKSDFPALSQPLETSDCEKNNNNTSDNDDDEDADNDEGYDSEVSLANPYLGANFGFKIMYVHDYSPKLNSNLRSRYNHDQTTKFKQTERVINVPTHKPTFSDFKPLSDQLSESKRNYYFYPDYKKMDDEMDQLVEEVNQNLAEQEEARSSGSENSSRASEEQDGFVLINKEDTLKQQSTVPAAAETVPPPLPVRNNTGVHIPSSDEETESEANLGSLFDSTSNLPLPPPSTYSESTKPSNVNSPMESNFESSSADLNSGTTLISKDTVLLCDWDKEIYQKCFGDKELQAWENISNLPNPELEKNRAHFERQRKAKITLSDCLKSFSTPEILGEHDLWYCPRCTEHKRATKTIQLWSTGDILTIHLKRFHSARAFSDKIDVLVDFPIEGLDISSYVANTDLTPEDCLYDLIAVDNHYGGLGGGHYTASVKNFRDDKWYYFNDSRVTEINNPQEVVANSAYLLFYRRRSSKGAGILGGENFIDLLQKGREEYSESLQKKRLVLQNVGQIVNTYAKIEQDIIDKETEKQKEEQEQEQEQEQEQEQEQEQEPDQEPDQDQEPDQEPDQDQDQEPDQEPDQDQEQNETIKKSRPFDELKPSTSETNNQQQTTQFNFDDEDNDYDYEAEVEDSNIRKQRLLSKENNSNKLVHIKSNGRQEVTSSPVPIETDGDTDVTDSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PDY7</accession>
    <name>A0A1D8PDY7_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">NPR1</name>
        <name evidence="13" type="ordered locus">CAALFM_C106780WA</name>
        <name evidence="12" type="ordered locus">orf19.13612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718821.2">
        <property type="nucleotide sequence ID" value="XM_713728.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PDY7"/>
    <dbReference type="SMR" id="A0A1D8PDY7"/>
    <dbReference type="FunCoup" id="A0A1D8PDY7">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PDY7"/>
    <dbReference type="GeneID" id="3639498"/>
    <dbReference type="KEGG" id="cal:CAALFM_C106780WA"/>
    <dbReference type="CGD" id="CAL0000199299">
        <property type="gene designation" value="NPR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_06780W_A"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PDY7"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="NITROGEN PERMEASE REACTIVATOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="457"/>
            <end position="788"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <begin position="9"/>
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        </location>
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        <location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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    </evidence>
    <sequence length="833" mass="90475" checksum="0CA828F32A682686" modified="2017-01-18" version="1">MSTDIENTSQQSQSPQQPQQQQQQQQQQQPQQPMSSLTKLLHESTSTLASPVLSRNTSEVTFKDQGRRTPEILNISDTVDAKSPGITIDVSKPKPSPIDTDGMNVEPQAVHGFDPSPNTKVSFSSPFSPTSPFTRQSSNSFSSNQAFQNTRGAVASPRYIKNNSVSHSSVFMGGESLSSSIPYSAPGGGRGNPASHSGNTGSLQRENSFSSLNTSDSNSSAHIPNLPNGQPINSIHIQSPQVSASSIDSRFVVSKQRIAQAQAQASLSSSQRSNSQSGLSFFFSQKSKPAVKRDSTTDLGAFYNNSYQDRDAPIVSGSPNSLSSAESTVSYGSSAPTRHNSMANLKRFFKKSTPTTSQPVGTSNLSSSLRSASSGASGAMNIPNSLNGQTNNGYQSPSSFSASTSNTSYSQSPGTNSSSVTRSSTLQNKMNYHERRQSVSGIVNNSQQLPFSKRYHSKNAESLGAGAGGSVRLLTRVSDGLTFAVKEFRAKYQNESKRDYAKKITGEYCIGSTLKHPNIIETVEICYENERIHQVMEYCDFDLFAIVMSNKMSREEINCCFKQILAGVHYLHSMGLAHRDLKLDNCVIDKRGIVKIIDFGSAVVFSYPFTKTLIEAQGIVGSDPYLAPEVCVFNKYDPRPVDVWSVAIIYCCMMLKKFPWKVPKLSDSSFKLFASRGEFIPISEMLKKTPNDMEKSNSNGSSGGGLSNLEDISEALEDEITAGAKQKPSTTGQNGATANGKDHTSSETGANRLLLALPEDCRRLIGRMVELAPACRITIDEVLNDSWLKSVNMCTVEESSPGVFEVIKCEDHEHTQVDQSKAHIAAFEKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="313" mass="36061" checksum="A0C01D01DABBC000" modified="2017-01-18" version="1">MTLENLQVKPAEKKLVICLLPGVQSSIHSLDSDRLSLYIIRHGKIYYQFIKSLVAKHKQTIFIIQYNHNTSSTTETTTSNNNIEDVLNYFQFLYQEINSSQQYRFTSFSTIIMYDTAQYDKYQLTPQFIYIQQLLRYISLKHGMKIVSLRNMVDALTIGNIEQLLLTLDSISPIPILDSKGVEIAVQTNDIDRTESNGHEASHNKSQINLYIPYTWDSWNKIVVQGKSIVLPNTDEIIIRNESRLEELDSNYEKSLSRESKNNVNGGTIVDLLLPQDYLQTRNKNKPKIESLPNSTYSLSDMLREIVQPSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PE69</accession>
    <name>A0A1D8PE69_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C108080CA</name>
        <name evidence="12" type="ordered locus">orf19.5079.1</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019475130.1"/>
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    <dbReference type="SMR" id="A0A1D8PE69"/>
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    <dbReference type="GeneID" id="30515029"/>
    <dbReference type="KEGG" id="cal:CAALFM_C108080CA"/>
    <dbReference type="CGD" id="CAL0000199894">
        <property type="gene designation" value="orf19.5079.1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_08080C_A"/>
    <dbReference type="eggNOG" id="KOG3300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PE69"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000199894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW26448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="128" mass="15443" checksum="AA4D97BEC9734561" modified="2017-01-18" version="1">MQDLPPIGGYEPIQWKRNIPSRGFSGTVYFWGILGLMSFGFYKYYKAADEQREFTRERNWARFHLEPLLIAEEDRNVARRYFAELKRRELVKESMSPENREKFEEDIYNDKSKFRFPRYTAGLNPKDV</sequence>
</entry>
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    <accession>A0A1D8PEH4</accession>
    <name>A0A1D8PEH4_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAALFM_C109020WA</name>
        <name evidence="9" type="ordered locus">orf19.12222</name>
    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cal:CAALFM_C109020WA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
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        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000196894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW26537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="247" mass="27824" checksum="47E29E10F2D1B83D" modified="2017-01-18" version="1">MFKQIITSSSTKSTRLFTSSTLKYLSTSSSLLKPTLAAAAAAASITTTTTTTDNSSEYLTTGGSTHSIPAKGFRLSQPKTWEESNESALSKATKFLFLSEIARGMYICLEMYFRAPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERIDGSRRTYKYDIDMTKCIYCGYCQESCPVDAIVETPNVEYSTATREELLYNKEKLLENGDKWEQELQYCIDADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PEI8_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C109300CA</name>
        <name evidence="3" type="ordered locus">orf19.12253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_723475.2">
        <property type="nucleotide sequence ID" value="XM_718382.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEI8"/>
    <dbReference type="SMR" id="A0A1D8PEI8"/>
    <dbReference type="STRING" id="237561.A0A1D8PEI8"/>
    <dbReference type="GeneID" id="3634831"/>
    <dbReference type="KEGG" id="cal:CAALFM_C109300CA"/>
    <dbReference type="CGD" id="CAL0000175342">
        <property type="gene designation" value="orf19.12253"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_09300C_A"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEI8"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000175342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW26564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="297" mass="32637" checksum="261860A6405002C0" modified="2017-01-18" version="1">MTPAPTSTLATTEKPNTKTSSKGYQIDENSFHKLAIGGSLPNQYPKFTDKLQERKFILEHTAATFRIFARNGFNEGVAGHCSVRDPLEPNTFWINPLGLHFALIRAEDLVHVDEDGNILPDGNQDPINAAGFAIHSSLHKARPDVNAACHTHSLYGRAYSAFGKPLEMINQDSCTFFNNQAVYNSFGGVAIEKDEGKAIAEAAGDARAVILQNHGLLTMGKTIDEAAYLFMLMEKTCHAQLLADAAESKDKPKQYIADSEAEYTARITSNPAILYTVFQSDYKLEERLSNGDFKFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PEV8</accession>
    <name>A0A1D8PEV8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GPC1</name>
        <name evidence="16" type="ordered locus">CAALFM_C110460WA</name>
        <name evidence="15" type="ordered locus">orf19.8603</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711206.2">
        <property type="nucleotide sequence ID" value="XM_706114.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PEV8"/>
    <dbReference type="SMR" id="A0A1D8PEV8"/>
    <dbReference type="FunCoup" id="A0A1D8PEV8">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PEV8"/>
    <dbReference type="GeneID" id="3647183"/>
    <dbReference type="KEGG" id="cal:CAALFM_C110460WA"/>
    <dbReference type="CGD" id="CAL0000184780">
        <property type="gene designation" value="GPC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_10460W_A"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PEV8"/>
    <dbReference type="OMA" id="YIDYYGK"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106158">
        <property type="term" value="F:glycero-3-phosphocholine acyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090640">
        <property type="term" value="P:phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="366"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000184780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW26675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="410" mass="47676" checksum="A851E205C2AA5BB9" modified="2017-01-18" version="1">MSSLSRSNSTGSVPYLDMSKLMFANDFDFGLHLNEMKTKTKQKLHTKNLELDKLQEIINQRLQNFDKRVHKQLESSATEKAFYATSVFLIFCAGFIIGKYPIYFPYFHTALFVVLMPIRFYTYFKSSFQYYLADLCYYVNLLLMLFIWVFPESPTLFVSVFSLSLGTLSWAVITWRNSLVLHSIEKTTSSFIHVMPPVTMFVMVHELPEEYIKSRYPGIAAIDNWNFVASIITTSIYYTIWQVSYHYFISIRKKDQIEKGKVTSFSYLKNKNKSTPLGKFVNGLPYLWMQTLAFTLIQFFYQVLTMTPCPIWFKYKHACGAFVVFIFLWASYNGATYYIDVFGKRLEKEVDKLKKEVINLQQENEKIKNSPVQRPVNGSVDDVGALDEDLNSESKEKEQVESTDDKGVTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PF11</accession>
    <name>RL8A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein eL8A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L8-A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPL82</name>
        <name type="ordered locus">orf19.2311</name>
        <name type="ORF">CAALFM_C111030WA</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (By similarity). Mature ribosomes consist of a small (40S) and a large (60S) subunit (By similarity). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (By similarity). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330695.1">
        <property type="nucleotide sequence ID" value="XM_019475150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PF11"/>
    <dbReference type="SMR" id="A0A1D8PF11"/>
    <dbReference type="FunCoup" id="A0A1D8PF11">
        <property type="interactions" value="1248"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PF11"/>
    <dbReference type="EnsemblFungi" id="C1_11030W_A-T">
        <property type="protein sequence ID" value="C1_11030W_A-T-p1"/>
        <property type="gene ID" value="C1_11030W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644419"/>
    <dbReference type="KEGG" id="cal:CAALFM_C111030WA"/>
    <dbReference type="CGD" id="CAL0000174842">
        <property type="gene designation" value="RPL82"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11030W_A"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PF11"/>
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    <dbReference type="OrthoDB" id="29563at2759"/>
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            <begin position="1"/>
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        </location>
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        <source>
            <dbReference type="UniProtKB" id="Q5ANA1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW26729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="260" mass="28258" checksum="045B60628E71135E" modified="2017-01-18" version="1">MPSSKKVAPAPLATKSKASTSTKNPLFESTPKNFGIGQSIQPKRNLSRFVKWPEYVRLQRQKKILSLRLKVPPSIAQFSQTLDKNTAAQAFKLLNKYRPETSAEKKERLTKEAAAIAEGKTAKDVSPKPVVVKYGLNHVVSLIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIVKGKARLGTLVHKKTSAVAALTEVNSADEAELSKLVSTINANYIEKYEENRKHWGGGIMGSKANDKIAKKAKAAAAAVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PF18_CANAL</name>
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        <recommendedName>
            <fullName evidence="6">Peroxin/Ferlin domain-containing protein</fullName>
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    <gene>
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        <name evidence="7" type="ordered locus">orf19.9849</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017623">
        <property type="protein sequence ID" value="AOW26727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_708825.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PF18"/>
    <dbReference type="STRING" id="237561.A0A1D8PF18"/>
    <dbReference type="GeneID" id="3644421"/>
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    <dbReference type="CGD" id="CAL0000188880">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C1_11010C_A"/>
    <dbReference type="eggNOG" id="ENOG502S05F">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="6">
        <location>
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            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000188880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW26727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="396" mass="46594" checksum="51FF29D7C70FB4C4" modified="2017-01-18" version="1">MPEFKSHIRATFEPTDTKLLTNTPTSRLLTESPKLSTALSQIFPYLLLIDNLLEILTWTNEDHYQNFLLLTCYSCIIVYWNWVSHVILPILMTLAFSSIVWFISSIIYDSKYDEKPTIEEVLYTLHNITIRCEMLLRPIKHVPIQRKHFIKLVIASIFLTPLNFAVSKTLIPPQKYILFLGLFLFTFHSPYSFAIRRLLWRSLYVRIAILYITGLDIKIRKDYDPNDYQTVSRVASASNSDAEGLGGIPVLSDFKIIKKRVVSPTQLKQTVVFEILENERRWLGVGWSSLLYPSERPNFCYEGSYNLAPNITVHKENFPFPVFENDLYAYSWEWIDDDWSLELEYQKSKAHDGWVYFDSNWGNGRVRDGFSRYTRSRKWTRRATLIIDKRETVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PG40</accession>
    <name>A0A1D8PG40_CANAL</name>
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        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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        <name evidence="9" type="ordered locus">CAALFM_C200430CA</name>
        <name evidence="8" type="ordered locus">orf19.9635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719534.2">
        <property type="nucleotide sequence ID" value="XM_714441.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PG40"/>
    <dbReference type="SMR" id="A0A1D8PG40"/>
    <dbReference type="FunCoup" id="A0A1D8PG40">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PG40"/>
    <dbReference type="GeneID" id="3638818"/>
    <dbReference type="KEGG" id="cal:CAALFM_C200430CA"/>
    <dbReference type="CGD" id="CAL0000184121">
        <property type="gene designation" value="DPB4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_00430C_A"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="A0A1D8PG40"/>
    <dbReference type="OMA" id="NTYRRKV"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0000318"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0000198195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AOW27419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114746" checksum="F44C900375931CA9" modified="2017-01-18" version="1">MQQDDDSLTNRSSPPMASKDSRLQPPTRTIIRQQKLKYTFIGYIIVLIFLAITQFIGVGFFKEGFLLSRTVLPNISNCSQQIDCMTPRFEKAILLVIDALRFDFVIPIPGSNEYYHNNFPILYDLASSSQNNAILLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFNGDAIDEDNWLLQLHKINKTIAFMGDDTWKALFNEYIHPDFNFPYDSLNVWDLDTVDNGVIEHLFPLISKENCTKWDLLVGHFLGVDHVGHRFGPQHYSMKDKLNQMNQVISKVIENIDDKTVLIVMGDHGMDSTGNHGGDAPDELESTLFMYAKNKKFLKKDQSFYNISGLGENYRSVNQIDLVPTISLLLGLPIPYNNLGFPIDEAFGNVDELSVASQKTINQIKAFRDDTPNLSGSLIEQYQSYATNYSRFGGKSKKHYWQLIEQAKQYQSLSLEQCKTLWARFDLRFIGIGIGILFLALTFMITYARSIPAVRVSTMSFEFIGSVVAMTIMGLVLSFSIYIVLKPGDFTLKICLAIGAALGMVIGFWAPIMDRFSVGFIWHQTVDFFLYNFNSWSLMGILFVSFHCLIFASNSYVVWEDKMVSYFLITFGACCVYACFINNKLPERAKILAISHAITFTICTRIVSMVNLCREEQRPYCEPNFTNSWWSVLLLHFAAYLLPACIKSFYMLSDSYHSAAPLWIGTGVKFLLFMNAVYWTFEYVSNSEYFNKLNLIIGLSLIKSLKLAIARLVLFISLILANFSWSRGPLCVKLELSEASNTIDIEESDDMSPGINNNNNNSNNKTATILGYGNVYGSSYFLLVLNFTVAIMLTTKPLGSLSISLLIVQILSLLEILDVLSIRRNLITPIIFGLLGYQHFFSTGHQATIPSIQWELGFMTTETIVFPFTHLNIFLNTFGPFFIPALAIPLITIWKIVPSSKPITLLSQIITNITTLITYHLFTGLSSLIFAAHFRRHLMVWKIFAPRFMLSGLLIISLNLFLIFVALWFGTSKILTQINRIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PH25</accession>
    <name>A0A1D8PH25_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAALFM_C204100WA</name>
        <name evidence="10" type="ordered locus">orf19.8431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720935.2">
        <property type="nucleotide sequence ID" value="XM_715842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PH25"/>
    <dbReference type="SMR" id="A0A1D8PH25"/>
    <dbReference type="STRING" id="237561.A0A1D8PH25"/>
    <dbReference type="GeneID" id="3637379"/>
    <dbReference type="KEGG" id="cal:CAALFM_C204100WA"/>
    <dbReference type="CGD" id="CAL0000182979">
        <property type="gene designation" value="orf19.8431"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_04100W_A"/>
    <dbReference type="eggNOG" id="ENOG502S831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PH25"/>
    <dbReference type="OrthoDB" id="5424147at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000182979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW27436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="378" mass="43755" checksum="66C160397796E7C4" modified="2017-01-18" version="1" fragment="single">VVNFSYQKNKNLELKIYQQTKYILITSINTHPCSYPKLPTDFMIRSCLVRIGNIPSVTPSLHSTPFYTKKLLHPLLIHSSFIRKFSSCRPEFQAVPSLNNDKPLKNTQSSQKNGNNEKDTNSKEEQKVEDNATNTDTLSSGKVLPEGVSKDEFLTEIFGNLDPYIDTYSIYKQLREAEFTPEQSDQIISLLVHQLNSKLTKLSTIYAQNFELENEQYLFESAQQEIRVDITRSRDQHINELIALINILERDFNVINDELNNDYLKLKNDSQVAINEGKSENTLNSKKLFLRIQEANHKITTELNSDIKSEIESLRWYLSRWGLITLLVSLFSGLIIFYNTKRRNVTKEAKKDFAPLVIREPSEYEDDDYHTELDRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHP6</accession>
    <name>A0A1D8PHP6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SKY2</name>
        <name evidence="12" type="ordered locus">CAALFM_C206600WA</name>
        <name evidence="11" type="ordered locus">orf19.7708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711842.2">
        <property type="nucleotide sequence ID" value="XM_706750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHP6"/>
    <dbReference type="STRING" id="237561.A0A1D8PHP6"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PHP6"/>
    <dbReference type="GeneID" id="3646563"/>
    <dbReference type="KEGG" id="cal:CAALFM_C206600WA"/>
    <dbReference type="CGD" id="CAL0000196384">
        <property type="gene designation" value="SKY2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_06600W_A"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PHP6"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140206">
        <property type="term" value="P:dipeptide import across plasma membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="220"/>
            <end position="941"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="200"/>
        </location>
    </feature>
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            <begin position="418"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="9"/>
            <end position="34"/>
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            <begin position="36"/>
            <end position="52"/>
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            <begin position="76"/>
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        </location>
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            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
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            <end position="197"/>
        </location>
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        <location>
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            <end position="491"/>
        </location>
    </feature>
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            <end position="507"/>
        </location>
    </feature>
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        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0000196384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW27661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="976" mass="111184" checksum="8A2A1E772ED3883B" modified="2017-01-18" version="1">MTIESRYQAAAAATTPSTPPQLQEQLQLQEQPPLTKISSQSKASTPSVSTSALKKASSLFKLNTNSQSRNKKHTNKQQQQSQPSPTSPKTLTNITSRQSTPTPTPTPSNSTSRPNLRSLLRIGSFSNNQPHIHSNNPHVKNPSITALEGEIEVKIDEEDIEEEDNIEEEDDEIAYLSDSESDLNYDPKAEESHEDYRTGGYHPVSKGEIYYSKKLPNREYIILRKLGWGHFSTVWLAKSRYNGNLSLEKEEEDDEEEEVEESLLDSVDINEYYVAIKFVKSNKNYMEAARDEIKIMNVLNDPINNNHHIPKENISYFKNDNKLHPGYNHVMQLKDDFEISGPNGIHICMVFEILGENVLNLIYRYKRLYRSINSEIKRKESAEENICLQQQSQMKFSKWDTKNWKKSTKSMLSLGLHNKKDTHKHDSTSNNNNNDTNNNFTINHNNNTNTNGQASINTTAISTASSSSLNSNPHEDSFIESSGSGSNSVSGSGSGSGQDNESTTTVDSWEDDLDKKIKSLNSQSLIKLIETSKTVGGIPLYIVKQIVKQMLLAIDYMHHCGIIHTDLKPENILIDIKDINKLIRTIEDEKLSKFRANNNNNLSRSRKASLLSNCSRTRRRRSSSKQLNQHYQSQQQQQQQKSNCCSSSCHIRTLSTTSNSSQSSYFYKKSKNSIVGKYESPIRCSKPLSSSISSDSIFKDVNFNGNDSNNHSNSKPRKKSISKAISPRNFSFFDYNKKDQEMIDDNIEEEEQQQRECEGNIRGGISIKIADLGNATFVDEHFTNQIQTRQYRSPEIILKYKHWGSSTDLWSIGCIIFELITGDFLFDPHDGKCFDKDEDHLAQIVELLGDFPNDEYLLDCKLTGKFFKLNPNPDLKGNSQIMFKNIDQLKIWKLKDVLIEKYKFNKNDYEVDLICDLILKCLKYDLNERYDANSLLKHPWFDSDNNSTISPGLEDRLKSLPNCHDDLPGYTCECKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PHY3</accession>
    <name>A0A1D8PHY3_CANAL</name>
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        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C207690WA</name>
        <name evidence="3" type="ordered locus">orf19.9758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716053.2">
        <property type="nucleotide sequence ID" value="XM_710960.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PHY3"/>
    <dbReference type="SMR" id="A0A1D8PHY3"/>
    <dbReference type="STRING" id="237561.A0A1D8PHY3"/>
    <dbReference type="GeneID" id="3642338"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207690WA"/>
    <dbReference type="CGD" id="CAL0000194164">
        <property type="gene designation" value="orf19.9758"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07690W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PHY3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
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            <begin position="147"/>
            <end position="175"/>
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            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000194164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW27767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="454" mass="51270" checksum="601D647FF48F2810" modified="2017-01-18" version="1">MSTSQANIRSVIHEYEILYTTRIQQKSKNWNDGKLTFYEFNKKIEIHNDDGMLLATDFYRSRSISSVLNSVLVDNSEFRLPNANYFIQIQDKIRVFEREVNLRAKTSDSQKVEKLATKTESVPKRDTIISKSPSSGHPSMSHRKVTSRNLVTTDTKNQNSSINGNSTKSIYSSMGATRMKKTHSPKNNTIHNIAKPSSSGSNINKGLTASKPLRYQGSNVTKTTQNVSGTTTGAKISQYKVHSNDLLTIDSKVSKRLPLRIPPRTSTCFQYIYTPRNDIEKFDVAANDISIYKPLIISGNEPSGEEPIQEKENGQEYVGSKGYDENQKKNENMHNSHDKEMKVNSRPSQPKIVDEYTNTDSVTFSNNEISRISVKKEQPLIVSNTTVDDTDIVYDLSDYEENEKFNAMIKKIKQTQNLQDNSSTSVVNKKPNIVKTGLEAVEFCLSTDSEMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI03</accession>
    <name>A0A1D8PI03_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C207920WA</name>
        <name evidence="8" type="ordered locus">orf19.9737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716031.2">
        <property type="nucleotide sequence ID" value="XM_710938.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PI03"/>
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        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI03"/>
    <dbReference type="GeneID" id="3642294"/>
    <dbReference type="KEGG" id="cal:CAALFM_C207920WA"/>
    <dbReference type="CGD" id="CAL0000182585">
        <property type="gene designation" value="orf19.9737"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_07920W_A"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI03"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000182585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AOW27788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="345" mass="38811" checksum="0875A0BD1FFE1FA1" modified="2017-01-18" version="1">METLPHSKRIEIVKTTLPPCCLRIHPQDTSKIFIGTYKLEDDGSRHGSLDYYSFLDNKLSLISSTATLGAILDIKFNPSDPQMLVSAHSNGHLLIWKFDNNTLELSHDANVHEDTLITSIFFNPNKDSNGSVILLTFTDGYSGLFDLEKLEIDYFDTCHELECWTGSFGEIGQLSNVVYTGGDDSQLIAHDLRTKQQIWTLRRGHDAGIVSILSPNDNWNKTSPNTLWTGSYDDNLRVWDLRVIDKSNPSLISGYIPKIISQENLGGGVWRLIPSPVDNRLLSCCMYDGARIIDANSDSFTVTRYFKQDHQSMCYGGDWSSDGKFIATCSFYDNVVQVWSPDQCV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI15</accession>
    <name>RS10A_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S10A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS10</name>
        <name type="ordered locus">orf19.2179.2</name>
        <name type="ORF">CAALFM_C208040CA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the small ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330801.1">
        <property type="nucleotide sequence ID" value="XM_019475256.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PZY">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.32 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="7Q08">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0F">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0P">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="7Q0R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="8C3A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CX/M=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="8OGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="8OH6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.35 A"/>
        <property type="chains" value="CX/M=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="8OI5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="CX/M=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="8OJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CX/M=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="9G1Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="9G30">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="9G6J">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="L=1-118"/>
    </dbReference>
    <dbReference type="PDBsum" id="7PZY"/>
    <dbReference type="PDBsum" id="7Q08"/>
    <dbReference type="PDBsum" id="7Q0F"/>
    <dbReference type="PDBsum" id="7Q0P"/>
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    <dbReference type="PDBsum" id="8C3A"/>
    <dbReference type="PDBsum" id="8OGJ"/>
    <dbReference type="PDBsum" id="8OH6"/>
    <dbReference type="PDBsum" id="8OI5"/>
    <dbReference type="PDBsum" id="8OJ3"/>
    <dbReference type="PDBsum" id="9G1Z"/>
    <dbReference type="PDBsum" id="9G30"/>
    <dbReference type="PDBsum" id="9G6J"/>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI15"/>
    <dbReference type="EMDB" id="EMD-13737"/>
    <dbReference type="EMDB" id="EMD-13741"/>
    <dbReference type="EMDB" id="EMD-13744"/>
    <dbReference type="EMDB" id="EMD-13749"/>
    <dbReference type="EMDB" id="EMD-13750"/>
    <dbReference type="EMDB" id="EMD-50957"/>
    <dbReference type="EMDB" id="EMD-51103"/>
    <dbReference type="SMR" id="A0A1D8PI15"/>
    <dbReference type="FunCoup" id="A0A1D8PI15">
        <property type="interactions" value="1018"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI15"/>
    <dbReference type="EnsemblFungi" id="C2_08040C_A-T">
        <property type="protein sequence ID" value="C2_08040C_A-T-p1"/>
        <property type="gene ID" value="C2_08040C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="30515149"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208040CA"/>
    <dbReference type="CGD" id="CAL0000177647">
        <property type="gene designation" value="RPS10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08040C_A"/>
    <dbReference type="eggNOG" id="KOG3344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI15"/>
    <dbReference type="OMA" id="ERTKIHR"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456548" description="Small ribosomal subunit protein eS10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7PZY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="118" mass="13813" checksum="3ABD09FE428B4857" modified="2017-01-18" version="1">MLIPKEDRKKIHQYLFQEGVVVAKKDFNQPKHDEIDTRNLFVIKALQSLTSKGYVKTQFSWQYYYYTLTDEGVEFLRTELNIPEGILPLTRLKNAPAERPRPSRGGPRRGGYRGRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI62</accession>
    <name>A0A1D8PI62_CANAL</name>
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        <submittedName>
            <fullName evidence="6">DNA-dependent ATPase</fullName>
        </submittedName>
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        <name evidence="5 6" type="primary">RAD57</name>
        <name evidence="6" type="ordered locus">CAALFM_C208110WA</name>
        <name evidence="5" type="ordered locus">orf19.9720</name>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AOW27805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716015.2">
        <property type="nucleotide sequence ID" value="XM_710922.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI62"/>
    <dbReference type="SMR" id="A0A1D8PI62"/>
    <dbReference type="FunCoup" id="A0A1D8PI62">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI62"/>
    <dbReference type="GeneID" id="3642333"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208110WA"/>
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        <property type="gene designation" value="RAD57"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08110W_A"/>
    <dbReference type="eggNOG" id="KOG1564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="ISHHMRV"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rad51"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="81"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000194828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW27805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="511" mass="58794" checksum="6BC691B51CF40BF5" modified="2017-01-18" version="1">MDDYKQLGPGIFSCSRKFPFLTTRLQQYGKSINDLLQYDEASDHAQLARLVDRPMKEINDYYRNLKKDLQVDPTSVNSLLDSEFISTGLPSIDRELGGGIPIGEVTEIFGASGCGKSHFLFQLLSNCGKEFPTSKNIYISTESFLETKRLKDFIGRNSSNIDTDLDRISYIYCQDLESQDHILFTQLPLKLDSDKGKTKLLVLDSIAQHFRREDSIMNSTYLKEKLEVQEGEIADDRSFQEVKRKQMNQLRRFNKSQKYASRTAKLYYICQLYQHLSRLAQDFNIAIVIVNQVSDYSFESSGSFTEAEAGELDYPLNLDFQTAVSSGWDSRTIYNSIPTANITLKNEEIENLEMELAKSLEERSPNKRQKLSNTSSPQKQEHNLNPRERLERQKSLISKSHEMRNRGSKKIVPTLGYPWATRIKNRIMLSKVYKPILKSNMDGDIVNDDQSLQTNSIHDKRSSAELYKSFVSIDGWQVERFAKVVTSTHGYNPNRFKRYRFIINSQGLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI63</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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        <name evidence="6" type="ordered locus">orf19.11104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000200846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW27846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="410" mass="44636" checksum="F3FF2E4D9CCC210F" modified="2017-01-18" version="1">MVDPFFTFHSRDDYNVQFYYAIINSHRYTTDIKHGGSIISIAAKLLYDKHTPIYQVHLHKIPNSNSTEIIRKRWLFAKNKQIKSSSSSKILSKKDLVDDFIIDIAGSRGIMIDKVILSVVDVDQMTSSIDTGSSNSLTRTGFTNPSVISTKTSNSQSITTTTTKGSSATTTTATATGATETITTTKIITITSCSNDICHLTTVPASLTTVTTTGTVYTTYLPINSVETVVSTKIITITSCSNNNNNNHVCHPTTVLATPSTMTKTIDNTITEYITYCPLTQQPEQLSTINPYTGASATSVTATITSCWEETCQTYITTTAAAAAVIITQTEITTVETVTHDTTTYYVTYTITSQTSNQVHTTKINNEGGNTNELSSSLPAITTTVEGRGISNKIENLLSMLIMVMVMWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PI86</accession>
    <name>A0A1D8PI86_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C208180CA</name>
        <name evidence="7" type="ordered locus">orf19.9713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019330805.1">
        <property type="nucleotide sequence ID" value="XM_019475260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PI86"/>
    <dbReference type="SMR" id="A0A1D8PI86"/>
    <dbReference type="FunCoup" id="A0A1D8PI86">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PI86"/>
    <dbReference type="GeneID" id="3642317"/>
    <dbReference type="KEGG" id="cal:CAALFM_C208180CA"/>
    <dbReference type="CGD" id="CAL0000200640">
        <property type="gene designation" value="orf19.9713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_08180C_A"/>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PI86"/>
    <dbReference type="OMA" id="QKKRTDN"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="234"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000200640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="456" mass="52283" checksum="BEE784F23BB50FBA" modified="2017-01-18" version="1">MSNSLEERLKTHSSAFDGLLSLIPAKYYYDDATQDQWQQKKKSKQEIKQNKRAKLNPESVNNANEYSNGQASAKDVMDNKAKKATSVSLPKKLPKPITQESDEEEEESGDDDDSDEDVEIPDMDVSDDEDDEKQAKEDDDSDIINSNNQLIFDDDGNEVELSSYKKQEIQSTNNNSSDSNNKSKKKQLSDEEQRKRQENLAKLREKLESKINNLKEKRKAIGSKSNGALKSREQILAERQRREELKKQQKRKHDELDNDDEEDSDSGSDSGSDSDSDIDDDKNVLFGNIVFNDGSQVTSDLSKIRNSAEKKKQKGPANKDIKAHLQKLEKKKQKLASMSAEDQEKQREKDKWQRVMAQAEGIKIKDDEKLLKRALKRKEKKKLKSEIEWKERKQVVKDTVAARAKRREENLKARRDNKGKKHQPKLKKFTGTVNKAQLKKKRAGFEGSAKVKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PII5</accession>
    <name>A0A1D8PII5_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C209620WA</name>
        <name evidence="7" type="ordered locus">orf19.8970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017624">
        <property type="protein sequence ID" value="AOW27940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714564.2">
        <property type="nucleotide sequence ID" value="XM_709471.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PII5"/>
    <dbReference type="SMR" id="A0A1D8PII5"/>
    <dbReference type="FunCoup" id="A0A1D8PII5">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PII5"/>
    <dbReference type="GeneID" id="3643797"/>
    <dbReference type="KEGG" id="cal:CAALFM_C209620WA"/>
    <dbReference type="CGD" id="CAL0000180758">
        <property type="gene designation" value="orf19.8970"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C2_09620W_A"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PII5"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009111184" evidence="5">
        <location>
            <begin position="22"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000180758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW27940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="737" mass="84998" checksum="3377BF5F67135079" modified="2017-01-18" version="1">MKLSILSLLGFLTTAAVGVVGSEINPLEPQIIADQVTNGEHKRQSDDESNSQLKSQSKMDVPPTLSMKEFDKLTREKLVLVEFFSPYCHHCKEFAPTWKETYIKFVTEYPDLNIEMKQVNCIESGDLCEREHIDFYPNILLYAPAVDKDGKKTGKSKNIDSFPRNLDRNVENIIKYLREATAEFDSGAINLPSSSQLLDVDTMSKIIDGNISTPMFVSFFPATKRQWKSVEHRGRLGFSNCEDCLPAKQIWDRLSNKILSISDTGHFMCRDHREVCDKLKITSNNEPQFIMFLPESIGAVRFDYNDYVDVNRMKWWVQKLFQNSQFEVVSARGITEVMEYTKVLSHEPIAQFYPLKSKITVVFYYDIDKVTEEDEKILPHLLKTIQESPFNIQLHKGKHKKIEENVLTMGQNLIEYINYDENDKYEFDKSIQVLTTLTTKPTILVFKDNSLIADVYQSLSPEDMKTYDKVESFINSIQYPLYGQLTPQLAPYYFKNNEKYQDHKVVVLFTDLSDLKGTDNQLYKLSLAAHEYHHLKQKYYFDRFKQSNQVSAATVEKLQEQNQETIDALKELQQVIPELWENDQVLFTFIDLPNAYKQFGGVKGWRLNPNNYQVGDVVVLSKDNRYYWNKDTQGNKLTNEPKELKKVLMSLLAKDDKLKAAIVGSPYGGVLGFMDYVHDYGVWGYIGFFLSIYTTGFLVLRLGRRSSRRWLFKRPSSSTPSSGGGGIIGNNFTPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PIW0</accession>
    <name>A0A1D8PIW0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SUMO protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ULP3</name>
        <name evidence="8" type="ordered locus">CAALFM_C300280CA</name>
        <name evidence="7" type="ordered locus">orf19.12896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cal:CAALFM_C300280CA"/>
    <dbReference type="CGD" id="CAL0000178946">
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    <dbReference type="VEuPathDB" id="FungiDB:C3_00280C_A"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="380"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
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        <location>
            <begin position="802"/>
            <end position="854"/>
        </location>
    </feature>
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            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000178946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW28078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="874" mass="101323" checksum="8A1A5072122D8A3E" modified="2017-01-18" version="1">MTFVNNIFFLVPSQRSTEFKTHIAYTKKKNLKCSHNPTIVYKQEPFFCKTSVYMSSLKDKEYPSLKRKGLSIGSGSYKPVNTLGAAPRNELPNSNNVSEETFLSNITMKESYAPGNDPSFSLERAKERRHRLNGLSQSLKTNHSPVDVTEFQITDCFGSSVNVSAKDLRDEPAVSINLKSFHKVGGAYYRSMSRRQHLLNISKNGDYICIFESDYPKSNFLINIDTQLKSLSFAPEALVMELNEGHETIIASHYGRDNEVREYFQNNPTTKVDPSKTLSGTALHRLEKTVQLDNDNDNDLDATERSVSRTRPIRVRTRQASKAFWSSVAEENKEDPLDIVKITDDSPIESVFVEDDYIPYEKPAPFEPDLQYTFPDNKIFRITAKDFATLYNNDWINDAVMDFCIRYDIEEAINQGVVNREDVYAFNSFFYTKLTSGKTEDYYNKVKRWVHKIDLMSFSHIIMPINEKHHWYCCIIRGLPTLLEMIKSQKEKSNNADSPDSEEMFKRWGVEIFVFDSLGLRRDNVKKPLKAFLIDYCKDKYNYDVNTDQIRVTAAKVPRQNNYNDCGLHVIYNVKKWLLNIEACESFWRKWQRGAARTIFLADERNKMRRYWIETLLKLHSEQAPAIKRSSHANEEEDDDDIVEIVDTKTIVPPPTDQPNLSPPSNQKSNAVFDNSFLNQEFGNEHIPRFVVETLNKIFPKRSLHIPDEMKKLVSAFIKDSQSNVSSEQELKEVFIRNHEVIKKEIENQNRPKNKTIRITDAVSNLRIDPGTFFCPTHKEISSGLRKDQLLEEIDARPIIKAIRTPQESDQNSNEKDAEDHATSDSEHVQVEEVNLEEDRNSRQRFTRSRQRAKQNIMDLAIFDNIDRKRRKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ15</accession>
    <name>A0A1D8PJ15_CANAL</name>
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        <recommendedName>
            <fullName evidence="10">NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6</fullName>
        </recommendedName>
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    </gene>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718518.2">
        <property type="nucleotide sequence ID" value="XM_713425.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PJ15"/>
    <dbReference type="STRING" id="237561.A0A1D8PJ15"/>
    <dbReference type="GeneID" id="3639853"/>
    <dbReference type="KEGG" id="cal:CAALFM_C300960WA"/>
    <dbReference type="CGD" id="CAL0000187080">
        <property type="gene designation" value="NDU1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_00960W_A"/>
    <dbReference type="eggNOG" id="KOG4411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PJ15"/>
    <dbReference type="OMA" id="MINAREQ"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000068">
        <property type="entry name" value="Conserved hypthetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000187080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW28144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43551" checksum="ACE2BE9266EF9503" modified="2017-01-18" version="1">MITRSRHISKRLYSTNYSAILFNAQENVNQLLESQDRSSYILAQYIPEPVRNTYLAIRAFNLEINKINEGGSNVQSRAARASSQMSNTLGVSTADLKFKFWSDLILRVFTEDSRNETDLGEPIAILLRDGLKHDFNLNISYFQQFLQTRRHFIKNNSSFQTVNDICSYGEGTFSQLNYLTQGLLLSPSISPSVIRLLEYSTELQSQMSDIAAHIGQATAVSSMILGVPFYAQSRNQITLPVDLMTSSGLSQESLLRLFQGHIKDSAEENQIKEALKNVVYETAITANDHMLTAKSKLEMARQEIKKIVQEQPQDQLLNKFSKKWRKGIPDSLYVPTMAGIPTSLFLNKLEKCNFDLFHGRLQKEWRLPMKSFYYYYMRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PJ59</accession>
    <name>A0A1D8PJ59_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">CAALFM_C300950CA</name>
        <name evidence="8" type="ordered locus">orf19.10035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
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            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
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            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
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        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
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    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="10" type="ordered locus">CAALFM_C306400CA</name>
        <name evidence="9" type="ordered locus">orf19.7425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="CP017625">
        <property type="protein sequence ID" value="AOW28647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716089.2">
        <property type="nucleotide sequence ID" value="XM_710996.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PKH5"/>
    <dbReference type="SMR" id="A0A1D8PKH5"/>
    <dbReference type="FunCoup" id="A0A1D8PKH5">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PKH5"/>
    <dbReference type="GeneID" id="3642260"/>
    <dbReference type="KEGG" id="cal:CAALFM_C306400CA"/>
    <dbReference type="CGD" id="CAL0000183494">
        <property type="gene designation" value="orf19.7425"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C3_06400C_A"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PKH5"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="8">
        <location>
            <begin position="155"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0000183494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AOW28647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="355" mass="40645" checksum="1C2169D8054F80EC" modified="2017-01-18" version="1">MSKRVFITDFFRNKSDSNKKIKVVNKVKNENLVSKAQTVVESGKEVSDPVEYDQRNEKVQETTISSTPSDRLLESGGYADFCKEHHFDKVAWIKSLTVEQREILQLEINHLHITWLAFLHKELTKPYFIALKKFLKSQSNKTIFPPSDKIYSWSHLTPLPNVKCLILGQDPYHNYNQAHGLAFSVLEPTRPPPSLVNIYKTLAIDYPQFQIPDYNKLSKEGKPGGGNLTKWAERGVLMLNAVLTVEAHKANSHANQGWELFTEQVIKVAIDYHSKNNKGFVIMAWGSPAQKRVAKYSKQLSDSNHFLVLRTVHPSPLSAHRGFFDSKVFFKCNEWLAKHKKDKIDWGIIDGNIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PL76</accession>
    <name>A0A1D8PL76_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elongator subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAALFM_C400940WA</name>
        <name evidence="3" type="ordered locus">orf19.12171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW28883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_722766.2">
        <property type="nucleotide sequence ID" value="XM_717673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PL76"/>
    <dbReference type="SMR" id="A0A1D8PL76"/>
    <dbReference type="FunCoup" id="A0A1D8PL76">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PL76"/>
    <dbReference type="PeptideAtlas" id="A0A1D8PL76"/>
    <dbReference type="GeneID" id="3635677"/>
    <dbReference type="KEGG" id="cal:CAALFM_C400940WA"/>
    <dbReference type="CGD" id="CAL0000182587">
        <property type="gene designation" value="orf19.12171"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_00940W_A"/>
    <dbReference type="eggNOG" id="ENOG502S4WT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PL76"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005182">
        <property type="entry name" value="Elongator subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000182587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW28883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="307" mass="35581" checksum="CE4CF10B5D85C761" modified="2017-01-18" version="1">MSLNNPSQDLIFFKDNSLISDKIINQETTTTTTTTASNNFHSYLSVITYNQSTSPNWLINGLIEDTLFGNATKSLNNHESYHQMKKKDIIIKNKKIMIISFLHNKEFYIKNCKRIGINLEEKEKEQQQQFQFIDYFNDLFINLIKNPNDSVKDINKMFDNIINSLNNDSKDDVDVIIIEGVEILLFATNITSNQLIFNINRLNKKCRQLFVVSSKECLFKNNESIGVTFSFDDPMIKINDFLIKLLHRSQLNITLEPLITGRAKDITGSLTISKGCIPYDENLSISINEKEYVYHITKDSQVKLYYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-10-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLC9</accession>
    <name>RL20B_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein eL20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L20-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RPL20B</name>
        <name type="synonym">RPL20</name>
        <name type="ordered locus">orf19.4632</name>
        <name type="ORF">CAALFM_C401520CA</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabn1062" last="eabn1062">
            <title>E-site drug specificity of the human pathogen Candida albicans ribosome.</title>
            <authorList>
                <person name="Zgadzay Y."/>
                <person name="Kolosova O."/>
                <person name="Stetsenko A."/>
                <person name="Wu C."/>
                <person name="Bruchlen D."/>
                <person name="Usachev K."/>
                <person name="Validov S."/>
                <person name="Jenner L."/>
                <person name="Rogachev A."/>
                <person name="Yusupova G."/>
                <person name="Sachs M.S."/>
                <person name="Guskov A."/>
                <person name="Yusupov M."/>
            </authorList>
            <dbReference type="PubMed" id="35613268"/>
            <dbReference type="DOI" id="10.1126/sciadv.abn1062"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit (PubMed:35613268). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:35613268). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (PubMed:35613268).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW28933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblFungi" id="C4_01520C_A-T">
        <property type="protein sequence ID" value="C4_01520C_A-T-p1"/>
        <property type="gene ID" value="C4_01520C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3635615"/>
    <dbReference type="KEGG" id="cal:CAALFM_C401520CA"/>
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        <property type="gene designation" value="RPL20B"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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        <property type="term" value="P:cytoplasmic translation"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_eL20"/>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
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        <property type="entry name" value="RplX-like"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000456519" description="Large ribosomal subunit protein eL20">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="35613268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW28933.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7PZY"/>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="7Q0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q0P"/>
        </source>
    </evidence>
    <sequence length="172" mass="20338" checksum="E864C2AF2010F250" modified="2017-01-18" version="1">MSRLNEYQVIGRNLPTESVPEPKLFRMRIFAPNTVVAKSRYWYFLQKLHKVKKASGEIVSVNIISEAKPTKVKTFGIWLRYESRSGIHNMYKEYRDVTRVGAVETMYQDLAARHRARFRSIHILKVVELEKTDDVKRQYVKQFLTKDLKFPLPHRVQKSKKLFQATAPTTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLH8</accession>
    <name>A0A1D8PLH8_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">HOS3</name>
        <name evidence="4" type="ordered locus">CAALFM_C402300WA</name>
        <name evidence="3" type="ordered locus">orf19.10288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720522.2">
        <property type="nucleotide sequence ID" value="XM_715429.2"/>
    </dbReference>
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    </dbReference>
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        <property type="gene designation" value="HOS3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_02300W_A"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDAC_HD_type_1"/>
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        <property type="entry name" value="HDACs"/>
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    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
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        <property type="entry name" value="Ureohydrolase_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="225"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="517"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0000178358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AOW29001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="713" mass="81944" checksum="F6D530D767908250" modified="2017-01-18" version="1">MSTSKNTLSNHDNDSEDSLIEAFETTLTIRPTTTEYEDNDISIDHTTLPHTTINSINYTRDASIVDIEELEENEQISEQIPKFKTKRRYSLLPKITAFKKTGSPGLEEYYNQQKLDPKFDAILKPSVLLDESLIKYNHAFDEFLRSNPHIENESPRFVHDSNKTLIVLSPYSAEHAFGRKWVTKSYLSTIFERPQRLLASCIGVASAVSMFPFYYKVINSTKRGSVFSSHVRKIHGRNWPKKLFELCLESHEKLNNDELEVPEDWNVGDIYLTPKTINAIEGVIGTIESAVDSLFSKRKKENHNLAFVVIRPPGHHSHACLPSGFCLLNNVQIGIEYAFEQYGVTHCAILDIDLHHGDGSQDICWERAGFTGDYGQQEEDEIVDPKLNPRDDYGKRFATYPKVGYFSIHDIKSYPTEIGYATKENIKNASTCIMDHDLNIWNVYLQEWSNEEEFYKHYQTKYVAILNRANQFLNSAKKQYEQEYEEYLDNLGKYNKYLLKPHLYSQPLTKPTPPPPFKPLIAISAGFDASQYENPQMQRHGINVPTSFYSTFTKDVVKLAKIHTNGKVLSFLEGGYSDGALSTGIFSHLIGLNNDDEFLWNHSWGSQQVMKELVKGCKKNWSPYKKPQSDITIWANEVIKLGRAMMPNAILPTNYVYDDQTKQLNRPINKMVKELMDSRGEAVEVSSPIRKDPEDDRKVMRHTRSYYKKVSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PLM0</accession>
    <name>A0A1D8PLM0_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beclin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAALFM_C402670WA</name>
        <name evidence="6" type="ordered locus">orf19.10246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AOW29035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_715390.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PLM0"/>
    <dbReference type="SMR" id="A0A1D8PLM0"/>
    <dbReference type="FunCoup" id="A0A1D8PLM0">
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    </dbReference>
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    <dbReference type="GeneID" id="3637830"/>
    <dbReference type="KEGG" id="cal:CAALFM_C402670WA"/>
    <dbReference type="CGD" id="CAL0000196120">
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
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        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:cellular response to nitrogen starvation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:late endosome to vacuole transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
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        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
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        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="APG6_N"/>
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    </dbReference>
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            <end position="325"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000196120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="517" mass="60214" checksum="43F38FB1F563F965" modified="2017-01-18" version="1">MSNNQVFECQKCDTPLNLDQSLLNLNESQLKLLVSQKKHKLFRKANSQILKDLDPQDYIPQDRLEMYQGITNQEPINHRNYFESEDDEDDEYEDEEQNNQQQKLHDSGFTSDSNSYLVLNESDEFKENIKNSHDGDDTEDRSTDERNDFRMSTRIKTLNKIFAILSNNQEIDHPLSEDCAKLLIENYQLKFDQSQKEKETYLSFLRKLKDKDSQLNLYNEDDENNEIVNPDLLHQDLDQKLYQSIQEFQKLSVQEKENLKELKKLEQTKTELETQLSNYEQELNNLRENGLNSILKLKNKLQLELNEKNKKLEQSKAAYDVQLDHIDKLRNLNIYTRIFHISCDSQDKFATINGFRLGHKIIWPEINAALGQIVLLLVFLIKRLKLDLKNYKLVPMGSQSQIIKFSAKDAVDGTTKSKTILNLYSSDEFSLGKLFNFNKLDVAMIALLDIVSLIEAKVLSIDQEIELPYKIKNDTIGGKSIRVTSNSEWTSSCKFLLTNLNWILTFVSAHTNSEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM01</accession>
    <name>A0A1D8PM01_CANAL</name>
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        <submittedName>
            <fullName evidence="5">Axl2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">AXL2</name>
        <name evidence="5" type="ordered locus">CAALFM_C404170CA</name>
        <name evidence="4" type="ordered locus">orf19.12750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_712003.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM01"/>
    <dbReference type="STRING" id="237561.A0A1D8PM01"/>
    <dbReference type="GeneID" id="3641184"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404170CA"/>
    <dbReference type="CGD" id="CAL0000174439">
        <property type="gene designation" value="AXL2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04170C_A"/>
    <dbReference type="eggNOG" id="ENOG502QURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM01"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cadg"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="318"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
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        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="818"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000174439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOW29166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="933" mass="101901" checksum="DBB0059A512E7255" modified="2017-01-18" version="1">MGFPFNEQLPNIGRVNKDYSFTIANTTYKSNSDGVISYQVENLPSWLSFDSSSRTFTGKPQESDVGSFEITLIGTDSTDQSQLSNNYTMMVSNDTGLYLTSQALLYSELSKSGQTNGNGGLVVKPGDKIKIQFEKNLFKSYSSSDRPIIAYYGRSADRSSLPNWIYFDGDTLTFSGTVPYVTSENAPSIDYSFSFIASDYYGFAGAEGKFKIVVGGHQLSTSMNETNIVNGTIGSKIDESIPILSDVFLDGQPISKENISDIYDQDLPNYATFDKNNFTITGTFPNTSTTDNFTIVVKDIYGNSVELPYSFDVVNSIFTIDSLKDVNATRGQYFQYQILKSYFTDAEDTKVTVDFGSGTNSDWLQYHDSNMTLSGITPKNFNSLKVEINAESNSDKESKSFQIKGVDKKIVSSSSSSSSTSSSSSTASASSSFGSSESSSSPIAHKKSNKNKALAIGLGVGIPVFLILVAALILLCCCLKRRKNKNNENNTNDNDEYFNEFKQPRKPMPPINGIAGAGAGAGAGALALAAGAGAIVATSSNESIKDESTMNVFKLEHNYSKSSSSLTQVETSSSESFYDTHENTPIVKSWRANTESDSKLARISNGSLATVNTENLFSVRLIDDYSVRNSETSSKFLSSNSLNALLRRESLSNNNSNNSTNFQRLDSNGNIVGELNFNNNNNPKSNRSSSSEKYMTQLSSPLPPPSLPQSQANLHIVPEEKSRDLSHTGKDETTGTISNLLLQFNDNRSKVSDDEFNSSSRVKQQQQQQHQHPLSRENSFSNHYDFDNRLPSPNYALGTNSSTMVSPSSDTFLLDESTPINNNHITNTTTAPTTTTTNSNPNNNNNNQDGQTMQHQNLSAISLGSINSDKFFFDKNHTNANKNSPSSTPNSLNIGKSAKLVDFTRKGSLRESAYEPDYIYTGQSASIQIDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PM29</accession>
    <name>A0A1D8PM29_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">SEC15</name>
        <name evidence="11" type="ordered locus">CAALFM_C404290WA</name>
        <name evidence="10" type="ordered locus">orf19.8994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_711547.2">
        <property type="nucleotide sequence ID" value="XM_706455.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PM29"/>
    <dbReference type="SMR" id="A0A1D8PM29"/>
    <dbReference type="FunCoup" id="A0A1D8PM29">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PM29"/>
    <dbReference type="GeneID" id="3646845"/>
    <dbReference type="KEGG" id="cal:CAALFM_C404290WA"/>
    <dbReference type="CGD" id="CAL0000198871">
        <property type="gene designation" value="SEC15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_04290W_A"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PM29"/>
    <dbReference type="OMA" id="FPFHSEQ"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="9">
        <location>
            <begin position="80"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="8">
        <location>
            <begin position="442"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000198871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="892" mass="103474" checksum="5C766E0E5A70EFCA" modified="2017-01-18" version="1">MPSTQIRNSKTRTSLNGKYSKQVQNKSNGPVVDSLQLENLLLRDEDIFQTTLNSEDYLESLAPIMKDAIKSNGLSELLVKLNEIVKSKDEELNQASMESMDEINTCINTIDNIHKEANELNKQFIQVSSSLNKSAYELMSKKKNYVKYKDVCERINETQVVLNECIQVLELMNKILELIRQTKYFSALKLIDEIINIHIQKVEDFSFAKKIVDSIPHLTKMVKDESFENLCKWLSINLERKLQDIASGLYNNLDELQNNWSKIKKENGPTFLPYKINSPVELALRDPELNYNVFEDVSLQINLNAVYDAVLVYQTLQELDTLSSAYHKEWMSKYSRVIYPITTASVSKKDVVFDNNELYEYLRKIAAFFVTDKQLNLITKFQLRSNTQADELWLSYMTKLKPVLIQLLKHHNFTNIQELGSFKTIVGEFLQIMDNHDYDISELYEVMMMIFKEYYAPLTIQTFRKQFVASIQSDRYRPLTVTDEADYTAIMQNVWYKDDASFAPAYVKSFPVTFPFSEDYVHYCIQVRRLLKDVLRFIGDYYNYEIGELTNTIVNNIIEVVLSDEKGYGIAYEIEEFITRNENNKEITAQTYTNLEYYLFSLYEIGKLVNRELRKHTGMGVHNIDANDTFTLRAVETFNKLKKHAEETVFKMVDNKINELLDMVEYDEYLPVEKNDEANFAIKDFALFLENLFTSIFNNLPSQLRTLGLFRTYDFVSEYFLNVLKDANVYNRIFVANFDLDIQYLETSLRNLHGFKEDGDEANGNGGNVALESTFTELRQCIDLLNLEDYEEFINDSSFRMRRFDRVKYEDGINLIKKMQDNESKQQTSVSAMSERGTIGGVIPNSSSTRSFVNMLSNLSTDDAGNTSSGSIESTSTTSKLAQFTTRFKQNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2025-02-05" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMB8</accession>
    <name>AK_CANAL</name>
    <protein>
        <recommendedName>
            <fullName>Aspartokinase</fullName>
            <ecNumber evidence="1">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HOM3</name>
        <name evidence="9" type="ordered locus">CAALFM_C405540WA</name>
        <name evidence="8" type="ordered locus">orf19.8820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Eukaryot. Cell" volume="9" first="717" last="728">
            <title>Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants.</title>
            <authorList>
                <person name="Kingsbury J.M."/>
                <person name="McCusker J.H."/>
            </authorList>
            <dbReference type="PubMed" id="20305002"/>
            <dbReference type="DOI" id="10.1128/ec.00044-10"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="journal article" date="2010" name="Eukaryot. Cell" volume="9" first="729" last="737">
            <title>Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation.</title>
            <authorList>
                <person name="Kingsbury J.M."/>
                <person name="McCusker J.H."/>
            </authorList>
            <dbReference type="PubMed" id="20305003"/>
            <dbReference type="DOI" id="10.1128/ec.00045-10"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates aspartate, the first step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:23777"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Sensitive to sulfometuron methyl (a compound that increases flux through the threonine biosynthetic pathway) (PubMed:20305002). Does not decrease survival in a mouse model of infection (PubMed:20305003).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716543.2">
        <property type="nucleotide sequence ID" value="XM_711450.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMB8"/>
    <dbReference type="SMR" id="A0A1D8PMB8"/>
    <dbReference type="FunCoup" id="A0A1D8PMB8">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMB8"/>
    <dbReference type="EnsemblFungi" id="C4_05540W_A-T">
        <property type="protein sequence ID" value="C4_05540W_A-T-p1"/>
        <property type="gene ID" value="C4_05540W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3641771"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405540WA"/>
    <dbReference type="CGD" id="CAL0000181037">
        <property type="gene designation" value="HOM3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05540W_A"/>
    <dbReference type="eggNOG" id="KOG0456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMB8"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0791">Threonine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000461579" description="Aspartokinase">
        <location>
            <begin position="1"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="463"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P10869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20305002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20305003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="20305003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="CGD" id="CAL0000181037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="AOW29286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW29286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="544" mass="59589" checksum="FBA7E66D2EFCC6D3" modified="2017-01-18" version="1">MSQSPTNVPRSYNSVLDLKLASPTNSASGATGGWIVQKFGGTSVGKFPENIVDNIVKVYSQTNRVAVVCSARSSQTKSEGTTSRLLRSADLAENDKDYQPLLNAIEEDHVTNAERIQSEEIKQELIKDTKQEIEHVRELLHACQIIGEISPRSLDSIMAVGEKLSCLFMTALMKDHGLNAVYINLQDVIPLSYDFQKGFDDSFYQFLSQEIGKRVLQCDKEREGEEDVIPVLTGYFGVVPGGLLNGVGRGYTDLCAALAAVALQADELQIWKEVDGIFTADPRKVPNARLLDSVTPEEAAELTYYGSEVIHPFTMEQVIRAKIPIRIKNVENPTGKGTIIYPDNIGRRGEATPPHPPAAFEQLAMSSLLQRKRSATAITAKQDIVVINIHSNKKTLSHGFLAHVFTTLDKYKLVVDLISTSEVHVSMALSIQSDQESQLKHALVDLRKMGTVDVTKKMTIVSLVGKQMVNFIGIAGNMFKVLADEKINIEMISQGANEINISAVINEKDTIRALKSIHAKLLEGGSAIGDSSAVDTRLEALKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PMC9</accession>
    <name>A0A1D8PMC9_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">GYP2</name>
        <name evidence="7" type="ordered locus">CAALFM_C405600WA</name>
        <name evidence="6" type="ordered locus">orf19.8829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017626">
        <property type="protein sequence ID" value="AOW29292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716552.2">
        <property type="nucleotide sequence ID" value="XM_711459.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PMC9"/>
    <dbReference type="SMR" id="A0A1D8PMC9"/>
    <dbReference type="FunCoup" id="A0A1D8PMC9">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PMC9"/>
    <dbReference type="GeneID" id="3641780"/>
    <dbReference type="KEGG" id="cal:CAALFM_C405600WA"/>
    <dbReference type="CGD" id="CAL0000194959">
        <property type="gene designation" value="GYP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C4_05600W_A"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PMC9"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="241"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0000194959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AOW29292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="942" mass="108199" checksum="335DE846290DC546" modified="2017-01-18" version="1">MAFFDSLKDKALNTLNQVLSTNNKNQMVLTKDQLFCQQYNLPDNEVVIYESAAEINIVSAYSHDSCKNNNDPFPQGRLYLTPHFLIFRDAYDRKSCSFTIHLSTIKKVERLVSTDYGFALSITTYSKLTITLYLVGIRSESERFAQNLTISLRKNLSNVGKLQPFIQTCYSEYLLSKNKVSSEKVEHMPAGGLGLVFKFPGNPKESKDKTKLKMWFDLFQTDGRNLSLVRKPLFYKLIRVGLPNRLRGEIWELTCGSMYLRLEHQGEYIQLLEEHKDKKSFAIEEIEKDLNRSLPEYAAYQSPEGIERLRRVLTAYSWKNPDVGYCQAMNIVVAALLIYMSEEQAFWALNVLCDRIVPGYYSKTMYGTLLDQKVFESLVQNTMPMLWEHITKNDIQLSVVSLPWFLSLYLSSMPLVFAFRILDIFFMQGPKTLFQVALAILKQNGEELLQTEDDGTFISIIKDYFHTLDQSAHPNSPNPKYRSVTKFQELLVTAFKEFSTVNEDMINTHRNKHRDSIYQNISTFVKRTEIRNLPRTSNIPPDTLDILYDRFYSQVEVSNITKGSGSSYMDFKAFLKFMSEICDWVQFVDPKDETNERHFLRRLYNNWDSEQQGVLTFSDLVVGLNSLVDPDLMASMSNYFELYDTNHNGKLNSEAILQISEDLLYITSPWKEGYLLDEITRLAVENEVAEEVFKNQVANGDGLTIDLPQHVEVNREKIEQQQIERYLRAASTFIQRAFEYAQPEDQELLIKDLAIDEKLSHNAALNPNTPVYLNLPTFRMVILADETYELLFSHTLREATHLNRPLDSSFNPMRNLRDMFDGLLADGRKVANKVRLRMDSRASNPGGSSSASVKSNKSTSKTGAGDEDDERDDDFGMISIDEQDKDLLLGAEAQSLVDPIKSEVAAANTLERFHRAESEARNHIHKDGANGNHTENLIEFEQ</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
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            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
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        </location>
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        <location>
            <begin position="183"/>
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        </location>
    </feature>
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        <location>
            <begin position="183"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_716761.2"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A1D8PP07"/>
    <dbReference type="FunCoup" id="A0A1D8PP07">
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    <dbReference type="GeneID" id="3636393"/>
    <dbReference type="KEGG" id="cal:CAALFM_C504610WA"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="entry name" value="Csn12-like"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
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        <source>
            <dbReference type="CGD" id="CAL0000191406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW29867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="476" mass="55112" checksum="1C342E0725175638" modified="2017-01-18" version="1">MTRKRKVEKKILHINTEYSNSSYHTNHLFVIMSELVNYIHEFGTALKEENPSDFIKCITISPTITIANTRKEFPEPNDVDLFHIPEKFRPVLKCHIQLMKAVYNEKSLDKAFDVLNQLILNLIMASDFLTNWINRPLIKSLSELVAIYKTKESRNPEDLDSFIEDDADAFGGTTQSQKSCLESLVITFRKACQLSLGDKNLDSELTKRNDVYYFLANFVKYCFKLGKLDLAKSVIKAVKNISNRLPALDSTVKTKKYGVIYLYYQALMALDDGDYIESEENLEYAMKLMDDYQDLKSNQLGQILLVLIPLKLHNHGQFPSKKIWLKYPVLRSLYRDNFLKAILEGNIARFNQSSEKFQIILLKKHLYVLIEMLRPLVHLQLIKKTYRLIMELNSDSKSKHLVPISAFQLALEYSTFNKDYECDFNFAGDHLYAISKSETECILGYLISKGRIRAYLSTLKEGYVVFAKTDTFPKPQ</sequence>
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    <accession>A0A1D8PPI5</accession>
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            <fullName evidence="11">Lysine/arginine permease CAN1</fullName>
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        <alternativeName>
            <fullName evidence="12">Basic amino acids permease CAN1</fullName>
        </alternativeName>
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    <gene>
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        <name type="ordered locus">CAALFM_C600960WA</name>
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    <organism evidence="13 14">
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1993" name="Curr. Genet." volume="24" first="487" last="490">
            <title>Transport properties of a C. albicans amino-acid permease whose putative gene was cloned and expressed in S. cerevisiae.</title>
            <authorList>
                <person name="Sychrova H."/>
                <person name="Chevallier M.R."/>
            </authorList>
            <dbReference type="PubMed" id="8299168"/>
            <dbReference type="DOI" id="10.1007/BF00351710"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1997" name="FEBS Lett." volume="408" first="89" last="93">
            <title>Biogenesis of Candida albicans Can1 permease expressed in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Matijekova A."/>
                <person name="Sychrova H."/>
            </authorList>
            <dbReference type="PubMed" id="9180275"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(97)00396-7"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1999" name="FEMS Microbiol. Lett." volume="176" first="257" last="262">
            <title>Degradation of Candida albicans Can1 permease expressed in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Matejckova-Forejtova A."/>
                <person name="Kinclova O."/>
                <person name="Sychrova H."/>
            </authorList>
            <dbReference type="PubMed" id="10418152"/>
            <dbReference type="DOI" id="10.1111/j.1574-6968.1999.tb13670.x"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="1076" last="1087">
            <title>Transcriptional response of Candida albicans upon internalization by macrophages.</title>
            <authorList>
                <person name="Lorenz M.C."/>
                <person name="Bender J.A."/>
                <person name="Fink G.R."/>
            </authorList>
            <dbReference type="PubMed" id="15470236"/>
            <dbReference type="DOI" id="10.1128/EC.3.5.1076-1087.2004"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2009" name="J. Infect. Dis." volume="200" first="307" last="313">
            <title>Time course global gene expression analysis of an in vivo Candida biofilm.</title>
            <authorList>
                <person name="Nett J.E."/>
                <person name="Lepak A.J."/>
                <person name="Marchillo K."/>
                <person name="Andes D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19527170"/>
            <dbReference type="DOI" id="10.1086/599838"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="995" last="1013">
            <title>Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.</title>
            <authorList>
                <person name="Bonhomme J."/>
                <person name="Chauvel M."/>
                <person name="Goyard S."/>
                <person name="Roux P."/>
                <person name="Rossignol T."/>
                <person name="d'Enfert C."/>
            </authorList>
            <dbReference type="PubMed" id="21414038"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07626.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2012" name="Cell" volume="148" first="126" last="138">
            <title>A recently evolved transcriptional network controls biofilm development in Candida albicans.</title>
            <authorList>
                <person name="Nobile C.J."/>
                <person name="Fox E.P."/>
                <person name="Nett J.E."/>
                <person name="Sorrells T.R."/>
                <person name="Mitrovich Q.M."/>
                <person name="Hernday A.D."/>
                <person name="Tuch B.B."/>
                <person name="Andes D.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="22265407"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.10.048"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">High-affinity permease for basic amino acids arginine, lysine and histidine (PubMed:8299168, PubMed:9180275).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="4">Degraded in the vacuole after internalization by endocytosis in a ubiquitin-dependent manner when expressed in S.cereviae (PubMed:10418152).</text>
    </comment>
    <comment type="induction">
        <text evidence="5 6 7 8">Expression is induced during phagocytosis by host macrophages (PubMed:15470236). Expression is also induced during biofilm development (PubMed:19527170, PubMed:21414038, PubMed:22265407).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_714306.1">
        <property type="nucleotide sequence ID" value="XM_709213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPI5"/>
    <dbReference type="SMR" id="A0A1D8PPI5"/>
    <dbReference type="FunCoup" id="A0A1D8PPI5">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPI5"/>
    <dbReference type="GlyCosmos" id="A0A1D8PPI5">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="C6_00960W_A-T">
        <property type="protein sequence ID" value="C6_00960W_A-T-p1"/>
        <property type="gene ID" value="C6_00960W_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3644035"/>
    <dbReference type="KEGG" id="cal:CAALFM_C600960WA"/>
    <dbReference type="CGD" id="CAL0000201116">
        <property type="gene designation" value="CAN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_00960W_A"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PPI5"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015802">
        <property type="term" value="P:basic amino acid transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000439803" description="Lysine/arginine permease CAN1">
        <location>
            <begin position="1"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
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            <dbReference type="PubMed" id="10418152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15470236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19527170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="21414038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="22265407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="8299168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="9180275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="8299168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW30042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="571" mass="63331" checksum="7AB5E7B7B272C9D1" modified="2017-01-18" version="1">MPEDYEKYRMGSSNESHQKSVQPISSSISKSNKKTKHQTDFVQDSDIIEASSINDEFGEVKRDLKARHVSMIAIGGTIGTGLFISTGSLLHTTGPVMSLISFLFVTTICFSVTQSLGEMATYIPISGSFAQFVTRWVSKSCGAANGWLYWFSWAVTFGLELSVVGQVIQFWTDAVPLAAWISIFFVILTIFNFFPVKFYGEVEFWIASIKIIAVFGWIIYAFIMVCGAGKTGPVGFRYWRNGYAWGDGILVNNNGKYVAAFVSGLINSIFTFQGTELVAVTAGEASPRALRSAIRKVMFRILVFYVLCMLFMGLLVPYNDPKLTQDGGFTRNSPFLIAMENSGTKVLPHIFNAVIVTTIISAGNSNIYSGSRILYGLAQAGVAPKFFLRTNKGGVPFFAVAFTAAFGALGYLACSSQGNKAFTWLLNITATAGLISWGFISVSHIRFMKTLQRRGISRDTLPFKAFFMPFSAYYGMVVCFIVVLIQGFTVFWDFNASDFFTAYISVILFVVLWVGFHFFFYGFGKDSFKMSNILVPLDECDIDSGVRDINDAEFDIPPPKNAWDKFWAIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PPN3</accession>
    <name>A0A1D8PPN3_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase gamma</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAALFM_C601550CA</name>
        <name evidence="18" type="ordered locus">orf19.10935</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716738.2">
        <property type="nucleotide sequence ID" value="XM_711645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PPN3"/>
    <dbReference type="SMR" id="A0A1D8PPN3"/>
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        <property type="interactions" value="810"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PPN3"/>
    <dbReference type="GeneID" id="3641653"/>
    <dbReference type="KEGG" id="cal:CAALFM_C601550CA"/>
    <dbReference type="CGD" id="CAL0000176297">
        <property type="gene designation" value="orf19.10935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_01550C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PPN3"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032043">
        <property type="term" value="P:mitochondrial DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000007">
        <property type="entry name" value="DNA polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000797">
        <property type="entry name" value="DNA_pol_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="17">
        <location>
            <begin position="748"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1154"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1154"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1166"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0000176297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AOW30095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1229" mass="140818" checksum="5F07ACF35E71783F" modified="2017-01-18" version="1" fragment="single">MSNRRLLLRGITRSHRSFVTSLRRRQQQQQQQQSSQQLQQQHPLQQFTEEPRVNQLGIQYLSNDLHKKVFPTTSTKDYLSPQHPQLLEISKKHLQENELLGKKTQITEPITIKNFPSLVGKSMDEHFNKLGQKSSDPYLAMATNFLKKELPCKPPKSQWKFQSGWTRYTKDGNPPEQVPYPLEDTLVFDVEVMYKISNYPVMATCASNEAWYSWVSPALLDWEKQKNNSITTDQIDWNHLIPMNCAKKPKVIIGYNVSYDRARILEEYNIKQTKAFYLDGMSLHVATSGICSRQRPKWAKYNKVKKLSQEDVDEIEGTMEEEEEEEGEMSQELGQLSSESNDVSDYAKLLSDGFQVAVELEVADDPWLLMGAPNSLANVARFHCNIHLDKTDRDYFATEDPNLVIDNFPKLMDYCAKDVDATFEVTKKLFPVFIQRIPHPVSFAALRLLGTLILPTTTKWPKYIEAAESLYESNRQEVATTLQQLANDLVAHIQNKKQVKPDYENDPWLSQLNWKLKETRLKKDGTPYKKTAYMTGYPEWYRELFKTSKGEEMNLTLKTRITPLLLRLKWEGHPLFWVDSQGWCFKVPFDDDNEIARLTEKKYVQPKLTEEELMETRDALLTKGKSYVLFKVPHPNGPSSRCTHILSKLYVRNFEDGTLTSEYDYATKILNLNNEASYWLGNRNRIKDQFVVYNQQGKNKFFDTIKKSKEHSSMGIIIPNLATMGTITRRATENTWLTASNAKKNRIGSELKSLVEAPKGYCFVGADVDSEELWIASLVGDSMLQIHGGTALGWMTLEGEKSQKTDLHSKTASILGISRNDAKVFNYGRIYGAGVKFATRLLKQFNANITDEEADKVARQLYDSTKGRTAVSKYLPSRIYYGGTESIMFNALEAIAQQEEPKTPVLGASITDALNVKNLNTNQYMTSRVNWTIQSSGVDYLHLLIISMEYLIEKYGIDARLAITVHDELRYLVKETDKYKAALLLQISNIWTRAMFCEQLGIKEVPQSCAFFSEVDIDHVLRKEVSMDCVTPSNPTPIPLGESLNIGQLLSKCQHGDILADKNTKPLTLRTTKYSPRQPIINQLDKNLTIAEKIAKIELQTSIDKDEWKKNLYNLAKVSRNKQNGKNNSTEKPQRVIKRKPIVEYDLQEDNNKKREIKYKKDPPKSKIATTTTTTTTKKASSNNSKTKSNVKVDESKSAMTILDLKTDQQRPTYNNRKIVYIGNPQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ16</accession>
    <name>A0A1D8PQ16_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAALFM_C602990WA</name>
        <name evidence="2" type="ordered locus">orf19.13024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719140.2">
        <property type="nucleotide sequence ID" value="XM_714047.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ16"/>
    <dbReference type="SMR" id="A0A1D8PQ16"/>
    <dbReference type="GeneID" id="3639193"/>
    <dbReference type="KEGG" id="cal:CAALFM_C602990WA"/>
    <dbReference type="CGD" id="CAL0000185102">
        <property type="gene designation" value="orf19.13024"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_02990W_A"/>
    <dbReference type="InParanoid" id="A0A1D8PQ16"/>
    <dbReference type="OrthoDB" id="10340886at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000185102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="563" mass="63858" checksum="8A98C8571C7D4805" modified="2017-01-18" version="1">MESSNNQPVPRLTTSDLRDIINNIQKSWQTSNNNSLIPPESQLSPEIQQWIKKTVPTLISLAKTDENFNFPINEGFNDLIRRFLQLPTIRRELISVHPYFIALLRFPAIDASFYHRILDPNYLKINWDATEFVLKRSFIIPEGGEYRNQVKGTPLPTGGRIRPPASIQAQNDMFVQIMNSATNGNGNMNGQNWPNRPAPPPVTPAVPVPTVNGVQNIQNVANLQNDPNNGSLVKLPLSTQLFSEGIPAHSRLTKFFFPDALPDDLTVDSVEQEMSVEEFKLCFASSCKYYRWGVYRTPNFVYLDCTIGKLHFTPEFPNENLNSGCPAQIKLKVENNRIKMTYLFHHNHSFLKCEKDNVPTLKKDPVRAWLIEQALQGKDWAWVKANKEGINIAGDVEDIDLSKRINRKLYFQICRLLGAETPPDEPDESEESAPESVSPSTTANDQRESGYMFDDETHGLVQNNSYDFPTNDFHHGLSESSPANFDIPNFGQSDDDDEGEGAETEANNRRALKAECEGILKYVESTMESAFEMLPVQRLHDLKEFMKNTAKQMEQEFSSNHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ75</accession>
    <name>A0A1D8PQ75_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="6" type="ordered locus">CAALFM_C603620CA</name>
        <name evidence="5" type="ordered locus">orf19.13152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718068.2">
        <property type="nucleotide sequence ID" value="XM_712975.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ75"/>
    <dbReference type="SMR" id="A0A1D8PQ75"/>
    <dbReference type="FunCoup" id="A0A1D8PQ75">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ75"/>
    <dbReference type="GeneID" id="3640297"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603620CA"/>
    <dbReference type="CGD" id="CAL0000194762">
        <property type="gene designation" value="orf19.13152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03620C_A"/>
    <dbReference type="eggNOG" id="ENOG502QR5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ75"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="123"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="331"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0000194762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW30291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="513" mass="57598" checksum="A2D81229AB6A1348" modified="2017-01-18" version="1">MSLNPALKFRDFIQVLKNEGDLVEIDTEVDSNLEVGAITRKAYENKLAAPLFNNLKQDPGNIDPKNLFRILGCPGGLRGFGNDHARIALHLGLDSQTPMKEIVDFLVANRNPKKFIPPVLVPNEKSPHKKHHLTHEQIDLTKLPVPLLHHGDGGKFIQTYGMWVLQTPDKSWTNWSIARGMVHDSKSITGLVINPQHVKQVSDAWVAAGKGDKIPFALCFGVPPAAILVSSMPIPDGATEAEYIGGLCNQAVPVVKCETNDLEVPADCEMVFEGYLDRDTLVNEGPFGEMHGYCFPQDHHTQPLYRVNHISYRDEAIMPISNPGLCTDETHTLIGGLVSAETKYLISQHPVLSKIVEDVFTPYEAQALWLAVKINIQELIKLQTNAKELSNLVGDFLFKSKECYKVCSILHEVILVGDDIDIFDFKQLIWAYTTRHTPVQDQVYFDDVKPFPLAPFISQGPLIKTRQGGKCVTSCIFPKQFTDPDFKFVTCNFNGYPEEVKNKVFQNWEKYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQ76</accession>
    <name>A0A1D8PQ76_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase I termination factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C603550CA</name>
        <name evidence="7" type="ordered locus">orf19.13145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718060.2">
        <property type="nucleotide sequence ID" value="XM_712967.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQ76"/>
    <dbReference type="SMR" id="A0A1D8PQ76"/>
    <dbReference type="FunCoup" id="A0A1D8PQ76">
        <property type="interactions" value="1305"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQ76"/>
    <dbReference type="GeneID" id="3640246"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603550CA"/>
    <dbReference type="CGD" id="CAL0000184035">
        <property type="gene designation" value="orf19.13145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03550C_A"/>
    <dbReference type="eggNOG" id="KOG0051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQ76"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="478"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="480"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000184035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="62818" checksum="8725525FB039F2D1" modified="2017-01-18" version="1">MKENQHESGAHALLKLGTKRENDNDNEAAQNNHINDAVEAAVMKYVGGTLGSHDSKKKRKHDADDYAFAQWTGFLDDNFMNEASSDAVAPSSTPPKKKKKKDKKKDKEKDKEKKKDKEKKKEKKKKKEKKKKKEKKKDKKDKKKKKKHRHRDHDEHAKNEEGPEQGDELTRHIEVEDSAVKENADTGYAADRNTVEKSTEERNIKVRNVDQGNTRAGPTVEEKNQFHDIDEAQSKLIEAAIQNAHGLTHELNEAQEQRILEAANEVVASESFLNNDITLPNMGSQSNFSFTLNTFPVPVTATQDETKTRKRDIPKEPHKLPEYDFSTLSDVQTLTKDIYKKTLEWYNQNVKPEDRKKPRAFSPEEESYLDYYLAGYCHLTKMNREDLCQRVWASGVIKDGFWRNIYKVFSYRSVSSVYKHVRRKFHIFDVRAKWTKSDDEQLKQLTLTYPSKWKQIGELMGRMPEDCRDRYRNYLVVGENRKKSNWTQDEVDKLMAIVDEQLAVVSTVNWTLVAEKMGTRSRIQCRYKWNRMKGINQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQA6</accession>
    <name>A0A1D8PQA6_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">5'-AMP-activated protein kinase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">SNF4</name>
        <name evidence="18" type="ordered locus">CAALFM_C603920WA</name>
        <name evidence="17" type="ordered locus">orf19.13191</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_718103.2">
        <property type="nucleotide sequence ID" value="XM_713010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQA6"/>
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    </dbReference>
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    <dbReference type="GeneID" id="3640264"/>
    <dbReference type="KEGG" id="cal:CAALFM_C603920WA"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_03920W_A"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:nuclear envelope lumen"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cellular response to glucose starvation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006110">
        <property type="term" value="P:regulation of glycolytic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:2000217">
        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000033">
        <property type="entry name" value="Nuclear protein SNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
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            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="276"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056256"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0000191335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AOW30318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="336" mass="37686" checksum="0362ED340A0E60D8" modified="2017-01-18" version="1">MTDIAPPSAATPNDYILSLSPEQIEHDQKIGIKAIRLFLQSKTSYDVLPVSYRLIVLDTSLLVKKSLNILLQNNIVSAPLWNNQTSRFAGLLTSSDFINVIQYYLQFPEKFELVDQLTLGGLREIEKAIGVDQIETASIHPFKSLYEACVKMLESKARRIPLIDEDEKTKREIVVSVLTQYRILKFVALNCKETKMLLKPLKNLSGLGDVKKLSTCTMDTPVIEVIHLLTENSVSSIPIVDGQGKLINVYEAVDILALVKGGMYTDLDLSVGDALLRRSEEFEGVHTCTLNDRLSTIMDTIRKSRLHRLFVVDDEGKLVSVITLSDILNYILFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQD2</accession>
    <name>A0A1D8PQD2_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">CDC39</name>
        <name evidence="17" type="ordered locus">CAALFM_C604270WA</name>
        <name evidence="16" type="ordered locus">orf19.8685</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_712097.2">
        <property type="nucleotide sequence ID" value="XM_707004.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PQD2"/>
    <dbReference type="SMR" id="A0A1D8PQD2"/>
    <dbReference type="FunCoup" id="A0A1D8PQD2">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PQD2"/>
    <dbReference type="GeneID" id="3646278"/>
    <dbReference type="KEGG" id="cal:CAALFM_C604270WA"/>
    <dbReference type="CGD" id="CAL0000177338">
        <property type="gene designation" value="CDC39"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C6_04270W_A"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQD2"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000008">
        <property type="entry name" value="Subunit of the CCR4-NOT transcriptional complex, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000008">
        <property type="entry name" value="Subunit of the CCR4-NOT transcriptional complex, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032195">
        <property type="entry name" value="CNOT1_HEAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16419">
        <property type="entry name" value="CNOT1_HEAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat 1" evidence="14">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="256"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="456"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="651"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="15">
        <location>
            <begin position="1264"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1602"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1715"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="923"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1680"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="923"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1694"/>
            <end position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0000177338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AOW30345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="2016" mass="228525" checksum="1144DF26940F2424" modified="2017-01-18" version="1">MSFKELLIEIGPENLLPEKLLPSLLQIKPNEIDQGIALILAEILIPGSQGLSQGLTFASSLPGSNAKGAQLQTCFKSIENSGKFNVNWYEVFNHVHQYLFDSSQRDIQPSVGSITQFLSSLDFKQEPIDIFLNYEWWFNKTLLYILHSSDASQGGYDISLSPNLAYCFEEDKTTPQTRRNILKFINVGKLEIQVITKIQQQQQQQQQQQQQQHQLSEQDKKLNAFLNQLFEHDYRVFPEYILAAALTVVEKSQFINDLIDTLFYLLVDSASPSLPKVVRLLKESGLAAIKLADYYKSRKTIDAADKVLTLASSFGLTQEILDIFWAFDSKIAIKILVESSLFGYDYKSVIDSKLKDPQVKTSIYQALCEALDERAQKDYERGQQVQQAQQLQQQQALPPHQVLKIPTVYYLLEKIKSSNGVVDAKTLRNLQLLLLTTYPRLINFGNGHDEAILANEEKSPFFPPSVEMEMKAYYSKMYNKELEIKEIVDMLTQMKASDDLHSQDVFACMIHSLLDEYKFFSEYPLSALASTSLLFGALLEKDLIQGTTLTVALNFIWESCNQPQDSHLFKFAVQSLYNFKSRLHEYPIYCKHLLECRSLSAHAKMYQIVKDAANGIPCTTGAAPTQTNTPDVGPKYQSINYVDRTIGYATQEEPPESIRDKLLFSVNNMTGENLRLSEIQEVLTESYFAWFSDYLVSDRAKAEPNNHELYSKLVKSLANPIFFEYILNVSLKEVDYIIRNFKDSRSERNQLKNLGAWLGRITLANDKPLRRDYIALKFLLVEAYDFNSLPLILPFVCKILDQAQYSKVFKPPNPWVVGVMKVLAELYECADLKLQLKFEIEVLLNSFNMKIKDIEQSTIIRNHNPEPTALARMFGISSQSVNLANEMTRLSLEGSQLGNNIQAPFPQQIIESKQFPGISQPQMQNVLQQQQQQQQQQQQQQLPPQQQLPGQLPPQQQAEPALDTSFSTLIGNSIFTQHANLRRAFQASLSRAVRECTPHICNKVVETVVTTTKALITKDFATERDIEKFRNSYQKLALSLSHAMVSCNGRKALVETIEATMLQLLGNNPNEVPLAELNSAIQANVGLCVDIVDVLVGESILDIIEARMQTEVFLREHHTATAPNEPFIAEGASDYSLRLPNPLGLALTGLSAQQLKIYEHFGEARVDQIVPPPGSTGITQQQTQSLAPLQQQQQQQQQQQPVSTVVAAAPAPAPPQQQQQSKERIAQAQGVPDDIVSFEQLFTAITANCDKAVQLVSEVTETKLADLPPNHSIMAALTQALVIAQTNAIKYPELLLKAAQYAVNCLFTQTHENPMSNEIYVVILDKLCEYSPSTAKDVIWWLVHSSDQRKFNMPVMLSLLKVQLIQPIKLDLSIGKLIKETNNPVVVKFAASLLTNIFTSEEMRPIALRSEFANTLDALSKYQANDQSEEDRQAKEATSTLFKLLSEAAPASNQLFAQLGYIFAEWVRLLTHGDDATNELQIEFVKGLIQSGILNNPEYVKTFFKAAIEISITSFATEHELRSRTQHETYFAVDTLAMLIVRIVLLVEDSKQAIDYLKKVLGIIILNLINDHETSKANWNERAYFRFFSSLLSTWCDASVLDEEVTVNLDVEFYNYLGELFNALQPIVLPGFTFAWISLISHRMYLPKLLELPERKGYATLVKLLSSALKFQQIYGNNKQSSRRQQELEQEQEQEQKDEKDAKDAKEQNQEQEQEQENSQQGPEVINVTYKAINRIFIGILHDFPEFLVECHYQLVTSIPRGYIQLRNIVLSATPKDIHVPDPFTQGLKVERLPEINESPVVFYKPIEDLSKVGLKKPVENFLRIPAPGLMRTIYNGLKLNQPKEVNELGYEETINFNIKLINALVLHVGISSVADRLPNNRGFNTKSSQVALLVDLMNYGNTEFKYHLINAIANQLRYPNSHTHWFIGIILHFFSNNNIWNSNGNKLVVQEIITRVLLERRISNKPHPWGLTILFTELVKNGDYGFFELPFVKDSVEEVKNIFNVLSINVKGSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PQK1</accession>
    <name>A0A1D8PQK1_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Putative mitochondrial carrier protein PET8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">CAALFM_C700380WA</name>
        <name evidence="16" type="ordered locus">orf19.7082</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Dungan J."/>
                <person name="Kalman S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_720299.2">
        <property type="nucleotide sequence ID" value="XM_715206.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A1D8PQR9"/>
    <dbReference type="STRING" id="237561.A0A1D8PQR9"/>
    <dbReference type="GeneID" id="3637948"/>
    <dbReference type="KEGG" id="cal:CAALFM_C701100CA"/>
    <dbReference type="CGD" id="CAL0000199206">
        <property type="gene designation" value="orf19.6896"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_01100C_A"/>
    <dbReference type="eggNOG" id="ENOG502RPTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PQR9"/>
    <dbReference type="OrthoDB" id="4022940at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000199206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW30483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="512" mass="56937" checksum="A6887F282D032581" modified="2017-01-18" version="1">MSEVPNQESPSSSILKQSNASTSTKIHGAPSSSQIANVDFNTLRKLNTNTSFSSNLTNSTTKTSNALSRLFTRNKSSSNISIHPSSSDDDSLPKTLRESTSPSESSKSTSGNKLRIAKKLKFPKNQSSRKPDMFLDTSSTISEDSSSFRKVIIGNSLNEMNTPRKSSMSSPMSTTFHSLFHRSHHNGSNLQRDTNQVATGTTPLSGKFDDFSKPSKTTLCLSSNSSNSIISNPELAQIYNFTNPNISIEDGETNLDHSNSSFLDIHKKMLVPADSFIQNKLNKYHQTEVGLGIYESELDHDKDSKIYSNFYHYLKPLFTPSFSISDSGQKGKMRPILGASVEEIANFVKESFCLHQPNHERSFRSKTRSSVSSLGREKVEDFDCRQLSNLFEKLMALLSHNLQTAEPLEISLQALILNAWKYYNAYVRFYLLSIFQPLQIYLNELFTRNHNGSKITRIDDLLLASFRKVFITEQGIGSGDRETSKFLGNAESEDLTGNGLLTSTLAVLSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PR73</accession>
    <name>A0A1D8PR73_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAALFM_C702600CA</name>
        <name evidence="12" type="ordered locus">orf19.9908</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710115.2">
        <property type="nucleotide sequence ID" value="XM_705023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PR73"/>
    <dbReference type="FunCoup" id="A0A1D8PR73">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PR73"/>
    <dbReference type="GeneID" id="3648286"/>
    <dbReference type="KEGG" id="cal:CAALFM_C702600CA"/>
    <dbReference type="CGD" id="CAL0000201372">
        <property type="gene designation" value="orf19.9908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_02600C_A"/>
    <dbReference type="InParanoid" id="A0A1D8PR73"/>
    <dbReference type="OrthoDB" id="4026574at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="288"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="835"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="916"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0000201372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AOW30616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="1566" mass="176891" checksum="B1EF149516158E45" modified="2017-01-18" version="1">MNIHNCSKTTFPVENSHSLNASLNVMNFKGLRFNKYLVYDTGATISVVNNKDILSNVKDATIEVSVADGATLEADCVGDLIIRVGIVSITLENTLYLPESSFNLVSLKQIEERGFNVLITKESVIVFNQNVAPTIIASRKNAADLYMGPQFSEESLECDFDYDGLADMLSNANQDDKDKSSMNGMSEYQEHDYSSRALINSLTEVDVLDVEISPYGVEQLLPTGDKNDIYNFHLMSNHMSIEKILLLQKYQGLVLHTSKESLQKIADCKVCLLSNAKQRSHNHHSERKASRRHERLHCDTLGPFRSENNKWYLTSVIDEHTGYIEGIITKDRKVKDLLIQRLKIWNNRFNDKVAYFRSDNAPEFPQPSDLAEFGIWRETIAAYSPELNGLAEVVNKLILQQIYRIVVTLGPQILKLIYYVIQYSITMINHTPRRSLKGQTPYGCYYQLSEGNFYRFPFAIDCVVTFSNAIEKNRYGVTSTKGAPSSIMGAVIGYASDCFSYYVLLKNMRCDIILSPNVRILRSYEVINSYLKNLSTTPMSHIVPMAEGIQGRQSGAQYEVRGTYVESEYDNTNDVMHMPKESYSVQPASFTLTTGNSSNEYVINDDPVQITIENPDDSSNPLQPTEESHDMVSEVKSDENPKPSLHELTPGDNPVSKPPQLGTETSVIGKSKEPITNHTKDAPSIQGRDHKRSESTAQVGLSHQPQTGTPASEESKLSGTDHFGVDVVKETVSEDWHTSDYPETSAEDEQQNPSLSANKNRVTEKIDEGENISFPGGDDDSVVINSNVEQSNVETEDAGNSSIQDEVSQEGRIVNEQTDIVDTVAKAIENEEISPINSLDDHTELATDSGNDSNSTESDIQSKNEISPVINEKNTEIIQKHIESILVDKRLDEFETYNVDEIENVINDDDIAEANPLPDENNNVQMNESSDNNHGMSRAKKKYTFEKEVNEKIAGTKHSLDTTDPREAIRVLNTGETKRIEPKKREIPITVKLNKRSQYKSPYVTRSGRTVINPKRYLHAVVNKIDYNDPGWIKSMNAELEKFRSKDVYEEVPIPTGVKPISMGWVHTEKIDSLKGVVRKSRCVVHGNRQKEKLDYDPFSVSSPVIDLVTIRLLTIIGCELGMTIQHLDVESAYLNASITHSNPIYVFPPKSVPLKRNHCWLLKRSVYGLKQSGFEWYHTIKRVLEDIGFNQVLHNDGLFHIEYEDGSVIYLGLYVDDILMVGSSQKVIDNFVDQLRDHFEVKVFGEISNYLGIEFRKTESGYILSQEKFLKKLLKDFKLDDSYGKNIPWIPNDKYEKVAIIRENVNPENDFEKVPNETLLDPDAKKLYQSGVGSLLWAATNTRPDISVVVNSLGSKSANPNVHDYEKLIYCLRYIKNSMGYHIEYKRNRLNIPPKSFVIECFSDASFAPGLDRKSISGTLIYVNGNLVQWATKKQTVIAQSSAACEMLALNYTMLKAIEIKNNLMDLGFEVGKIHCHQDNQAVIKVLRNNYCHPHRPIDICYKFLRQLINDKVFSISYVKTNDNYADCMTKCLSRAKFKAFVEGMIKRLDLEDNQTSIQNAITAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PRF8</accession>
    <name>A0A1D8PRF8_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4259 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAALFM_C703820CA</name>
        <name evidence="1" type="ordered locus">orf19.7200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_715248.1">
        <property type="nucleotide sequence ID" value="XM_710155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PRF8"/>
    <dbReference type="GeneID" id="3643148"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703820CA"/>
    <dbReference type="CGD" id="CAL0000185769">
        <property type="gene designation" value="orf19.7200"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03820C_A"/>
    <dbReference type="eggNOG" id="ENOG502R5HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PRF8"/>
    <dbReference type="OMA" id="CELWSET"/>
    <dbReference type="OrthoDB" id="4008472at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025355">
        <property type="entry name" value="DUF4259"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14078">
        <property type="entry name" value="DUF4259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0000185769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AOW30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20541" checksum="34DBD6E6DF13F562" modified="2017-01-18" version="1">MGAWGAGYFDSDMSCDCWAELRHENTENALELIITYLQNVVNNNSYIEVDETDAAIVCSLLVIVLFTNYNWINETFTEKDIPKYVQEELEIFLNRYQKNWDENYKNKQIEIKIKIGEQKEVVSIPKLANLSLKQVLNPKISESCELWVETEYYDEWKQRIQILVDKLEQIQTSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSC7</accession>
    <name>ZCF11_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc cluster transcription factor ZCF11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ZCF11</name>
        <name type="ordered locus">CAALFM_CR03050CA</name>
        <name type="ordered locus">orf19.9961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="2668" last="2678">
            <title>Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.</title>
            <authorList>
                <person name="Uhl M.A."/>
                <person name="Biery M."/>
                <person name="Craig N."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="12773383"/>
            <dbReference type="DOI" id="10.1093/emboj/cdg256"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="E1000664" last="E1000664">
            <title>An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.</title>
            <authorList>
                <person name="Elson S.L."/>
                <person name="Noble S.M."/>
                <person name="Solis N.V."/>
                <person name="Filler S.G."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="19779551"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000664"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 7">Transcription factor required for wild-type filamentous growth which is important for the virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Affects the switch between the single-cell (yeast) form and filamentous forms of growth.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The SCF11 mRNA is associated with SHE3 which selectively transports messengers to the buds of yeast-form cells and to the tips of hyphae.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331068.1">
        <property type="nucleotide sequence ID" value="XM_019475523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PSC7"/>
    <dbReference type="SMR" id="A0A1D8PSC7"/>
    <dbReference type="FunCoup" id="A0A1D8PSC7">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CR_03050C_A-T">
        <property type="protein sequence ID" value="CR_03050C_A-T-p1"/>
        <property type="gene ID" value="CR_03050C_A"/>
    </dbReference>
    <dbReference type="GeneID" id="3645109"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR03050CA"/>
    <dbReference type="CGD" id="CAL0000181843">
        <property type="gene designation" value="ZCF11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_03050C_A"/>
    <dbReference type="eggNOG" id="ENOG502R1M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1D8PSC7"/>
    <dbReference type="OMA" id="CVWTLKR"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045991">
        <property type="term" value="P:carbon catabolite activation of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036170">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000463341" description="Zinc cluster transcription factor ZCF11">
        <location>
            <begin position="1"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="454"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12773383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19779551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="19779551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="19779551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW31044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="561" mass="63499" checksum="3CFA08B501D8A86E" modified="2017-01-18" version="1">MKIKQENITNTTSINTSNVNDKPKPKRKKTSRACNHCHKAHMTCDSGRPCKRCIQRGLDSTCEDAPRKRKKYLQDVPNSSLMSNHSMNSSDNLDSNGVSPMQPTLSQPMPPVQESSLPTNIPNQSQVPSQSPNTASQKQLSYSPPLASTYSPNHKTYSATLFQHSATSPELMQTVPEYFPELYNQHYQPSANPNQKRRTNFLSTAADLEYSTLSNILQENFGHHTTSNEGTPNSHNFSPALSPHNMPTNNTNAPSTSTQLLTNDQQRQATSFNNHTKHNTPSPLNTSHTKLYEDARYPKCDETINQYFLGDTDSGKMVVFPDVLTAIENMKNNDPAVYLERNSKSALSFVMSIQHENNSNGGKEDQLFKEPEEIYEKVKKPFSYTPGYHSLIAYLRKRFTKPMLVKMAESMATYRPSFIACTNSLKEHDLIFMEQCFQRTLLTYDNYIKISGTPTIVWRRTGEVAYVGNEFCVLTGWPKEELIGKDKRKFIVELLDDKSVLQYFQVFSRIAFGDFLGATMTECTLLTPNPNVKIRTGCMWTLKRDVFGIPMMIVGNFLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSE1</accession>
    <name>A0A1D8PSE1_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mlc1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">MLC1</name>
        <name evidence="11" type="ordered locus">CAALFM_CR03090CA</name>
        <name evidence="10" type="ordered locus">orf19.2416.1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
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    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SC5314 / ATCC MYA-2876</strain>
        </source>
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</entry>
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    <accession>A0A1D8PST9</accession>
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        <recommendedName>
            <fullName evidence="4 9">Tubulin-specific chaperone A</fullName>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
            <location evidence="2 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TBCA family.</text>
    </comment>
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    </dbReference>
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        <property type="component" value="Chromosome R"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="F:beta-tubulin binding"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBCA_sf"/>
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        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tubulin chaperone cofactor A"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0000174822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AOW31201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="95" mass="11059" checksum="297AB174450CEF75" modified="2017-01-18" version="1">MGPSPLQIKVNALKRLIKEEKLSKQEVAEQEQHINQMKANNADEYELKKQIQVLEESQRMVPEVTKKVAEYRQALKEFLDSYKGDEDVTEAKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PSX0</accession>
    <name>A0A1D8PSX0_CANAL</name>
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        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">VMA13</name>
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                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
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            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
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            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
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                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
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                <person name="Magee P.T."/>
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                <person name="Weissman J.S."/>
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                <person name="Martchenko M."/>
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        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
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                <person name="Martchenko M."/>
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        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
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                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">SC5314 / ATCC MYA-2876</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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            <dbReference type="Pfam" id="PF01545"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8PTB4</accession>
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        <submittedName>
            <fullName evidence="4">Alpha-factor pheromone receptor</fullName>
        </submittedName>
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        <name evidence="3 4" type="primary">STE2</name>
        <name evidence="4" type="ordered locus">CAALFM_CR06610WA</name>
        <name evidence="3" type="ordered locus">orf19.8315</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_06610W_A"/>
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        <property type="project" value="CGD"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0675">Receptor</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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            <end position="231"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="120"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AOW31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="469" mass="52206" checksum="6292D2BC490A9B09" modified="2017-01-18" version="1">MNINSTFIPDKPGDIIISYSIPGLDQPIQIPFHSLDSFQTDQAKIALVMGITIGSCSMTLIFLISIMYKTNKLTNLKLKLKLKYILQWINQKIFTKKRNDNKQQQQQQQQQIESSSYNNTTTTTSGSYKLFLFYLNSLILLIGIIRSGCYLNYNLGPLNSLSFVFTGWYDGSSFISSDVTNGFKCILYALVEISLGFQVYVMFKTSNLKIWGIMASLLSIGLGLIVVAFQINLTILSHIRFSRAISTNRSEEESSSSLSSDSVGYVINSIWMDLPTILFSISINIMTILLIGKLIIAIRTRRYLGLKQFDSFHILLIGFSQTLIIPSIILVVHYFYLSQNKDSLLQQISLLLIILMLPLSSLWAQTANNTHNINSSPSLSFISRHHSFDSSRSGGSNTIVSNGGSNGGGGGGNFPVSGIDAQLPPDIEKILHEDNNYKLLNSNNESVNDGDIIINDEGMITKQITIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1D8PUB6_CANAL</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">IAH1</name>
        <name evidence="3" type="ordered locus">CAALFM_CR10780CA</name>
        <name evidence="2" type="ordered locus">orf19.7667</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
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        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP017630">
        <property type="protein sequence ID" value="AOW31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_719426.1">
        <property type="nucleotide sequence ID" value="XM_714333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8PUB6"/>
    <dbReference type="SMR" id="A0A1D8PUB6"/>
    <dbReference type="FunCoup" id="A0A1D8PUB6">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="237561.A0A1D8PUB6"/>
    <dbReference type="GeneID" id="3638945"/>
    <dbReference type="KEGG" id="cal:CAALFM_CR10780CA"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CR_10780C_A"/>
    <dbReference type="eggNOG" id="KOG3035">
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        <property type="component" value="Chromosome R"/>
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        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
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        <property type="entry name" value="Iah1-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
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        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000201019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AOW31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="268" mass="30930" checksum="065E54BDD4DE24E9" modified="2017-01-18" version="1">MAWDKKKKKFSTIAIMEYGKFVLFGDSITQFSCTQYGFHPALQNVYIRKLDVINRGFSGYNSEHARQILPKILESETNIKLMTIFFGTNDAYDYINEIQTVELDRYKDNLSVMVQMVLDKNIKPIIIGPGLHDPKMAKAMLAERGRPIDKDPTTNQRLLKYSETAKKVAAQHNVAFIDTWNTLRQHQGWTKDQLFEVSATKDKWEIGESLAEIVSDGIHFTAKSYKILFEEIIRVIEEKYPELAPENLPSQLCDWKQINPNDLSSIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G1UAZ9</accession>
    <name>G1UAZ9_CANAL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAALFM_C703030WA</name>
        <name evidence="7" type="ordered locus">orf19.12625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP017629">
        <property type="protein sequence ID" value="AOW30649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_716980.1">
        <property type="nucleotide sequence ID" value="XM_711887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1UAZ9"/>
    <dbReference type="STRING" id="237561.G1UAZ9"/>
    <dbReference type="GeneID" id="3641380"/>
    <dbReference type="KEGG" id="cal:CAALFM_C703030WA"/>
    <dbReference type="CGD" id="CAL0000193692">
        <property type="gene designation" value="orf19.12625"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:C7_03030W_A"/>
    <dbReference type="eggNOG" id="ENOG502SVID">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_108996_0_0_1"/>
    <dbReference type="InParanoid" id="G1UAZ9"/>
    <dbReference type="OMA" id="TITIFHN"/>
    <dbReference type="OrthoDB" id="4044803at2759"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0000193692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW30649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000559"/>
        </source>
    </evidence>
    <sequence length="172" mass="19729" checksum="3C025F1C614F622A" modified="2011-10-19" version="1">MSLFRSLQNSPSTISIFHNSSIPLSNKLYDILEKAYDTQPEKPKHEFQIDLMKNKMPTYDQYKLIVDKYLKGSTSKTILHNCFPFLHDSKTELYNSKGNVVTVKGVEWANKTFSPAEYQMIYDTFNKLQESSDQSINTIASNVFQAPLVVDWDNDVIAGDEETLKAILSKYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>P0C8L0</accession>
    <name>CYB_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Complex III subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Complex III subunit III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Cytochrome b-c1 complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquinol-cytochrome-c reductase complex cytochrome b subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COB</name>
        <name type="synonym">CYTB</name>
        <name type="ordered locus">CM_00330W</name>
        <name type="ORF">CaalfMp11</name>
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    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    </organism>
    <geneLocation type="mitochondrion"/>
    <reference key="1">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="865" last="872">
            <title>Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.</title>
            <authorList>
                <person name="Anderson J.B."/>
                <person name="Wickens C."/>
                <person name="Khan M."/>
                <person name="Cowen L.E."/>
                <person name="Federspiel N."/>
                <person name="Jones T."/>
                <person name="Kohn L.M."/>
            </authorList>
            <dbReference type="PubMed" id="11208783"/>
            <dbReference type="DOI" id="10.1128/JB.183.3.865-872.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2023" name="Front. Cell. Infect. Microbiol." volume="13" first="1136698" last="1136698">
            <title>QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches.</title>
            <authorList>
                <person name="Zeng L."/>
                <person name="Huang Y."/>
                <person name="Tan J."/>
                <person name="Peng J."/>
                <person name="Hu N."/>
                <person name="Liu Q."/>
                <person name="Cao Y."/>
                <person name="Zhang Y."/>
                <person name="Chen J."/>
                <person name="Huang X."/>
            </authorList>
            <dbReference type="PubMed" id="36923588"/>
            <dbReference type="DOI" id="10.3389/fcimb.2023.1136698"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference evidence="9 10 11" key="3">
        <citation type="journal article" date="2022" name="Structure" volume="30" first="129" last="138.e4">
            <title>Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.</title>
            <authorList>
                <person name="Di Trani J.M."/>
                <person name="Liu Z."/>
                <person name="Whitesell L."/>
                <person name="Brzezinski P."/>
                <person name="Cowen L.E."/>
                <person name="Rubinstein J.L."/>
            </authorList>
            <dbReference type="PubMed" id="34525326"/>
            <dbReference type="DOI" id="10.1016/j.str.2021.08.006"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS) OF THE HOMODIMERIC RESPIRATORY COMPLEX III</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34525326, PubMed:36923588). The complex plays an important role in the uptake of multiple carbon sources present in different host niches (PubMed:36923588).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="2">Binds 2 heme b groups non-covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Leads to lethality, showing that it is an essential gene.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.</text>
    </comment>
    <dbReference type="EMBL" id="AF285261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="7RJA">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="K/T=1-387"/>
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    <dbReference type="PDB" id="7RJB">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="K=1-387"/>
    </dbReference>
    <dbReference type="PDB" id="7RJC">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="K=1-387"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
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    <dbReference type="PDBsum" id="7RJC"/>
    <dbReference type="PDBsum" id="7RJD"/>
    <dbReference type="PDBsum" id="7RJE"/>
    <dbReference type="AlphaFoldDB" id="P0C8L0"/>
    <dbReference type="EMDB" id="EMD-24482"/>
    <dbReference type="EMDB" id="EMD-24483"/>
    <dbReference type="EMDB" id="EMD-24484"/>
    <dbReference type="EMDB" id="EMD-24485"/>
    <dbReference type="EMDB" id="EMD-24486"/>
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        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="STRING" id="237561.P0C8L0"/>
    <dbReference type="ChEMBL" id="CHEMBL4296307"/>
    <dbReference type="EnsemblFungi" id="CM_00330W-T">
        <property type="protein sequence ID" value="CM_00330W-T-p1"/>
        <property type="gene ID" value="CM_00330W"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0000196083">
        <property type="gene designation" value="COB"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CM_00330W"/>
    <dbReference type="InParanoid" id="P0C8L0"/>
    <dbReference type="Proteomes" id="UP000000559">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00290">
        <property type="entry name" value="cytochrome_b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00284">
        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030689">
        <property type="entry name" value="Cytochrome_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048260">
        <property type="entry name" value="Cytochrome_b_C_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048259">
        <property type="entry name" value="Cytochrome_b_N_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038885">
        <property type="entry name" value="COB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3 5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3 4">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b562</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>b566</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="3"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="8"/>
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    </feature>
    <feature type="strand" evidence="13">
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            <begin position="21"/>
            <end position="23"/>
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        <location>
            <begin position="29"/>
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    <feature type="helix" evidence="12">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="turn" evidence="12">
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            <begin position="58"/>
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        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="61"/>
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        </location>
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        <location>
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            <end position="74"/>
        </location>
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        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="UniProtKB" id="P00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00968"/>
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    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="34525326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="34525326"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0007744" key="10">
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    </evidence>
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        <source>
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    <evidence type="ECO:0007829" key="12">
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7RJE"/>
        </source>
    </evidence>
    <sequence length="387" mass="43708" checksum="4F345A9AD99624F1" modified="2008-12-16" version="1">MPTRKSNTYLSLVNSYLIDSPQPSSINYWWNLGSLLGLCLVIQIASGVFLAMHYSSNIELAFDSVEHIMRDVNAGWLIRYIHANGASFFFICMYLHIGKALYYGSYKQPRVMLWVIGVVIFILTMAIAFMGYCLVYGQMSHWGATVITNLLSAIPFIGNDIVPFIWGGFSVSNPTIQRFFALHFLLPFILAALVCMHLMALHVHGSSNPVGITGNIDRLPMHPYFIFKDLITVFVFLLIFSLFVFYSPNTLGHPDNYIPGNPMVTPPSIVPEWYLLPFYAILRSIPDKLGGVIAMFGAILILLSLPYTDRSIIRGNSFKVLSKLAFYLFVFNFILLGNLGQLHVEVPYIQLGQFATAYYFAHYIIVVPVISTLENILYYIGTQTRVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-10-29" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q59LF3</accession>
    <accession>A0A1D8PQB3</accession>
    <name>RV167_CANAL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of cytoskeleton and endocytosis RVS167</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RVS167</name>
        <name type="ordered locus">CAALFM_C604040CA</name>
        <name type="ORF">CaO19.1220</name>
        <name type="ORF">CaO19.8807</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain SC5314 / ATCC MYA-2876)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="237561"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7329" last="7334">
            <title>The diploid genome sequence of Candida albicans.</title>
            <authorList>
                <person name="Jones T."/>
                <person name="Federspiel N.A."/>
                <person name="Chibana H."/>
                <person name="Dungan J."/>
                <person name="Kalman S."/>
                <person name="Magee B.B."/>
                <person name="Newport G."/>
                <person name="Thorstenson Y.R."/>
                <person name="Agabian N."/>
                <person name="Magee P.T."/>
                <person name="Davis R.W."/>
                <person name="Scherer S."/>
            </authorList>
            <dbReference type="PubMed" id="15123810"/>
            <dbReference type="DOI" id="10.1073/pnas.0401648101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Genome Biol." volume="8" first="RESEARCH52.1" last="RESEARCH52.12">
            <title>Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.</title>
            <authorList>
                <person name="van het Hoog M."/>
                <person name="Rast T.J."/>
                <person name="Martchenko M."/>
                <person name="Grindle S."/>
                <person name="Dignard D."/>
                <person name="Hogues H."/>
                <person name="Cuomo C."/>
                <person name="Berriman M."/>
                <person name="Scherer S."/>
                <person name="Magee B.B."/>
                <person name="Whiteway M."/>
                <person name="Chibana H."/>
                <person name="Nantel A."/>
                <person name="Magee P.T."/>
            </authorList>
            <dbReference type="PubMed" id="17419877"/>
            <dbReference type="DOI" id=".1186/gb-2007-8-4-r52"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Genome Biol." volume="14" first="RESEARCH97.1" last="RESEARCH97.14">
            <title>Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.</title>
            <authorList>
                <person name="Muzzey D."/>
                <person name="Schwartz K."/>
                <person name="Weissman J.S."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="24025428"/>
            <dbReference type="DOI" id=".1186/gb-2013-14-9-r97"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>SC5314 / ATCC MYA-2876</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="1272" last="1286">
            <title>Functional characterization of myosin I tail regions in Candida albicans.</title>
            <authorList>
                <person name="Oberholzer U."/>
                <person name="Iouk T.L."/>
                <person name="Thomas D.Y."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="15470256"/>
            <dbReference type="DOI" id="10.1128/EC.3.5.1272-1286.2004"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Infect. Immun." volume="77" first="4150" last="4160">
            <title>BAR domain proteins Rvs161 and Rvs167 contribute to Candida albicans endocytosis, morphogenesis, and virulence.</title>
            <authorList>
                <person name="Douglas L.M."/>
                <person name="Martin S.W."/>
                <person name="Konopka J.B."/>
            </authorList>
            <dbReference type="PubMed" id="19596778"/>
            <dbReference type="DOI" id="10.1128/IAI.00683-09"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="FEMS Yeast Res." volume="10" first="452" last="461">
            <title>Functional analysis of Candida albicans genes encoding SH3-domain-containing proteins.</title>
            <authorList>
                <person name="Reijnst P."/>
                <person name="Walther A."/>
                <person name="Wendland J."/>
            </authorList>
            <dbReference type="PubMed" id="20402797"/>
            <dbReference type="DOI" id="10.1111/j.1567-1364.2010.00624.x"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 6">Leads to defects in actin polarization, endocytosis, bud morphogenesis, as well as altered abundance and distribution of the cortical actin patches and increased sensitivity to calcofluor white and Congo red. Also shows attenuated virulence.</text>
    </comment>
    <dbReference type="EMBL" id="CP017628">
        <property type="protein sequence ID" value="AOW30325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_710570.2">
        <property type="nucleotide sequence ID" value="XM_705478.2"/>
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    <dbReference type="SMR" id="Q59LF3"/>
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        <property type="
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